Background: Coronary artery disease is sometimes associated with chronic conduction block. Our aim is to correlate between chronic conduction block and coronary artery disease. We performed ECG and coronary angiography of all patients who were admitted for permanent pacemaker implantation to find correlation between them. Methods: Coronary angiography was performed in all 160 patients of chronic conduction block during twenty four months of study period who were admitted for pacemaker implantation. We compared the coronary artery disease in different types of conduction block. Results: Among the study population 35(22%) patients are of single vessel coronary artery disease (CAD),13 (8%) patients had double vessel coronary artery disease, 6 (4%) patients had triple vessel coronary artery disease, 2 (1%) patients had left main disease and 104 (65%) patients had normal or insignificant coronary anatomy. Conclusion: Coronary artery disease is quite common in chronic conduction disorder. So there ...

Table of Contents. Table of Contents 2. List of Tables 8. List of Figures 9. Introduction 10. Global Markets Direct Report Coverage 10. Coronary Artery Disease (CAD) (Ischemic Heart Disease) Overview 11. Therapeutics Development 12. Pipeline Products for Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Overview 12. Pipeline Products for Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Comparative Analysis 13. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Therapeutics under Development by Companies 14. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Therapeutics under Investigation by Universities/Institutes 17. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Pipeline Products Glance 18. Late Stage Products 18. Clinical Stage Products 19. Early Stage Products 20. Unknown Stage Products 21. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Products under Development by Companies 22. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Products under ...

Vasc Health Risk Manag. 2014 Jan 21;10:55-62. doi: 10.2147/VHRM.S53557. eCollection 2014.. Roed T1, Kristoffersen US2, Knudsen A3, Wiinberg N4, Lebech AM1, Almdal T5, Thomsen RW6, Kjær A2, Weis N7.. Abstract. OBJECTIVE: Chronic hepatitis C is a global health problem and has been associated with coronary artery disease. Our aim was to examine the prevalence of coronary artery disease risk markers including endothelial biomarkers in patients with chronic hepatitis C and matched comparisons without manifest cardiovascular disease or diabetes in a cross-sectional design.. METHODS: Sixty patients with chronic hepatitis C (mean age 51 years) were recruited from the Department of Infectious Diseases at Copenhagen University Hospital, and compared with 60 age-matched non-hepatitis C virus-infected individuals from a general population survey. We examined traditional coronary artery disease risk factors, metabolic syndrome, carotid intima media thickness, and a range of endothelial biomarkers.. RESULTS: ...

Objectives: Higher coronary atherosclerotic burden has been associated with increased cardiovascular events including mortality. The SYNTAX score (SXs) reflects coronary atherosclerotic burden. Given the body of evidence implicating inflammation in atherosclerotic process, we hypothesized that procalcitonin (PCT) as an inflammatory marker may be related to coronary atherosclerotic burden. Thus, we aimed to investigate the relationship between serum PCT levels and SXs in patients with stable CAD. ...

TY - JOUR. T1 - Long-Term Prognosis of Vasospastic Angina without Significant Atherosclerotic Coronary Artery Disease. AU - Egashira, Kcnsuke. AU - Kikuchi, Yutaka. AU - Sagara, Tomohiko. AU - Sugihara, Masayoshi. AU - Nakamura, Motoomi. PY - 1987/1/1. Y1 - 1987/1/1. N2 - Long-term prognosis of 90 patients with vasospastic angina without significant coronary artery disease (less than 50% reduction in luminal diameter) was examined for a mean follow-up period of 4 years. All patients had episodes of angina at rest and were treated with calcium antagonists. One patient developed myocardial infarction and 2 died suddenly during the follow-up period. In the patient with myocardial infarction, there was an abrupt worsening of angina prior to the infarction despite therapy with a calcium antagonist. One of the sudden death patients discontinued his calcium antagonist before his death. Of the sudden death patients, one had ventricular tachycardia and the other had a complete atrioventricular block ...

Coronary artery disease is a condition in which the coronary arteries are narrowed by deposits called plaques.. The coronary arteries originate from the aorta and supply blood and oxygen to your heart muscle allowing it pump blood to the body. Normal coronary arteries allow blood to flow freely. However, these arteries can become narrowed by inflammatory fatty deposits called plaques. This disease process is called atherosclerosis. Atherosclerosis that occurs in the coronary arteries is called coronary artery disease.. These plaques build up over time and can decrease the amount of oxygen reaching your heart. Mild coronary artery disease may develop over decades without any symptoms. More severe coronary artery disease can cause chest pain, called angina, and shortness of breath.. If a plaque suddenly ruptures, a blood clot can form and block the hearts blood supply. This is called a heart attack and it can cause permanent damage to the heart. Over time, severe coronary artery disease can also ...

BACKGROUND: Patients with obstructive left main coronary artery disease are usually treated with coronary-artery bypass grafting (CABG). Randomized trials have suggested that drug-eluting stents may be an acceptable alternative to CABG in selected patients with left main coronary disease. METHODS: We randomly assigned 1905 eligible patients with left main coronary artery disease of low or intermediate anatomical complexity to undergo either percutaneous coronary intervention (PCI) with fluoropolymer-based cobalt-chromium everolimus-eluting stents (PCI group, 948 patients) or CABG (CABG group, 957 patients). Anatomic complexity was assessed at the sites and defined by a Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score of 32 or lower (the SYNTAX score reflects a comprehensive angiographic assessment of the coronary vasculature, with 0 as the lowest score and higher scores [no upper limit] indicating more complex coronary anatomy). The primary end point was

TY - JOUR. T1 - Metabolic syndrome and angiographic coronary artery disease prevalence in association with the framingham risk score. AU - Konstantinou, Dimitris M.. AU - Chatzizisis, Yiannis S.. AU - Louridas, George E.. AU - Giannoglou, George D.. PY - 2010/6/1. Y1 - 2010/6/1. N2 - Background: The association of metabolic syndrome with coronary artery disease (CAD) has been studied extensively. However, little is known about the effect of Framingham risk score (FRS) and metabolic syndrome components on the association of metabolic syndrome with angiographically significant CAD. Our aim was to investigate whether that relationship is influenced by individuals 10-year CAD risk profile as assessed by FRS. Furthermore, we sought to elucidate whether metabolic syndrome is associated with angiographically significant CAD independently of its individual components. Methods: We studied a consecutive sample of 150 patients undergoing coronary angiography for the evaluation of chest pain. Metabolic ...

Coronary artery disease is among the most common causes of disability and death. Often, by the time symptoms occur, the process may already be far advanced. Frequently,t he first symptom of coronary artery disease is heart attack and sudden death. Dangerous coronary artery disease may be present in individuals that are totally asymptomatic. A recent study showed that a family history of early-onset coronary artery disease (CAD) is associated with significant amounts of plaque in the coronary arteries apparently healthy patients.. Researchers demonstrated a significant amount of plaque present (coronary plaque burden) in apparently healthy middle-aged close relatives of individuals with early-onset of coronary artery disease. This study underscores the fact that asymptomatic patients may benefit from early cardiac screening and that is especially true for individuals with a family history of early-onset CAD may benefit from screening for subclinical atherosclerosis.. The Cardiac portion of the ...

OBJECTIVES: This study sought to ascertain the relationship of 9p21 locus with: 1) angiographic coronary artery disease (CAD) burden; and 2) myocardial infarction (MI) in individuals with underlying CAD. BACKGROUND: Chromosome 9p21 variants have been robustly associated with coronary heart disease, but questions remain on the mechanism of risk, specifically whether the locus contributes to coronary atheroma burden or plaque instability. METHODS: We established a collaboration of 21 studies consisting of 33,673 subjects with information on both CAD (clinical or angiographic) and MI status along with 9p21 genotype. Tabular data are provided for each cohort on the presence and burden of angiographic CAD, MI cases with underlying CAD, and the diabetic status of all subjects. RESULTS: We first confirmed an association between 9p21 and CAD with angiographically defined cases and control subjects (pooled odds ratio [OR]: 1.31, 95% confidence interval [CI]: 1.20 to 1.43). Among subjects with angiographic CAD (n

TY - JOUR. T1 - Internal pudendal artery stenoses and erectile dysfunction. T2 - Correlation with angiographic coronary artery disease. AU - Rogers, Jason H. AU - Karimi, Houshang. AU - Kao, John. AU - Link, Daniel P. AU - Javidan, Javid. AU - Yamasaki, Dwayne S.. AU - Dolan, Mark. AU - Laird, John R.. AU - Low, Reginald. PY - 2010/11/15. Y1 - 2010/11/15. N2 - Objectives: To describe the angiographic characteristics of pelvic arterial disease in patients with erectile dysfunction (ED) nonresponsive to phosphodiesterase-5 inhibitors (PDE5i) and suspected coronary artery disease (CAD). Background: ED and CAD share common risk factors which can result in endothelial dysfunction, atherosclerosis and flow-limiting stenoses in the coronary and internal pudendal arteries. Methods: Ten patients undergoing cardiac catheterization with ED and a history of unsatisfactory response to a PDE5i were studied. ED severity was quantified using the International Index of ED scoring system. We performed angiography ...

Coronary Artery Disease welcomes reports of original research with a clinical emphasis, including observational studies, clinical trials, translational research, novel imaging, pharmacology and interventional approaches as well as advances in laboratory research that contribute to the understanding of coronary artery disease. Each issue of Coronary Artery Disease is divided into four areas of focus: Original Research articles, Review in Depth articles by leading experts in the field, Editorials and Images in Coronary Artery Disease. The Editorials will comment on selected original research published in each issue of Coronary Artery Disease, as well as highlight controversies in coronary artery disease understanding and management.

Thesis, English, Role of monocyte chemotactic protein 1|(mcp1)in diagnosis of patients with atherosclerotic coronary artery disease for Ebraheem Dalia El Morsy

Archbold Hosts Health Talk on Coronary Artery Disease Wednesday, February 11, 2015 Coronary artery disease, also known as coronary heart disease...

Paraoxonase-1 (PON1) is an antioxidant enzyme, that resides on high-density lipoprotein (HDL). PON1-activity, is heavily influenced by the PON1-Q192R polymorphism. PON1 is considered to protect against atherosclerosis, but it is unclear whether this relation is independent of its carrier, HDL. In order to evaluate the atheroprotective potential of PON1, we assessed the relationships among PON1-genotype, PON1-activity and risk of future coronary artery disease (CAD), in a large prospective case-control study. Methodology/Principal Findings: Cases (n = 1138) were apparently healthy men and women aged 45-79 years who developed fatal or nonfatal CAD during a mean follow-up of 6 years. Controls (n = 2237) were matched by age, sex and enrollment time. PON1-activity was similar in cases and controls (60.7 +/- 645.3 versus 62.6 +/- 645.8 U/L, p = 0.3) and correlated with HDL-cholesterol levels (r = 0.16, p , 0.0001). The PON1-Q192R polymorphism had a profound impact on PON1-activity, but did not predict ...

The Coronary Artery Disease Treatment Devices market is expected to grow from USD X.X million in 2020 to USD X.X million by 2026, at a CAGR of X.X% during the forecast period. The global Coronary Artery Disease Treatment Devices market report is a comprehensive research that focuses on the overall consumption structure, development trends, sales models and sales of top countries in the global Coronary Artery Disease Treatment Devices market. The report focuses on well-known providers in the global Coronary Artery Disease Treatment Devices industry, market segments, competition, and the macro environment. Under COVID-19 Outbreak, how the Coronary Artery Disease Treatment Devices Industry will develop is also analyzed in detail in Chapter 1.7 of the report. In Chapter 2.4, we analyzed industry trends in the context of COVID-19. In Chapter 3.5, we analyzed the impact of COVID-19 on the product industry chain based on the upstream and downstream markets. In Chapters 6 to 10 of the

Definition of coronary artery disease in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is coronary artery disease? Meaning of coronary artery disease as a finance term. What does coronary artery disease mean in finance?

TY - JOUR. T1 - Cardiocirculatory effects of beta-adrenergic blockade in coronary artery disease at rest and during upright exercise. T2 - comparison of acebutolol and propranolol. AU - Kaku, R.. AU - Lee, G.. AU - Amsterdam, Ezra A. PY - 1978. Y1 - 1978. UR - http://www.scopus.com/inward/record.url?scp=0017812111&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0017812111&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0017812111. VL - 26. JO - Journal of Investigative Medicine. JF - Journal of Investigative Medicine. SN - 1081-5589. IS - 2. ER - ...

The role of vaspin in the pathogenesis of stable coronary artery disease (SCAD) have been repeatedly addressed in clinical studies. However, from the point of view of clinical practice, the results of earlier studies are still inconclusive. The data of 106 SCAD patients who received coronary angiography and 85 coronary artery disease-free controls were collected and analysed. The patients were divided into subgroups according to their pre-test probability (PTP) and according to the result of coronary angiography. Fasting vaspin concentrations were compared between subgroups of SCAD patients and between target group and controls. The effect of age and smoking on the result of coronary angiography was compared to the effect of vaspin using the binomial regression. We did not find significant difference in vaspin level between target group and controls. Unless the pre-test probability was taken into account, we did not find vaspin difference in the target group, when dividing patients on the basis of

Chaikriangkrai, K.; Palamaner Subash Shantha, G.; Jhun, H.Yeon.; Ungprasert, P.; Sigurdsson, G.; Nabi, F.; Mahmarian, J.J.; Chang, S.Min., 2016: Prognostic Value of Coronary Artery Calcium Score in Acute Chest Pain Patients Without Known Coronary Artery Disease: Systematic Review and Meta-analysis

TY - JOUR. T1 - Algorithm to predict triple-vessel/left main coronary artery disease in patients without myocardial infarction. T2 - An international cross validation. AU - Detrano, Robert. AU - Jánosi, A.. AU - Steinbrunn, Walter. AU - Pfisterer, Matthias. AU - Schmid, Johann Jakob. AU - Maggie Meyer, M.. AU - Guppy, Kern H.. AU - Abi-Mansour, Pierre. PY - 1991. Y1 - 1991. N2 - Logistic regression was applied to the clinical, risk factor, and exercise data of consecutive angiographic referrals without prior myocardial infarction to determine an algorithm predicting the probability of triple-vessel/left main coronary artery disease. These data were obtained from a total of 1,074 such subjects from patient populations at four centers (Cleveland Clinic Foundation, Cleveland, Ohio; Hungarian Institute of Cardiology, Budapest, Hungary; the university hospitals, Zurich and Basel, Switzerland; and the Veterans Administration Medical Center, Long Beach, Calif.) and used to derive four separate ...

Treatment options for patients with left main coronary artery disease.. Rev Cardiovasc Med. 2011;12(2):e77-83. Authors: Lee MS, Nguyen J. Coronary artery bypass grafting (CABG) is the gold standard for the treatment of left main disease, whereas percutaneous coronary intervention is a viable option for patients who are candidates for revascularization but ineligible for CABG. CABG is limited by extended hospital stay followed by rehabilitation and mediocre long-term patency of saphenous vein grafts. Drug-eluting stents decrease the restenosis rates compared with bare metal stents and provide comparable clinical outcomes with those of CABG. Patients with isolated left main disease limited to the ostium or midbody are most likely to have good clinical outcomes with low restenosis and stent thrombosis rates. The results of the ongoing EXCEL trial, which compares left main percutaneous coronary intervention with drug-eluting stents and CABG, will provide insight regarding the ideal revascularization ...

Association of epicardial fat, hypertension, subclinical coronary artery disease, and metabolic syndrome with left ventricular diastolic dysfunction

TY - JOUR. T1 - ACR appropriateness criteria chronic chest pain - Low to intermediate probability of coronary artery disease. AU - Woodard, Pamela K.. AU - White, Richard D.. AU - Abbara, Suhny. AU - Araoz, Philip A.. AU - Cury, Ricardo C.. AU - Dorbala, Sharmila. AU - Earls, James P.. AU - Hoffmann, Udo. AU - Hsu, Joe Y.. AU - Jacobs, Jill E.. AU - Javidan-Nejad, Cylen. AU - Krishnamurthy, Rajesh. AU - Mammen, Leena. AU - Martin, Edward T.. AU - Ryan, Thomas. AU - Shah, Amar B.. AU - Steiner, Robert M.. AU - Vogel-Claussen, Jens. AU - White, Charles S.. PY - 2013. Y1 - 2013. N2 - Chronic chest pain can arise from a variety of etiologies. However, of those potential causes, the most life-threatening include cardiac disease. Chronic cardiac chest pain may be caused either by ischemia or atherosclerotic coronary artery disease or by other cardiac-related etiologies, such as pericardial disease. To consider in patients, especially those who are at low risk for coronary artery disease, are ...

The global Coronary Artery Disease Therapeutics Market report offers precise analytical information about the Coronary Artery Disease Therapeutics market. The market experts and proficient analysts generate the information based on the past and current situation of Coronary Artery Disease Therapeutics market, various factors affecting the growth trajectory, global sales, demand, total revenue generated, and capitalization of the market. Moreover, the report delivers a summarized assessment of the impact of federal policies and regulations on market operations. It also comprises detailed information pertaining to the Coronary Artery Disease Therapeutics markets current dynamics. The global Coronary Artery Disease Therapeutics market acts as a huge platform that offers several opportunities for many reputed firms, organizations, manufacturers, vendors, and suppliers AstraZeneca, Gilead, Novartis, Pfizer, Bayer, Bristol-Myers Squibb, GlaxoSmithKline, Merck, Mylan, Teva Pharmaceutical Industries ...

Title: Surgical or Interventional Revascularization in Diabetic Patients with Coronary Artery Disease?. VOLUME: 6 ISSUE: 6. Author(s):E. Apostolakis, I. Koniari, D. Velissaris and Efstratios N. Koletsis. Affiliation:Department of Cardiothoracic Surgery, Department of Anaesthesiology and ICU, University of Patras, Patras, Greece.. Keywords:Coronary artery disease, Diabetes mellitus, Coronary artery bypass grafting, Percutaneous transluminal coronary angioplasty, Myocardial infarction, Revascularization, percutaneous transluminal, Surgical revascularization, prothrombotic situation, lipoproteins, manifestations, triglyceride-rich, triggering mechanisms, Plaque-angiogenesis, catabolism, CABG surgery, Abciximab, ischemia, SPECT, AWESOME, worsening symptoms, BASKET-LATE, MACE, perioperatively. Abstract: The combination of diabetes mellitus and coronary artery disease (CAD) constitutes an aggressive disease characterized biologically by chronic inflammatory, proliferative and pro-thrombotic situation. ...

This stock medical exhibit depicts coronary artery disease. The first image shows the normal anatomy of the heart and coronary arteries. The remaining images show cross-sectional views of the arteries. The first has a normal, open lumen. The remaining three have various degrees of stenosis/thrombosis.

OBJECTIVE: Increased levels of lipoprotein(a) are a highly heritable risk factor for coronary artery disease (CAD). The genetic determinants of lipoprotein(a) levels are mainly because of genetic variation in the apolipoprotein(a) gene (LPA). We have tested the association of a relatively common null allele of LPA with lipoprotein(a) levels and CAD risk in a large case-control cohort. We have also examined how null allele genotyping complements apolipoprotein(a) isoform typing to refine the relationship between LPA isoform size and circulating lipoprotein(a) levels. APPROACH AND RESULTS: The LPA null allele (rs41272114) was genotyped in the PROCARDIS (Precocious Coronary Artery Disease) case-control cohort (4073 CAD cases and 4225 controls). Lipoprotein(a) levels were measured in 909 CAD cases and 922 controls; apolipoprotein(a) isoform size was estimated using sodium dodecyl sulfate-agarose gel electrophoresis and a high-throughput quantitative polymerase chain reaction-based method. Null carriers are

Abstract:. Background: Type 2 diabetes mellitus is often associated with severe Coronary artery disease (CAD). Since patients with higher risk of severe disease are likely to get better benefit from aggressive management, it is essential to identify factors which are associated with severe macrovascular disease. We looked at the possibility of hyperinsulinemia being a marker for severe and complex coronary artery disease in type 2 diabetes mellitus, to select patients who would benefit from aggressive treatment. Methods: A cross sectional study of 290 type 2 diabetic patients, who underwent coronary angiogram for the evaluation of clinically suspected CAD at a tertiary care hospital were recruited. Biochemical and anthropometric parameters were analysed. Insulin resistance was measured by homeostasis model assessment method. Angiographically measured syntax score of more than 22 is considered to be severe and complex CAD. Receiver operating curve characteristic was performed to find out the ...

Abstract:. Background: Non-communicable diseases constitute about 68% of global death annually. Among NCD deaths, cardiovascular diseases (CVD) ranks first with a share of 46.2% amounting to 17.5 million deaths. First degree relatives of patients with coronary heart disease have a higher risk of getting cardiovascular events due to interplay between genetic as well as environmental factors. The aim of this research WAS to assess the prevalence of Cardiovascular Disease (CVD) risk factors and to estimate the cardiovascular risk among first degree relatives of CAD patients. Methodology: A cross-sectional study was performed in first degree relatives of coronary artery disease patients in cardiology ward of JIPMER a tertiary care hospital in Puducherry. Overall 218 first degree relatives aged ≥18 were involved in study. The desired information was obtained using a pre-tested questionnaire and participants were also subjected to anthropometric measurements and laboratory investigations. WHO/ISH ...

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Background. Diverse ethnic groups may differ regarding the risk factors and severity of coronary artery disease (CAD). This study sought to assess the association between ethnicity and CAD risk and severity in six major Iranian ethnic groups.. Methods. In this study, 20,165 documented coronary artery disease patients who underwent coronary angiography at a tertiary referral heart center were recruited. The demographic, laboratory, clinical, and risk factor data of all the patients were retrieved. The Gensini score (an indicator of CAD severity) was calculated for all, and the risk factors and severity of CAD were compared between the ethnical groups, using adjusted standardized residuals, Kruskal-Wallis test, and multivariable regression analysis.. Results. The mean age of the participants (14,131 [70.1%] men and 6034 [29.9%] women) was 60.7 ± 10.8 years. The Fars (8.7%) and Gilak (8.6%) ethnic groups had the highest prevalence of ≥4 simultaneous risk factors. The mean Gensini score was the ...

Coronary arteries supply oxygen-rich blood to the heart muscle. Coronary artery disease results from atherosclerosis, a buildup of fatty deposits and plaque in the lining of a coronary artery, which narrows the artery and causes a decrease in blood flow to the heart muscle.. When a coronary artery suddenly becomes blocked and blood flow to an area of heart muscle stops, it is called a heart attack. A heart attack can permanently damage heart muscle and cause the affected area of the heart not to pump properly.. Common symptoms of coronary artery disease include shortness of breath and angina (pain or a feeling of increased pressure in the chest). Less common symptoms include nausea, sweating, fatigue, dizziness and decreased exercise tolerance.. In addition to diet, exercise, medication therapy and coronary artery bypass graft (CABG) surgery there are a number of minimally invasive procedures that can restore blood flow through a blocked coronary artery. These procedures include:. ...

Ling Jun Chen, Mercer University College of Pharmacy Coronary artery disease leads to the narrowing of coronary arteries and is associated with risk factors that include cigarette smoking, hypertension, hyperlipidemia, and diabetes. [1] European and U.S. guidelines have declared that patients with coronary artery disease have an increased risk of developing ischemia and infarction. Coronary-artery…

Polymorphisms in paraoxonase 1 (PON1) coding for PON1 enzyme have been studied as genetic markers of coronary artery disease (CAD). PON1 Q192R and PON1 L55M polymorphisms have been analyzed extensively, but data on association and role of these polymorphisms in the etiology of CAD are conflicting. In this study, we tested the genetic association between PON1 Q192R and PON1 L55M polymorphisms and CAD among north Indians. MATERIALS AND METHODS: Two hundred eighty-five angiographically proven patients with coronary artery disease and 200 sex-matched and ethnically matched controls were genotyped for 2 PON1 polymorphisms by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Genotype/ allele frequencies were compared in patients and controls using the chi-square test. RESULTS: At PON1-192 locus, there were significant differences between patients and controls (P, 0.05), leading to significant odds ratios for RR genotype (OR= 1.92, CI: 1.19-3.10) and *R allele ...

Motlagh B, ODonnell M, Yusuf S. Prevalence of cardiovascular risk factors in the Middle East: a systematic review. Eur J Cardiovasc Prev Rehabilm2009;16(3):268-80. Cole JH, Sperling LS. Premature coronary artery disease:clinical risk factors and prognosis. Curr Atheroscler Rep2004;6(2):121-5. Roest AM, Zuidersma M, de Jonge P. Myocardial infarction and generalized anxiety disorder: a 10-year follow-up. Br J Psychiatry 2012;200(4):324-9. Martens EJ, de Jonge P, Na B, et al. Scared to death? Generalized anxiety disorder and cardiovascular events in patients with stable coronary heart disease: The Heart and Soul Study. Arch Gen Psychiatry 2010;67(7):750-8. Huffman JC, Smith FA, Blais MA, et al. Anxiety, independent of depressive symptoms, is associated with in-hospital cardiac complications after acute myocardial infarction. J Psychosom Res 2008;65(6):557-63. Kawachi I, Sparrow D, Vokonas PS, et al. Symptoms of anxiety and risk of coronary heart disease. The NormativeAging Study. Circulation ...

TY - JOUR. T1 - Usefulness of myocardial perfusion echocardiography to identify obstructive coronary artery disease in patients with abnormal ventricular septal motion. AU - Spevack, Daniel M.. AU - Shoyeb, Abu. AU - Yoon, Andrew J.. AU - Gordon, Garet M.. AU - Matros, Todd. AU - Reynolds, Harmony A.. AU - Shah, Alan. AU - Tunick, Paul A.. AU - Kronzon, Itzhak. PY - 2005/4/1. Y1 - 2005/4/1. N2 - Twenty-three patients who had septal wall motion abnormalities and who underwent angiography within 2 weeks were evaluated by myocardial perfusion echocardiography. Mean perfusion score (plateau video intensity times the wash-in rate) was lower in segments that were supplied by obstructed coronary arteries in real time (7.5 vs 22.6 dB/s, p ,0.005) and with end-systolic triggering (8.6 vs 20.9 dB/s, p ,0.001). Lower mean septal perfusion scores (,12 dB/s) were seen in 14 of 16 patients who had obstructive septal coronary artery disease, and normal mean septal perfusion scores were seen in 6 of 7 patients ...

Insulin-resistance is associated with cardiovascular disease but it is not used as a marker for disease in clinical practice. To study the association between the homeostatic model assessment (HOMA-IR) and triglyceride/HDLc ratio (TG/HDLc) with the presence of coronary artery disease in patients submitted to cardiac catheterization. In a cross-sectional study, 131 patients (57.0 ± 10 years-old, 51.5% men) underwent clinical, laboratory and angiographic evaluation and were classified as No CAD (absence of coronary artery disease) or CAD (stenosis of more than 30% in at least one major coronary artery). Prevalence of coronary artery disease was 56.7%. HOMA-IR and TG/HDLc index were higher in the CAD vs No CAD group, respectively: HOMA-IR: 3.19 (1.70-5.62) vs. 2.33 (1.44-4.06), p = 0.015 and TG/HDLc: 3.20 (2.38-5.59) vs. 2.80 (1.98-4.59) p = 0.045) - median (p25-75). After a ROC curve analysis, cut-off values were selected based on the best positive predictive value for each variable: HOMA-IR = 6.0, TG

Insulin-resistance is associated with cardiovascular disease but it is not used as a marker for disease in clinical practice. To study the association between the homeostatic model assessment (HOMA-IR) and triglyceride/HDLc ratio (TG/HDLc) with the presence of coronary artery disease in patients submitted to cardiac catheterization. In a cross-sectional study, 131 patients (57.0 ± 10 years-old, 51.5% men) underwent clinical, laboratory and angiographic evaluation and were classified as No CAD (absence of coronary artery disease) or CAD (stenosis of more than 30% in at least one major coronary artery). Prevalence of coronary artery disease was 56.7%. HOMA-IR and TG/HDLc index were higher in the CAD vs No CAD group, respectively: HOMA-IR: 3.19 (1.70-5.62) vs. 2.33 (1.44-4.06), p = 0.015 and TG/HDLc: 3.20 (2.38-5.59) vs. 2.80 (1.98-4.59) p = 0.045) - median (p25-75). After a ROC curve analysis, cut-off values were selected based on the best positive predictive value for each variable: HOMA-IR = 6.0, TG

To evaluate the effectiveness of the graded exercise test in predicting the extent of coronary artery disease and the degree of left ventricular dysfunction in patients with prior myocardial infarction, 100 consecutive patients underwent both graded exercise testing and coronary and left ventricular angiography at a median of 4 months after infarction. The studies caused no complications. An equal number of patients had anterior and inferior infarction. Coronary artery disease, defined as 70 percent or greater stenosis of luminal diameter, was present in three vessels in 31 patients, in two vessels in 35 patients, in one vessel in 33 patients and in no vessel in one patient. With diagnostic electrocardiographic criteria of 1 mm or greater J point depression plus a flat or downsloping S-T segment, 31 patients had an electrocardiographically positive exercise test; 27 of these (87 percent) had two or three vessel coronary artery disease. Of the 21 patients with a negative exercise test, 62 ...

Coronary calcium score is an independent predictor of risk of significant coronary artery disease. It may refine overall risk of coronary artery disease estimated with conventional risk factors. It is based on CT examination and calculation of the Agatston score from the images.

Medical Management Of Stable Coronary Artery Disease ,Stable Coronary Artery Disease (Management patients with stable known or suspected

In this 2-center study of 2,583 consecutive patients without prior known CAD and without obstructive CAD, nonobstructive coronary artery plaque presence and extent as identified by 64-detector row CCTA are associated with heightened mortality risk in a 3-year follow-up period. The CCTA nonobstructive plaque assessment added significant risk prediction beyond patient demographic data, traditional CAD risk factors, and Framingham risk score.. The results of the present study suggest a potential utility for diagnosis of nonobstructive CAD by CCTA. Such patients experience heightened mortality risk, even though they represent a patient population for whom functional stress testing would be expected to be negative and who might not be referred for evaluation by invasive coronary angiography (ICA) after CCTA. Our results confirm prior observations of a high negative predictive value of a normal CCTA for later adverse clinical events but are additive to the prior published reports by identifying a ...

The use of non-invasive imaging to identify ruptured or high-risk coronary atherosclerotic plaques would represent a major clinical advance for prevention and treatment of coronary artery disease. We used combined PET and CT to identify ruptured and

TY - CONF AU - Kotur-Stevuljević, Jelena AU - Vemić, Sava AU - Spasojević-Kalimanovska, Vesna AU - Spasić, S. AU - Jelić-Ivanović, Zorana PY - 2009 UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/1277 PB - Taylor & Francis Ltd, Abingdon C3 - Free Radical Research T1 - Association of prooxidative-antioxidative balance (PAB) with inflammation markers in coronary artery disease patients VL - 43 SP - 96 EP - 97 ER ...

Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.

Change in R wave amplitude (mean delta R) was measured sequentially during and after 12 lead maximal treadmill exercise tests in 14 subjects with normal coronary arteries and 62 patients with coronary artery disease. In normal subjects mean delta R decreased maximally one minute after exercise and returned to control levels within three minutes. In contrast, mean delta R increased in patients with coronary artery disease, the greatest change occurring in patients with either triple vessel or left main disease or those with an akinetic region on the left ventriculogram. R wave amplitude returned to resting levels in five minutes. Increase in R wave amplitude was not directly related to changes in the ST segment. Changes in R wave amplitude during maximal treadmill exercise may improve the discrimination between patients with and without coronary artery disease and may help to identify those patients with abnormal left ventricular function. ...

BACKGROUND: Coronary artery disease is a major cause of morbidity and mortality worldwide, and is a consequence of acute thrombotic events involving activation of platelets and coagulation proteins. Factor Xa inhibitors and aspirin each reduce thrombotic events but have not yet been tested in combination or against each other in patients with stable coronary artery disease. METHODS: In this multicentre, double-blind, randomised, placebo-controlled, outpatient trial, patients with stable coronary artery disease or peripheral artery disease were recruited at 602 hospitals, clinics, or community centres in 33 countries. This paper reports on patients with coronary artery disease. Eligible patients with coronary artery disease had to have had a myocardial infarction in the past 20 years, multi-vessel coronary artery disease, history of stable or unstable angina, previous multi-vessel percutaneous coronary intervention, or previous multi-vessel coronary artery bypass graft surgery. After a 30-day run ...

The purpose of this study is to determine whether the safety and efficacy of coronary stent implantation using Everolimus-Eluting Coronary Stent System (Abbott, Boston Scientific) is not inferior to coronary artery bypass grafting (CABG) for the treatment of patient with multivessel coronary artery disease (CAD ...

Coronary artery disease may be the leading global reason behind mortality. the best global reason behind mortality.2 A lot more than 900,000 individuals in america are affected a myocardial infarction (coronary attack) or die of CAD this season.3 Package 1 , The pathophysiology and 38390-45-3 manufacture treatment of coronary artery disease Coronary artery disease (CAD) identifies the build-up of atherosclerotic plaque in the arteries that supply air and nutrients towards the center (examined in REF 127). The complicated procedure for atherosclerosis starts early in existence and is considered to initiate with dysfunction of endothelial cells that collection the coronary arteries; these cells are no more able to properly regulate vascular firmness (narrowing or constriction from the vessels) with nitric oxide signalling. Intensifying infiltration from the vessel wall structure by lipoprotein contaminants transporting cholesterol propagates an inflammatory response by cholesterol-loaded ...