TY - JOUR. T1 - Adherence to treatment with protease inhibitors and therapeutic outcome in an unselected cohort of HIV-infected patients. T2 - A retrospective study. AU - Lazzarini, L.. AU - Lanzafame, M.. AU - Polo, A.. AU - Vento, S.. AU - Concia, E.. PY - 2000. Y1 - 2000. N2 - Objectives: A retrospective study was carried out to assess the relationship between medication adherence to protease inhibitors and therapeutic outcome in an unselected cohort of HIV infected patients. Methods: 173 patients, undergoing a triple antiretroviral treatment including a protease inhibitor, were recruited. Adherence was assessed through an antiretroviral medicine register. Results: Non-adherence was found in 26.5% of patients on indinavir, in 29% of patients on ritonavir and in 25.7% of patients on saquinavir. No immunological and clinical failure was recorded during the study. At the end of the study, the average plasmatic viremia was lower in adherent than in non-adherent patients (11,587 vs 21,258 ...
Jehan, I., Harris, H., Salat, S., Zeb, A., Mobeen, N., Pasha, O., ... Goldenberg, R. L. (2009). Neonatal mortality, risk factors and causes: A prospective population-based cohort study in urban Pakistan. Bulletin of the World Health Organization, 87(2), 130-138. DOI: 10.2471/BLT.08.050963 ...
Clinical trial for Mother to Child Transmission of HIV , Prospective Observational Cohort Study on Mother to Child Transmission HIV1/HIV2 and Prevention
article{e1d486dc-0d2e-4f48-b547-d6542d967ba0, abstract = {,p,Prospective observational studies have shown previously that study participants have lower morbidity and mortality than non-participants. The aim of the current study was to determine whether participants in a prospective cohort study on melanoma have a different incidence and mortality of melanoma compared with non-participants and the background population. Information was collected from Swedish National Registers on participants (n = 30,501) and non-participants (n = 10,499) in the Melanoma In Southern Sweden (MISS) study and the background population (n = 243,032). Hazard ratios were calculated for overall incidence of cancer and melanoma, and all-cause and melanoma-specific mortality, using Cox regression. Participants had a lower overall incidence of cancer and all-cause mortality than non-participants and the background population. There was no difference in incidence of melanoma or melanoma-specific characteristics between ...
Survival rates in kidney cancer have improved little over time, and diabetes may be an independent risk factor for poor survival in kidney cancer. We sought to determine whether medications with putative anti-neoplastic properties (statins, metformin and non-steroidal anti-inflammatory drugs (NSAIDs)) are associated with survival in diabetics with kidney cancer. We conducted a population-based cohort study utilizing linked healthcare databases in Ontario, Canada. Patients were aged 66 or older with newly diagnosed diabetes and a subsequent diagnosis of incident kidney cancer. Receipt of metformin, statins or NSAIDs was defined using prescription claims. The primary outcome was all-cause mortality and the secondary outcome was cancer-specific mortality. We used multivariable Cox proportional hazard regression, with medication use modeled with time-varying and cumulative exposure analyses to account for intermittent use. During the 14-year study period, we studied 613 patients. Current statin use ...
A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues. The association between increased BMI and homozygosity for the minor allele was first observed in data from a genome-wide association scan of 86,604 SNPs in 923 related individuals from the Framingham Heart Study offspring cohort. The association was reproduced in four additional cohorts, but was not seen in a fifth cohort. To further assess the general reproducibility of this association, we genotyped rs7566605 in nine large cohorts from eight populations across multiple ethnicities (total n = 16,969). We tested this variant for association with BMI in each sample under a recessive model using family-based, population-based, and case-control designs. We observed a significant (p , 0.05) association in five cohorts but saw no association in three other cohorts. There was variability in the strength of association evidence across ...
TY - JOUR. T1 - Long-term mortality in HIV-infected individuals 50 years or older. T2 - a nationwide, population-based cohort study. AU - Legarth, Rebecca. AU - Ahlström, Magnus G. AU - Kronborg, Gitte. AU - Larsen, Carsten S. AU - Pedersen, Court. AU - Pedersen, Gitte. AU - Mohey, Rajesh. AU - Gerstoft, Jan. AU - Obel, Niels. PY - 2016. Y1 - 2016. N2 - BACKGROUND: Although the prevalence of HIV-infection among individuals ≥ 50 years of age has increased, the impact of HIV-infection on risk of death in this population remains to be established. Our aim was to estimate long-term mortality among HIV-infected individuals who were 50 years or older, when compared to an individually-matched cohort from the background population.METHODS: Population-based cohort-study including HIV-infected individuals ≥ 50 years, who were alive one year after HIV-diagnosis (n=2,440) and a comparison cohort individually-matched by age and gender extracted from the background population (n=14,588). Cumulative ...
Maria Lorenzi successfully defended her M.Sc. project entitled Analysis of Occupational Cohort Data Using Exposure as a Continuous Time-dependent Variable on 3 August 2005.. In occupational cohort studies, a group of workers is followed over time, and disease and work history information are collected for each individual in order to determine whether exposure to a particular substance is linked to differences in mortality or disease incidence rates. These studies are typically analyzed by treating cumulative exposure as a categorical variable and then comparing disease or mortality rates between different exposure groups. A main shortfall of such analyses is a heavy dependence on the choice of these exposure categories, as certain choices may mask or exaggerate important features of the dose-response curve. In this project, an extension to the Cox proportional hazards model is used to treat cumulative exposure as a continuous variable and model the dose-response curve nonparametrically for a ...
Maria Lorenzi successfully defended her M.Sc. project entitled Analysis of Occupational Cohort Data Using Exposure as a Continuous Time-dependent Variable on 3 August 2005.. In occupational cohort studies, a group of workers is followed over time, and disease and work history information are collected for each individual in order to determine whether exposure to a particular substance is linked to differences in mortality or disease incidence rates. These studies are typically analyzed by treating cumulative exposure as a categorical variable and then comparing disease or mortality rates between different exposure groups. A main shortfall of such analyses is a heavy dependence on the choice of these exposure categories, as certain choices may mask or exaggerate important features of the dose-response curve. In this project, an extension to the Cox proportional hazards model is used to treat cumulative exposure as a continuous variable and model the dose-response curve nonparametrically for a ...
Background: The prognostic value of erythrocyte levels of the n-6 fatty acids (FAs) for total mortality and cardiovascular disease (CVD) outcomes remains an open question. Methods: We examined CV outcomes and death in 2500 individuals in the Framingham Heart Study Offspring cohort without prevalent CVD (mean age 66 years, 57% women) as a function of baseline levels of different length n-6 FAs (18 carbon, 20 carbon and 22 carbon) in the erythrocyte membranes. Clinical outcomes were monitored for up to 9.5 years (median follow up, 7.26 years). Cox proportional hazards models were adjusted for a variety of demographic characteristics, clinical status and RBC n-6 and long chain n-3 FA content. Results: There were 245 CV events, 119 CHD events, 105 ischemic strokes, 58 CVD deaths, and 350 deaths from all causes. Few associations between either mortality or CVD outcomes were observed for the n-6 FAs, with those that were observed becoming non-significant after adjusting for n-3 FA levels. Conclusions: Higher
Preservation of the Semantic Verbal Fluency Advantage in a Large Population-Based Sample: Normative Data from the TILDA Study - Volume 22 Issue 5 - Roisin M. Vaughan, Robert F. Coen, RoseAnne Kenny, Brian A. Lawlor
Background Dipeptidyl-peptidase-4 inhibitors (DPP4Is) are drugs for the treatment of type 2 diabetes mellitus (T2DM). There is increasing evidence that DPP4Is may result in suppression of the immune system and may increase the risk of infections such as pneumonia. Aim of this study was to evaluate the association between the use of DPP4Is and the risk of pneumonia in a population-based study. Methods We conducted a population-based cohort study using data from the worlds largest primary care database, the UK Clinical Practice Research Datalink (CPRD). We selected all users of non-insulin antidiabetic drugs (NIADs), including DPP4Is, between 2007 and 2012. To each NIAD user, we matched randomly selected non-users. The NIAD users first prescription defined the index date, which was then assigned to the matched non-users. Patients were followed from their first prescription until end of data collection or the first event of pneumonia, whichever came first. Cox regression analysis estimated the
Morna Cornell and colleagues investigate differences in mortality for HIV-positive men and women on antiretroviral therapy in South Africa.
BACKGROUND: Caffeine intake has been inversely associated with Parkinsons disease (PD) risk. This relationship may be modified by polymorphisms of glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) and cytochrome P450 1A2 (CYP1A2), but the results of previous studies have been inconsistent. METHOD: We examined the interaction of caffeine intake with GRIN2A-rs4998386 and CYP1A2-rs762551 polymorphisms in influencing PD risk among 829 incident cases of PD and 2,754 matched controls selected among participants in the following 3 large prospective ongoing cohorts: the Nurses Health Study, the Health Professionals Follow-up Study, and the Cancer Prevention Study II Nutrition Cohort ...
article{8645532, author = {Seibold, Petra and Webb, Adam and Aguado-Barrera, Miguel E. and Azria, David and Bourgier, Celine and Brengues, Muriel and Briers, Erik and Bultijnck, Renée and Calvo-Crespo, Patricia and Carballo, Ana and Choudhury, Ananya and Cicchetti, Alessandro and Claßen, Johannes and Delmastro, Elena and Dunning, Alison M. and Elliott, Rebecca M. and Fachal, Laura and Farcy-Jacquet, Marie-Pierre and Gabriele, Pietro and Garibaldi, Elisabetta and Gómez-Caamaño, Antonio and Gutiérrez-Enríquez, Sara and Higginson, Daniel S. and Johnson, Kerstie and Lobato-Busto, Ramón and Mollà, Meritxell and Müller, Anusha and Payne, Debbie and Peleteiro, Paula and Post, Giselle and Rancati, Tiziana and Rattay, Tim and Reyes, Victoria and Rosenstein, Barry S. and De Ruysscher, Dirk and De Santis, Maria Carmen and Schäfer, Jörg and Schnabel, Thomas and Sperk, Elena and Symonds, R. Paul and Stobart, Hilary and Taboada-Valladares, Begoña and Talbot, Christopher J. and Valdagni, Riccardo ...
Participation rates in large cohort studies have decreased during the last 2 decades. The consequences of this trend for relative risk estimation are unknown. The impact of a low participation rate (30%) on the Danish National Birth Cohort was examined among 49,751 women from the source population, including 15,373 participants in the cohort study. On the basis of independent data collection, we estimated odds ratios (ORs) in the source population and among participants for 3 exposure-risk associations: (a) in vitro fertilization and preterm birth, (b) smoking during pregnancy and birth of a small-for-gestational-age infant, and (c) prepregnancy body mass index and antepartum stillbirth. The effect of nonparticipation was described by a relative odds ratio (ROR), calculated as the OR(participants)/OR(source population). Two methods for calculation of confidence intervals for the relative odds ratio also were assessed. The effect of nonparticipation on the selected ORs was small. The relative ORs ...
This study hypothesized that HISD prekindergarten participation consistently correlated with better educational outcomes for students. Taking into account students age differences through kindergarten enrollment, propensity score matching controlled for students background characteristics. Three cohorts of students in this study were eligible or attended HISD prekindergarten during the 2001-2002 (Cohort I), 2002-2003 (Cohort II), and 2003-2004 (Cohort III) academic years. The study found that kindergarten students in Cohorts I, II, and III outperformed students who did not attend HISD prekindergarten on nationally-normed Stanford and Aprenda reading and mathematics tests, indicating a statistically significant positive effect of HISD prekindergarten in the short-term. HISD prekindergarten had extended effects for Cohort II students, given that they consistently outperformed non-HISD prekindergarten students at targeted grades third, fifth, and seventh. Long-term effects related to
A large prospective cohort study published in Stroke by researchers from several universities in Japan has found that people who drank four or more cups of green tea a day had a 20% lower stroke risk compared to those who seldom drank it. The study investigated the dietary habits of 81978 participants who were involved in an ongoing cohort study of Japanese adults aged 40 to 69 which focused on lifestyle and the risk of cardiovascular disease and cancer. Using a food frequency questionnaire the participants recorded their consumption of various foods and drinks including green tea and coffee. During the follow up period of 13 years there were 3425 strokes and 910 incidents of coronary heart disease. The scientists found that those who drank two to three cups of green tea a day were 14% less likely to have any type of stroke than those who seldom or never drank it, people who drank four or more cups of green tea a day were 20% less likely to have any type of stroke than those who seldom or never ...
A prospective cohort study follows a group or of individuals who are initially free of the outcome of interest. Individuals in a cohort generally share some underlying characteristic, such as age, sex, or exposure to a . Some studies may comprise several different cohorts. The study is usually conducted for a predetermined period, long enough for some members of the cohort to develop the outcome of interest. Individuals who developed the outcome are compared with those who did not. The report of the study should include a description of the cohort and the length of follow-up, what were measured and
A prospective cohort study follows a group or of individuals who are initially free of the outcome of interest. Individuals in a cohort generally share some underlying characteristic, such as age, sex, or exposure to a . Some studies may comprise several different cohorts. The study is usually conducted for a predetermined period, long enough for some members of the cohort to develop the outcome of interest. Individuals who developed the outcome are compared with those who did not. The report of the study should include a description of the cohort and the length of follow-up, what were measured and
The study population was comprised of 17,059 patients. The VC rate was higher in the overall contemporary cohort compared with the historical cohort (adjusted rates: 2.91% vs. 1.98%; odds ratio [OR], 1.48; 95% confidence interval [CI], 1.17-1.89; p = 0.001). In the contemporary cohort, radial access was associated with fewer VCs compared with femoral access (adjusted rates: 1.44% vs. 4.19%; OR, 0.33; 95% CI, 0.23-0.48; p < 0.001). There was a higher likelihood of VCs in association with FA in the contemporary cohort compared with the historical cohort (adjusted rates: 4.19% vs. 1.98%; OR, 2.16; 95% CI, 1.67-2.81; p < 0.001). This finding was consistent for both diagnostic and therapeutic catheterizations separately. ...
OBJECTIVES: Concern about the health hazards of exposure to workers in the ferroalloy industry has initiated this historical cohort study. The aim was to examine the mortality pattern among male employees in 12 Norwegian ferroalloy plants. METHODS: All men employed for at least six months who started their first employment during 1933-91 were eligible for the cohort. Deaths observed during 1962-90 were compared with expected figures calculated from national mortalities. Internal comparisons of rates were performed by Poisson regression analysis. The final cohort comprised 14,730 male employees who were observed for 288,886 person-years. RESULTS: Mortality from all causes of death was slightly increased (3390 deaths, standardised mortality ratio (SMR) 1.08, 95% confidence interval (95% CI) 1.04-1.11). Regression analysis of total mortality showed a significant negative trend for the rate ratios with increasing duration of employment. An increased mortality was found among employees in urban ...
The Original Cohort of the Framingham Heart Study consisted of 5,209 respondents of a random sample of 2/3 of the adult population of Framingham, Massachusetts, 30 to 62 years of age by household, in 1948. Exam 32 for the Original Cohort ended in April of 2014.. ...
Case series are a commonly reported study design, but the label "case series" is used inconsistently and sometimes incorrectly. Mislabeling impairs the appropriate indexing and sorting of evidence.. This article tries to clarify the concept of case series and proposes a way to distinguish them from cohort studies. In a cohort study, patients are sampled on the basis of exposure and are followed over time, and the occurrence of outcomes is assessed. A cohort study may include a comparison group, although this is not a necessary feature. A case series may be a study that samples patients with both a specific outcome and a specific exposure, or one that samples patients with a specific outcome and includes patients regardless of whether they have specific exposures. Whereas a cohort study, in principle, enables the calculation of an absolute risk or a rate for the outcome, such a calculation is not possible in a case series. ...
This 2002 report presents the results of the mortality cohorts implemented through the EMCDDA multi-site study. The report contains: the descriptions of the cohorts, the standardised mortality rates (general and cause-specific, when possible), the standardised mortality ratios (SMR), a survival analysis of cohorts participants by age and site, and a univariate and multivariate analysis of factors related to mortality.. ...
How representative participants in this study were in relation to the original cohort was tested using χ2 tests. Separate analyses were carried out by sex as BMD, skeletal size, and rates of bone loss are known to differ between men and women. Lifecourse effects on adult health have previously been shown to differ by sex for this and other cohorts.11,22,23 Furthermore, the inclusion of variables such as age at menarche, and number of pregnancies prevents the use of a combined lifecourse model. Eleven twins were excluded from all analyses because of the differences in fetal development for multiple births and the fact that data contributed by co-twins are not independent.. Chronic infection in childhood, hormone replacement therapy and physical activity were defined as binary variables. Social class, position in family, alcohol consumption, number of acute illnesses in childhood, quartiles of ranked adult dietary intake of vitamins C and D, protein and calcium, and number of pregnancies were ...
Mansell, Toby, Ponsonby, Anne-Louise, Collier, Fiona, Burgner, David, Pezic, Angela, Vuillermin, Peter, Ryan, Joanne, Saffery, Richard, Carlin, John, Allen, Katie, Tang, Mimi, Ranganathan, Sarath, Burgner, David, Dwyer, Terry and Sly, Peter 2020, Methylation of the LEP gene promoter in blood at 12 months and BMI at 4 years of age-a population-based cohort study, International journal of obesity, vol. 44, pp. 842-847, doi: 10.1038/s41366-020-0553-3. ...
PubMed journal article: Bias correction of estimates of familial risk from population-based cohort studies. Download Prime PubMed App to iPhone, iPad, or Android
BACKGROUND: Distinguishing temporal patterns of depressive symptoms during pregnancy and after childbirth has important clinical implications for diagnosis, treatment, and maternal and child outcomes. The primary aim of the present study was to distinguish patterns of chronically elevated levels of depressive symptoms v. trajectories that are either elevated during pregnancy but then remit after childbirth, v. patterns that increase after childbirth.. METHODS: The report uses latent growth mixture modeling in a large, population-based cohort (N = 12 121) to investigate temporal patterns of depressive symptoms. We examined theoretically relevant sociodemographic factors, exposure to adversity, and offspring gender as predictors.. RESULTS: Four distinct trajectories emerged, including resilient (74.3%), improving (9.2%), emergent (4.0%), and chronic (11.5%). Lower maternal and paternal education distinguished chronic from resilient depressive trajectories, whereas higher maternal and partner ...
TY - JOUR. T1 - Recovery from mental ill health in an occupational setting. T2 - A cohort study in Japan. AU - Mino, Yoshio. AU - Shigemi, Jun. AU - Tsuda, Toshihide. AU - Yasuda, Nobufumi. AU - Babazono, Akira. AU - Bebbington, Paul. PY - 2000/3. Y1 - 2000/3. N2 - Objectives: The purpose of this study is to clarify the degree of recovery from mental ill health in occupational settings and the nature of perceived job stress associated with recovery. Methods: A 1-year cohort study was carried out in 287 of 763 workers who scored 8 or more on the General Health Questionnaire (GHQ-30), and the proportion recovering during the year was compared according to the presence of individual perceived job stress items. To control confounding factors, multiple logistic analysis was used. Results: Recovery from mental ill health was observed in 48.7% after the first 6 months and in 66.1% after 1 year. During the first 6-month period, no identified job stress item was associated with recovery. During the ...
Methods The Million Women Study is a large population-based prospective cohort study of middle-aged UK women. This analysis is based on 372 542 women who reported their birthweight, current body size, and other information in a follow-up survey administered approximately 3 years after recruitment (mean age 58 years at follow-up). Logistic regression was used to estimate relative risk for being obese in adulthood (body mass index,30 kg/m2) by birthweight, both unadjusted and adjusted for reported adult height, parental heights, and a range of social and lifestyle factors, including socio-economic status, parental smoking at birth, being breast fed, reproductive history and health behaviours. ...
SIGA Completes Enrollment and Dosing in Final Cohort of Phase I Study of IV Formulation of TPOXX® (tecovirimat) to Treat Smallpox
Bischoff-Ferrari, H. A., Dawson-Hughes, B., Baron, J. A., Kanis, J. A., Orav, E. J., Staehelin, H. B., Kiel, D. P., Burckhardt, P., Henschkowski, J., Spiegelman, D., Li, R., Wong, J. B., Feskanich, D. and Willett, W. C. (2011), Milk intake and risk of hip fracture in men and women: A meta-analysis of prospective cohort studies. J Bone Miner Res, 26: 833-839. doi: 10.1002/jbmr.279 ...
SIGA Technologies has begun enrolling the second and final cohort of healthy subjects for Phase III clinical study for its lead drug candidate, TPOXX
A maximum of 56 healthy adult (male and female) subjects will participate in this study, in two stages. In Stage 1, the Single-Ascending Dose (SAD) phase of the study will have up to six cohorts with 4 subjects (3 receiving TKM-100201 and 1 receiving saline placebo) in each cohort. Additional cohorts may be enrolled if a maximum tolerated dose (MTD) is not established after the initial six cohorts. In Stage 2, the Multiple-Ascending Dose (MAD) portion of the study will have up to three cohorts with four subjects (3 receiving TKM-100201 and 1 receiving saline placebo) in each cohort. Additional cohorts may be enrolled if a maximum tolerated dose (MTD) is not established after the initial three cohorts ...
Parkinsons Disease and Risk of Fracture: A Meta-Analysis of Prospective Cohort Studies. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
A maximum of 56 healthy adult (male and female) subjects will participate in this study, in two stages. In Stage 1, the Single-Ascending Dose (SAD) phase of the study will have up to six cohorts with 4 subjects (3 receiving TKM-100201 and 1 receiving saline placebo) in each cohort. Additional cohorts may be enrolled if a maximum tolerated dose (MTD) is not established after the initial six cohorts. In Stage 2, the Multiple-Ascending Dose (MAD) portion of the study will have up to three cohorts with four subjects (3 receiving TKM-100201 and 1 receiving saline placebo) in each cohort. Additional cohorts may be enrolled if a maximum tolerated dose (MTD) is not established after the initial three cohorts ...
Person-years at risk were calculated from the date of the first CD4 count within 3 months after 3 years of viral suppression to the earlier of time of death, loss to follow-up, or end of observation. We estimated mortality rates and Kaplan-Meier plots according to CD4 count at the end of the 3-year virally suppressed period (≤200, 201-350, 351-500, or >500 cells/μL) and used Cox regression to estimate hazard ratios (HRs) for death according to these CD4 count groups. All analyses were adjusted for the covariates listed above (AIDS events in this analysis were up to the end of the virally suppressed period) and stratified by cohort. We used Cox regression to compare individuals with CD4 counts ≤200 cells/μL and >200 cells/μL at the end of the suppressed period within strata defined by age at start of virally suppressed period, route of infection, AIDS status, and CD4 at start of suppressed period. In sensitivity analyses, we used a cutoff value of 50 copies/mL to define viral suppression ...
APPROACH is a large inception cohort study which captures all patients undergoing cardiac catheterization in Alberta, Canada. We used data on 11,804 patients from this study to examine the two year survival experience of diabetics vs. non-diabetics, while controlling for covariates such as left ventricular ejection fraction, coronary anatomy, sociodemographic variables, and comorbidities. Here, we present a comparison of two methods for calculating covariate-adjusted survival curves. The most commonly-used method for generating such curves is the "average covariate method", in which the average values of covariates of interest are entered into a proportional hazards regression equation to generate adjusted survival estimates. We used data from the APPROACH study to compare the survival curves generated by the "average covariate method" with those generated by a newer method - the "corrected group prognosis method" - in which a survival curve for each level of covariates is calculated, after ...
El Paso, TX. Cohort Studies, is a study design where one or more people (called cohorts) are followed and subsequent status evaluations with respect to a disease or outcome are conducted to determine which participants exposure characteristics (risk factors) are associated.
MHRP has been conducting HIV cohort studies in Africa and Thailand since the 1990s. These studies lay the groundwork for future research and help inform researchers about disease incidence, viral diversity and host genetics and treatment outcomes. The studies also gauge interest and willingness of communities to participate in future clinical trials.
REPORTS AVAILABLE JPND call 2014: Working Groups to Inform Cohort Studies in Neurodegenerative Disease Research Increasing the impact of longitudinal
Table 4 shows a comparison of DPB1 allele frequencies for the two groups of DAISY samples. High type 1 diabetes risk individuals (DR3/4-DQB1*0302; DR4≠DRB1*0403) were selected from both the General Population Cohort (GPC) and the Sibling-Offspring Cohort (SOC) (see research design and methods). This study design differs from the others in that the comparison is not between patients and control subjects but between HLA-matched individuals with or without a type 1 diabetic relative. The observed higher type 1 diabetes risk for high-risk SOC subjects than for high-risk GPC subjects leads to the testable hypothesis that the SOC subjects are enriched in non-DR-DQ susceptibility alleles.. The data show that DPB1*0301 is significantly overrepresented in the SOC (P = 0.04) compared with the GPC, whereas DPB1*0402 is underrepresented in the SOC (P = 0.002) compared with the GPC, consistent with previous observations for these alleles. DPB1*0202 was rare and did not differ significantly between the two ...
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This large national cohort study followed-up pregnant women admitted to hospital and found to have laboratory-confirmed influenza A(H1N1) 2009 infection during the autumn-winter wave of the 2009 pandemic. The main objective was determining any adverse pregnancy outcomes attributable to the infection.. ...
This large national cohort study followed-up pregnant women admitted to hospital and found to have laboratory-confirmed influenza A(H1N1) 2009 infection during the autumn-winter wave of the 2009 pandemic. The main objective was determining any adverse pregnancy outcomes attributable to the infection.. ...
To me, the power of the LGBT network-which Ive been a part of since my early days at BCG-is that it connected me to a wide variety of people from different cohorts across the world, it taught me the value of diversity, and it showed me the impact leaders with a vision can have.
Growing levels of both obesity and chronic disease in the general population pose a major public health problem. In the UK, an innovative health and weight cohort trials facility, the South Yorkshire Cohort, is being built in order to provide robust evidence to inform policy, commissioning and clinical decisions in this field. This protocol reports the design of the facility and outlines the recruitment phase methods. The South Yorkshire Cohort health and weight study uses the cohort multiple randomised controlled trial design. This design recruits a large observational cohort of patients with the condition(s) of interest which then provides a facility for multiple randomised controlled trials (with large representative samples of participants, long term outcomes as standard, increased comparability between each trial conducted within the cohort and increased efficiency particularly for trials of expensive interventions) as well as ongoing information as to the natural history of the condition and
2011 (Engelska)Ingår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 37, nr 5, s. 1285-1287Artikel i tidskrift (Refereegranskat) Published ...
In a population based, prospective cohort study, 214 Japanese men and 152 white men aged 40-49 years at baseline (2002-2006) with coronary calcium score (CCS)=0 were re-examined for CAC in 2007-2010. Among these, 175 Japanese men and 113 white men participated in the follow-up exam. Incident cases were defined as participants with CCS≥10 at follow-up. A relative risk regression analysis was used to model the incidence rate ratio between the Japanese and white men. The incidence rate ratio was first adjusted for potential confounders at baseline and then further adjusted for serum LCn3PUFAs at baseline ...
Scientific Experts, Genomes and Genes, Publications, Research Topics, Species about COHORT STUDY OF GENETIC SUSCEPTIBILITY TO BREAST CANCER
These conclusions are broadly regular with printed reports on the same cohort, whi1022958-60-6ch showed antibody ranges to the complete duration ectodomain of
Tabah A, Koulenti D, Laupland K, Misset B, Valles J, Bruzzi de Carvalho F, Paiva JA, Cakar N, Ma X, Eggimann P, Antonelli M, Bonten MJ, Csomos A, Krueger WA, Mikstacki A, Lipman J, Depuydt P, Vesin A, Garrouste-Orgeas M, Zahar JR, Blot S, Carlet J, Brun-Buisson C, Martin C, Rello J, Dimopoulos G, Timsit JF (2012) Characteristics and determinants of outcome of hospital-acquired bloodstream infections in intensive care units: the EUROBACT International Cohort Study. Intensive Care Med 38:1930- ...
Noncrossing partitions are an interesting combinatorial object which play an important role in various topic of mathematics, such as in free probability. In this talk, we focus on their importance for the classification of thick subcategories in certain triangulated categories: Ingalls and Thomas have shown that the lattice of non-crossing partitions of a regular polygon with n+2 vertices is in one-to-one correspondence with the lattice of thick subcategories in the bounded derived category of representations of a Dynkin quiver of type A with n vertices. In joint work with Stevenson we provide an infinite version of this result by showing that the lattice of non-crossing partitions of the infinity-gon with a point at infinity is isomorphic to the lattice of thick subcategories in the bounded derived category of graded modules over the dual numbers.. ...
An epidemiologic study that observes subjects in differently exposed groups and compares the incidence of symptoms. Although ordinarily prospective in nature, such a study is sometimes carried out retrospectively, using historical data. See prospective study. Prospective study - аn inquiry in which groups of individuals are selected in terms of whether they are or are not exposed to certain factors, and then followed over time to determine differences in the rate at which disease develops in relation to exposure to the factor. Also called cohort study. ...
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice to Update and Clarify Budgetary Limits for PAR-12-222, Cohort Studies of HIV/AIDS and Substance Use (U01) NOT-DA-13-006. NIDA
Hospitalisation for pneumonia increases both short-term and long-term cardiovascular risk, according to this matched-cohort study (JAMA 2015;313:264.doi:10.1001/jama.2014.18229). Researchers performed secondary data analysis from the Cardiovascular Health Study (mean patient age 73 years) and from the Atherosclerosis Risk in Communities Study (mean patient age 56 years) identifying 1271 patients hospitalised with pneumonia. Each patient was matched with two controls and all patients were followed up for 10 years and observed for occurrences of cardiovascular disease. The highest risk for cardiovascular disease was seen in the first year and the risk was still increased in subsequent years, even after adjusting for multiple confounders. Patients in the older cohort were found to have a fourfold increased risk in the first 30 days, compared with controls. The risk remained raised over the 10 years with a 1.86-fold increased risk at 10 years being reported. In the younger cohort, the risk was ...
Biological samples are collected routinely by many cohort studies. This workshop addresses some of the key issues in working with human tissue.
The Reserve against Disability in Early MS (RADIEMS) cohort study is an NIH-funded prospective study of risk and protective factors related to disease and
The Group has made major contributions through the analysis of large collaborative national and international cohorts to describing the impact of multi-drug anti-HIV therapy and understanding its underlying mechanisms of action. Recently it has played a leading part in evaluating the effects of HIV related therapies that have led to changes in treatment guidelines world-wide. Find out more.... ...
Published January 14, 2018 WINDOW ROCK - The Navajo Birth Cohort Study, which was about to wrap up this year, was awarded a $4.4 million grant from the National Institutes of Health, which will not only extend the study another five years but considerably broaden its scope. The program will now fall under a national study called […]. The post Birth Cohort Study to Continue, Expand with New Grant appeared first on Native News Online.. Follow this story. ...
Sometimes, when youre buried in data, statistics, graphs and reports, analytics work can feel a tad dry. Personally, I tolerate creating reports (generally by automating them) but find analysis (identifying why the data is the way it is) rather compelling. In this first of several posts on cohort analysis Im going to explore why dividing your visitors…
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The technique involves identifying genetic variants that mimic the action of a drug on its intended target and then checking in large patient cohorts whether these variants are associated with risk of other conditions, such as cardiovascular disease.
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In hospitalized pregnant women with severe or critical COVID-19 infection, admission typically occurred about 7 days after symptom onset, and the duration of hospitalization was 6 days (6 severe versus 12 critical). Critically ill women had a high rate of ARDS, and there was one case of cardiac arre …
There was a decline in the mean age of enrollees by month of enrollment from 46.5 years to 42.2 years in the first five months of 2014,…Marketplace enrollees had very different starting levels of medication use depending on when they enrolled (Exhibit 2). In their first month of enrollment, January enrollees filled 0.86 prescriptions per member per month. Successive cohorts (by month of enrollment) had a lower mean number of fills in their first month of enrollment (0.72 for February enrollees, 0.69 for March, 0.61 for April, and only 0.46 for May). Each group experienced a substantial increase in medication use over the study period, although the groups enrolling in later months had consistently lower medication use than the early enrollees even by September 2014 ...
A user writes: Hi, I am an Eventus user through WRDS. I want to add a new factor to the Fama-French calendar time regression, and...
The purpose of this study is to test the safety of venetoclax and to find the highest dose of venetoclax that can be given safely when it is combined with one
The BUPA cohort study was set up to look at risk factors for cancer and mortality, with an emphasis on the risks of smoking. 22,000 men aged 35-64 years who attended the British United Provident Asso
This is a phase 1b study for patients with metastatic (cancer has spread to various parts of the body) melanoma and ovarian cancer. The main purpose is to
B. ﹗例﹗一開始選定一群沒有病的人3分成暴露組與非暴露組3暴露組吸菸3非暴露組不吸菸330年後再進行追蹤比較兩組的疾病發生率 ...
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Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics. . ...
Joester, J., Vogler, C., Chang, K., Hilmer, S. (2010). Hypnosedative use and predictors of successful withdrawal in new patients attending a falls clinic: a retrospective, cohort study. Drugs and Aging, 27(11), 915-924. [More Information] ...
Background. Comparative cohort studies are often conducted to identify novel therapeutic strategies or prognostic factors for ventilator-associated pneumonia (VAP). We aimed to evaluate the power of such studies to provide clinically and statistically significant conclusions with regard to mortality differences.. Methods. We searched in PubMed and Scopus for comparative cohort studies that evaluated mortality in patients with VAP. We calculated the central estimates and corresponding 95% confidence intervals (CIs) for mortality differences between compared patient groups. We also calculated the statistical power of the included studies to detect a difference in mortality that corresponds to a risk ratio of 0.80.. Results. We identified 39 (20 prospective) comparative cohort studies on VAP as eligible for inclusion in this analysis. The median absolute risk difference in mortality between compared groups was 10% (interquartile range [IQR], 5%-18%), and the median width of the 95% CI of the ...
TY - JOUR. T1 - Osteoporosis increases subsequent risk of gallstone. T2 - A nationwide population-based cohort study in Taiwan. AU - Klahan, Sukhontip. AU - Kuo, Chun Nan. AU - Chien, Shu-Chen. AU - Lin, Yea Wen. AU - Lin, Chun Yi. AU - Lin, Chia Hsien. AU - Chang, Wei Chiao. AU - Lin, Ching I.. AU - Hung, Kuo Sheng. AU - Chang, Wei Pin. PY - 2014/11/18. Y1 - 2014/11/18. N2 - Background: Osteopontin (OPN) is a pro-inflammatory cytokine which is expressed in various tissues. It participates in the bone remodeling process and stimulates bone resorption by osteoclasts. It is also a core protein of cholesterol gallstones. We hypothesized osteoporotic patients might have higher risk in developing gallstones and conducted a population-based study to examine the risk of developing gallstone in osteoporotic patients in Taiwan. Methods: A total of 1,638 patients diagnosed with osteoporosis between 2003 and 2005 were identified in the National Health Insurance Research Database. A comparison cohort ...
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Thank you for your interest in spreading the word on CMAJ.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
ABSTRACTObjectiveTo externally validate four commonly used rules in computed tomography (CT) for minor head injury.DesignProspective, multicentre cohort study.SettingThree university and six non-university hospitals in the Netherlands.ParticipantsConsecutive adult patients aged 16 years and over who
There is growing evidence that early growth influences bone mass in later life but most studies are limited to birth weight and/or early infant growth and dual-energy X-ray absorptiometry (DXA) measurements. In a British birth cohort study with prospective measures of lifetime height and weight, we investigated the growth trajectory in relation to bone in males (M) and females (F) at 60 to 64 years old. Outcomes were DXA measures of hip and spine areal bone density (aBMD) (n = 1658) and pQCT measures of distal and diaphyseal radius cross-sectional area (CSA), strength, and volumetric bone density (vBMD) (n = 1350 of the 1658). Regression models examined percentage change in bone parameters with standardized measures of birth weight, height, and weight. A series of conditional growth models were fitted for height and weight gain (using intervals: birth-2, 2-4, 4-7, 7-15, 15-20, 20-36, and 36-64 years) and height gain (using intervals: 2-4, 4-7, 7-15, and 15-36 years). Birth weight was positively related
TY - JOUR. T1 - Size at birth and height in early adolescence. T2 - A prospective birth cohort study. AU - Araújo, Cora L P. AU - Hallal, Pedro C.. AU - Nader, Gisele A.. AU - Menezes, Ana Maria B. AU - Victora, Cesar G.. PY - 2008/4. Y1 - 2008/4. N2 - The aim of this study was to evaluate the association between size at birth (birthweight and birth length) and height in early adolescence in a prospective birth cohort study in Pelotas, Rio Grande do Sul, Brazil. Interviews were carried out in 1993, including measurements of birthweight and length, and in 2004-2005, including measurements of weight and height. This analysis includes 4,452 individuals, with a mean age of 11.3 years (standard deviation - SD = 0.3), representing a follow-up rate of 87.5%. Mean height at 11 years was 145.8 cm (SD = 7.9), or 144.9 cm (SD = 7.7) in boys and 146.8 cm (SD = 7.9) in girls. Birthweight and birth length were positively associated with height in early adolescence in the crude analysis, but after adjustment ...
Potential Conflicts of Interest: None disclosed. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M11-2633. Reproducible Research Statement:Study protocol: Not available. Statistical code: Available from Dr. Jepsen (e-mail, mailto:[email protected]). Data set: The Danish National Board of Health (www.sst.dk) extracts data from Denmarks publicly available health care registries on request. The instructions given to the Board of Health to identify the nationwide cohort are available from Dr. Jepsen. Data for the Aarhus cohort are not available. Requests for Single Reprints: Peter Jepsen, MD, PhD, Aarhus University Hospital, Department of Hepato-Gastroenterology, Nørrebrogade 44, Aarhus 8000 C, Denmark; e-mail, mailto:[email protected] Current Author Addresses: Drs. Jepsen, Ott, and Vilstrup: Aarhus University Hospital, Nørrebrogade 44, Aarhus 8000 C, Denmark. Dr. Andersen: University of Copenhagen, O. Farimagsgade 5, PB 2099, Copenhagen K 1014, Denmark.. Dr. ...
Epidemiologic findings are inconsistent regarding risk for breast cancer related to dairy consumption. We performed a meta-analysis of prospective cohort studies to examine the association between diary product consumption and risk of breast cancer. A PubMed database search through January 2011 was performed for relevant studies. We included prospective cohort studies that reported relative risks with 95% confidence intervals for the association of dairy consumption and breast cancer risk. A random effects model was used to calculate the summary risk estimates. We identified 18 prospective cohort studies eligible for analysis, involving 24,187 cases and 1,063,471 participants. The summary relative risk of breast cancer for the highest intake of total dairy food compared with the lowest was 0.85 (95% confidence interval: 0.76-0.95), with evidence of heterogeneity (P = 0.01, I 2 = 54.5%). For milk consumption, the summary relative risk was 0.91 (95% confidence interval: 0.80-1.02), and substantial
Background To assess relationships between age at first birth and cardiovascular risk factors in a large longitudinal study of men and women. By assessing associations for both genders, we were able to investigate biological versus social and behavioural explanations from early life through to adulthood. Methods Multiply-imputed data on more than 7600 men and women of a British birth cohort study (National Child Development Study, 1958 British birth cohort) were used. Cardiovascular risk factors at age 44/45 years included body mass index, waist:hip ratio, blood pressure (systolic and diastolic), cholesterol (total, low and highdensity lipoprotein), triglycerides, glycated haemoglobin, C reactive protein, von Willebrand factor and fibrinogen. Age at first birth was categorised as ,20 years, 20-24 years, 25-29 years, 30-34 years or ,34 years. Results Being younger than 20 years of age at time of first birth was associated with an adverse cardiovascular profile by mid-life. Conversely, older ...
Mitochondrial function of immune cells in septic shock: A prospective observational cohort study. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Multiply imputed data from three nationally representative British birth cohorts were used-the MRC National Survey of Health and Development (NSHD; 1946 birth cohort, n=3012), the National Child Development Study (NCDS; 1958 birth cohort, n=9614) and the British Cohort Study (BCS; 1970 birth cohort, n=8140). A typology of work-family life course types was developed using multi-channel sequence analysis, linking annual information on work, partnerships and parenthood from 16 to 42 years. Work-family life courses were related to BMI trajectories using multi-level growth models. Analyses adjusted for indicators of prior health, birthweight, child BMI, educational attainment and socioeconomic position across the life course, and were stratified by gender and cohort ...
To study the natural history of a disease, investigators at times resort to cross-sectional cohort studies, whereby participants are randomly sampled at a fixed point in time. Once their baseline information and disease history are recorded, these participants are followed until death, loss to follow-up or study termination. This design is attractive because it generally requires limited resources. The data it generates, however, suffer from various systematic biases. For example, individuals with longer lifetimes tend to be excessively sampled, and among observed cases, individuals with longer disease durations and more recent onsets are usually overrepresented. In this presentation, the analysis of data emerging from either a cross-sectional cohort study, or its related subdesign, the prevalent cohort study, is discussed. The latter arises when only diseased individuals may be recruited at sampling time. Novel methodologies for estimating important epidemiologic measures of disease risk, such ...
BACKGROUND: Cross-sectional studies have shown an association between the farming environment and a decreased risk of atopic sensitization, mainly related to contact with farm animals in the childhood. OBJECTIVE: Investigate the association of a farming environment, especially farm animal contact, during infancy, with atopic sensitization and allergic diseases at the age of 31. METHODS: In a prospective birth cohort study, 5509 subjects born in northern Finland in 1966 were followed up at the age of 31. Prenatal exposure to the farming environment was documented before or at birth. At age 31, information on health status and childhood exposure to pets was collected by a questionnaire and skin prick tests were performed. RESULTS: Being born to a family having farm animals decreased the risk of atopic sensitization [odds ratio (OR) 0.67; 95% confidence interval (CI) 0.56-0.80], atopic eczema ever (OR 0.77; 95% CI 0.66-0.91), doctor-diagnosed asthma ever (OR 0.74; 95% CI 0.55-1.00), allergic rhinitis at
In Chinese patients with diabetes, having hemoglobin A1c (HbA1c) levels that are too high or too low may be associated with a greater risk of cardiovascular disease and death, according to a research letter published Jan. 25 in the Journal of the American College of Cardiology.. In this population-based retrospective cohort study, Eric Yuk Fai Wan, MSc, CStat, of the University of Hong Kong, and colleagues examined 117,389 adult Chinese patients with type 2 diabetes without any history of cardiovascular disease. After a median follow-up of 54.5 to 58.5 months, a J-shaped curvilinear relationship was observed between HbA1c levels and cardiovascular disease incidence, all-cause mortality and other outcomes. An HbA1c range of ≥7.0 percent to ,7.5 percent had the lowest risk of new cardiovascular disease, coronary heart disease, stroke, heart failure, all-cause mortality and cardiovascular disease-related mortality. By comparison, an HbA1c ,6.5 percent or ≥8.0 percent was associated with a ...
In 1998, it was decided to build a single cohort, named the Swiss Mother and Child HIV Cohort Study (MoCHiV) and in 2003, MoCHiV was integrated in the
b,Objective,/b,,p,,/p, Self-reported general health and mental health are independent predictors of all-cause mortality. This study examines whether they are also independent predictors of incident cancer, coronary heart disease and psychiatric hospitalisation. ,b,Methods,/b,,p,,/p, We conducted a retrospective, population cohort study by linking the 19 625 Scottish adults who participated in the Scottish Health Surveys 1995-2003, to hospital admissions, cancer registration and death certificate records. We conducted Cox proportional hazard models adjusting for potential confounders including age, sex, socioeconomic status, alcohol, smoking status, body mass index, hypertension and diabetes. ,b,Results,/b,,p,,/p, Poor general health was reported by 1215 (6.2%) participants and was associated with cancer registrations (adjusted Hazard Ratio [HR] 1.30, 95% CI 1.10, 1.55), coronary heart disease events (adjusted HR 2.30, 95% CI 1.86, 2.84) and psychiatric hospitalisations (adjusted HR 2.42, 95% CI ...
Cam morphology is a strong risk factor for the development of hip pain and osteoarthritis. It is increasingly thought to develop in association with intense physical activity during youth; however, the aetiology remains uncertain. The study aim was to characterise the effect of physical activity on morphological hip development during adolescence.Cross-sectional study of individuals aged 9-18 years recruited from Southampton Football Club Academy (103 male) with an age-matched control population (52 males and 55 females). Assessments included questionnaires and 3 Tesla MRI of both hips. Alpha angle, epiphyseal extension and epiphyseal tilt were measured on radial images.Alpha angle and epiphyseal extension increased most rapidly between ages 12 and 14 years. Soft-tissue hypertrophy at the femoral head-neck junction preceded osseous cam morphology and was first evident at age 10 years. The greatest increase and highest absolute values of alpha angle and epiphyseal extension were colocalised at 1 oclock.
Cam morphology is a strong risk factor for the development of hip pain and osteoarthritis. It is increasingly thought to develop in association with intense physical activity during youth; however, the aetiology remains uncertain. The study aim was to characterise the effect of physical activity on morphological hip development during adolescence.Cross-sectional study of individuals aged 9-18 years recruited from Southampton Football Club Academy (103 male) with an age-matched control population (52 males and 55 females). Assessments included questionnaires and 3 Tesla MRI of both hips. Alpha angle, epiphyseal extension and epiphyseal tilt were measured on radial images.Alpha angle and epiphyseal extension increased most rapidly between ages 12 and 14 years. Soft-tissue hypertrophy at the femoral head-neck junction preceded osseous cam morphology and was first evident at age 10 years. The greatest increase and highest absolute values of alpha angle and epiphyseal extension were colocalised at 1 oclock.
The safety of calcium channel blockers in human pregnancy: a prospective, multicenter cohort study. MgS[O.sub.4] prevents left ventricular dysfunction in an animal model of preeclampsia