In patients with locally advanced colon cancer (high risk stage II and stage III), curative surgery followed by adjuvant FOLFOX-4 chemotherapy has become the standard of care. However, for 30-40% of these patients, the current curative treatment strategy of surgical excision followed by adjuvant chemotherapy fails either to clear locoregional spread or to eradicate distant micrometastases, leading to disease recurrence. Preoperative chemotherapy is an attractive concept for locally advanced colon cancer and has the potential to impact upon both of these causes of failure. Optimum systemic therapy at the earliest possible opportunity may be more effective at eradicating distant metastases than the same treatment given after the delay and immunological stress of surgery. Added to this, shrinking the primary tumor before surgery may reduce the risk of incomplete surgical excision, and the risk of tumor cell shedding during surgery.. ECKINOXE is a multicenter randomized phase II trial designed to ...
In patients with locally advanced colon cancer (high risk stage II and stage III), curative surgery followed by adjuvant FOLFOX-4 chemotherapy has become the standard of care. However, for 30-40% of these patients, the current curative treatment strategy of surgical excision followed by adjuvant chemotherapy fails either to clear locoregional spread or to eradicate distant micrometastases, leading to disease recurrence. Preoperative chemotherapy is an attractive concept for locally advanced colon cancer and has the potential to impact upon both of these causes of failure. Optimum systemic therapy at the earliest possible opportunity may be more effective at eradicating distant metastases than the same treatment given after the delay and immunological stress of surgery. Added to this, shrinking the primary tumor before surgery may reduce the risk of incomplete surgical excision, and the risk of tumor cell shedding during surgery.. ECKINOXE is a multicenter randomized phase II trial designed to ...
Mucin production by human colonic carcinoma cells correlates with their metastatic potential in animal models of colon cancer metastasis.: Patients with mucinou
BioAssay record AID 86084 submitted by ChEMBL: In vitro cytotoxicity against human colon adenocarcinoma cell line HT-29 at 5.9*10e-5M.
Berberine reduces cAMP-induced chloride secretion in T84 human colonic carcinoma cells through inhibition of basolateral KCNQ1 channels
The American Cancer Society and the Cigna Foundation have awarded $232,000 to MedStar Washington Hospital Center to address advanced colon cancer.
Genes May Determine Aspirins Effect on Advanced Colon Cancer, Harvard School of Public Health Study - read this article along with other careers information, tips and advice on BioSpace
This page provides useful content and local businesses that can help with your search for Colon Cancer Treatment. You will find helpful, informative articles about Colon Cancer Treatment, including Colon Cancer. You will also find local businesses that provide the products or services that you are looking for. Please scroll down to find the local resources in Lakeville, MN that will answer all of your questions about Colon Cancer Treatment.
This page provides useful content and local businesses that can help with your search for Colon Cancer Treatment. You will find helpful, informative articles about Colon Cancer Treatment, including Colon Cancer. You will also find local businesses that provide the products or services that you are looking for. Please scroll down to find the local resources in Carson City, NV that will answer all of your questions about Colon Cancer Treatment.
Colon Cancer Treatment cost in India starts from USD 7000. Find affordable packages, best specialists, hospitals and patient experiences for Colon Cancer Treatment in India through Vaidam.
We believe this is the first case report of anunusual presentation of hypercalcemia due to sarcoidosis mimicking metastatic colon carcinoma. A 68 year old lady with a background history of pancolectomy and neoadjuvant chemotherapy for Duke C1 rectal carcinoma under surveillance, ulcerative colitis, type 2 diabetes mellitus presented to the clinic with hypercalcemia with low parathyroid hormone (PTH) and symptoms of tiredness. Her blood test showed Adj Ca of 2.8 mmol/l, PTH , 2.5 pmol/l, Vitamin D 18 mol/l, ALP 177 U/l. She was commenced on 800 IU of vitamin D, ordered for bone scan, 24 h urine calcium excretion ratio, myeloma screen. Her surveillance CT scan couple of months earlier was reported stable features. She had an acute medical admission with unsteadiness of gait, tiredness and nausea. The adjusted calcium level was reported as 3.6 mmol/l with suppressed PTH. She was resuscitated with intravenous fluids and bisphosphate infusion. A CT scan of abdomen, chest and pelvis was organised that ...
A patient with a metastatic colon carcinoma was treated by immunoadsorption (IA) therapy using heat-killed, formalin-stabilized protein A-containing Staphylococcus aureus Cowan I as the immunoadsorbent. The patient experienced both subjective and objective positive clinical response without undue morbidity. The patients response correlated well with laboratory findings of decreased concentrations of carcinoembryonic antigen (CEA), immunoglobulin G (IgG), immune complexes (IC) and histopathologic data. The patient underwent surgery following 15 IA treatments; she lived for eighteen months, post-treatment.
Colon cancer is one of the most frequent solid tumor and simultaneous diagnosis of primary colon cancer and liver metastases occurs in about one fourth of cases. The current knowledge on epigenetic signatures, especially those related to hydroxymethylation in primary cancer tissue, synchronous metastasis and blood circulating cells is lacking. This study aimed to investigate both methylcytosine (mCyt) and hydroxymethylcytosine (hmCyt) status in the DNA of individual patients from colon cancer tissue, synchronous liver metastases, and in cancer-free colon and liver tissues and leukocytes. Patients undergoing curative surgery (n=16) were enrolled and their laboratory and clinical history data collected. The contents of mCyt and hmCyt were determined by a liquid chromatography/mass spectrometry (LC/MS/MS) method in DNA extracted from primary colon cancer, synchronous hepatic metastatic tissues and homologous cancer-free tissues, i.e., colon and liver tissues as well as leukocytes. The mCyt and hmCyt
Researchers have identified a biomarker that predicts which stage II colon cancer patients may benefit from adjuvant chemotherapy.
TY - JOUR. T1 - Single-dose versus fractionated radioimmunotherapy of human colon carcinoma xenografts using 131I-labeled multivalent CC49 single-chain Fvs1. AU - Goel, A.. AU - Augustine, S.. AU - Baranowska-Kortylewicz, Janina. AU - Colcher, D.. AU - Booth, B. J M. AU - Pavlinkova, G.. AU - Tempero, M.. AU - Batra, Surinder Kumar. PY - 2001/2/12. Y1 - 2001/2/12. N2 - The prospects of radiolabeled antibodies in cancer detection and therapy remain promising. However, efforts to achieve cures, especially of solid tumors, with the systemic administration of radiolabeled monoclonal antibodies (MAbs) have met with limited success. Using genetic engineering techniques, MAbs have been tailored to improve the therapeutic index (tumor:normal tissue ratio) in clinical radioimmunotherapy. In the present study, we investigated the potential of tetravalent {[sc(Fv)2]2} and divalent [sc(FV)2] single chain Fvs of MAb CC49 for therapy in athymic mice bearing s.c. LS-174T human colon carcinoma xenografts. Mice ...
TY - JOUR. T1 - Completion of therapy by medicare patients with stage III colon cancer. AU - Dobie, Sharon A.. AU - Baldwin, Laura Mae. AU - Dominitz, Jason A.. AU - Matthews, Barbara. AU - Billingsley, Kevin. AU - Barlow, William. PY - 2006/5/3. Y1 - 2006/5/3. N2 - Background: Certain factors, such as race or age, are known to be associated with variation in initiation of adjuvant chemotherapy for stage III colon cancer, but little is known about what factors are associated with completion of adjuvant therapy. To determine whether predictors of initiation also predict completion, we analyzed Surveillance, Epidemiology, and End Results (SEER) program data linked to Medicare claims. We investigated mortality as a means to testing the validity of the completion measure that we created. Methods: We studied 3193 stage III colon cancer patients whose diagnosis was recorded in 1992-1996 SEER program data linked to 1991-1998 Medicare claims and who initiated adjuvant chemotherapy after colon cancer ...
Currently, data regarding the prognosis of right-sided versus left-sided colon cancer are conflicting, however, most studies revealed a poorer survival in right-sided primary tumor location [14-18, 29].. To our knowledge this is the first population-based, propensity score adjusted analysis investigating the prognostic impact of tumor location in non-metastatic colon cancer patients. Being aware of the conflicting data and also of the challenges to handle relevant bias due to substantial imbalances regarding baseline characteristics between right- and left-sided colon cancer patients, we have intentionally selected the propensity score matching as a further statistical method in addition to common multivariate analysis to minimize confounding. In the present analysis, the cohort was partitioned into subgroups containing one or more patients with right-sided colon cancer who were matched to one or more patients with left-sided colon cancer with similar values on the observed covariates in the ...
TY - JOUR. T1 - Identification of Endogenous Inhibitory Growth Factors from a Human Colon Carcinoma Cell Line. AU - Levine, Alan E.. AU - McRae, L. J.. AU - Hamilton, David A.. AU - Brattain, Diane E.. AU - Yeoman, Lynn C.. AU - Brattain, Michael G.. PY - 1985/5/1. Y1 - 1985/5/1. N2 - A line of human colon carcinoma cells, designated MOSER, was established which synthesized tumor-inhibitory factor (TIF) and transforming growth factor (TGF) activity. Both activities were found in serum-free conditioned medium and in cell extracts. The activities coelute on Bio-Gel P-10 in acetic acid, but can be completely separated by reverse-phase high-pressure liquid chromatography. The TIF and TGF activities were acid and heat stable and were sensitive to trypsin and dithiothreitol. MOSER cell TIF prevented the anchorage-independent growth of the more differentiated colon carcinoma cell lines tested but did not affect the less differentiated lines. Using anchorage-dependent growth conditions, the effect of ...
2018 American Association for Cancer Research. Unresectable hepatic metastases of colon cancer respond poorly to existing therapies and are a major cause of colon cancer lethality. In this study, we evaluated the therapeutic viability of targeting the mediator kinase CDK8, an early clinical stage drug target, as a means to suppress metastasis of colon cancer. CDK8 was amplified or overexpressed in many colon cancers and CDK8 expression correlated with shorter patient survival. Knockdown or inhibition of CDK8 had little effect on colon cancer cell growth but suppressed metastatic growth of mouse and human colon cancer cells in the liver. This effect was due in part to inhibition of already established hepatic metastases, indicating therapeutic potential of CDK8 inhibitors in the metastatic setting. In contrast, knockdown or inhibition of CDK8 had no significant effect on the growth of tumors implanted subcutaneously, intrasplenically, or orthotopically in the cecum. CDK8 mediated colon cancer ...
BACKGROUND: Circular RNAs (circRNAs) are considered to be highly stable due to the closed structure, which are predominately correlated with the development and progression of a wide variety of cancers. Colon cancer is one of the most common malignancies worldwide. A recent study demonstrated the upregulated expression of circPIP5K1A in non-small cell lung cancer. However, few studies have investigated the relationship between circ_0014130 level and colon cancer. Therefore, elucidating the underlying mechanisms of circPIP5K1As role may help with the identification of novel diagnostic and therapeutic targets for colon cancer. AIM: To investigate the status of circPIP5K1A in colon cancers and its effects on the modulation of cancer development. METHODS: The expression level of circPIP5K1A in tissue and serum samples from colon cancer patients, as well as human colonic cancer cell lines was detected by real-time quantitative reverse transcription-polymerase chain reaction. Following the ...
4334 Vascular endothelial growth factor (VEGF) has been shown to be associated with tumor angiogenesis and poor prognosis in human colon cancer. VEGF receptor-1 (VEGFR-1/Flt-1) is a high-affinity receptor for VEGF and is typically viewed as being endothelial cell specific. Here we report on the expression and function of VEGFR-1 on colon cancer cell lines. VEGFR-1 was expressed in 7/7 colon cancer cell lines as determined by Western blot analysis. Treatment of the human colon cancer cell line SW480 with VEGF-A (ligand for both VEGFR-1 and VEGFR-2) or VEGF-B (a ligand specific for VEGFR-1) led to activation of Erk 1/2. A blocking antibody to VEGFR-1 (18F1) completely inhibited the ability of VEGF-A and -B to activate Erk 1/2 in SW480 cells. VEGF-A and B did not increase colon cancer cell proliferation as determined by the MTT assay. However, VEGF-A and VEGF-B led to a significant induction of cancer cell motility and invasion through Matrigel. VEGF-A and -B stimulation of colon tumor cells also ...
Colon cancer treatments are varied and you can choose from a series of traditional and alternative methods of dealing with this condition. Surgery is often the number one choice - the surgeon removes the tumors on the colon, even if the cancer cells are spread beyond the colon itself. This ensures less problems in the future of the patients life, reducing chances of bowel problems or internal bleeding. Colon cancer surgery is usually categorized in four main areas: rectum resection, radio frequency ablation, colostomy and colon resection. The surgeon will determine which method is best suited for each individual patient ...
ORLANDO-Compared with the standard first-line chemotherapy treatment for advanced colorectal cancer, patients treated with the FOLFOX4 regimen containing the investigational agent oxaliplatin lived longer and had fewer side effects. 1
Evidence-Based Complementary and Alternative Medicine (eCAM) is an international peer-reviewed, Open Access journal that seeks to understand the sources and to encourage rigorous research in this new, yet ancient world of complementary and alternative medicine.
Colon cancer is the second leading cause of cancer death in men and women. New Hope Unlimiteds alternative colon cancer treatment consists of a non-invasive, less toxic and more effective treatment strategy that improves the symptoms and reverse the disease. Know your options and call us at 480-845-0813.
Background Cyclooxygenase-2 (COX-2) is a key factor in the development of colorectal cancer, and non-steroidal anti-inflammatory drugs (NSAIDs) have anti-colorectal cancer activity. However, the potential molecular mechanism of the COX-2 selective inhibitor effect on proliferation and apoptosis of colon cancer cells is unclear. In this study, we have demonstrated for the first time that the Delta1/Notch1 signal transduction pathway mediates the COX-2 selective inhibitor effect on colorectal cancer cells, and we reveal the mechanism of the Notch1 pathway in terms of regulating the proliferation and apoptosis of colorectal cancer cells. Methods and Result Colon cancer cell lines HT-29 and SW480 were treated with NS-398 (a COX-2 selective inhibitor) and DAPT (a gamma-secretase inhibitor). The colormetric MTT cell proliferation assay and flow cytometry were used to measure cell proliferation and apoptosis. Reverse transcriptase (RT)-PCR and ELISA analyses were used to detect the levels of COX-2 mRNA ...
TY - JOUR. T1 - RACK1 downregulates levels of the pro-apoptotic protein Fem1b in apoptosis-resistant colon cancer cells. AU - Subauste, M. Cecilia. AU - Ventura-Holman, T.. AU - Du, L.. AU - Subauste, Jose S.. AU - Chan, Shing Leng. AU - Yu, Victor C.. AU - Maher, Joseph F.. PY - 2009/12/1. Y1 - 2009/12/1. N2 - Evasion of apoptosis plays an important role in colon cancer progression. Following loss of the Apc tumor suppressor gene in mice, the gene encoding Fem1b is upregulated early in neoplastic intestinal epithelium. Fem1b is a pro-apoptotic protein that interacts with Fas, TNFR1 and apaf-1, and increased expression of Fem1b induces apoptosis of cancer cells. Fem1b is a homolog of FeM-1, a protein in Caenorhabditis elegans that is negatively regulated by ubiquitination and proteasomal degradation. To study Fem1b regulation in colon cancer progression, we used apoptotis-sensitive SW480 cells, derived from a primary colon cancer, and their isogenic, apoptosis-resistant counterparts sW620 cells, ...
Learn about Colon Cancer Treatment (Patient). Information from PDQ, the National Cancer Institutes comprehensive cancer information database.
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Cancer Monthly. Colon Cancer treatments. Chemotherapy. Monash University, Melbourne, Australia. Compare therapy differences, longest survival rates, toxicity, side effects, hospitals.
Cancer Monthly. Colon Cancer treatments. Chemotherapy. Universitat Aut noma de Barcelona, Barcelona, Spain. Compare therapy differences, longest survival rates, toxicity, side effects, hospitals.
It is pertinent however to determine wholesome cooking strategies in addition to consuming habits in methods to not intervene with the nutritious worth of meals Mother Nature intended. Have you ever ever gone through a grueling weight reduction program for a very long time, solely to seek out out later that youve hit a wall when it comes to outcomes. You wont end up tempted almost as much if your forbidden foods arent simply accessible. Correctly, chances are youll need to do additional than merely discovering a meals plan reply program. He did it greater than 50 years earlier. One factor to remember when deciding how one can go about shedding pounds is that there is no such thing as a single greatest way to lose weight. This can be a weight loss program thats loaded with numerous greens and fruits, chemopreventive effects of dietary canola oil on colon cancer development with the lean meats and likewise other protein sources. Due to this actuality, it is best to avoid excessive consumption ...
Among patients with Stage II or Stage III colon cancer, the Oncotype DX colon cancer test provides information about risk of cancer recurrence and may help guide treatment decisions. These results were presented at the 2012 Annual Meeting of the American Society of Clinical Oncology.. Gene expression profiling explores the patterns of genes that are active in tumor cells. Studies suggest that gene expression may provide important information about prognosis or likely response to treatment in several types of cancer. For example, among women with early-stage, estrogen receptor-positive breast cancer, the Oncotype DX breast cancer test has been shown to predict the likelihood of cancer recurrence and the likelihood of benefit from chemotherapy. As a result, the test has been added to medical guidelines for early-stage breast cancer.. A similar test became available for colon cancer patients in 2010. The test was originally developed for use in patients with Stage II colon cancer, but has now also ...
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Before talking about colon cancer prevention, lets talk a little about what colon cancer is, exactly. Both the colon and rectum are part of the digestive system. The first part of the digestive system, which is the esophagus and stomach, breaks down food to be processed into energy. Next, the broken down food travels to the small intestine/bowel, which is a narrow, 20-foot section that continues breaking down food and absorbing most of the nutrients. The small intestine then sends the remaining material to the five-foot-long colon (which is also referred to as "the large intestine"), where it absorbs salt and water and stores waste. The first part of the colon is the ascending colon, which is attached to the small intestine and the appendix on the right side of the abdomen. The transverse colon runs from the right to the left side of the upper abdomen. The descending colon travels downward on the left side and the sigmoid colon is an S-shaped portion that passes food matter down to the rectum, ...
We previously reported that CIN85, an 85 KDa protein known to be involved in tumor cell migration and metastasis through its interaction with Cbl, associates with MUC1 in tumor cells. MUC1/CIN85 complex also regulates migration and invasion of tumor cells in vitro. Here, we examined specifically human colon carcinoma tissue microarrays (TMA) by immunohistochemistry for the expression of MUC1 and CIN85 and their potential role in cancer progression and metastasis. We detected a significant increase in expression of both MUC1 and CIN85 associated with advanced tumor stage and lymph node metastasis. We further investigated if Cbl could also be present in the MUC1/CIN85 complex. Co-immunoprecipitation assay showed that Cbl co-localized both with CIN85 and with MUC1 in a human colon cancer cell line. To begin to investigate the in vivo relevance of MUC1 overexpression and association with CIN85 and Cbl in cancer development and progression, we used human MUC1 transgenic mice that express MUC1 on the colonic
denotes superscript. Background: This study was conducted to develop a non-invasive orthotopic model for metastasis of colon and rectal cancer using a trans-anal approach that is non-operative, reproducible, and easy to perform. Currently, the most accurate orthotopic representation of metastatic human colon cancer is a cecal injection. The trans-anal model allows for further examination of systemic immune responses, tumor take, and onset of metastasis without prior surgical intervention.. Methods: Sixty (60) Balb/c mice were anesthetized and received gentle anal dilation using blunt tipped forceps at the anal opening. Using a 29 gauge syringe, murine colon cancer parental CT26 (CT26) or luciferase labeled CT26 (CT26-luc) cells were injected submucosally into the distal, posterior rectum (CT26 N=30 and CT26-luc N=30) at various concentrations: 2.5×10(^4), 1×10(^5), or 1×10(^6) in a volume of 50µL. All mice were injected using 100 x magnification. Tumor growth and metastatic development was ...
Background: Mucin, a family of high molecular weight glycoprotein has been implicated in a variety of cancers. MUC13 is a newly identified transmembrane mucin which has shown deregulated expression in gastric and ovarian cancers. However, limited information is available about the role of MUC13 in colon cancer progression. The present study investigated the expression profile, clinical relevance and functional significance of MUC13 expression in colon cancer progression.. Materials and Methods: The MUC13 expression profile was determined by immunohistochemical (IHC) analysis using a novel MUC13 monoclonal antibody (PPZ0020) on a panel of colon cancer tissue microarrays containing non-malignant, colon cancer and liver metastasis tissue samples. Colon cancer cell lines which showed faint (SW480) and high (SW620) MUC13 expression were selected for over-expression and knockdown experiments, respectively, to determine the functional role of MUC13 in colon cancer progression. Functional studies, such ...
Todays guest is Wade Hayes, country singer and advanced colon cancer survivor. He is here with us to help support awareness in colon cancer during Colon Cancer Awareness Month in March—a disease impacting nearly 93,000 people this year. Wade was at the height of his country music career with Billboard hits and a promising road ahead when he was diagnosed with stage IV colon cancer. Like so many people facing a cancer diagnosis, he had to put his life on hold. After successful treatment, the singer is determined to reignite his career. Wade is in NYC launching his brand new album and song ?Go Live Your Life?—an emotional song that he wrote after his oncologist told him he was cancer free. For every download of ?Go Live Your Life? purchased on iTunes, a donation of a $1 will be made to the Colon Cancer Alliance Blue Note Fund, a non-profit that supports colon cancer patients who are currently in treatment. Please go visit the site at www.goliveyourlife.com.
TY - JOUR. T1 - Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells. AU - Pollock, Claire B.. AU - Shirasawa, Senji. AU - Sasazuki, Takehiko. AU - Kolch, Walter. AU - Dhillon, Amardeep S.. PY - 2005/2/15. Y1 - 2005/2/15. N2 - RAS oncegenes are thought to play a role at multiple stages of tumorigenesis. The role and mechanisms by which RAS oncogenes maintain the transformed state of human cancer cells are poorly understood. Here, we have studied the role of oncogenic K-RAS in maintaining cytoskeletal disruption, cell adhesion and motility in metastatic colon carcinoma cells. Targeted deletion of K-RASG13D from HCT116 colon carcinoma cells restored their ability to assemble stress fibers and focal adhesions/complexes, accompanied by increased cell-matrix adhesion and reduced motility. We further show that oncogenic K-Ras induces high Rho activity, but uncouples Rho from stress fiber formation. This uncoupling required the ...
Obesity is a global phenomenon and is associated with various types of cancer, including colon cancer. There is a growing interest for safe and effective bioactive compounds that suppress the risk for obesity-promoted colon cancer. Resveratrol (trans
As a disease with extremely complex molecular mechanisms, many deregulated miRNAs have been identified in colon cancer. Few studies have been performed by using Ingenuity Pathways Analysis (IPA) to predict miRNAs specifically expressed in colon cancer. A characteristic microRNA-target network of colon cancer was explored using IPA. Then the clinical significance of miR-19b-3p was evaluated in 211 colon cancer patients. The roles of miR-19b-3p and its candidate target gene, SMAD4, in colon cancer progression were examined both in vitro and in vivo. Bioinformatics analysis showed that 15 microRNAs screened by IPA were significantly correlated with malignant biological behaviors of colon cancer. miR-19b-3p was the most significantly upregulated candidate based on the validation experiment using 211 colon cancer samples. High expression of miR-19b-3p was significantly associated with high N stage (P | 0.001), high AJCC stage (P | 0.001), poor histologic grade (P = 0.032), frequent venous and lymphatic
As a disease with extremely complex molecular mechanisms, many deregulated miRNAs have been identified in colon cancer. Few studies have been performed by using Ingenuity Pathways Analysis (IPA) to predict miRNAs specifically expressed in colon cancer. A characteristic microRNA-target network of colon cancer was explored using IPA. Then the clinical significance of miR-19b-3p was evaluated in 211 colon cancer patients. The roles of miR-19b-3p and its candidate target gene, SMAD4, in colon cancer progression were examined both in vitro and in vivo. Bioinformatics analysis showed that 15 microRNAs screened by IPA were significantly correlated with malignant biological behaviors of colon cancer. miR-19b-3p was the most significantly upregulated candidate based on the validation experiment using 211 colon cancer samples. High expression of miR-19b-3p was significantly associated with high N stage (P | 0.001), high AJCC stage (P | 0.001), poor histologic grade (P = 0.032), frequent venous and lymphatic
Colon cancer remains one of the most common malignancies. In the past decades, there have been substantial developments in diagnostic and clinical treatment regimens for colon cancer. However, its prognosis remains poorer than expected. Therefore, there is still a need for the development of new and effective drugs or strategies for colon cancer treatment. In the present study, the effective anticancer activity of Evo, which may be mediated by BMP9 via the upregulation of HIF-1α to partly increase the activity of p53, was demonstrated in human colon cancer.. It has been reported that Evo exhibits great anti-cancer activities in many types of cancer, such as tongue, breast, colon, prostate and lung cancer (9-12,26,27). As far as colon cancer is concerned, the anticancer activity of Evo may be mediated by inactivating the NF-κB (9) or TGF-β1 (11), or activating the p53/p21/Rb pathway (12). Our previous study indicated that the anti-cancer activity of Evo was associated with the downregulation ...
TY - JOUR. T1 - Folic acid inhibits COLO-205 colon cancer cell proliferation through activating the FRα/c-SRC/ERK1/2/NFκB/TP53 pathway. T2 - In vitro and in vivo studies. AU - Kuo, Chun Ting. AU - Chang, Chieh. AU - Lee, Wen Sen. PY - 2015/6/9. Y1 - 2015/6/9. N2 - To investigate the molecular mechanism underlying folic acid (FA)-induced anti-colon caner activity, we showed that FA caused G0/G1 arrest in COLO-205. FA activated the proto-oncogene tyrosine-protein kinase Src (c-SRC)-mediated signaling pathway to enhance nuclear factor of kappa light polypeptide gene enhancer in B-cells (NFκB) nuclear translocation and binding onto the tumor protein p53 (TP53) gene promoter, and up-regulated expressions of TP53, cyclin-dependent kinase inhibitor 1A (CDKN1A) and cyclin-dependent kinase inhibitor 1B (CDKN1B). Knock-down of TP53 abolished FA-induced increases in the levels of CDKN1A and CDKN1B protein and G0/G1 arrest in COLO-205. Knock-down of folate receptor alpha (FRα) abolished FA-induced ...
TY - JOUR. T1 - Serological immunoreactivity against colon cancer proteome varies upon disease progression. AU - De Monte, Lucia. AU - Sanvito, Francesca. AU - Olivieri, Stefano. AU - Viganò, Fiammetta. AU - Doglioni, Claudio. AU - Frasson, Matteo. AU - Braga, Marco. AU - Bachi, Angela. AU - Dellabona, Paolo. AU - Protti, Maria Pia. AU - Alessio, Massimo. PY - 2008/2. Y1 - 2008/2. N2 - Sera from colon carcinoma patients were used to identify tumor-associated antigens (TAAs) by screening tumor proteome resolved by 2D electrophoresis. A panel of six TAAs eliciting a serological immune response in colorectal cancer was identified, showing a modification in antigen recognition by B cells in patients as a function of colon cancer progression. The expression of these proteins was either confined or increased in tumor as compared to normal mucosa.. AB - Sera from colon carcinoma patients were used to identify tumor-associated antigens (TAAs) by screening tumor proteome resolved by 2D electrophoresis. ...
40 patients were randomised to receive either propofol target controlled infusion with a thoracic epidural at the level of T9-12 or to sevoflurane with intraoperative sufentanyl and postoperative patient controlled analgesia. Venous blood samples were taken preoperatively and 24 hours postoperatively. Both groups were similar in patient demographics and tumour stage. The ability of colon cancer cells to proliferate in the propofol-epidural patients serum was significantly reduced compared to the sevoflurane-opioid patients serum. The number of invasive colon cancer cells and cell viability ratio was significantly reduced in the propofol-epidural exposed patients serum compared to the sevoflurane opioid group serum. Apoptosis of colon cancer cells was significantly reduced in sevoflurane-opioid exposed patients serum. The neutrophil/leukocyte ratio, a marker of inflammation, was lower in patients serum who received propofol-epidural analgesia. ...
Buy our Caco 2 (human colonic carcinoma cell line) whole cell lysate. ab3950 has been validated in western blot. Abcam now offers a 12-month guarantee.
TY - JOUR. T1 - Apoptotic Effects of Drug Targeting Conjugates Containing Different GnRH Analogs on Colon Carcinoma Cells. AU - Lajkó, Eszter. AU - Hegedüs, Rózsa. AU - Mező, G.. AU - Kőhidai, L.. PY - 2019/9/8. Y1 - 2019/9/8. N2 - The wide range of cellular target reactions (e.g., antitumor) of gonadotropin-releasing hormone (GnRH) variants provides the possibility to develop multifunctional GnRH conjugates. The aim of our work was to compare the cytotoxic/apoptotic activity of different GnRH-based, daunorubicin (Dau)-linked conjugates with or without butyrated Lys in position 4 (4Lys(Bu)) at a molecular level in a human colorectal carcinoma cell line. Cell viability was measured by impedimetry, cellular uptake and apoptosis were studied by flow cytometry, and the expression of apoptosis-related genes was analyzed by qRT-PCR. The modification with 4Lys(Bu) resulted in an increased cytotoxic and apoptotic effects and cellular uptake of the GnRH-I and GnRH-III conjugates. Depending on the ...