TY - JOUR. T1 - Comparative effectiveness research in liver transplantation. T2 - Crossing the cost and quality chasm. AU - Jay, Colleen L.. AU - Skaro, Anton I. PY - 2013/1/1. Y1 - 2013/1/1. UR - http://www.scopus.com/inward/record.url?scp=84886944223&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84886944223&partnerID=8YFLogxK. U2 - 10.2217/cer.12.65. DO - 10.2217/cer.12.65. M3 - Review article. C2 - 24236515. AN - SCOPUS:84886944223. VL - 2. SP - 7. EP - 9. JO - Journal of Comparative Effectiveness Research. JF - Journal of Comparative Effectiveness Research. SN - 2042-6305. IS - 1. ER - ...
Comparative Effectiveness Research is an international, peer reviewed, open access journal that strives to cover this emerging field. Comparative effectiveness research (CER) is a PICOT (Population, Intervention, Comparison, Outcome, Time) question-driven, systematic process of investigation; it utilizes the well-characterized design of research synthesis, validated methodology for assessing the evidence and data analysis, which includes acceptable sampling and meta-analysis. CER assembles the best available evidence for ensuring effectiveness-focused, patient-centered and evidence-based medicine, dentistry, nursing and allied disciplines. CER is the critical and timely process of translational healthcare; it evinces the most reliable evidence to compare the advantages, disadvantages and expenditure for an intervention with other available options for the prevention, diagnosis, treatment and monitoring of a clinical condition. CER amalgamates patients, clinicians, caregivers and other stakeholders to
Abstract (from Health Affairs): Medicines current evidence base is insufficient for many of the decisions made daily by clinicians, patients, purchasers, and policy makers. The Patient-Centered Outcomes Research Institute (PCORI) represents an effort by the US government to address this shortcoming by funding comparative effectiveness research (CER). Prioritizing that research will be a critical first step. To better understand components of an optimal process, NPC reviewed the literature and conducted interviews regarding the prioritization efforts of leading public and private health organizations in the United States and abroad. From this review, NPC proposes a framework for prioritization, poses and answers key questions, and makes recommendations regarding application of that framework. NPC also recommends that during the priority-setting process, there should be transparent conversations among those who make decisions about the priorities and the public.. ...
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NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Recovery Act 2009 Limited Competition OS ARRA: Comparative Effectiveness Research to Optimize Prevention and Healthcare Management for the Complex Patient (R21) RFA-HS-10-009. AHRQ
The prevalence of obesity and diabetes in older adults is increasing. Because older adults are often portrayed as less likely to change long-standing health behaviors, health promotion in this age group has lagged behind others. In fact, little attention has been given to the importance of diabetes prevention in community-dwelling older adults through the implementation of programs that promote healthy nutrition, increase physical activity and improve self-management. The Diabetes Prevention Program (DPP), which demonstrated the benefit of modest weight loss on the reduction of diabetes risk (58% overall reduction with a 71% reduction in the older population), has yet to be translated into widespread public health practice.. The overall objective of this protocol is to implement evidence-informed, innovative interventions to increase adoption of findings from comparative effectiveness research (CER) for diabetes management and prevention in South Florida older veterans. Specifically, the ...
The main thrust of this con article is to state that the area of portable monitoring and home-based treatment of sleep apnea direly needs comparative effectiveness research (CER) with cost-efficacy and tangible patient outcomes measurements before widespread institution into real-world practice. In the absence of such CER, currently, there are few modeling studies that are not favorable toward portable monitoring and home-based treatment initiation, and that requires careful attention.16-18. Pietzche and colleagues recently published their Markov model-based study which used a hypothetical model applied to 50-year-old men with a 50% chance of having moderate-severe sleep apnea.17 They performed 10-year and lifetime incremental cost-effectiveness ratio projections for laboratory based studies and portable monitoring.17 They factored rates and cost of cardiovascular events and motor vehicle accidents, health-related quality of life, CPAP adherence, and failure of portable monitoring or therapy. ...
Agencies in Australia, France, Germany, and the U.K. have comparative effectiveness research agencies that offer lessons for the United States.
Dr. Steven Pearson, president of Institute for Clinical and Economic Review, explains how private and public payers might use comparative effectiveness research, particularly with the expected influx of new information from federal sources. NPC spoke with Dr. Pearson at the Drug Information Association Annual Meeting in June 2011.. ...
In the aftermath of the Supreme Courts landmark Affordable Care Act ruling, leading health care researchers will discuss strategies for analyzing large population databases to conduct comparative effectiveness research (CER) July 13 at Rice Universitys Baker Institute for Public Policy.
For all its costs, flaws, and inequities, American health care is fundamentally rooted in a belief that treatment should be based on solid scientific research. To this end, between 2003 and 2010, three different federal laws were enacted, the most recent being the Affordable Care Act of 2010, that mandated new federal investments in a type of clinical research called comparative effectiveness research (CER) - research into what works best in medical care.
Our work will include comparative effectiveness research, with an emphasis on causal inference methods for complex longitudinal data from both observational studies and randomized trials, e.g. to assess effects of interventions on cardiovascular disease, cancer, and others. The research will mainly be based on data from Swedish population and health data registers.
But the truth is: this trial never would have seen the light of day if it werent for industry. Note that St. Jude Medical paid $20 million and Biosense Webster paid $18 million toward the trial, while the government could only foot 35% ($18 million) of the costs for the trial. Some will consider this an efficient use of government funds. Others will point to the governments new paradigm for requiring significant industry sponsorship to fund their comparative effectiveness research (CER) trials as opening the potential for the development of pay to play relationships to develop between government and industry. One only has to look to the FDAs recent challenges at separating themselves from industry influence to see the potential for conflict ...
But the truth is: this trial never would have seen the light of day if it werent for industry. Note that St. Jude Medical paid $20 million and Biosense Webster paid $18 million toward the trial, while the government could only foot 35% ($18 million) of the costs for the trial. Some will consider this an efficient use of government funds. Others will point to the governments new paradigm for requiring significant industry sponsorship to fund their comparative effectiveness research (CER) trials as opening the potential for the development of pay to play relationships to develop between government and industry. One only has to look to the FDAs recent challenges at separating themselves from industry influence to see the potential for conflict ...
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Meystre S, Gouripeddi R, Tieder J, Simmons J, Srivastava R, Shah S. Enhancing Comparative Effectiveness Research With Automated Pediatric Pneumonia Detection in a Multi-Institutional Clinical Repository: A PHIS+ Pilot Study. J Med Internet Res. 2017 May 15;19(5):e162.. ...
Mood stabilizers, medications that prevent future mood episodes, are the foundation for treatment of bipolar disorder. While all published bipolar disorder treatment guidelines recommend that pharmacotherapy should include mood stabilizers for long-term maintenance treatment, no randomized comparative effectiveness studies have examined the real-world advantages and disadvantages of the newer second generation antipsychotic (SGA) mood stabilizers compared to the classic mood stabilizers, such as lithium (Li). No studies have looked at the effectiveness of SGAs compared to mood stabilizers when used in the context of other medications required to manage bipolar patients, since bipolar disorder patients take a median of 3 medications for optimal outcomes. Quetiapine (QTP) is the most extensively studied, broadly efficacious and the most widely prescribed SGA for bipolar disorder. The classic mood stabilizer Li has the largest evidence base for treating bipolar disorder, but has been largely ...
1) Comparative effectiveness research and 2) ACGME proposals for work duty hours. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Michael Benatar interviews Dr. Jacqueline French about her paper on comparative effectiveness research. In the next segment, Dr. Ryan Overman is reading our e-Pearl of the week about Guillain-Barré-like syndrome with thallium poisoning. In the next part of the podcast Dr. Ted Burns interviews Dr. Lori Schuh about ACGME recommendations for work duty hours for Read More 1) Comparative effectiveness research and 2) ACGME proposals for work duty hours. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Michael Benatar interviews Dr. Jacqueline French about her paper on ...
TY - JOUR. T1 - Comparative effectiveness review of treatment options for pituitary microadenomas in acromegaly. T2 - Clinical article. AU - Marko, Nicholas F.. AU - Lasota, Emily. AU - Hamrahian, Amir. AU - Weil, Robert J.. PY - 2012/9/1. Y1 - 2012/9/1. N2 - Object. Acromegaly, a syndrome of excess growth hormone (GH) secretion typically caused by a GH-secreting pituitary adenoma, reduces life expectancy by approximately 10 years when left untreated. Treatment of acromegaly involves combinations of one or more discrete therapeutic modalities to achieve biochemical control. Unfortunately, data capable of informing decisions among alternate management strategies are presently lacking. Methods. The authors performed a comparative effectiveness research (CER) review integrating efficacy, cost, and quality of life (QOL) analysis for treatment strategies comprising various combinations of surgery, radiotherapy, stereotactic radiosurgery, and pharmacotherapy in patients with acromegaly caused by a ...
Group Health has been approved for two research awards from the Patient-Centered Outcomes Research Institute (PCORI) to study ways to improve care for back pain and to connect patients with community resources. The projects are part of a portfolio of patient-centered comparative clinical effectiveness research that addresses PCORIs National Priorities for Research and Research Agenda.. ...
Under some all-powerful government CER panel would Clinton have received the stents? What does CER tell us about the best treatment for ACS? We have comparative effectiveness studies out the wazoo on this issue alone and they would be too numerous to mention here. For the most part these studies are compiled and evaluated in the latest ACC/AHA guidelines for unstable angina/NSTEMI, which is what Clinton most likely had. Under these guidelines either an initial conservative or invasive strategy is allowed, and if the patient stabilizes clinically a stress test is recommended before cardiac catheterization. Positive cardiac markers and ST segment or T wave changes suggest, but do not mandate, an initial invasive strategy under the guidelines. My summary is a gross oversimplification. Be assured the government will oversimplify even more. The Fox piece is distorted and non-informative but suffice it to say that in an era where government panels wrest EBM from the hands of physicians Clinton (or ...
Comparative Effectiveness Review Number 134 Pharmacotherapy for Adults With Alcohol- Use Disorders in Outpatient Settings Comparative Effectiveness Review Number 134 Pharmacotherapy for Adults With Alcohol-Use
The Patient-Centered Outcomes Research Institute (PCORI) is a United States-based non-governmental institute created as part of a modification to the Social Security Act by clauses in the Patient Protection and Affordable Care Act. It is a government-sponsored organization charged with investigating the relative effectiveness of various medical treatments. Medicare may consider the Institutes research in the determining what sorts of therapies it will cover. PCORI was established by the 2010 Patient Protection and Affordable Care Act. It is a 501(c)(1) organization. PCORI is charged with examining the relative health outcomes, clinical effectiveness, and appropriateness of different medical treatments by evaluating existing studies and conducting its own. Its nineteen-member board includes patients, physicians, nurses, hospitals, drug makers, device manufacturers, insurers, payers, government officials and health experts. It will not have the power to mandate or even endorse coverage rules or ...
1. Do you feel it is better to allow individuals the freedom to choose any type of (or no) health insurance coverage available to them or to increase government involvement in a persons/familys healthcare via mandates, such as the ACA and/or the government as a single insurer for all residents. Why?. 2. Discuss the mission of the Patient-Centered Outcomes Research Institute (PCORI) and the Center for Medicare & Medicaid Innovation (CMMI).. 3. If you could reform the malpractice or tort laws, what types of changes would you make? When do you feel it is appropriate for someone to claim damages from medical procedures or treatment? Do you feel there should be a cap on the payments, and if so, how would you decide what that cap would be? What are all the different costs involved in medical malpractice suites? Is it easier to talk about tort reform than to actually try to define it?. 4. The rights of people once they have been incarcerated can be a controversial topic of discussion. Discuss the ...
Current Membership of the Patient-Centered Outcomes Research Institute (PCORI) Governing Board. Following are brief biographies of the current members of the PCORI Board of Governors.. Debra Barksdale, PhD, RN, is Professor and Associate Dean of Academic Programs at the Virginia Commonwealth University in Richmond, VA. She is a researcher, certified nurse practitioner, and educator. Her research program focuses on psychological and physical stress, coping, and cardiovascular responses in African-Americans. She is a Fellow of the American Academy of Nurse Practitioners and the American Academy of Nursing. She received a BS in nursing from the University of Virginia, a masters in nursing from Howard University, a post-masters in teaching from the University of Pennsylvania, and a PhD in Nursing Research from the University of Michigan. Dr. Barksdale was appointed in September 2010 for a 2-year term and reappointed in September 2012 for a 6-year term.. Kerry Barnett, JD, (Vice Chair) is President ...
These are not new concepts to anesthesiologists. However, much like the practice of medicine as a whole, many of our clinical decisions are not rooted in large comparative effectiveness trials. Efficacy trials are typically small, early-stage randomized controlled trials of a treatment. They often enroll a specific, high-risk patient population to maximize statistical power and require detailed protocols mandating specific care patterns and ideal use of the studied intervention. An example would be the van den Berghe et al. 6 trial of intensive insulin therapy in surgical intensive care unit patients, which demonstrated a profound mortality and morbidity benefit to targeting blood glucose levels less than 110 mg/dl. This proof-of-concept study was then rapidly extrapolated to become a mainstay of critical care protocols. A multicenter study enrolling more than 6,000 heterogeneous patients under typical care settings demonstrated lower mortality using conventional blood glucose targets.7 These ...
This query was raised by provincial health plan decision-makers earlier in 2012. Thiazide diuretics (i.e. hydrochlorothiazide) have been shown to be at least as effective as calcium channel blockers (CCBs) (e.g. amlodipine), angiotensin converting enzyme (ACE) inhibitors (e.g. lisinopril) and angiotensin receptor blockers (ARBs) (e.g. losartan). In response to this query, we will evaluate the comparative effectiveness of antihypertensive treatments among older adults without diabetes, focusing on thiazides monotherapy compared with other monotherapy.. Q2. What is the comparative effectiveness and safety of sitagliptan and NPH insulin for the management of type 2 DM not controlled by metformin plus sulfonylurea ...
Dr. Testa and colleagues are developing quantitative and health information technology methods and processes relating to the measurement and analysis of expanded patient outcomes (quality of life, cost-effectiveness and risk-benefit) for clinical, pharmacoeconomic, pharmacoepidemiologic, quality of care and comparative effectiveness research studies with particular application to primary care, cardiovascular disease, HIV, and diabetes.. Quality of Life, Patient Satisfaction, Clinical Decision Making and Comparative Effectiveness Research Dr. Testa is working on analytical, statistical and health information methods for conducting health outcomes and comparative effectivness research for pharmaceutical drug development, disease management, quality of care programs and primary care and physician subspecialty practice management. As part of this methodologic work, she is analyzing a comprehensive database of patients who have participated in large-scale clinical trials of antihypertensive and ...
The Distributed Ambulatory Research in Therapeutics Network (DARTNet) is a federated network of electronic health data from 8 organizations representing more than 500 clinicians and more than 400 000 patients. DARTNet was designed to increase knowledge of the comparative effectiveness of prescriptio …
FDA. Patient-reported outcome measures: Use in medical development to support labeling claims. 2009. From http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM193282.pdf.. This guidance describes how the Food and Drug Administration (FDA) reviews and evaluates existing, modified, or newly created patient-reported outcome (PRO) instruments used to support claims in approved medical product labeling.. Basch E, et al. Recommendations for incorporating patient-reported outcomes into clinical comparative effectiveness research in adult oncology. J Clin Oncol. 2012; 30(34): 4249-55. PMID: 23071244.. ABSTRACT: Examining the patients subjective experience in prospective clinical comparative effectiveness research (CER) of oncology treatments or process interventions is essential for informing decision making. Patient-reported outcome (PRO) measures are the standard tools for directly eliciting the patient experience. There are currently no widely accepted standards ...
Purpose - Little is known about the comparative effects of common oral antidiabetic drugs ([OADs] metformin, sulfonylureas, or thiazolidinediones [THZs]) on chronic kidney disease (CKD) outcomes in patients newly diagnosed with type 2 diabetes (T2DM) and followed in community primary care practices. Electronic health records (EHRs) were used to evaluate the relationships
case-control studies [mh] OR cohort studies [mh] OR cross-over studies [mh] OR epidemiologic studies [mh:noexp] OR cross-sectional studies [mh] OR evaluation studies as topic [mh] OR meta-analysis as topic [mh] OR practice guidelines as topic [mh] OR case control [tw] OR case controlled [tw] OR case controls [tw] OR cohort [tw]OR cohorts [tw] OR follow-up [tw] OR followup [tw] OR longitudinal [tw] OR matched-pair analysis [mh] OR observational studies [tw] OR observational study [tw] OR multicenter study [pt]) AND ((comparative study [pt] OR compare [tw] OR compares [tw] OR compared [tw] OR comparing [tw] OR comparison [tw] OR comparative [tw] OR effective [tw] OR effectiveness [tw] OR versus [ti] OR vs [ti]) AND (activities of daily living [mh] OR benefit [tw] OR benefits [tw] OR budgets [mh] OR chronic disease [mh] OR clinical trials data monitoring committees [mh] OR cognitive function [tw] OR ec [sh] OR death [mh] OR diffusion of innovation [mh] OR discharge [tw] OR economics, pharmaceutical ...
The mission of the MDEpiNet Public Private Partnerships is to develop and implement innovative methods and national/international infrastructure for robust studies and surveillance to improve our understanding of medical device safety and effectiveness throughout device life-cycle. Our main objectives are to improve how medical device information is utilized throughout the life cycle of a device and to synthesize evidence on how medical devices are used throughout their life cycle. To accomplish our mission and objectives we have brought together an array of diverse stakeholders, including other government agencies, academia, health care industry organizations, and patient and consumer groups. These stakeholders bring to the table strategic resources, skills, and expertise from a variety of domains and requires participation from all . Read More... ...
Seven studies with a total number of 9618 patients (mainly composed of non-ST elevated myocardial infarction/NSTEMI) were included. This analysis showed mortality to be similarly observed between enoxaparin and fondaparinux with OR: 1.05, 95% CI: 0.67-1.63; P = 0.84. Myocardial infarction (MI) and stroke were also not significantly different throughout different follow up periods. However, minor, major and total bleeding were significantly lower with fondaparinux (OR: 0.40, 95% CI: 0.27-0.58; P = 0.00001), (OR: 0.46, 95% CI: 0.32-0.66; P = 0.0001) and (OR: 0.47, 95% CI: 0.37-0.60; P = 0.00001) respectively during the 10-day follow up period. Even during a follow up period of 30 days or a midterm follow up, major and minor bleeding still significantly favored fondaparinux in comparison to enoxaparin. ...
The idea of CER is that researchers and scientists gather evidence and compare surgeries, medical devices, drugs, tests, or health care services, and weigh the
BACKGROUND: Adverse outcomes and resource use rates are high after hip fracture surgery. Peripheral nerve blocks could improve outcomes through enhanced
This trial is comparing the efficacy of immediate treatment with fosfomycin tromethamine [Monuril; Pierre Favre]versus symptomatic relief with ibuprofen
TY - JOUR. T1 - Directions for Effectiveness Research to Improve Health Services for Late-Life Depression in the United States. AU - Hoeft, Theresa J.. AU - Hinton, W Ladson. AU - Liu, Jessica. AU - Unützer, Jürgen. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Considerable progress has been made in the treatment of late-life depression over the past 20 years, yet considerable gaps in care remain. Gaps in care are particularly pronounced for older men, certain racial and ethnic minority groups, and those with comorbid medical or mental disorders. We reviewed the peer-reviewed literature and conducted interviews with experts in late-life depression to identify promising directions for effectiveness research to address these gaps in care. We searched the PubMed, PsychInfo, and CINHAL databases between January 1, 1998, through August 31, 2013, using terms related to late-life depression and any of the following: epidemiology, services organization, economics of care, underserved groups including health ...
In just a few days a new Obamacare tax-that will double the following year-will kick in to fund comparative effectiveness research thats supposed to help the government save money by finding ways to ration healthcare.. This is crazy; a semi-secret tax so the feds have cash to pay bureaucrats to examine everyones health records and, in turn, the government can save money by cutting back on care. The official plan, as noted by a national news wire this week, is to conduct research to find out which drugs, medical procedures, tests and treatments work best. Its part of a little-known provision of the presidents socialist takeover of the nations healthcare system.. Who will conduct this valuable research? A new quasi-governmental agency (Patient-Centered Outcomes Research Institute or PCORI) created by Obamacare to provide information about the best available evidence to help patients and their health care providers make more informed decisions. PCORI claims its research is intended to ...
Part of the mission of Health Outcomes Research in Medicine is to present evidence from outcomes research to help with decisions about which treatments to pursue and the efficacy of those treatments. In many instances, these decisions may involve comparisons of relative treatment costs in addition to relative treatment efficacy.Comparative effectiveness research (CER) has
OBJECTIVES: The purpose of this study was to compare self-reported pain and improvement of patients with symptomatic, magnetic resonance imaging-confirmed, lumbar disk herniations treated with either high-velocity, low-amplitude spinal manipulative therapy (SMT) or nerve root injections (NRI). METHODS: This prospective cohort comparative effectiveness study included 102 age- and sex-matched patients treated with either NRI or SMT. Numerical rating scale (NRS) pain data were collected before treatment. One month after treatment, current NRS pain levels and overall improvement assessed using the Patient Global Impression of Change scale were recorded. The proportion of patients, improved or worse, was calculated for each treatment. Comparison of pretreatment and 1-month NRS scores used the paired t test. Numerical rating scale and NRS change scores for the 2 groups were compared using the unpaired t test. The groups were also compared for improvement using the χ(2) test. Odds ratios with ...
Due to their condition, dialysis patients have limited access to inpatient and outpatient mental health (MH) treatment. The primary goal of this project is to establish a patient-caregiver-clinician-researcher partnership to develop a patient-centered comparative effectiveness research study that will identify potentially effective mechanisms for increasing access to and utilization of MH treatment for dialysis patients.
Drugs commonly used to treat high blood pressure, and prevent heart attacks and strokes, are associated with significantly worse cardiovascular outcomes in hypertensive African Americans compared to whites, according to a new comparative effectiveness research study led by researchers in the Department of Population Health at NYU Langone Medical Center and published in the Journal of the American College of Cardiology.
Our collective experience suggests that successful implementation of a patient- and stakeholder- engaged research paradigm involves: (1) defining the roles and process for the incorporation of input; (2) identifying the particular patients and stakeholders to build a foundation of key stakeholders who appropriately represent the target treatment population and its caregivers; (3) engaging patients and stakeholders so they appreciate the value of their own participation and have personal investment in the research process; and (4) overcoming barriers and challenges that arise and threaten the productivity of the collaboration. Engaging patients may include educating them so they understand the research process and how it is connected to changes in clinical practice, and are therefore equipped to make meaningful contributions (31). Foundations of trust and mutual respect are key elements to being able to successfully navigate all of the foreseeable and unforeseeable challenges that present ...
Section 6301(f)(2) of the Patient Protection and Affordable Care Act (PPACA) requires the Comptroller General to consider and disclose any conflicts of interest in appointing the Board of Governors on GAOs Web site.. Section 6301(a)(3) of PPACA defines conflict of interest as: [A]n association, including a financial or personal association, that have the potential to bias or have the appearance of biasing an individuals decision in matters related to the Institute or the conduct of activities under this section. Below are the associations of the Board of Governors that upon appointment by the Comptroller General, fit within PPACAs definition of a conflict of interest.. Notes: ...
CONTACT:. Lorie Slass (215) 801-4057. [email protected] FOR IMMEDIATE RELEASE August 30, 2017 Society to Improve Diagnosis in Medicine Approved for a $250,000 Engagement Award from the Patient-Centered Outcomes Research Institute Award Will Address Gap in Patient Representation in Development of Research Around Diagnostic Error and Establish a New Academy of Patient Partners. (August 30, 2017) The Society to Improve Diagnosis in Medicine (SIDM) has received a Eugene Washington PCORI Engagement Award from the Patient-Centered Outcomes Research Institute (PCORI). The 18-month project, Patients Improving Research in Diagnosis, will develop and evaluate an innovative curriculum to train Patient Partners to participate in the design, execution and dissemination of research to improve diagnosis. SIDM and its partners from Project Patient Care (PPC) and the MedStar Institute for Quality and Safety will also work together to develop a new Academy for Patient Partners. The 2015 National ...
Added participation by patients, clinicians and others in the health care community while developing comparative clinical effectiveness research studies will make such studies far more constructive.
Official website for the American Nurses Association, part of the ANA Enterprise, featuring nursing news, professional development and continuing education for nurses.
Dr. Gelfands research focuses on observational epidemiology in psoriasis and clinical trials in dermatologic diseases such as psoriasis, atopic dermatitis, cutaneous T cell lymphoma and acne/hidradenitis. Particular areas of interest include use of large medical records databases for epidemiologic and pharmacoepidemiologic studies in skin diseases and the design of efficient phase II trials for new indications of existing drugs and alternative medicines for the treatment of skin disease. Current, large ongoing projects include a prospective population-based cohort study of 8,000 psoriasis patients to evaluate cardiovascular risk and the development of the Dermatology Clinical Effectiveness Research Network (DCERN) to conduct comparative effectiveness studies in psoriasis and other dermatological diseases (www.dermcern.org ...
One of PCORIs goals is to improve the methods that researchers use for patient-centered outcomes research. PCORI funds methods projects like this one to better understand and advance the use of research methods that improve the strength and quality of comparative effectiveness research. This research project is in progress. PCORI will post the research findings on this page within 90 days after the results are final.
A UC Irvine infectious disease specialist has received a three-year, $10 million grant to explore the effectiveness of new methods to prevent staph infections in people who harbor MRSA bacteria when theyre discharged from the hospital.. The federal Agency for Healthcare Research & Quality awarded the grant as part of its CHOICE program, which is funded by American Recovery & Reinvestment Act of 2009. CHOICE grants will support large projects in comparative effectiveness research to aid decision making in priority areas of clinical care. Selected studies are deemed likely to result in major healthcare advances.. The UC Irvine study, led by Dr. Susan Huang-medical director of epidemiology & infection prevention at UC Irvine Medical Center and a UC Irvine Health Policy Research Institute affiliate-may provide the first post-discharge preventative treatments for the 1.8 million Americans each year who carry the methicillin-resistant Staphylococcus aureus bacteria.. MRSA is highly contagious and ...
Dr. Goodman is a Senior Vice President at The Lewin Group, a health care policy consulting firm based in Falls, Church, Virginia. Dr. Goodman has 30 years of experience in such areas as health technology assessment (HTA), evidence-based health care, comparative effectiveness research, health economics, and studies pertaining to health care innovation, regulation, and payment. He directs studies and projects for an international range of government agencies; pharmaceutical, biotechnology, and medical device companies; health care provider institutions; and professional, industry, and patient advocacy groups. His recent work has involved such areas as oncology, cardiovascular disease, diabetes, blood disorders, obesity, end-stage renal disease, HIV/AIDS, follow-on biologics, diagnostic testing, pharmacogenomics, personalized medicine, and organ donation and transplantation. Dr. Goodman is an internationally recognized health policy issues moderator and facilitator of expert panels, health industry ...
Dr. Robert (Robin) Hines is a cancer epidemiologist and cancer health services researcher. He received his Ph.D. in Epidemiology from the University of Alabama at Birmingham Ryals School of Public Health in 2009. The themes of Dr. Hines research concern improving the quality of cancer care and investigating trends and causes of disparities in cancer outcomes. Dr. Hines has conducted large scale epidemiologic studies to quantify and explain causes of disparate cancer outcomes for various segments of the population defined by race-ethnicity, socioeconomic status, geography, and age. He has also conducted observational comparative effectiveness research designed to provide evidence of treatment effectiveness when the data from randomized controlled trials was either nonexistent or equivocal. Overall, the goal of Dr. Hines research is to improve patient-centered, clinical, and population-level cancer outcomes. Dr. Hines research has been funded by the National Institutes of Health, the Florida ...
Topic: Update in the Care and Treatment of Patients Suffering Out of Hospital Cardiac Arrest. Speaker: Frederic S Resnic, MD MSc FACC FSCAI, Chairman, Department of Cardiovascular Medicine, The Landsman Cardiovascular Center; Co-Director, Comparative Effectiveness Research Institute, Sidney Alexander MD Chair in Cardiovascular Medicine, Lahey Hospital and Medical Center; Associate Professor of Medicine, Tufts University School of Medicine. Date/Time: 8am to 9am on Thursday 4 May 2017. Location: 1st Floor Conference Room, General Wing, KEMH. Notes:. A minimum of 50 minutes is required for CME participation. Non-physician professionals who wish to participate in the Physicians CME are urged to RSVP to 239-5918 as space is limited.. Through an agreement between the Royal College of Physicians and Surgeons of Canada and the American Medical Association, physicians may convert Royal College MOC credits to AMA PRA Category 1 Credits™. Information on the process to convert Royal College MOC credit to ...
Purpose. This was a Data Capacity-Building Project, to build a robust comparative effectiveness research infrastructure, agenda, and collaborative partnerships focused on eliminating health disparities. Specifically, a database was built comprised of all Medicaid enrollees and claims in the states that share in common both adverse minority health outcomes and the historical roots of racial health disparities in the South. Setting and Participants. A 100 percent sample of four years 2004-2007 of Medicaid Analytic Extract (MAX-file) data (plus Medicare-linked claims for dual-eligibles) from fourteen southern states, representing 3.8 to 5.4 million persons each year (one-third of all United States Medicaid enrollees, nearly half [48 percent] of African American and 21 percent of Latino Medicaid enrollees in the United States) was obtained from the Centers for Medicare and Medicaid Services (CMS). This region is the epicenter of the Black-White health disparities epidemic, and has also experienced a ...
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: ARRAOS: Recovery Act Limited Competition: Behavioral Economics for Nudging the Implementation of Comparative Effectiveness Research: Pilot Research (RC4) RFA-OD-10-002. NIA
Dr. Ilowite serves as chair of the Childhood Arthritis & Rheumatology Research Alliance, a clinical research network that performs investigator-initiated studies in pediatric rheumatic diseases. He is principal investigator on a number of NIH-sponsored projects, including studies of the use of interleukin-1 in juvenile idiopathic arthritis and comparative effectiveness research in pediatric rheumatic diseases. He is a recipient of the Lewis M. Fraad Award for Excellence in Resident Teaching at Montefiore and past chairman of the Sub-Board of Rheumatology of the American Board of Pediatrics. ...
Comparative Effectiveness Research (CER): defined by the Institute of Medicine (IOM) as the study of methods to prevent, diagnose, treat, and monitor a clinical condition or to improve the delivery of care. In reform, CER is considered an important evidence-generating tool quality and contain costs. Will be administered by an independent entity called PCORI. See Clinical Pathways and PCORI ...
The goal of our research program is to develop approaches to prevent and treat kidney disease and its complications. Chronic kidney disease (CKD) currently affects ~13% of the US population and is influenced by the growing epidemics of diabetes mellitus (DM) and obesity. Our program specifically focuses on new targets for CKD prevention to limit the rising tide in the US and globally; and outcome studies among patients with all stages of CKD to improve cardiovascular outcomes, mortality, and quality of life.. Comparative effectiveness studies of mineral metabolism treatment strategies in end stage kidney disease. In this mixed quantitative and qualitative program of study, we use electronic health record data from a large national dialysis provider linked to USRDS administrative claims, and focused interviews with patients and providers, to understand the optimal approaches for managing hyperphosphatemia and secondary hyperparathyroidism in patients with ESKD. Our ultimate goal is to design and ...
Neurosurgical biopsies and orthopaedic joint replacement were the first procedures to use robotic assistance. The first robotic cholecystectomy was performed nearly 20 years ago, and since then, robotic surgery has been increasingly widespread. Published data from the Nationwide Inpatient Sample show an increase from 2008 to 2009 in the proportion of prostatectomies, nephrectomies, hysterectomies, coronary artery bypasses, and gastrectomies performed robotically.23 Most prostatectomies and one-third of partial nephrectomies were performed robotically in 2009. Hysterectomy was the second most common (18 percent of total) robotic procedure performed in U.S. hospitals during the period of time examined. A more recent study estimates that 90 percent of prostatectomies and 20 percent of hysterectomies in the U.S. are conducted robotically.24 The diffusion of robotic prostatectomy occurred in the early 2000s, despite the lack of large comparative effectiveness studies (which first appeared in 2009), ...
This article describes the development of the Claudication Symptom Instrument (CSI) and its measurement properties for evaluating the symptom experience of patients diagnosed with intermittent claudication (IC). We conducted semi-structured qualitative interviews with IC patients for item development and cognitive interviews in which patient comprehension of items was tested. We evaluated measurement properties using data collected and analyzed in the context of an observational comparative effectiveness study of IC treatments. Items measuring five symptom important to patients were developed and cognitively tested: Pain, Numbness, Heaviness, Cramping, and Tingling. Item means (higher means worse) ranged from 1.1 (Tingling) to 2.3 (Pain) (range: 0 none to 4 extreme). Rasch analysis yielded support for an overall score (χ
TY - JOUR. T1 - Chronic lateral epicondylitis. T2 - Comparative effectiveness of a home exercise program including stretching alone versus stretching supplemented with eccentric or concentric strengthening. AU - Martinez-Silvestrini, Julio A.. AU - Newcomer, Karen L.. AU - Gay, Ralph. AU - Schaefer, Michael P.. AU - Kortebein, Patrick. AU - Arendt, Katherine W.. PY - 2005/10/1. Y1 - 2005/10/1. N2 - The objective of this study was to evaluate the effectiveness of eccentric strengthening. Ninety-four subjects (50 men) with chronic lateral epicondylitis were allocated randomly into three groups: stretching, concentric strengthening with stretching, and eccentric strengthening with stretching. Subjects performed an exercise program for six weeks. All three groups received instruction on icing, stretching, and avoidance of aggravating activities. The strengthening groups received instruction on isolated concentric and eccentric wrist extensor strengthening, respectively. At six weeks, significant ...
TY - JOUR. T1 - Response to letter regarding article, comparative effectiveness of carotid revascularization therapies. T2 - Evidence from a national hospital discharge database. AU - McDonald, Robert J.. AU - McDonald, Jennifer S.. AU - Cloft, Harry J.. N1 - Copyright: Copyright 2016 Elsevier B.V., All rights reserved.. PY - 2015/2/6. Y1 - 2015/2/6. UR - http://www.scopus.com/inward/record.url?scp=84922335512&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84922335512&partnerID=8YFLogxK. U2 - 10.1161/STROKEAHA.114.007861. DO - 10.1161/STROKEAHA.114.007861. M3 - Letter. C2 - 25550376. AN - SCOPUS:84922335512. VL - 46. SP - e42. JO - Stroke. JF - Stroke. SN - 0039-2499. IS - 2. ER - ...
Comparative Effectiveness of Adjustable Lordotic Expandable versus Static Lateral Lumbar Interbody Fusion Devices: One Year Clinical and Radiographic Outcomes
implementing their i2b2 (Informatics for Integrating Biology and the Bedside) systems and SHRINE (Shared Health Research Information Network) systems.. Omar Aldaoud, DCC Associate Director and Director of Information Security and Technology Integration, will serve as DCC project lead. We are pleased to be a part of this consortium of stellar research institutions and look forward to bringing the technological expertise available through RCMI CC to the table.. This effort has been made possible by the Patient Affordable Care Act, Dr. Mandl stated, This is a pivotal moment in healthcare, made possible by the Patient Affordable Care Act, allowing us to cross institutional boundaries and join together as patients, clinicians, advocates, leaders, and researchers to conceive and advance new models of clinical research.. The Patient-Centered Outcomes Research Institute (PCORI) awarded more than $90 million to support 29 clinical research data networks that will form a national Patient-Centered ...
TY - JOUR. T1 - Cost of Unnecessary Amylase and Lipase Testing at Multiple Academic Health Systems. AU - Ritter, Jacob P.. AU - Ghirimoldi, Federico M.. AU - Manuel, Laura S.M.. AU - Moffett, Eric E.. AU - Novicki, Thomas J.. AU - McClay, James C.. AU - Shireman, Paula K.. AU - Brimhall, Bradley B.. N1 - Funding Information: Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. This work was supported in part by the National Center for Advancing Translational Sciences, National Institutes of Health (grant numbers UL1 TR001120, UL1 TR002645, and U01 TR002393); and the Patient-Centered Outcomes Research Institute (grant number CDRN-1306-04631 pilot project grant funding to the Greater Plains Collaborative). Publisher Copyright: © 2019 American Society for Clinical Pathology, 2019. All rights reserved. For permissions, please e-mail: [email protected] PY - 2020/2/8. Y1 - 2020/2/8. N2 - Objectives: To ...
Arbor Research Collaborative for Health and the NephCure Foundation have been approved for a funding award by the Patient-Centered Outcomes Research Institute to develop and expand a health data network that will be part of PCORnet: the National Patient-Centered Clinical Research Network. This new network, the NephCure Kidney Network, is one of 29 research networks that were approved for a total of $93.5 million from PCORI to form this new national resource that aims to boost the efficiency of health research.. (AAKP launches nutrition tracker) Experts from Arbor Research will collaborate with researchers from the NephCure Foundation (NephCure) and the University of Michigan, specializing in adult and pediatric clinical nephrology, clinical research in nephrotic syndrome, epidemiology, patient advocacy, and data management. This team will develop the NephCure Kidney Network as a patient-powered research network. This new network will enable important clinical and patient-reported data on ...
Historical luminaries such as Hippocrates and Osler exhorted physicians to place the patients interests above their own, and to consider patient values for medical decision-making. Nevertheless, only in recent decades has the medical profession begun to shift from a paternalistic doctor knows best stance towards one explicitly endorsing patient-centered, evidence-based, [50-52] shared decision-making [53-55]. The growing strength of patient-orientated shared decision-making in the U.S. is exemplified by the focus on patient-centered medical homes, [56, 57] the emphasis on patient-oriented evidence that matters (POEMs), [58-60] and the Patient-Centered Outcomes Research Institute (PCORI) [61]. In the U.K., the importance of patient-oriented decision-making is highlighted in the Equity and Excellence NHS white paper and in the National Health Service Constitution [62, 63]. Following these directives, the NICE lipid guidelines state, Treatment and care should take into account individual needs ...
Washington, DC) -The Patient-Centered Outcomes Research Institute (PCORI®), selected AcademyHealth in partnership with the Patient Advocate Foundation, to serve as the Engagement Coordinating Center (ECC) for PCORnet®, the National Patient-Centered Clinical Research Network, with the goal of increasing the capacity of patients, caregivers and community members to participate in and inform the nations clinical research.. The meaningful engagement of patients, caregivers, and community members in research undertaken through PCORnet is vital to ensuring these initiatives are focused on improving outcomes most important to patients. ECC activities will focus on facilitating collaborations and information sharing across the clinical research networks of PCORnet, and amplify promising engagement practices within PCORnet® Network Partners. The lead organizations, AcademyHealth and the Patient Advocate Foundation, were selected by PCORnet Network Partners based on their expertise in engagement, ...
Marc M. Boutin, JD, is the chief executive officer of the National Health Council. He has been a leading voice for greater patient involvement at every stage of the healthcare continuum. Currently he serves as a member of the Patient-Centered Outcomes Research Institute Patient Engagement Advisory Panel, FasterCures Benefit-Risk Advisory Council, and MDIC Patient-Centered Benefit-Risk Steering Committee. He is a founding member of the international Patient-Focused Medicine Development consortium and has served on the Governing Board of the International Alliance of Patients Organizations as a member and treasurer ...
Quite often those decisions are surgical and often irreversible. Former patients and health care advocates have long complained that parents are provided inadequate information to make decisions for their child with a disorder of sex development.. But with a new award from the Patient-Centered Outcomes Research Institute (PCORI), researchers at the University of Michigan hope to provide parents with the tools needed to make decisions about disorders of sex development (DSD).. When a child with a disorder of sex development is born, parents are often experiencing enormous distress, says David E. Sandberg, Ph.D., director of the Division of Child Behavioral Health at C.S. Mott Childrens Hospital and professor of pediatrics and communicable diseases at the University of Michigan Medical School.. The right decisions about gender assignment - is it a boy or a girl - and the best course of action (for example should there be surgery? what kind? when?) are not obvious.. Parents can make decisions ...
Marshall L. Summar, MD, Division Chief, Genetics and Metabolism at Children’s National Health System, has been appointed chair of the Patient-Centered Outcome Research Institute’s (PCORI) new Advisory Panel on Rare Disease by PCORI’s Board of Governors.
Earlier this month the Center for Public Integrity (CPI) published a sharp-edged piece on PCORI-the Patient-Centered Outcomes Research Institute. The piece raised some salient issues and its timely to take stock of PCORI at the half way point of its authorized funding. (Unless renewed, PCORI sunsets in 2019.) The Affordable Care Act created PCORI as an independent nonprofit (non-government) entity. But PCORIs funding and structure makes it more or less quasi-government. It gets its money from the Medicare trust fund, treasury general funds, and a tax on private insurers and self-funded insurance plans ($2.08 per covered life). PCORI launched in late 2010 and began funding research in earnest until 2013. The main focus of that research, mandated by Congress, is to compare treatments in a way that results in meaningful results for doctors and patients as they make clinical decisions. No small task. The CPI piece probes the emerging debate about how PCORI is being operated and spending its ...
The risk of acute thrombotic events such as venous thromboembolism (VTE) and ischemic stroke in transgender women receiving hormone therapy was addressed in our longitudinal Study of Transition, Outcomes & Gender (STRONG), supported by the Patient-Centered Outcomes Research Institute. STRONG is a cohort of transgender people enrolled in Kaiser Permanentes Georgia, Northern California, and Southern California regions. This project found increased risk of VTE and ischemic stroke among transwomen treated with estrogen; however, the development of practical recommendations for the management of transwomen will require a more formal pharmacoepidemiologic analysis evaluating comparative risks of different hormone formulations, routes of administration, and doses. These data are available, but the definitive analyses were not possible due to sparse treatment-specific strata. To address these limitations, with this supplement we will include additional subjects identified at existing STRONG sites ...
Marshall L. Summar, MD, Division Chief, Genetics and Metabolism, at Children’s National has been appointed to the Patient-Centered Outcome Research Institute (PCORI)’s inaugural Advisory Panel on Rare Disease.
Purpose: : To report the two-year incidence of IOP elevations and glaucomatous optic nerve damage in patients with uveitis randomized to either FA implants or systemic therapy. Methods: : The MUST Trial is a randomized (allocation ratio 1:1), partially masked, parallel treatment comparative effectiveness trial in which patients were randomized to either FA implants or systemic therapy. Patients 13 years of age or older who had non-infectious intermediate, posterior or panuveitis in one or both eyes active within the prior 60 days for which systemic corticosteroids were indicated were eligible. Visual fields were obtained at baseline and every twelve months using the Humphrey 24-2 SITA-fast protocol and were repeated if they were unreliable or abnormal at baseline. Optic nerve photos were taken in stereo at a nominal 30 or 35 degree angle depending on the fundus camera used at baseline and at three, six, and twelve month follow-up visits and annually thereafter. Glaucoma was diagnosed on the ...
TY - JOUR. T1 - Hypertension Self-management in Socially Disadvantaged African Americans. T2 - the Achieving Blood Pressure Control Together (ACT) Randomized Comparative Effectiveness Trial. AU - Boulware, L. Ebony. AU - Ephraim, Patti L.. AU - Hill-Briggs, Felicia. AU - Roter, Debra L.. AU - Bone, Lee R.. AU - Wolff, Jennifer L.. AU - Lewis-Boyer, La Pricia. AU - Levine, David M.. AU - Greer, Raquel C.. AU - Crews, Deidra C.. AU - Gudzune, Kimberly A.. AU - Albert, Michael C.. AU - Ramamurthi, Hema C.. AU - Ameling, Jessica M.. AU - Davenport, Clemontina A.. AU - Lee, Hui Jie. AU - Pendergast, Jane F.. AU - Wang, Nae Yuh. AU - Carson, Kathryn A.. AU - Sneed, Valerie. AU - Gayles, Debra J.. AU - Flynn, Sarah J.. AU - Monroe, Dwyan. AU - Hickman, Debra. AU - Purnell, Leon. AU - Simmons, Michelle. AU - Fisher, Annette. AU - DePasquale, Nicole. AU - Charleston, Jeanne. AU - Aboutamar, Hanan J.. AU - Cabacungan, Ashley N.. AU - Cooper, Lisa A.. N1 - Publisher Copyright: © 2019, Society of General ...
Dr. Yu is the director of genitourinary cancers radiotherapy and co-director of the gamma knife program for the department of Therapeutic Radiology at the Yale School of Medicine. As a former Yale Center for Clinical Investigation scholar and member of the Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center at Yale, Dr. Yus research centers on the comparative effectiveness of new radiation technologies and how these new technologies are adopted nationally. Dr. Yu is currently a Senior Editor of the journal Practical Radiation Oncology, and is on the editorial boards of the Journal of Clinical Oncology, Journal of Clinical Oncology - Clinical Cancer Informatics, Journal of Surgical Oncology, and Oncology (Williston Park). ...
This report summarizes the available evidence on the comparative efficacy, effectiveness, and harms of 12 second-generation antidepressants: bupropion, citalopram, duloxetine, escitalopram, fluoxetine, fluvoxamine, mirtazapine, nefazodone, paroxetine, sertraline, trazodone, and venlafaxine in treating patients with MDD, dysthymia, and subsyndromal depression. It also evaluates the comparative efficacy and effectiveness for maintaining remission and for treating accompanying symptoms such as anxiety, insomnia, or neurovegetative symptoms.
The International Society for Pharmacoeconomics and Outcomes Research (ISPOR) and the International Society for Pharmacoepidemiology (ISPE) created a task force to make recommendations regarding good procedural practices that would enhance decision makers confidence in evidence derived from RWD studies. Peer review by ISPOR/ISPE members and task force participants provided a consensus-building iterative process for the topics and framing of recommendations ...
I am a clinical cardiac electrophysiologist, and I study the comparative effectiveness, cost-effectiveness and clinical outcomes associated with cardiac arrhythmias and their treatments. , cardiac electrophysiology and exercise physiology. I have an NIH funded career development award (K23) to study the comparative effectiveness of ablation for atrial fibrillation compared with medical therapy for the prevention of long term adverse outcomes such as death and ischemic stroke. I am also conducting research sponsored by the American Heart Association and industry focused on ICD therapy, heart failure, and atrial fibrillation.. Specialized Terms: Arrhythmias; atrial fibrillation; atrial flutter; ventricular tachycardia; ventricular fibrillation; implantable cardioverter-defibrillator; cardiac ablation; outcomes research; cost- ...
Rheumatoid arthritis (RA) is a chronic debilitating disease characterized by progressive joint damage, reduced quality of life, loss of productivity and premature death. It affects 1% of the adult US population, and is one of the most demanding diseases on our healthcare resources. Biologic disease modifiers are new drugs that provide hope to improve the course of RA; however, biologics are among the most expensive specialty drugs. Although the treatment costs of RA have recently increased with the introduction of biologics, most of the economic and societal impacts are due to consequences of RA rather than direct treatment costs. Thus, the cost-effectiveness of biologics in RA is of high priority as recognized by many agencies including the National Institute of Health. This thesis focuses on three limitations of the current cost-effectiveness analyses (CEA) of biologics in RA. First, Most CEAs are based on randomized clinical trials (RCT) that are rarely applicable to real-life clinical ...
Comparative Study; Journal Article; Meta-Analysis; Research Support, Non-U.S. Govt; Review; Blood Transfusion, Autologous; Botulinum Toxins; Glucocorticoids; Humans; Hyaluronic Acid; Platelet-Rich Plasma; Polyethylene Glycols; Randomized Controlled Trials as Topic; Sclerosing Solutions; Tennis Elbow; Viscosupplements ...
Background: High rates of adverse birth outcomes persist in the United States despite increased access to individual prenatal care (IPNC). Psychosocial factors influence birth outcomes and affect infant and child development and maternal functioning. Group prenatal care (GPNC) combines individual physical assessments and facilitated group education and support. Studies of GPNC show promising results, including lowered preterm birth rates, but the GPNC psychosocial mechanisms influencing birth outcomes are unclear. Methods: Surveys at study enrollment (N=248), late pregnancy, and six weeks postpartum assessed psychosocial effects of each PNC model. Multiple regression models and planned moderator analyses tested whether GPNC participants had better outcomes compared to IPNC, as main effects and for at-risk subgroups. Frequent, brief semi-structured interviews with 29 women during pregnancy through six weeks postpartum were conducted and analyzed to describe important PNC functions and how experiences and
OBJECTIVE To compare three continuous glucose monitoring (CGM) devices in subjects with type 1 diabetes under closed-loop blood glucose (BG) control. RESEARCH DESIGN AND METHODS Six subjects with type 1 diabetes (age 52 ± 14 years, diabetes duration 32 ± 14 years) each participated in two 51-h closed-loop BG control experiments in the hospital. Venous plasma glucose (PG) measurements (GlucoScout, International Biomedical) obtained every 15 min (2,360 values) were paired in time with corresponding CGM glucose (CGMG) measurements obtained from three CGM devices, the Navigator (Abbott Diabetes Care), the Seven Plus (DexCom), and the Guardian (Medtronic), worn simultaneously by each subject. Errors in paired PG-CGMG measurements and data reporting percentages were obtained for each CGM device. RESULTS The Navigator had the best overall accuracy, with an aggregate mean absolute relative difference (MARD) of all paired points of 11.8 ± 11.1% and an average MARD across all 12 experiments of 11.8 ± ...
Ninety-six samples from hepatitis B virus (HBV)-infected individuals were used to compare ViveST samples to frozen samples in COBAS TaqMan, RealArt, and VERSANT. Correlation (r) between ViveST samples and frozen samples was 0.99 in all three platforms. Correlations among tests using frozen samples were 0.96 for COBAS and RealArt, 0.94 for COBAS and VERSANT, and 0.97 for VERSANT and RealArt. The results indicate that ViveST may be useful in clinical practice. Different HBV-VL platforms correlated well with one another. ...
Our analyses show the renoprotective effects and superiority of using ACE inhibitors in patients with diabetes, and available evidence is not able to show a better effect for ARBs compared with ACE inhibitors. Considering the cost of drugs, our findings support the use of ACE inhibitors as the first …
The proportion of the elderly people (e65 years) has continued to increase among over half a million Americans with end-stage renal disease (ESRD). In 1990, 200...
The Gelfand Clinical Research Lab designs and conducts clinic-based and population-based observational studies and interventional and translational clinical trials in common and rare skin diseases. Gelfand and his team focus on pharmacoepidemiology, patient centered outcomes and effectiveness research, psychometrics and instrument/diagnostic test development, and human translational studies aimed at development of novel treatment approaches and further understanding disease pathogenesis. A major goal of the Gelfands research program is improving psoriasis patient outcomes in the skin and joints, while lowering the risk of diabetes, cardiovascular disease and mortality.
Cancer Outcomes, Public Policy, and Effectiveness Research Center, Yale Cancer Center and Yale University School of Medicine, New Haven, CT, USA; Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA ...
There were some reported deaths in people taking Bactrium, who were also hypertensives on ACE-I. So the Canadian Researches looked into this issue. This resulted in a paper published in the BMJ 30th Oct issue. The paper is entitled, Co-trimoxazole and sudden cardiac deaths in patients taking inhibitors of Renin Angiotensin system.. The study was led by Dr Michael Fralich From the Canadian Drug Safety and Effectiveness Research Center. They review the hospitalisation data and discharged data of the Ontario Health District from 1st April 1994 till 1st Jan 2012. There were all together 39,879 sudden cardiac deaths. They analysed those who had received ACEI / ARB and also antibiotics Co-trimoxazole and also ciprofloxacin and two other antibiotics. These SCD were matched against 3,733 patients of the same age and sex group and who also have the same co-morbid factors of T2DM and kidney disease. These were used as matched controls ...
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This article is from a peer-reviewed journal article on Sawtooth Softwares ACBC (Adaptive CBC) approach. Indeed, most ACBC research has been published at the Sawtooth Software and joint SKIM/Sawtooth Software conferences, which arent subject to a formal academic review process. Were pleased to point you to an article recently published in a peer-reviewed healthcare economics journal entitled The Patient: Patient-Centered Outcomes Research.. The article is authored by Charles E. Cunningham, Ken Deal, and Yvonne Chen.. The authors review previous ACBC studies involving consumer electronics, home purchases, PCs, automobiles, fast food, mobile telephone, chemical products, and consumer durables. They conclude:. A review of randomized trials and cross-over studies suggests that, although ACBC surveys require more time than conventional approaches to CA, informants find ACBC surveys more engaging. In most studies, ACBC surveys yield lower standard errors, improved prediction of hold-out task ...
TY - JOUR. T1 - Application of a Risk Score to Identify Older Adults with Community-Onset Pneumonia Most Likely to Benefit From Empiric Pseudomonas Therapy. AU - Frei, Christopher R.. AU - Rehani, Sylvie. AU - Lee, Grace C.. AU - Boyd, Natalie K.. AU - Attia, Erene. AU - Pechal, Ashley. AU - Britt, Rachel S.. AU - Mortensen, Eric M.. N1 - Funding Information: Dr. Mortensen was supported in part by the University of Texas Southwestern Center for Patient-Centered Outcomes Research. This material is the result of work supported with resources and the use of facilities at the South Texas Veterans Health Care System. The views expressed in this article are those of the authors and do not necessarily represent the views of the Department of Veterans Affairs or the National Institutes of Health.. PY - 2017/2/1. Y1 - 2017/2/1. N2 - Study Objective: To assess the impact of empiric Pseudomonas pharmacotherapy on 30-day mortality in hospitalized patients with community-onset pneumonia stratified according ...
My research is focused on development and application of novel statistical methods in genetic epidemiology, anesthesiology, patient-centered outcomes research
This paper presents a protocol for a randomised controlled trial of the Cardiac-Diabetes Transcare program which is a transitional care, multi-modal self-management program for patients with acute coronary syndrome comorbid with type 2 diabetes. Prior research has indicated people hospitalised with dual cardiac and diabetes diagnoses are at an elevated risk of hospital readmissions, morbidity and mortality. The primary aim of this study is to evaluate the effectiveness (and cost-effectiveness) of a Cardiac-Diabetes Transcare intervention program on 6-month readmission rate in comparison to usual care. A two-armed, randomised controlled trial with blinded outcome assessment will be conducted to evaluate the comparative effectiveness of two modes of care, including a Usual Care Group and a Cardiac-Diabetes Transcare Intervention (in addition to usual care) Group. The primary outcome is 6-month readmission rate, although a range of secondary outcomes will be collected (including self-efficacy) at baseline,