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Gurung, S., Asante, E., Hummel, D., Williams, A., Feldman-Schultz, O., Halloran, M., Sittaramane, V. and Chandrasekhar, A., (2018) Distinct roles for the cell adhesion molecule Contactin2 in the development and function of neural circuits in zebrafish. Mechanisms of Development : 152: 1-12.. Kassim, Y. M., Al-Shakarji, N. M., Asante, E., Chandrasekhar, A. and Palaniappan, K., (2018) Dissecting branchiomotor neuron circuits in zebrafish - Toward high-throughput automated analysis of jaw movements. IEEE International Symposium on Biomedical Imaging (ISBI): 943-947.. Chandrasekhar, A., Guo, S., Masai, I., Nicolson, T. and Wu, C-F., (2017) Zebrafish: from genes and neurons to circuits, behavior and disease. Journal of Neurogenetics : 31: 59-60.. Allen, J., Bhattacharyya, K., Asante, E., Almadi, B., Davis, J., Schafer, K., Cox, J., Voigt, M., Viator, J. and Chandrasekhar, A., (2017) Role of branchiomotor neurons in controlling food intake of zebrafish larvae. Journal of Neurogenetics : 31: ...
In the present study, we give the first detailed work-up of patients with IgM autoantibodies against neurofascin-155. Whereas IgG autoantibodies to neurofascin-155 have been reported in several studies and are supposed to cause a distinct clinical phenotype,2 17 18 IgM neurofascin-155 autoantibodies have so far only been described in a few patients and some of them also tested positive for IgG anti-neurofascin.4 7 Autoantibodies were detectable by ELISA and were confirmed by preabsorption experiments and by Western blot in four patients, but not by binding assays with neurofascin-155 transfected HEK293 cells or murine teased fibres. Most likely, the latter methods were not sensitive enough to detect the low titres of autoantibodies as indicated by a higher sensitivity of ELISA when comparing with cell based binding assays using serum of a patients with high titres of anti-neurofascin-155 IgG.. C1q deposition was not detectable by CBA although IgM antibodies are supposed to bind complement. ...
Two experiments were carried out to address the question of whether PTPα and contactin associate in a cis or trans conformation. First, anticontactin precipitates were prepared from lysates of COS cells expressing either PTPα or contactin, or from cells coexpressing both PTPα and contactin ( Fig. 5 A, lanes 1-3), as well as from another sample made by mixing lysates from the cells expressing either contactin or PTPα ( Fig. 5 A, lane 4). Anticontactin immunoprecipitates prepared from coexpressing cells contained PTPα, but those from mixed cell lysates did not ( Fig. 5 A, bottom, lanes 7 and 8). The lack of detectable association of PTPα and contactin in the mixed lysates suggests that interaction cannot take place in a trans conformation. Still, this may require a particular presentation of these cell surface molecules in growing cells that cannot form in solubilized cell lysates. Therefore, contactin-expressing cells were trypsinized 24 h after transfection and replated in dishes ...
Principal Investigator:WATANABE Kazutada, Project Period (FY):1993 - 1994, Research Category:Grant-in-Aid for General Scientific Research (C), Research Field:Neurochemistry/Neuropharmacology
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.
The Total Therapy treatment regimens developed at the Myeloma Institute have demonstrated great improvement in treatment outcomes for multiple myeloma patients. However, some patients still relapse early during maintenance treatment meaning that better options are still needed. This study will evaluate a treatment regimen that alternates two different 3-drug regimens every eight weeks for patients that have previously completed autologous stem cell transplant. The two regimens are bortezomib, lenalidomide, and dexamethasone (VRD) which will be alternated with Elotuzumab, lenalidomide, and dexamethasone (Elo RD). Effectiveness will be measured by the depth of response (i.e., whether or not minimal residual disease (MRD) negative status is achieved). The rate of MRD negativity from this study will be compared to historical control data from the Total Therapy 4 trial which used continuous VRD maintenance therapy after stem cell transplant(s ...
|h1|The CLOCHE SS / 19 collection is based on shapes, volumes and textures, harmoniously blended with the color trends of the season. The convenience, refinement and gentle strokes that follow the body line reach their climax in these tracks.|/h1| |h1|ma
De tweelingbroers Oxide Pang Chun en Danny Pang kennen hun klassiekers, maar de beginnende regisseurs - alleen Oxide maakte tot nu toe een film, Ta fa likit (Who is running? uit 1998) - zitten nog in het stadium waarin ze zich moeilijk van hun voorbeelden kunnen loswrikken. Dat levert niet alleen open deuren, maar ook iets teveel bombast op: hun poging het extreem felle kleurenpalet van voormalig John Woo-cameraman Peter Pau te kopiëren is iets te opzichtig en de zwaar aangezette synthesizerscore veroorzaakt geborrel in de maagstreek. Maar in het ensceneren van brute geweldsscènes of achtervolgingen door broeierige steegjes tonen de heren zich meesters in de dop, en ze weten die typisch Aziatische uitbarstingen van energie, die de kijker zo aangenaam naar het hoofd kunnen stijgen, goed over te brengen ...
LGI1/CASPR2-antibody encephalitis is an autoimmune encephalitis in which antibodies target LGI1 (leucine-rich glioma inactivated 1) or CASPR2 (contactin-associated protein 2). Initially, typically, family members notice seizures and/or that their relative becomes forgetful, confused, drowsy and withdrawn.
BACKGROUND: Monoclonal antibodies (mAbs) towards CGRP or the CGRP receptor show good prophylactic antimigraine efficacy. However, their site of action is still elusive. Due to lack of passage of mAbs across the blood-brain barrier the trigeminal system has been suggested a possible site of action because it lacks blood-brain barrier and hence is available to circulating molecules. The trigeminal ganglion (TG) harbors two types of neurons; half of which store CGRP and the rest that express CGRP receptor elements (CLR/RAMP1). METHODS: With specific immunohistochemistry methods, we demonstrated the localization of CGRP, CLR, RAMP1, and their locations related to expression of the paranodal marker contactin-associated protein 1 (CASPR). Furthermore, we studied functional CGRP release separately from the neuron soma and the part with only nerve fibers of the trigeminal ganglion, using an enzyme-linked immunosorbent assay. RESULTS: Antibodies towards CGRP and CLR/RAMP1 bind to two different ...
Browse Item # 75-001, CASPR/Neurexin IV in the Antibodies, Inc. catalog including Item #,Item Name,Description,Target,Applications,Clone,IgG Isotype,Species Reactivity,Validation,Type,Format,Cross Reactivity,Expected Banding Pattern,Host,Label,Antibo
Dr. Katherine Pang, PhD, JD, MBA, ThM, Psychologist, Dallas, TX, 75214, (469) 828-7609, I work with adolescents, individuals, couples, and families and use cognitive behavioral techniques and strategies to address a variety of mental health issues. My emphasis is on transformative change and equipping each one of my clients with the skills to overcome the complexities of lifes challenges and find ways to successfully navigate emotional and mental pain in the process of healing. I approach each client uniquely so as to develop a treatment plan and goals that are specific to your needs and concerns.
Buy The Pangs - Stalemates & Sad Pastimes [CD] at DeepDiscount.com. Music: Rock: 677242010922. Guaranteed Lowest Price. Free Shipping on Orders over $25!
7) X. Pang, M. J. Zhang, L. X. Zhou, F. Xie, H. Lu, W. He, S. B. Jiang, L. Yu and X. Y. Zhang. (2011) Discovery of a Potent Peptidic Cyclophilin A Inhibitor Trp-Gly-Pro. European Journal of Medicinal Chemistry. 46, 1701- ...
Pudney, Christopher R., Hay, Sam, Levy, Colin, Pang, Jiayun, Sutcliffe, Michael J., Leys, David and Scrutton, Nigel S. (2009) Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction. Journal of the American Chemical Society, 131 (47). pp. 17072-17073. ISSN 0002-7863 (Print), 1520-5126 (Online) (doi:10.1021/ja908469m) Hay, Sam, Pudney, Christopher R., McGrory, Tom A., Pang, Jiayun, Sutcliffe, Michael J. and Scrutton, Nigel S. (2009) Barrier compression enhances an enzymatic hydrogen-transfer reaction. Angewandte Chemie International Edition, 48 (8). pp. 1452-1454. ISSN 1433-7851 (Print), 1521-3773 (Online) (doi:10.1002/anie.200805502) Hay, Sam, Pang, Jiayun, Monaghan, Phillip J., Wang, Xi, Evans, Rhiannon M., Sutcliffe, Michael J., Allemann, Rudolf K. and Scrutton, Nigel S. (2008) Secondary kinetic isotope effects as probes of environmentally-coupled enzymatic hydrogen tunneling reactions. ChemPhysChem, 9 (11). pp. 1536-1539. ISSN ...
Chargers that you just cant afford to lose will soon become unnecessary. In the wireless world of Bluetooth, NFC, and Wi-Fi networking, all we might need will be a charging surface - without any cords, of course. You might think this has already been created by Tesla, but theres more.. There is a chance that remote charging may soon become a reality, and you will be able to charge your phone from anywhere without any physical contact at all.. Life may seem much more comfortable with all these things around us. But once gone, you might think that you never needed them at all. What do you think will be the result of such drastic changes? Share your thoughts with us in the comments below.. ...
中風微創手術, Endovascular therapy, 內血管治療, 腦內血管介入治療, 腦瘤, 腦血瘤, 大腦麻痺, 腦外科, 神經外科, 彭家雄, Pang Ka Hung, Peter Pang, 中風急救, 中風治療, Stroke, PCI, iv rtPA, 薄血藥, 腦血管支架, 腦血管狹窄, 預防中風, 中風風險評估, 黃金3小時, 黃金8小時
Buweno, sa ngalan ng aking kaharian at nang akin nasasakopan, gusto kong magpasalamat kay BINO. Maraming salamat parekoy, dahil binigyan mo ko ng isa pang dahilan para magpatuloy sa pagbablog, hehehe, itong mga nakaraan araw kasi parang natatamod na ako magblog, at dahil dito nagkaroon ako ng panibago at kakaibang enerhiya sa katawan upang ipagpatuloy ang mga pinaglalaban ko sa buhay, lalo na ang hangarin ng aking kaharian na gulohin ang matitino ninyong mga utak. MABUHAY ka BINO ...
Are you one of those moms like me, who panicked when the news about JE victims circulated online?. It was very alarming to hear this but the good news is wala tayong dapat ika-worry, dahil wala pang outbreak ng JE sa Pilipinas mga inays.. ...
Yang Zhao, Ming Zhang, Xinping Luo, Chongjian Wang, Linlin Li, Lu Zhang, Bingyuan Wang, Yongcheng Ren, Junmei Zhou, Chengyi Han, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Dongsheng Hu ...
Oncotarget | https://doi.org/10.18632/oncotarget.12922 Wei Shi, Yanxue Yin, Yao Wang, Bo Zhang, Pei Tan, Ting Jiang, Heng Mei, Jun Deng, Huafang Wang, Tao Guo, Zhiqing Pang, Yu Hu
Gamot para matagal labasan ang lalake - MGA PANALANGIN: GAYUMA ( pambabae at pang lalake). Ideal for treating acne spots directly.
Weeks total came out to a little under 81 miles, with a rolling 8-day total (Sunday-Sunday) of 103+ miles. The most important thing is that Im feeling healthy. Theres an errant ache here or a pang there, but nothing too concerning, and all part of what happens when pushing ones body (and mind) into uncharted training territory. However, Ive shuffled things around and am making this week a cutback week, with somewhere around 65 miles on tap. That was close to my peak week last year, so Im pleased with the progress Ive made ...
Hi All, Does anyone believe that by stopping smoking will help reduce the pangs of the tinnitus... Has anyone out there quit and has helped there...
Wang, Le; Wan, Zi Yi; Bai, Bin; Huang, Shu Qing; Chua, Elaine; Lee, May; Pang, Hong Yan; Wen, Yan Fei; Liu, Peng; Liu, Feng; Sun, Fei; Lin, Grace; Ye, Bao Qing; Yue, Gen Hua ...
The Ig-like domains of L1 can consider component in homophilic and heterophilic interactions ... condition models and human patients of Advertisement.
Ig Superfamily Molecules in the Nervous System автора Peter Sonderegger можно найти, купить на сайте ReadRate.com. На нашем сервисе вы найдете отзывы о книге.
... , Authors: Justyna Janik, Barbara Czarnocka. Published in: Atlas Genet Cytogenet Oncol Haematol.
TABLE-US-00004 TABLE 4 Cell and biological adhesion Fold Symbol Gene name Gene assignment change CLDN7 claudin 7 Involved in the formation of 2.74 tight junctions between epithelial cells PCDHB5 Protocadherin Member of the 3.32 beta-5 protocadherin beta gene cluster CLDN3 Claudin 3 Member of the claudin 3.93 family, is an integral membrane protein and a component of tight junction strands. CNTN6 contactin 6 Contactins mediate cell 3.09 surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. PKHD1 polycystic kidney Localized predominantly at 3.38 and hepatic the disease 1 apical domain of polarized epithelial cells, suggesting it may be involved in the tubulogenesis and/or maintenance of duct-lumen architecture. PCDHB2 protocadherin The extracellular domains 2.94 beta 2 interact in a homophilic manner to specify differential cell-cell connections. CDH1 E-cadherin cell adhesion molecule 3.27 (epithelial) CX3CL1 hemokine ...
Dr. Pang is a professor of optometry and the Assistant Dean for Research at the Illinois College of Optometry. Dr. Pang is active in both didactic teaching, including lecture and lab, and clinical teaching. Dr. Pang is an attending optometrist in the Pediatric and Binocular Vision service at the Illinois Eye Institute. Her research interests are in the areas of amblyopia, strabismus, and binocular vision function. Currently, she is the principal investigator for several NIH funded studies and other research projects. She has authored more than 110 peer reviewed publications and abstracts. In addition, Dr. Pang is in the editorial boards of four prestigious journals and is an active scientific referee for thirteen major journals. Dr. Pang is a fellow of the American Academy of Optometry and a diplomate of American Board of Optometry. ...
Contactin 1, Polyclonal, Invitrogen™ 100μL; Unconjugated Contactin 1, Polyclonal, Invitrogen™ Primary Antibodies Ci to Cx
Complete information for CNTN6 gene (Protein Coding), Contactin 6, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Complete information for CNTN2 gene (Protein Coding), Contactin 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
CNTN1 - CNTN1 (untagged)-ORIGENE UNIQUE VARIANT 1 of Human contactin 1 (CNTN1), available for purchase from OriGene - Your Gene Company.
The neurofibromatosis 2 (NF2) tumor suppressor protein merlin is commonly mutated in human benign brain tumors. The gene altered in NF2 was located on human chromosome 22q12 in 1993 and the encoded protein named merlin and schwannomin. Merlin has homology to ERM family proteins, ezrin, radixin, and moesin, within the protein 4.1 superfamily. In efforts to determine merlin function several groups have discovered 34 merlin interacting proteins, including ezrin, radixin, moesin, CD44, layilin, paxillin, actin, N-WASP, betaII-spectrin, microtubules, TRBP, eIF3c, PIKE, NHERF, MAP, RalGDS, RhoGDI, EG1/magicin, HEI10, HRS, syntenin, caspr/paranodin, DCC, NGB, CRM1/exportin, SCHIP1, MYPT-1-PP1delta, RIbeta, PKA, PAK (three types), calpain and Drosophila expanded ...
Our knowledge of enzyme-catalysed reactions has traditionally been gained from crystallography and solution studies. However, due to rapid developments in computer power and software, computational tools are playing an increasingly important role in obtaining an atomistic understanding of how enzymes achieve enormous rate accelerations.. The computational approaches can reveal aspects of a reaction that are difficult to access through experiment. Thus, combining the strength of the two can provide very detailed insight into enzyme catalysis, the knowledge of which could lead to the development of new drugs (most function as inhibitors of enzymes) and the design of efficient catalysts with many industrial applications.. Dr Pangs research aims at elucidating, from the quantum phenomenon to the macromolecular levels, fundamental mechanisms of enzyme activity. The current focus is to explore how protein dynamics - ranging from local atomic vibrations on a femto to picosecond time scale to larger ...
Invitation to the seminar by Dr. Paul Pang, the Decentralized Machine Learning Intelligence (DMLI) Laboratory/ Department of Computing, Faculty of Creative Industries and Business, Unitec Institute of Technology, New Zealand in the topic Incremental Linear Discriminant Analysis over Compressed Data Streams on Monday 29th October 2012 at 10.30 น. - 12.00, the meeting room 3/3, 3rd floor, SIT.. Please call 02-470-9850 for more information. ...
L1, also known as L1CAM, is a transmembrane protein; it is a neuronal cell adhesion molecule, member of the L1 protein family, of 200-220 kDa, and…
Mouse monoclonal antibody raised aginst synthetic peptide of Cntn1. A synthetic peptide corresponding to amino acids of 21-37 at extracellular domain of rat Cntn1. (MAB11957) - Products - Abnova
Rabbit polyclonal antibody raised against recombinant CNTN1. Recombinant protein corresponding to amino acids of human CNTN1. (PAB23744) - Products - Abnova
کانتکتین ۱ (انگلیسی: Contactin 1) یک پروتئین است که در انسان توسط ژن «CNTN۱» کُدگذاری می‌شود. پروتئینی که توسط این ژن ساخته می‌شود، در واقع، عضوی از اَبَرخانوادهٔ ایمنوگلوبولین‌هاست.[۲][۳] کانتکتین ۱، یک پروتئین غشاء عصبی متصل به گلیکوزیل‌فسفاتیدیل‌اینوزیتول است که در اتصال سلولی نقش دارد. احتمال دارد این پروتئین در تشکیل اتصالات آکسونی در جریان رشد و تکامل دستگاه عصبی نقش داشته باشد. دو گونه پیرایش آران‌ای مختلف برای این ژن یافت شده‌است که ایزوفرم‌های پروتئینی مختلفی را می‌سازند.[۳] ...
Drinking water, and lots of it, is always healthy and thats more than welcome!. Natural and safe to consume, one cannot have too much water. Matter of fact, its highly advisable for one to drink water as much as half of their weight in pounds.. Heres a little-known fact - dehydration often disguises itself as hunger pangs. And these hunger pangs often drive us rushing to the dining table. HOWEVER, its been proven that a glass of water is more than enough to ward off those hunger pangs…and that means you wont be tempted to eat unnecessarily.. And lets NOT forget about the cleansing effects of water, especially for your colon! Your colon, by the way, is usually filled with harmful substances and waste buildup. Getting rid of them means a cleaner colon that leads to a healthier and better-performing body.. ...
View mouse Cntnap4 Chr8:112570043-112882717 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
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See NAS NIV). Isaiah 21:3 Therefore are my loins filled with anguish; pangs have taken hold upon me, as the pangs of a woman in travail: I am pained so that I cannot hear; I am dismayed so that I cannot see ...
The death of actor Aloysius Pang (Pang) while serving his National Service duties caused me sadness and anger. Sadness over the loss of a young life full of unfulfilled potential and anger because of a seeming lack of accountability on the part of the government over these deaths. While inquiries are held when incidences such as these occur, they occur …. Read More » ...
Snacking is as important as any meal of the day. If you ever heard munching all day is not good. Read this to know how munching and snacking is healthful..
Kan, Lijuan; Grozhik, Anya V.; Vedanayagam, Jeffrey; Patil, Deepak P.; Pang, Nan; Huang, Yi-Chun; Joseph, Brian; Lin, Ching-Jung; Despic, Vladimir; Guo, Jian; Yan, Dong; Kondo, Shu; Deng, Wu-Min; Jaffrey, Samie R.; Lai, Eric C.; Lim, Kok Seong; Dedon, Peter C (Nature Publishing Group, 2017-07) ...