TY - JOUR. T1 - Waardenburg syndrome type IV De Novo SOX10 variant causing chronic intestinal Pseudo-Obstruction. AU - Hogan, Anthony R.. AU - Rao, Krishnamurti A.. AU - Thorson, Willa L.. AU - Neville, Holly L.. AU - Sola, Juan E.. AU - Perez, Eduardo A.. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Waardenburg syndrome (WS) type IV is characterized by pigmentary abnormalities, deafness and Hirschsprungs disease. This syndrome can be triggered by dysregulation of the SOX10 gene, which belongs to the SOX (SRY-related high-mobility group-box) family of genes. We discuss the first known case of a SOX10 frameshift mutation variant defined as c.895delC causing WS type IV without Hirschsprungs disease. This female patient of unrelated Kuwaiti parents, who tested negative for cystic fibrosis and Hirschsprungs disease, was born with meconium ileus and malrotation and had multiple surgical complications likely due to chronic intestinal pseudo-obstruction. These complications included small intestinal necrosis ...

Pseudo-obstruction is a syndrome characterized by signs and symptoms of a mechanical obstruction of the small or large bowel in the absence of an anatomic lesion that obstructs the flow of intestinal contents. Pseudo-obstruction may be acute or chron

Chronic intestinal pseudo-obstruction (CIPO) is an extremely rare condition with symptoms of recurrent intestinal obstruction without any lesions. The outcomes of pediatric CIPO and predictors for the outcomes have not yet been well established. We analyzed the clinical outcomes and associated factors for the outcomes of pediatric CIPO. We retrospectively reviewed 66 primary CIPO patients diagnosed between January 1985 and December 2017. We evaluated parenteral nutrition (PN) factors such as PN duration, PN use over 6 months, home PN, and mortality as outcomes. We selected onset age, presence of urologic symptoms, pathologic type, and involvement extent as predictors. The early-onset CIPO was found in 63.6%, and 21.2% of the patients presenting with urologic symptoms. Of the 66 patients, 47 and 11 had neuropathy and myopathy, respectively. The generalized involvement type accounted for 83.3% of the cases. At the last follow-up, 24.2% of the patients required home PN management. The mean duration of PN

Malignant pheochromocytoma associated with pseudo-obstruction of the colon. Murakami, Soichi; Okushiba, Shun-ichi; Ohno, Koichi; Ito, Kiyotaka; Satou, Kousaku; Sugiura, Hiroshi; Morikawa, Toshiaki; Furukawa, Koji; Kondo, Satoshi; Katoh, Hiroyuki; Nihei, Kazuyoshi // Journal of Gastroenterology;2003, Vol. 38 Issue 2, p175 Effective treatment has not yet been established for intestinal pseudo-obstruction, a rare complication of malignant pheochromocytoma. We report the case of a 41-year-old man who presented with malignant pheochromocytoma associated with pseudo-obstruction of the colon. His serum catecholamine... ...

The main treatment is nutritional support to prevent malnutrition and antibiotics to treat bacterial infections. Disorders that may coexist and worsen symptoms of pseudo-obstruction--such as gastroparesis (delayed stomach emptying), gastroesophageal reflux, or bacterial overgrowth--need to be identified and treated.. The challenges of treating chronic pseudo-obstruction are often multifaceted and involve the patient and family as well as the physician. The physician may suggest a multidisciplinary approach to treatment. A management team might include the childs pediatric gastroenterologist, a pediatric pain management specialist, a behavioral specialist, and others.. Chronic abdominal pain or the fear of pain is a common complaint in children with chronic intestinal pseudo-obstruction and may be treated with behavioral or relaxation therapy as well as with non-narcotic medicines.. Some children are able to benefit from small, frequent meals. Others are unable or unwilling to eat because of the ...

The term intestinal pseudo-obstruction denotes a syndrome characterized by a clinical picture suggestive of mechanical obstruction in the absence of any demonstrable evidence of such an obstruction in the intestine. On the basis of the clinical presentation, pseudo-obstruction syndromes can be divided into acute and chronic forms.

운동 기능의 저하는 넓게 분류해서 장 폐쇄 혹은 소장 무력증 혹은 마비 때문으로 나눌 수 있다. 하지만, 장 폐쇄의 증상이 있으면서 물리적인 장 폐쇄는 없는 경우가 있는데 이를 급성 대장성 거짓폐쇄증 (acute colonic pseudoobstruction), 또는 오길비 증후군 (Ogilvies syndrome)이라고 한다.. 장폐쇄 (bowel obstruction)는 위장관이 어떤 물리적인 요인으로 막한 것을 말한다.. 소장의 마비는 마비성 장폐색 (paralytic ileus)이라고 하는데, 완전 마비일 필요는 없으나 내용물이 이동하지 못해 장 폐색을 일으킬 정도로 운동 기능이 저하되어있어야한다. 마비성 장폐색은 특정 수술 후에 흔하게 발생하는 부작용으로, 이때는 수술 후 장폐색 (postsurgical ileus)이라고도 한다. 약이나 외상, 또는 질환 (급성 췌장염 (acute pancreatitis) 등) 역시 원인 중 하나다. 마비성 장폐색은 변비와 ...

CIIPS in children has been reported under a variety of names; megacystis-microcolon-intestinal hypoperistalsis syndrome, intestinal pseudo-obstruction, chronic adynamic ileus, pseudo-Hirschsprungs disease, adynamic bowel syndrome, colonic neuronal dysplasia, and hollow visceral myopathy.17-25 It is the result of a heterogeneous group of disorders of the enteric neuromusculature that cause severe intestinal dysmotility, resulting in functional obstruction.26-30 Analysis of published studies has shown that most patients develop symptoms early in life.31 In this series, 32 of 44 children developed symptoms during the 1st year of life. At birth they may present with obstruction of either the gut or urinary tract, or both. A persistent bilious aspirate can indicate an associated midgut malrotation. Later, the main presentation is with chronic constipation and/or abdominal distension associated with obstruction and episodic vomiting, which may be bile stained. Previous studies have either been of ...

Discussion Chronic intestinal pseudo-obstruction (CIPO) is a rare, severe syndrome with impaired gastro-intestinal motility leading to functional obstruction resembling mechanical obstruction. It usually affects elderly people with underlying co-morbidities, and early recognition and appropriate management are essential to reduce life-threatening complications.1 The condition may be idiopathic or secondary to other conditions. Most cases are sporadic. Familial forms with either dominant or recessive autosomal inheritance have been described. Histologically, it is classified into neuropathies, mesenchymopathies and myopathies, according to the predominant involvement of enteric neurons, interstitial cells of Cajal or smooth-muscle cells, respectively.2 Hollow visceral myopathy (HVM) is a myopathic cause of CIPO. HVM is a rare clinical entity characterised by impaired intestinal function and motility secondary to a smooth-muscle defect.3,4 Familial visceral myopathy is the most common type, with ...

O:13:\PanistOpenUrl\:36:{s:10:\\u0000*\u0000openUrl\;N;s:6:\\u0000*\u0000idc\;N;s:6:\\u0000*\u0000fmt\;s:7:\journal\;s:6:\\u0000*\u0000doi\;s:0:\\;s:6:\\u0000*\u0000pii\;s:0:\\;s:7:\\u0000*\u0000pmid\;s:0:\\;s:9:\\u0000*\u0000atitle\;s:148:\CHRONIC IDIOPATHIC INTESTINAL PSEUDO-OBSTRUCTION SYNDROME: RADIOLOGIC SIGNS IN CHILDREN WITH EMPHASIS ON DIFFERENTIATION FROM MECHANICAL OBSTRUCTION\;s:9:\\u0000*\u0000jtitle\;s:0:\\;s:9:\\u0000*\u0000stitle\;s:0:\\;s:7:\\u0000*\u0000date\;s:4:\1981\;s:9:\\u0000*\u0000volume\;s:0:\\;s:8:\\u0000*\u0000issue\;s:0:\\;s:8:\\u0000*\u0000spage\;s:0:\\;s:8:\\u0000*\u0000epage\;s:0:\\;s:8:\\u0000*\u0000pages\;s:0:\\;s:7:\\u0000*\u0000issn\;s:0:\\;s:8:\\u0000*\u0000eissn\;s:0:\\;s:9:\\u0000*\u0000aulast\;s:5:\BYRNE\;s:10:\\u0000*\u0000aufirst\;s:2:\WJ\;s:9:\\u0000*\u0000auinit\;N;s:10:\\u0000*\u0000auinitm\;N;s:5:\\u0000*\u0000au\;a:4:{i:0;s:8:\BYRNE WJ\;i:1;s:7:\CIPEL ...

Learn more about Intestinal Pseudo-obstruction at Atlanta Outpatient Surgery Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...

A clinicopathologic study was made of 16 patients with amyloidosis and with clinical signs of intestinal pseudo-obstruction. amyloid deposits in the small intestine were proved in all cases by endoscopic or intra-operative biopsies, and immunohistochemical study identified the chemical types of amyloid protein: amyloid A protein (AA) in 13 cases, light chain protein (AL) in two, and beta 2-microglobulin (AH) in one. Clinically, an acute self limiting obstructive condition was evident in 13 cases with AA, and 12 of them returned to normal bowel function after receiving total parenteral nutrition. Two cases with AL and one with AH presented chronic, intermittent, obstructive symptoms, and medical treatment, including total parenteral nutrition, was ineffective with no recovery of intestinal propulsion. Pathological examination of the necropsy specimens in seven cases showed considerable differences in the preferential sites of gastrointestinal deposits between the chemical types of amyloid; ...

Discusses chronic and acute forms of intestinal pseudo-obstruction and briefly describes symptoms, diagnosis, and treatment of this rare condition.

A collection of disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Intestinal pseudo-obstruction

Ogilvie syndrome is the acute dilation of the colon in the absence of any mechanical obstruction in severely ill patients. Colonic pseudo-obstruction is characterized by massive dilatation of the cecum (diameter > 10 cm) and right colon on abdominal X-ray. It is a type of megacolon, sometimes referred to as acute megacolon, to distinguish it from toxic megacolon. The condition carries the name of the British surgeon Sir William Heneage Ogilvie (pl) (1887-1971), who first reported it in 1948. Usually the patient has abdominal distention, pain and altered bowel movements. There may also be nausea and vomiting. Ogilvie syndrome may occur after surgery, especially following coronary artery bypass surgery and total joint replacement. Drugs that disturb colonic motility (e.g., anticholinergics or opioid analgesics) contribute to the development of this condition. The exact mechanism is not known. The probable explanation is imbalance in the regulation of colonic motor activity by the autonomic ...

Dr. Contreras responded: Labs and X-rays. First you have to make sure there arent any other causes of true obstruction. This is done with a combination of x-rays or scans, physical examination, review of the medical history, and laboratory tests. After other causes have been eliminated, then the patient is treated for pseudo-obstruction, also called ogilves syndrome.

Treatment. There is no specific treatment for individuals with CIP. Treatment is directed toward the specific symptoms that are apparent in each individual, and to support adequate nutritional needs. Treatment may require the coordinated efforts of a team of specialists. Pediatricians, pediatric gastroenterologists, surgeons, pain management specialists, psychologists, dietitians, and other healthcare professionals may need to systematically and comprehensively plan an affect individual's treatment.. The specific therapeutic procedures and interventions for individuals with CIP will vary, depending upon numerous factors including the specific symptoms present, the site and extent of the affected portion of the GI tract, an individual's age and overall health, tolerance of certain medications or procedures, personal preference and other factors. Decisions concerning the use of particular therapeutic interventions should be made by physicians and other members of the healthcare team in ...

Authors: G Ravenscroft, S Pannell, G OGrady, R Ong, HC Ee, F Faiz, L Marns, H Goel, P Kumarasinghe, E Sollis, P Sivadorai, M Wilson, A Magoffin, S Nightingale, M-L Freckmann, EP Kirk, R Sachdev, DA Lemberg, MB Delatycki, MA Kamm, C Basnayake, PJ Lamont, DJ Amor, K Jones, J Schilperoort, MR Davis, NG Laing

This cross sectional study has characterised the spectrum of clinical, pathological, and prognostic features of the syndrome of CIIP in adults attending a tertiary referral hospital. It was designed to give an overview of the condition which case reports cannot do, because of their focus on individual patients and their inherent bias in reporting unusual features. It demonstrates that in a specialised centre, using our diagnostic criteria, most patients have a visceral myopathy, with a prolonged but disabling course.. The condition of CIIP is rare. We do not believe that our patients are completely typical of affected patients in the community. However only a limited number of tertiary referral centres are likely to manage enough patients with this condition to enable a report such as this to be composed. Some patients will have a relatively benign course with limited symptoms and no need for nutritional supplementation, as occurred in some of the relatives of patient 14. Although this family ...

Andrews JM, Brierley SM, Blackshaw LA. Small intestinal motor and sensory function and dysfunction. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtrans Gastrointestinal and Liver Disease. 10th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 96.. Camilleri M. Disorders of gastrointestinal motility. In: Goldman L, Schafer AI, eds. Goldmans Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 136.. Fry RD, Mahmoud NN, Maron DJ, Bleier JIS. Colon and rectum. In: Townsend CM Jr, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Textbook of Surgery. 19th ed. Philadelphia, PA: Elsevier Saunders; 2012:chap 52. ...

Degenerative leiomyopathy (DL) is a distinctive form of acquired degenerative visceral myopathy of uncertain etiology that occurs largely in Africa and results in intestinal pseudo-obstruction (IP). In this review of 39 patients from the Western Cape region of South Africa, the mean age at presentation was 9.5 years (range 6 months to 16 years). Characteristic clinical features included a chronic, insidious history of repeated attacks of abdominal distension, abdominal pain, and vomiting. Marked gaseous distension with atony and IP, especially of the colon, was noted on X-ray films. Megacolon was the most common radiologic feature, but pseudo-obstruction extended proximally into the small intestine in some patients with advanced disease. In the majority of cases the condition was progressive and eventually affected the entire gastrointestinal (GI) tract. Histologic features included smooth-muscule degeneration with vacuolated cytoplasm, extracellular edema, and increased fibrosis of both ...

Approval date: Aug. 30,2012. 851199-59-2 CAS NO. L-Cysteinyl-L-cysteinyl-L-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-tyrosine cyclo(1-6),(2-10),(5-13)-tris(disulfide). Linaclotide is a peptide consisting of 14 amino acids. The sequence is. H-Cys1-Cys2-Glu3-Tyr4-Cys5-Cys6-Asn7-Pro8-Ala9-Cys10-Thr11-Gly12-Cys13-Tyr14-OH. There are three disulfide bonds: Between Cys1 and Cys6, between Cys2 and Cys10, and between Cys5 and Cys13.[8]. Linaclotide (marketed under the trade name Linzess) is an experimentalpeptide agonist of guanylate cyclase 2C that is undergoing clinical trials for use in treating abdominal pain in patients with irritable bowel syndrome (IBS) accompanied by constipation. The drug also looks promising in the treatment of gastroparesis, chronic intestinal pseudo-obstruction (CIPO), andinertia coli as well.[1] The drug was developed by Ironwood Pharmaceuticals, based in Cambridge, Massachusetts.. Linaclotide was ...

Temperatures on dry land hovered near 50 degrees this weekend, but according the National Weather Service Weather Forecast Office, Lake Michigans water temperature was a chilly 32 degrees. So if you thought the 15th annual Lakeview Polar Bear Club polar plunge was made easier by a relatively balmy day, youd be wrong. There was still plenty of shrinkage going on.. Organizers say Saturdays polar plunge drew over 300 participants and has raised over $24,000 so far for two local families.. All of the donations will go toward the Garcia family, whose son Dominic has Chronic Intestinal Pseudo-Obstruction (CIPO), and the Linblad family, whose son Nicholas is battling a congenital heart disease. Both families are burdened with mounting medical expenses, and the Lakeview Polar Club hopes to raise $32,000 to help ease some of the financial pressures both families are under.. The organization is still short of their hoped for goal and will be updating their website with news of further donations over ...

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Intestinal pseudo-obstruction is a clinical syndrome caused by severe impairment in the ability of the intestines to push food through. It is characterized by the signs and symptoms of intestinal obstruction without any lesion in the intestinal lumen. Clinical features can include abdominal pain, nausea, severe distension, vomiting, dysphagia, diarrhea and constipation, depending upon the part Specialty: Gastroenterology ...

Causes of secondary intestinal pseudo-obstruction include abdominal or pelvic surgery, infections, medications such as opiates and antidepressants that affect muscles and nerves.

Oxidative Phosphorylation, Phosphorylation, Genes, DNA, Mitochondrial DNA, Mutations, Intestinal Pseudo-obstruction, Mitochondrial Disorders, Patients, Acidosis, Arrhythmia, ATP, Birth, Cardiomyopathies, Cardiomyopathy, Counseling, Dependency, Diagnosis, Disease, Genetic Counseling

Poly(ADP-ribose) polymerases (PARP) comprise a family of enzymes which catalyse poly(ADP-ribosyl)ation of DNA-binding proteins. Multiple researches indicate the importance of PARP in promoting cell recruitment and thereby inducing organ injury in various forms of inflammation, such as colitis. We have evaluated the effects of two PARP inhibitors, nicotinamide and 1,5-dihydroxyisoquinoline, in acute colitis induced by trinitrobenzensulfonic acid (TNBS) in rats. Nicotinamide (20-40 mg/kg) and 1,5-dihydroxyisoquinoline (4-8 mg/kg) were administered 48, 24 and 1 h prior to the induction of colitis as well as 24 h later. 48 h after colitis induction the lesions were blindly scored and quantified as ulcer index. Histological study and colonic inflammation were assessed by gross appearance and myeloperoxidase (MPO) activity. Prostaglandin E2 (PGE2) synthesis and, cyclooxygenase-1 and cyclooxygenase-2 expressions by Western blotting and immunohistochemistry were also performed. Inflammation following TNBS

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One of his best-known accomplishments was to include vulgar slang for copulation and female genitalia. But he also frequently bragged of being far less opposed than previous editors to including foreign words. According to Dr. Ogilvies book, he once told Newsweek, It seemed obvious to me that the vocabulary of all English-speaking countries abroad should receive proper attention ...

A wise woman with the name of Christy Beam and her family seem to have the answer. She told us all about it, in riveting details, in her book titled Miracles from Heaven: A Little Girl, Her Journey to Heaven, and Her Amazing Story of Healing.. The book is a memoir of how her daughter Annabel, then 10 years of age, recovered from a rare intestinal disease called pseudo-obstruction motility disorder. For a layman like me, it means the disability to digest food. After many months of medical treatment, and continual pain and suffering on that little body, she was basically sent home to die. While playing in her backyard with her older sister, they climbed up a huge but dead cottonwood tree that measured almost 3 stories high. She fell head-down into the hollow of the trunk. It took rescuers 3 hours before they could hoist her out of that narrow pit and flew her to a nearby hospital. She woke up shortly with no serious injuries: no broken bones, no neurological damage, none whatsoever.. After she was ...

In terms of CIPO, sequencing patients genomes it could mean that we can find the underlying causes of CIPO - it could be that CIPO has more than one causative gene, which would mean we could even find different subtypes of pseudo-obstruction based on the different underlying gene mutation. However, this would have huge implications for CIPO. If we know the underlying gene mutation/mutations, we will find out the underlying basis of CIPO and the underlying mechanism of how it causes the condition. This could then lead to treatments that rectify the problem with the function relating to the gene, or actually treating the gene mutation itself with gene therapy. This could lead to treatments, or even a cure, for the condition.. The first CIPO patient has already been recruited by Professor Knowles. P.O.R.T. hopes to support the recruitment of patients with CIPO onto the 100,000 Genomes Project and to progress the understanding of and development of treatments for CIPO.. You can find out more about ...

A slowing of gastrointestinal motility that is not associated with mechanical obstruction. Most commonly presents following surgery and usually lasts 2 to 4 days. Prolonged postoperative ileus contributes significantly to longer hospitalisation and increased healthcare costs. Treatment includes b...

Auscultation makes it possible to examine the motor function of the intestine. In a healthy child, 5-7 hours after eating, rhythmic noises are heard in the projection zone of the cecum. Enhanced intestinal motility can be observed with mechanical obstruction; with enterocolitis, it can be combined with loud rumbling. The accumulated clinical experience and scientific research suggest that a well-collected history and a thorough clinical examination of the child (which, in addition to visual examination and palpation, must necessarily be accompanied by a rectal digital examination and examination of the perianal region) is usually sufficient to exclude an organic cause of constipation [12 , fifteen].In this situation, there is no need to carry out a complex set of examinations and laboratory tests before starting treatment. Only in the absence of improvement against the background of traditional therapy or in atypical cases with alarming clinical symptoms (the presence of pathological impurities ...

Bowel obstruction occurs when the normal flow of intraluminal contents is interrupted. Obstruction can be functional (due to abnormal intestinal physiology) or due to a mechanical obstruction, which can be acute or chronic. Advanced small bowel obstr

Gastroparesis is a long-standing disorder of the stomach characterized by delayed emptying of the stomach in the absence of mechanical obstruction. Simply put, the stomach takes too long to empty its contents. Gastroparesis may present with a variety of symptoms, which include early satiety, nausea, vomiting, bloating, and upper abdominal discomfort. Related terms:hyperglycemia and gastroparesisprokinetic […]. ...

Yes. Gastroparesis is defined by delayed gastric emptying in the absence of any mechanical obstruction. To put it more simply, food stays in the stomach lo...

In some individuals with primary intestinal pseudo-obstruction, the condition is caused by mutations in the FLNA gene. This gene provides instructions for producing the protein filamin A, which helps build the network of protein filaments (cytoskeleton) that gives structure to cells and allows them to change shape and move. Filamin A attaches (binds) to another protein called actin and helps it form the branching network of filaments that make up the cytoskeleton.. Some individuals with primary intestinal pseudo-obstruction have FLNA gene mutations that result in an abnormally short filamin A protein. Others have duplications or deletions of genetic material in the FLNA gene. Researchers believe that these genetic changes may impair the function of the filamin A protein, causing abnormalities in the cytoskeleton of nerve cells (neurons) in the gastrointestinal tract. These abnormalities interfere with the nerves ability to produce the coordinated waves of muscle contractions (peristalsis) that ...

TY - JOUR. T1 - Can intestinal pseudo-obstruction drive recurrent stroke-like episodes in late-onset MELAS syndrome? A case report and review of the literature. AU - Gagliardi, Delia. AU - Mauri, Eleonora. AU - Magri, Francesca. AU - Velardo, Daniele. AU - Meneri, Megi. AU - Abati, Elena. AU - Brusa, Roberta. AU - Faravelli, Irene. AU - Piga, Daniela. AU - Ronchi, Dario. AU - Triulzi, Fabio. AU - Peverelli, Lorenzo. AU - Sciacco, Monica. AU - Bresolin, Nereo. AU - Comi, Giacomo Pietro. AU - Corti, Stefania. AU - Govoni, Alessandra. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a maternally inherited mitochondrial disorder that is most commonly caused by the m. 3243A,G mutation in the MT-TL1 mitochondrial DNA gene, resulting in impairment of mitochondrial energy metabolism. Although childhood is the typical age of onset, a small fraction (1-6%) of individuals manifest the disease after 40 years of age and usually ...

A 2-year-old boy presented to our childrens hospital with a 5-day history of fever and 2 days prior to admission he progressively developed a maculopapular rash in thorax and genitals, had erythema and edema in palms and soles, bilateral conjunctival injection, swollen red lips, and a strawberry tongue. On the day of admission he developed a distended and painful abdomen, diarrhea, and vomiting. On examination he was febrile (39.8 C), heart rate was 180 beats/minute, met 5 major clinical diagnostic criteria for KD, and also presented a diffusely distended tender but soft abdomen, with no rebound sign. He received 1 dose of IVIG [2 g/Kg] and was started on acetylsalicylic acid (ASA) [100 mg/Kg/day]. Because of persistent abdominal distention and vomiting, a plain abdominal radiograph was performed which showed air fluid levels with diffuse small bowel loops distention, all of these consistent with an intestinal pseudoobstruction. An abdominal ultrasound revealed gallbladder hydrops, fluid-filled ...

ABSTRACT. African degenerative leiomyopathy (ADL) is a rare incurable disorder seen in African children, predominantly in southern and south-eastern Africa. ADL presents as chronic intestinal pseudo-obstruction. Management is traditionally conservative, with surgery restricted to the management of complications. We have placed Malone antegrade continence enema (MACE) stomas in the grossly dilated colon to vent accumulated gas and administer antegrade bowel enemas. This is done mainly for relief of gaseous distension and constipation in an attempt to provide symptomatic relief and improve quality of life. In this article, we present our preliminary results of laparoscopically assisted technique to insert a Mic-Key gastrostomy device as a button colostomy in 8 patients over the past 6½ years.. ...

Chronic Intestinal Pseudo-obstruction Pediatric and Adolescent Gastrointestinal Motility & Pain Program Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, Louisiana

Before more settlements could be established, The Quebec - Ontario boundary north of Lake Timiskaming had to be accurately surveyed. Earlier surveys by Quebec and Ontario resulted in a boundary dispute, so the Canadian government sent a survey team to resolve the issue in 1890. William Ogilvie, who had recently distinguished himself by accurately surveying the Canada - Alaska boundary, led the expedition. A benchmark near Mattawa was used to establish an accurate benchmark north of Lake Timiskaming, using astronomical methods. From the head of Lake Timiskaming, they proceeded north to James Bay, fixing accurate positions of the provincial boundary at regular intervals using geodesy data derived from star transits. Ogilvies journal describe conditions in this area and the early settlers he met. His report on this expedition describes the details of this expedition.[9]. William Murray (1840-1906) and Irvin Heard (1871-1956) were the first European settlers in the New Liskeard area, arriving in ...

Understanding how dietary components alter the healthy baseline colonic microenvironment is important in determining their roles in influencing gut health and gut-associated diseases. Dietary flaxseed (FS) has demonstrated anti-colon cancer effects in numerous rodent models, however, exacerbated acute colonic mucosal injury and inflammation in a colitis model. This study investigates whether FS alters critical aspects of gut health in healthy unchallenged mice, which may help explain some of the divergent effects observed following different gut-associated disease challenges. Four-week-old C57Bl/6 male mice were fed an AIN-93G basal diet (BD) or an isocaloric BD+10% ground FS diet for 3 weeks. FS enhanced colon goblet cell density, mucus production, MUC2 mRNA expression, and cecal short chain fatty acid levels, indicative of beneficial intestinal barrier integrity responses. Additionally, FS enhanced colonic regenerating islet-derived protein 3 gamma (RegIIIγ) and reduced MUC1 and resistin-like ...

The diagnosis of this condition is not always straightforward due to sometimes unspecific and subtle initial symptoms and having a high level of suspicion in patients with a history of cholelithiasis is key. Beside the clinical symptoms of obstructive gastric ileus, the diagnosis nowadays is mainly made by endoscopy, abdominal ultrasound, and/or x-ray and/or CT-scan. While upper endoscopy has a very high success rate in diagnosing the mechanical obstruction, it fails to correctly identify an impacted gallstone as the cause in almost one-third of patients (as the stone can be deeply embedded within the mucosa and blood and clots may obstruct the view). A diagnostic aid is the presence of Riglers triad on plain abdominal x-ray films, consisting of a dilated stomach, pneumobilia (air in the biliary tree) and a radio-opaque shadow in the region of the duodenum representing the migrated gallstone. If further migration of the gallstone can be detected on follow up x-ray films, then this completes ...

Product Constituents. URINALYSIS, URIC ACID, BUN, CREATININE, BUN/CREATININE RATIO, TOTAL PROTEIN, ALBUMIN, GLOBULIN, ELECTROLYTES. Category. KIDNEY RELATED DISORDERS. Prerequisite. No special preparation required. Report Availability. Same Day. Info. Creatinine and electrolyte levels help to detect kidney disorders. increased BUN level indicates kidney disease, heart failure, gout, and pregnancy diseases. urea is the principle waste product of protein catabolism. BUN is most commonly measured in the diagnosis and treatment of certain renal and metabolic diseases. increased BUN concentration may result from increased production of urea due to (1) diet or excessive destruction of cellular proteins as occurs in massive infection and fevers, (2) reduced renal perfusion resulting from dehydration or heart failure, (3) nearly all types of kidney disease, and (4) mechanical obstruction to urine excretion such as is caused by stones, tumors, infection, or stricture. decreased urea levels are less ...

The patient with congenital heart disease who presents for noncardiac surgery requires careful evaluation and planning to avoid adverse perioperative events. This chapter presents a physiological approach to the management of anesthesia for the most common congenital heart lesions. The various congenital heart defects are categorized into lesions resulting in: (1) left-to-right shunting; (2) right-to-left shunting; (3) complete mixing of pulmonary and systemic circulation; (4) complete separation of the pulmonary and systemic circulations; (5) increased myocardial work; and (6) mechanical obstruction of the airway.

In patients with MS, several studies have demonstrated that LA enlargement is a marker of increased thromboembolic risk (4,6,7,9,11,25,26). However, the great majority of studies considered LA size or volume as an indicator of risk. This study aimed to look specifically at LA shape and not just LAVs and LA function in predicting stroke. As LA dilation may not occur in a uniform fashion, LA shape might be a better measure of the pattern of LA remodeling and a better predictor of embolic risk than absolute LAV.. The results of this study show that the atrial shape adds incremental value in predicting embolic events. Additionally, in agreement with a recently published study (27), we found that LA reservoir function was also associated with an increased risk for ECE. Although the LA has 3 major roles that affect LV filling, its reservoir function represents the most important component of the LA function in MS. LA contractile force cannot overcome the mechanical obstruction across the valve and ...

Now, some details about venous or passive hyperaemia. Passive hyperaemia or venous congestion is increased blood supply to an organ or tissue due to reduced blood outflow through the veins. In venous congestion, blood velocity always decreases, decelerates. The etiology of venous congestion is related either to mechanical obstruction of blood flow in the veins. It can be thrombi or emboli, or it is resulted from external compression of the veins by ligation, by tumor, sometimes by pregnant uterus, if we speak about veins or abdominal cavity in pregnant women. It can be also some adhesions prevailing from normal venous outflow. And, here, you can see an illustration of the situation of total venous congestion in many vascular areas. It can occur in heart failure because of increase of venous pressure due to disorder of pumping functions, and it may occur simultaneously in many vascular beds, for example, with right heart failure or cor pulmonale. It may be observed in the greater circulation ...

The complex model of the lower part of the urinary consists of the detrusor smooth muscle cell model and the detailed 1D model of the urethra flow. In future this model will allow to simulate the influence of different drugs and mechanical obstructions in the bladder neck and urethra. A general muscle model involving the calcium dynamics in the smooth muscle cell and the growth and remodelling theory will be shortly introduced. The main part is devoted to the development of a simple bladder model and the detrusor contraction during voiding together with the detailed model of the urethra flow ...

Is the invagination or telescoping of a portion of the intestine into a adjacent, more distal section of the intestine causing mechanical obstruction. The cause may be idiopathic (unknown but.... ...

Background. the genetic diversity of human immunodeficiency virus type 1 (HIV-1) raises the question of whether vaccines that include a component to elicit antiviral T cell immunity based on a single viral genetic clade could provide cellular immune protection against divergent HIV-1 clades. Therefore, we quantified the cross-clade reactivity, among unvaccinated individuals, of anti-HIV-1 T cell responses to the infecting HIV-1 clade relative to other major circulating clades.Methods. Cellular immune responses to HIV-1 clades A, B, and C were compared by standardized interferon-gamma enzyme-linked immunospot assays among 250 unvaccinated individuals, infected with diverse HIV-1 clades, from Brazil, Malawi, South Africa, Thailand, and the United States. Cross-clade reactivity was evaluated by use of the ratio of responses to heterologous versus homologous ( infecting) clades of HIV-1.Results. Cellular immune responses were predominantly focused on viral Gag and Nef proteins. Cross-clade ...