C5a / C5a des Arg antibody [2942] (complement component 5) for IA, WB. Anti-C5a / C5a des Arg mAb (GTX11877) is tested in Human samples. 100% Ab-Assurance.
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Using polyacrylamide-gel isoelectric focusing followed by immunoblotting, genetic polymorphism of plasma vitamin D-binding protein (Gc) was examined in Asian sheep. The Gc polymorphism was revealed in the Khalkhas sheep of Mongolia, consisting of F, S and W variants, and the Yunnan native sheep of China, consisting of F and S variants. In particular, W was a new variant. The V variant detected in European sheep up to now was not observed in these sheep. The Bhyanglung, Baruwal, Kagi and Lampuchhre sheep of Nepal and local sheep of Bangladesh and Vietnam were monomorphic for the S variant. Family data and population genetic data supported the hypothesis that these variants were controlled by codominant alleles. In these Asian sheep, distribution of the |TEX|$Gc^s$|/TEX| allele was predominant (0.9571-1) and was seen as well in European sheep (Suffolk, Corriedale, Cheviot and Finnish Landrace) raised in Japan. |TEX|$Gc^w$|/TEX| allele was detected only in the Khalkhas sheep with the low frequency of 0
SWISS-MODEL Template Library (SMTL) entry for 1kxp.1. CRYSTAL STRUCTURE OF HUMAN VITAMIN D-BINDING PROTEIN IN COMPLEX WITH SKELETAL ACTIN
title: Relationship between vitamin D-binding protein polymorphisms and blood vitamin D level in Korean patients with COPD., doi: 10.2147/COPD.S96985, category: Article
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The discovery of biologically impactful and personalized melanoma prognostic markers complementing currently established, yet clinically less specific, histopathologic indicators is one of the key objectives of current melanoma research. Recent studies suggest that germline genetic variants may modulate cutaneous melanoma clinical endpoints, thereby representing potentially personalized and easily accessible prognostic biomarkers (7-12). However, while the majority of currently published studies on germline associations with prognosis still require independent validation in larger cohorts, the biologic and functional uncertainty of most prognostic variants further limits their clinical consideration. With the exception of few melanoma etiology related SNPs [e.g., MC1R (9), vitamin D-binding protein (11)], in general, almost exclusively, the genetic variants identified to date for associations with melanoma risk (i.e., GWAS loci) or prognosis (reviewed in ref. 8), map to noncoding regions with ...
TY - JOUR. T1 - Genetic variation in the Vitamin D Receptor (VDR) and the vitamin D-binding protein (GC) and risk for colorectal cancer. T2 - Results from the colon cancer family registry. AU - Poynter, Jenny N.. AU - Jacobs, Elizabeth T.. AU - Figueiredo, Jane C.. AU - Lee, Won H.. AU - Conti, David V.. AU - Campbell, Peter T.. AU - Levine, A. Joan. AU - Limburg, Paul. AU - Le Marchand, Loic. AU - Cotterchio, Michelle. AU - Newcomb, Polly A.. AU - Potter, John D.. AU - Jenkins, Mark A.. AU - Hopper, John L.. AU - Duggan, David J.. AU - Baron, John A.. AU - Haile, Robert W.. PY - 2010/2. Y1 - 2010/2. N2 - Epidemiologic evidence supports a role for vitamin D in colorectal cancer (CRC) risk. Variants in vitamin D-related genes might modify the association between vitamin D levels and CRC risk. In this analysis, we did a comprehensive evaluation of common variants in the vitamin D receptor (VDR) and the vitamin D-binding protein (GC; group-specific component) genes using a population-based ...
TY - JOUR. T1 - Critically ill children have low Vitamin D-binding protein, influencing bioavailability of Vitamin D. AU - Madden, Kate. AU - Feldman, Henry A.. AU - Chun, Rene F.. AU - Smith, Ellen M.. AU - Sullivan, Ryan M.. AU - Agan, Anna A.. AU - Keisling, Shannon M.. AU - Panoskaltsis-Mortari, Angela. AU - Randolph, Adrienne G.. PY - 2015/11. Y1 - 2015/11. N2 - Rationale: Vitamin D deficiency, often defined by total serum 25-hydroxyvitamin D (25[OH]D) ,20 ng/ml, is common in critically ill patients, with associations with increasedmortality andmorbidity in the intensive care unit. Correction of vitamin D deficiency in critical illness has been recommended, and ongoing clinical trials are investigating the effect of repletion on patient outcome. The biologically active amount of 25(OH)D depends on the concentration and protein isoformof vitamin D-binding protein (VDBP), which is also an acutephase reactant affected by inflammation and injury. Objectives: We performed a secondary analysis of ...
Relationship between vitamin D-binding protein polymorphisms and blood vitamin D level in Korean patients with COPD Youngmok Park,1 Young Sam Kim,1 Young Ae Kang,1 Ju Hye Shin,1 Yeon Mok Oh,2 Joon Beom Seo,3 Ji Ye Jung,1 Sang Do Lee2 On behalf of the KOLD study 1Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Institute of Chest Diseases, Yonsei University College of Medicine, 2Department of Pulmonary and Critical Care Medicine, Clinical Research Center for Chronic Obstructive Airway Diseases, 3Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea Background: In chronic obstructive pulmonary disease (COPD), the blood vitamin D3 level is generally low, and genetic polymorphisms of vitamin D-binding protein encoded by the GC gene are associated with COPD development. In this study, we examined the relationship between GC polymorphisms and plasma vitamin D3 level in Korean patients
1 reviews. Compare Complement C5a desArg ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.
استاندارد رمزنگاری داده (DES) یك الگوریتمی ریاضی است كه برای رمزنگاری و رمزگشایی اطلاعات كدشده باینری به كار می رود. رمزنگاری داده ها را تبدیل به داده...
The objectives are to define the complete structure of the human receptor for complement fragments C3b/C4b and its functional role in immune and inflammatory re...
1 reviews. Compare Anti-killer cell lectin like receptor C2 Antibody Products from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.
APD350Hu01, Active Interleukin 17 Receptor C (IL17RC), Homo sapiens (Human), Active protein, IL17-RL, IL17R-C, IL17Rhom, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14, Designed by Cloud-Clone Corp.
An emerging hypothesis suggests that vitamin D metabolites suppress the development of prostate cancer. In a recent epidemiological study, elevated levels of 1,25-dihydroxyvitamin D (1,25-D) in blood were associated with a greatly reduced risk, particularly in older men. We conducted a nested case-control study to evaluate the relationship between plasma levels of the two major vitamin D metabolites, 1,25-D and 25-hydroxyvitamin D (25-D), and subsequent diagnosis of prostate cancer. We also measured vitamin D-binding protein to investigate the influence of free metabolite levels on risk. Plasma samples from 14,916 participants in the Physicians Health Study were collected and frozen in 1982-1983. This analysis included 232 cases diagnosed up to 1992 and 414 age-matched control participants. Vitamin D metabolite and vitamin D-binding protein assays were conducted without knowledge of case-control status. Median levels of 25-D, 1,25-D, and vitamin D-binding protein were indistinguishable between ...
1869 Highly activated macrophages are tumoricidal. Inflammation-derived macrophage activation is the principal macrophage activation process that requires serum vitamin D-binding protein (known as Gc protein) and participation of B and T lymphocytes. A trisaccharide composed of N-acetylgalactosamine with dibranched galactose and sialic acid termini at 420 threonine residue of Gc protein is hydrolyzed by the inducible ß-galactosidase (Bgl) of inflammation-primed B cells and the Neu-1 sialidase of T cells to yield the macrophage activating factor (MAF). Thus, Gc protein is the precursor for the principal MAF. However, the MAF precursor activity of Gc protein of cancer patients was lost or reduced because Gc protein is deglycosylated by serum α-N-acetylgalactosaminidase (Nagalase) secreted from cancerous cells but not from healthy cells. Thus, serum Nagalase activity is proportional to tumor burden and serves as a prognostic index. Exogenously given macrophage activating factor can bypass ...
Analyse bioinformatique des événements de transferts horizontaux entre espèces de drosophiles et lien avec la régulation des éléments transposables ...
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Dr. Hirsch has been a longtime friend and supporter in numerous ways of the String Academy. He served on the SAW Board of Directors for many years and was also a collaborative sonata pianist for students at the school. The award has been presented annually since 1991 by the String Academy to an outstanding individual who has made a significant contribution to the Milwaukee arts community.. Erwin was born in Austria in 1920. After studying in Oxford, England, he came to the U.S. where he joined his parents and sister in Boston. He graduated from Harvard College in 1942 and from Harvard Medical School in 1946. Pursuing hematology research, he devised a method that for the first time successfully transfused blood platelets, today a routine procedure. Dr. Hirsch was called into the Army Medical Corps to serve during the Korean War from 1952-1954. After eight years of private practice in Providence, RI, he followed his increasing interest in medical education at Princeton Hospital in NJ. Called to ...
TY - JOUR. T1 - An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2. AU - Gerard, Norma P.. AU - Lu, Bao. AU - Liu, Pixu. AU - Craig, Stewart. AU - Fujiwara, Yuko. AU - Okinaga, Shoji. AU - Gerard, Craig. PY - 2005/12/2. Y1 - 2005/12/2. N2 - C5L2 is an enigmatic serpentine receptor that is co-expressed with the C5a receptor on many cells including polymorphonuclear neutrophils. The apparent absence of coupling of C5L2 with G proteins suggests that this receptor may modulate the biological activity of C5a, perhaps by acting as a decoy receptor. Alternatively, C5L2 may affect C5a function through formation of a heteromeric complex with the C5aR, or it may utilize a G protein-independent signaling pathway. Here we show that in mice bearing a targeted deletion of C5L2, the biological activity of C5a/C5adesArg is enhanced both in vivo and in vitro. The biological role of C5L2 thus appears to be limiting to the pro-inflammatory response to the anaphylatoxin. ...
Now, they may soon add a new risk factor to the list: activation of the complement system. The complement system is usually implicated in immune responses, but now theres a role for it in cardiovascular disease. In a new research report appearing in the January 2011 print issue of the FASEB Journal (http://www.fasebj.org), scientists from Europe and the United States show that anaphylatoxin C5a, a protein released when complement is activated, contributes to atherosclerotic disease. C5a causes plaques to break free from where they would be anchored to ultimately cause blockages elsewhere in the body. This new discovery not only shows that C5a is a new marker for identifying risk for heart attack and stroke, but it also establishes C5a as a new therapeutic target for preventing these problems.. Given the huge impact of cardiovascular disease in general, and atherosclerosis in particular, on public health, we feel that unraveling mechanisms involved in the development and progression of the ...
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Bachem offers H-6322 C5a Anaphylatoxin (human) for your research. Find all specific details here. Find product specific information including available pack sizes, CAS, detailed description and references here.
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Archives de pédiatrie - Vol. 14 - N° 3 - p. 239-243 - Distribution des sérotypes de pneumocoques responsables des pleuropneumopathies de lenfant en France - EM|consulte
Die Sedimentationskonstante S20.w° des Kartoffelvirus M (KVM) beträgt 167±1 S. Die Konzentrationsabhängigkeit ergibt sich aus der Beziehung s20.wc=(167−33×c) S. Die Schwebedichte des KVM in...
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Black Americans had lower levels of total 25-hydroxyvitamin D and vitamin D-binding protein than whites, but similar levels of bioavailable 25-hydroxyvitamin D, and higher bone density.
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The normal range of human serum albumin in adults (, 3 y.o.) is 3.5 to 5 g/dL. For children less than three years of age, the normal range is broader, 2.9-5.5 g/dL.[9] Low albumin (hypoalbuminemia) may be caused by liver disease, nephrotic syndrome, burns, protein-losing enteropathy, malabsorption, malnutrition, late pregnancy, artefact, genetic variations and malignancy. High albumin (hyperalbuminemia) is almost always caused by dehydration. In some cases of retinol (Vitamin A) deficiency, the albumin level can be elevated to high-normal values (e.g., 4.9 g/dL). This is because retinol causes cells to swell with water (this is also the reason too much Vitamin A is toxic).[10] This swelling also likely occurs during treatment with 13-cis retinoic acid (isotretnoin), a pharmaceutical for treating severe acne, amongst other conditions. In lab experiments it has been shown that all-trans retinoic acid down regulates human albumin production.[11] ...
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Rahier, Jacques ; Guiot, Yves ; Sempoux, Christine. Diabète de type 2 et déficit des cellules B.. In: Journées annuelles de diabétologie de lHôtel-Dieu, , p. 19-27 (2004 ...
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