TY - JOUR. T1 - A fundamental study for quantitative measurement of ultrasound contrast concentration by low mechanical index contrast ultrasonography. AU - Yamada, Satoshi. AU - Komuro, Kaoru. AU - Taniguchi, Mariko. AU - Uranishi, Ayumi. AU - Komatsu, Hiroshi. AU - Asanuma, Toshihiko. AU - Ishikura, Fuminobu. AU - Onozuka, Hisao. AU - Mikami, Taisei. AU - Tsutsui, Hiroyuki. AU - Beppu, Shintaro. PY - 2006/6. Y1 - 2006/6. N2 - Purpose. In high mechanical index (MI) contrast ultrasonography it has been shown that the power of contrast signal intensity (CI) has a strong linear correlation with the concentration of the ultrasound contrast agent under conditions of constant applied acoustic pressure. However, it is unclear whether the linearity is preserved in low-MI contrast ultrasonography. Thus, we investigated the relationship between ultrasound contrast concentration and CI in vitro. Methods. Solutions of the ultrasound contrast agents Definity and Imagent were prepared at concentrations of ...
Contrast Media/Contrast Agents Market By Type (Microbubble Contrast Media, Iodinated Contrast Media, Gadolinium-Based Contrast Media and Barium-Based Contrast Media), Modality (X-Ray/CT Contrast Agents, Ultrasound Contrast Agents and MRI Contrast Agents) and Application (Musculoskeletal Disorders, Cardiovascular Disorders, Nephrological Disorders, Neurological Disorders, Cancer, Gastrointestinal Disorders and Other Applications) - Global Industry Analysis And Forecast To 2025
PURPOSE:. To investigate the possibility of detecting cardiac transplant rejection and determining its degree of severity with magnetic resonance (MR) imaging with a blood pool contrast agent.. MATERIALS AND METHODS:. Rat allogeneic (PVG to Wistar/Kyoto, n = 9) and syngeneic (Wistar/Kyoto to Wistar/Kyoto, n = 6) heterotopic heart transplantations were performed. On the 2nd and 6th postoperative days, an ultrasmall superparamagnetic iron oxide, or USPIO, contrast agent was injected intravenously at a dose of 2 mg of iron per kilogram of body weight. The injection was followed by three-dimensional T1-weighted MR imaging of the heart grafts with an imaging time of approximately 2 minutes for each image for 44 minutes. The signal intensity (SI) was measured in the myocardium over time, and the relative enhancement was calculated. After the 6th day, the rats were sacrificed, and the morphology of the transplanted hearts was assessed histologically. The CIs for the difference of the means on day 2 and ...
TY - JOUR. T1 - Liver perfusion changes occurring during pancreatic islet engraftment. T2 - A dynamic contrast-enhanced magnetic resonance study. AU - Esposito, A.. AU - Palmisano, A.. AU - Maffi, P.. AU - Malosio, M. L.. AU - Nano, R.. AU - Canu, T.. AU - De Cobelli, F.. AU - Piemonti, L.. AU - Ironi, G.. AU - Secchi, A.. AU - Del Maschio, A.. PY - 2014/1. Y1 - 2014/1. N2 - The aim of this study was to investigate liver microvascular adaptation following the intraportal infusion of pancreatic islets (pancreatic islet transplantation [islet-tx]) in diabetic patients using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). DCE-MRI was performed before and 7 days after islet-tx in six diabetic patients. Initial area under curve (AUC60) and volume transfer coefficient (Ktrans) were assessed as markers of liver perfusion. Clinical and metabolic monthly follow-up was performed in all patients, considering fasting C-peptide and β-score as main indices of graft function. High variability ...
TY - JOUR. T1 - Antiangiogenic therapy for primary liver cancer. T2 - Correlation of changes in dynamic contrast-enhanced magnetic resonance imaging with tissue hypoxia markers and clinical response. AU - Yopp, Adam C.. AU - Schwartz, Lawrence H.. AU - Kemeny, Nancy. AU - Gultekin, David H.. AU - Gönen, Mithat. AU - Bamboat, Zubin. AU - Shia, Jinru. AU - Haviland, Dana. AU - DAngelica, Michael I.. AU - Fong, Yuman. AU - Dematteo, Ronald P.. AU - Allen, Peter J.. AU - Jarnagin, William R.. PY - 2011/8/1. Y1 - 2011/8/1. N2 - Background: This study utilized the imaging data of primary liver cancer (PLC) treated with floxuridine (FUDR) and bevacizumab to test the hypothesis that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters correlate with tissue hypoxia markers and treatment outcome. Methods: Seventeen patients with PLC were treated with hepatic artery infusional (HAI) FUDR for 14 days followed by systemic bevacizumab therapy. DCE-MRI images were obtained at baseline ...
Some patients will experience stinging or burning, but other patients will have little to no immediate discomfort. Clinical risk associated with contrast angiography in metformin treated patients: a clinical review. The Iodinated Contrast Media Guideline is intended to assist RANZCR, its staff, Fellows, members and other individuals involved in the administration of iodinated contrast media to patients undergoing medical imaging procedures. The aim of the Part 1 of Safe Use of Iodine-containing Contrast Media guidelines is to critically review the present recent evidence with the above trend in mind, and try to formulate new practical guidelines for all hospital physicians to provide the safe use of contrast media in diagnostic and interventional studies. These revised guidelines are necessary because of the ever-changing literature about both iodinated contrast media and gadolinium-based contrast agents (GBCAs). Metformin and contrast media: where is the conflict? Henrik S. Thomsen. All those ...
RISKS OF GADOLINIUM-BASED MRI INTRAVENOUS CONTRAST AGENTS answers are found in the Guide to Diagnostic Tests powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
This study intends to assess the ability of contrast-enhanced ultrasound in the detection of benign and malignant ovarian masses compared to unenhanced ultrasound.. By using an intravascular contrast agent, this noninvasive and feasible imaging technique will allow the investigators to define specific microcirculation patterns in 100 women with ovarian lesions.. The intravascular contrast agent properties will be compared between benign and malignant adnexal masses.. The final purpose of this ultrasonography is to allow the early detection of tumors and to improve the characterization between benign and malignant lesions. ...
TY - JOUR. T1 - Reactions to intravenous contrast media. T2 - Part I: Severe and fatal cardiovascular reactions in a canine dehydration model. AU - Katzberg, Richard W. AU - Morris, T. W.. AU - Schulman, G.. AU - Faillace, R. T.. AU - Boylan, L. M.. AU - Foley, M. J.. AU - Spataro, R. F.. AU - Fischer, H. W.. PY - 1983. Y1 - 1983. N2 - Investigations into the nature of severe and fatal reactions to contrast media have been severely limited by their unpredictable occurrence in the clinical setting and the absence of suitable laboratory models. The authors report their experience with a canine dehydration model. Intravenous administration of 2 ml/kg of 76% sodium methylglucamine diatrizoate resulted in vomiting, shock, inappropriate slowing of the heart rate, and death. ECG findings indicated suppression of sinoatrial node automaticity, a decrease in the rate of atrioventricular conduction, and depression of myocardial contractility. These results suggest two possible mechanisms: (a) enhanced ...
RISKS OF IODINATED CT INTRAVENOUS CONTRAST AGENTS answers are found in the Guide to Diagnostic Tests powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
Differential MR delayed enhancement patterns of chronic myocardial infarction between extracellular and intravascular contrast media
TY - GEN. T1 - Segmentation and classification of breast tumor using dynamic contrast-enhanced MR images. AU - Zheng, Yuanjie. AU - Baloch, Sajjad. AU - Englander, Sarah. AU - Schnall, Mitchell D.. AU - Shen, Dinggang. PY - 2007/12/1. Y1 - 2007/12/1. N2 - Accuracy of automatic cancer diagnosis is largely determined by two factors, namely, the precision of tumor segmentation, and the suitability of extracted features for discrimination between malignancy and benignancy. In this paper, we propose a new framework for accurate characterization of tumors in contrast enhanced MR images. First, a new graph cut based segmentation algorithm is developed for refining coarse manual segmentation, which allows precise identification of tumor regions. Second, by considering serial contrast-enhanced images as a single spatio-temporal image, a spatio-temporal model of segmented tumor is constructed to extract Spatio-Temporal Enhancement Patterns (STEPs). STEPs are designed to capture not only dynamic ...
TY - JOUR. T1 - Quantitative parameters in dynamic contrast-enhanced magnetic resonance imaging for the detection and characterization of prostate cancer. AU - Wei, Cheng. AU - Jin, Bowen. AU - Szewczyk-Bieda, Magdalena. AU - Gandy, Stephen. AU - Lang, Stephen. AU - Zhang, Yilong. AU - Huang, Zhihong. AU - Nabi, Ghulam. PY - 2018/3/23. Y1 - 2018/3/23. N2 - Objectives: to assess the diagnostic accuracy of quantitative parameters of DCE-MRI in multi-parametric MRI (mpMRI) in comparison to the histopathology (including Gleason grade) of prostate cancer.Patients and methods: 150 men with suspected prostate cancer (abnormal digital rectum examination and or elevated prostate-specific antigen) received pre-biopsy 3T mpMRI and were recruited into peer-reviewed, protocol-based prospective study. The DCE-MRI quantitative parameters (Ktrans (influx transfer constant) and kep (efflux rate constant)) of the cancerous and normal areas were recorded using four different kinetic models employing Olea Sphere ...
Summary:Intravenous contrast media, specifically the gadolinium chelates, are well accepted for use in the clinical practice of magnetic resonance imaging. The gadolinium chelates are considered to be very safe and lack (in intravenous use) the nephrotoxicity found with iodinated contrast media. Min
North America, Europe, Asia-Pacific, and Rest of the World (RoW) are the regions considered for a geographic analysis of the global contrast media/contrast agents market. North American contrast media/contrast agents market is expected to account for the largest share of the global contrast media/contrast agents market. However, the Asia Pacific contrast media/contrast agents market is expected to grow at the highest CAGR in the forecast period. This growth can be attributed to the increasing R&D investments and favorable demographic scenario in China, rising aging population and cancer incidence in Japan, growing investments in the Indian radiology market, and growing focus of market players & increasing government support in other APAC countries.. The prominent players in the global contrast media/contrast agents market include GE Healthcare (US), Bracco Imaging S.p.A. (Bracco) (Italy), Bayer HealthCare (Bayer) (Germany), and Guerbet Group (Guerbet) (France).. Don t miss out on business ...
The clinical pattern of diagnostic radiology has been made possible by progresss by diagnostic equipment and fact-finding techniques, as in the contrast media that permit visual image of the inside informations in the internal construction or variety meats that would non otherwise be incontrovertible. Contrast media can be categorized as drug because the can absorb into the systemic circulation and may impact a physiologic response.. When an anatomical country is filled or outlined by contrast media. The image appears to be white ( positive contrast ) but if it is a negative contrast it makes the organ appear darker. Contrast media are solution or either gasses introduced it to the organic structure to supply contrast between an anatomical organ and its environing tissues.. To increase the visibleness of the construction, Ba sulphate is used as a substance. The pick of contrast media is ever been debate affair but it is ever the duty of the radiotherapist to do a rational determination on choice ...
Antivascular treatments can either be antiangiogenic or targeting established tumour vasculature. These treatments affect the tumour microvasculature and microenvironment but may not change clinical measures like tumour volume and growth. In research on antivascular treatments, information on the tumour vasculature is therefore essential. Preclinical research is often used for optimization of antivascular drugs alone or in combined treatments. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is an in vivo imaging method providing vascular information, which has become an important tool in both preclinical and clinical research. This review discusses common DCE-MRI imaging protocols and analysis methods and provides an overview of preclinical research on antivascular treatments utilizing DCE-MRI.
Currently there are no approved biomarkers for the pre-symptomatic diagnosis of Alzheimers disease (AD). Cathepsin-D (Cat-D) is a lysosomal protease that is present at elevated levels in amyloid plaques and neurons in patients with AD and is also elevated in some cancers. We have developed a magnetic resonance imaging (MRI)/fluorescent contrast agent to detect Cat-D enzymatic activity. The purpose of this study was to investigate the cellular and tissue uptake of this MRI/fluorescent contrast agent. The agent consists of an MRI probe [DOTA-caged metal ion (Gd3+ or Tm3+)] and a fluorescent probe coupled to a cell-penetrating-peptide sequence by a Cat-D recognition site. The relaxivity of Gd3+-DOTA-CAT(cleaved) was measured in 10% heat-treated bovine serum albumin (BSA) phantoms to assess contrast efficacy at magnetic fields ranging from 0.24 mT to 9.4 T. In vitro, Tm3+-DOTA-CAT was added to neuronal SN56 cells over-expressing Cat-D and live-cell confocal microscropy was performed at 30 min. ...
Heterogeneity is a common finding within tumours. We evaluated the imaging features of tumours based on the decomposition of tumoural dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data to identify their prognostic value for breast cancer survival and to explore their biological importance. Imaging features (n = 14), such as texture, histogram distribution and morphological features, were extracted to determine their associations with recurrence-free survival (RFS) in patients in the training cohort (n = 61) from The Cancer Imaging Archive (TCIA). The prognostic value of the features was evaluated in an independent dataset of 173 patients (i.e. the reproducibility cohort) from the TCIA I-SPY 1 TRIAL dataset. Radiogenomic analysis was performed in an additional cohort, the radiogenomic cohort (n = 87), using DCE-MRI from TCGA-BRCA and corresponding gene expression data from The Cancer Genome Atlas (TCGA). The MRI tumour area was decomposed by convex analysis of mixtures (CAM), resulting
TY - JOUR. T1 - Glomerular filtration rate estimated after multiple injections of contrast medium during angiography. AU - Boijsen, M.. AU - Granerus, G.. AU - Jacobsson, L.. AU - Björneld, L.. AU - Aurell, M.. AU - Tylen, Ulf. PY - 1988. Y1 - 1988. N2 - In twenty-six patients referred for angiography, clearance of contrast medium was determined with x-ray fluorescence analysis after multiple injections of contrast medium. A formula for correction of the injected amount, which takes into consideration the different times of contrast medium injections, approximating the total injected amount into one injection, was used. A single injection clearance of 51Cr-EDTA was determined at the same time. the results showed a good correlation between the clearance of contrast medium after multiple injections and the 51Cr-EDTA clearance after a single injection (r=0.945). the correlation between contrast medium clearance calculated without correction for the different injection times, and 51Cr-EDTA ...
Abstract: Significant progress has been made in recent years in the development of effective ultrasonic contrast agents for inducing better image contrast of certain anatomic structures in the body for diagnostic purposes. An ideal ultrasonic contrast agent should have the following characteristics: (1) be nontoxic, (2) be capable of producing sufficient contrast via intravenous injection, and (3) have a long persistence time. Gaseous contrast agents such as Albunex[sup (registered)] (Molecular Biosystems), Echovist[sup (registered)] and Levovist[sup (registered)] (Schering), and EchoGen[sup (registered)] (Sonus) have been shown to satisfy a majority of these requirements. Albunex[sup (registered)] was approved in 1994 by the FDA for clinical use. The most intriguing application of these contrast agents is in harmonic pulse-echo and Doppler imaging since nonlinear resonance of microairbubbles would yield echoes at the harmonics of the incident frequency. If detection is made at one of these ...
Dynamic Contrast-Enhanced Magnetic Resonance Imaging As a Biomarker for the Pharmacological Response of PTK787/ZK 222584, an Inhibitor of the Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, in Patients With Advanced Colorectal Cancer and Liver Metastases: Results From Two Phase I ...
Optimized Fast Dynamic Contrast-Enhanced Magnetic Resonance Imaging of the Prostate Effect of Sampling Duration on Pharmacokinetic ...
Acute adverse reactions to contrast media will occur at a certain rate. Non-ionic iodinated contrast is said to have an adverse reaction rate of about 0.6 to 3.1% [6-10]. This rate is said to be about 0.07 to 0.67% for gadolinium contrast media [6-9].. The ACR Manual on Contrast Media [1] and EUSR Guidelines on Contrast Media [2] recommend premedication for patients at risk for adverse reactions to contrast, but the definition of at-risk has some variation among protocols and studies. The ACR Manual states patients with a history of adverse reactions should be premedicated, but does not elaborate on the degree of the reaction. The ESUR Guidelines, on the other hand, includes patients with a history of moderate or severe reactions. When following the ESUR Guidelines, patients with history of mild reactions to contrast undergo contrast enhanced examinations without premedication. (We chose to follow and reference the older versions of the ACR Manual and ESUR Guidelines, as these were the ones ...
The Global Contrast Media Market is going to continue with the same trends of growth during the forecast period. The major factors influencing the growth of the market include increasing technology advancement in contrast medium, increasing prevalence of cancer and cardiac diseases, growth in emerging markets for imaging technology, increasing demand for diagnostics, and image guide procedures and various others. Whereas, the risk of side effects and adverse effects of the contrast media may hamper the growth of the market. Exclusive Sample Copy @https://www.marketresearchfuture.com/sample_request/1284 .. Contrast media are substances which are utilized to improve the contrast of fluids in the body during medical imaging. It is basically used to enhance the visibility of blood vessels and GI tract. The global contrast media market is growing with the steady pace; mainly due to the increasing prevalence of different diseases such as GIT diseases and cardiac diseases. According to a recent study ...
Dynamic contrast-enhanced (DCE)-MRI is useful to assess the early effects of drugs acting on tumor vasculature, namely anti-angiogenic and vascular disrupting agents. Ultra-high-field MRI allows higher-resolution scanning for DCE-MRI while maintaining an adequate signal-to-noise ratio. However, increases in susceptibility effects, combined with decreases in longitudinal relaxivity of gadolinium-based contrast agents (GdCAs), make DCE-MRI more challenging at high field. The aim of this work was to explore the feasibility of using DCE-MRI at 11.7 T to assess the tumor hemodynamics of mice. Three GdCAs possessing different molecular weights (gadoterate: 560 Da, 0.29 mmol Gd/kg; p846: 3.5 kDa, 0.10 mmol Gd/kg; and p792: 6.47 kDa, 0.15 mmol Gd/kg) were compared to see the influence of the molecular weight in the highlight of the biologic effects induced by combretastatin A4 (CA4). Mice bearing transplantable liver tumor (TLT) hepatocarcinoma were divided into two groups (n = 5-6 per group and per ...
Envision uses non-ionic contrast media. This is the safest intravenous contrast media available.. Sometimes an injection of contrast media is indicated to enhance diagnostic accuracy of the examination and enhance the quality. Following an injection of contrast media, you may experience a sensation of heat, an unusual taste or smell and a tingling sensation in the pelvic area. These symptoms are common and very transient. The contrast is eliminated from the body by the kidneys and is excreted in the urine within hours of the initial injection. Patients are encouraged to drink additional clear fluids following their examination to assist in the filtration of the kidneys.. Occasionally, patients can experience minor allergic reactions such as hives. In rare cases, a major allergic reaction can occur. Envision staff are trained in the management of allergic reactions and all sites that administer intravenous contrast media are equipped with emergency medications and equipment, should a patient ...
TY - JOUR. T1 - Dynamic contrast-enhanced MRI in oncology: how we do it. T2 - Radiologia Medica. AU - Petralia, G.. AU - Summers, P.E.. AU - Agostini, A.. AU - Ambrosini, R.. AU - Cianci, R.. AU - Cristel, G.. AU - Calistri, L.. AU - Colagrande, S.. N1 - Export Date: 4 March 2021 CODEN: RAMEA Correspondence Address: Colagrande, S.; Struttura Complessa di Radiodiagnostica Universitaria (SOD 2), Largo Brambilla 3, Italy; email: [email protected] Chemicals/CAS: Contrast Media References: Hanahan, D., Weinberg, R., The hallmarks of cancer (2000) Cell, 144 (5), pp. 646-674; Radue, E.W., Kendall, B.E., Xenon enhancement in tumours and infarcts (1978) Neuroradiology, 16, pp. 224-227. , COI: 1:STN:280:DyaE1M7hsVykuw%3D%3D; Cherry, S.R., Carnochan, P., Babich, J.W., Serafini, F., Rowell, N.P., Watson, I.A., Quantitative in vivo measurements of tumor perfusion using rubidium-81 and positron emission tomography (1990) J Nucl Med, 31 (8), pp. 1307-1315. , COI: 1:CAS:528:DyaK3cXls1yiurg%3D, PID: ...
Although effective in promoting the prevention of SCD, current risk stratification strategies in HCM patients do not identify all at-risk patients, largely as a result of the substantial heterogeneity in clinical and phenotypic expression of this genetic disease.2,3,5,8,42 Because SCD can occur in HCM patients considered to be at low risk, identification of additional markers to allow more precise selection of those patients who may benefit from primary prevention ICD therapy represents a major clinical aspiration.3,28 Recently, considerable interest in using contrast-enhanced CMR to improve the risk stratification model has emerged.43-48 However, available data on the prognostic value of CMR do not provide an opportunity to specifically predict SCD risk for individual HCM patients.28,29 In the present large, multicenter HCM cohort, we have investigated LGE as a predictor of SCD and other adverse disease consequences among a predominantly lower-risk cohort of HCM patients.. Our data show that in ...
Contrast Media Injectors (Diagnostic Imaging) - Global Market Analysis and Forecast Model has complete details about market of Contrast Media Injectors (Diagnostic Imaging) industry, Contrast Media Injectors (Diagnostic Imaging) analysis and current trends. Contrast Media Injectors (Diagnostic Imaging) - Global Market Analysis and Forecast Model Summary Contrast Media Injectors (Diagnostic Imaging) - Global Market Analysis and Forecast Model is built to visualize quantitative market trends within Diagnostic Imaging therapeutic area. Contrast Media Injectors are devices used to inject contrast medi.
Early buyers will receive 10% customization on reports.. This report studies the global contrast media/contrast agentsmarket for the forecast period of 2016 to 2021. This market is expected to reach a value of USD 5.44 Billion by 2021, from an estimated value of USD 4.46 Billion in 2016, at a CAGR of 4.1%.. The prominent players in the global contrast media/contrast agents market include Bayer HealthCare (Germany), GE Healthcare (U.S.), Guerbet Group (France), and Bracco Imaging S.p.A. (Italy). These companies hold a dominant position in the contrast media/contrast agents market mainly due to their well-established presence in the field of genomics, presence in over 50 countries, high R&D investments, and strong sales and distribution force. Other players operating in this market include Lantheus Medical Imaging (U.S.), nanoPET Pharma GmbH (Germany), CMC Contrast AB (Sweden), Daiichi Sankyo (Japan), and Subhra Pharma Private Limited (India).. The global contrast media/contrast agentsmarket has ...
Dynamic susceptibility contrast (DSC) perfusion imaging has been in clinical use for various indications, including characterization and grading of intracranial neoplasms. However, several technical factors can lead to pitfalls in image interpretation. This review discusses the extraction of T1 and T2* information from mean curve analysis of DSC perfusion imaging of various brain tumors, which provides further insights into tumor biology and, thus, may be useful in the differential diagnosis of such tumors. Indeed, by looking at the mean time-signal intensity curve from the tumor bed in addition to the rCBV maps, it is possible to obtain further inferences of capillary density and lesion leakiness. When dynamic contrast enhanced (DCE) T1 perfusion is not available, DSC perfusion with mean curve analysis appears to be a valid alternative for characterizing various brain neoplasms in a routine clinical setting.. El texto completo de este artículo está disponible en PDF ...
A method was devised for obtaining dynamic contrast-enhanced T1-weighted and relaxation rate (delta R2*) images simultaneously to evaluate regional hemodynamics of the brain tumors. On a 1.5-T MR system, dual dynamic contrast-enhanced images were obtained using a gradient echo (dual echo fast field …
Many CT studies require intravenous contrast agent. This is a special fluid containing iodine that enhances the blood vessels and certain organs and allows them to be better visualised, highlighting any abnormalities. If your examination requires an intravenous contrast injection, you will be asked whether you have a history of allergies or asthma; and whether you are on diabetic medication. Oral contrast media are not usually required for CT studies of the brain and spine. ...
Pathologic hyperpermeability exists in the spectrum of disease states, including neuro-ischemic, neuro-inflammatory and neuro-oncological. To-date the characterization of disease pathology with T 1 -weighted quantitative dynamic contrast-enhanced magnetic resonance imaging has relied on the study of modeled microvascular parameters such as diseased tissue transvascular flow rates of small molecule paramagnetic imaging agents with short plasma half-lives, based on which it is difficult to assess the specific nature of the disease state. Another type of T 1 -weighted quantitative dynamic contrast-enhanced magnetic resonance imaging involves the use of paramagnetic heavy metal-chelated dendrimer nanoparticles that possess longer plasma half-lives with pre-determined molar relaxivities to quantitatively image concentration of macromolecular contrast agent accumulation over time in hyperpermeable pathology such as solid tumor tissue with the
OBJECTIVES The aim of this study was to investigate the feasibility of using contrast-enhanced ultrasound (CEUS) in experimental breast cancer bone metastases and its utilization for assessment of early antiangiogenic treatment response in these lesions. MATERIALS AND METHODS Nude rats bearing bone metastases (n = 20) were treated with the antiangiogenic tyrosine kinase inhibitor sunitinib daily from days 30 to 35 after MDA-MB-231 tumor cell inoculation (n = 10) and compared with sham-treated controls (n = 10). Imaging with ultrasound (US) and magnetic resonance imaging (MRI) was performed on days 30, 32, and 35 after tumor cell inoculation to determine tumor volume and parameters of vascularization in bone metastases. Contrast-enhanced US images were used to calculate wash-in and wash-out values, peak enhancement, and area under the curve from time intensity curves. In addition, a quantitative analysis software was used to determine regional blood volume and flow as well as filling times within bone
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ECCO - European Crohn´s and Colitis Organisation. The European Crohn\s and Colitis Organisation is a highly active non-profit association focusing on Inflammatory Bowel Diseases (IBD).
CMR adenosine first pass perfusion yields excellent results for the detection of significant coronary artery disease. As in patients after coronary artery bypass grafts (CABG) myocardial perfusion is more complex and additionally the kinetic of a first pass bolus may by altered due to different distances through the bypasses and/or native vessels, this patient group has been excluded from most published studies. Parameters like speed of contrast wash-in (upslope, time to 50% or peak enhancement) and peak enhancement are indirectly used for visual analysis and may be altered post CABG imitating perfusion defects without significant stenosis. In this case, adenosine perfusion would be an inadequate diagnostic test. ...
Microparticles which are less than 12 μm in size and are formed of or comprise a solid lipophilic group-containing compound having an HLB value less than about 20 produce a long lived ultrasonically echogenic entity in aqueous liquid and are useful as left heart ultrasonic contrast image enhancing agents. Contrast media for ultrasonic diagnostics comprising a liquid vehicle containing (a) suspended therein microparticles of a mixture of at least one (C8 -C20)-fatty acid and at least one solid that is not a surfactant and (b) microbubbles, are especially effective upon ultrasonic imaging after intravenous administration, for the contrasting of both the right heart and left heart, of the myocardium, as well as other organs, such as liver, spleen, and kidneys.
Absolute cerebral perfusion parameters were obtained by dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) carried out using different contrast-agent administration protocols. Sixteen healthy volunteers underwent three separate DSC-
Contrast-enhanced magnetic resonance angiography (MRA) employs the use of blood pool contrast agents (CA) such as gadolinium (Gd3+) complexes that allow for delayed phase arterial
View detailed Table of Content here - https://www.marketsandmarkets.com/Market-Reports/contrast-injector-market-96046959.html. The consumables segment accounted for the largest share of the contrast media injection market, by type, in 2019.. Based on the product, the contrast media injectors market is segmented into injector systems, consumables, and accessories. The injector systems market is segmented further into CT injectors, MRI injectors, Angiography injectors. The consumables segment is segmented further into syringes, tubes, other consumables. In 2019, the consumables segment accounted for the largest share of the contrast media injectors market. The large share of this segment can be attributed to the growing requirement of consumables to maintain safety and hygienic conditions during diagnostic procedures. These consumables need to be re-purchased for every new procedure, as opposed to instruments, thus driving its demand.. The interventional cardiology segment to register the highest ...
ESUR GUIDELINES ON CONTRAST MEDIA 7.0 PDF - ESUR GUIDELINE*: GADOLINIUM BASED. CONTRAST MEDIA AND NEPHROGENIC. SYSTEMIC Incidence of NSF: % in at-risk subjects. Contrast media · › Contrast media · ›
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Image acquisition strategies. Principal contrast mechanisms in MRI emerge from the relaxation properties of tissue water (or fat) hydrogen nuclei in the scanner magnetic field after undergoing radiofrequency excitation. These properties can be manipulated to reflect features of the molecular and physiologic environment of a tissue. T1-weighted images emphasize the rate (different for different tissue types) at which energy is redistributed between these nuclei and the tissue as a whole. T2*-weighted images emphasize the different rates at which the same nuclei lose phase coherence with one another and the way that this process is affected by local variations in field strength due to differences in magnetic susceptibility between tissues. Conventional gadolinium chelate-based contrast media affect T1-weighted images causing a signal increase, and T2*-weighted images causing a signal decrease.. Nearly all clinical DCE-MRI is done at 1.5 T. The data have a typical spatial resolution of a few ...
Dynamic Contrast-Enhanced Magnetic is now established as the methodology of choice for the assessment of tumor microcirculation in vivo. The method assists
Contrast-induced nephropathy (CIN) is defined as the impairment of renal function and is measured as either a 25% increase in serum creatinine (SCr) from baseline or 0.5 mg/dL (44 µmol/L) increase in absolute value, within 48-72 hours of intravenous contrast administration.
Objective. We aimed to determine whether contrast-enhanced ultrasonography can predict the effects of neoadjuvant chemotherapy on breast cancer.. Methods. The clinical responses of 63 consecutive patients with breast cancer (T1-4, N0-1, M0) to neoadjuvant chemotherapy between October 2012 and May 2015 were assessed using contrast-enhanced magnetic resonance imaging, positron emission tomography/computed tomography and contrast-enhanced ultrasonography. Perfusion parameters for contrast-enhanced ultrasonography were created from time-intensity curves based on enhancement intensity and temporal changes to objectively evaluate contrast-enhanced ultrasonography findings. The sensitivity, specificity and accuracy of contrast-enhanced ultrasonography, magnetic resonance imaging and positron emission tomography/computed tomography to predict a pathological complete response were compared after confirming the pathological findings of surgical specimens.. Results. Twenty-three (36.5%) of the 63 patients ...
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Contrast-induced acute kidney injury (CI-AKI), also known as contrast-induced nephropathy, is a common complication of intra-arterial administration of iodinated radiographic contrast medium (IRCM) that may prolong the duration of hospitalization and increase the risk of death (1,2). CI-AKI is characterized by an increase in serum creatinine beginning within the first 24 h of IRCM exposure and peaking at up to 5 days after exposure. CI-AKI is defined most commonly as a rise in serum creatinine concentration ≥0.5 mg/dl or 25% above baseline assessed 48 to 72 h after exposure to contrast (1,2). More recently, the Acute Kidney Injury Network defined CI-AKI as a rise in serum creatinine of ≥0.3 mg/dl above baseline with oliguria (1).. Patients with chronic kidney disease (CKD) are vulnerable to CI-AKI, particularly in the presence of risk factors such as diabetes mellitus and clinical states associated with decreased renal perfusion (1,2). McCullough (1) proposed a pathophysiologic sequence for ...
Hilmi Umut nal, Yal n Ba aran, Hadim Ako lu. Contrast-induced acute kidney injury/contrast-induced nephropathy may be related to additional risk factors. Anatol J Cardiol. 2018; 19(2): 155- ...
TY - JOUR. T1 - CT colonography with intravenous contrast material. T2 - Varied appearances of colorectal carcinoma. AU - Silva, Alvin C. AU - Hara, Amy K.. AU - Leighton, Jonathan A. AU - Heppell, Jacques P.. PY - 2005/9. Y1 - 2005/9. N2 - Computed tomographic (CT) colonography is a noninvasive, rapidly evolving technique that has been shown in some studies to be comparable with conventional colonoscopy for the screening of colorectal cancer. Because colorectal cancer has a widely varying appearance at both endoscopy and CT colonography, familiarity with the gamut of morphologic appearances can help improve interpretation of the results. The addition of intravenous contrast material to CT colonography can aid differentiation of true colonic masses from pseudolesions such as residual stool and improves the depiction of enhancing masses that might otherwise be obscured by residual colonic fluid. In contrast to staging of most other tumors, staging of colorectal carcinoma depends more on the depth ...
TY - JOUR. T1 - Measuring tumor perfusion in control and treated murine tumors. T2 - Correlation of microbubble contrast-enhanced sonography to dynamic contrast-enhanced magnetic resonance imaging and fluorodeoxyglucose positron emission tomography. AU - Niermann, Kenneth J.. AU - Fleischer, Arthur C.. AU - Huamani, Jessica. AU - Yankeelov, Thomas E.. AU - Kim, Dong W.. AU - Wilson, Wendy D.. AU - Hallahan, Dennis E.. PY - 2007/6. Y1 - 2007/6. N2 - Objective. The purpose of this study was to evaluate the ability of dynamic microbubble contrast-enhanced sonography (MCES), in comparison with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and fluorodeoxyglucose positron emission tomography (FDG-PET), to quantitatively characterize tumor perfusion in implanted murine tumors before and after treatment with a variety of regimens. Methods. Seventeen mice with Lewis lung carcinoma implants were categorized to control, radiation therapy alone, antiangiogenic chemotherapy alone, and ...
Adverse reactions to intravenous iodinated contrast media may be classified as general and organ-specific, such as contrast-induced nephrotoxicity. General adverse reactions may be subclassified into acute and delayed types. Acute general adverse reactions can range from transient minor reactions to life-threatening severe reactions. Non-ionic contrast media have lower risk of mild and moderate adverse reactions. However, the risk of fatal reactions is similar for ionic and non-ionic contrast media. Adequate preprocedure evaluation should be performed to identify predisposing risk factors. Prompt recognition and treatment of acute adverse reactions is crucial. Risk of contrast induced nephrotoxicity can be reduced by use of non-ionic contrast media, less volume of contrast, and adequate hydration. The radiologist can play a pivotal role by being aware of predisposing factors, clinical presentation, and management of adverse reactions to contrast media.
TY - JOUR. T1 - Intravenous contrast material exposure is not an independent risk factor for dialysis or mortality. AU - McDonald, Robert. AU - McDonald, Jennifer S. AU - Carter, Rickey E.. AU - Hartman, Robert P.. AU - Katzberg, Richard W.. AU - Kallmes, David F. AU - Williamson, Eric E.. PY - 2014/12/1. Y1 - 2014/12/1. N2 - Purpose: To determine the risk of emergent dialysis and short-term mortality following intravenous iodinated contrast material exposure.Materials and Methods: This single-center retrospective study was HIPAA compliant and institutional review board approved. All contrast material-enhanced (contrast group) and unenhanced (noncontrast group) abdominal, pelvic, and thoracic computed tomography scans from 2000-2010 were identified. Patients in the contrast and noncontrast groups were compared following propensity score-based 1:1 matching to reduce intergroup selection bias. Patients with preexisting diabetes mellitus, congestive heart failure, or chronic or acute renal failure ...
Barium Sulfate - solvaySolvay Fluorides, LLC does not sell barium sulfate directly to consumers. . odorless powder. . Exposure can occur at either a barium sulfate manufacturing facility, or . personal protective equipment such as gloves and boots, respiratory.barium sulfate powder production equipment barium sulfate powder production,Patent US4588574 - Process for the preparation of barium sulfate of .May 13, 1986 . Barium sulfate suitable for the preparation of radiographic contrast agents of . Try the new Google Patents, with machine-classified Google Scholar .. More specifically, the inventive process for producing barium sulfate which . Barium sulfate powder of a particle size of 1 to 3 μm is heated for 90 minutes ...
The iodine atom, with its relatively high atomic weight, attenuates x-rays and is used in most intravascular contrast agents today. Iodines K shell binding energy of 33.2 keV is ideal for x-ray photon absorption. Covalent bonding of 3 iodine atoms to a benzene ring at the 2, 4, and 6 position-the basic structure of all iodinated contrast agents (Fig. 18-1)-allows iodine to be delivered intravascularly, free of the side effects of free iodine, and also increases the effective molecular concentration of iodine, improving the ability to attenuate x-rays.1 An iodine concentration of 320 to 370 mg/mL is optimal for angiographic studies. Although all iodinated contrast agents use this basic benzene ring structure, the number of rings per molecule (monomers or dimers) and the side chains at the 1, 3, and 5 positions give each of them unique chemical properties.2 ...
Background: Efficacy of intravenous (IV) volume expansion in preventing contrast-induced acute kidney injury (CI-AKI) is well known. However, the role of oral hydration has not been well established. The aim of this work was to evaluate the efficacy of oral hydration in preventing CI-AKI. Methods: We prospectively randomized 225 patients undergoing coronary angiography and/or percutaneous coronary intervention in either oral hydration or IV hydration groups. Patients who have at least one of the high-risk factors for developing CI-AKI (advanced age, type 2 diabetes mellitus, anemia, hyperuricemia, a history of cardiac failure or systolic dysfunction) were included in the study. All patients had normal renal function or stage 1-2 chronic kidney disease. Patients in the oral hydration group were encouraged to drink unrestricted amounts of fluids freely whereas isotonic saline infusion was performed by the standard protocol in the IV hydration group. Results: CI-AKI occurred in 8/116 patients ...
Pharmacological interventions for the prevention of contrast-induced acute kidney injury in high-risk adult patients undergoing coronary angiography: a systematic review and meta-analysis of randomised controlled trials ...
TY - JOUR. T1 - Peripheral contrast-enhanced MR angiography at 3.0T, improved spatial resolution and low dose contrast. T2 - Initial clinical experience. AU - Nael, Kambiz. AU - Krishnam, Mayil. AU - Nael, Ali. AU - Ton, Anthony. AU - Ruehm, Stefan G.. AU - Finn, J. Paul. PY - 2008/7/14. Y1 - 2008/7/14. N2 - To investigate a high spatial resolution peripheral contrast-enhanced MR angiography (CE-MRA) protocol, applying a dedicated multi-channel array coil and accelerated parallel acquisition at 3.0T in evaluation of patients with peripheral vascular disease. Twenty patients with peripheral vascular disease underwent multi-station high spatial resolution peripheral CE-MRA at 3T. The image quality, presence of venous contamination, image noise, and artifact were evaluated by 2 radiologists independently. Assessment of arterial disease for 540 arterial segments was performed, and findings were correlated with conventional catheter angiography in 10 patients. All studies were yielded high diagnostic ...
TY - JOUR. T1 - Intraindividual comparison of high-spatial-resolution abdominal MR angiography at 1.5 T and 3.0 T. T2 - Initial experience. AU - Michaely, Henrik J.. AU - Kramer, Harald. AU - Dietrich, Olaf. AU - Nael, Kambiz. AU - Lodemann, Klaus Peter. AU - Reiser, Maximilian F.. AU - Schoenberg, Stefan O.. PY - 2007/9/1. Y1 - 2007/9/1. N2 - Purpose: To prospectively compare three-dimensional (3D) contrast material-enhanced abdominal magnetic resonance (MR) angiography at 1.5 and 3.0 T intraindividually in healthy volunteers. Materials and Methods: After institutional review board approval and informed consent were obtained, 15 healthy male volunteers (age range, 24-41 years) underwent one abdominal 3D contrast-enhanced MR angiographic examination each at 1.5 and 3.0 T in random order. Fast 3D gradient-echo sequence with parallel imaging acceleration factor of three was used for MR angiography; acquired spatial resolutions were 1 x 0.8 x 1 mm3 (imaging time, 19 seconds) at 1.5 T and 0.9 x 0.8 ...
Background: Myocardial late gadolinium enhancement (LGE) on Contrast-Enhanced Magnetic Resonance Imaging (CE-MRI) of patients (pts) with hypertrophic cardiomyopathy (HCM) may indicate intra-myocardial fibrosis. We explored whether the presence and extent of LGE on CE-MRI among pts with HCM predicted ventricular arrhythmogenicity, and decreased survival.. Methods: 424 HCM pts [age = 55 ± 16 years (range 2 - 90), 41% females], without prior history of septal ablation/myectomy, underwent CE-MRI (GE 1.5T) during a 6-year period. We compared the presence and amount of LGE with degree of ventricular ectopy on Holter ECG (available in 220 pts) recorded during the same time period of the CE-MRI. All cause death and appropriate, VF-terminating ICD therapies were then recorded during a mean follow-up of 34 ± 14 months (range 7 - 85).. Results: 239 pts (56%) had LGE ranging from 0.4 - 65% of the myocardium. LGE -positive pts were more likely to have non-sustained ventricular tachycardia on Holter ECG ...
Researchers examined iodinated contrast media use and allergic reactions in almost 200,000 patients. Family history as well as previous individual history of reaction to iodinated contrast agents suggests a genetic predisposition. Half of the approximately 88 million CT scans conducted each year in the U.S. include the use of iodinated contrast media.
The objective of our study was to investigate whether dynamic contrast-enhanced MRI (DCE-MRI) can detect differences and potential adaption in single-kidney parenchymal volume, blood flow, glomerular filtration rate (GFR), and filtration fraction in the remaining kidney of healthy donors compared with nondonors. Further, we evaluated the agreement in donor GFRs measured using DCE-MRI versus serum clearance of iohexol.. Twenty living kidney donors and 20 healthy control subjects underwent DCE-MRI and iohexol GFR. Renal parenchymal volume was assessed from maximum-signal-intensity maps. Single-kidney MRI measurements of blood flow and GFR were derived from parenchymal signal intensity-time curves fitted to a two-compartment filtration model. The Student t test, Pearson correlation coefficient, mean differences, and limits of agreement were applied to analyze MRI measurements between groups and agreement with iohexol GFR.. MRI findings showed significantly higher blood flow (difference in mean ...
Recent studies have suggested a low potential risk for contrast medium-induced kidney injury in patients with relatively normal renal function. However, whether contrast media cause additional deterioration of renal function in patients with acute kidney injury (AKI), including those with sepsis-associated AKI, remains unclear. This study aimed to evaluate the effect of contrast media on renal function and mortality in patients with sepsis who already had AKI. We performed a propensity score-matched historical cohort study in the medico-surgical intensive care unit of Jichi Medical University Hospital. Adult patients who were diagnosed with sepsis and AKI were enrolled. Records from our sepsis database from 2011 to 2017 were examined. Septic patients with AKI who received contrast media within 24 h of admission (C group) were matched 1:1 with septic patients who did not receive contrast media (NC group). The primary outcome was deterioration of kidney function (DRF), which was defined as an elevation of
T1 mapping of the myocardium: intra-individual assessment of post-contrast T1 time evolution and extracellular volume fraction at 3T for Gd-DTPA and Gd-BOPTA : Purpose Myocardial T1 relaxation time (T1 time) and extracellular volume fraction (ECV) are altered in patients with diffuse myocardial fibrosis. The purpose of this study was to perform an intra-individual assessment of normal T1 time and ECV for two different contrast agents. Methods A modified Look-Locker Inversion Recovery (MOLLI) sequence was acquired at 3 T in 24 healthy subjects (8 men; 28
The global Microbubbles/Ultrasound Contrast Agents Market will grow at a CAGR of 25.2% from 2018 to 2024 to reach USD 1,584.5 million by 2024, according to the latest publication from Meticulous Research®. The global microbubbles/ultrasound contrast agents market is driven by various factors such as advancement in...
is able to provide quantitative data regarding the anatomical and physiological features of each specific organ. Magnetic resonance imaging is a non-invasive method, but contrast agents are necessary to enhance the visualization of inaccessible organs in some organs such as gastrointestinal [GI] imaging. Various types of contrast agents have been used in studies including intravascular administration and oral materials. Oral contrast agents can be the artificial materials or natural factors. Natural contrast agents consist of fruit juice or pulps. Some advantages have been reported regarding the natural types of contrast agents over the artificial agents including better taste and tolerability. We briefly reviewed the different types of contrast agents and focused on the studies in which natural oral contrast agents used to investigate their efficacy in increasing the gastrointestinal magnetic resonance imaging clarity ...
TY - JOUR. T1 - Gastric cancer with synchronous and metachronous hepatic metastasis predicted by enhancement pattern on multiphasic contrast-enhanced CT. AU - Tsurumaru, Daisuke. AU - Nishimuta, Yusuke. AU - Muraki, Toshio. AU - Asayama, Yoshiki. AU - Nishie, Akihiro. AU - Oki, Eiji. AU - Honda, Hiroshi. PY - 2018/11. Y1 - 2018/11. N2 - Objective: The purpose of this study was to examine the relationship between the CT features of the primary-site gastric cancer and the concurrent existence or postoperative recurrence of hepatic metastasis. Materials and methods: From January 2013 to July 2016, 125 patients with advanced gastric cancer who were evaluated by gastroscopy and contrast-enhanced CT at our institution were included. Eleven patients had hepatic metastasis at the time of diagnosis (synchronous hepatic metastasis). Five patients had hepatic recurrence after surgery (metachronous hepatic metastasis, median follow-up period of 313 days), and another 56 patients had no hepatic recurrence ...
Ultrasound contrast agents (UCAs) have been in the echocardiographic toolbox for many years. Two such agents (Definity [Lantheus Medical Imaging, North Billerica, Massachusetts] and Optison [GE Healthcare, Princeton, New Jersey]) are approved by the U.S. Food and Drug Administration (FDA) and are commercially available for left ventricular cavity opacification in patients with technically difficult echocardiograms. The greater, still unrealized value of these unique erythrocyte tracers, however, resides in their ability to depict the spatial distribution of myocardial perfusion and to quantify intramyocardial blood volume, properties that render UCAs ideal for the detection and localization of coronary artery disease (CAD).. UCAs have had a checkered history, particularly with respect to myocardial perfusion imaging. The literature is replete with studies showing the promise of myocardial contrast echocardiography (MCE) for CAD detection (1,2). Studies in dogs dating back to the early 1980s ...
Magnetic Resonance Angiography (MRA) of the peripheral arteries has become essential in the diagnosis and follow-up of peripheral arterial disease.. In clinical routine, the acquisition uses intravenous injection of a Gadolinium based contrast agent (gadolinium chelates).. Initially, contrast enhanced MR angiography (CE-MRA) was recommended for diabetic patients, elderly patients and\or patients with chronic renal insufficiency presenting a contraindication to CT angiography using iodized contrast agent injection.. However, the increase in nephrogenic systematic fibrosis clinical cases, which would be secondary to gadolinium chelates injection, in patients with chronic renal insufficiency has restricted the use of CE-MRA. More than 500 cases were described to date in the world.. Its occurrence is currently estimated around 4 % for patients in terminal chronic renal insufficiency and its mortality around 30 %.. According to the recommendations of AFSSAPS from August, 2007, two gadolinium contrast ...
Abstract: Objective To compare the ultrasound features of papillary thyroid carcinoma with or without cervical lymph node metastasis (LNM). Methods Patients suspected of thyroid cancer underwent the conventional ultrasound and contrast-enhanced ultrasound (CEUS) examinations. Patients age,sex,and ultrasound characteristics of lesions were recorded. With the surgical pathology as the golden standard,the ultrasound features were compared between the cervical LNM group and non-LNM group. Results Of 144 patients,51 had cervical LNM and 93 did not. Patients ages,sex and number of lesions had no significant difference between two groups (all P>0.05). Tumor with LNM had maximum size greater than 0.85 cm,ill-defined margin (P=0.000),irregular shape (P=0.007),internal heterogeneous echogenicity (P=0.007),microcalcification (P=0.020),internal heterogeneous low-enhancement (P=0.002),peripheral non-enhancement ring (P=0.030),and extracapsular extension (P=0.000). Conclusion Conventional ultrasound and ...
Dr. Songping Huang: Synthesis of Nanoparticle-Based MRI/CT Contrast Agents and Gallium-Based Anticancer Drugs Chemistry & Biochemistry | The current research interests of Huang Group include development of nanoparticle-based contrast agents and molecular probes for in vivo imaging using MRI, CT and PET modalities and synthesis of novel biocompatible inorganic nanomaterials as
Patients receiving dialysis are also at theoretical risk from the osmotic load imposed by intravascular iodinated contrast medium because they cannot clear the excess intravascular volume. This osmotic load can theoretically result in pulmonary edema and anasarca. To mitigate this possible risk, contrast medium dosing should be as low as necessary to achieve a diagnostic result (as in all patients). However, complications were not observed in a study of dialysis patients who received intravascular nonionic iodinated contrast medium, though the number of patients was small. ...
Background: Coronary angiography is associated with a 4-15% chance of contrast-induced nephropathy (CIN). While the cause of CIN is still not understood, renal ischemia and free radical effects on tubular epithelial cells are thought to be responsible. In addition to increased hydration, the antioxidant properties of sodium bicarbonate are thought to decrease the direct toxic effects seen in CIN. The question of this treatments efficacy has been asked since its inception, and no definitive conclusion has been reached. The purpose of this systematic review is to compare and contrast the most current randomized trials, assessing the quality of the studies involved, and to give a practicing clinician a more complete understanding of the outcomes. Methods: Exhaustive search of available medical literature from 2006 to the present for randomized control trials regarding contrast-induced nephropathy in patients undergoing non-emergent coronary angiography. The reviewed studies examined the significance of
Compared to commercially available contrast agents under the same experimental conditions, these new cationic agents are three times more sensitive for imaging cartilage, said Mark W. Grinstaff, Boston University Professor of Chemistry and Biomedical Engineering who led the team with Brian D. Snyder, MD, Ph.D. an orthopedic surgeon at Childrens Hospital and Harvard Medical School. Snyder noted that the ability to acquire information about localized GAG content, morphology and cartilage thickness on tissue samples will, in the future, aid in the diagnosis and treatment of osteoarthritis. And while the data presented a compelling case for continued development of cationic CT contrast agents, the research team cautioned that the suitability for in vivo applications remains to be determined, adding that toxicity levels and radiation dosage will be the focus of future studies. However, the ability to characterize ex vivo cartilage samples is clearly evident, the study concludes. Currently ...
Todays pearl reviews some of the literature and recommendations regarding the use of iodinated contrast in patients with kidney disease Will it cause an acute-on-chronic injury? Is it safe? Its long been debated what role, if any, iodinated contrast agents play in causing acute kidney injury (AKI). In the largest ED study to date, there…
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Targeted contrast-enhanced ultrasound (TCEUS) is an innovative method of molecular imaging used for detection of inflammatory biomarkers in vivo. By targeting ultrasound contrast to cell adhesion molecules (CAMs), which are known inflammatory markers within neural tissue, a more direct evaluation of neural inflammation can be made. Due to the novel nature of TCEUS, standardized methods of image analysis do not yet exist. Time intensity curve (TIC) shape analysis is currently used in magnetic resonance contrast imaging to determine temporal behavior of perfusion.
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Magnetic resonance imaging (MRI) is a noninvasive medical imaging modality that is routinely used in clinics, providing anatomical information with micron resolution, soft tissue contrast, and deep penetration. Exogenous contrast agents increase image contrast by shortening longitudinal (|i|T|/i||sub|1|/sub|) and transversal (|i|T|/i||sub|2|/sub|) relaxation times. Most of the |i|T|/i||sub|1|/sub| agents used in clinical MRI are based on paramagnetic lanthanide complexes (largely Gd-based). In moving to translatable formats of reduced toxicity, greater chemical stability, longer circulation times, higher contrast, more controlled functionalisation and additional imaging modalities, considerable effort has been applied to the development of nanoparticles bearing paramagnetic ions. This review summarises the most relevant examples in the synthesis and biomedical applications of paramagnetic nanoparticles as contrast agents for MRI and multimodal imaging. It includes the most recent developments in the
Objectives The purpose of this study was to compare sulfur hexafluoride microbubble (SonoVue)-enhanced myocardial contrast echocardiography (MCE) with single-photon emission computed tomography (SPECT) relative to coronary angiography (CA) for assessment of coronary artery disease (CAD). Background Small-scale studies have shown that myocardial perfusion assessed by SonoVue-enhanced MCE is a viable alternative to SPECT for CAD assessment. However, large multicenter studies are lacking. Methods Patients referred for myocardial ischemia testing at 34 centers underwent rest/vasodilator SonoVue-enhanced flash-replenishment MCE, standard Tc-99m-labeled electrocardiography-gated SPECT, and quantitative CA within 1 month. Myocardial ischemia assessments by 3 independent, blinded readers for MCE and 3 readers for SPECT were collapsed into 1 diagnosis per patient per technique and were compared to CA (reference standard) read by 1 independent blinded reader. Results Of 628 enrolled patients who received ...
OBJECTIVE: For minimal invasive treatment of small renal masses, cryoablation has gained popularity. Treatment success is defined as absence of contrast enhancement on postoperative imaging of the cryoablated lesion, but contrast enhancement does not necessary equal treatment failure. This present study investigates the proportion of spontaneous resolutions after initial contrast enhancement in relation to cryoablation.. PATIENTS AND METHODS: Data were collected from a prospectively maintained clinical database containing all patients treated with primary laparoscopic and percutaneous cryoablation between August 2005 and December 2013. All images were evaluated with regard to PADUA-score, cryolesion size, contrast enhancement pattern and tissue density.. RESULTS: A total of 107 patients with a biopsy verified malignant tumor were included in the study. On postoperative imaging 33 (31%) patients presented with contrast enhancement. Spontaneous resolution was observed in 15 (45%) patients after a ...
PubMed journal article The impact of iodinated contrast agent administered during preoperative computed tomography scan on body iodine pool in patients with differentiated thyroid cancer preparing for radioactive iodine treatmen were found in PRIME PubMed. Download Prime PubMed App to iPhone, iPad, or Android
We read with great interest the article by Arevalo-Perez et al, describing the potential value of T1-weighted dynamic contrast-enhanced MR imaging (DCE-MR imaging) as a biomarker for epidermal growth factor receptor variant III (EGFRvIII) mutation in patients with glioblastoma (GBM).
Computed tomography (CT) scans are an imaging method that use x-rays to create pictures of cross-sections of the body. Many CT scans involve intravenously injected iodinated contrast agents - but they have drawbacks such as fast clearance and side effects. Due to these limitations, nano-sized iodinated CT contrast agents have been developed that can increase the circulation time and decrease the adverse effects. In addition to iodine, nanoparticles based on heavy atoms such as gold, lanthanides, and tantalum are used as more efficient CT contrast agents.
As gadolinium contrast dye lawsuits mount, a new study warns that children can experience allergic like reactions from side effects of MRI contrast agents.
P3T PA (pulmonary angiography), from Medrad, is a personalized contrast-dosing software that increases the percentage of diagnostic-quality CT pulmonary angiography (CTPA) studies to rule out pulmonary embolism (PE).. Researchers have concluded that suboptimal CTPA interpretations to rule out PE can substantially impact healthcare resource utilization and increase healthcare costs. With 30 percent of their CTPA studies showing suboptimal results, these patients were subjected to additional imaging studies and/or received medical therapy. Some patients were admitted to the hospital for further PE diagnosis considerations. None of the additional treatments or imaging modalities yielded a diagnosis of PE.. P3T PA fits into the established workflow and offers flexibility and efficiency in optimizing each patients contrast dose -- especially when operating higher-speed scanners. The P3T algorithm tailors each patients contrast protocol based on technologists touch-screen responses to unique ...
Of the 3 parameters studied, Vp was the most significant measure of tumor response. Differences in Vp mean and Vp maximum values pre- and posttreatment were significant. On average, Vp max values were approximately 1.6 times greater before treatment, which is concordant with previous work demonstrating the significantly higher vascularization of chordoma in comparison with that of adjacent normal tissues.17 Chordoma has been shown to express elevated vascular endothelial growth factor and matrix metalloproteinase-9, which may work in concert to increase angiogenesis and invasiveness and promote recurrence of chordoma and other bone cancers.18⇓-20. Ktrans was also a positive indicator of tumor response to therapy. A measure of vascular permeability, Ktrans represents the rate at which blood is transferred from the vascular compartment to the extravascular extracellular space. Therefore, unlike Vp, Ktrans is a marker of tumor leakiness rather than actual tumor vascularity. On receiving RT, ...
An 80 year old man with a history of abdominal aortic aneurysm, repaired 10 years previously, presented to the emergency room with a four hour history of severe epigastric pain. Examination demonstrated a distended, tender, but non-rigid abdomen. ECG was unremarkable. Shortly after arrival the patient suffered a sudden onset of massive haematemesis requiring replacement of large volumes of intravenous colloid and blood. Following successful resuscitation urgent endoscopy was undertaken, but failed to demonstrate a bleeding point because of large amounts of fresh blood in the stomach. Abdominal multidetector computed tomography (CT) (Siemens Forchheim, Somatom plus 4) was then performed. Axial images of the abdomen (panel A), at a level just inferior to the renal arteries, showed intravenous contrast medium in a slightly aneurysmal abdominal aorta (black solid arrow). Intravenous contrast medium is also seen outlining the inner wall of the third part of the duodenum (white arrow). An aortoenteric ...
Barium sulfate, used as a radio-opaque marker in some orthopedic bone cements, has been shown to escape into the surrounding tissues. This may present a potential hazard. In particular, phagocytic cells may be exposed to relatively high internal levels of barium once the particles have been phagocytosed. Mouse peritoneal macrophages exposed to barium sulfate for periods up to 144 hr showed a marked cytoplasmic vacuolization from which they recovered only partially. Barium sulfate did not appear to damage the cell membrane as judged by lactice dehydrogenase release. In the relatively low doses and with the periods of exposure described here, barium sulfate does not appear to present a serious toxic hazard in the short term. It is possible, however, that longer exposures and larger doses may result in the death of phagocytic cells which have ingested barium sulfate. ...