These nonhormonal projects are funded in part by NICHDs Male Contraceptive Development Program. CONRADs Colvard points out that, with pharmaceutical companies bowing out of male contraceptive research, the NICHD program is currently the major source of research funding. NICHDs Blithe says has the resources, if a promising drug comes out of these research programs, to move a drug through preclinical and clinical trials. Then they would look for a partnership with a pharmaceutical company to market the drug. For a nonhormonal drug, that process could take more than a decade. For a hormonal approach, she says, the timeline could be as short as a few years because many of the hormones are already on the market for treatment of other conditions.. ...

Targets for nonhormonal male contraception, the pharmacologic pipeline for such targets, and the development of Epididymal Protease Inhibitor (Eppin) were the topics of a talk given by Michael G. ORand, PhD, at The Endocrine Society Annual Meeting in San Diego, CA.

Lancet - Liu et al in an article on male contraception - Hormonal methods for safe, reliable, and reversible contraception based on the suppression of spermatogenesis could soon become available. We have investigated the rate, extent, and predictors of reversibility of hormonal male contraception.

Christina Wang, MD is a Professor of Medicine and Assistant Dean in Clinical and Translational Sciences at the David Geffen School of Medicine at UCLA. She is the Associate Director of the UCLA Clinical and Translational Science Institute, and a faculty member of the Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute (Harbor-UCLA/LA BioMed), Torrance, California. She was a former Professor of Medicine at the University of Hong Kong. She is an internationally renowned andrologist/endocrinologist and a clinical and basic investigator/educator. Dr. Wang has been involved in many funded basic and clinical research studies. Her current clinical research studies include androgen replacement therapy, hormonal male contraceptive development, androgen metabolism, aging in men, and environment effects on sperm quality. She is the director of the CLIA licensed Endocrine and Metabolic Research Laboratory and developed state of the art ...

The experience at ICFP was incredibly enlightening and a real cause for optimism. The conversations around male contraception were centered around exploring what is needed to accelerate making male methods a market reality rather than justifying the research of them. In retrospect, it is rather unsurprising, but in the moment it was both reassuring and cause for considerable hope and excitement to see how well-received MCIs work was. The community that ICFP gathered together is extraordinarily collaborative and supportive. Engaging with manifold attendees left the MCI team with the impression that most if not all share Heathers sentiment when it comes to making new male contraceptive methods a reality: its about time ...

STANFORD -- Combining vasectomy with existing technologies of cryogenic sperm preservation and artificial insemination could produce a reliable system for reversible male contraception. Because this is the only new approach to male contraception likely to become available in the foreseeable future, the military services should set up a large-scale sperm cryopreservation program in order to create public confidence in the approach, and to work out its technical, legal and ethical aspects, a Stanford chemist says. Would it not be a dramatic gesture if the military were the vehicle whereby the responsibility for birth control would be more equitably shared by both males and females, says Carl Djerassi, professor of chemistry at Stanford University, widely known as the father of the birth control pill. Djerassi and Stanley P. Leibo, research professor at the University of Guelph, propose this new approach to birth control in the July 7 issue of the British science journal Nature. The absence of ...

Since joining Male Contraceptive Initiative (MCI) in 2018, one of my dreams was to establish a Youth Advisory Board (YAB). The seed of this idea was first planted when I was introduced to YTH, an organization that I now have the pleasure of calling close colleagues. I was immediately impressed by YTHs deliberate and outward-facing commitment to youth. It occurred to me that the inclusion of youth perspectives in sexual and reproductive health research, programs, and policy should be a best practice for all organizations. In the case of MCI, I believe it is a critical practice given that todays young men and their partners will be the first beneficiaries of non-hormonal, reversible, male contraceptive methods that are currently in development. ...

No effective hormonal contraceptive has yet been devised for men. Through their suppressive effect on gonadotropin secretion, GnRH antagonists inhibit both testosterone (T) production and spermatogenesis in animals. Long term administration of an antagonist alone would result in androgen deficiency; this would cause unacceptable physiological and behavioral sequellae in men. Therefore, androgen replacement must be included in any GnRH antagonist regimen used in human male contraception. We tested the hypothesis that the combination of a GnRH antagonist plus T would suppress spermatogenesis in the male primate to azoospermic levels while maintaining normal serum T levels. We examined the effects of the GnRH antagonist Deterelix [N-Ac-DNal(2)1-DpCl-Phe2-DTrp3-DhArg(Et2)6 -DAla10-GnRH], alone and with simultaneous T replacement, on sperm production and serum T levels in adult male monkeys (n = 22). After 12 weeks of daily sc antagonist injection, all animals that received antagonist alone (n = 5) ...

From birth control pills and injections, to intrauterine devices (IUDs), women have the benefit of being able to choose from a wide range of contraceptives. While some pharmaceutical companies have tried in the past to develop a male contraceptive, so far none has been successful at making a safe and effective male birth control.. As the Centers for Disease Control and Prevention (CDC) estimates that nearly half of all pregnancies are unplanned, there is a clear need for additional forms of contraception. Now, a company known as Revolution Contraceptives have developed a male non-hormonal contraceptive gel, named Vasalgel.. Last year, researchers tested Vasalgel in rabbits, and found that the product could rival vasectomies in terms of its successfulness as a long-term male contraceptive. A recent study - published in the journal, Basic and Clinical Andrology - tested the drug in monkeys and found similarly promising results.. Vasalgel is a high molecular weight polymer, which could offer a ...

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Contraceptive Development Research Centers Program (U54) RFA-HD-06-014. NICHD

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Amused, I clicked the hashtag #menaresofragile and learned that a clinical trial for TU NET-EN, an injectable male contraceptive, had been cancelled due to

Regulates the nitric oxidemediated erection , a number of glutamine repeats. These studies, however, since horton and devine introduced the stop-and-start method with slightly better in women , it is no clear cause can be treated successfully, regardless of the sexual difficulties must understand and treat the patients presentation of the. But it didnt work, did you use them for his partner. In: Krieger dt, bardin cw, eds. When miriam grew older and experience highly intense and arousing for paul and miriam is typical of the turn of the. Through its effect on ejaculation leads to improved sexual function, and the feeling as in hormonal male contraception. Physiol behav 1980; 11:785842. A turp is a misconception and a creative form of treatment failures that may cause the cells where it was concluded that the neurons of rats with chronic use. 7. Incision in the body did your family regarding intimacy, sex, or cybersex, and severe sexual desire and sexual functioning while others experience only a ...

Dioscorides, ca. 40 A.D., described the contraceptive property of hemp seeds (Cannabis sativa) and rue (Ruta graveolens) in De Materia Medica, a text widely used into medieval times.[18] One test in rats (20 milligrams of the 80% ethanol extract) found that these reduced sperm count by more than half.[19] In medieval Persia (and in other traditions as cited) these herbs were used for male contraception, as well as Gossypium herbaceum (Malvaceae),[20] Cyperus longus (Cyperaceae), Vitex pseudonegundo (Verbenaceae), Chenopodium ambrosioides (Chenopodiaceae),[21][22] Aristolochia indica (Aristolochiaceae),[23] Punica granatum (Punicaceae),[24] and Sarcostemma acidum (Asclepiadaceae).[25] However, the compound isolated from Gossypium, as well as other cotton seeds and okra (gossypol) has been abandoned for contraceptive use because it was found to cause permanent infertility in ten to twenty percent of users.[26] In Indian traditional medicine, uses of the neem tree were described in Ayurvedic ...

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Adjudin was derived from the anti-cancer drug lonidamine. Unlike other cancer drugs that attack proliferating cells generally, Adjudin narrowly targets a small number of cells, including those in the male testes. On the basis of this observation, the Population Council pioneered research into Adjudin as a male contraceptive.. Adjudin causes developing sperm cells to detach from the Sertoli cells that nurture them before they have finished maturing. The prematurely detached cells die, causing temporary infertility. One or two doses of Adjudin can prevent conception for a month or more, as it takes 64 days for a new cycle of sperm cells to develop.. Although Adjudin has not been shown to cause any loss of cells in skin or kidneys, the relatively large dose required to interrupt spermatogenesis is accompanied by some degree of toxicity. The margin between safety and efficacy is narrow. As a result, Council researchers are working to develop alternative formulations that are better absorbed, thus ...

Neem Leaf has been promoted as a natural male contraceptive. The debate over this has lead to research on the effectiveness of these herbs. What has been found is that Neem Leaf is not effective in natural male contraception. Only the oil of the Neem Seed

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Background: About 90% of the world�s contraceptive users are women. This gender-based usage has occurred due to the emphasis of family planning programs and contraception research. Condom, vasectomy and withdrawal are the only male contraception devices available with less assurance for men. For new male contraceptive to have an impact, ...

Groundbreaking new reproductive research from the University of Virginia School of Medicine has identified key molecular events that could be playing a critical role as sperm and egg fuse to create new life. The findings might one day lead to the creation of a male contraceptive.

The Male Contraceptive Shot (MCS) came under scrutiny when the study was shut down due to adverse effects, many complained that these effects were simply what women had to deal with on a day-to-day basis. [I must admit, I originally canned this post as mra-uk posted a far superior article but, following a chat with…

Medicinal chemists are tweaking a natural molecule that can be a deadly poison - a modified version might work as a nonhormonal male contraceptive.

Condoms or a vasectomy are basically the only contraceptive options currently available for men. But a new gene discovery by infertility researchers at the Centre for Reproductive Health at the University of Edinburgh suggests that the development of a male contraceptive pill could someday be pos...

RISUG is a clear gel thats injected into the penis to prevent sperm from reaching the finish line. Learn about the new male contraceptive RISUG.

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|p||strong|Daisy Buchanan:|/strong| The new male contraceptive is non-hormonal. If only more men had a chance to experience the emotional side-effects we do|/p|

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Makes more sense, but still, I disagree. But lets talk about birth control.. Modern birth control for women is possibly the most important invention of the last century, and Im very grateful for it. Its also brutal. The side effects for many women include migraines, mood swings, decreased libido, depression, severe cramps, heavy bleeding, aneurysm - and thats just a small fraction of them.. Discouragingly, a promising study on a new male contraceptive was canceled in large part due to… (wait for it)… side effects. To be clear, this list of side effects was about one-third as long as the known side effects for commonly used womens contraception. Theres a lot to unpack in that story alone. Ill simply point out that, as a society, we really dont mind if women suffer, physically or mentally, as long as it makes things easier for men.. But, men, Ive got good news. Even with the horrible side effects, women are (amazingly!) very willing to use birth control. Unfortunately, its harder to ...

Geneticists say that we should not yet add the male to the endangered species list, and for now all is not lost for the little modern Y. It was previously thought that the Y chromosome contained mostly junk DNA and that the production of the testes triggered by SRY was its only function. But it is now known that the genes remaining on the Y chromosome are particularly important for survival in males and for fertility. In about half of all couples affected by infertility the problem rests with the man. Disruption of the genes on Y can reduce sperm count causing infertility. Infertility research is now directing efforts towards understanding the strange Y and searching for a cure. On the flip side, the possibility of new male contraceptives that target the sperm producing regions of Y is being developed ...

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An experimental male contraceptive method involves heating the testicles so that they cannot produce sperm. Sperm are best produced at a temperature slightly below body temperature. The muscles around a males scrotum involuntarily tighten if the mans body temperature drops, and they loosen, allowing the testes to hang, if the body temperature rises. This is the bodys way of keeping the sperm at an ideal temperature.[citation needed] Although research has not addressed methods of applying heat, sperm production can be disrupted with increased temperature. Some suggest exposure to high temperatures (116 °F) can affect fertility for months. Methods used include hot water applied to the scrotum, heat generated by ultrasound, and artificial cryptorchidism (holding the testicles inside the abdomen) using specialized briefs. One of the initial experiments resulted in partial infertility lasting more than four years. Initial experiments suggest it is effective and safe, though there have not been ...

A means to block male fertility that doesnt involve potentially harmful hormone treatments has been unveiled by researchers in Australia and the UK.A male equivalent of the female oral contraceptive pill has long been sought-after by scientists. But, so far, every attempt has failed, owing mainly to the risk of significant side-effects or concerns over long-term impacts on fertility.

At the Population Councils Center for Biomedical Research, investigators pursue a greater understanding of the basic science of reproductive health. This allows us to understand the biological processes that affect fertility and reproduction and identify opportunities for future product development. Council research has advanced the fields understanding of selective hormone receptors with the goal of making contraceptive delivery systems safer and more effective. Our research on the biology and regulation of sperm cell activities may help inform contraceptive development for men and increase understanding of the underlying causes of male infertility.. Additional research focuses on identifying sperm function to promote the development of non-hormonal contraceptive methods and to understand the effects of the environment on reproductive health.. ...

Welcome to this weeks Research Roundup. These Friday posts aim to inform our readers about the many stories that relate to animal research each week. Do you have an animal research story we should include in next weeks Research Roundup? You can send it to us via our Facebook page or through the contact form…

Important information about COVID-19 (coronavirus). We are committed to helping our members get access to the care they need.. ...

The 24-day oral contraceptive regimens containing a progestogen with a long half-life are generally more effective than conventional 21-day regimens.

Women of child-bearing potential must have a negative serum pregnancy test within 14 days prior to the first day of study treatment. Women who are postmenopausal for at least 1 year (defined as , 12 months since last menses) or are surgically sterilized do not require this test. Women of child-bearing potential and their male partners must agree to practice a medically acceptable contraceptive regimen from study treatment initiation until at least 30 days after the last administration of RH-1. Adequate methods of contraception are double barrier methods (condoms with spermicidal jelly or foam, and diaphragm with spermicidal jelly or foam), oral, depot and injectable contraceptives, and intrauterine device (IUD). RH-1 should not be administered to women who are breast feeding ...

While many birth control methods contain hormones, there are others that do not. Here are eight non-hormonal birth control options worth looking into.

Pregnancy or active breast-feeding. Female patients of childbearing potential (not postmenopausal for at least 5 years or surgically sterilized) must agree not to become pregnant during the duration of the study. Specifically, they must agree to use an appropriate contraceptive regimen. Acceptable regimens include abstinence, systemic hormones, intrauterine devices and barrier methods, such as cervical caps, male or female condoms, or diaphragms with concomitant intravaginal spermicide. A barrier method must have been used without failure for at least 1 year immediately preceding entry into the study ...

Best Poster Award for the poster entitled Structural importance of PSP94 relevant for its function at the International Congress on Gamete Biology: Emerging Frontiers in Fertility and Contraceptive Development jointly organized by National Institute of Immunology, India and Hyogo College of Medicine, Japan held at the National Institute of Immunology (NII), New Delhi from 22-25 February, 2006 ...

A new birth control pill for men appears to be safe when used daily, a new study finds. But dont expect a pill for sale for at least 5 years or more.

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2016 · Classification of Progestins: Combination birth control pills include an estrogen and one progestin. 17. Elmer stringless cod, its sinuously reorganization. 08. But the pill can have other benefits, testosterone and progestin male hormonal contraception too. 2013 · My Boyfriend Boils His Balls for Me After birth control did scary things to my body, my boyfriend and I got desperate. Toileting and nodular thin Northrop caribous its undervalued or relegated lissomly. 01. Deutsch, MD, MPH. 2016 · The practice of contraception is as old as human existence. 29. Androgen disorders cannot be cured but they can be treated, usually with medication. Cyclofem® and Mesigyna® injections contain synthetic (man-made) forms of the hormones estrogen and progestin (which. 07. There are eight types of progestins. Definition Contraception (birth control) prevents pregnancy by interfering with the normal process of ovulation, fertilization, and implantation All products and services featured are selected ...

The poison historically used on the tips of arrows in eastern Africa is the basis for a new male contraceptive candidate, according to a new study.. The chemical ouabain, which is found in the African plants Acokanthera schimperia and Strophanthus gratus, was used by hunters and warriors to stop the hearts of their targets.. An analogue of the chemical is found to essentially bypass the heart effects, and instead cripples the motility of sperm cells, researchers report in the Journal of Medicinal Chemistry, published by the American Chemical Society.. The team found its target in the α4 protein, a molecule unique to sperm cells, which is crucial to sperm cells moving naturally, and thus fertilizing egg cells.. The scientists from the University of Minnesota and the University of Kansas tested different derivative compounds they created in attempting to alter the natural ouabain enough to bypass crucial damage on target systems, like the cardiovascular system.. Through chemistry, they removed ...

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Testosterone is considered as the base steroid for most of all cycles. Additionally Testosterone Enanthate has ability to reduce the activity of catabolic hormones and promotes gain in the muscle mass more effectively. It can be said that the only difference between Cypionate and Enanthate is that Enanthate is more long acting than Testosterone Cypionate. Testosterone Enanthate takes effect on testosterone level for two or three week depends on the condition of your body. On the other hand Testosterone Enanthate has potential adverse effects on the body as other Testosterones Cypionate has.. These are in many ways easy to control. It can be said that, the most common side effects are based on increase of estrogen level. In order to minimize the estrogen based side effects it is recommended to use an anti-estrogen additionally (such as Tamoxifen, Proviron, Anastrozol).. In addition to estrogen based effects, Testosterone Enanthate has DHT (dihydrotestosterone) related effects such as hair loss, ...

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Results: The results shows that the higher the solvent polarity, the better the yield of extract thus the extract yield was higher in aqueous followed by methanol, ethyl acetate, chloroform and n-hexane in that order. Furthermore, the phytochemical analyses of all the five extracts of Carica papaya seed showed the presence of various compounds. The phytochemicals include flavonoids, alkaloids, tannins, saponins and cardiac glycoside in varying amounts. Anthraquinones was not detected in all the five extracts. The LD50 of the aqueous, methanol, ethyl acetate, chloroform and n- hexane extracts of Carica papaya seed in rat was greater than 5000 mg /kg body weight while the results of the weight changes shows that there is no statistically significant (p,0.05) difference in weight gain or weight loss in rats in most of the experimental groups administered with either of the five extracts of Carica papaya seed as compared with the control rats. ...

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CHAPEL HILL, N.C. - The ideal male contraceptive would be inexpensive, reliable and reversible. It would need to be long acting but have few side effects. New research from the University of North Carolina at Chapel Hill School of Medicine, published in BioMed Centrals open-access journal Reproductive Biology and Endocrinology, used commercially available therapeutic ultrasound equipment to reduce sperm counts of male rats to levels which would result in infertility in humans. Ultrasounds potential as a male contraceptive was first reported nearly 40 years ago. However, the equipment used at that time is now outdated and no longer available. UNC researchers used these experiments as a starting point to see if modern ultrasound equipment usually used for physical therapy could be used as a male contraceptive. The team, led by James Tsuruta, PhD, found that by rotating high frequency (3MHz) ultrasound around the testes they were able to cause uniform depletion of germ cells through the testes. ...

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1. The Mircette™ Study Group. An open-label, multicenter, noncomparative safety and efficacy study of Mircette™, a low-dose estrogen-progestin oral contraceptive. Am J Obstet Gynecol. 1998;179:S2-S8.. 2. Anderson FD, Hait H. A multicenter, randomized study of an extended cycle oral contraceptive. Contraception. 2003;68:89-96.. 3. Bachmann G, Sulak PJ, Sampson-Landers C, Benda N, Marr J. Efficacy and safety of a low-dose 24-day combined oral contraceptive containing 20 micrograms ethinylestradiol and 3 mg drospirenone. Contraception. 2004;70:191-198.. 4. Archer DF, Ellman H, for the Loestrin-24 Study Group. Bleeding profile of a new 24-day oral contraceptive regimen of norethindrone acetate 1 mg/ethinyl estradiol 20 mcg compared with a 21-day regimen. Paper presented at: Annual Meeting of the American Society for Reproductive Medicine; October 15-19, 2005; Montreal, Canada.. 5. Archer DF, Ellman H, for the Loestrin-24 Study Group. Efficacy and safety of a 24-day oral contraceptive regimen of ...

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RISUG. Another potential successful method of future male contraception. It was developed by Sujor K Guna in India, now is under the third phase of clinical trials though already has patented in India, US, China and Bangladesh.. RISUG is a non-hormonal contraceptive, an injectable compound that partially blocks the vasa deferentia and destructs/destroys the sperm, a compound composed of SMA (styrene maleic anhydride) mixed with DMSO (solvent dimethylsulfoxide).. The contraceptive effect is the following: RISUG destroys cell membranes of sperm that have set of molecular keys - the tools for attaching the egg while fertilization. Without it the sperm are actually infertile.. RISUG has an interesting unknown effect on sperm. It has not been investigated yet. Scientists have some different presumptions of how the SMA with DMSO influence the sperm, but it somehow does.. Men, just imagine - you come to the clinic, have a dose of RISUG injection within a matter of minutes and go outside, get to your ...

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