Genomic microarrays have been used as the first-tier cytogenetic diagnostic test for patients with developmental delay/intellectual disability, autism spectrum disorders and/or multiple congenital anomalies. The use of SNP arrays has revealed regions of homozygosity in the genome which can lead to identification of uniparental disomy and parental consanguinity in addition to copy number variations. Consanguinity is associated with an increased risk of birth defects and autosomal recessive disorders. However, the frequency of parental consanguinity in children with developmental disabilities is unknown, and consanguineous couples may not be identified during doctors visit or genetic counseling without microarray. We studied 607 proband pediatric patients referred for developmental disorders using a 4 × 180 K array containing both CGH and SNP probes. Using 720, 360, 180, and 90 Mb as the expected sizes of homozygosity for an estimated coefficient of inbreeding (F) 1/4, 1/8, 1/16, 1/32, parental
Periodontitis is defined as an inflammatory disease of supporting tissues of teeth characterized by progressive destruction of the periodontal ligament and alveolar bone. Periodontal manifestations of these genetic disorders or syndromes, such as familial and cyclic neutropenias, granulomatous disease, agranulocytosis, Langerhans cell disease, glycogen storage disease, hypophosphatasia, leucocyte adhesion deficiency, and Papillon‐Lefèvre, Chédiak‐Higashi, Cohen, Ehlers‐Danlos, Marfan, Down, Haim‐Munk, and Kindlers syndromes, imitate some types of periodontal diseases. Most of these syndromes have autosomal‐recessive characterization and can be seen commonly in consanguineous marriages. Therefore, consanguineous marriages have generally been accepted as having important detrimental effects on offspring. There is a lot of genetic research about consanguineous marriage and its detrimental effects on offspring. Although consanguineous marriages are common in the world, the relationship with
The basic issue here is that the Spanish Habsburgs tried to keep power by literally "keeping it in the family". During the last three-quarters of their time, from 1551 to 1700, no outsider married into the Spanish royal family. Indeed, if one looks at the six kings from 1497 (when Philip the Fair married Joanna I of Castile and Aragon, and thus became Philip I), then we note that there were 11 marriages, most of which were among blood relatives - two uncle-niece marriages, one double first cousin marriage, one first cousin marriage, two first cousins once removed marriages, one second cousin marriage, and two third cousin marriages. (See Wikipedia for an explanation of these relationship terms.) This gave Charles II an inbreeding coefficient of 0.254 (calculated by Alvarez et al. 2009) - for comparison, the offspring of a brother-sister union would have a value of 0.250, as would the offspring of a parent-child union. Phillip III (Charles IIs grandfather) also reached a high level: 0.218. Both ...
|b|This is further to my previous query regarding my marriage with my second cousin|/b|. I would like to know if a consanguineous marriage will always result in defective child? You had mentioned something about genetic disease in your reply. Can you tell me what that means? As far as the medical history is concerned, there have been no known diseases in our family that can be traced. You had also mentioned that there is 2 percent risk for defective children and this risk increases to 3 percent in the case of first cousins. Can you tell about this risk specifically in the case of second cousins?
In this ecological study, a robust negative correlation of r = − .62 (P less than .01) is reported between national IQs and consanguinity as measured by the log10 transformed percentage of consanguineous marriages for 72 countries. This correlation is reduced in magnitude, when IQ is controlled for GDP per capita (r = − .41, P less than .01); education index (r = − .40, P less than .01); and democracy index (r = − .42, P less than .01). Multiple regression analysis revealed that in the absence of the democracy index; percentage consanguineous marriages, education index and GDP per capita all exhibited stable final standardized β coefficients, however consanguinity had the least impact (β = 0, P greater than .05) whereas GDP per capita had the highest (β = .35, P greater than .01). This result is interpreted in light of cultural feedback theory, whereby it is suggested that consanguinity could subtly influence IQ at larger scales as a result of small IQ handicaps bought about through ...
Read Consanguinity in Context by Alan H. Bittles with Rakuten Kobo. An essential guide to this major contemporary issue, Consanguinity in Context is a uniquely comprehensive account of int...
In the Winter/Spring 2016 edition of ABA Criminal Justice Sections White Collar Crime Committee Newsletter, Kristofer Swanson and Rob Gardner discuss consanguinity and affinity and their significance in determining the outcome of a high profile lawsuit or whether a decision may withstand appeal. The article examines their applicability across various courts and the methods for assessing these relationship risks. For more information, click on the link below.
Along with consanguinity, assortative mating is an important characteristic of a population that can have a profound influence on the incidence of deafness. When a new recessive mutation first arises, there is a substantial risk that it will be lost by stochastic processes. Consanguinity helps ensure that at least some recessive mutations are expressed phenotypically where they can be exposed to positive or negative selection. Only after genes for deafness are expressed can assortative mating accelerate their increase in response to relaxed selection. Consanguinity, of course, affects all recessive genes indiscriminately, but the effect of assortative mating among the deaf is limited to genes for deafness, in which it preferentially increases the frequency of the commonest form of recessive deafness in a population.3 Acting together, these genetic mechanisms can thus promote the survival, expression, and spread of genes for deafness. The acquisition of either a traditional or an indigenous sign ...
Along with consanguinity, assortative mating is an important characteristic of a population that can have a profound influence on the incidence of deafness. When a new recessive mutation first arises, there is a substantial risk that it will be lost by stochastic processes. Consanguinity helps ensure that at least some recessive mutations are expressed phenotypically where they can be exposed to positive or negative selection. Only after genes for deafness are expressed can assortative mating accelerate their increase in response to relaxed selection. Consanguinity, of course, affects all recessive genes indiscriminately, but the effect of assortative mating among the deaf is limited to genes for deafness, in which it preferentially increases the frequency of the commonest form of recessive deafness in a population.3 Acting together, these genetic mechanisms can thus promote the survival, expression, and spread of genes for deafness. The acquisition of either a traditional or an indigenous sign ...
The consanguinity of parents (born in France) of individuals who have a recessive disease has been studied. The frequency of first cousin marriages is less than 0.2% in the general French population....
Malnutrition is currently a major problem around the world, especially in children aged less than 5 years. Lack of food and nutrients is not always the cause of malnutrition. Other important factors associated with malnutrition include insufficient knowledge of the mother, quality of childhood care, cultural and economic factors, childhood diseases, poverty, pollution, and an unhealthy environment (11). Childrens poor growth is one of the most important global health problems, especially in developing countries. Paying attention to this problem could result in colossal economic and social benefits and help promote the communitys health to a large extent (12).. Findings of this study showed that education level of the mother, mothers BMI before pregnancy, parental consanguinity, and feeding schedule were factors associated with FTT among children aged 3 to 72 months in Jahrom.. Results of this study showed that children, whose mothers had elementary education were 4.29 times more likely to ...
Delatycki MB; Laing N; Kirk E, 2019, Expanded reproductive carrier screening-how can we do the most good and cause the least harm?, European Journal of Human Genetics, vol. 27, pp. 669 - 670, http://dx.doi.org/10.1038/s41431-019-0356-y. Josephi-Taylor S; Barlow-Stewart K; Selvanathan A; Roscioli T; Bittles A; Meiser B; Worgan L; Rajagopalan S; Colley A; Kirk EP, 2019, User Acceptability of Whole Exome Reproductive Carrier Testing for Consanguineous Couples in Australia., J Genet Couns, vol. 28, pp. 240 - 250, http://dx.doi.org/10.1007/s10897-018-0298-5. Mason S; Castilla-Vallmanya L; James C; Andrews PI; Balcells S; Grinberg D; Kirk EP; Urreizti R, 2019, Case report of a child bearing a novel deleterious splicing variant in PIGT, Medicine, vol. 98, pp. e14524, http://dx.doi.org/10.1097/MD.0000000000014524. Palmer EE; Hong S; Al Zahrani F; Hashem MO; Aleisa FA; Ahmed HMJ; Kandula T; Macintosh R; Minoche AE; Puttick C, 2019, De Novo Variants Disrupting the HX Repeat Motif of ATN1 Cause a ...
Some of the explanation is under the picture but I just have to add my few words. I wish I knew for sure who the woman was sitting on the porch holding the two adorable little pudgy toddlers, but I dont. It might possibly be Daisie Catherine (Rush) Browning, the first wife of Roy Browning, my grandfather Virgils brother. If this is Daisie, she is holding Frederick Leroy Browning (b. 1928) and Esther Mae Browning (b. 1929) and would date the picture to around 1931 rather than the c1929 I have listed. Whoever the lady is, she is smiling a mile wide, though, isnt she? I also dont know the identities of the older boy to the left nor the older girl to the right with her finger to her lips looking puzzled. Shes clasping the hand of a smaller girl who is only half in the frame. I dont know who the smaller girl is either. I also like the wagon off in the distance ...
Today is December 7th and though this day is more popularly known as Pearl Harbor Day, it holds a more personal significance to me. Today was my grandfathers birthday. Virgil Joseph Browning died in 1989 but if he was still alive hed be 108 today. Two days from now, on December 9th, it will be my grandmothers birthday. The two always celebrated their special days together since they were so close (only 363 days apart, not counting leap years!) so today I will also remember my grandmother. Beulah Ethel (Garrard) Browning died in 2002 but if she were alive today she would be 109 ...
Synonyms for 5th cousin once removed in Free Thesaurus. Antonyms for 5th cousin once removed. 3 synonyms for cousin: cousin-german, first cousin, full cousin. What are synonyms for 5th cousin once removed?
Man is a social animal; therefore, he is dependent upon others for his social needs. The presence of viable social institutions is mandatory to groom the people into reasonable citizens having a balanced approach. In the contemporary world, fate of economic, religious, political and family institutions is ubiquitously in the doldrums. Therefore, the number of enlightened smut-hounds and moderate cool cats is continuously dwindling. The degraded social institutions indoctrinate erratic emotions that dominate personality of a wooly back and hothead pussyfooter. Thus tentacles of immoderations ensnare him permanently and squeeze him perpetually. Although, the crackpot man has made much progress but ironically all his progress is counter progress. Professor Jody precisely pointed towards the deterioration of humanity in these words, "Man has learned to fly in the air like birds and acquired the skill to swim in the water like fish but he failed to find out how to walk on the earth like ...
i guess that wasnt really my intention... i was looking more at the notion of being a youg person, and the changes that happen growing up, and my fascination that there could be any consistancy between the two given all the marvels and challenges in life. but i guess youre right -- perhaps a bad word for my intentions.... thank you ...
Abstract: This review includes for the first time a dynamical systems analysis of human quadrupedalism in Uner Tan syndrome, which is characterized by habitual quadrupedalism, impaired intelligence, and rudimentary speech. The first family was discovered in a small village near Iskenderun, and families were later found in Adana and two other small villages near Gaziantep and Canakkale. In all the affected individuals dynamic balance was impaired during upright walking,and they habitually preferred walking on all four extremities. MRI scans showed inferior cerebellovermian hypoplasia with slightly simplified cerebral gyri in three of the families, but appeared normal in the fourth. PET scans showed a decreased glucose metabolic activity in the cerebellum, vermis and, to a lesser extent the cerebral cortex, except for one patient, whose MRI scan also appeared to be normal. All four families had consanguineous marriages in their pedigrees, suggesting autosomal recessive transmission. The syndrome ...
Another cousin of Republic of Ireland striker Robbie Keane has died in a double tragedy after being overcome by fumes while working in a sewer.
A 5 month old girl born of non consanguineous marriage presented with cough and cold since 1½ months of age and breathlessness with suck-rest-suck cycle since 2½ months of age with gradual increase in symptoms.
Can anyone help me im with my cousin for 8 years and we really want a baby is it a good idea im just scared of anything happening
It was when I trawling through genealogy websites to see if I could get more information about my grandfathers family, who were small farmers in a townland called Derryronane in County Mayo, that the greatest surprise was uncovered. By this stage I knew hed fought in the Great War - my uncle Liam had given me the one artefact linking my grandfather to the British Army: his soldiers pay-book and wallet. But it wasnt until I visited the genealogy website, and came across a posting from a complete stranger who was also seeking information about the Derryronane McCanns, that I got the visual evidence. The stranger turned out to be my second cousin - a direct descendant of my grandfathers brother, John - and after we had exchanged emails he offered to send me various family photos.. When the email arrived with the PDF attachment, I casually scrolled through the old black and white photos of people who were vaguely familiar and others who were completely new to me. Then I came across one that ...
Build: Wed Jun 21 18:33:50 EDT 2017 (commit: 4a3b2dc). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
The Middle Ages was not strong on membership of communities. They were not obsessive about inside versus outside. They didnt emphasize, "Im a denizen of this town, Im a citizen of this country, I belong in this nation, behind these frontiers." They saw themselves rather like Hobbits (Tolkien was a medievalist). Hobbits knew their relatives to the seventh degree: second cousins three times removed, and so on. In the Middle Ages people saw themselves as part of a network of connections. They knew their family trees. They knew with whom they were related. They identified themselves as a node in a network and they saw pathways, connections to other people in their extended family. They also saw themselves in terms depending on their profession. If they were in the Church, they saw themselves in the Church hierarchy as being a priest here, subject to the archdeacon here, subject to the bishop there, and the archbishop and the pope. You could have status by being the servant to a servant to someone ...
The Middle Ages was not strong on membership of communities. They were not obsessive about inside versus outside. They didnt emphasize, "Im a denizen of this town, Im a citizen of this country, I belong in this nation, behind these frontiers." They saw themselves rather like Hobbits (Tolkien was a medievalist). Hobbits knew their relatives to the seventh degree: second cousins three times removed, and so on. In the Middle Ages people saw themselves as part of a network of connections. They knew their family trees. They knew with whom they were related. They identified themselves as a node in a network and they saw pathways, connections to other people in their extended family. They also saw themselves in terms depending on their profession. If they were in the Church, they saw themselves in the Church hierarchy as being a priest here, subject to the archdeacon here, subject to the bishop there, and the archbishop and the pope. You could have status by being the servant to a servant to someone ...
The Middle Ages was not strong on membership of communities. They were not obsessive about inside versus outside. They didnt emphasize, "Im a denizen of this town, Im a citizen of this country, I belong in this nation, behind these frontiers." They saw themselves rather like Hobbits (Tolkien was a medievalist). Hobbits knew their relatives to the seventh degree: second cousins three times removed, and so on. In the Middle Ages people saw themselves as part of a network of connections. They knew their family trees. They knew with whom they were related. They identified themselves as a node in a network and they saw pathways, connections to other people in their extended family. They also saw themselves in terms depending on their profession. If they were in the Church, they saw themselves in the Church hierarchy as being a priest here, subject to the archdeacon here, subject to the bishop there, and the archbishop and the pope. You could have status by being the servant to a servant to someone ...
Cleaning up after yourself was never so fun... Zeds got a big mess to clean up, thanks to his second cousin Zorp, and he needs your help. It goes like this: Magnetos are large, heavy spheres that power and control spaceships, and theyre normally suspended above all decks. But Zorp pulled the wrong lever (hes new) and now theyre all over the place! Zed has to get to the core of each spaceship to replace the fuse, and without power to the lift, he has to walk. Each deck ...
Hi There, Can i marry my own 2nd cousin. This the history of our background. My grandpa and her grandma are siblings. My dad and her dad are 1st cousin. And we have been together for more than 3 yea...
DEAR AMY: During the holidays, our cousins invited my brother, sister and me (along with our spouses and families) to her home for dinner. My cousin is compiling a family tree to document our heritage
As the NFL world continues to ask why the Redskins drafted quarterback Kirk Cousins in the fourth round after drafting quarterback Robert Griffin III second overall, Redskins quarterbacks coach Matt LaFleur says the answer to that question is simple: Cousins is just too good a player to pass up.
Guess who just dropped off a box of opks at my house? DHs crazy cousin thats who. DH called to tell me that she stopped by because shes working at the school up the street from us today. Apparently, she left a sticky note on the opk box with a good luck message and a smiley face.
ASHBURN, Va. - Washington quarterback Kirk Cousins says he literally tunes out critics who suggest his starting job is on the line.
Dear Amy: Every fall, my sister, cousins and a cousins sister-in-law have a weekend shopping excursion in our home city.. We stay in a hotel, treat ourselves, shop for our children and go out for meals. It is a great time to reconnect.. I have a sister "Wendy," whom we do not invite. She is offended to the point of tears when she finds we have not invited her. My two sisters and I are very close in age, but Wendy hasnt been as close to this set of cousins as my sister and I have been through the years.. We are all married stay-at-home moms. Wendy is a divorced, working mom with one young child.. There are several reasons we do not include her. We know she doesnt have very much money for such an outing. She also does not have many of the same interests as we do. Her life is quite different from ours. Were not interested in what she has to talk about. She complains too much about her aches and pains, and claims to have some kind of neurological disease that some of us feel is more ...
my cousin unfriended me. actually 2 of them-brother and sister. they are friends with my sister and other cousins but i think they may think that i wi
But thats not all. Married for the first time about a year and a half ago, I went to her wedding back east. She just completed her first (and now onl
It happened... is it wrong... we was talking one evening, she had been drinking and she started getting frisky and the next thing I know she was rubbing tits all over me and one thing led to another and when she felt me getting aroused she whispers how hot I make her and well, you all can imagine what happened next ...
I have a cousin i used to be very close to. We were supportive of each other growing up. Over the past three years, she has been very cruel to me. She makes a a...
Национальная медицинская академия последипломного образования имени П.Л. Шупика, г. Киев Изменения в патогенезе миомы матки, а именно - дополнение существующих теорий уменьшением количества родов у современных женщин и избыточным количеством менструаций, позволяют кроме гормональных методов лечения миомы матки довольно эффективно применять селективные модуляторы рецепторов прогестерона. Ключевые слова: лейомиома матки, консервативное лечение, селективные модуляторы рецепторов прогестерона. Литература: 1. Day Baird D, Dunson DB, Hill MC, Cousins D, Schectman JM. High ...
Introduction: Consanguineous marriage is associated with increased risks for congenital anomalies, low birthweight, and other adverse perinatal outcomes. In this population-based, case-control study we investigated the association between consanguineous marriage (first-cousin marriage) and stillbirth risk, using prospectively collected information from prepregnancy visits.. Material and methods: From 2007 to 2009, we identified 283 stillbirths (cases) and 2088 randomly selected live control births through prepregnancy visits in rural Golestan, Iran. The associations between consanguinity and prepregnancy maternal characteristics and stillbirth risk were examined using multivariate logistic regression.. Results: The rate of consanguineous marriage was 19.4% among cases and 13.6% among controls. Consanguinity was associated with increased stillbirth risk [ odds ratio (OR) 1.53; 95% CI 1.10-2.14]. The association was significantly increased for preterm stillbirth (, 37 gestational weeks) (OR 2.43; ...
Consanguineous marriage is matrimony between individuals who are closely related. Though it may involve incest, it implies more than the sexual nature of incest. In a clinical sense, marriage between two family members who are second cousins or closer qualify as having a consanguineous marriage. This is based on the gene copies their offspring may receive. Though these unions are still prevalent in some communities, as seen across the Greater Middle East region, many other populations have seen a great decline in family marriages. Globally, 8.5% of children have consanguineous parents, and 20% of the human population live in communities practicing endogamy. Theories on the developments of consanguineous marriage as a taboo can be supported as being both a social, and a biological development. In a social perspective, the observed inclination to practice consanguinity has been due to advantages to social and financial status. Upholding familial structure and assets, and ease of marital ...
Identifying genetic variants that lead to discernible phenotypes is the core of Mendelian genetics. An approach that considers embryonic lethality as a bona fide Mendelian phenotype has the potential to reveal novel genetic causes, which will further our understanding of early human development at a molecular level. Consanguineous families in which embryonic lethality segregates as a recessive Mendelian phenotype offer a unique opportunity for high throughput novel gene discovery as has been established for other recessive postnatal phenotypes. We have studied 24 eligible families using autozygosity mapping and whole-exome sequencing. In addition to revealing mutations in genes previously linked to embryonic lethality in severe cases, our approach revealed seven novel candidate genes (THSD1, PIGC, UBN1, MYOM1, DNAH14, GALNT14, and FZD6). A founder mutation in one of these genes, THSD1, which has been linked to vascular permeability, accounted for embryonic lethality in three of the study families.
MTHFR C677T polymorphisms among the Ahirs and Jats of Haryana (India). Consanguinity and early mortality in the Muslim populations of India and Pakistan
We have reanalysed genome scan data for three important infectious diseases: tuberculosis (TB) in The Gambia (Bellamy et al. 2000); leprosy in India (Siddiqui et al. 2001); and persistent hepatitis B infection both in The Gambia and Italy (Frodsham 2000; Frodsham et al. 2006); these populations differing in their rates of cousin marriages from less than 1 per cent in Italy up to 43 per cent in India. All four studies were based on an affected sib-pair design, with unaffected parents acting as controls for two or more affected offspring. Sample sizes for these studies are as follows: TB in The Gambia comprising 272 autosomal markers genotyped across 263 individuals in 74 families containing 155 affected offspring, 25 affected parents, 19 unaffected offspring and 64 affected parents; hepatitis in Gambia comprising 276 autosomal markers genotyped across 280 individuals in 62 families containing 152 affected offspring, 22 affected parents, 42 unaffected offspring and 64 unaffected parents; leprosy ...
mapped in detail how the parts of a particular ABC transporter protein the maltose transporter work together to transport sugar into the bacterium E coli She made what is perhaps her most important contribution so far by revealing the complete cycle of the maltose transporter protein which scientists use as a model to study other members of the ABC family The maltose transporter works by bringing a sugar known as maltose into bacterial cells and converting it into ATP which in turn powers the transporter Using a technique known as X ray crystallography Chen and her colleagues explored the protein s structure down to the atomic level and devised a way to capture the transporter in mid action Jue s research has thrown light onto the operation of ubiquitous cellular machines that transport key molecules into and out of cells and her ongoing work will have many important implications for human health says Rockefeller president Marc Tessier Lavigne It is my pleasure to welcome her to the Rockefeller ...
Dear Sandra This is a slightly tricky question, but I hope you will be able to follow my argument. Im not exactly sure I know what you mean by double first cousins. I think you mean that A and B are sibs, and C and D are sibs from an unrelated family, and A has offspring with C while B has offspring with D. Sibs, as I am sure you know, are related by 0.5. That is, there is a 0.5 probability of a particular gene being present (by descent) in two sibs that share the same mother and father. If E and F are double first cousins, the first thing to state is that they cannot be inbred. That is, they do not share any copies of the same gene (more correctly the same allele) that are identical by descent. That means we can use the same approach to relatedness as we do in the case of sibs. Take a random gene in E, and ask what is the probability that F has a copy of it? The answer is that it came from one parent (doesnt matter which). There is thus half a chance that it is also in that parents sib, and ...
Absolutely not.. The amount of saliva is a factor in whether or not you get DNA results at all. If you have them, thats it. While there is such a thing as "partial results" its because you need multiple passes of the DNA sequence to make sure there arent errors. No testing company will give you results if they dont get enough passes. A very small amount of saliva (like if theyre taking it from a 50 year old sealed envelope) might have this problem. If you dont have enough saliva for a proper test at a basic genetic genealogy company, they ask you to repeat the test.. In your case, Im afraid the answer is...you arent first cousins.. The expected range for first cousins is 553-1225 cM.. One strong possibility is that you are half first cousins, as the range for that is 137-856. There are many other possible relationships with 279 cM, but the others are less likely to be passed off as full first cousin.. ...
The human genome is characterised by many runs of homozygous genotypes, where identical haplotypes were inherited from each parent. The length of each run is determined partly by the number of generations since the common ancestor: offspring of cousin marriages have long runs of homozygosity (ROH), while the numerous shorter tracts relate to shared ancestry tens and hundreds of generations ago. Human populations have experienced a wide range of demographic histories and hold diverse cultural attitudes to consanguinity. In a global population dataset, genome-wide analysis of long and shorter ROH allows categorisation of the mainly indigenous populations sampled here into four major groups in which the majority of the population are inferred to have: (a) recent parental relatedness (south and west Asians); (b) shared parental ancestry arising hundreds to thousands of years ago through long term isolation and restricted effective population size (Ne), but little recent inbreeding (Oceanians); (c) ...
The On-line Journal of Genetics and Genealogy will highlight the connections between the science of Y and X chromosome, mitochondrial, and autosomal DNA analysis and genealogy. Reference will be made to scientific and genealogy articles which complement each other and advance the study of recent family history and ancient human migrations.. ...
View Notes - probset12 from L 311 at Indiana State University. 4.0kb 3.5kb Problem Set 12, Fall 2010 Name: 8 points total 2.5kb 1. A rare autosomal recessive disorder causes pink hair. A non-carrier
PEORIA - Lost in Bradleys 72-61 Wednesday night victory over Indiana State was another individual milestone for BU senior guard Nate Kennell.The Metamora native, who reached 1,000 career points last month and now ranks 36th on the BU career scoring list with 1,131, made a trio of 3-pointers to tie his first cousin and fellow Metamoran, Aaron Zobrist, for second on the all-time list for converted shots beyond the arc.Kennell and Zobrist both have 233 3-pointers, 29 behind all-time