PURPOSE:. To investigate the possibility of detecting cardiac transplant rejection and determining its degree of severity with magnetic resonance (MR) imaging with a blood pool contrast agent.. MATERIALS AND METHODS:. Rat allogeneic (PVG to Wistar/Kyoto, n = 9) and syngeneic (Wistar/Kyoto to Wistar/Kyoto, n = 6) heterotopic heart transplantations were performed. On the 2nd and 6th postoperative days, an ultrasmall superparamagnetic iron oxide, or USPIO, contrast agent was injected intravenously at a dose of 2 mg of iron per kilogram of body weight. The injection was followed by three-dimensional T1-weighted MR imaging of the heart grafts with an imaging time of approximately 2 minutes for each image for 44 minutes. The signal intensity (SI) was measured in the myocardium over time, and the relative enhancement was calculated. After the 6th day, the rats were sacrificed, and the morphology of the transplanted hearts was assessed histologically. The CIs for the difference of the means on day 2 and ...
TY - JOUR. T1 - Liver perfusion changes occurring during pancreatic islet engraftment. T2 - A dynamic contrast-enhanced magnetic resonance study. AU - Esposito, A.. AU - Palmisano, A.. AU - Maffi, P.. AU - Malosio, M. L.. AU - Nano, R.. AU - Canu, T.. AU - De Cobelli, F.. AU - Piemonti, L.. AU - Ironi, G.. AU - Secchi, A.. AU - Del Maschio, A.. PY - 2014/1. Y1 - 2014/1. N2 - The aim of this study was to investigate liver microvascular adaptation following the intraportal infusion of pancreatic islets (pancreatic islet transplantation [islet-tx]) in diabetic patients using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). DCE-MRI was performed before and 7 days after islet-tx in six diabetic patients. Initial area under curve (AUC60) and volume transfer coefficient (Ktrans) were assessed as markers of liver perfusion. Clinical and metabolic monthly follow-up was performed in all patients, considering fasting C-peptide and β-score as main indices of graft function. High variability ...
This study intends to assess the ability of contrast-enhanced ultrasound in the detection of benign and malignant ovarian masses compared to unenhanced ultrasound.. By using an intravascular contrast agent, this noninvasive and feasible imaging technique will allow the investigators to define specific microcirculation patterns in 100 women with ovarian lesions.. The intravascular contrast agent properties will be compared between benign and malignant adnexal masses.. The final purpose of this ultrasonography is to allow the early detection of tumors and to improve the characterization between benign and malignant lesions. ...
TY - GEN. T1 - Segmentation and classification of breast tumor using dynamic contrast-enhanced MR images. AU - Zheng, Yuanjie. AU - Baloch, Sajjad. AU - Englander, Sarah. AU - Schnall, Mitchell D.. AU - Shen, Dinggang. PY - 2007/12/1. Y1 - 2007/12/1. N2 - Accuracy of automatic cancer diagnosis is largely determined by two factors, namely, the precision of tumor segmentation, and the suitability of extracted features for discrimination between malignancy and benignancy. In this paper, we propose a new framework for accurate characterization of tumors in contrast enhanced MR images. First, a new graph cut based segmentation algorithm is developed for refining coarse manual segmentation, which allows precise identification of tumor regions. Second, by considering serial contrast-enhanced images as a single spatio-temporal image, a spatio-temporal model of segmented tumor is constructed to extract Spatio-Temporal Enhancement Patterns (STEPs). STEPs are designed to capture not only dynamic ...
Summary:Intravenous contrast media, specifically the gadolinium chelates, are well accepted for use in the clinical practice of magnetic resonance imaging. The gadolinium chelates are considered to be very safe and lack (in intravenous use) the nephrotoxicity found with iodinated contrast media. Min
North America, Europe, Asia-Pacific, and Rest of the World (RoW) are the regions considered for a geographic analysis of the global contrast media/contrast agents market. North American contrast media/contrast agents market is expected to account for the largest share of the global contrast media/contrast agents market. However, the Asia Pacific contrast media/contrast agents market is expected to grow at the highest CAGR in the forecast period. This growth can be attributed to the increasing R&D investments and favorable demographic scenario in China, rising aging population and cancer incidence in Japan, growing investments in the Indian radiology market, and growing focus of market players & increasing government support in other APAC countries.. The prominent players in the global contrast media/contrast agents market include GE Healthcare (US), Bracco Imaging S.p.A. (Bracco) (Italy), Bayer HealthCare (Bayer) (Germany), and Guerbet Group (Guerbet) (France).. Don t miss out on business ...
Antivascular treatments can either be antiangiogenic or targeting established tumour vasculature. These treatments affect the tumour microvasculature and microenvironment but may not change clinical measures like tumour volume and growth. In research on antivascular treatments, information on the tumour vasculature is therefore essential. Preclinical research is often used for optimization of antivascular drugs alone or in combined treatments. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is an in vivo imaging method providing vascular information, which has become an important tool in both preclinical and clinical research. This review discusses common DCE-MRI imaging protocols and analysis methods and provides an overview of preclinical research on antivascular treatments utilizing DCE-MRI.
Currently there are no approved biomarkers for the pre-symptomatic diagnosis of Alzheimers disease (AD). Cathepsin-D (Cat-D) is a lysosomal protease that is present at elevated levels in amyloid plaques and neurons in patients with AD and is also elevated in some cancers. We have developed a magnetic resonance imaging (MRI)/fluorescent contrast agent to detect Cat-D enzymatic activity. The purpose of this study was to investigate the cellular and tissue uptake of this MRI/fluorescent contrast agent. The agent consists of an MRI probe [DOTA-caged metal ion (Gd3+ or Tm3+)] and a fluorescent probe coupled to a cell-penetrating-peptide sequence by a Cat-D recognition site. The relaxivity of Gd3+-DOTA-CAT(cleaved) was measured in 10% heat-treated bovine serum albumin (BSA) phantoms to assess contrast efficacy at magnetic fields ranging from 0.24 mT to 9.4 T. In vitro, Tm3+-DOTA-CAT was added to neuronal SN56 cells over-expressing Cat-D and live-cell confocal microscropy was performed at 30 min. ...
Heterogeneity is a common finding within tumours. We evaluated the imaging features of tumours based on the decomposition of tumoural dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data to identify their prognostic value for breast cancer survival and to explore their biological importance. Imaging features (n = 14), such as texture, histogram distribution and morphological features, were extracted to determine their associations with recurrence-free survival (RFS) in patients in the training cohort (n = 61) from The Cancer Imaging Archive (TCIA). The prognostic value of the features was evaluated in an independent dataset of 173 patients (i.e. the reproducibility cohort) from the TCIA I-SPY 1 TRIAL dataset. Radiogenomic analysis was performed in an additional cohort, the radiogenomic cohort (n = 87), using DCE-MRI from TCGA-BRCA and corresponding gene expression data from The Cancer Genome Atlas (TCGA). The MRI tumour area was decomposed by convex analysis of mixtures (CAM), resulting
TY - JOUR. T1 - Glomerular filtration rate estimated after multiple injections of contrast medium during angiography. AU - Boijsen, M.. AU - Granerus, G.. AU - Jacobsson, L.. AU - Björneld, L.. AU - Aurell, M.. AU - Tylen, Ulf. PY - 1988. Y1 - 1988. N2 - In twenty-six patients referred for angiography, clearance of contrast medium was determined with x-ray fluorescence analysis after multiple injections of contrast medium. A formula for correction of the injected amount, which takes into consideration the different times of contrast medium injections, approximating the total injected amount into one injection, was used. A single injection clearance of 51Cr-EDTA was determined at the same time. the results showed a good correlation between the clearance of contrast medium after multiple injections and the 51Cr-EDTA clearance after a single injection (r=0.945). the correlation between contrast medium clearance calculated without correction for the different injection times, and 51Cr-EDTA ...
Abstract: Significant progress has been made in recent years in the development of effective ultrasonic contrast agents for inducing better image contrast of certain anatomic structures in the body for diagnostic purposes. An ideal ultrasonic contrast agent should have the following characteristics: (1) be nontoxic, (2) be capable of producing sufficient contrast via intravenous injection, and (3) have a long persistence time. Gaseous contrast agents such as Albunex[sup (registered)] (Molecular Biosystems), Echovist[sup (registered)] and Levovist[sup (registered)] (Schering), and EchoGen[sup (registered)] (Sonus) have been shown to satisfy a majority of these requirements. Albunex[sup (registered)] was approved in 1994 by the FDA for clinical use. The most intriguing application of these contrast agents is in harmonic pulse-echo and Doppler imaging since nonlinear resonance of microairbubbles would yield echoes at the harmonics of the incident frequency. If detection is made at one of these ...
Dynamic Contrast-Enhanced Magnetic Resonance Imaging As a Biomarker for the Pharmacological Response of PTK787/ZK 222584, an Inhibitor of the Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, in Patients With Advanced Colorectal Cancer and Liver Metastases: Results From Two Phase I ...
Acute adverse reactions to contrast media will occur at a certain rate. Non-ionic iodinated contrast is said to have an adverse reaction rate of about 0.6 to 3.1% [6-10]. This rate is said to be about 0.07 to 0.67% for gadolinium contrast media [6-9].. The ACR Manual on Contrast Media [1] and EUSR Guidelines on Contrast Media [2] recommend premedication for patients at risk for adverse reactions to contrast, but the definition of at-risk has some variation among protocols and studies. The ACR Manual states patients with a history of adverse reactions should be premedicated, but does not elaborate on the degree of the reaction. The ESUR Guidelines, on the other hand, includes patients with a history of moderate or severe reactions. When following the ESUR Guidelines, patients with history of mild reactions to contrast undergo contrast enhanced examinations without premedication. (We chose to follow and reference the older versions of the ACR Manual and ESUR Guidelines, as these were the ones ...
The Global Contrast Media Market is going to continue with the same trends of growth during the forecast period. The major factors influencing the growth of the market include increasing technology advancement in contrast medium, increasing prevalence of cancer and cardiac diseases, growth in emerging markets for imaging technology, increasing demand for diagnostics, and image guide procedures and various others. Whereas, the risk of side effects and adverse effects of the contrast media may hamper the growth of the market. Exclusive Sample Copy @https://www.marketresearchfuture.com/sample_request/1284 .. Contrast media are substances which are utilized to improve the contrast of fluids in the body during medical imaging. It is basically used to enhance the visibility of blood vessels and GI tract. The global contrast media market is growing with the steady pace; mainly due to the increasing prevalence of different diseases such as GIT diseases and cardiac diseases. According to a recent study ...
Dynamic contrast-enhanced (DCE)-MRI is useful to assess the early effects of drugs acting on tumor vasculature, namely anti-angiogenic and vascular disrupting agents. Ultra-high-field MRI allows higher-resolution scanning for DCE-MRI while maintaining an adequate signal-to-noise ratio. However, increases in susceptibility effects, combined with decreases in longitudinal relaxivity of gadolinium-based contrast agents (GdCAs), make DCE-MRI more challenging at high field. The aim of this work was to explore the feasibility of using DCE-MRI at 11.7 T to assess the tumor hemodynamics of mice. Three GdCAs possessing different molecular weights (gadoterate: 560 Da, 0.29 mmol Gd/kg; p846: 3.5 kDa, 0.10 mmol Gd/kg; and p792: 6.47 kDa, 0.15 mmol Gd/kg) were compared to see the influence of the molecular weight in the highlight of the biologic effects induced by combretastatin A4 (CA4). Mice bearing transplantable liver tumor (TLT) hepatocarcinoma were divided into two groups (n = 5-6 per group and per ...
Envision uses non-ionic contrast media. This is the safest intravenous contrast media available.. Sometimes an injection of contrast media is indicated to enhance diagnostic accuracy of the examination and enhance the quality. Following an injection of contrast media, you may experience a sensation of heat, an unusual taste or smell and a tingling sensation in the pelvic area. These symptoms are common and very transient. The contrast is eliminated from the body by the kidneys and is excreted in the urine within hours of the initial injection. Patients are encouraged to drink additional clear fluids following their examination to assist in the filtration of the kidneys.. Occasionally, patients can experience minor allergic reactions such as hives. In rare cases, a major allergic reaction can occur. Envision staff are trained in the management of allergic reactions and all sites that administer intravenous contrast media are equipped with emergency medications and equipment, should a patient ...
Although effective in promoting the prevention of SCD, current risk stratification strategies in HCM patients do not identify all at-risk patients, largely as a result of the substantial heterogeneity in clinical and phenotypic expression of this genetic disease.2,3,5,8,42 Because SCD can occur in HCM patients considered to be at low risk, identification of additional markers to allow more precise selection of those patients who may benefit from primary prevention ICD therapy represents a major clinical aspiration.3,28 Recently, considerable interest in using contrast-enhanced CMR to improve the risk stratification model has emerged.43-48 However, available data on the prognostic value of CMR do not provide an opportunity to specifically predict SCD risk for individual HCM patients.28,29 In the present large, multicenter HCM cohort, we have investigated LGE as a predictor of SCD and other adverse disease consequences among a predominantly lower-risk cohort of HCM patients.. Our data show that in ...
Contrast Media Injectors (Diagnostic Imaging) - Global Market Analysis and Forecast Model has complete details about market of Contrast Media Injectors (Diagnostic Imaging) industry, Contrast Media Injectors (Diagnostic Imaging) analysis and current trends. Contrast Media Injectors (Diagnostic Imaging) - Global Market Analysis and Forecast Model Summary Contrast Media Injectors (Diagnostic Imaging) - Global Market Analysis and Forecast Model is built to visualize quantitative market trends within Diagnostic Imaging therapeutic area. Contrast Media Injectors are devices used to inject contrast medi.
Early buyers will receive 10% customization on reports.. This report studies the global contrast media/contrast agentsmarket for the forecast period of 2016 to 2021. This market is expected to reach a value of USD 5.44 Billion by 2021, from an estimated value of USD 4.46 Billion in 2016, at a CAGR of 4.1%.. The prominent players in the global contrast media/contrast agents market include Bayer HealthCare (Germany), GE Healthcare (U.S.), Guerbet Group (France), and Bracco Imaging S.p.A. (Italy). These companies hold a dominant position in the contrast media/contrast agents market mainly due to their well-established presence in the field of genomics, presence in over 50 countries, high R&D investments, and strong sales and distribution force. Other players operating in this market include Lantheus Medical Imaging (U.S.), nanoPET Pharma GmbH (Germany), CMC Contrast AB (Sweden), Daiichi Sankyo (Japan), and Subhra Pharma Private Limited (India).. The global contrast media/contrast agentsmarket has ...
Many CT studies require intravenous contrast agent. This is a special fluid containing iodine that enhances the blood vessels and certain organs and allows them to be better visualised, highlighting any abnormalities. If your examination requires an intravenous contrast injection, you will be asked whether you have a history of allergies or asthma; and whether you are on diabetic medication. Oral contrast media are not usually required for CT studies of the brain and spine. ...
TY - JOUR. T1 - Effects of contrast media on renal function and subcellular morphology in the dog. AU - Katzberg, Richard W. AU - Pabico, Rufino C.. AU - Morris, Thomas W.. AU - Hayakawa, Katsumi. AU - McKenna, Barbara A.. AU - Panner, Bernard J.. AU - Ventur, Janine A.. AU - Fischer, Harry W.. PY - 1986. Y1 - 1986. N2 - The effects of intravenous contrast media (CM) on renal excretory function and subcellular morphology are examined in this animal investigation. A decrease in GFR (12.0 ±1.6 vs. control 30.2 ± 2.S ml/min) was observed when renal function was evaluated by means of the artero-venous extraction method with Tc99m DTP A and the anticipated inverse relationship to urinary flow (Vml/min) noted. An artifactual increase in GFR (43.S ± 10.0 vs. control 39.1 ± 3.8 ml/min) was observed using the timed urinary clearance of inulin. V(ml/min) increased four-fold (0.6 ± 0.16 control vs. 2.7 ± 0.7 ml/min; P ,.05) over the first five minutes after injection of CM. Urine osmolality initially ...
OBJECTIVES The aim of this study was to investigate the feasibility of using contrast-enhanced ultrasound (CEUS) in experimental breast cancer bone metastases and its utilization for assessment of early antiangiogenic treatment response in these lesions. MATERIALS AND METHODS Nude rats bearing bone metastases (n = 20) were treated with the antiangiogenic tyrosine kinase inhibitor sunitinib daily from days 30 to 35 after MDA-MB-231 tumor cell inoculation (n = 10) and compared with sham-treated controls (n = 10). Imaging with ultrasound (US) and magnetic resonance imaging (MRI) was performed on days 30, 32, and 35 after tumor cell inoculation to determine tumor volume and parameters of vascularization in bone metastases. Contrast-enhanced US images were used to calculate wash-in and wash-out values, peak enhancement, and area under the curve from time intensity curves. In addition, a quantitative analysis software was used to determine regional blood volume and flow as well as filling times within bone
ECCO - European Crohn´s and Colitis Organisation. The European Crohn\s and Colitis Organisation is a highly active non-profit association focusing on Inflammatory Bowel Diseases (IBD).
CMR adenosine first pass perfusion yields excellent results for the detection of significant coronary artery disease. As in patients after coronary artery bypass grafts (CABG) myocardial perfusion is more complex and additionally the kinetic of a first pass bolus may by altered due to different distances through the bypasses and/or native vessels, this patient group has been excluded from most published studies. Parameters like speed of contrast wash-in (upslope, time to 50% or peak enhancement) and peak enhancement are indirectly used for visual analysis and may be altered post CABG imitating perfusion defects without significant stenosis. In this case, adenosine perfusion would be an inadequate diagnostic test. ...
Microparticles which are less than 12 μm in size and are formed of or comprise a solid lipophilic group-containing compound having an HLB value less than about 20 produce a long lived ultrasonically echogenic entity in aqueous liquid and are useful as left heart ultrasonic contrast image enhancing agents. Contrast media for ultrasonic diagnostics comprising a liquid vehicle containing (a) suspended therein microparticles of a mixture of at least one (C8 -C20)-fatty acid and at least one solid that is not a surfactant and (b) microbubbles, are especially effective upon ultrasonic imaging after intravenous administration, for the contrasting of both the right heart and left heart, of the myocardium, as well as other organs, such as liver, spleen, and kidneys.
Absolute cerebral perfusion parameters were obtained by dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) carried out using different contrast-agent administration protocols. Sixteen healthy volunteers underwent three separate DSC-
Contrast-enhanced magnetic resonance angiography (MRA) employs the use of blood pool contrast agents (CA) such as gadolinium (Gd3+) complexes that allow for delayed phase arterial
Image acquisition strategies. Principal contrast mechanisms in MRI emerge from the relaxation properties of tissue water (or fat) hydrogen nuclei in the scanner magnetic field after undergoing radiofrequency excitation. These properties can be manipulated to reflect features of the molecular and physiologic environment of a tissue. T1-weighted images emphasize the rate (different for different tissue types) at which energy is redistributed between these nuclei and the tissue as a whole. T2*-weighted images emphasize the different rates at which the same nuclei lose phase coherence with one another and the way that this process is affected by local variations in field strength due to differences in magnetic susceptibility between tissues. Conventional gadolinium chelate-based contrast media affect T1-weighted images causing a signal increase, and T2*-weighted images causing a signal decrease.. Nearly all clinical DCE-MRI is done at 1.5 T. The data have a typical spatial resolution of a few ...
Dynamic Contrast-Enhanced Magnetic is now established as the methodology of choice for the assessment of tumor microcirculation in vivo. The method assists
We describe here in a large group of patients qualitative and semiquantitative DCE-MRI parameters that distinguish sMM from normal controls. We also provide evidence that this technique can identify a distinct patient population in NRC that presents with a pathologic DCE-MRI. Referring to this, pathologic findings according to our analysis were defined by a pattern of strongly increased microcirculation (diffuse variant), focal hotspots in the investigated area (focal pattern), or by an amplitude A above the upper limit of normal controls. It has to be mentioned that a diffuse variant pattern cannot be distinguished from a focal pattern affecting the whole vertebra, which may explain in part why those two patterns seem to seem exclusively in the same, namely the symptomatic patient group.. Different patterns of bone marrow involvement of MM in conventional as well as DCE-MRI have been described concordantly by different authors (14, 23, 29, 30). Diffuse distribution of microcirculation was found ...
We read with great interest the article by Jablonowski et al. (1) showing that contrast-enhanced cardiac magnetic resonance (ce-CMR) overestimates infarct size at 6 h post-reperfusion compared with pathology and that infarct imaging timing by ce-CMR is critical. Although this is not an entirely new finding, the careful and meticulous work performed by the authors demonstrates the rapidly changing nature of acute infarction and reperfused myocardial tissue (2). If this experimental work focuses precisely on infarct sizing, the reader is left with several open questions.. On observation of the different figures from this article (Figures 3 and 6), there is a 50% reduction of infarct size by ce-CMR, whereas there is a 26% increase in myocardial salvage and a 30% reduction in extracellular volume by pathology in the infarcted myocardium and adjacent areas between day 0 and day 7. In this rapid series of myocardial tissue changes, it is hard for the reader to understand that the same changes do not ...
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A contrast medium injector for injecting a patient with contrast medium for a CT scan is programmed to provide an injection protocol that is a representation of an ideally defined exponential curve with an initial injection rate decaying at an exponential rate. This has been found to produce a uniform vascular enhancement for the scanning of a patients blood vessels. The particular exponential decay coefficient which has been found to be optimal is directly proportional to the cardiac output divided by the patients weight and is approximated at 0.01 for a typical human.
Purpose To evaluate the feasibility of ultrafast dynamic contrast-enhanced (UF-DCE) magnetic resonance imaging (MRI) with compressed sensing (CS) for the separate identification of breast arteries/veins and perform temporal evaluations of breast arteries and veins with a focus on the association with ipsilateral cancers. Materials and Methods Our Institutional Review Board approved this study with retrospective…
Following administration of Gadolinium there can be three possible enhancement kinetic curves for a lesion on breast MRI (these are also applied in other organs such as prostate MRI). These are sometimes termed the Kuhl enhancement curves. type ...
The invention relates to ultrasonic contrast agents composed of microparticles which contain a gas and polyamino-dicarboxylic acid-co-imide derivatives, to processes for their preparation and to their use as diagnostic and therapeutic agents.
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
This group comprises X-ray, MRI and Ultrasound contrast media. The X-ray contrast media are subdivided into iodinated and non-iodinated compounds, and are further classified according to water solubility, osmolarity and nephrotropic/hepatotropic properties. High osmolar substances correspond mainly to ionic substances, except from ioxaglic acid, which is classified together with the non-ionic substances. MRI contrast media are subdivided according to magnetic properties. ...
Introduction: Contrast-induced nephropathy (CIN) is an important adverse outcome of coronary angiography/intervention. The role of pre-procedural statins in preventing CIN is unclear. Furthermore, the relative efficacy of different statins is unknown. Accordingly, we sought to perform a network meta-analysis to address this question.. Methods: We performed a Bayesian network meta-analysis of randomized controlled trials that evaluated the impact of statin therapy prior to coronary angiography/intervention on post-procedure outcomes. The primary outcome was the incidence of CIN assessed as an increase in serum creatinine ,0.5 mg/dl or , 25% from baseline at 48-72 hours; need for hemodialysis (HD) at 30 days was the secondary outcome. Different types and doses of statins were pooled and compared with Bayesian random-effects models, calculating pooled odds ratios (OR) and associated 95% credible intervals (95% CrI) for the Bayesian analysis.. Results: A total of 14 studies (9 statin vs. placebo; 5 ...
In medicine, every detail counts - we make it visible.. Organs and tissues of the body are very difficult to differentiate from one another in radiological diagnostics. Differentiation is frequently only possible with the use of contrast media.. With contrast media injectors for use in computed tomography (CT), magnetic resonance imaging (MRI) and angiography, ulrich medical® offers a complete product portfolio.. Our contrast media injectors have already been successfully used for more than 30 years in radiology practices and hospitals. They offer users unique solutions which are only available from ulrich medical®. Their user-friendly handling, superior "Made in Germany" quality and proven hygiene safety make these products indispensable in everyday practice.. ...
MarketResearchReports.Biz announces addition of new reportBRIC Contrast Media Injectors Market Outlook to 2020to its database BRIC Contrast Media Injectors Market Outlook to 2020, provides key market data on the BRIC Contrast Media Injectors market. The report provides value, in millions of US dollars, and volume (in units) and average price data (in US dollars), within market categories CT Injectors, Interventional Cardiology/Angio Injectors and MRI Injectors. View Full Report at http://www.marketresearchreports.biz/analysis/195610 The report also provides company shares and distribution shares data for each of these market categories, and global corporatelevel profiles of the key market participants, pipeline ...
Eighteen subjects, including 9 with significant coronary artery disease (CAD) and 9 healthy volunteers prospectively underwent perfusion CMR imaging using a saturation recovery gradient echo sequence acquired at basal, mid and apical left ventricular short-axis levels during adenosine vasodilator stress and at rest, using 0.05 mmol/kg gadolinium-DTPA. Comparison was made between MBF quantified using: 1. Calculated contrast agent concentration curves (to correct for signal saturation) versus raw signal intensity curves; 2. Mid-ventricular versus basal-ventricular short-axis arterial input function (AIF) extraction; 3. Three different deconvolution approaches; Fermi function parameterization, truncated singular value decomposition (TSVD) and first-order Tikhonov regularization with a b-spline representation of the impulse response function. CAD patients also prospectively underwent rubidium-82 positron emission tomography (PET; median interval 7 days) and MBF measurements made using PET and CMR ...
Perfusion data characterize the regional blood flow in human tissue. In the diagnosis of the Coronary Heart Disease, they are acquired to detect hypoperfused regions of the myocardium (heart muscle) at an early stage or to evaluate the hemodynamical relevance of a known pathologic vessel narrowing. For each voxel in the data, a time-intensity curve describes the enhancement of a contrast agent. Parameters derived from these curves characterize the regional perfusion and have to be integrated for diagnosis. The diagnostic evaluation of this multi-field data is challenging and time-consuming due to its complexity. We tackle this problem by developing a glyph-based integrated visualization of perfusion parameters in 3D-space with the patient-individual ventricular anatomy as context information. Besides the assessment of myocardial perfusion, current cardiac imaging technology allows for the investigation of myocardial contractility as well as for the detection of non-viable tissue. The combined ...
... This study covers the world outlook for contrast media injectors - Market research report and industry analysis - 12882381
Adverse reactions to contrast agents range from a mild inconvenience, such as itching associated with hives, to a life-threatening emergency. Renal toxicity is a well known adverse reaction associated with the use of intravenous contrast material. Other forms of adverse reactions include delayed allergic reactions, anaphylactic reactions, and local tissue damage. Previous allergic reactions to contrast material, asthma, and allergies are factors associated with an increased risk of developing an adverse reaction. Pretreatment of patients who have such risk factors with a corticosteroid and diphenhydramine decreases the chance of allergic reactions, including anaphylaxis, renal failure, or a possible life-threatening emergency. Awareness of the different types of risk factors and prescreening for their presence allows for early recognition and prompt treatment. Prophylactic treatment before administration of contrast material can prevent potential adverse reactions. If such reactions do occur, prompt
Nough, H., Eghbal, F., Soltani, M., et al. (2013) Incidence and main determinants of contrast-induced nephropathy following coronary angiography or subsequent balloon angioplasty. CardioRenal Medicine, 3, 128-135.
The report Global Contrast Media Market - Size, Outlook, Trends, and Forecasts (2018 - 2024) the Global Contrast Media Market expected to reach USD X Million by the year 2024, at a CAGR of 5.3% during forecast period. The contrast media market has onlooker various plans in products and their concurrence to meet the needs of patients and radiologists worldwide
Author: Su, W et al.; Genre: Poster; Published in Print: 2005-07; Title: Preparation, Characterization and Visualization of CPP-Mediated MR Contrast Agents
Growing its range of magnetic resonance imaging (MRI) contrast media options available to patients and radiologists, GE Healthcare today announced the
A new imaging technology may hold the key to not only stopping heart attacks in their tracks but also preventing them for ever occurring.
As part of a number of examinations, you may need to have an injection of Radiographic Contrast Medium. This is a colourless dye that shows up on x-ray pictures and scans, and is used to highlight structures in the body that cant be seen without it. This contrast agent causes no complication in the vast majority of people who have it.. There are risks involved with any medical procedure; and in a small number of people, certain side effects can occur following an injection of contrast agent.. Many people describe a feeling of warmth around their body and an unusual taste in the mouth. This is normal and lasts for a minute or two. Brief nausea may occur. Some people develop minor allergic symptoms such as hives, itchiness or a stuffy nose or eyes.. Your doctor (who requested this test) is aware of the risks, and has recommended the test knowing the benefits of the examination far outweigh the tiny risk involved.. ...
We tested the hypothesis that differences in proximal and distal contrast bolus arrival times may result in insufficient vascular signal in the distal part of the aortoiliofemoral territory with routinely used timing techniques. The difference in arrival time of the contrast medium bolus between the aorta and the common femoral arteries was measured in 14 patients undergoing magnetic resonance angiography of the aortoiliac arteries. A dual-station test bolus technique adjusting for this difference was evaluated. The variation coefficient of the signal intensity in six defined locations and signal intensities (SI) normalised to fat were calculated. Comparisons were made with findings in 13 patients examined with a fluoroscopically triggered timing technique (BolusTrak, Philips Medical Systems, Best, The Netherlands). The difference in bolus arrival time between proximal and distal vessels was 0-7 s. In 3 of 14 patients it was 5.6-7 s. There was a tendency towards a lower mean variation ...
Molecular Imaging (MI) and Magnetic Resonance (MR) contrast agents are at the forefront of medical research and drug discovery.. Current research in MI focusses on e.g. simultaneous microscopy and whole body imaging, so-called "multimodal" imaging. MR enables high spatial resolution and the ability to simultaneously obtain physiological and anatomical information, whereas optical (fluorescence) imaging allows for rapid screening.. Combining the advantages of both imaging modalities allows: e.g. co-validation of the accumulation of targeted MR contrast agents at a target site. We are combining components of both imaging modalities in the same compound.. ...
Purpose Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provides an advantage over conventional MRI in that DCE-MRI provides anatomical, physiological, and hemodynamic information about neoplastic lesions. Our aim in this study was to evaluate spinal metastases from hypervascular renal cell carcinoma (RCC) and hypovascular prostate carcinoma (PC) using a T1 DCE-MRI perfusion technique and to assess the sensitivity and specificity of the perfusion parameters obtained. Materials & Methods A total of 40 patients with spinal metastases and either PC or RCC as the primary tumor were studied. DCE perfusion parameters-vascular permeability (Ktrans), plasma volume (Vp), wash-in, and peak-enhancement were measured to assess their potential as discriminators of tumor histology. A Mann-Whitney U test, at a significance level of p≤0.01, was performed to quantify and compare the significances of the perfusion parameters of PC and those of RCC. Results Of the four perfusion parameters ...
Fluorescent molecules targeted to reveal information on tissue function have been used as research tools in ex vivo and subsurface characterization of diseased tissue for years. Exploiting this specificity for in vivo imaging through centimeters of tissue is a challenging problem due to high signal attenuation from light absorption and elastic scattering. Therefore, diagnostic imaging of exogenous contrast agents through tissue requires model-based techniques which even under the best of circumstances suffer from relatively poor spatial-resolution and non-uniform sensitivity throughout the imaging field. These challenges are addressed by incorporating tissue structural information derived from a highly resolved clinical imaging modality into diffuse fluorescence and spectrally-constrained absorption tomographic image reconstruction routines. A multichannel spectroscopic molecular imaging system capable of collecting spectrally-resolved near-infrared transmission and luminescent data from within ...
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Abstract- Medical imaging is one of the most important application areas of digital image processing. Processing of various medical images is very much helpful to visualize and extract more details from the image. Many techniques are available for enhancing the quality of medical image. For enhancement of medical images, Contrast Enhancement is one of the most acceptable methods. Different contrast enhancement techniques i.e. Linear Stretch, Histogram Equalization, Region based enhancement, Adaptive enhancement are already available. Choice of Method depends on characteristics of image. This paper deals with contrast enhancement of MRI images and presents here a new approach for contrast enhancement based upon Adaptive Neighborhood technique. A hybrid methodology for enhancement has been presented. Comparative analysis of proposed technique against the existing major contrast enhancement techniques has been performed and results of proposed technique are promising. Keywords: Histogram Equalization,
TY - JOUR. T1 - Endoluminal contrast for abdomen and pelvis magnetic resonance imaging. AU - Gupta, Mohit K.. AU - Khatri, Gaurav. AU - Bailey, April. AU - Pinho, Daniella F.. AU - Costa, Daniel. AU - Pedrosa, Ivan. PY - 2016/7/1. Y1 - 2016/7/1. N2 - Magnetic resonance (MR) imaging of the abdomen and pelvis can be limited for assessment of different conditions when imaging inadequately distended hollow organs. Endoluminal contrast agents may provide improved anatomic definition and detection of subtle pathology in such scenarios. The available routes of administration for endoluminal contrast agents include oral, endorectal, endovaginal, intravesicular, and through non-physiologic accesses. Appropriate use of endoluminal contrast agents requires a thorough understanding of the clinical indications, available contrast agents, patient preparation, and interaction of the contrast agent with the desired MR imaging protocol. For example, biphasic oral enteric contrast agents are preferred in MR ...
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At the Institute for Basic Science (IBS) in South Korea, researchers have developed a new type of MRI contrast agent that only lights up when near a target
Press Release issued Mar 26, 2014: Reportstack, provider of premium market research reports announces the addition of France Contrast Media Injectors Market Outlook to 2020 market report to its offering France Contrast Media Injectors Market Outlook to 2020
As stated in the report North America holds a significant share in the market. The trend is unlikely to change and North America may continue holding its position. The growth witnessed is attributable to high presence of key developers in nations such as Canada and U.S.. The Asia Pacific Contrast Media market is expected to expand at a promising CAGR during the forecast period. The constantly improving healthcare infrastructure in the region is expected to contribute to Asia Pacific market expansion.. The analysis conducted in the report is based on industry leading tools and techniques. The report prepared by Fortune Business Insights, offers innovative strategies based on various analysis. The information offered is collected from reliable primary and secondary sources. The report also provides information about key companies operating in the market.. Major Table of Content For Contrast Media Market: ...
Combination contrast media, imaging agents, and radiopharmaceuticals - Radiopharmaceuticals and contrast media - Drugs and Pharmaceutical Products
By observing the real-time behavior of focal liver lesions at three vascular phases (arterial, portal-venous, and late), contrast-enhanced ultrasound (CEUS) has been successfully applied to differentiate benign from malignant hepatic nodules. In recent years, numerous studies highlighted the usefulness of CEUS also for other applications such as abdominal trauma, renal, pancreatic, thyroid, and inflammatory bowel diseases, supporting its role even in differentiating benign from malignant splenic nodules. Therefore, the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) recently updated the guidelines for the use of ultrasound contrast agents in clinical practice, pointing out the indication to characterize splenic parenchymal inhomogeneity or suspected lesions found on conventional ultrasound (BUS ...
OBJECTIVE The purpose of this study was to compare two time delays between injection of contrast material and helical CT scanning to determine relative conspicuity of hepatic metastases. SUBJECTS AND METHODS Twenty-five patients with hepatic metastases were examined with helical CT. The first imaging phase was initiated at 50 sec and the second 75 sec after the start of contrast material injection (3 ml/sec, 150 ml). Differences in lesion and liver attenuation were measured quantitatively. Four radiologists used a 5-point scale to assess lesion conspicuity subjectively. RESULTS Mean differences in enhancement between liver and lesion were 41 H during the first phase and 59 H for the second phase (p = .0001). Radiologists conspicuity score averaged 2.4 for lesions in the first phase versus 3.3 for lesions in the second phase (p = .0001). In 56 (88%) of 64 lesions, objective measurements showed greater enhancement of lesions during the later phase. Radiologists found 60 (94%) of 64 lesions to be more
Celera Genomics saw its share price take a small hike yesterday after inking a deal with Schering AG - soon to be merged with Bayer - for its cathepsin S inhibitor programme in autoimmune disease. It comes with potential milestones worth up to $360 million and double-digit royalties, on top of a $5 million upfront payment, half of which will be paid now and the remainder after the rights are transferred, which is forecast to be in the next four months. - News - PharmaTimes
Adaptive Contrast Agent Medical Imaging - System parameters for contrast agent medical imaging are conveniently set. A simplified contrast agent configuration is provided where an appropriate contrast agent detection technique and/or contrast agent imaging parameters are achieved consistently and more often then exists with current methods. Examination workflow is improved for contrast agent studies by offering one contrast agent imaging mode or configuration that is dynamically determined and optimized based on the users selected transmit level and/or a real-time measurement of the contrast agent signals. A simplified user interface provides one contrast agent imaging mode without a need to switch between multiple modes or contrast agent detection techniques and associated contrast agent imaging parameters. The contrast agent detection technique and imaging parameters are adjusting or selected based on changes in the transmit levels for contrast agent imaging. Either a single user input ...
Contrast-induced nephropathy (CIN) is a significant problem resulting from the use of iodine contrast agents in computed tomography (CT) scans and cath lab angiography. It can have a negative.... ...
Contrast media, also called contrast agents, are used to enhance the blood and perfusion in tissues.This includes iodine based contrast for on computed tomography (CT), gadolinium based agents for MRI and lipid bubble contrast agents used in ultrasound.
This report analyzes the worldwide markets for Imaging Agents in Millions of US$. The major product segments analyzed are Contrast Media (X-Ray, MRI, & Ultrasound), and Diagnostic Radiopharmaceuticals. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, Middle East, and Latin America. Annual forecasts are provided for each region for the period of 2000 through 2015. The report profiles 67 companies including many key and niche players worldwide such as AMAG Pharmaceuticals Inc., Amersham Plc, Bayer Schering Pharma AG, Bayer HealthCare Pharmaceuticals, Bracco Group, E-Z-EM Inc., Covidien, Cytogen Corp., Daiichi Sankyo Company Limited, Eisai Co., Ltd, EPIX Pharmaceutical Inc., Guerbet Group, and Lantheus Medical Imaging. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources ...
TY - JOUR. T1 - Non-contrast-enhanced computerized tomography and analgesic-related kidney disease. T2 - Report of the National Analgesic Nephropathy Study. AU - Henrich, William L.. AU - Clark, Richard L.. AU - Kelly, Judith P.. AU - Buckalew, Vardaman M.. AU - Fenves, Andrew. AU - Finn, William F.. AU - Shapiro, Joseph I.. AU - Kimmel, Paul L.. AU - Eggers, Paul. AU - Agodoa, Larry E.. AU - Porter, George A.. AU - Shapiro, Samuel. AU - Toto, Robert. AU - Anderson, Theresa. AU - Cupples, L. Adrienne. AU - Kaufman, David W.. PY - 2006/5. Y1 - 2006/5. N2 - Previous studies suggested that the non-contrast-enhanced computerized tomography (CT) scan is a highly reliable tool for the diagnosis of analgesic-associated renal disease. However, this issue has not been addressed in the US population. A total of 221 incident patients with ESRD from different regions of the United States underwent a helical CT scan and detailed questioning about drug history. Specific renal anatomic criteria were developed ...
Contrast-enhanced CT studies are highly diagnostic and involve little physiological stress. To obtain the best results, protocols for contrast enhancement must take into consideration the patient...
This study was conducted to compare the effects of different doses of gadodiamide during serial MR imaging on rCBV maps. The double dose of gadodiamide injection (0.2 mmol/kg) was superior to the 0.1 mmol/kg dose in terms of CNR, image quality, contrast effect, sensitivity, and specificity. Even though the 0.3 mmol/kg dose was slightly better than the 0.2 mmol/kg dose with respect to CNR, image quality and contrast effects were less favorably rated, and sensitivity and specificity were also lower. These results are in agreement with preliminary results of testing doses of 0.1 and 0.2 mmol/kg (22, 29, 30).. The higher doses of gadodiamide (0.2 and 0.3 mmol/kg) gave superior results with respect to CNR. We hypothesize that the 0.1 mmol/kg dose was too small to induce a sufficient susceptibility effect with the sequences and field strength used. Possibly, a change in the injection protocol with bolus injection rates exceeding 5 mL/s would result in a more compact bolus formation and subsequently in ...
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Medical Radiology. Linköping University, Center for Medical Image Science and Visualization, CMIV.ORCID iD: 0000-0002-2167-2450 ...
Results: The CT dose index volume decreased by 23.68% and 23.57% and the dose length product dropped by 25.59% and 18.45% in the arterial and portal venous phases, respectively, in the experiment than control group. The contrast dose was reduced by 16.86% in the experiment group. In the 70keV+30% IR group, the noise of liver, pancreas and sacrospinal muscle were significantly (P,0.05) lower in both phases than the control group, and the score was higher than in the control group (P,0.05). In the 55keV+ 50% IR group, the arterial contrast-to-noise ratio and scores were significantly (P,0.05) higher in the arterial phase but the sacrospinal muscle noise was significantly (P,0.05) lower than in the control group. ...
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Kelm, B M, Müller, N, Menze, B H and Hamprecht, F A (2006). Bayesian Estimation of Smooth Parameter Maps for Dynamic Contrast-Enhanced MR Images with Block-ICM. Proc Computer Vision and Pattern Recognition Workshop (Mathematical Methods in Biomedical Image Analysis). IEEE Computer Society. 96-103 ...
article{BUT110377, author="Sebastian {Schäfer} and Kim {Nylund} and Fredrik {Sævik} and Trond {Engjom} and Martin {Mézl} and Radovan {Jiřík} and Georg {Dimcevski} and Odd Helge {Gilja} and Klaus {Tönnies}", title="Semi-automatic motion compensation of contrast-enhanced ultrasound images from abdominal organs for perfusion analysis", annote="This paper presents a system for correcting motion influences in time-dependent 2D contrast-enhanced ultrasound (CEUS) images to assess tissue perfusion characteristics. The system consists of a semi-automatic frame selection method to find images with out-of-plane motion as well as a method for automatic motion compensation. Translational and non-rigid motion compensation is applied by introducing a temporal continuity assumption. A study consisting of 40 clinical datasets was conducted to compare the perfusion with simulated perfusion using pharmacokinetic modeling. Overall, the proposed approach decreased the mean average difference between the ...
Within the lipoprotein family, historically LDL has been most exploited as an imaging agent. The idea of HDL as an imaging agent is relatively new, and only a limited number of HDL-based nanoparticles for imaging have been reported. Even so, there are already examples of HDL imaging particles of very sophisticated design.. Our own work has focused primarily on the development of HDL-based contrast agent for the detection of macrophages in atherosclerotic plaques with MRI as well as with CT and optical techniques. To improve detectability and to allow a lower dose to be injected, several modifications have been introduced to enhance the contrast generating properties. For example, the nanocrystal HDL platform allows the inclusion of nanoparticulate diagnostically active materials. In addition, amphiphilic Gd chelates can be used that exhibit improved relaxivity (eg, by including a so-called q=2 MRI contrast agent as reported by Briley-Saebo et al69).. In addition to the potential imaging of the ...
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In the Global Contrast Media Injectors Industry Market Analysis & Forecast 2018-2023, the revenue is valued at USD XX million in 2017 and is expected to reach USD XX million by the end of 2023, growing at a CAGR of XX% between 2018 and 2023. The production is estimated at XX million in 2017 and is forecasted to reach XX million by the end of 2023, growing at a CAGR of XX% between 2018 and 2023.
The Global report entails the overall and all-encompassing study of the "Contrast Media Injector Market" with all its relevant factors that might have an influence…. ...
... by Ruth Dennis http://i.imgur.com/33EI1C8.png Pages: 38 slices Publisher: -- Edition: 2002, WSAVA, FECAVA, AVEPA Language: English
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Researchers of Vrije Universiteit Brussel developed a new type of fluorescent contrast liquid for use in cancer surgery. This allows the surgeon to carry out operations in a more precise and accurate way. Both patients survival rates and quality of life should improve significantly as a result of the new technique.
زمینه و هدف: استفاده از مادۀ حاجب در تصویربرداری، کلیه-ها را در معرض آسیب قرار داده که به آن نفروپاتی ناشی از کنتراست یاContrast-Induced Nephropathy (CIN) گفته می‌شود. این اصطلاح زمانی به-کار برده می‌شود که افزایش کراتینین سرم بیش از 25% از سطح پایه یا بیش از 5/0 میلی-گرم در دسی-لیتر طی 3-2 روز بعد از تجویز کنتراست، بدون حضور بیماری-های دیگر کلیوی رخ دهد. بروز CIN در جمعیت بزرگ‌سالانی که آنژیوگرافی قلبی شده-اند، حدود 20-10% است، ولی مطالعات در این زمینه در کودکان بسیار محدود است. هدف از این مطالعه بررسی بروز این عارضه در کودکان مبتلا به بیماری مادرزادی قلبی بود. روش بررسی: در این
Prevention centers around avoiding volume depletion. This has led to trials and practices using oral hydration, volume expansion with IV fluids and bicarbonate, and both holding and using diuretics. O... more
the abdominal aorta and its main vessels." - CEUS (11/19/2009): " Complete portal vein thrombosis extended to the ... with contrast medium, Abdominal MR with contrast medium, CEUS, Chest CAT scan with contrast medium, Esophagogastroduodenoscopy, Total .... ...
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At the recent AACR-NCI-EORTC meeting (October-November 2001) in Miami, FL, Pat Price from the University of Manchester, Manchester, United Kingdom (18), reviewed the most reliable methods to assess the efficacy of antiangiogenic compounds using either functional computed tomography, dynamic contrast-enhanced MRI, ultrasound, or 15O-positron emission tomography scanning techniques. Emphasis was on the complexity of the measurement and the need to validate these techniques as potential early surrogate end points for a variety of cancer treatments. The availability of an imaging tool combining either MRI, positron emission tomography, or ultrasound scanning with a biological readout system, which is able to correlate or even predict a successful tumor immune response, would greatly facilitate future clinical designs. Nevertheless, these are measurements of the "nonimmune" parameters. In immunotherapy it is important to be able to measure an "effective," tumor-specific immune response.. If the ...
Schering Corp. said that My-K Laboratories Inc. of Skokie agreed to a permanent injunction prohibiting My-K from making or selling products similar to Schering`s ``Afrin`` nasal decongestant. My-K
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CT contrast is associated with many harms that we overlook in medicine. Might its cardiovascular effects be related to patients crashing in CT?
Contrast enhancement has an important role in image processing applications. Conventional contrast enhancement techniques either often fail to produce sati
Low-biofouling membrane: We aim at investigating the polymer/additives couples that would possibly lead to best low-biofouling properties. The preparation method is the blending method coupled to a phase inversion process. This technique does not involve any other unit operation in the membrane preparation process, compared to surface modification processes, and is believed to enhance hydration and low-biofouling properties of the whole membrane ...
Even in patients at low risk for contrast-induced nephropathy, the choice of contrast medium for CT scans can have a big impact on safety.
While there has been considerable interest in the development of imaging biomarkers for use in clinical trials, most DCE-MR imaging studies have focused on identifying correlates of vascularity and angiogenesis.41 This study identified an unexpected positive correlation between ve, a parameter thought to reflect extravascular extracellular space volume, and mitotic activity. No relationships were identified among the previously described DCE-MR imaging prognosticators, Ktrans and vp, and mitotic activity or between vascular patterns and DCE-MR imaging measures.. The parameter ve is often overlooked in DCE-MR imaging studies. In cerebral tumors, it has the potential to distinguish intra- from extra-axial tumors42,43 and exhibits increased values with increasing tumor grade.33,34,42,44 It has also demonstrated sensitivity in identifying changes in response to treatment with corticosteroids, with decreases in ve presumably reflecting a reduction in interstitial edema.45,46 In a study of vestibular ...
The purpose of this study is to see if dynamic contrast enhanced (DCE) MRI imaging makes it possible to distinguish benign conditions of the breast from