1. The a- and b-chains of reduced and alkylated human complement subcomponent C1r were separated by high-pressure gel-permeation chromatography and isolated in good yield and in pure form. 2. CNBr cleavage of C1r b-chain yielded eight major peptides, which were purified by gel filtration and high-pressure reversed-phase chromatography. As determined from the sum of their amino acid compositions, these peptides accounted for a minimum molecular weight of 28 000, close to the value 29 100 calculated from the whole b-chain. 3. N-Terminal sequence determinations of C1r b-chain and its CNBr-cleavage peptides allowed the identification of about two-thirds of the amino acids of C1r b-chain. From our results, and on the basis of homology with other serine proteinases, an alignment of the eight CNBr-cleavage peptides from C1r b-chain is proposed. 4. The residues forming the charge-relay system of the active site of serine proteinases (His-57, Asp-102 and Ser-195 in the chymotrypsinogen numbering) are ...

Complement component 1 Q subcomponent-binding protein, mitochondrial is a protein that in humans is encoded by the C1QBP gene.[5][6][7] The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein.[7] ...

Recombinant Complement Component 1, R Subcomponent A (C1RA) Protein (His tag). Species: Mouse (Murine). Source: Insect Cells. Order product ABIN3125986.

The subcomponents C1r and C1s and their activated forms C-1r and C-1s were each found to have mol.wts. in dissociating solvents of about 83000. The amino acid compositions of each were similar, but there were significant differences in the monosaccharide analyses of subcomponents C1r and C1s, whether activated or not. Subcomponents C1r and C1s have only one polypeptide chain, but subcomponents C-1r and C-1s each contain two peptide chains of approx. mol.wts. 56000 (a chain) and 27000 (b chain). The amino acid analyses of the a chains from each activated subcomponent are similar, as are those of the b chains. The N-terminal amino acid sequence of 29 residues of the C-1s a chain was determined, but the C-1r a chain has blocked N-terminal amino acid. The 20 N-terminal residues of both b chains are similar, but not identical, and both show obvious homology with other serine proteinases. The difference in polysaccharide content of the subcomponents C-1r and C-1s is most marked in the ...

Several of the above proteins consist of a catalytic domain together with several CUB domains interspersed by calcium-binding EGF domains. Some CUB domains appear to be involved in oligomerisation and/or recognition of substrates and binding partners. For example, in the complement proteases, the CUB domains mediate dimerisation and binding to collagen-like regions of target proteins (e.g. C1q for C1r/C1s). The structure of CUB domains consists of a beta-sandwich with a jelly-roll fold. Almost all CUB domains contain four conserved cysteines that probably form two disulphide bridges (C1-C2, C3-C4). The CUB1 domains of C1s and Map19 have calcium-binding sites [ (PUBMED:17446170) ]. ...

Several of the above proteins consist of a catalytic domain together with several CUB domains interspersed by calcium-binding EGF domains. Some CUB domains appear to be involved in oligomerisation and/or recognition of substrates and binding partners. For example, in the complement proteases, the CUB domains mediate dimerisation and binding to collagen-like regions of target proteins (e.g. C1q for C1r/C1s). The structure of CUB domains consists of a beta-sandwich with a jelly-roll fold. Almost all CUB domains contain four conserved cysteines that probably form two disulphide bridges (C1-C2, C3-C4). The CUB1 domains of C1s and Map19 have calcium-binding sites [(PUBMED:17446170)].. ...

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Originally Posted by dmatter I took about 10 Years off to Race Dirt Bikes, Separated My shoulders, Broke My Collar Bone, Broke my femur, Bruised about

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does this sound right to anyone with JAMMIN/PICCO experience...??? tore down my JAMMIN .28 after a successful race season. found that the pistons

Such are the petty games and I am glad I kept out of the fray not interfering in this at all and lets, time take its course. The old lady had commented on my lack of interest in the matter by not going to her house to ask her to return! I was not party to the incident so why should I interfere, and she is welcome to withhold her employment, and I will be the beneficiary not having to deal with personal vendettas.I only want performance for just pay, and I will not interfere in their lives.I am sure I have not seen the end of this as I am sure this lady who has been at the farm for over 25 years will try her best to get this girl off the place, and will try to influence my father, in the matter.It will be interesting to see the next move, and what sordid story will be cooked up to achieve this end. In the meantime I am trying to write a skit for a comedy, based completely on this story as I only see the comedy unfolding in this otherwise tragic case. Their is a lot more to this story with this ...

Such are the petty games and I am glad I kept out of the fray not interfering in this at all and lets, time take its course. The old lady had commented on my lack of interest in the matter by not going to her house to ask her to return! I was not party to the incident so why should I interfere, and she is welcome to withhold her employment, and I will be the beneficiary not having to deal with personal vendettas.I only want performance for just pay, and I will not interfere in their lives.I am sure I have not seen the end of this as I am sure this lady who has been at the farm for over 25 years will try her best to get this girl off the place, and will try to influence my father, in the matter.It will be interesting to see the next move, and what sordid story will be cooked up to achieve this end. In the meantime I am trying to write a skit for a comedy, based completely on this story as I only see the comedy unfolding in this otherwise tragic case. Their is a lot more to this story with this ...

Bu t r yap t r c lar, UV veya g r n r a maruz kald klar nda k sa s rede k rle irler. K rle me h z n iddetine ve dalga boyuna ba l d r. I n yap t r c tabakas na ula abilmesi i in, yap t r lan par alardan en az birinin k ge iren bir malzeme olmas gereklidir. Bu nedenle cam ve effaf plastik t r malzemelerin yap t r lmas nda tercih edilirler.. zel r nler ...

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The temptation for Kyosho to recreate the same high performance and style of a true AWD (all-wheel-drive) in Mini-Z size was simply too much to resist. The advanced design combines a shaft driven AWD with a precision 4-wheel independent suspension using a

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This is directed mostly to Foodie. I tried to e-mail him but it didnt go through. I really like Arlaud 99 Morey-St.-Denis Les Ruchots (a premier cru) and slightly behind that the Arlaud 99 Morey-St.-Denis Millandes (another premier cru). I also found Arlauds 99 Clos-St.-Denis (grand cru) very appealing and better than the 98 of the same wine. I was surprised that Serena Sutcliffe in a book on Burgundy wines made rather a snotty or snobbish and dismissive comment about Arlaud wines. I know several distributors and retailers who are enthusiastic about this producer and go to extra pains to acquaint people with his wines because Morey-St.-Denis isnt as well known as its neighbors. (I actually prefer the Arlaud M-S-D wines to his Gevrey wines.) Foodie, do you have any experience with Arlauds 99 wines? What is your opinion of them? I may not have enough experience with red burgundies (although I keep trying to increase it)to know if his wines are faithful to terroir or corrupted by modern ...

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The MUC1 tumor associated antigen is highly expressed on a range of tumors. Its broad distribution on primary tumors and metastases renders it an attractive target for immunotherapy. After synthesis MUC1 is cleaved, yielding a large soluble extracellular alpha subunit containing the tandem repeats array (TRA) domain specifically bound, via non-covalent interaction, to a smaller beta subunit containing the transmembrane and cytoplasmic domains. Thus far, inconclusive efficacy has been reported for anti-MUC1 antibodies directed against the soluble alpha subunit. Targeting the cell bound beta subunit, may bypass limitations posed by circulating TRA domains. MUC1s signal peptide (SP) domain promiscuously binds multiple MHC class II and Class I alleles, which upon vaccination, generated robust T-cell immunity against MUC1-positive tumors. This is a first demonstration of non-MHC associated, MUC1 specific, cell surfaces presence for MUC1 SP domain. Polyclonal and monoclonal antibodies generated ...

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Mellors, R C., (slow) Virus infection, autoimmunity, and and lymphoma, an experimental model of human disease. (1969). Subject Strain Bibliography 1969. 1878 ...

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Guzman, R C.; Osborn, R C.; Yang, J; D; and Nandi, S, Transplantation of mouse mammary epithelial cells grown in primary collagen gel cultures. (1982). Subject Strain Bibliography 1982. 2450 ...

Gaisl, Thomas; Giunta, Cecilia; Bratton, Daniel J; Sutherland, Kate; Schlatzer, Christian; Sievi, Noriane; Franzen, Daniel; Cistulli, Peter A; Rohrbach, Marianne; Kohler, Malcolm (2017). Obstructive sleep apnoea and quality of life in Ehlers-Danlos syndrome: a parallel cohort study. Thorax, 72(8):729-735.. Kapferer-Seebacher, Ines; Pepin, Melanie; Werner, Roland; Aitman, Timothy J; Nordgren, Ann; Stoiber, Heribert; Thielens, Nicole; Gaboriaud, Christine; Amberger, Albert; Schossig, Anna; Gruber, Robert; Giunta, Cecilia; Bamshad, Michael; Björck, Erik; Chen, Christina; Chitayat, David; Dorschner, Michael; Schmitt-Egenolf, Marcus; Hale, Christopher J; Hanna, David; Hennies, Hans Christian; Heiss-Kisielewsky, Irene; Lindstrand, Anna; Lundberg, Pernilla; Mitchell, Anna L; Nickerson, Deborah A; Reinstein, Eyal; Rohrbach, Marianne; Romani, Nikolaus; Schmuth, Matthias; et al (2016). Periodontal Ehlers-Danlos syndrome is caused by mutations in C1R and C1S, which encode subcomponents C1r and C1s of ...

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by Brian Robinson, 9/27/98. I don t know if R C Lewontin s name features in the vast pool of knowledge above, but let me drop it in now to watch the ripples (even if the stone itself sinks!). You ll recall that quite some years ago he co-wrote a book, Not In Our Genes . It s a very long time since I read it but my feeling persists that it was not always easy to be sure what exactly the authors were saying (was it Bertrand Russell who said that you can never be sure exactly what you re saying until you know precisely what it is you are denying?). The general message, I think, was that it was quite wrong to look to genes to answer questions about human behaviour and intelligence. If that is a garbled account, please correct me, but it would seem extraordinary if genes were not to have a controlling influence on the brain when they exert so much control on every other organ in the body. But I ve just been reading his 1993 book, The Doctrine of DNA: Biology as ideology which, excepting one chapter, ...

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Shaft driven AWD with four-wheel independent suspension in Kyoshos micro-sized Mini-Z AWD realizes dynamic performance with an advanced new style. The aggressive design of the front spoiler combines with a mock carbon bonnet (decal finish), side steps, a

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GeneGene-level p-value [a] GS GS p-value MM MM p-valueRank [b] miRNA r [c] p-value FDR GPD1L 2.67E-02 −0.23 1.06E-03 0.90 1.29E-71 1 hsa-miR-210 −0.17 7.37E-03 7.91E-02 CCDC50 2.12E-02 −0.20 4.68E-03 0.85 6.79E-58 2 hsa-miR-501-3p −0.19 3.93E-03 5.05E-02 NAALAD2 8.05E-03 −0.24 5.76E-04 0.85 1.47E-57 3 hsa-miR-140-3p −0.29 1.97E-05 7.98E-04 ALDH1L1 4.94E-03 −0.28 7.13E-05 0.85 3.15E-57 4 hsa-miR-342-5p −0.27 5.13E-05 1. 76E-03 ADH1B 3.14E-02 −0.27 8.82E-05 0.85 4.39E-56 5 - - - - ADH1A 5.00E-02 −0.26 1.83E-04 0.82 2.34E-50 6 hsa-miR-590-3p −0.09 1.06E-01 4.46E-01 PCCA 2.38E-02 −0.21 2.68E-03 0.82 3.87E-49 8 hsa-miR-301b −0.25 2.08E-04 5.42E-03 ORMDL3 3.87E-03 −0.29 3.04E-05 0.80 3.29E-45 9 hsa-miR-362-3p −0.20 2.12E-03 3.23E-02EPB41L4B [d] 7.42E-05 −0.29 3. 47E-05 0.67 2.63E-27 28 has-miR-3613-3p −0.11 6.46E-02 3.4E-01GS, gene significance; MM, module membership. [score:1] ...

Y V Bogdanova, C J Owen, A N Fazakerley, R C Fear (MSSL), M G G T Taylor (ESTEC), M W Dunlop, J A Davies (RAL), A D Lahiff (MSSL), F Pitout (MPI), C M Carr (IC), H Laakso (ESTEC), Z Pu (Beijing), Q -G Zong (Boston), S E Milan (Leicester), C Shen (CSSAR), H Rème (CESR), and A Balogh (IC), Plasma layers around dayside subsolar magnetopause and inside the cusp region under northward IMF: conjugated Cluster and Double Star observations ...

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