Background: Coronary artery disease is sometimes associated with chronic conduction block. Our aim is to correlate between chronic conduction block and coronary artery disease. We performed ECG and coronary angiography of all patients who were admitted for permanent pacemaker implantation to find correlation between them. Methods: Coronary angiography was performed in all 160 patients of chronic conduction block during twenty four months of study period who were admitted for pacemaker implantation. We compared the coronary artery disease in different types of conduction block. Results: Among the study population 35(22%) patients are of single vessel coronary artery disease (CAD),13 (8%) patients had double vessel coronary artery disease, 6 (4%) patients had triple vessel coronary artery disease, 2 (1%) patients had left main disease and 104 (65%) patients had normal or insignificant coronary anatomy. Conclusion: Coronary artery disease is quite common in chronic conduction disorder. So there ...
Table of Contents. Table of Contents 2. List of Tables 8. List of Figures 9. Introduction 10. Global Markets Direct Report Coverage 10. Coronary Artery Disease (CAD) (Ischemic Heart Disease) Overview 11. Therapeutics Development 12. Pipeline Products for Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Overview 12. Pipeline Products for Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Comparative Analysis 13. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Therapeutics under Development by Companies 14. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Therapeutics under Investigation by Universities/Institutes 17. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Pipeline Products Glance 18. Late Stage Products 18. Clinical Stage Products 19. Early Stage Products 20. Unknown Stage Products 21. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Products under Development by Companies 22. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Products under ...
Vasc Health Risk Manag. 2014 Jan 21;10:55-62. doi: 10.2147/VHRM.S53557. eCollection 2014.. Roed T1, Kristoffersen US2, Knudsen A3, Wiinberg N4, Lebech AM1, Almdal T5, Thomsen RW6, Kjær A2, Weis N7.. Abstract. OBJECTIVE: Chronic hepatitis C is a global health problem and has been associated with coronary artery disease. Our aim was to examine the prevalence of coronary artery disease risk markers including endothelial biomarkers in patients with chronic hepatitis C and matched comparisons without manifest cardiovascular disease or diabetes in a cross-sectional design.. METHODS: Sixty patients with chronic hepatitis C (mean age 51 years) were recruited from the Department of Infectious Diseases at Copenhagen University Hospital, and compared with 60 age-matched non-hepatitis C virus-infected individuals from a general population survey. We examined traditional coronary artery disease risk factors, metabolic syndrome, carotid intima media thickness, and a range of endothelial biomarkers.. RESULTS: ...
Objectives: Higher coronary atherosclerotic burden has been associated with increased cardiovascular events including mortality. The SYNTAX score (SXs) reflects coronary atherosclerotic burden. Given the body of evidence implicating inflammation in atherosclerotic process, we hypothesized that procalcitonin (PCT) as an inflammatory marker may be related to coronary atherosclerotic burden. Thus, we aimed to investigate the relationship between serum PCT levels and SXs in patients with stable CAD. ...
TY - JOUR. T1 - Long-Term Prognosis of Vasospastic Angina without Significant Atherosclerotic Coronary Artery Disease. AU - Egashira, Kcnsuke. AU - Kikuchi, Yutaka. AU - Sagara, Tomohiko. AU - Sugihara, Masayoshi. AU - Nakamura, Motoomi. PY - 1987/1/1. Y1 - 1987/1/1. N2 - Long-term prognosis of 90 patients with vasospastic angina without significant coronary artery disease (less than 50% reduction in luminal diameter) was examined for a mean follow-up period of 4 years. All patients had episodes of angina at rest and were treated with calcium antagonists. One patient developed myocardial infarction and 2 died suddenly during the follow-up period. In the patient with myocardial infarction, there was an abrupt worsening of angina prior to the infarction despite therapy with a calcium antagonist. One of the sudden death patients discontinued his calcium antagonist before his death. Of the sudden death patients, one had ventricular tachycardia and the other had a complete atrioventricular block ...
BACKGROUND: Patients with obstructive left main coronary artery disease are usually treated with coronary-artery bypass grafting (CABG). Randomized trials have suggested that drug-eluting stents may be an acceptable alternative to CABG in selected patients with left main coronary disease. METHODS: We randomly assigned 1905 eligible patients with left main coronary artery disease of low or intermediate anatomical complexity to undergo either percutaneous coronary intervention (PCI) with fluoropolymer-based cobalt-chromium everolimus-eluting stents (PCI group, 948 patients) or CABG (CABG group, 957 patients). Anatomic complexity was assessed at the sites and defined by a Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score of 32 or lower (the SYNTAX score reflects a comprehensive angiographic assessment of the coronary vasculature, with 0 as the lowest score and higher scores [no upper limit] indicating more complex coronary anatomy). The primary end point was
TY - JOUR. T1 - Metabolic syndrome and angiographic coronary artery disease prevalence in association with the framingham risk score. AU - Konstantinou, Dimitris M.. AU - Chatzizisis, Yiannis S.. AU - Louridas, George E.. AU - Giannoglou, George D.. PY - 2010/6/1. Y1 - 2010/6/1. N2 - Background: The association of metabolic syndrome with coronary artery disease (CAD) has been studied extensively. However, little is known about the effect of Framingham risk score (FRS) and metabolic syndrome components on the association of metabolic syndrome with angiographically significant CAD. Our aim was to investigate whether that relationship is influenced by individuals 10-year CAD risk profile as assessed by FRS. Furthermore, we sought to elucidate whether metabolic syndrome is associated with angiographically significant CAD independently of its individual components. Methods: We studied a consecutive sample of 150 patients undergoing coronary angiography for the evaluation of chest pain. Metabolic ...
OBJECTIVES: This study sought to ascertain the relationship of 9p21 locus with: 1) angiographic coronary artery disease (CAD) burden; and 2) myocardial infarction (MI) in individuals with underlying CAD. BACKGROUND: Chromosome 9p21 variants have been robustly associated with coronary heart disease, but questions remain on the mechanism of risk, specifically whether the locus contributes to coronary atheroma burden or plaque instability. METHODS: We established a collaboration of 21 studies consisting of 33,673 subjects with information on both CAD (clinical or angiographic) and MI status along with 9p21 genotype. Tabular data are provided for each cohort on the presence and burden of angiographic CAD, MI cases with underlying CAD, and the diabetic status of all subjects. RESULTS: We first confirmed an association between 9p21 and CAD with angiographically defined cases and control subjects (pooled odds ratio [OR]: 1.31, 95% confidence interval [CI]: 1.20 to 1.43). Among subjects with angiographic CAD (n
TY - JOUR. T1 - Internal pudendal artery stenoses and erectile dysfunction. T2 - Correlation with angiographic coronary artery disease. AU - Rogers, Jason H. AU - Karimi, Houshang. AU - Kao, John. AU - Link, Daniel P. AU - Javidan, Javid. AU - Yamasaki, Dwayne S.. AU - Dolan, Mark. AU - Laird, John R.. AU - Low, Reginald. PY - 2010/11/15. Y1 - 2010/11/15. N2 - Objectives: To describe the angiographic characteristics of pelvic arterial disease in patients with erectile dysfunction (ED) nonresponsive to phosphodiesterase-5 inhibitors (PDE5i) and suspected coronary artery disease (CAD). Background: ED and CAD share common risk factors which can result in endothelial dysfunction, atherosclerosis and flow-limiting stenoses in the coronary and internal pudendal arteries. Methods: Ten patients undergoing cardiac catheterization with ED and a history of unsatisfactory response to a PDE5i were studied. ED severity was quantified using the International Index of ED scoring system. We performed angiography ...
Thesis, English, Role of monocyte chemotactic protein 1|(mcp1)in diagnosis of patients with atherosclerotic coronary artery disease for Ebraheem Dalia El Morsy
Archbold Hosts Health Talk on Coronary Artery Disease Wednesday, February 11, 2015 Coronary artery disease, also known as coronary heart disease...
Paraoxonase-1 (PON1) is an antioxidant enzyme, that resides on high-density lipoprotein (HDL). PON1-activity, is heavily influenced by the PON1-Q192R polymorphism. PON1 is considered to protect against atherosclerosis, but it is unclear whether this relation is independent of its carrier, HDL. In order to evaluate the atheroprotective potential of PON1, we assessed the relationships among PON1-genotype, PON1-activity and risk of future coronary artery disease (CAD), in a large prospective case-control study. Methodology/Principal Findings: Cases (n = 1138) were apparently healthy men and women aged 45-79 years who developed fatal or nonfatal CAD during a mean follow-up of 6 years. Controls (n = 2237) were matched by age, sex and enrollment time. PON1-activity was similar in cases and controls (60.7 +/- 645.3 versus 62.6 +/- 645.8 U/L, p = 0.3) and correlated with HDL-cholesterol levels (r = 0.16, p , 0.0001). The PON1-Q192R polymorphism had a profound impact on PON1-activity, but did not predict ...
TY - JOUR. T1 - Algorithm to predict triple-vessel/left main coronary artery disease in patients without myocardial infarction. T2 - An international cross validation. AU - Detrano, Robert. AU - Jánosi, A.. AU - Steinbrunn, Walter. AU - Pfisterer, Matthias. AU - Schmid, Johann Jakob. AU - Maggie Meyer, M.. AU - Guppy, Kern H.. AU - Abi-Mansour, Pierre. PY - 1991. Y1 - 1991. N2 - Logistic regression was applied to the clinical, risk factor, and exercise data of consecutive angiographic referrals without prior myocardial infarction to determine an algorithm predicting the probability of triple-vessel/left main coronary artery disease. These data were obtained from a total of 1,074 such subjects from patient populations at four centers (Cleveland Clinic Foundation, Cleveland, Ohio; Hungarian Institute of Cardiology, Budapest, Hungary; the university hospitals, Zurich and Basel, Switzerland; and the Veterans Administration Medical Center, Long Beach, Calif.) and used to derive four separate ...
... Rev Cardiovasc Med. 2011;12(2):e77-83. Authors: Lee MS, Nguyen J. Coronary artery bypass grafting (CABG) is the gold standard for the treatment of left main disease, whereas percutaneous coronary intervention is a viable option for patients who are candidates for revascularization but ineligible for CABG. CABG is limited by extended hospital stay followed by rehabilitation and mediocre long-term patency of saphenous vein grafts. Drug-eluting stents decrease the restenosis rates compared with bare metal stents and provide comparable clinical outcomes with those of CABG. Patients with isolated left main disease limited to the ostium or midbody are most likely to have good clinical outcomes with low restenosis and stent thrombosis rates. The results of the ongoing EXCEL trial, which compares left main percutaneous coronary intervention with drug-eluting stents and CABG, will provide insight regarding the ideal revascularization ...
Association of epicardial fat, hypertension, subclinical coronary artery disease, and metabolic syndrome with left ventricular diastolic dysfunction
TY - JOUR. T1 - ACR appropriateness criteria chronic chest pain - Low to intermediate probability of coronary artery disease. AU - Woodard, Pamela K.. AU - White, Richard D.. AU - Abbara, Suhny. AU - Araoz, Philip A.. AU - Cury, Ricardo C.. AU - Dorbala, Sharmila. AU - Earls, James P.. AU - Hoffmann, Udo. AU - Hsu, Joe Y.. AU - Jacobs, Jill E.. AU - Javidan-Nejad, Cylen. AU - Krishnamurthy, Rajesh. AU - Mammen, Leena. AU - Martin, Edward T.. AU - Ryan, Thomas. AU - Shah, Amar B.. AU - Steiner, Robert M.. AU - Vogel-Claussen, Jens. AU - White, Charles S.. PY - 2013. Y1 - 2013. N2 - Chronic chest pain can arise from a variety of etiologies. However, of those potential causes, the most life-threatening include cardiac disease. Chronic cardiac chest pain may be caused either by ischemia or atherosclerotic coronary artery disease or by other cardiac-related etiologies, such as pericardial disease. To consider in patients, especially those who are at low risk for coronary artery disease, are ...
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Abstract:. Background: Type 2 diabetes mellitus is often associated with severe Coronary artery disease (CAD). Since patients with higher risk of severe disease are likely to get better benefit from aggressive management, it is essential to identify factors which are associated with severe macrovascular disease. We looked at the possibility of hyperinsulinemia being a marker for severe and complex coronary artery disease in type 2 diabetes mellitus, to select patients who would benefit from aggressive treatment. Methods: A cross sectional study of 290 type 2 diabetic patients, who underwent coronary angiogram for the evaluation of clinically suspected CAD at a tertiary care hospital were recruited. Biochemical and anthropometric parameters were analysed. Insulin resistance was measured by homeostasis model assessment method. Angiographically measured syntax score of more than 22 is considered to be severe and complex CAD. Receiver operating curve characteristic was performed to find out the ...
Abstract:. Background: Non-communicable diseases constitute about 68% of global death annually. Among NCD deaths, cardiovascular diseases (CVD) ranks first with a share of 46.2% amounting to 17.5 million deaths. First degree relatives of patients with coronary heart disease have a higher risk of getting cardiovascular events due to interplay between genetic as well as environmental factors. The aim of this research WAS to assess the prevalence of Cardiovascular Disease (CVD) risk factors and to estimate the cardiovascular risk among first degree relatives of CAD patients. Methodology: A cross-sectional study was performed in first degree relatives of coronary artery disease patients in cardiology ward of JIPMER a tertiary care hospital in Puducherry. Overall 218 first degree relatives aged ≥18 were involved in study. The desired information was obtained using a pre-tested questionnaire and participants were also subjected to anthropometric measurements and laboratory investigations. WHO/ISH ...
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Background. Diverse ethnic groups may differ regarding the risk factors and severity of coronary artery disease (CAD). This study sought to assess the association between ethnicity and CAD risk and severity in six major Iranian ethnic groups.. Methods. In this study, 20,165 documented coronary artery disease patients who underwent coronary angiography at a tertiary referral heart center were recruited. The demographic, laboratory, clinical, and risk factor data of all the patients were retrieved. The Gensini score (an indicator of CAD severity) was calculated for all, and the risk factors and severity of CAD were compared between the ethnical groups, using adjusted standardized residuals, Kruskal-Wallis test, and multivariable regression analysis.. Results. The mean age of the participants (14,131 [70.1%] men and 6034 [29.9%] women) was 60.7 ± 10.8 years. The Fars (8.7%) and Gilak (8.6%) ethnic groups had the highest prevalence of ≥4 simultaneous risk factors. The mean Gensini score was the ...
Coronary arteries supply oxygen-rich blood to the heart muscle. Coronary artery disease results from atherosclerosis, a buildup of fatty deposits and plaque in the lining of a coronary artery, which narrows the artery and causes a decrease in blood flow to the heart muscle.. When a coronary artery suddenly becomes blocked and blood flow to an area of heart muscle stops, it is called a heart attack. A heart attack can permanently damage heart muscle and cause the affected area of the heart not to pump properly.. Common symptoms of coronary artery disease include shortness of breath and angina (pain or a feeling of increased pressure in the chest). Less common symptoms include nausea, sweating, fatigue, dizziness and decreased exercise tolerance.. In addition to diet, exercise, medication therapy and coronary artery bypass graft (CABG) surgery there are a number of minimally invasive procedures that can restore blood flow through a blocked coronary artery. These procedures include:. ...
Ling Jun Chen, Mercer University College of Pharmacy Coronary artery disease leads to the narrowing of coronary arteries and is associated with risk factors that include cigarette smoking, hypertension, hyperlipidemia, and diabetes. [1] European and U.S. guidelines have declared that patients with coronary artery disease have an increased risk of developing ischemia and infarction. Coronary-artery…
Polymorphisms in paraoxonase 1 (PON1) coding for PON1 enzyme have been studied as genetic markers of coronary artery disease (CAD). PON1 Q192R and PON1 L55M polymorphisms have been analyzed extensively, but data on association and role of these polymorphisms in the etiology of CAD are conflicting. In this study, we tested the genetic association between PON1 Q192R and PON1 L55M polymorphisms and CAD among north Indians. MATERIALS AND METHODS: Two hundred eighty-five angiographically proven patients with coronary artery disease and 200 sex-matched and ethnically matched controls were genotyped for 2 PON1 polymorphisms by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Genotype/ allele frequencies were compared in patients and controls using the chi-square test. RESULTS: At PON1-192 locus, there were significant differences between patients and controls (P, 0.05), leading to significant odds ratios for RR genotype (OR= 1.92, CI: 1.19-3.10) and *R allele ...
TY - JOUR. T1 - Usefulness of myocardial perfusion echocardiography to identify obstructive coronary artery disease in patients with abnormal ventricular septal motion. AU - Spevack, Daniel M.. AU - Shoyeb, Abu. AU - Yoon, Andrew J.. AU - Gordon, Garet M.. AU - Matros, Todd. AU - Reynolds, Harmony A.. AU - Shah, Alan. AU - Tunick, Paul A.. AU - Kronzon, Itzhak. PY - 2005/4/1. Y1 - 2005/4/1. N2 - Twenty-three patients who had septal wall motion abnormalities and who underwent angiography within 2 weeks were evaluated by myocardial perfusion echocardiography. Mean perfusion score (plateau video intensity times the wash-in rate) was lower in segments that were supplied by obstructed coronary arteries in real time (7.5 vs 22.6 dB/s, p ,0.005) and with end-systolic triggering (8.6 vs 20.9 dB/s, p ,0.001). Lower mean septal perfusion scores (,12 dB/s) were seen in 14 of 16 patients who had obstructive septal coronary artery disease, and normal mean septal perfusion scores were seen in 6 of 7 patients ...
Insulin-resistance is associated with cardiovascular disease but it is not used as a marker for disease in clinical practice. To study the association between the homeostatic model assessment (HOMA-IR) and triglyceride/HDLc ratio (TG/HDLc) with the presence of coronary artery disease in patients submitted to cardiac catheterization. In a cross-sectional study, 131 patients (57.0 ± 10 years-old, 51.5% men) underwent clinical, laboratory and angiographic evaluation and were classified as No CAD (absence of coronary artery disease) or CAD (stenosis of more than 30% in at least one major coronary artery). Prevalence of coronary artery disease was 56.7%. HOMA-IR and TG/HDLc index were higher in the CAD vs No CAD group, respectively: HOMA-IR: 3.19 (1.70-5.62) vs. 2.33 (1.44-4.06), p = 0.015 and TG/HDLc: 3.20 (2.38-5.59) vs. 2.80 (1.98-4.59) p = 0.045) - median (p25-75). After a ROC curve analysis, cut-off values were selected based on the best positive predictive value for each variable: HOMA-IR = 6.0, TG
Insulin-resistance is associated with cardiovascular disease but it is not used as a marker for disease in clinical practice. To study the association between the homeostatic model assessment (HOMA-IR) and triglyceride/HDLc ratio (TG/HDLc) with the presence of coronary artery disease in patients submitted to cardiac catheterization. In a cross-sectional study, 131 patients (57.0 ± 10 years-old, 51.5% men) underwent clinical, laboratory and angiographic evaluation and were classified as No CAD (absence of coronary artery disease) or CAD (stenosis of more than 30% in at least one major coronary artery). Prevalence of coronary artery disease was 56.7%. HOMA-IR and TG/HDLc index were higher in the CAD vs No CAD group, respectively: HOMA-IR: 3.19 (1.70-5.62) vs. 2.33 (1.44-4.06), p = 0.015 and TG/HDLc: 3.20 (2.38-5.59) vs. 2.80 (1.98-4.59) p = 0.045) - median (p25-75). After a ROC curve analysis, cut-off values were selected based on the best positive predictive value for each variable: HOMA-IR = 6.0, TG
Coronary calcium score is an independent predictor of risk of significant coronary artery disease. It may refine overall risk of coronary artery disease estimated with conventional risk factors. It is based on CT examination and calculation of the Agatston score from the images.
Medical Management Of Stable Coronary Artery Disease ,Stable Coronary Artery Disease (Management patients with stable known or suspected
In this 2-center study of 2,583 consecutive patients without prior known CAD and without obstructive CAD, nonobstructive coronary artery plaque presence and extent as identified by 64-detector row CCTA are associated with heightened mortality risk in a 3-year follow-up period. The CCTA nonobstructive plaque assessment added significant risk prediction beyond patient demographic data, traditional CAD risk factors, and Framingham risk score.. The results of the present study suggest a potential utility for diagnosis of nonobstructive CAD by CCTA. Such patients experience heightened mortality risk, even though they represent a patient population for whom functional stress testing would be expected to be negative and who might not be referred for evaluation by invasive coronary angiography (ICA) after CCTA. Our results confirm prior observations of a high negative predictive value of a normal CCTA for later adverse clinical events but are additive to the prior published reports by identifying a ...
The use of non-invasive imaging to identify ruptured or high-risk coronary atherosclerotic plaques would represent a major clinical advance for prevention and treatment of coronary artery disease. We used combined PET and CT to identify ruptured and
Change in R wave amplitude (mean delta R) was measured sequentially during and after 12 lead maximal treadmill exercise tests in 14 subjects with normal coronary arteries and 62 patients with coronary artery disease. In normal subjects mean delta R decreased maximally one minute after exercise and returned to control levels within three minutes. In contrast, mean delta R increased in patients with coronary artery disease, the greatest change occurring in patients with either triple vessel or left main disease or those with an akinetic region on the left ventriculogram. R wave amplitude returned to resting levels in five minutes. Increase in R wave amplitude was not directly related to changes in the ST segment. Changes in R wave amplitude during maximal treadmill exercise may improve the discrimination between patients with and without coronary artery disease and may help to identify those patients with abnormal left ventricular function. ...
BACKGROUND: Coronary artery disease is a major cause of morbidity and mortality worldwide, and is a consequence of acute thrombotic events involving activation of platelets and coagulation proteins. Factor Xa inhibitors and aspirin each reduce thrombotic events but have not yet been tested in combination or against each other in patients with stable coronary artery disease. METHODS: In this multicentre, double-blind, randomised, placebo-controlled, outpatient trial, patients with stable coronary artery disease or peripheral artery disease were recruited at 602 hospitals, clinics, or community centres in 33 countries. This paper reports on patients with coronary artery disease. Eligible patients with coronary artery disease had to have had a myocardial infarction in the past 20 years, multi-vessel coronary artery disease, history of stable or unstable angina, previous multi-vessel percutaneous coronary intervention, or previous multi-vessel coronary artery bypass graft surgery. After a 30-day run ...
TY - JOUR. T1 - Dietary supplementation and engaging in physical activity as predictors of coronary artery disease among middle-aged women. AU - Tsai, Ching Ching. AU - Hsieh, Ming Hsiung. AU - Li, Ai Hsien. AU - Chen, Ping Ling. AU - Jeng, Chii. PY - 2013/9. Y1 - 2013/9. N2 - Aim and objectives: To explore risk factors for coronary artery disease (CAD) among middle-aged women in Taiwan. Background: Coronary artery disease is a leading cause of death among females. Risk factors for CAD vary due to differences in ethnicity, gender and age. However, few studies have documented risk factors among middle-aged women. Design: We employed a cross-sectional, comparative study design. Methods: Sixty-five middle-aged women who were suspected of having CAD and who received cardiac catheterisation were purposively sampled and divided into a CAD group (with at least one coronary artery with , 50% stenosis) and a control group, according to the results of catheterisation. Individual questionnaires regarding ...
Percutaneous coronary intervention (PCI) is the most commonly performed treatment for coronary atherosclerosis. It is associated with a higher incidence of repeat revascularization procedures compared to coronary artery bypass grafting surgery. Recent results indicate that PCI is only cost-effective for a subset of patients. Estimating risks of treatment options would be an effort toward personalized treatment strategy for coronary atherosclerosis. In this paper, we propose to model clinical knowledge about the treatment of coronary atherosclerosis to identify patient-subgroup-specific classifiers to predict the risk of adverse events of different treatment options. We constructed one model for each patient subgroup to account for subgroup-specific interpretation and availability of features and hierarchically aggregated these models to cover the entire data. In addition, we deviated from the current clinical workflow only for patients with high probability of benefiting from an alternative treatment,
Coronary artery disease and heart failure are both highly prevalent diseases with a global prevalence of 93 million and 40 million. These patients are at increased risk of morbidity and mortality. The management of these patients involves medical therapy, and both diseases can be treated using the heart rate-lowering drug ivabradine. However, the evidence regarding the use of ivabradine in the treatment of coronary artery disease and/or heart failure is unclear. Our objective is to assess the beneficial and harmful effects of ivabradine in the treatment of coronary artery disease and/or heart failure. This protocol for a systematic review was undertaken using the recommendations of The Cochrane Collaboration, the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA-P), and the eight-step assessment procedure suggested by Jakobsen and colleagues. We plan to include all relevant randomised clinical trials assessing the use of ivabradine in the treatment of coronary artery
Previous studies have shown that traditional risk factors such as hypercholesterolemia and hypertension account for only a small proportion of the dramatically increased risk of atherosclerotic coronary artery disease (CAD) in systemic lupus erythematosus (SLE). However, in these studies, exposure to risk factors was measured only at baseline. In this study, our objective was to compare measures of cumulative exposure with remote and recent values for each of total cholesterol (TC), systolic (SBP), and diastolic (DBP) blood pressure in terms of ability to quantify risk of atherosclerotic CAD in patients with SLE. Patients in the Toronto lupus cohort had TC and BP measured at each clinic visit and were followed up prospectively for the occurrence of CAD. For each patient, arithmetic mean, time-adjusted mean (AM) and area-under-the-curve (AUC) were calculated for serial TC, SBP, and DBP measurements. Proportional hazards regression models were used to compare these summary measures with recent and first
Methods and Results-To examine any association between rosiglitazone use and cardiovascular events among patients with diabetes mellitus and coronary artery disease, we analyzed events among 2368 patients with type 2 diabetes mellitus and coronary artery disease in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial. Total mortality, composite death, myocardial infarction, and stroke, and the individual incidence of death, myocardial infarction, stroke, congestive heart failure, and fractures, were compared during 4.5 years of follow-up among patients treated with rosiglitazone versus patients not receiving a thiazolidinedione by use of Cox proportional hazards and Kaplan-Meier analyses that included propensity matching. After multivariable adjustment, among patients treated with rosiglitazone, mortality was similar (hazard ratio [HR], 0.83; 95% confidence interval [CI], 0.58-1.18), whereas there was a lower incidence of composite death, myocardial infarction, and ...
In this paper, 37 patients (23 males-14 females) undergoing aortocoronary bypass surgery and 20 cases (10 males-10 females) as a control group, were studied for their total plasma cholesterol, triglyceride, high density lipoprotein (HDL), low density lipoprotein (LDL), apolipoprotein A1(Apo A1) and apolipoprotein B (Apo B) levels. The predictive value of these levels in coronary artery disease were assessed angiographically and peroperatively in the number of stennosed wessels, extent of atherosclerosis (coronary score) and internal diameters of the bypassed coronary arteries.. In both sexes, no correlation was found between coronary artery disease and the levels of triglycerides and LDL.. Cholesterol and Apo 1 levels in men, were significantly lower than that of control group, Also, the levels of Apo 1 and the internal diameter of the bypassed coronary arteries, were correlated in men.. There was a significant correlation between the levels of Apo 1 and B, and the extent of coronary artery ...
Although atherosclerosis is a systemic disease, plaque progression and complications occur in a focal, patchy pattern. It remains challenging to predict which segments of a given coronary artery will show accelerated progression of atherosclerosis.. Coronary endothelial dysfunction, characterized by a segmental vasoconstrictive response to the endothelium-dependent vasodilator acetylcholine, is considered the earliest stage of atherosclerosis in patients with angiographically nonobstructive coronary arteries. Therefore, sites with endothelial dysfunction may signal future progression of segmental coronary atherosclerosis (1). Using serial intravascular ultrasound (IVUS) imaging, we tested the hypothesis that coronary segments with endothelial dysfunction are associated with plaque progression in patients with nonobstructive coronary artery disease.. In this prospective study, 22 patients underwent coronary angiography with coronary endothelial function assessment and IVUS for clinical purposes ...
The coronary arteries are the main blood vessels that supply the heart with blood, nutrients and oxygen. When they become damaged or diseased, usually due to a buildup of plaque, the result is coronary arterial disease. This buildup can narrow your coronary arteries over time, causing the heart to receive less blood and can eventually lead to causing chest pain (angina), shortness of breath or other uncomfortable symptoms.. A complete blockage, caused either by accumulated plaques or a ruptured plaque, can result in heart attack (an injury to the heart muscle that results from a loss of blood supply). Since coronary arterial disease can often take decades to develop, it can go virtually unnoticed until it produces a heart attack.. Uncontrolled risk factors ...
Left main coronary artery (LMCA) disease has been reported in up to 10% of all patients with coronary artery disease (CAD) and in the majority of cases are associated with severe three-vessel CAD. Among patients with chronic coronary syndrome revascularization of significant LMCA disease improves prognosis, while there is a debate about which revascularization strategy, CABG surgery or percutaneous coronary interventions to use. We do a review of the available evidence about the impact of LMCA lesions on patient prognosis according to CAD extension and clinical presentation, the outcome after percutaneous or surgical revascularization, the procedural challenges of LMCA PCI and the available armamentarium to optimally treat this relevant population.. ...
BACKGROUND AND PURPOSE: Ischemic stroke (IS) and coronary artery disease (CAD) share several risk factors and each has a substantial heritability. We conducted a genome-wide analysis to evaluate the extent of shared genetic determination of the two diseases. METHODS: Genome-wide association data were obtained from the METASTROKE, Coronary Artery Disease Genome-wide Replication and Meta-analysis (CARDIoGRAM), and Coronary Artery Disease (C4D) Genetics consortia. We first analyzed common variants reaching a nominal threshold of significance (P|0.01) for CAD for their association with IS and vice versa. We then examined specific overlap across phenotypes for variants that reached a high threshold of significance. Finally, we conducted a joint meta-analysis on the combined phenotype of IS or CAD. Corresponding analyses were performed restricted to the 2167 individuals with the ischemic large artery stroke (LAS) subtype. RESULTS: Common variants associated with CAD at P|0.01 were associated with a
Inflammation plays an important role in coronary artery disease from the initiation of endothelial dysfunction to plaque formation to final rupture of the plaque. In this study, we investigated the potential pathophysiological and clinical relevance of novel cytokines secreted from various cells including adipocytes, endothelial cells, and inflammatory cells, in predicting coronary artery disease (CAD) in asymptomatic subjects with type 2 diabetes mellitus. We enrolled a total of 70 asymptomatic type 2 diabetic patients without a documented history of cardiovascular disease, and determined serum levels of chemerin, omentin-1, YKL-40, and sCD26. We performed coronary computed tomographic angiography (cCTA) in all subjects, and defined coronary artery stenosis ≥ 50 % as significant CAD in this study. Subjects were classified into two groups: patients with suspected coronary artery stenosis on cCTA (group I, n = 41) and patients without any evidence of stenosis on cCTA (group II, n = 29). Group I showed
TY - JOUR. T1 - Radiation-induced coronary artery disease in Hodgkins disease. AU - Miltényi, Zsófia. AU - Keresztes, Katalin. AU - Garai, Ildikó. AU - Édes, István. AU - Galajda, Zoltán. AU - Tóth, László. AU - Illés, Árpád. PY - 2004/1/1. Y1 - 2004/1/1. N2 - Purpose Secondary malignant tumours and cardiovascular complications are of great importance among the late complications after treatment for Hodgkins disease (HD) because they may significantly reduce the patients life expectancy. We report on coronary artery disease (CAD) after treatment for HD. Methods and Materials We present the case of two female patients with HD who received mediastinal irradiation after which complete remission was achieved. In 12 and 19 years after the onset of the disease, control examinations revealed ischaemic heart disease, which was confirmed by coronary arteriography and solved by stent implantation in one of the patients and bypass surgery in the other one. Conclusions Ischaemic heart disease ...
In this issue of iJACC, Silverman et al. (1) report the relationship of baseline Agatston coronary artery calcium (CAC) score and coronary calcium distribution with future incident coronary revascularization in 6,540 MESA (Multi-Ethnic Study of Atherosclerosis) participants. The primary findings of this novel analysis is that baseline calcium score and the number of vessels with CAC were each independently predictive of future coronary revascularizations over a median follow-up of 8.5 years. Additionally, among subjects who underwent revascularization, those with more diffuse baseline CAC were at higher risk to undergo coronary artery bypass graft (CABG) versus percutaneous coronary intervention (PCI). Specifically, adjusted for overall CAC score, individuals with 3- and 4-vessel CAC were 3 to 4 times more likely to undergo coronary revascularization than were patients with CAC in a single vessel, and ≥3 vessel CAC was strongly predictive of the risk for future CABG, particularly when ...
TY - JOUR. T1 - Myocardium perfusion scintigraphy in evaluation of endovascular treatment results of coronary artery disease. AU - Lishmanov, Yu B.. AU - Vesoina, J. V.. AU - Rybalchenko, E. V.. AU - Krylov, A. L.. PY - 2004. Y1 - 2004. N2 - Purpose: To determine abilities and principal features of prospective scintigraphic evaluation of endovascular treatment results of coronary artery disease (CAD) using thallium-199 perfusion single-photon emission computed tomography. Material and methods: Forty CAD patients were investigated by perfusion scintigraphy before and 2-3 weeks, 3-6 months and 1-2 years after coronary artery stenting. The character and size of perfusion defects and presence of the reverse radionuclide redistribution phenomenon were estimated. Results: The coronary stenting almost results to the 80 % decrease of mean size of transitory ischemic zones. The presence of reversible perfusion defects after operation was bound up with the incomplete revascularization or with X-syndrome. ...
In patients with left main coronary artery disease and low or intermediate SYNTAX scores by site assessment, PCI with everolimus-eluting stents was noninferior to CABG with respect to the rate of the composite end point of death, stroke, or myocardial infarction at 3 years. (Funded by Abbott Vascula …
The subject has any condition which could interfere with or for which the treatment might interfere with the conduct of the study, or which would, in the opinion of the Investigator increase the risk of the subjects participation in the study. This would include, but is not limited to alcoholism, drug dependency or abuse, psychiatric disease, epilepsy or any unexplained blackouts, previous hypersensitivity to drugs, and severe asthma ...
The subject has any condition which could interfere with or for which the treatment might interfere with the conduct of the study, or which would, in the opinion of the Investigator increase the risk of the subjects participation in the study. This would include, but is not limited to alcoholism, drug dependency or abuse, psychiatric disease, epilepsy or any unexplained blackouts, previous hypersensitivity to drugs, and severe asthma ...