TY - JOUR. T1 - Explaining the decline in coronary heart disease mortality rates in Japan. T2 - Contributions of changes in risk factors and evidence-based treatments between 1980 and 2012. AU - Ogata, Soshiro. AU - Nishimura, Kunihiro. AU - Guzman-Castillo, Maria. AU - Sumita, Yoko. AU - Nakai, Michikazu. AU - Nakao, Yoko M.. AU - Nishi, Nobuo. AU - Noguchi, Teruo. AU - Sekikawa, Akira. AU - Saito, Yoshihiko. AU - Watanabe, Taeko. AU - Kobayashi, Yasuki. AU - Okamura, Tomonori. AU - Ogawa, Hisao. AU - Yasuda, Satoshi. AU - Miyamoto, Yoshihiro. AU - Capewell, Simon. AU - OFlaherty, Martin. PY - 2019/9/15. Y1 - 2019/9/15. N2 - Background: We aimed to quantify contributions of changes in risks and uptake of evidence-based treatment to coronary heart disease (CHD) mortality trends in Japan between 1980 and 2012. Methods: We conducted a modelling study for the general population of Japan aged 35 to 84 years using the validated IMPACT model incorporating data sources like Vital Statistics. The main ...
TY - JOUR. T1 - Self-Reported Health and Outcomes in Patients With Stable Coronary Heart Disease. AU - Stewart, Ralph. AU - Hagstrom, Emil. AU - Held, Claes. AU - Wang, Tom. AU - Armstrong, Paul. AU - Aylward, Philip. AU - Cannon, Christopher. AU - Koenig, Wolfgang. AU - Lopez-Sendon, Jose. AU - Mohler III, Emile. AU - Hadziosmanovic, Nermin. AU - Krug-Gourley, Susan. AU - Ramos-Corrales, Marco. AU - Siddique, Saulat. AU - Steg, Philippe. AU - White, Harvey. AU - Wallentin, Lars. PY - 2017. Y1 - 2017. N2 - Background--The major determinants and prognostic importance of self-reported health in patients with stable coronary heart disease are uncertain. Methods and Results--The STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) trial randomized 15 828 patients with stable coronary heart disease to treatment with darapladib or placebo. At baseline, 98% of participants completed a questionnaire that included the question, Overall, how do you feel your general ...
TY - JOUR. T1 - Progression of coronary calcium and incident coronary heart disease events. T2 - MESA (Multi-Ethnic Study of Atherosclerosis). AU - Budoff, Matthew J.. AU - Young, Rebekah. AU - Lopez, Victor A.. AU - A. Kronmal, Richard. AU - Nasir, Khurram. AU - Blumenthal, Roger S.. AU - Detrano, Robert C.. AU - Bild, Diane E.. AU - Guerci, Alan D.. AU - Liu, Kiang. AU - Shea, Steven. AU - Szklo, Moyses. AU - Post, Wendy. AU - Lima, Joao. AU - Bertoni, Alain. AU - Wong, Nathan D.. PY - 2013/3/26. Y1 - 2013/3/26. N2 - Objectives: The study examined whether progression of coronary artery calcium (CAC) is a predictor of future coronary heart disease (CHD) events. Background: CAC predicts CHD events and serial measurement of CAC has been proposed to evaluate atherosclerosis progression. Methods: We studied 6,778 persons (52.8% female) aged 45 to 84 years from the MESA (Multi-Ethnic Study of Atherosclerosis) study. A total of 5,682 persons had baseline and follow-up CAC scans approximately 2.5 ± ...
Stressful Life Events and Coronary Heart Disease Patients, 978-613-8-23434-0, Psychological factors play a very important role in the existence and formation of Heart diseases, especially Coronary Heart Disease (CHD). Nowadays, heart diseases especially CHD which its clinical spectrum varies from silence ischemia to stable angina, unstable angina, myocardial infection and sudden heart death is one of the three main causes of death in the industrial countries besides cancer and brain stroke. Fifty million people die annually around the world; 12 million of them die because of cardiovascular diseases.Stress can affect persons health through behavioral and physiologic changes. Stress can also lead to heart diseases through psychological changes. It seems that stress has direct effects on coronary arteries and heart muscles. Nontraditional risk factors, such as psychological traits, have been increasingly recognized as important contributors to the genesis and outcomes of coronary artery disease. Mental
Indices of socio-economic deprivation are often used as a proxy for differences in the health behaviours of populations within small areas, but these indices are a measure of the economic environment rather than the health environment. Sets of synthetic estimates of the ward-level prevalence of low fruit and vegetable consumption, obesity, raised blood pressure, raised cholesterol and smoking were combined to develop an index of unhealthy lifestyle. Multi-level regression models showed that this index described about 50% of the large-scale geographic variation in CHD mortality rates in England, and substantially adds to the ability of an index of deprivation to explain geographic variations in CHD mortality rates.
The Stanford Five-City Project was initiated in 1978 to evaluate the effects of community-wide health education on coronary heart disease risk factors in two control San Luis Obispo and Modesto and two treatment Monterey and Salinas cities. This paper examines sex differences in the prevalence of smoking, hypercholesterolemia, and hypertension...
This multicenter, randomized, double-blind, placebo-controlled, parallel-group study will evaluate the potential of dalcetrapib to reduce cardiovascular morbidity and mortality in patients with stable coronary heart disease (CHD), with CHD risk equivalents or at elevated risk for cardiovascular disease. Eligible patients will be randomized to receive either dalcetrapib 600 mg orally daily or placebo orally daily, on a background of contemporary, guidelines-based medical care. Anticipated time on study treatment is 4 years ...
This multicenter, randomized, double-blind, placebo-controlled, parallel-group study will evaluate the potential of dalcetrapib to reduce cardiovascular morbidity and mortality in patients with stable coronary heart disease (CHD), with CHD risk equivalents or at elevated risk for cardiovascular disease. Eligible patients will be randomized to receive either dalcetrapib 600 mg orally daily or placebo orally daily, on a background of contemporary, guidelines-based medical care. Anticipated time on study treatment is 4 years ...
Abstract: Xin-Ke-Shu (XKS), a traditional Chinese medicine (TCM) preparation, has been widely used for treatment of coronary heart disease (CHD) in China. However, the active constituents of XKS and their interactions with targets remain unclear. In this study, we assessed two docking programs, LibDock and AutoDock, by calculating the root-mean-square deviation (RMSD) of X-ray structure reproduction and the enrichment factor (EF) in virtual screening; both proved to be practical in our protein-ligand complex systems. Moreover, the combined use of the two programs yielded better EFs for each target. We therefore used a combination of the two programs to investigate the interactions of the 51 chemical constituents identified from XKS with five CHD targets, namely peroxisome proliferator activated receptor γ (PPAR-γ), angiotensin-converting enzyme (ACE), hydroxymethylglutaryl coenzyme A receptor (HMGR), cyclooxygenase-2 (COX2), and thrombin. The docking results suggest that pueroside A, pueroside ...
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Coronary heart disease currently affects more than 7 million Americans, making it the most common form of heart disease. Men initially have a greater risk for developing coronary heart disease than women do. Once a woman reaches menopause however, her risk for heart disease eventually equals or surpasses that of a man. Experts believe this may be due in part to a decrease in the production of estrogen, a female sex hormone that appears to offer some protection against heart disease.. Coronary heart disease remains the number one cause of death for both women and men in the US, accounting for more than 500,000 deaths from heart attacks each year. Experts agree that many of these deaths can be prevented by changes in lifestyle, which when implemented, can directly reduce your chances for developing coronary heart disease.. Risk factors for coronary heart disease are circumstances or conditions that increase the likelihood of your developing this disease. Risk factors are generally divided into two ...
Heart disease is the number one killer in the United States (American Heart Association, 2005). The purpose of this study was to demonstrate the results of a twelve-week exercise program on coronary heart disease risk factors in full-time hospital employees. Methods: The participants were given cardiovascular, weight training, and flexibility recommendations to follow during a twelve-week period. The main heart disease risk factors measured before and after the completion of the exercise program were blood pressure, total cholesterol, HDL-cholesterol, and body mass index. The information was put into the Framingham Heart Score to estimate the participants 10-year risk of developing heart disease. Other factors measured to show the benefits of exercise included resting heart rate, weight, body fat percentage, waist and hip ratio, maximal oxygen uptake (VO2), and flexibility. Results: There were no significant results from any measurements taken.
BACKGROUND Adult height has been inversely associated with coronary heart disease risk in several studies. The mechanism for this association is not well understood, however, and this was investigated by examining components of stature, cardiovascular disease risk factors and subsequent coronary heart disease in a prospective study. METHODS All men aged 45-59 years living in the town of Caerphilly, South Wales were approached, and 2512 (89%) responded and underwent a detailed examination, which included measurement of height and sitting height (from which an estimate of leg length was derived). Participants were followed up through repeat examinations and the cumulative incidence of coronary heart disease-both fatal and non-fatal-over a 15 year follow up period is the end point in this report. RESULTS Cross sectional associations between cardiovascular risk factors and components of stature (total height, leg length and trunk length) demonstrated that factors related to the insulin resistance ...
Results:. Study 1: 10-year cardiovascular mortality was significantly and linearly associated with glycemic control (fasting blood glucose and glycated hemoglobin A1 levels) independently of the mode of treatment. A high fasting blood glucose level significantly predicted cardiovascular mortality in multiple logistic regression analysis independently of other risk factors. Study 2: Glycated hemoglobin A1c was the most important single risk factor associated with coronary heart disease death or all coronary heart disease events. In multiple logistic regression analysis, glycated hemoglobin A1c was significantly associated with coronary heart disease death after adjustment for other cardiovascular risk factors. ...
Higher magnesium intake was linked to a statistically significant risk reduction in fatal coronary heart disease and a risk reduction for sudden cardiac death among postmenopausal women, according to an analysis published in the Journal of Women’s Health.“Our understanding of the etiology and risk factors for fatal coronary heart disease and sudden cardiac death, particularly among
TY - JOUR. T1 - Ten-year predicted coronary heart disease risk in HIV-infected men and women. AU - Kaplan, Robert C.. AU - Kingsley, Lawrence A.. AU - Sharrett, A. Richey. AU - Li, Xiuhong. AU - Lazar, Jason. AU - Tien, Phyllis C.. AU - Mack, Wendy J.. AU - Cohen, Mardge H.. AU - Jacobson, Lisa. AU - Gange, Stephen J.. PY - 2007/10/22. Y1 - 2007/10/22. N2 - Background. Highly active antiretroviral therapy (HAART), in addition to traditional vascular risk factors, may affect coronary heart disease (CHD) risk in individuals with human immunodeficiency virus (HIV) infection. Methods. Among HIV-infected (931 men and 1455 women) and HIV-uninfected (1099 men and 576 women) adults, the predicted risk of CHD was estimated on the basis of age, sex, lipid and blood pressure levels, the presence of diabetes, and smoking status. Results. Among HIV-infected men, 2% had moderate predicted risk of CHD (10-year CHD risk, 15%-25%), and 17% had high predicted risk (10-year CHD risk of ≥25% or diabetes). Among ...
Of the 41 438 participants in the cohort, we excluded the following from the analyses: 193 for having coronary heart disease at baseline; 167 for an implausibly high or low dietary consumption, defined as 3 standard deviations either way from the cohort mean (,788 kcal/day or ,5710 kcal/day); and 321 for lacking data on important variables such as date of coronary heart disease event (n=12), smoking (n=22), diabetes mellitus (n=71), hypercholesterolaemia (n=197), and hypertension (n=60). Thus the analyses were carried out on 40 757 participants.. We used Cox regression to obtain hazard ratios for coronary heart disease according to sex specific quarters of fried food consumption. The quarter (first) with lowest consumption was used as reference. In the Cox models, age was the underlying time variable, with entry time defined as the participants age at recruitment and exit time as the age at the coronary heart disease event, death, or 31 December 2004, whichever came first. To reduce violations ...
Results. Both middle-aged and elderly men with T wave amplitudes ≥0.15 mV had a lower risk of myocardial infarction, coronary heart disease death and sudden death than men with T wave amplitudes 0.05 to 0.15 mV. The adjusted relative risk of coronary heart disease death was 0.5 (95% confidence interval [CI] 0.2 to 1.0); in men with T wave amplitude ≤0.05 mV, relative risk was 2.0 (95% CI 1.3 to 3.1). Slight ST segment elevation was also associated with decreased risk: relative risk 0.5 (95% CI 0.3 to 1.0) compared with the isoelectric ST segment level. In men with ST segment depression, relative risk was 2.2 (95% CI 1.4 to 3.4). The associations of T wave amplitude and ST segment level were independent of each other. ...
I dont know what to make of this new study. http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1001177 Background...
I dont like Mondays---day of the week of coronary heart disease deaths in Scotland: study of routinely collected data Academic Article ...
In a prospective study of over 17 000 civil servants followed up for 25 years, there was an inverse association between SES and CHD mortality in participants with and without prevalent CHD at baseline.. The inverse social gradient in CHD mortality could be a result of increased incidence (aetiology), case fatality (prognosis) or both among those of lower SES. Case fatality includes both survival of an acute event, such as myocardial infarction, and prognosis in chronic manifestations of CHD, such as angina. We studied the latter-established CHD in a working population- and found a significant effect of SES on CHD mortality among those with prevalent CHD defined by symptomatic status. When prevalent CHD was defined by Q, ST or T abnormality in the absence of symptoms, the SES effect was similar but the confidence intervals spanned unity. Participants with both symptoms and ECG abnormality were at very high risk (relative to those without symptoms or any ECG abnormality) and in this group there ...
TY - JOUR. T1 - Coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC) study. AU - Chambless, Lloyd E.. AU - Folsom, Aaron R.. AU - Sharrett, A. Richey. AU - Sorlie, Paul. AU - Couper, David. AU - Szklo, Moyses. AU - Nieto, F. Javier. PY - 2003/9/1. Y1 - 2003/9/1. N2 - Risk prediction functions for incident coronary heart disease (CHD) were estimated using data from the Atherosclerosis Risk in Communities (ARIC) Study, a prospective study of CHD in 15,792 persons recruited in 1987-1989 from four U.S. communities, with follow-up through 1998. Predictivity of which individuals had incident CHD was assessed by increase in area under ROC curves resulting from adding nontraditional risk factors and markers of subclinical disease to a basic model containing only traditional risk factors. We also assessed the increase in population attributable risk. The additional factors were body mass index; waist-hip ratio; sport activity index; forced expiratory volume; plasma ...
Doug Manuel, MD, MSc, William M. Flanagan, BM, Meltem Tuna, PhD, Anya Okhmatovskaia, PhD, Philippe Finès, PhD; Carol Bennett, MSc. Coronary heart disease risk factors in Canada: a Microsimulation predictive model. Simulated Technology for Applied Research (STAR). Slideshow 3725048 by cicero
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TY - JOUR. T1 - Value of genetic testing in the prevention of coronary heart disease events. AU - Hynninen, Yrjänä. AU - Linna, Miika. AU - Vilkkumaa, Eeva. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Background: The health economic evidence about the value and optimal targeting of genetic testing in the prevention of coronary heart disease (CHD) events has remained limited and ambiguous. The objective of this study is to optimize the population-level use and targeting of genetic testing alongside traditional risk factors in the prevention of CHD events and, thereby, to assess the cost-benefit of genetic testing. Methods and findings: We compare several strategies for using traditional and genetic testing in the prevention of CHD through statin therapy. The targeting of tests to different patient segments within these strategies is optimized by using a decision-analytic model, in which a patients estimated risk of CHD is updated based on test results using Bayesian methods. We adopt the perspective of ...
TY - JOUR. T1 - Consensus on. T2 - Screening and therapy of coronary heart disease in diabetic patients. AU - Rivellese, A. A.. AU - Piatti, P. M.. PY - 2011/10. Y1 - 2011/10. N2 - The screening and best treatment for coronary heart disease in diabetic patients is still a matter of debate. For this reason the main Italian scientific societies dealing with diabetes and cardiovascular diseases have tried to finalize a document providing shared recommendations based on the available evidence on: 1) how and who to screen for coronary heart disease, 2) methodologies for the characterization of existing coronary heart disease 3) evaluation of the optimal treatment of cardiovascular risk factors and 4) appropriate revascularization procedures. For each of these points, the levels of evidence and strength of recommendations used in the Italian Standard of Care were adopted.. AB - The screening and best treatment for coronary heart disease in diabetic patients is still a matter of debate. For this reason ...
TY - JOUR. T1 - Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke. T2 - A pooled analysis of 97 prospective cohorts with 1·8 million participants. AU - The Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (BMI Mediated Effects). AU - Lu, Yuan. AU - Hajifathalian, Kaveh. AU - Ezzati, Majid. AU - Woodward, Mark. AU - Rimm, Eric B.. AU - Danaei, Goodarz. AU - Selmer, Randi. AU - Strand, Bjorn H.. AU - Dobson, A.. AU - Hozawa, A.. AU - Nozaki, A.. AU - Okayama, Akira. AU - Rodgers, A.. AU - Tamakoshi, A.. AU - Zhou, B. F.. AU - Zhou, B.. AU - Yao, C. H.. AU - Jiang, C. Q.. AU - Gu, D. F.. AU - Heng, D.. AU - Giles, Graham G.. AU - Shan, G. L.. AU - Whitlock, G.. AU - Arima, H.. AU - Kim, H. C.. AU - Christensen, H.. AU - Horibe, H.. AU - Maegawa, H.. AU - Tanaka, H.. AU - Ueshima, Hirotsugu. AU - Zhang, H. Y.. AU - Kim, I. S.. AU - Suh, I.. AU - Fuh, J. L.. AU - Lee, J.. AU - Woo, Jean. AU - Xie, J. ...
Objectives. We attempted to determine whether elevated levels of the classic coronary heart disease risk factors are associated with increased coronary risk and all-cause mortality among elderly men with and without coronary heart disease at baseline. Methods. The classic coronary risk factor levels and risk of coronary events and total...
Since it is changing into a typical medical malady, it is necessary to concentrate on the risk factors for coronary heart disease. There are a variety of irregular conditions that have an effect on the guts and the vessels supplying the heart with blood. Coronary heart disease is the foremost widespread quite heart problem. Its additionally the foremost common reason for heart attacks.. Injury that occurs to the center when the supply of blood is reduced is known as coronary heart disease. What normally happens is, deposits that are fatty in nature, build up among the liner of blood vessels whose job its to supply blood to the guts muscles. This causes narrowing of the blood vessels and the ensuing issue could be a reduction within the blood provide to the heart muscles. This causes symptoms of pain called angina.. Causes of Coronary Heart Disease. There are risk factors for coronary heart disease that are thought of to be responsible for this disease. The most important and most well-known ...
BackgroundCurrent guidelines do not recommend routine cardiac stress testing in patients with stable coronary heart disease (CHD) unless they report symptoms of
TY - JOUR. T1 - More on coronary heart disease. T2 - The dietary sense and nonsense [3]. AU - Holmqvist, O. H.. AU - Bassler, T. J.. AU - Enig, M. G.. AU - Stone, N. J.. PY - 1994/1/1. Y1 - 1994/1/1. UR - http://www.scopus.com/inward/record.url?scp=1642500224&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=1642500224&partnerID=8YFLogxK. U2 - 10.1056/NEJM199409013310913. DO - 10.1056/NEJM199409013310913. M3 - Letter. C2 - 8047096. AN - SCOPUS:1642500224. VL - 331. SP - 614. EP - 616. JO - New England Journal of Medicine. JF - New England Journal of Medicine. SN - 0028-4793. IS - 9. ER - ...
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Flint, A.J., et al. (2010) Excess Weight and the Risk of Incident Coronary Heart Disease among Men and Women. Obesity (Silver Spring, Md.), 18, 377-383.
The Treating to New Targets (TNT) trial compared atorvastatin 80 mg (aiming at reducing LDL cholesterol | or = 75 mg/dl) and atorvastatin 10 mg (LDL | or = 100 mg/dl as target) in 10,001 patients with stable coronary heart disease followed up for 5 years. A reduction of major cardiovascular events of 22% was observed in the atorvastatin 80 mg group as compared to the atorvastatin 10 mg group (hazard ratio: 0.78; 95 % interval of confidence: 0.69-0.89; p | 0.001). Such clinical efficacy was obtained while a good drug safety profile was maintained. Total mortality was not significantly different between the two groups. However, and remarkably, cardiovascular death was not the first cause of death anymore in this atorvastatin-treated population. The results of TNT in patients with stable coronary heart disease thus confirm the results of PROVE-IT in patients with acute coronary syndrome. These two randomised controlled trials should encourage considering a LDL cholesterol level of 75 mg/dl (rather than
A high body mass index (BMI) is associated with an increased risk of mortality from coronary heart disease (CHD); however, a low BMI may also be associated with an increased mortality risk. There is limited information on the relation of incident CHD risk across a wide range of BMI, particularly in women. We examined the relation between BMI and incident CHD overall and across different risk factors of the disease in the Million Women Study. 1.2 million women (mean age = 56 years) participants without heart disease, stroke, or cancer (except non-melanoma skin cancer) at baseline (1996 to 2001) were followed prospectively for 9 years on average. Adjusted relative risks and 20-year cumulative incidence from age 55 to 74 years were calculated for CHD using Cox regression. After excluding the first 4 years of follow-up, we found that 32,465 women had a first coronary event (hospitalization or death) during follow-up. The adjusted relative risk for incident CHD per 5 kg/m2 increase in BMI was 1.23 (95%
Lifestyle and risk factor results clearly demonstrate a challenging gap between what is recommended in scientific guidelines and what is achieved in daily practice in high risk individuals in primary prevention of CVD.. Primary prevention of heart disease needs a comprehensive, multidisciplinary approach involving the high-risk population, their GPs and other health professionals, a health insurance system dedicated to prevention and all this complemented by a population strategy involving the community at large.. The European Society of Cardiology together with other partner Societies has engaged in a comprehensive programme of prevention of cardiovascular disease (CVD) since 1994. Guidelines on this important topic have been developed and updated at regular intervals over the last 13 years, most recently in 2007. The implementation of these guidelines is facilitated by the Joint European Prevention Committee and the new European Association for Cardiovascular Prevention and Rehabilitation ...
Coronary heart disease (CHD) is the leading cause of death in the United States. Previous research examining physicians ability to estimate cardiovascular risk has shown that physicians generally overestimate the absolute risk of CHD events. This question has, however, only studied risk prediction for a limited number of patient care scenarios. The aim of this study is to measure the ability of physicians to estimate the risk of CHD events in patients with no previous history of coronary heart disease. Twelve primary prevention scenarios with a 5-year risk of CHD events were developed. This questionnaire was surveyed at 3 university teaching hospitals where the participants were a convenience sample of internal medicine residents and fellows or attending physicians in general internal medicine or cardiology. For each scenario, physicians were asked to estimate the baseline 5-year risk of a coronary heart disease event and the revised risk if the patient were to receive lipid-lowering drug therapy.
Coronary heart disease (CHD) is the leading cause of death in the United States. Previous research examining physicians ability to estimate cardiovascular risk has shown that physicians generally overestimate the absolute risk of CHD events. This question has, however, only studied risk prediction for a limited number of patient care scenarios. The aim of this study is to measure the ability of physicians to estimate the risk of CHD events in patients with no previous history of coronary heart disease. Twelve primary prevention scenarios with a 5-year risk of CHD events were developed. This questionnaire was surveyed at 3 university teaching hospitals where the participants were a convenience sample of internal medicine residents and fellows or attending physicians in general internal medicine or cardiology. For each scenario, physicians were asked to estimate the baseline 5-year risk of a coronary heart disease event and the revised risk if the patient were to receive lipid-lowering drug therapy.
DALLAS, TX -The American Heart Association (AHA) and Verily, (formerly Google Life Sciences) announced today that AstraZeneca (AZ) has joined them in a bold new approach to find a cure for coronary heart disease and improve cardiovascular health. With a commitment of $75 million dollars over at least a five year period, the three organizations have initiated the single largest research project funding one leader and team in the fight to cure coronary heart disease. The application period for this new research enterprise officially opens today at 5:00 PM ET at: www.onebraveidea.com. The three organizations have joined forces to find one brave idea from a visionary leader. This person and their team will be awarded the opportunity and challenge to make a difference for the millions of people directly affected by coronary heart disease. Their goal: prevent or reverse coronary heart disease and its consequences, therein restoring cardiovascular health. Launched as One Brave Idea™, this research ...
Objective To assess the effect of using different risk calculation tools on how general practitioners and practice nurses evaluate the risk of coronary heart disease with clinical data routinely available in patients records. Design Subjective estimates of the risk of coronary heart disease and results of four different methods of calculation of risk were compared with each other and a reference standard that had been calculated with the Framingham equation; calculations were based on a sample of patients records, randomly selected from groups at risk of coronary heart disease. Setting General practices in central England. Participants 18 general practitioners and 18 practice nurses. Main outcome measures Agreement of results of risk estimation and risk calculation with reference calculation; agreement of general practitioners with practice nurses; sensitivity and specificity of the different methods of risk calculation to detect patients at high or low risk of coronary heart disease. Results Only a
The Effective Health Care Program of the AHRQ has released summary guides for clinicians and consumers that discuss adjunctive therapy options for patients with stable coronary heart disease.
Treating depression in those with coronary heart disease: CODIACS Vanguard Randomized Controlled Trial. NEW YORK - Depressive symptoms after heart disease are associated with a markedly increased risk of death or another heart attack. However, less has been known about whether treating heart attack survivors for depressive symptoms could relieve these symptoms, be cost-effective, and ultimately, reduce medical risk? Columbia University Medical Centers Karina W. Davidson, PhD and her research team now report a patient-centered approach that answers these questions in the affirmative.. With a grant from the National Institutes of Healths National Heart, Lung, and Blood Institute (NHLBI), Dr. Karina Davidson, director of the Center for Behavioral Cardiovascular Health at CUMC, and her team completed a randomized controlled trial with 150 patients with elevated depressive symptoms two to six months after hospitalization for heart disease. Patients were recruited from seven centers across the ...
TY - JOUR. T1 - Can non-medical factors contribute to disparities in coronary heart disease treatments?. AU - Barnhart, Janice M.. AU - Cohen, Oshra. AU - Wright, Natania. AU - Wylie-Rosett, Judith. PY - 2006/8/1. Y1 - 2006/8/1. N2 - Racial/ethnic and sex disparities in coronary heart disease treatment exist. We previously reported that physicians perceive non-clinical variables, such as a patients desire for a second opinion, as affecting revascularization decisions. The results of that study are further examined here, using factor analysis to identify significant interrelationships among the non-clinical variables, which could contribute to disparities in coronary revascularization (i.e., percutaneous transluminal coronary angioplasty [PTCA] or coronary artery bypass graft [CABG]). Five content themes emerged using factor analysis; these are related to the patients socioeconomic/lifestyle status, treatment preference, physician interaction, health-assertiveness, and aggressiveness. For the ...
Coronary heart disease (CHD) is when your coronary arteries become narrowed by a gradual build-up of fatty material within their walls called atherosclerosis. These arteries supply your heart muscle with oxygen-rich blood. The most common symptom of coronary heart disease (CHD) is chest pain.. You can also experience other symptoms, such as a light headed sensation, palpitations and shortness of breath. Some people may not have any symptoms before they are diagnosed.. Your arteries may become so narrow that they cannot deliver enough oxygen-rich blood to your heart. The pain and discomfort you may feel as a result is called angina.. If a piece of atheroma breaks off it may cause a blood clot to form. If it blocks your coronary artery and cuts off the supply of oxygen-rich blood to your heart muscle, your heart may become permanently damaged. This is known as a heart attack.. There are several ways you can help reduce your risk of developing coronary heart disease (CHD), such as lowering your ...
In the article by Williams et al, Is Optimal Medical Therapy Optimal Therapy for Multivessel Coronary Artery Disease?: Optimal Management of Multivessel Coronary Artery Disease, which appeared in the September 7, 2010 issue of the journal (Circulation 2010;122:943-945), there were two typographical errors:. On page 943, in the fourth paragraph Coronary Artery Surgical Study should read Coronary Artery Surgery Study.. In the same paragraph, European Coronary Surgical Study should read European Coronary Surgery Study.. The text has been corrected in the current online version of the manuscript. The authors regret the error.. ...
Baseline characteristics were compared between people with and without a family history of premature CHD. A Student t test was used for continuous variables (age, body mass index, waist circumference, waist/hip ratio, systolic and diastolic blood pressure, total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol) a χ2 test was used for categorical variables (sex, smoking status, diabetes mellitus). Because triglycerides and the FRS were not normally distributed, these parameters were log-transformed. The log-transformed variables were normally distributed and were compared using a Student t test.. The Framingham risk score was calculated using a previously reported algorithm, which takes into account age, sex, total cholesterol, HDL cholesterol, systolic and diastolic blood pressure, smoking and the presence of diabetes. Since the FRS overestimates CHD risk in Europeans, and more specifically in the EPIC-Norfolk study population, we recalibrated ...
In this analysis of the data from a longitudinal study on coronary heart disease risk factors, it was found that participants screened a few weeks after a major disaster (earthquake) had a higher heart rate, serum cholesterol levels, and serum triglyceride levels than matched participants that were screened shortly before the catastrophic event. The two groups of participants did not differ with regard to their characteristics at the baseline examination carried out 5 years previously. The lack of difference in blood pressure between exposed and nonexposed participants could be explained by the lag-time between the earthquake and the blood pressure measurements. We conclude that the acute stress associated with major disasters can influence risk factors for coronary heart disease. Permanent elevation of these risk factors due to the disruption of the social environment of the individuals affected by major disasters might be responsible for the apparent long-term adverse effects on cardiovascular ...
3 Department of Epidemiology, School of Public Health, Loma Linda University, Loma Linda, CA. Whole blood viscosity, plasma viscosity, hematocrit, and fibrinogen are considered independent risk factors for coronary heart disease and can be elevated by dehydration. The associations between fatal coronary heart disease and intake of water and fluids other than water were examined among the 8,280 male and 12,017 female participants aged 38-100 years who were without heart disease, stroke, or diabetes at baseline in 1976 in the Adventist Health Study, a prospective cohort study. A total of 246 fatal coronary heart disease events occurred during the 6-year follow-up. High daily intakes of water (five or more glasses) compared with low (two or fewer glasses) were associated with a relative risk in men of 0.46 (95% confidence interval (CI): 0.28, 0.75; p trend = 0.001) and, in women, of 0.59 (95% CI: 0.36, 0.97). A high versus low intake of fluids other than water was associated with a relative risk of ...
Title: Depression in Coronary Heart Disease Patients: Etiological and Screening Issues. VOLUME: 2 ISSUE: 2. Author(s):Colin R. Martin and David R. Thompson. Affiliation:Faculty of Medicine, TheNethersole School of Nursing, Chinese University of Hong Kong, EstherLee Building, Chung Chi College, Shatin, New Territories, Hong Kong,Peoples Republic of China.. Keywords:selective serotonin re-uptake inhibitor (SSRI), sertraline anti-depressant heart attack randomised, trial (SADHART), cardiac rehabilitation (CR), PHQ-2, CHD risk factor. Abstract: Coronary heart disease (CHD) is associated with significant psychiatric comorbidity, in particular, depression. Recent evidence suggests that depression following a coronary event or diagnosis is a significant risk factor for both mortality and morbidity. Further, there is compelling evidence that depression is a significant predictor in the development of CHD. Surprisingly, given the relationship of depression to patient outcome, screening for depressive ...
Effect of intensive lipid lowering with atorvastatin on cardiovascular outcomes in coronary heart disease patients with mild-to-moderate baseline elevations in alanine aminotransferase ...
TY - JOUR. T1 - Coronary heart disease mortality trends in Minnesota, 1960-80. T2 - The Minnesota heart survey. AU - Gillum, R. F.. AU - Hannan, P. J.. AU - Prineas, R. J.. AU - Jacobs, D. R.. AU - Gomez-Marin, O.. AU - Luepker, R. V.. AU - Baxter, J.. AU - Kottke, T. E.. AU - Blackburn, H.. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 1984. Y1 - 1984. N2 - Age-adjusted mortality rates and trends from coronary heart disease (CHD) in Minnesota for the years 1960 to 1980 differed among eight health service areas. Regression of ten socio-economic and demographic factors and intensive care and coronary care unit beds on area CHD mortality levels revealed a significant positive association only for levels of welfare income-maintenance assistance with CHD mortality levels; there were no associations with trends. Further studies are needed to explain variation within states of CHD mortality rate levels and trends.. AB - Age-adjusted mortality rates and trends from coronary ...
HealthDay News - Incident coronary heart disease (CHD) is associated with accelerated cognitive decline after, but not before, the event, according to a study published in the June 25 issue of the Journal of the American College of Cardiology.. Wuxiang Xie, PhD, from the Peking University Health Science Center in Beijing, and colleagues examined the cognitive trajectory before and after incident CHD diagnosis in a cohort of 7888 participants with no history of stroke or incident stroke during follow-up. Participants underwent a cognitive assessment at baseline in 2002 to 2003 and at least one other time point (from 2004-2005 to 2016-2017). Incident CHD was defined as a diagnosis of myocardial infarction and/or angina during follow-up.. The researchers observed a correlation for incident CHD with accelerated cognitive decline during a median follow-up of 12 years. The annual rate of cognitive decline was similar before CHD diagnosis for individuals who experienced incident CHD and for those who ...
TY - JOUR. T1 - Employment and recreation patterns in patients treated by percutaneous transluminal coronary angioplasty. T2 - A multicenter study. AU - Holmes, David. AU - Vlietstra, Ronald E.. AU - Mock, Michael B.. AU - Smith, Hugh C.. AU - Dorros, Gerald. AU - Cowley, Michael J.. AU - Kent, Kenneth M.. AU - Hammes, La Von N.. AU - Janke, Lynne. AU - Elveback, Lila R.. AU - Vetrovec, George W.. PY - 1983/10/1. Y1 - 1983/10/1. N2 - Employment and recreational patterns were analyzed in 279 patients who underwent percutaneous transluminal coronary angioplasty (PTCA) for treatment of symptomatic coronary artery disease. PTCA was successful in 180 patients (65%). When it was unsuccessful, coronary artery bypass graft surgery was usually performed (80%). Return-to-work rates were high irrespective of the outcome of PTCA. Of patients employed full-time or part-time before treatment, 98.5% of those who had successful PTCA alone and 97% of those whose PTCA was unsuccessful but who underwent ...
From Clinical Nutrition and Risk Factor Modification Center (D.J.A.J., C.W.C.K., A.M., E.V.), Department of Medicine, Division of Endocrinology and Metabolism (P.W.C.), and Department of Surgery, Division of Otolaryngology (W.Q., J.S.H.), St Michaels Hospital, Toronto, Ontario, Canada; Departments of Nutritional Sciences (D.J.A.J., C.W.C.K., A.M., T.L.P., D.F., E.V.), Biochemistry (P.W.C.), and Laboratory Medicine and Pathobiology (P.W.C.), Faculty of Medicine, University of Toronto, Toronto, Ontario; the Almond Board of California (K.G.L.), Modesto, Calif; and Health Research and Studies Center (G.A.S.), Los Altos, Calif. ...
Background The prevalence of coronary heart disease amongst South Asian population in the UK is higher compared to the general population. Objective This study sought to investigate beliefs and experiences of South Asian patients regarding coronary heart disease and medication taking behaviour. Setting A London Heart Attack Centre. Methods This mixed method study is part of an original pilot randomised study on 71 patients involving a pharmacy-led intervention to improve medication adherence in coronary heart disease patients. South Asian patients from the randomised study took part in qualitative semi-structured telephone interviews. Both South Asian and non-South Asian patients completed the questionnaire about adherence and beliefs regarding medicines using Morisky Scale and the Belief About Medicines Questionnaire-Specific at 2 weeks, 3 and 6 months. Outcome Patients beliefs about coronary heart disease and medication adherence. Results Seventeen South Asian patients and 54 non-South Asian ...
TY - JOUR. T1 - The role of public health versus invasive coronary interventions in the decline of coronary heart disease mortality. AU - Myocardial Infarction Data Acquisition System (MIDAS 39) Study Group. AU - Tuppo, Ehab E.. AU - Trivedi, Mihir P.. AU - Kostis, John B.. AU - Daevmer, Julian. AU - Cabrera, Javier. AU - Kostis, William J.. N1 - Funding Information: The authors would like to thank Dr. George Rhoads for his help in the research and data analysis and Dr. John Pantazopoulos for his help in the discussion. Publisher Copyright: © 2020 Elsevier Inc.. PY - 2021/3. Y1 - 2021/3. N2 - Purpose: There has been considerable debate on the extent to which the decline in coronary heart disease (CHD) mortality has been caused by better control of coronary risk factors in the general population or is the result of invasive coronary interventions in symptomatic individuals. Methods: Using the Myocardial Infarction Data Acquisition System, a statewide database of all cardiovascular hospital ...
Despite advances made in treating coronary heart disease (CHD), mortality due to CHD in Syria has been increasing for the past two decades. This study aims to assess CHD mortality trends in Syria between 1996 and 2006 and to investigate the main factors associated with them. The IMPACT model was used to analyze CHD mortality trends in Syria based on numbers of CHD patients, utilization of specific treatments, trends in major cardiovascular risk factors in apparently healthy persons and CHD patients. Data sources for the IMPACT model included official statistics, published and unpublished surveys, data from neighboring countries, expert opinions, and randomized trials and meta-analyses. Between 1996 and 2006, CHD mortality rate in Syria increased by 64%, which translates into 6370 excess CHD deaths in 2006 as compared to the number expected had the 1996 baseline rate held constant. Using the IMPACT model, it was estimated that increases in cardiovascular risk factors could explain approximately 5140 (81%
Coronary insufficiency | Percutaneous transluminal coronary angioplasty with stents placement. Cardiology: Treatment in Cologne, Germany ✈. Prices on BookingHealth.com - booking treatment online!
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This study examines the joint and separate influence of birth weight and body mass in young adulthood on subsequent coronary heart disease (CHD) risk. A cohort of 9,143 men born in Copenhagen, Denmark, in 1953, for whom information on birth weight and body weight and height around age 19 years were retrieved from birth certificates and conscript records, respectively, were followed from 1978 until 2005 (between age 25 and 52 years) for incident fatal and non-fatal CHD. Data on CHD were obtained through record linkage to the Cause of Death Registry and the National Patient Registry. During follow-up, a total of 475 men had a CHD diagnosis. Men with low birth weight, high body mass index (BMI) at age 19, a father from the working class, and low educational level at age 19 had an increased risk for CHD. Birth weight was inversely associated with CHD only in men with BMI of 25 kg/m(2) or above. Adjustment for childhood social circumstances and educational status at age 19 had minor influence on the ...
Motlagh B, ODonnell M, Yusuf S. Prevalence of cardiovascular risk factors in the Middle East: a systematic review. Eur J Cardiovasc Prev Rehabilm2009;16(3):268-80. Cole JH, Sperling LS. Premature coronary artery disease:clinical risk factors and prognosis. Curr Atheroscler Rep2004;6(2):121-5. Roest AM, Zuidersma M, de Jonge P. Myocardial infarction and generalized anxiety disorder: a 10-year follow-up. Br J Psychiatry 2012;200(4):324-9. Martens EJ, de Jonge P, Na B, et al. Scared to death? Generalized anxiety disorder and cardiovascular events in patients with stable coronary heart disease: The Heart and Soul Study. Arch Gen Psychiatry 2010;67(7):750-8. Huffman JC, Smith FA, Blais MA, et al. Anxiety, independent of depressive symptoms, is associated with in-hospital cardiac complications after acute myocardial infarction. J Psychosom Res 2008;65(6):557-63. Kawachi I, Sparrow D, Vokonas PS, et al. Symptoms of anxiety and risk of coronary heart disease. The NormativeAging Study. Circulation ...
TY - JOUR. T1 - Sleep duration, sleep quality and coronary heart disease mortality. AU - Strand, Linn B.. AU - Tsai, Min Kuang. AU - Gunnell, David. AU - Janszky, Imre. AU - Wen, Chi Pang. AU - Chang, Shu-Sen. PY - 2016/11/15. Y1 - 2016/11/15. KW - Sleep. KW - coronary heart disease. KW - cardiovascular disease. KW - sleep duration. KW - sleep quality. U2 - 10.1016/j.ijcard.2016.08.119. DO - 10.1016/j.ijcard.2016.08.119. M3 - Letter (Academic Journal). C2 - 27552574. VL - 223. SP - 534. EP - 535. JO - International Journal of Cardiology. JF - International Journal of Cardiology. SN - 0167-5273. ER - ...
The most abundant steroid in the human body, dehydroepiandrosterone (DHEA) is involved in the manufacture of testosterone, estrogen, progesterone, and corticosterone. Claes Ohlsson, from Sahlgrenska Academy (Sweden), and colleagues monitored 2,614 men, ages 69 to 80 years, who resided in 3 Swedish communities, for five years, during which DHEA levels were assessed. The findings demonstrated that the lower the DHEA level at the study start, the greater the risk of coronary heart disease events during the five-year follow-up. The study authors report that: Low serum levels of DHEA and its sulfate predict an increased risk of [coronary heart disease], but not [cerebrovascular disease], events in elderly men.. Asa Tivesten; Liesbeth Vandenput; Daniel Carlzon; Maria Nilsson; Magnus K. Karlsson; Claes Ohlsson; et al. Dehydroepiandrosterone and its Sulfate Predict the 5-Year Risk of Coronary Heart Disease Events in Elderly Men. J Am Coll Cardiol. 2014; 64(17):1801-1810.. ...
A comprehensive study in this weeks PLoS Medicine shows levels of the amino acid, homocysteine, have no meaningful effect on the risk of developing coronary heart disease, closing the door on the previously suggested benefits of lowering homocysteine with folate acid once and for all.. Previous studies have suggested that high blood levels of homocysteine might be a modifiable risk factor for coronary heart disease, but in a detailed analysis of data from 19 unpublished and 86 published studies, led by Robert Clarke from the Clinical Trial Service Unit and Epidemiological Studies Unit at the University of Oxford, the researchers found that lifelong moderate elevation of homocysteine levels had no significant effect on the risk of developing coronary heart disease. The study findings suggest that extensive publication bias, together with methodological problems, has played a role in previous suggestions linking homocysteine with coronary heart disease risk.. In their analysis, the authors found ...
TY - JOUR. T1 - A comparison of coronary heart disease event rates amoung urban Australian Aboriginal people and a matched non-Aboriginal population. AU - Bradshaw, Pamela. AU - Alfonso-Parada, Helman. AU - Finn, Judith. AU - Owen, Julie. AU - Thompson, Peter. PY - 2011. Y1 - 2011. U2 - 10.1136/jech.2009.098343. DO - 10.1136/jech.2009.098343. M3 - Article. VL - 65. SP - 315. EP - 319. JO - Journal of Epidemiology & Community Health. JF - Journal of Epidemiology & Community Health. SN - 0143-005X. ER - ...
PURPOSE: In this study we examined whether high glycemic index (GI) and glycemic load (GL) diets are associated with increased risk of developing coronary heart disease (CHD) in Whites and African Americans with and without type 2 diabetes.METHODS: Data on 13,051 patients ages 45 to 64 years from the Atherosclerosis Risk in Communities study were analyzed. The ARIC food frequency questionnaire baseline data provided GI and GL indices. A propensity score was created to estimate the effect of a patients covariates on energy-adjusted GI or GL. During a maximum of 17 years of follow-up, 1683 cases of CHD (371 with diabetes and 1312 without diabetes) were recorded.RESULTS: For every 5-units increase in GI, there was a 1.16-fold (95% confidence interval [95% CI], 1.01-1.33) increased risk of incident CHD in African Americans. For every 30-units increase in GL, there was a 1.11-fold (95% CI, 1.01-1.21) increased risk of incident CHD in Whites. High GL was an especially important CHD risk factor for ...
Design, setting and participants: A CVD risk-factor survey was carried out in rural south-eastern Australia from 2004 to 2006. Using a stratified random sample, data for 1116 participants aged 35-74 years were analysed. Applying the Framingham risk equations to risk-factor data, 5-year probabilities of a coronary heart disease event, stroke and cardiovascular event were calculated. The effect of different changes in risk factors were modelled to assess the extent to which cardiovascular diseases can be prevented by changing the risk factors at a population level (population strategy), among the high-risk individuals (high-risk strategy) or both ...
Using mortality data from National Institute of Statistics in Spain, we analyzed trends of infectious disease mortality rates in Spain during 1980-2011 to provide information on surveillance and control of infectious diseases. During the study period, 628,673 infectious disease-related deaths occurred, the annual change in the mortality rate was −1.6%, and the average infectious disease mortality rate was 48.5 deaths/100,000 population. Although the beginning of HIV/AIDS epidemic led to an increased mortality rate, a decreased rate was observed by the end of the twentieth century. By codes from the International Classification of Diseases, 9th revision, the most frequent underlying cause of death was pneumonia. Emergence and reemergence of infectious diseases continue to be public health problems despite reduced mortality rates produced by various interventions. Therefore, surveillance and control systems should be reinforced with a goal of providing reliable data for useful decision making.
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Objective To compare the application effect and cost in intracoronary stent implantation between domestic and imported drug eluting stent. Methods A total of 791 coronary heart disease patients undergoing intracoronary stent implantation were selected in a Grade 3 and first-class hospital in 2013,and they were divided into A group( using domestic drug eluting stent,n = 398) and B group( using imported drug eluting stent,n = 393) according to the types of stents. During the intracoronary stent implantation,patients of A group used Shanghai Minimally-invasive Firebird Ⅱ Drug-eluting Stents,while patients of B group received United States Medtronic Endenvor Drug Eluting Stents. Clinical data,operative success rate,locations of coronary artery lesions,number of implanted stents,clinical outcome,hospitalization related expenses and incidence of complications were compared between the two groups. Results Patients of the two groups completed the operation successfully,the operative success rates of the two
JA Allen, LA Throm; Percutaneous transluminal coronary angioplasty: a new alternative for ischemic heart disease. Crit Care Nurse 1 January 1982; 2 (1): 24-29. doi: https://doi.org/10.4037/ccn1982.2.1.24. Download citation file:. ...
Background This study sought to determine the relation between and discriminative capability of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) and coronary heart disease (CHD) in a large population of disease-free women.Methods Among participants of the Nurses Health Study who provided a blood sample, there were 421 cases of incident myocardial infarction during 14 years of follow-up. Controls were matched to cases 2:1 using risk set sampling based on age, smoking, and blood draw date.Results After conditioning on the matching factors, Lp-PLA(2) activity was significantly associated with myocardial infarction (relative risk [RR] 2.86 for extreme quartiles, 95% CI 1.98-4.12). Upon additional adjustment for lipid, inflammatory, and clinical risk factors, the RR remained statistically significant (RR 1.75, 95% CI 1.09-2.84). The discriminative capability of Lp-PLA(2) was assessed by comparing the area below the receiver operating characteristic curves for models with and without Lp-PLA(2) ...
Percutaneous transluminal coronary angioplasty (PTCA) is a minimally invasive procedure to open up blocked coronary arteries, allowing blood to circulate unobstructed to the heart muscle. Market Analysis and Insights: Global Percutaneous Translumi
Considerable epidemiological evidence has accumulated regarding the effect of postmenopausal estrogens on coronary heart disease risk. Five hospital-based case-control studies yielded inconsistent but generally null results; however, these are difficult to interpret due to the problems in selecting …
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The market for technologies and products in the treatment of coronary heart disease is forecast to grow from $12.2 billion in 2014 to $22.5 billion in 2021, according to a new study from Smithers.. Treatment of coronary artery disease by interventional cardiology, through angioplasty and stenting, remains competitive in its clinical outcomes and cost compared to traditional coronary artery bypass graft (CABG) and emerging minimally invasive alternatives to CABG. Further, manufacturers have largely eliminated the concerns about late stent thrombosis that caused a market slowdown in stents, as they have aggressively developed technology developments in stents, their composite materials, and coatings.. A new study from Smithers - The Future of Coronary Heart Disease Medical Devices to 2021 - shows the continued demand for these devices as clinically and cost-effective solutions to coronary artery disease. In the largest product area, coronary stents, despite an upwards of 90% penetration of ...
Background. The coronary risk in diabetes (CoRDia) trial (n = 211) compares the effectiveness of usual diabetes care with a self-management intervention (SMI), with and without personalised risk information (including genetics), on clinical and behavioural outcomes. Here we present an assessment of randomisation, the cardiac risk genotyping assay, and the genetic characteristics of the recruits.. Methods. Ten-year coronary heart disease (CHD) risk was calculated using the UKPDS score. Genetic CHD risk was determined by genotyping 19 single nucleotide polymorphisms (SNPs) using Randoxs Cardiac Risk Prediction Array and calculating a gene score (GS). Accuracy of the array was assessed by genotyping a subset of pre-genotyped samples (n = 185).. Results. Overall, 10-year CHD risk ranged from 2-72 % but did not differ between the randomisation groups (p = 0.13). The array results were 99.8 % concordant with the pre-determined genotypes. The GS did not differ between the Caucasian participants in the ...
In the present study of older community-dwelling individuals, Lp-PLA2 levels were significantly higher in those who developed CHD compared with those who did not. Associations between Lp-PLA2 and LDL, HDL, total cholesterol, and triglycerides were especially strong, and the magnitude of the correlations was in good agreement with previous studies (7,19). Despite these associations, Lp-PLA2 remained a strong and independent predictor of fatal and nonfatal CHD events, over and above these and other traditional risk factors. Thus, Lp-PLA2 added information to lipid and lipoprotein prediction of future CHD and may identify subpopulations at risk for CHD who would not be identified otherwise.. A similar independent association of Lp-PLA2 with CHD risk was reported in the younger participants from the WOSCOPS (5) and ARIC (7,19) studies and in a nested case-control study from the Rotterdam study (9). We now confirm these results for the first time in a cohort of apparently healthy older men and women ...
Finland has marked regional differences in the occurrence of coronary heart disease (CHD). Although the causes for these differences in CHD mortality and morbidity in the Finnish population are unknown, it offers an excellent opportunity to investigate the effects of non-insulin-dependent diabetes mellitus (NIDDM) on CHD risk in two populations differing significantly with respect to the occurrence of CHD. Therefore, we carried out a 7-year prospective population-based study including a large number of patients with NIDDM (East Finland: 253 men and 257 women; West Finland: 328 men, 221 women) and corresponding non-diabetic subjects (East Finland: 313 men, 336 women; West Finland: 325 men, 399 women). In both study populations the presence of NIDDM increased significantly the risk for CHD events (CHD mortality or all CHD events including CHD mortality or non-fatal myocardial infarction). Diabetic men had 3-4 fold higher and diabetic women 8-11-fold higher risk for CHD than corresponding non-diabetic
Subclinical heart disease has been reported to be an independent predictor of CAD risk in the general population. Women with subclinical disease were at greater risk for acute MI.47 Early investigation for CAD in the preclinical stage in young women with SLE is justified because cardiovascular events are an important cause of morbidity and mortality in this population. Published reports show that coronary disease (angina pectoris or acute MI) is more common in women with SLE than in the general population. Moreover, the mean age of patients with SLE who had coronary disease was younger than seen in the general population.4. We studied patients with more than five years of SLE, who had used steroids for at least one year, in attempt to evaluate patients at a greater risk for CAD.10-11,16,48 We analysed only asymptomatic patients, because we wanted to investigate subclinical heart disease. We also excluded patients older than 55 years, because women after this age have higher risk for CAD than ...
Coronary heart disease (CHD) is a disease in which a waxy substance called plaque builds up inside the coronary arteries. These arteries supply oxygen-rich blood to your heart muscle. You can read more information on this at the National Heart Lung and Blood Institute website.. We had this requirement come in from a partner on how we could store all the patient vital data within Dynamics 365 and calculate a risk score. Our example shows how to use North52s business rules engine for Dynamics 365 to set up a Multi-Sheet Decision Table to evaluate the patients risk score of Coronary Heart Disease.. Each Decision Table Sheet will evaluate specific Risk Factors with a variety of Conditions and decide if that risk factor applies to the patient. A final Decision Table Sheet will then provide a Risk Score based on the individual Risk Factors.. For this article it is assumed that you have at least basic familiarity with Decision Tables and/or have read the following articles:. ...
A cornerstone of conventional dietary advice is the recommendation to replace saturated fatty acids (SFA) with mostly n-6 polyunsaturated fatty acids (PUFA) to reduce the risk of coronary heart disease (CHD). Many clinical trials aimed to test this advice and have had their results pooled in several meta-analyses. However, earlier meta-analyses did not sufficiently account for major confounding variables that were present in some of those trials. Therefore, the aim of the study was to account for the major confounding variables in the diet heart trials, and emphasise the results from those trials that most accurately test the effect of replacing SFA with mostly n-6 PUFA.. Design Clinical trials were identified from earlier meta-analyses. Relevant trials were categorised as adequately controlled or inadequately controlled depending on whether there were substantial dietary or non-dietary differences between the experimental and control groups that were not related to SFA or mostly n-6 PUFA ...
Coronary heart disease (CHD) is the most common cause of death and disability in the United Kingdom. It causes around 94,000 deaths in the UK each year and around one in five men and one in seven women will die from the disease.. Coronary heart disease is usually caused by atherosclerosis, where fatty deposits (atheroma) develop in the walls of the arteries. Atherosclerosis causes symptoms when it partially or completely blocks the arteries that supply the heart muscle with blood. This manifests as a number of conditions including stable angina (where atheroma restricts blood flow) and acute coronary syndromes (where clot formation occurs on the atheroma and causes an abrupt narrowing or complete blockage of the artery). These are described in the relevant sections.. There are two ways to improve blood flow to heart muscle when the arteries become blocked. Percutaneous Coronary Intervention (PCI) and surgical coronary artery bypass grafting (CABG).. PCI is performed under local anaesthetic. A ...