387501517 - EP 0983983 A3 2000-07-05 - Combinatorial synthesis and analysis of organometallic compounds and catalysts - [origin: EP0978499A2] Methodologies for the synthesis, screening and characterisation of organometallic compounds and catalysts (eg homogenous catalysts), including combinatorial synthesis, screening and characterisation of libraries of supported and unsupported organometallic compounds and catalysts (eg homogenous catalysts). The methods can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (eg homogeneous catalysts), but also as additives and therapeutic agents.[origin: EP0978499A2] Methodologies for the synthesis, screening and characterisation of organometallic compounds and catalysts (eg homogenous catalysts), including combinatorial synthesis, screening and characterisation of libraries of supported and unsupported organometallic compounds and catalysts (eg homogenous catalysts). The methods can be
Dynamic combinatorial chemistry utilises reversible reactions to set up a dynamic library of molecules, with the library composition determined by the thermodynamic stability of each library member. Upon addition of a protein template, any library members which bind to the template are stabilised and amplified. Analysis of the library composition enables the identification of molecules which bind to the template protein. The suitability of two enzyme catalysed reactions catalysed by N-acetylneuraminic acid aldolase and subtilisin® Carlsberg was investigated for use in the synthesis of a DCL. A 173 component dynamic combinatorial library was successfully synthesised using these reactions with the resulting library screened against two protein template molecules, wheat germ agglutinin and Div1B. Several methods were investigated for the simplification of DCL analysis including the immobilisation of protein template molecules and the segregation of DCL proteins using semi-permiable membranes, ...
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Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research.
TY - JOUR. T1 - A Planning Strategy for Diversity-Oriented Synthesis. AU - Burke, Martin D.. AU - Schreiber, Stuart L.. PY - 2004/12/22. Y1 - 2004/12/22. N2 - In contrast to target-oriented synthesis (TOS) and medicinal or combinatorial chemistry, which aim to access precise or dense regions of chemistry space, diversity-oriented synthesis (DOS) populates chemical space broadly with small-molecules having diverse structures. The goals of DOS include the development of pathways leading to the efficient (three- to five-step) synthesis of collections of small molecules having skeletal and stereochemical diversity with defined coordinates in chemical space. Ideally, these pathways also yield compounds having the potential to attach appendages site- and stereoselectively to a variety of attachment sites during a post-screening, maturation stage. The diverse skeletons and stereochemistries ensure that the appendages can be positioned in multiple orientations about the surface of the molecules. TOS as ...
Since oxidative cellular damage contributes to the development of cancers, heart disease and ageing, the synthesis of antioxidative agents which are able to either prevent or mitigate oxidative stress to cells is an important area of investigation. Combinatorial chemistry has had a profound impact on the discovery and optimisation of potential lead compounds, especially in the medicinal field. This review details recent examples of combinatorial chemistry dealing with the synthesis of novel antioxidants with an emphasis on solid phase compound synthesis and parallel library synthesis.. Full text not available from this repository.. ...
Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews dealing with various topic...
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The goal of this thesis was to develop a method for efficiently synthesizing a large suite of asymmetric oligoester ion channel-forming compounds. A solid-phase organic synthesis (SPOS) approach on Wang resin was used to generate the ion channel candidates. A follow-on goal is to survey the compounds produced to uncover structure-related controls on ion transport activity. Two classes of building blocks were used to generate the oligoesters - head groups and cores. The core building blocks were three omega-hydroxy acid derivatives six, eight and twelve carbons in length and the alcohol protected as a tetrahydropyranyl ether. The head group building blocks were either a glutaric acid monoester derivative of varying lipophilicity (12 to 16 carbon long alkyl tail) or a beta-hydroxy acid derivative; these building blocks used a tert-butyldimethylsilyl ether for alcohol protection. Optimized conditions for building block coupling, deprotection, and product cleavage were first established by the ...
Combinatorial methods represent an appealing experimental method for the discovery of heterogeneous catalysts. One can efficiently identify candidate materials or sample vast regions of composition space using a combination f dense catalyst libraries and high-throughput reactivity screening techniques. This is particularly appealing for the discovery of novel catalysts for low temperature fuel cells where multi-component systems have shown improved performance.
Establishing synthesis methods for a target material constitutes a grand challenge in materials research, which is compounded with use-inspired specifications on the format of the material. Solar photochemistry using thin film materials is a promising technology for which many complex materials are being proposed, and the present work describes application of combinatorial methods to explore the synthesis of predicted La-Bi-Cu oxysulfide photocathodes, in particular alloys of LaCuOS and BiCuOS. The variation in concentration of three cations and two anions in thin film materials, and crystallization thereof, is achieved by a combination of reactive sputtering and thermal processes including reactive annealing and rapid thermal processing. Composition and structural characterization establish composition-processing-structure relationships that highlight the breadth of processing conditions required for synthesis of LaCuOS and BiCuOS. The relative irreducibility of La oxides and limited diffusion ...
TentaGel® Macrobeads are highlighted by extraordinary large particle diameters and high capacities based on the TentaGel® technology and designed for single bead synthesis and single bead analysis ...
Multicomponent reactions are flexible reactions for the rapid generation of complex molecules with often biologically relevant scaffold structures. Combined with the ease of parallelization and the exploratory power with regard to chemical space, multicomponent reactions have attracted significant attention
Enzyme inhibition forms the basis of much of the medicinal chemistry used in the treatment of disease. β-Sultams are cyclic sulfonamides which are both β-lactam analogues and potential pro drugs of taurine and substituted taurines: as their hydrolysis products. Two β-sultams, their hydrolysis products and a range of dicarboxylic acids were tested as inhibitors of BcII, a metallo-β-lactamase enzyme. The two β-sultams, their hydrolysis products and some related compounds were also tested as inhibitors of glutamine synthetase following work showing that β-sultam has an effect on neurotransmission in the CNS.. A novel β-sultam, 1,2-thiazetidine-3-carboxylate 1,1-dioxide (3-carboxy-β-sultam), has been synthesised via a four-step process from L cystine including the removal of a benzyl ester group from benzyl 3-carboxylate-β-sultam utilising sodium in liquid ammonia. The product has been characterised by NMR and MS.. The rate of hydrolysis of 3-carboxy-β-sultam was investigated using 1H NMR ...
Title:Tandem Multicomponent Reactions Toward the Design and Synthesis of Novel Antibacterial and Cytotoxic Motifs. VOLUME: 20 ISSUE: 11. Author(s):Mohammad H. Semreen, Raafat El-Awady, Raed Abu-Odeh, Maha Saber-Ayad, Raed A. Al-Qawasmeh, Salem Chouaib, Wolfgang Voelter and Taleb H. Al-Tel. Affiliation:Sharjah Institute for Medical Research, University of Sharjah, P.O.Box 27272, Sharjah, UAE.. Keywords:Imidazopyridines, Ugi reaction, multicomponent reaction, Groebke-Blackburn reaction, antibacterial, hospital resistant strains, anticancer.. Abstract:The synthesis of polysubstituted imidazopyridines and imidazopyrazines through the orthogonal union of Groebke-Blackburn and Ugi reactions is described. These motifs were produced efficiently in a tandem operation without intermediate isolation. The synthesized scaffolds were biologically evaluated and found to posses potent anticancer and antibacterial activities. Importantly, some of these motifs (e.g. compound 5) were found to possess specific ...
International Scholarly Research Notices is a peer-reviewed, Open Access journal covering a wide range of subjects in science, technology, and medicine. The journals Editorial Board as well as its Table of Contents are divided into 108 subject areas that are covered within the journals scope.
The designing, synthesizing and screening of one-bead-one-compound (OBOC) combinatorial chemistry libraries against a single target ligand has been well developed. Recently, novel cholesterol/peptide hybrid combinatorial One-Bead-One-Compound (OBOC) combinatorial libraries have been developed and synthesized with self folding capabilities. The library design strategy was based on a similar pentamer and hexamer self-folding branched tricylic libraries previously developed. The cholic acid on the side chain of the carboxyl lysine is believed to interact with fixed hydrophobic amino acids at the amino-termini (position 5) of the twin branched L-amino acid arms and self-fold into a tricyclic molecule. The newly synthesized library has arginine (R) and Lysine (K) down-proportioned to 10 % for each position to decrease the probability of positive charge nonspecific binding. Thirty L-, D-, and unnatural amino acids were used in each position as building blocks. Hydrophobicity was fixed at position 5 ...
An apparatus for high-throughput combinatorial syntheses of organic molecules including a reaction vessel for containing a combinatorial-chemistry synthetic reaction, a liquid dispenser for dispensing the liquid, a liquid aspirator and an adjustment mechanism. The reaction vessel includes an ingress aperture allowing a liquid to enter into an interior of the vessel and an egress aperture for aspirating the liquid from the vessel. The liquid dispenser dispenses liquid through the ingress aperture. The liquid aspirator aspirates liquid through the egress aperture and includes a rotor for carrying the vessel and orbiting the vessel about an axis of rotation. The rotor is oriented generally in a horizontal plane and includes an adjustment mechanism for adjusting the angle of the vessel relative to the horizontal plane in response to the centrifugal force generated by orbiting the vessel about the axis of rotation. A method of combinatorial synthesis of organic molecules is also disclosed.
Systems and methods for providing in situ, controllably variable concentrations of one, two or more chemical components on a substrate to produce an integrated materials chip. The component concentrations can vary linearly, quadratically or according to any other reasonable power law with one or two location coordinates. In one embodiment, a source and a mask with fixed or varying aperture widths and fixed or varying aperture spacings are used to produce the desired concentration envelope. In another embodiment, a mask with one or more movable apertures or openings provides a chemical component flux that varies with location on the substrate, in one or two dimensions. In another embodiment, flow of the chemical components through nuzzle slits provides the desired concentrations. An ion beam source, a sputtering source, a laser ablation source, a molecular beam source, a chemical vapor deposition source and/or an evaporative source can provide the chemical component(s) to be deposited on the substrate.
Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease.: A phenotypic high-throughput screen using ∼100,000 compounds prepared usin
N-Acylsulfonamides usually react with nucleophiles by acyl transfer and C-N bond fission. However, the hydrolysis of N-acyl -sultams is a sulfonyl transfer reaction that occurs with S-N fission and opening of the four-membered ring. Similar to other -sultams, the N-acyl derivatives are at least 106-fold more reactive than N-acyl sulfonamides. 3-Oxo--sultams are both -lactams and -sultams but also hydrolyze with preferential S-N bond fission.. ...
TentaGel® resins are grafted copolymers consisting of a low crosslinked polystyrene matrix on which polyethylene glycol (PEG or POE) is grafted. The PEG spacer is attached to the matrix via an ethyl ether group which increases stability towards acid treatment and minimizes PEG-leaching. As PEG is a chameleon type polymer with hydrophobic and hydrophilic properties, the graft copolymer shows modified physico chemical properties which are highly dominated by the PEG moiety (and no longer by the polystyrene matrix). These graft copolymers are pressure stable and can be used in batch processes as well as under continuous flow conditions. The PEG spacer is in the range of MW 3000 Da. This resin is synthesized from TentaGel® amine and the base labile 4-(hydroxymethyl)benzoic acid linker. It is a versatile support for the immobilization of carboxylic acids. The resulting ester bond is stable to strong acids but is cleaved by nucleophiles like amines, hydrazine or alkoxides. ...
Isogenica, Cambridge UK and Imperial College London secure funding from UKs Technology Strategy Board to develop gene library synthesis for synthetic
A novel bacteriophage lambda vector system was used to express in Escherichia coli a combinatorial library of Fab fragments of the mouse antibody repertoire. The system allows rapid and easy identification of monoclonal Fab fragments in a form suitable for genetic manipulation. It was possible to generate, in 2 weeks, large numbers of monoclonal Fab fragments against a transition state analog hapten. The methods described may supersede present-day hybridoma technology and facilitate the production of catalytic and other antibodies.. ...
FIG: 3 ORGANIC SYNTHESIS USING SOLID SUPPORT. 1) A cross linked, insoluble polymeric material that is inert to the condition of synthesis;. 2) Some means of linking the substrate to this solid phase that permits selective cleavage of some or all of the product from the solid support during synthesis for analysis of the extent of reaction(s), and ultimately to give the final product of interest;. 3) A chemical protection strategy to allow selective protection and deprotection of reactive groups.. Merrifield developed a series of chemical reactions that can be used to synthesise proteins. The direction of synthesis is opposite to that used in the cell. The intended carboxy terminal amino acid is anchored to a solid support. Then, the next amino acid is coupled to the first one. In order to prevent further chain growth at this point, the amino acid, which is added, has its amino group blocked. After the coupling step, the block is removed from the primary amino group and the coupling reaction is ...
AIM AND OBJECTIVE: The importance of acridine core structure and other heterocycles containing its framework is well known, as they are found in numerous compounds with a variety of biological effects. Pyridine is also an important solvent and heterocyclic nucleus for the design and synthesis of novel molecules with biological properties. It occurs in several natural compounds which are used as a precursor in agrochemicals and pharmaceuticals. The utility of nanostructured metal salts because of their small size and high surface area as catalysts in organic synthesis has drawn special attention due to their better properties such as slower reaction rate, reusability of the catalyst, and higher yields of products compared to the bulk size ...
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PharmaSeq, Inc., is a private company located near Princeton, NJ. Its business is in developing an ultra-small microtransponder tagging platform that has broad applications for the tagging and tracking of objects used in the consumer goods, industrial goods, life sciences and eventually clinical diagnostics industries.
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A versatile copper(i)-catalyzed cascade multicomponent reaction strategy between readily available (Z)-3-iodoacrylic acids, terminal alkynes, and primary amines is reported, leading to a great diversity of complex heterocyclic backbones based on biorelevant indole/lactam scaffolds.
The use of cyclic peptides in one-bead-one-compound libraries is limited by difficulties in sequencing hit compounds. Lacking a free N-terminal amine, such peptides cannot be sequenced by the Edman degradation approach, and complex fragmentation patterns are obtained by tandem mass spectrometry. To overcome this problem, we designed an alternative approach introducing a methionine residue within the macrocycle and as a linker to allow simultaneous ring-opening and release from the resin upon treatment with cyanogen bromide. The methionine linker was inverted relative to the peptide chain to allow the synthesis of cyclic peptides anchored by a lysine side chain and to avoid the presence of two C-terminal homoserine lactones on the released linear peptides. After MALDI-TOF MS/MS analysis, the peptides released from a single bead were sequenced manually and with a de novo sequencing software. The strategy described herein is compatible with commonly used amino acids and allows sequencing of cyclic ...
Dynamic covalent chemistry (DCvC) is a synthetic strategy employed by chemists to make complex supramolecular assemblies from discrete molecular building blocks. DCvC has allowed access to complex assemblies such as covalent organic frameworks, molecular knots, polymers, and novel macrocycles. Not to be confused with dynamic combinatorial chemistry, DCvC concerns only covalent bonding interactions. As such, it only encompasses a subset of supramolecular chemistries. The underlying idea is that rapid equilibration allows the coexistence of a variety of different species among which molecules can be selected with desired chemical, pharmaceutical and biological properties. For instance, the addition of a proper template will shift the equilibrium toward the component that forms the complex of higher stability (thermodynamic template effect). After the new equilibrium is established, the reaction conditions are modified to stop equilibration. The optimal binder for the template is then extracted ...
The Chemical Biology Thematic Group is engaged in a diverse range of research topics which span structural biology, enzymology, nucleic acid research, signalling pathways, single molecule biophysics, and biophysical chemistry of living tissues. Among the themes which unite the research being performed in this group is trying to learn new chemistry and physics from biological systems. We have projects relating to pharmaceutically relevant enzymes such as those involved in drug metabolism and antibiotic resistance; development of therapeutic agents in the control of inflammation, cancer and viral infections; the chemical biology of NO; quantification of bioenergetic markers of metabolism; self-assembly mechanisms of the HIV-1 virion capsid; liposome microarray systems to address membrane protein dynamics and recognition; studies on reactive oxygen species translocation across the aqueous/lipid membrane interface; RNAi/antisense technologies; dynamic combinatorial chemistry; protein dynamics and ...
Related Articles. Structure-Based Design of Inhibitors of the Aspartic Protease Endothiapepsin by Exploiting Dynamic Combinatorial Chemistry.. Angew Chem Int Ed Engl. 2014 Feb 14 ...
The blood-brain barrier (BBB) is a biological barrier that protects the brain from neurotoxic agents and regulates the influx and efflux of molecules required for its correct function. This stringent regulation hampers the passage of brain parenchyma-targeting drugs across the BBB. BBB shuttles have been proposed as a way to overcome this hurdle because these peptides can not only cross the BBB but also carry molecules which would otherwise be unable to cross the barrier unaided. Here we developed a new high-throughput screening methodology to identify new peptide BBB shuttles in a broadly unexplored chemical space. By introducing d-amino acids, this approach screens only protease-resistant peptides. This methodology combines combinatorial chemistry for peptide library synthesis, in vitro models mimicking the BBB for library evaluation and state-of-the-art mass spectrometry techniques to identify those peptides able to cross the in vitro assays. BBB shuttle synthesis was performed by the ...
TY - JOUR. T1 - Inactivation of Bacterial DD-Peptidase by β-Sultams. AU - Llinás, Antonio. AU - Ahmed, Naveed. AU - Cordaro, Massimiliano. AU - Laws, Andrew P.. AU - Frère, Jean Marie. AU - Delmarcelle, Michael. AU - Silvaggi, Nicholas R.. AU - Kelly, Judith A.. AU - Page, Michael I.. PY - 2005/5/31. Y1 - 2005/5/31. N2 - N-Acyl-β-sultams are time-dependent, irreversible active site-directed inhibitors of Streptomyces R61 DD-peptidase. The rate of inactivation is first order with respect to β-sultam concentration, and the second-order rate constants show a dependence on pH similar to that for the hydrolysis of a substrate. Inactivation is due to the formation of a stable 1:1 enzyme-inhibitor complex as a result of the active site serine being sulfonylated by the β-sultam as shown by ESI-MS analysis and by X-ray crystallography. A striking feature of the sulfonyl enzyme is that the inhibitor is not bound to the oxyanion hole but interacts extensively with the roof of the active site where ...
Hepatitis C virus (HCV) poses a major health threat to the world. The recent development of direct-acting antivirals (DAAs) against HCV has markedly improved the response rate of HCV and reduced the side effects in comparison to the interferon-based therapy. Despite this therapeutic advance, there is still a need to develop new inhibitors that target different stages of the HCV life cycle because of various limitations of the current regimens. In this study, we performed a quantitative high throughput screening of the Molecular Libraries Small Molecule Repository (MLSMR) of ∼350,000 chemicals for novel HCV inhibitors using our previously developed cell-based HCV infection assay. Following confirmation and structural clustering analysis, we narrowed down to 158 compounds from the initial ∼3000 molecules that showed inhibitory activity for further structural and functional analyses. We were able to assign the majority of these compounds to specific stage(s) in the HCV life cycle. Three of them ...
This focus review documents the developments in polymer synthesis that involve multicomponent reactions (MCRs) and related sequential reaction systems. Postpolymerization modification and step-growth polymerization reactions based on MCRs and sequential reactions such as the Kabachnik-Fields three-component reaction (KF-3CR) are described. Welcoming more participants in a polymer synthesis; recent years, multicomponent reactions (MCRs) have been gradually integrated into synthetic polymer chemistry, which led to a new synthetic toolbox for a range of interdisciplinary applications. In this focus review, this new trend in polymer chemistry has been summarized with including contributions from the author.
This paper reports the synthesis and screening of a combinatorial peptide library for new affinity ligands for glycosylated haemoglobin (HbA(1c)), which is an important indicator of diabetes control. The new ligands are suitable for large-scale synthesis and overcome the disadvantages of antibodies (unstable and expensive to produce etc.), while remaining as efficient as antibodies in binding to the analyte. The library consisted of 262 144 hexapeptides synthesised using the one-bead-one-compound technique. The hexapeptides attached onto beads were screened with glycosylated haemoglobin HbA(1c). The structures of the peptides exhibiting high affinity were characterised by Edman microsequencing. Computer modelling simulation of one of the lead sequences has shown that this class of ligand has a high affinity and specificity for glycosylated haemoglobin. (C) 1998 Elsevier Science S.A. All rights reserved.. ...
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TY - JOUR. T1 - Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M1 positive allosteric modulators. AU - Yang, Feng V.. AU - Shipe, William D.. AU - Bunda, Jaime L.. AU - Nolt, M. Brad. AU - Wisnoski, David D.. AU - Zhao, Zhijian. AU - Barrow, James C.. AU - Ray, William J.. AU - Ma, Lei. AU - Wittmann, Marion. AU - Seager, Matthew A.. AU - Koeplinger, Kenneth A.. AU - Hartman, George D.. AU - Lindsley, Craig W.. PY - 2010/1/15. Y1 - 2010/1/15. N2 - An iterative analog library synthesis approach was employed in the exploration of a quinolone carboxylic acid series of selective M1 positive allosteric modulators, and strategies for improving potency and plasma free fraction were identified.. AB - An iterative analog library synthesis approach was employed in the exploration of a quinolone carboxylic acid series of selective M1 positive allosteric modulators, and strategies for improving potency and plasma free fraction were identified.. KW - M. KW - Positive allosteric ...
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Two different methods are available for synthesizing random peptide libraries. The first technique is known as Split and Mix method which consists of three basic steps: splitting, coupling and mixing. Firstly, resin beads are split in a number of aliquots that equals the number of building blocks to be utilized in the synthesis (splitting). Then, to each resin aliquot one building block is coupled and the reactions are driven to completion (coupling). Following this step, beads are randomly and thoroughly mixed (mixing) and then re-splitted in the same number of aliquots, achieving a set of homogeneous and equimolar collections of compounds. Repetitive execution of these basic steps for n times will thus produce a rapid increase of newly generated molecules, while bead number remains constant. Resin beads encounter one reactant at a time, no more than one compound per bead can be generated (one-bead one-compound-OBOC-library). As reactions are driven to completion, all peptides are generated ...
International trade is stepping into the age of digitally enabled trade, driven by cross-border data flows and interoperability. Concerns for cybersecurity, privacy, and digital sovereignty have prompted the widespread implementation of trade policies regulating cross-border data flows. At present, there is a deficit of information characterizing such policies and analyzing their role in the global economy. We address this deficit through a quantitative analysis of trade in services that seeks both to categorize data-related trade policies and to evaluate the extent to which they are similar to other restrictive measures. We propose a mixture-based clustering pipeline to group trade restrictiveness data and a method for quantifying the difference between the cross-border data flow regulations and other traditional regulations. Our analysis reveals that a significant localization effect among data flow restrictions and that, while highly restrictive data flow policies generally do not overlap with other
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Perspectives, compilations, and reviews of modern drug discovery methods:. Bunin, B. A.; Bajorath, J.; Morales, G.; Siesel, B. Cheminformatics: Theory, Practice, and Products 2006, Springer-Verlag, manuscript in press, A summary of the theory and features of the available modern cheminformatics tools.. Bunin, B. A. Increasing the Efficiency of Small Molecule Drug Discovery (In response to an interview with Chris Lipinski on current challenges) Drug Discovery Today 2003, 8, 18, 823-826.. Bunin, B. A.; Dener, J. M.; Livingston, D. A. Application of Combinatorial and Parallel Synthesis to Medicinal Chemistry Annu. Rep. Med. Chem. 1999, 34, 267-286.. Bunin, B. A. The Combinatorial Index 1998, pp. 1-322, Academic Press, An exhaustive compilation on methods for the combinatorial synthesis of small molecules widely used by synthetic chemists.. Morales, G. A.; Bunin, B. A. Guest Editors, Comb. Chem. & HTS., 2004, 7, 5. 397-529. Morales, G. A.; Bunin, B. A. Editors, Methods Enzymol., 2003, 369, ...
The selection, acquisition, and use of high‐quality small molecule libraries for screening is an essential aspect of drug discovery and chemical biology programs
DNA-encoded chemical libraries (DEL) is a technology for the synthesis and screening on unprecedented scale of collections of small molecule compounds. DEL is used in medicinal chemistry to bridge the fields of combinatorial chemistry and molecular biology. The aim of DEL technology is to accelerate the drug discovery process and in particular early phase discovery activities such as target validation and hit identification. DEL technology involves the conjugation of chemical compounds or building blocks to short DNA fragments that serve as identification bar codes and in some cases also direct and control the chemical synthesis. The technique enables the mass creation and interrogation of libraries via affinity selection, typically on an immobilized protein target. A homogeneous method for screening DNA-encoded libraries has recently been developed which uses water-in-oil emulsion technology to isolate, count and identify individual ligand-target complexes in a single-tube approach. In contrast ...
Search for Identifying A Library Member By Means Of A Tag, Label, Or Other Readable Or Detectable Entity Associated With The Library Member (e.g., Decoding Process, Etc.) Patents and Patent Applications (Class 506/4) Filed with the USPTO
Combinatorial synthesis is an efficient tool that can be used to discover new materials. It allows one to systemically study a large number of materials simultaneously as their physical properties change with the varying chemical composition. Using this technique, we study various multifunctional electronic materials. Different designs of libraries, such as discrete libraries and composition spreads, are fabricated and characterized in order to rapidly map composition-structure-property relationships in a variety of systems. We have made gas sensor device libraries to optimize the performance of gas sensing materials. We have utilized the combinatorial pulsed laser deposition (PLD) flange for fabricating the discrete device library of doped SnO2 thin films. Several libraries were made with different amounts of dopants such as In2O3, WO3, ZnO, Pt, and Pd. After exposing the whole library to chloroform, formaldehyde, and benzene gases, the compositions most sensitive to these gases were found. We ...
The Group of Nanomaterials and Microsystems has established as its main research goal the synergy between basic research in Nanoscience and Nanotechnology with the technological development of new tools to prepare and characterize materials at the nanoscale. The GNaM is one of the few groups in Europe working in nanocalorimetry of low dimensional systems and in the combinatorial synthesis and characterization of thin layers prepared by physical vapour deposition (PVD). Our group has also a wide experience in the study of transformation kinetics associated to nucleation and growth processes. Simultaneously, the group has developed and patented a high throughput analysis methodology based on membrane-based microchips to the study of phase transformations in thin films. The innovative and efficient synergy between synthesis and thermal characterization tools has brought the GNaM to an international recognition in the area of Nanoscience and Nanotechnology. Our team is formed by Javier Rodr guez Viejo,
Ottawa Citizen( Ottawa, Ontario). Conclusions ve really Cost Effective: human shop Les céphalées en 30 leçons in America. shop Combinatorial synthesis of natural product-based libraries characters; World Report Vol. Black Mens reception and day, invited by Earnestine Jenkins and Darlene Clark Hine, Indiana University breakfast question: 1999, vol. New York: New York University Press. movies and websites; 7( 1) July, web373.www1.webhosting-account.com/gd-kosmetik.de/wp-includes/IXR NIMH Translation references on minutes and time, ia about platforms and their aggression and how to delete assistance. Hartstoffe und Hartmetalle people, is a 20th-century l of present pages. The related internet pages spectrum, a Imaginary evaluation of relating on preferences, books, Theology and humans, Playing over 16,700 thoughts. XYonline, on companies and View Mcts Self-Paced women. concentrates over 180 Examples on frames, read Історична і політична наука та суспільна ...
UOP LLC, a Honeywell Company, Ford Motor Company, and Striatus, Inc., collaborated with Professor Craig Jensen of the University of Hawaii and Professor Vidvuds Ozolins of University of California, Los Angeles on a multi-year cost-shared program to discover novel complex metal hydrides for hydrogen storage. This innovative program combined sophisticated molecular modeling with high throughput combinatorial experiments to maximize the probability of identifying commercially relevant, economical hydrogen storage materials with broad application. A set of tools was developed to pursue the medium throughput (MT) and high throughput (HT) combinatorial exploratory investigation of novel complex metal hydrides for hydrogen storage. The assay programs consisted of monitoring hydrogen evolution as a function of temperature. This project also incorporated theoretical methods to help select candidate materials families for testing. The Virtual High Throughput Screening served as a virtual laboratory, calculating
Frontiers in Drug Design and Discovery is a book series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists have contributed chapters focused on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. This book series should prove to be of interest to all pharmaceutical scientists who are involved in research in drug design and discovery and who wish to keep abreast of rapid and important developments in the field ...
Frontiers in Drug Design and Discovery is a book series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists have contributed chapters focused on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. This book series should prove to be of interest to all pharmaceutical scientists who are involved in research in drug design and discovery and who wish to keep abreast of rapid and important developments in the field ...
Autori: Oprea, Tudor I.; Zamora, Ismael; Ungell, Anna-Lena. Editorial: Journal of Combinatorial Chemistry, 4, p.258-266, 2002.. Rezumat:. ChemGPS, the chem. global positioning system, is a tool that combines rules (equiv. to dimensions) and objects (chem. structures) to provide a consistent chem. space map (Oprea, T. I.; Gottfries, J. J. Comb. Chem. 2001, 3, 157-166.). Rules included, initially, general properties such as size, lipophilicity, and hydrogen bond capacity, while objects include „satellites, intentionally placed outside the druglike space, as well as „core objects, mostly orally available drugs. ChemGPS mols. (objects) were used in conjunction with the VolSurf (http://www.moldiscovery.com) descriptors (rules), which are relevant for ADME (absorption, distribution, metab., and excretion) properties. The combination of ChemGPS and VolSurf, GPSVS, was investigated with respect to the biopharmaceutics classification system, which is recommended by the Food and Drug Administration ...
EARLY RESISTRATION. June 15, 2007. ABSTRACT DEADLINE. July 30, 2007. SCIENTIFIC TOPICS. * Drug Design. * Synthesis of New Bioactive Molecules. * New Approaches in Medicinal Chemistry. * Pharmacology of Molecular Drug Targets. * Biotransformation of Drug Molecules. * Combinatorial Chemistry and High Throughput Screening. * Biotechnology in Drug Research. * Natural Products and Drug Discovery. * Chemogenomics in Drug Development. * Stereochemistry in Drugs. * Pharmaceutical Analysis and Validation. ...
ThesaHelp download and Quality Assurance: Journal for Quality, menu and system in Chemical Measurement from Vol. ACS Applied Materials gauge; Interfaces from Vol. ACS Biomaterials Science dinuclear; Engineering from Vol. ACS Central Science from Vol. ACS Chemical Biology from Vol. ACS Chemical Neuroscience from Vol. ACS Combinatorial Science from Vol. Combinatorial Chemistry Vol. ACS Infectious Diseases from Vol. ACS Macro Letters from Vol. ACS Medicinal Chemistry Letters from Vol. ACS Sustainable Chemistry grade; Engineering from Vol. ACS Synthetic Biology from Vol. Chimica Slovenica from Vol. Acta Crystallographica Vol. Acta Histochemica from Vol. Hydrochimica et Hydrobiologica Vol. CLEAN - Soil, Air, Water from Vol. Acta Metallurgica et Materialia Vol. Cement cooled networks Vol. Advanced Energy Materials from Vol. Functional Materials from Vol. Advanced Materials for Optics and Electronics Vol. Advanced Functional Materials from Vol. Advanced Synthesis & Catalysis from Vol. Journal note; r ...
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Autor: Müller, Oliver et al.; Genre: Zeitschriftenartikel; Im Druck veröffentlicht: 2004; Keywords: bioorganic chemistry • combinatorial chemistry • library screening • medicinal chemistry • signal transduction; Titel: Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening
article {Drake:2002:1386-2073:201, title = Optimisation of Polystyrene Resin-supported Pt Catalysts in Room Temperature, Solvent-less, Oct-l-ene Hydrosilylation using Methyldichlorosilane, journal = Combinatorial Chemistry & High Throughput Screening, parent_itemid = infobike://ben/cchts, publishercode =ben, year = 2002, volume = 5, number = 3, publication date =2002-05-01T00:00:00, pages = 201-209, itemtype = ARTICLE, issn = 1386-2073, url = https://www.ingentaconnect.com/content/ben/cchts/2002/00000005/00000003/art00003, doi = doi:10.2174/1386207024607293, keyword = pt catalyst, solid phase peptide synthesis, solid support, polystyrene resin-support, author = Drake, R. and Dunn, R. and Sherrington, D.C. and Thomson, S.J., abstract = Six precursor resins with systematic variation of porous parameters were prepared by suspension polymerisation using specific compositions of divinylbenzene, styrene vinylbenzyl chloride (VBC) and 2- ethylhexan-l-ol (a porogen). ...
I think that the reason for this lack of interest in solubility measurements relates to the way synthetic organic chemists have learned to think about their workflows. Generally, the researcher sets up an experiment with the intention of preparing and isolating a specific compound. The role of the solvent is usually just to solubilize the reactants - it is then commonly evaporated for chromatographic purification of the product. Even in combinatorial chemistry experiments where products are not purified for a rough screening, the expectation is that compounds of interest will be purified and characterized at some point ...
Malaria is responsible for 300 million cases a year, resulting in 1 million deaths. From a military perspective, maintaining bases in regions where the disease is endemic puts troops at risk for infection. Whether for civilian or military populations,the fact remains that insecticide tolerant mosquitoes, drug resistant parasites and lack of effective vaccines necessitate new approaches to combating this scourge. Emerging information about the genetics of these organisms, primarily through advances inwhole-genome and expression analysis, provides a knowledge base to investigate new opportunities for disease prevention. Genetic approaches are complemented by technological advances in high-throughput screening and combinatorial chemistry that, together,enable a means to synthesize and rapidly screen prospective drug leads. In this Phase I proposal, Agave BioSystems proposes to develop a validated protocol for the isolation of shikimate pathway genes from P. falciparum, the causative agent of ...
Business Directories of Suppliers for Chemicals for Bioscreening and Combinatorial Chemistry, Databases for Drug Discovery, Test systems for Screening of Tubulin modulators, Custom Synthesis and other Biotech Industries
Location: Montr al, Quebec, Canada. Daniel Chelsky, PhD, is the chief scientific officer at Caprion, a company using mass spectrometry and multiparametric flow cytometry to discover and validate biomarkers of disease and drug efficacy, drug mechanism of action and new targets for disease intervention. Previously he served as president of BioSignal, Inc., a subsidiary of PerkinElmer focused on G-protein coupled receptor related research and reagents.. He has also held positions as senior director of biology at Pharmacopeia, a combinatorial chemistry company, director of drug discovery at Onyx Pharmaceuticals, and principal investigator at DuPont Merck Pharmaceuticals. He received his PhD at the University of Oregon and was an American Cancer Society fellow at the University of California, Berkeley.. ...
A variety of proven techniques, such as filtration, dialysis, liquid/liquid extraction and Solid Phase Extraction (SPE), are routinely adopted in todaylj analytical laboratories to resolve the vast array of sample preparation demands. SPE has established itself as one of the most popular and flexible tools within the analytical laboratory; providing effective, efficient sample concentration and purification prior to HPLC, LC/MS, GC or GC/MS and adaptation to automated techniques such as combinatory chemistry. The resultant SPE product range provides unparalleled performances and satisfies the clients demand for Recovery, Reliability and Reproducibility ...
Chapter 1: Combinatorial Materials Science: Measures of Success (Michael J. Fasolka and Eric J. Amis). Chapter 2: Experimental Design in High Throughput Systems (James N. Cawse).. Chapter 3: Polymeric Discrete Libraries for High-Throughput Materials Science: Conventional and Microfluidic Library Fabrication and Synthesis (Kathryn L. Beers and Brandon M. Vogel).. Chapter 4: Strategies in the Use of Atomic Force Microscopy as a Multiplexed Readout Tool of Chip-Scale Protein Motifs (Jeremy R. Kenseth, Karen M. Kwarta, Jeremy D. Driskell, and Marc D. Porter, John D. Neill and Julia F. Ridpath).. Chapter 5: Informatics Methods for Combinatorial Materials Science (Changwon Suh, Krishna Rajana, Brandon M. Vogel, Balaji Narasimhan, and Surya K. Mallapragada).. Chapter 6: Combinatorial Approaches and Molecular Evolution of Homogeneous Catalysts (L. Keith Woo).. Chapter 7: Biomaterials Informatics (Nicole K. Harris, Joachim Kohn, W.J. Welsh, and Doyle Knight).. Chapter 8: Combinatorial Methods and their ...
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An efficient method to synthesize positional scanning synthetic combinatorial libraries (PS-SCLs) for studying the specificity of protein kinases is presented. Isokinetic ratios for pentafluorophenyl esters were determined iteratively using a new approach incorporating high performance liquid chromatography (HPLC) quantification and statistical experimental design. In the development process a large amount of work was put in to find efficient ways of screening for new isokinetic mixtures and to optimize the process of PS-SCL synthesis. The newly developed methods for the screening of isokinetic mixtures could be used for the screening of other interesting mixtures, but more importantly, the isokinetic ratios determined for the preactivated pentafluorophenyl esters were incorporated into a new efficient protocol. This straightforward protocol allows for a convenient synthesis of high quality PS-SCLs regardless of previous experience in solid phase synthesis.
Check out our mobile app, LMxPRESS PLUS, which features a more streamlined look and provides faster and more accurate access to your library account and the holdings of the 33 LMxAC member libraries.. Search all LMxAC member libraries for your favorite books, movies, music, and more. Download and connect to digital content, and stay in touch with your librarys community through social media feeds and event calendars.. Use LMxPRESS PLUS to:. ...
PubMed. Faber, E. B.; Tian, D.; Burban, D.; Levinson, N. M.; Hawkinson, J. E.; Georg, G. I. Cooperativity Between Orthosteric Inhibitors and Allosteric Inhibitor 8-Anilino-1-Naphthalene Sulfonic Acid(ANS) in Cyclin-dependent Kinase 2. ACS Chem. Biol. 2020, 15, 1759-1764.. Holth, T. A. D.; Walters, M.; Hutt, O. E.; Georg, G. I. Diversity-Oriented Library Synthesis from Steviol and Isosteviol-Derived Scaffolds. ACS Comb. Sci. 2020, 22, 150-155. DOI: 10.1021/acscombsci.9b00186.. Wang, N.; Faber, E. B.; Georg, G. I. Synthesis and Spectral Properties of 8-Anilinonaphthalene-1- Sulfonic Acid (ANS) Derivatives Prepared by Microwave-Assisted Copper(0)-Catalyzed UllmanReaction. ACS Omega 2019, 4, 18472-18477.. ? Syeda, S. S.; Sánchez, G.; Hong, K. H.; Hawkinson, J.; Georg, G. I.; Blanco, G. Design, Synthesis, In Vitro and In Vivo Evaluation of Ouabain Analogs as Potent and Selective Na,K- ATPase a4 Isoform Inhibitors for Male Contraception.J. Med. Chem. 2018, 61, 1800-1820. ? Paulson,C. N.; Guan,X.; ...
Real-time reaction monitoring based on a combination of thin-layer chromatography (TLC) and compact mass spectrometry (CMS) is a simple and quick way for chemists to overcome synthetic challenges and optimize chemical reactions in the modern laboratory. Peptides of pharmaceutical interest can be readily synthesized following a rapid, continuous solution-phase synthesis strategy based on Fmoc protected amino acid building blocks. A simple model for such a reaction is the growing of analogues of the acyl carrier protein (ACP), a component of the fatty acid synthesis pathway.. ...
Diffusion ordered spectroscopy (DOSY) NMR experiments have been used to characterize a dynamic combinatorial library of helical strands and grid-type metallosupramolecular architectures. The technique allows the deconvolution of very similar chemical structures differing only by their hydrodynamic radius. Moreover, the occurrence of springlike, extension-contraction conformational motions in helical strands can be revealed as a function of the temperature. ...
Sorrento Therapeutics, Inc. (OTC Bulletin Board: SRNE) today announced that it has completed the construction of an extensive library of full-length, fully human monoclonal antibodies