TY - JOUR. T1 - Recombinant human macrophage colony-stimulating factor in nonhuman primates. T2 - Selective expansion of a CD16+ monocyte subset with phenotypic similarity to primate natural killer cells. AU - Munn, David H.. AU - Bree, Andrea G.. AU - Beall, Arthur C.. AU - Kaviani, Michelle D.. AU - Sabio, Hernan. AU - Schaub, Robert G.. AU - Alpaugh, R. Katherine. AU - Weiner, Louis M.. AU - Goldman, Samuel J.. PY - 1996/8/15. Y1 - 1996/8/15. N2 - The CD16 receptor (FcγR-III) is found on many tissue macrophages (Mφs), but its expression on circulating monocytes is restricted to a small, phenotypically distinct subset. The number of these CD16+ monocytes may be markedly increased in response to sepsis, human immunodeficiency virus infection, or metastatic malignancy. We have recently shown that the CD16+ monocyte population is selectively expanded by administration of recombinant human macrophage colony-stimulating factor (rhM-CSF). In the current study, we used the highly rhM-CSF-responsive ...

Find information on Sargramostim (Leukine, rHu GM-CSF - recombinant human granulocyte/macrophage colony-stimulating factor) in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.

TY - JOUR. T1 - Effects of recombinant human granulocyte-macrophage colony-stimulating factor on myelosuppression induced by multiple cycles of high-dose chemotherapy in patients with advanced breast cancer. AU - Hoekman, Klaas. AU - Wagstaff, John. AU - Van Groeningen, Cees J.. AU - Vermorken, Jan B.. AU - Boven, Epie. AU - Pinedo, Herbert M.. PY - 1991/11/6. Y1 - 1991/11/6. N2 - In this study, 18 patients with advanced breast cancer were treated with multiple cycles of doxorubicin (75 or 90 mg/m2) plus cyclophosphamide (750 or 1000 mg/m2) every 21 days. Granulocyte-macrophage colony-stimulating factor (GM-CSF) (250 μg/m2 per day) was administered by continuous infusion during 10 days (days 2-12), starting in the first or second cycle of chemotherapy. Sixteen (89%) of 18 patients (95% confidence interval, 65%-99%) achieved an objective remission, five (28%) of which were complete. The median duration of response was 7 months. When GM-CSF was used for the first time, it had an effect on the ...

TY - JOUR. T1 - Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. AU - Dranoff, Glenn. AU - Jaffee, Elizabeth. AU - Lazenby, Audrey. AU - Golumbek, Paul. AU - Levitsky, Hyam. AU - Brose, Katja. AU - Jackson, Valerie. AU - Hamada, Hirofumi. AU - Pardoll, Drew. AU - Mulligan, Richard C.. PY - 1993/4/15. Y1 - 1993/4/15. N2 - To compare the ability of different cytokines and other molecules to enhance the immunogenicity of tumor cells, we generated 10 retroviruses encoding potential immunomodulators and studied the vaccination properties of murine tumor cells transduced by the viruses. Using a B16 melanoma model, in which irradiated tumor cells alone do not stimulate significant anti-tumor immunity, we found that irradiated tumor cells expressing murine granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulated potent, long-lasting, and specific anti-tumor ...

TY - JOUR. T1 - Murine granulocyte-macrophage colony-stimulating factor expressed from a bicistronic simian immunodeficiency virus-based integrase-defective lentiviral vector does not enhance T-cell responses in mice. AU - Michelini, Zuleika. AU - Negri, Donatella. AU - Biava, Mirella. AU - Baroncelli, Silvia. AU - Spada, Massimo. AU - Leone, Pasqualina. AU - Bona, Roberta. AU - Blasi, Maria. AU - Nègre, Didier. AU - Klotman, Mary E.. AU - Cara, Andrea. PY - 2014/12/1. Y1 - 2014/12/1. N2 - As a prelude to immunization studies in nonhuman primates, we compared in mice the immunogenicity of a simian immunodeficiency virus (SIV)-based integrase (IN)-defective lentiviral vector (IDLV) encoding the model antigen-enhanced green fluorescence protein (eGFP) in the presence or absence of the murine granulocyte-macrophage colony-stimulating factor (mGM-CSF) expressed from an internal ribosomal entry site (IRES) sequence. BALB/c mice were immunized once intramuscularly with IDLV expressing eGFP alone or ...

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Granulocyte-macrophage colony-stimulating factor (GM-CSF) is active in enhancing the production of mature myeloid cells in vitro and several phase 1/11 clinical trials have suggested that its administration may accelerate neutrophil recovery after autologous bone marrow transplantation (ABMT). We have conducted a multicentre randomized double-blind placebo controlled trial in patients with poor prognosis malignant lymphoma receiving an identical high-dose combination chemotherapy regimen with ABMT. 61 patients were entered and 29 in each arm of the trial were evaluated. Treatment with GM-CSF did not affect the period of severe neutropenia (absolute neutrophil count (ANC) of , 0.1 x 10(9)/l) but accelerated recovery to an ANC of 0.5 x 10(9)/l (median 14 d v 20 d in controls, P = 0.001).There was no significant difference in platelet recovery between the groups (GM-CSF group platelet dependent for 25 d v control 19 d, P = NS). The number of positive blood cultures was similar in both groups ...

Effectiveness of recombinant human granulocyte macrophage colony-stimulating issue for treating deep second-degree burns: a scientific evaluation and meta-analysis. Its unsure whether or not remedy by recombinant human granulocyte macrophage colony-stimulating issue (rhGM-CSF) can promote therapeutic of deep second-degree burns. This meta-analysis aimed to systematically evaluation and assess randomised managed trials (RCTs) that investigated the efficacy and security of rhGM-CSF for treating deep second-degree burns. This meta-analysis conformed […]. ...

This randomized clinical trial examines the effect of recombinant human granulocyte colony-stimulating factor on peripheral blood leukocyte and lymphocyte cell

TY - JOUR. T1 - Effects of Granulocyte-Macrophage Colony-Stimulating Factor on Neuronal Senescence in Ultraviolet Irradiated Skin. AU - Moon, Kyung Chul. AU - Lee, Hyun Su. AU - Son, Seung Tae. AU - Lee, Jae Sun. AU - Dhong, Eun-Sang. AU - Jeong, Seong-Ho. AU - Han, Seung-Kyu. PY - 2019/5/1. Y1 - 2019/5/1. N2 - Ultraviolet (UV) irradiation affects neuronal structures of the skin and accelerates skin aging. Cytokine cascades in keratinocytes after UV irradiation may result in a paracrine inhibitory effect on nerve cells. The purpose of the present study was to determine the direct effect of cytokines induced by UV radiation on nerve cells in terms of neuronal senescence. Our group performed a preliminary study to determine cytokines induced in UV-irradiated keratinocytes. Among 40 cytokines studied, granulocyte-macrophage colony-stimulating factor (GM-CSF) was increased 4-fold in inflammation antibody array. The GM-CSF was added to cultured human neuroblastoma cells. To evaluate the effect of ...

Abstract. Recombinant human granulocyte colony-stimulating factor (rhG-CSF) enhanced superoxide release and membrane depolarization in parallel in human granulo

TY - JOUR. T1 - Effect of ovine granulocyte-macrophage colony-stimulating factor on bovine in vitro embryo development and blastocyst interferon-s secretion. AU - Hickman, CF. AU - Ainslie, A. AU - Ealy, AD. AU - Ashworth, CJ. AU - Rooke, JA. N1 - 621723. PY - 2011. Y1 - 2011. KW - Blastocyst. KW - Bovine. KW - Development. KW - Effect. KW - Embryo. KW - Factor. KW - In Vitro. KW - Ovine. KW - Secretion. M3 - Article. VL - 46. SP - 608. EP - 615. JO - Reproduction in Domestic Animals. JF - Reproduction in Domestic Animals. SN - 0936-6768. ER - ...

Objective: The aim of the study is to investigate the effectiveness of the controlled slow-release granulocyte-monocyte colony-stimulating factor (GM-CSF) system in burn wound healing. ...

Cells and reagents. The cell lines used in this study were obtained from the American Type Culture Collection or the DSMZ. The MM.1S and MM.1R cell lines were a kind gift of Dr. Steven Rosen (Northwestern University, Chicago, IL). Cells were maintained in RPMI 1640 (Life Technologies, Inc.) supplemented with 10% fetal bovine serum. CD70 expression was quantified using the murine anti-CD70 antibody clone 1F6 and a Dako QiFi KiT flow cytometric indirect immunofluorescence assay (Dako). Monocyte-derived macrophages were prepared by culturing adherent leukocytes in 500 units/mL recombinant human granulocyte macrophage colony-stimulating factor (PeproTech) for 10 to 15 days as previously described (25). Cells recovered from these cultures were CD3/CD19 negative and expressed CD14, CD11b, CD16, CD32, and CD64 as determined by flow cytometry. Macrophage and T- and B-cell-specific fluorochrome-conjugated antibodies were purchased from BD Biosciences. CD138- and CD70-specific phycoerythrin-conjugated ...

To evaluate the safety of repeated courses of sargramostim ( recombinant granulocyte-macrophage colony-stimulating factor; GM-CSF ) administered subcutaneously to patients with HIV infection and leukopenia. To determine if administration of GM-CSF will prevent some or all of the hematologic toxicity associated with zidovudine ( AZT ) treatment in patients with pre-existing leukopenia. To assess any clinical and/or virologic benefits from administering alternating weeks of GM-CSF and AZT to patients with symptomatic HIV infection who have a history of cytologically confirmed Pneumocystis carinii pneumonia ( PCP ) or a circulating absolute CD4 lymphocyte count less than 200 cells/mm3 ...

Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor is produced by our Yeast expression system and the target gene encoding Ala18-Glu144 is expressed.

The gene IL-3 encodes interleukin 3, a hematopoietic colony-stimulating factor (CSF) that is capable of supporting the proliferation of a broad range of hematopoietic cell types. By using somatic cell hybrids and in situ chromosomal hybridization, we localized this gene to human chromosome 5 at bands q23-31, a chromosomal region that is frequently deleted [del(5q)] in patients with myeloid disorders. By in situ hybridization, IL-3 was found to be deleted in the 5q-chromosome of one patient with refractory anemia who had a del(5)(q15q33.3), of three patients with refractory anemia (two patients) or acute nonlymphocytic leukemia (ANLL) de novo who had a similar distal breakpoint [del(5)(q13q33.3)], and of a fifth patient, with therapy-related ANLL, who had a similar distal breakpoint in band q33 [del(5)(q14q33.3)]. Southern blot analysis of somatic cell hybrids retaining the normal or the deleted chromosome 5 from two patients with the refractory anemia 5q- syndrome indicated that IL-3 sequences were

TY - JOUR. T1 - The Effects of Oxidizing Species Derived from Molecular Oxygen on the Proliferation In Vitro of Human Granulocyte‐Macrophage Progenitor Cells. AU - BROXMEYER, HAL E.. AU - COOPER, SCOTT. AU - GABIC, THEODORE. PY - 1989/5. Y1 - 1989/5. N2 - In order to better understand the enhancing effects of lowered oxygen (O2) tension on the growth in vitro of granulocyte-macrophage progenitor cells (CFU-GM), the effects of oxidizing species derived from molecular O2 were assessed on CFU-GM. Low density or nonadherent low density normal human bone marrow cells were plated at ambient (20%) or lowered (5%) O2 tension in the presence of a source of colony stimulating factors, and in the absence or presence of superoxide dismutase, catalase, glucose oxidase or horseradish peroxidase, alone or in various combinations. Enhanced colony and cluster formation of CFU-GM was noted when low density cells were grown at 5% O2, or when cells were grown at 20% O2 in the presence of superoxide dismutase or ...

The magnitude of blindness and low vision in this oil what is cialis rich Ozoro community in Delta State is high and majority are avoidable causes of blindness. In contrast, temperate and tropical stoneflies exhibited similar acclimation responses. Subjects in Group A were equally divided into A1 (500 mg single bolus injection) and A2 (500 mg split dose).. Escalated MVAC with or without recombinant human granulocyte-macrophage colony-stimulating factor for the initial treatment of advanced malignant urothelial tumors: results of a randomized trial. Central to the system is an infuse-withdraw micropump component that, unlike previous micropump-based systems, has fully integrated drug and fluid storage compartments. Upon electrophoresis on denaturating gels, ribosomal RNA fraction of H.. We conducted a randomized, blinded crossover study of aldosterone vs vehicle and compared the effects of a low-sodium versus a high-sodium diet. Performance prediction of a synchronization link for distributed ...

PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

To assess the safety and efficacy of subcutaneous sargramostim ( granulocyte-macrophage colony-stimulating factor; GM-CSF ) in increasing and maintaining the granulocyte count in HIV-infected children who have developed granulocytopenia as a result of continuous intravenous ( CIV ) zidovudine ( AZT ). To assess the short-term and long-term effects of concomitant GM-CSF on other hematologic parameters. To assess the potential therapeutic benefit of concomitant GM-CSF and AZT on the natural history of HIV infection and associated infectious complications ...

Murine sarcoma MC12 cells were transfected with the gene coding for murine granulocyte-macrophage colony-stimulating factor (GM-CSF). Tumorigenicity of a variety of cell clones with different expression of the inserted gene was assessed. All of the genetically manipulated MC12 cell clones examined were found to be less tumorigenic than the parental MC12 cell population. No correlation was observed between the production of GM-CSF by the clones and their tumorigenicity. It has been found that irradiation of the GM-CSF-producing cells with the dose of 150 Gy did not significantly inhibit the GM-CSF production during the period of 5 days after irradiation. These findings provided us with the rationale for using the irradiated GM-CSF-producing MC12 sarcoma vaccine for therapy. It has further been found than immunosensitivity of the genetically manipulated, GM-CSF-producing tumour targets to the IL-2-activated killer (LAK) cell-mediated cytolysis was significantly increased, as compared to the ...

Human colony-stimulating factor 1 receptor (hCSF-1R) is unique among the hematopoietic receptors because it is activated by two distinct cytokines, CSF-1 and interleukin-34 (IL-34). Despite ever-growing insights into the central role of hCSF-1R signaling in innate and adaptive immunity, inflammatory diseases, and cancer, the structural basis of the functional dichotomy of hCSF-1R has remained elusive. Here, we report crystal structures of ternary complexes between hCSF-1 and hCSF-1R, including their complete extracellular assembly, and propose a mechanism for the cooperative human CSF-1:CSF-1R complex that relies on the adoption by dimeric hCSF-1 of an active conformational state and homotypic receptor interactions. Furthermore, we trace the cytokine-binding duality of hCSF-1R to a limited set of conserved interactions mediated by functionally equivalent residues on CSF-1 and IL-34 that play into the geometric requirements of hCSF-1R activation, and map the possible mechanistic consequences of ...

In this study, hematopoietic cells from mice pretreated with CVE and exposed to acute cold/restraint stress were stimulated in the presence of growth factors to form colonies, thus providing accurate information about the modulation of the green algae of the stress-induced changes in the hematopoietic response. Our results demonstrated that exposure to acute stress affected hematopoiesis. Mice exposed for a 2.5-hour time period of cold and restraint presented diminished clonal capacity for CFU-GM content per femur, which was decreased by as much as 50% compared with that in control mice, in spite of the significant increase in serum colony-stimulating activity (CSA). Treatment with 50 mg/kg CVE for 5 days, previously to the stress regimen, attenuates the effects of the stress, since comparable levels of myeloid progenitors were found in the bone marrow of both CVE/stress and control mice. Moreover, the sera from stressed mice pretreated with CVE further increased the CFU-GM formation. On the ...

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Savara Pharmaceuticals (previously Serendex Pharmaceuticals) is developing an inhaled formulation of molgramostim, a recombinant human granulocyte macrophage

TY - JOUR. T1 - Proliferation and maturation effects of in-vivo granulocyte-macrophage colony stimulating factor in acute non-lymphocyte luekaemia. AU - Damiani, D.. AU - Michieli, M.. AU - Revignas, M. G.. AU - Russo, D.. AU - Fanin, R.. AU - Michelutti, A.. AU - Mallardi, F.. AU - Baccarani, M.. PY - 1992. Y1 - 1992. UR - http://www.scopus.com/inward/record.url?scp=0026574360&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0026574360&partnerID=8YFLogxK. M3 - Article. C2 - 1398278. AN - SCOPUS:0026574360. VL - 77. SP - 25. EP - 29. JO - Haematologica. JF - Haematologica. SN - 0390-6078. IS - 1. ER - ...

GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages, and promotes the proliferation and development

TY - JOUR. T1 - Protective effect of recombinant murine granulocyte-macrophage colony-stimulating factor against Pseudomonas aeruginosa infection in leukocytopenic mice. AU - Tanaka, T.. AU - Okamura, S.. AU - Okada, K.. AU - Suga, A.. AU - Shimono, N.. AU - Ohhara, N.. AU - Hirota, Y.. AU - Sawae, Y.. AU - Niho, Y.. N1 - Copyright: Copyright 2004 Elsevier B.V., All rights reserved.. PY - 1989. Y1 - 1989. N2 - The effects of recombinant murine granulocyte-macrophage colony-stimulating factor (rmGM-CSF) against Pseudomonas aeruginosa infection in ICR mice were investigated. Mice were treated with cyclophosphamide (CPA) and were then injected intraperitoneally with rmGM-CSF three times daily, beginning on the day after CPA treatment, for 7 days. The number of peripheral blood leukocytes in both CPA- and rmGM-CSF-treated mice and control CPA-treated mice reached a nadir on day 4, when P. aeruginosa was injected intraperitoneally. The administration of rmGM-CSF significantly increased the proportion ...

TY - JOUR. T1 - Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryos expressing hGM-CSF receptors but not erythropoietin receptors. AU - Hisakawa, Hiroaki. AU - Sugiyama, Daisuke. AU - Nishijima, Ichiko. AU - Xu, Ming Jiang. AU - Wu, Hong. AU - Nakao, Kazuki. AU - Watanabe, Sumiko. AU - Katsuki, Motoya. AU - Asano, Shigetaka. AU - Aral, Ken Ichi. AU - Nakahata, Tatsutoshi. AU - Tsuji, Kohichiro. PY - 2001/12/15. Y1 - 2001/12/15. N2 - Although erythropoietin (EPO) and its receptor (EPOR) are crucial for the proliferation, survival, and terminal differentiation of erythroid progenitors, it remains to be elucidated whether EPOR-unique signaling is required for erythropoiesis. To address this issue, human granulocyte-macrophage colony-stimulating factor (hGM-CSF) receptor (hGMR)-transgenic mice and heterozygous EPOR mutant mice were crossed by in vitro fertilization. In methylcellulose clonal culture of fetal liver (FL) ...

Study Objective: To determine whether recombinant human granulocyte colony-stimulating factor (G-CSF) is effective in increasing neutrophil counts in patients with hairy cell leukemia and neutropenia.. Design: Open label, phase I/II study of G-CSF, given by daily subcutaneous injection for up to 7 weeks.. Setting: Outpatient oncology clinic of a university medical center.. Patients: A consecutive sample of four patients with hairy cell leukemia complicated by severe neutropenia. Three patients completed the study; one patient was removed after 2 weeks of therapy.. Interventions: Granulocyte colony-stimulating factor was given by daily subcutaneous injection. Each patient began therapy with 1 µg/kg body weight ·d; after 1 week the dose was increased to 3 µg/kg ·d, and 1 week later to 6 µg/ kg ·d. Therapy was continued for 5 to 6 weeks. Patients were taught self-injection, and administered treatment at home.. Measurements and main results: In three patients, an increase in absolute ...

TY - JOUR. T1 - Macrophage colony-stimulating factor in cooperation with transforming growth factor-β1 induces the differentiation of CD34+ hematopoietic progenitor cells into Langerhans cells under serum-free conditions without granulocyte-macrophage colony-stimulating factor. AU - Mollah, Zia U.A.. AU - Aiba, Setsuya. AU - Nakagawa, Satoshi. AU - Hara, Masahiro. AU - Manome, Hideaki. AU - Mizuashi, Masato. AU - Ootani, Tomoyuki. AU - Yoshino, Yumiko. AU - Tagami, Hachiro. PY - 2003/2/1. Y1 - 2003/2/1. N2 - Macrophage colony-stimulating factor has not been considered as a factor responsible for dendritic cell or Langerhans cell development from hematopoietic progenitor cells. In this study, we examined whether macrophage colony-stimulating factor could be used instead of granulocyte-macrophage colony-stimulating factor for the in vitro development of Langerhans cells from hematopoietic progenitor cells. We replaced granulocyte-macrophage colony-stimulating factor with macrophage ...

We show that cytotoxic T lymphocytes (CTLs) infiltrating a kidney tumor recognize a peptide encoded by an alternative open reading frame (ORF) of the macrophage colony-stimulating factor (M-CSF) gene. Remarkably, this alternative ORF, which is translated in many tumors concurrently with the major ORF, is also translated in some tissues that do not produce M-CSF, such as liver and kidney. Such a dissociation of the translation of two overlapping ORFs from the same gene is unexpected. The antigenic peptide encoded by the alternative ORF is presented by human histocompatibility leukocyte antigen (HLA)-B*3501 and has a length of 14 residues. Peptide elution indicated that tumor cells naturally present this 14 mer, which is the longest peptide known to be recognized by CTLs. Binding studies of peptide analogues suggest that it binds by its two extremities and bulges out of the HLA groove to compensate for its length.

Interleukin-3; Burst-Promoting Factor, Erythrocyte; Colony-Stimulating Factor, Mast-Cell; Colony-Stimulating Factor, Multipotential; Colony-Stimulating Factor 2 Alpha; Erythrocyte Burst-Promoting Factor; Multipotential Colony-Stimulating Factor; P-Cell Stimulating Factor; IL-3; Mast-Cell Colony-Stimulating Factor. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.

TY - JOUR. T1 - Pilot study of granulocyte-macrophage colony-stimulating factor and interleukin-2 as immune adjuvants for a melanoma peptide vaccine. AU - Block, Matthew S.. AU - Suman, Vera J.. AU - Nevala, Wendy K.. AU - Kottschade, Lisa A.. AU - Creagan, Edward T.. AU - Kaur, Judith S.. AU - Quevedo, Jorge Fernando. AU - McWilliams, Robert R.. AU - Markovic, Svetomir N.. PY - 2011/10/1. Y1 - 2011/10/1. N2 - Thus far, peptide vaccines used to stimulate tumor-specific immune responses in patients with melanoma have been largely unsuccessful. Granulocyte-macrophage colony-stimulating factor and interleukin-2 are immune-potentiating cytokines that have improved vaccine responses in preclinical models. We hypothesized that higher doses of granulocyte-macrophage colony-stimulating factor and addition of low-dose interleukin-2 might augment responses to vaccine antigens. Patients with resected stage II, III, or IV melanoma were treated with vaccines containing three melanoma-associated peptides ...

Fingerprint Dive into the research topics of Influence of filgrastim (granulocyte colony-stimulating factor) on human immunodeficiency virus type 1 RNA in patients with cytomegalovirus retinitis. Together they form a unique fingerprint. ...

Recombinant human granulocyte-macrophage colony stimulating factor (sargramostim) as an alternative therapy for fistulizing Crohns disease.

The mortality rate at eight weeks was similar in the lenograstim and placebo groups (23 and 27 percent, respectively; P = 0.60), as was the incidence of severe infections. The median duration of neutropenia (absolute neutrophil count , or = 1000 per cubic millimeter) was shorter in the lenograstim group (21 days, as compared with 27 days in the placebo group; P , 0.001). Eight percent of the patients in both groups had regrowth of AML cells. The rate of complete remission was significantly higher in the lenograstim group (70 percent, as compared with 47 percent in the placebo group; P = 0.002). Overall survival, however, was similar in the two groups (P = 0.76). Conclusions: ...

Definition of Colony-stimulating factors in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is Colony-stimulating factors? Meaning of Colony-stimulating factors as a legal term. What does Colony-stimulating factors mean in law?

Product Name: Mouse mAb anti- human Granulocyte Macrophage Colony Stimulating Factor (GM-CSF), Tracer (HRP Labeled), Clone 429Collection: AntibodySub Category:

Hemopoietic growth factors regulate the differentiation and proliferation of particular progenitor cells. Made available through recombinant DNA technology, they hold tremendous potential for medical uses when a persons natural ability to form blood cells is diminished or defective. Recombinant erythropoietin (EPO) is very effective in treating the diminished red blood cell production that accompanies end-stage kidney disease. Erythropoietin is a sialoglycoprotein hormone produced by peritubular cells of kidney Granulocyte-macrophage colony-stimulating factor and granulocyte CSF are given to stimulate white blood cell formation in cancer patients who are receiving chemotherapy, which tends to kill their red bone marrow cells as well as the cancer cells. Thrombopoietin shows great promise for preventing platelet depletion during chemotherapy. CSFs and thrombopoietin also improve the outcome of patients who receive bone marrow transplants. Colony-stimulating ...

Looking for colony-stimulating factor? Find out information about colony-stimulating factor. A group of lymphocytes that induce the maturation and proliferation of leukocyte, macrophage, and monocyte lines present in bone marrow Explanation of colony-stimulating factor

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is often used to treat leucopenia. Other haematopoietins may increase the number of circulating leucocytes with higher efficiency, but GM-CSF

Increased numbers of eosinophils and mast cells in the bronchial mucosa are characteristic features in subjects with aspirin-sensitive asthma. Interleukin-5 (IL-5) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are involved in the activation, maturation, and perpetuation of survival o …

Transgenic expression of granulocyte-macrophage colony-stimulating factor induces the differentiation and activation of a novel dendritic cell population in the lung Academic Article ...

An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages ...

cost. 2 Prophylactic use of recombinant human granulocyte colony-stimulating factors (G-CSFs), such as filgrastim or pegfilgrastim, can significantly reduce FN risk and FN-related costs. 3 - 5 The risk of developing FN depends on patient and disease. ...

TY - JOUR. T1 - Inhaled granulocyte-macrophage colony stimulating factor for first pulmonary recurrence of osteosarcoma. T2 - Effects on disease-free survival and immunomodulation. A report from the Childrens Oncology Group. AU - Arndt, Carola A.S.. AU - Koshkina, Nadya V.. AU - Inwards, Carrie Y.. AU - Hawkins, Douglas S.. AU - Krailo, Mark D.. AU - Villaluna, Doojduen. AU - Anderson, Peter M.. AU - Goorin, Allen M.. AU - Blakely, Martin L.. AU - Bernstein, Mark. AU - Bell, Sharon A.. AU - Ray, Kaylee. AU - Grendahl, Darryl C.. AU - Marina, Neyssa. AU - Kleinerman, Eugenie S.. PY - 2010/8/1. Y1 - 2010/8/1. N2 - Purpose: Osteosarcoma most commonly recurs in the lung. Based on preliminary data on the antitumor effects of granulocyte-macrophage colony stimulating factor (GM-CSF) in animal models, and promising phase I trials, we embarked on a feasibility study of inhaled GM-CSF in patients with first isolated pulmonary recurrence of osteosarcoma. Experimental Design: Forty-three eligible patients ...

Identification of the soluble granulocyte-macrophage colony stimulating factor receptor protein in vivo and development of a soluable model of the high affinity cell surface receptor for granulocyte-macrophage colony stimulating ...

M-CSF, also called CSF-1, is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells

T-helper cells producing interleukin (IL)-17A and IL-17F cytokines (Th17 cells) are considered the source of autoimmunity in rheumatoid arthritis (RA). In this study, we characterized specific pathogenic features of Th17 cells in RA. By using nano-string technology, we analyzed transcription of 419 genes in the peripheral blood CCR6(+)CXCR3(-) CD4(+) cells of 14 RA patients and 6 healthy controls and identified 109 genes discriminating Th17 cells of RA patients from the controls. Th17 cells of RA patients had an aggressive pathogenic profile and in addition to signature cytokines IL-17, IL-23 and IL-21, and transcriptional regulators RAR-related orphan receptor gamma of T cells (RORγt) and Janus kinase 2 (JAK2), they produced high levels of IL-23R, C-C chemokine ligand type 20 (CCL20), granulocyte-monocyte colony-stimulating factor (GM-CSF ) and transcription factor Tbet required for synovial homing ...

Granulocyte Macrophage Colony Stimulating Factor Market Insights: Global Industry Analysis, Market Drivers, Restraints, Opportunities, Applications, Trends And Forecasts 2020-2026

Production of neutralizing granulocyte-macrophage colony-stimulating (GM-CSF) antibodies in carcinoma patients followingGM-CSF combinaiton therapy. ...

49. Dillman R.O., Wiemann M., Nayak S.K. et al. Interferongamma or granulocyte-macrophage colony-stimulating factor administered as adjuvants with a vaccine of irradiated autologous tumor cells from short-term cell line cultures: a randomized phase 2 trial of the cancer biotherapy research group // J Immunother. - 2003. - Vol. 26, № 4. - Р. 367-373 ...

Several laboratories have developed culture systems that allow the generation of large numbers of human dendritic cells (DC) from monocytes using granulocyte-macrophage colony stimulating factor (GM-CSF), and interleukin-4 (IL-4). In this work we provided evidence that GM-CSF (100 ng/ml) in combination with a low concentration of IL-4 (5 ng/ml) was efficient in the generation of immature, non-adherent, monocyte-derived DC as the same concentration of GM-CSF, and ten times higher concentration of IL-4 (50 ng/ml). This conclusion was based on the similar phenotype profile of DC such as the expression of CD1a, CD80, CD86, and HLA-DR, down-regulation of CD14, and the absence of CD83, as well as on their similar allostimulatory activity for T cells. A higher number of cells remained adherent in cultures with lower concentrations of IL-4 than in cultures with higher concentrations of the cytokine. However, most of these adherent cells down-regulated CD14 and stimulated the proliferation of ...

The global protected feed amino acids market is expected to grow from USD 1,376.57 million 2017 to USD 2,120.57 million by the end of 2024 at a Compound Annual Growth Rate (CAGR) of 6.37%. Growing demand of Glutamic acid for enhancing flavoris one of the factors largely attributing to the growth of protected feed amino acids market globally The factors attributing to the growth of the market are growing demand of glutamic acid for enhancing flavor, need to control the rising human health issues, and increase demand for amino acid-based nutrition products. However, some factors such as high cost involved in r&d activities & production, and stringent regulations may hinder the market growth. The global protected feed amino acids market is expected to showcase the opportunities such as and growing demand in developing economies. In the near future, the market may face the possible challenges in the growth due to increasing usage of multi-page labeling, and negative perception of

Rabbit anti Human GM-CSF antibody recognizes human GM-CSF (granulocyte-macrophage colony-stimulating factor), a 14.6kDa haematopoietic gro

Miller, A M.; Page, P L.; Hartwell, B L.; and Robinson, S H., Inhibition of growth of normal murine granulocytes by cocultured acute leukemic cells. (1977). Subject Strain Bibliography 1977. 31 ...

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Selective expression of interleukin 10, interferon gamma, and granulocyte-macrophage colony-stimulating factor in ovarian cancer biopsies.: The variable clinica

Medical information for Granulocyte Macrophage Colony Stimulating Factor on Pediatric Oncall including Mechanism, Indication, Contraindications, Dosing, Adverse Effect, Interaction, Hepatic Dose.

Colony stimulating factors (CSFs) are proteins that stimulate production of immune (white blood) cells and provide life-saving protection against infection.