Results Among patients with MCI, greater severity of depressive symptoms was associated with greater global cognitive impairment, with a moderate effect size. A mediation analysis revealed that patients with MCI experiencing depressive symptoms may exhibit global cognitive impairment because their depressive symptoms were reducing their capacity for working memory, episodic memory and non-speed-based executive functions. A moderation analysis indicated that this effect was consistent across age, gender, years of education and APOE-e4 status for working memory and episodic memory, and was observed in patients with MCI older than 65 years for executive functions. In cognitively normal elderly adults and patients with AD, depressive symptoms were not associated with global cognitive impairment. ...
U.S., March 20 -- ClinicalTrials.gov registry received information related to the study (NCT03081429) titled A Prospective Cohort Study of Perioperative Covert Stroke and Postoperative Cognitive Dysfunction on March 10. Brief Summary: With the development of population aging, the incidence of covert stroke and cognitive dysfunction gradually increased. Currently, there is still lack of prospective cohort study with large sample size on the relationship between perioperative covert stroke and postoperative cognitive dysfunction. The investigators will perform a prospective cohort study. The aim of the study is to determine whether there is an association between perioperative covert stroke and postoperative cognitive dysfunction in elderly patients undergoing noncardiac surgery. Study Start Date: Study Type: Observational Condition: Anesthesia Postoperative Cognitive Dysfunction Covert Stroke Intervention: Not Provided Recruitment Status: Not yet recruiting Sponsor: Beijing Tiantan Hospital ...
Find Intellectual Disability Psychiatrists in Massachusetts, get help from a Massachusetts Intellectual Disability Psychiatrist in Massachusetts, get help with Cognitive Disability in Massachusetts.
Washington D.C. [USA], June 10 (ANI): U.S. researchers have found that radiation therapy (RT) used for treating patients with brain tumors can alter neural networks and cause long-term cognitive impairment.
Long-term cognitive impairment is a significant public health problem. In the October 3 issue of the New England Journal of Medicine, the BRAIN-ICU
Background: Identifying persons at risk for cognitive decline may aid in early detection of persons at risk of dementia and to select those that would benefit most from therapeutic or preventive measures for dementia. Objective: In this study we aimed to validate whether cognitive decline in the general population can be predicted with multivariate data using a previously proposed supervised classification method: Disease State Index (DSI). Methods: We included 2,542 participants, non-demented and without mild cognitive impairment at baseline, from the population-based Rotterdam Study (mean age 60.9 ± 9.1 years). Participants with significant global cognitive decline were defined as the 5% of participants with the largest cognitive decline per year. We trained DSI to predict occurrence of significant global cognitive decline using a large variety of baseline features, including magnetic resonance imaging (MRI) features, cardiovascular risk factors, APOE-ε4 allele carriership, gait features, ...
This study aimed to assess the relationship between renal impairment and cognitive decline. Of the 3769 patients, 396 (10%) had cognitive impairment at the outset. After the 2-year follow-up, 194 participants (6.2%) developed new cognitive impairment. Multiple logistic regression analysis showed that moderate-to-severe impaired renal function was associated with incident cognitive impairment after 2 years in a large cohort of elderly subjects ...
Objective: Mini-mental state examination, a nonspecific measure of global cognitive function, and the clock drawing test, a very concise and specific measure of cognitive function, are among the most widely used screening tests for cognitive dysfunction. The present research aimed to examine the correspondence between MMSE and CDT scores. Methods: A total of ...
Objective: To use functional MRI )fMRI) to investigate whether hippocampal activation during a memory task can predict cognitive decline in individuals with mild cognitive impairment (MCI). Methods: 25 older individuals with MCI performed a visual scene encoding task during fMRI scanning, and were followed clinically for at least 4 years after scanning. A hypothesis driven analysis of fMRI data was performed. First, fMRI data were analysed at the group level to identify the regions of the hippocampal formation that were engaged by this memory task. Parameter estimates of each subjects memory related hippocampal activation )% signal change) were extracted and were analysed with a linear regression model to determine whether hippocampal activation predicted the degree or rate of cognitive decline, as measured by change in Clinical Dementia Rating Sum-of-Boxes )CDR-SB). Results: Over 5.9 (1.2) years of follow-up after scanning, subjects varied widely in degree and rate of cognitive decline (change ...
2017 The Authors Introduction High levels of amyloid ß (Aß) are associated with cognitive decline in cognitively normal (CN) older adults. This study investigated the nature of cognitive decline in healthy individuals who did not progress to mild cognitive impairment or dementia. Method Cognition was measured over 72 months and compared between low (Aß-) and high (Aß+) CN older adults (n = 335) who did not progress to mild cognitive impairment or dementia and who remained free of severe or uncontrolled systemic illness. Results Compared to the Aß- group, the Aß+ group showed no cognitive impairment at baseline but showed substantial decline in verbal learning, episodic memory, and attention over 72 months. Discussion Moderate cognitive decline, particularly for learning and memory, was associated with Aß+ in CN older adults in the absence of clinical disease progression and uncontrolled or serious comorbid illness.. ...
Although cognitive disabilities and intellectual disabilities are related, the terms refer to different effects and conditions. In this lesson, we...
Postoperative cognitive dysfunction (POCD) is a common postoperative complication experienced by patients aged 65 years and older, and these older adults comprise more than one third of the surgical patients in the USA. Because not everyone with a history of exposure to surgery and anesthesia develops POCD, there are likely major biological risk factors involved. There are important gaps in our knowledge regarding whether genetic makeup, biological sex, or other Alzheimers disease risk factors predispose older adults to developing POCD. We set out to determine whether biological sex and Apolipoprotein E-ε4 (APOE4) carrier status increase the risk of developing POCD in older adults. We performed a cohort analysis of 1033 participants of prospective longitudinal aging studies. Participants underwent regular cognitive test batteries and we compared the annual rate of change over time in various cognitive measures in the women exposed to surgery and general anesthesia compared to the men exposed to
Postoperative cognitive dysfunction (POCD) is a decline in cognitive function (especially in memory and executive functions) that may last from a few days to a few weeks after surgery. In rare cases, this disorder may persist for several months after major surgery. POCD is distinct from emergence delirium. It occurs most commonly in older patients and those with pre-existing cognitive impairment. The causes of POCD are not understood. It does not appear to be caused by lack of oxygen or impaired blood flow to the brain and is equally likely under regional and general anesthesia. It may be mediated by the bodys inflammatory response to surgery. POCD is common after cardiac surgery, and recent studies have now verified that POCD also exists after major non-cardiac surgery, although at a lower incidence. The risk of POCD increases with age, and the type of surgery is also important because there is a very low incidence associated with minor surgery. POCD is common in adult patients of all ages at ...
Postoperative cognitive decline (POCD) affects up to 50% of non-cardiac surgical patients greater than or equal to 65 years of age.. This study will test the hypothesis that preoperative presence of brain beta-amyloid plaques in non-demented subjects increases postoperative cognitive decline (POCD) in elderly subjects scheduled for hip or knee replacement.. The investigators hypothesize that preoperative beta-amyloid plaques will predict postoperative cognitive decline. ...
TY - JOUR. T1 - Subjective cognitive complaints and objective cognitive impairment in parkinsons disease. AU - Hong, Jin Yong. AU - Lee, Yoonju. AU - Sunwoo, Mun Kyung. AU - Sohn, Young H.. AU - Lee, Phil Hyu. PY - 2018/1. Y1 - 2018/1. N2 - Background and Purpose Subjective cognitive complaints (SCCs) are very common in patients with Parkinsons disease (PD). However, the relationship between SCCs and objective cognitive impairment is still unclear. This study aimed to determine whether SCCs are correlated with objective cognitive performance in patients with PD. Methods Totals of 148 cognitively normal patients, 71 patients with mild cognitive impairment (MCI), and 31 demented patients were recruited consecutively from a movement-disor-ders clinic. Their SCCs and cognitive performances were evaluated using the Cognitive Complaints Interview (CCI) and a comprehensive neuropsychological battery. Results The CCI score increased with age, duration of PD, and depression score, and was inversely ...
Major surgeries, such as cardiac or orthopaedic procedures in particular, expose the patient to extensive trauma, blood loss, and tissue injury; all of these factors effectively modulate the immune system to ultimately trigger an inflammatory response. Postoperative cognitive dysfunction (POCD), the condition being characterized by impairment of short and long-term memory, is one of common complicates following surgery. Recently, our data have demonstrated that neuroinflammation and microglia activation in the hippocampus following surgery are associated with cognitive decline. The aim of this thesis is to investigate the inflammatory signaling pathways specifically involved with POCD, with a particular interest between systemic inflammation and local inflammation in the brain following surgery. The data presented in this thesis introduce the general concepts and the involvement of inflammation in the etiology of cognitive dysfunctions using a mouse model of POCD. Upon the identification of ...
Objective : Performance validity tests (PVTs) are essential in neuropsychological evaluations; however, it has been questioned how PVTs function in the context of cognitive impairment, and whether cognitive impairment alone is sufficient to cause PVT failure. Further, there is concern that some clinicians will disregard failed PVTs due to their perception that failures represent false-positive errors secondary to cognitive impairment. This study examined patterns associated with cognitively impaired versus noncredible performance across a battery of PVTs and neuropsychological tests. Additionally, the impact of VA service-connection and disability-seeking status on test validity was investigated. Method : A mixed-clinical sample of 103 veterans were administered six PVTs and neuropsychological tests. Performance was compared across three groups: valid-cognitively unimpaired, valid-cognitively impaired, and noncredible. Results : Significant PVT score differences and failure rates emerged across ...
TY - JOUR. T1 - Mesial temporal tau is related to worse cognitive performance and greater neocortical tau load in amyloid-β-negative cognitively normal individuals. AU - Groot, Colin. AU - Doré, Vincent. AU - Robertson, Joanne. AU - Burnham, Samantha C.. AU - Savage, Greg. AU - Ossenkoppele, Rik. AU - Rowe, Christopher C.. AU - Villemagne, Victor L.. N1 - Funding Information: C.C.R. reports speaker honoraria from GE Healthcare and Avid Radiopharmaceuticals, consulting fees from Avid Radiopharmaceuticals, AstraZeneca, and Piramal Imaging, and research grants from Avid Radiopharmaceuticals, GE Healthcare, and Piramal Imaging all outside the scope of the submitted work. V.L.V. reports speaker honoraria from GE Healthcare, Piramal Imaging, and Avid Radiopharmaceuticals, and consulting fees from Lundbeck, AbbVie, Shanghai Green Valley Co, IXICO, and Hoffmann La Roche, all outside the scope of the submitted work. C.G., V.D., J.R., S.B., G.S., and R.O. report no disclosures. Funding Information: ...
Free download the The Mini-Mental State Exam (MMSE) 1.0 iPhone & iPad app (★★½,522 downloads),The Mini-Mental State Exam (MMSE) is the most widely used cognitive test for dementia in US clinical pract
Improving psychological well-being and cognitive health is now listed as the priority on the healthy aging agenda. Depression and cognitive impairment are great challenges for the elderly population. There have been numerous studies on depression and cognitive impairment and dementia. However, the neural correlates of depression and cognitive impairment have not yet been elucidated. With the development of neuroscience and relevant technologies, studies on anatomical and functional neural networks, neurobiological mechanisms of mood and cognition in old age will provide more insight into the potential diagnosis, prevention and intervention in depression and cognitive impairment. For example, longitudinal neuroimaging studies depicting the trajectories of patterns of structural and functional brain networks of mild cognitive impairment may provide potential imaging markers for the onset of dementia.Population-based studies have addressed the potential interaction between mood and cognitive impairment in
In this prospective cohort study of black and white adults in the United States aged 45 and older, free of stroke and baseline cognitive impairment, mid-range to high Lifes Simple 7 scores at baseline were associated with lower incidence of clinically relevant cognitive impairment on a 3-test measure of verbal learning, memory, and fluency. Rather than a dose-response pattern across the range of Lifes Simple 7 scores, we observed that associations with ICI were the same for the highest tertile of Lifes Simple 7 score and the middle tertile, relative to the lowest tertile. This pattern suggests that even intermediate levels of CVH are preferable to low levels of CVH. This is an encouraging message for population health promotion, because intermediate CVH is a more realistic target than ideal CVH for many individuals.. The purpose of the Lifes Simple 7 metric is to summarize several modifiable factors into a single score to promote and measure individual- and population-level improvements in ...
Postoperative cognitive dysfunction is the deterioration of cognitive performance after anesthesia and surgery, and manifests as impairments in short-term memory, concentration, language comprehension, and social integration skills ...
ACE-R - Addenbrooke's Cognitive Examination Revised. Looking for abbreviations of ACE-R? It is Addenbrooke's Cognitive Examination Revised. Addenbrooke's Cognitive Examination Revised listed as ACE-R
...Postoperative cognitive dysfunction is the deterioration of cognitive ......,Aspartic,acid,in,the,hippocampus:,A,biomarker,for,postoperative,cognitive,dysfunction,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Presbycusis-related tinnitus and cognitive impairment are common in the elderly and generate a massive burden on family and society. Except for age, the study explored the gender differences in the prevalence of the three diseases. We found that women have an advantage in maintaining better cognitive and auditory functions. Recent studies suggest the complex links among the three diseases. Peripheral hearing loss can affect sound coding and neural plasticity, which will lead to cognitive impairment and tinnitus. The deficits of the central nervous system, especially central auditory structures, can, in turn, cause the presbycusis. The interaction among three diseases indicated that comprehensive assessment, intervention and treatment in consideration of hearing loss, tinnitus and cognitive impairment are important to decay aging.
Author(s): Simon, Tony J; Wu, Zhongle; Avants, Brian; Zhang, Hui; Gee, James C; Stebbins, Glenn T | Abstract: BACKGROUND:Chromosome 22q11.2 deletion syndrome is one of the most common genetic causes of cognitive impairment and developmental disability yet little is known about the neural bases of those challenges. Here we expand upon our previous neurocognitive studies by specifically investigating the hypothesis that changes in neural connectivity relate to cognitive impairment in children with the disorder. METHODS:Whole brain analyses of multiple measures computed from diffusion tensor image data acquired from the brains of children with the disorder and typically developing controls. We also correlated diffusion tensor data with performance on a visuospatial cognitive task that taps spatial attention. RESULTS:Analyses revealed four common clusters, in the parietal and frontal lobes, that showed complementary patterns of connectivity in children with the deletion and typical controls. We interpreted
Background The prevalence of dementia varies around the world, potentially contributed to by international differences in rates of age-related cognitive decline. Our primary goal was to investigate how rates of age-related decline in cognitive test performance varied among international cohort studies of cognitive aging. We also determined the extent to which sex, educational attainment, and apolipoprotein E ε4 allele (APOE*4) carrier status were associated with decline. Methods and findings We harmonized longitudinal data for 14 cohorts from 12 countries (Australia, Brazil, France, Greece, Hong Kong, Italy, Japan, Singapore, Spain, South Korea, United Kingdom, United States), for a total of 42,170 individuals aged 54-105 y (42% male), including 3.3% with dementia at baseline. The studies began between 1989 and 2011, with all but three ongoing, and each had 2-16 assessment waves (median = 3) and a follow-up duration of 2-15 y. We analyzed standardized Mini-Mental State Examination (MMSE) and memory
VP/VLBW individuals had significantly lower IQ scores than term-born individuals across all time points into adulthood. Approximately 1 in 4 VP/VLBW adults had a severe cognitive impairment and mean differences between VP/VLBW and term-born individuals in IQ scores were partly explained by those with cognitive impairment. IQ scores were consistently found to be more stable from childhood to adulthood in VP/VLBW than term-born individuals, yet this difference in stability disappeared when individuals with severe cognitive impairment in adulthood were excluded. Cognitive function in adulthood could be fairly well estimated from age 6 years in term-born children and already from age 20 months in VP/VLBW children. IQ scores were highly stable in VP/VLBW individuals who had cognitive impairment in adulthood.. VP/VLBW children are known to be at risk for neurodevelopmental problems, including cognitive impairment and higher risk of lower educational qualifications in young adulthood compared with ...
Type 2 diabetes mellitus (DM2) is associated with moderate cognitive impairment in verbal memory, mental flexibility, and information processing speed, while other cognitive functions remain relatively unaffected.1 Moreover, epidemiological studies have shown that DM2 patients have a twofold increased risk of developing either vascular dementia or Alzheimers disease.1,2 In the present study we examined whether mild cognitive impairment (MCI) and cognitive impairment, no dementia (CIND)-two concepts that are used to describe cognitive impairment in the transitional state between normal aging and early dementia-can be applied to the cognitive impairments encountered in a population based sample of DM2 patients. Recently, these concepts have attracted considerable attention, as individuals who meet the criteria for either MCI or CIND are known to have a substantially increased risk of developing dementia.3,4 MCI is defined as a memory deficit without impairments in other cognitive domains.3 ...
The incidence of severe forms of HIV-associated neuorcognitive disorders, or HAND, has declined significantly with the availability of combination antiretroviral drug therapy over the last 20 years.. But the prevalence of the milder form has remained stable and even slightly increased, affecting 50 to 60 per cent of people living with HIV and AIDS.. Screening tools have not been updated to reflect this change, said Dr. Sean B. Rourke, a neuropsychologist who heads the Neurobehavioural Research Unit at St. Michaels. We are still trying to use or adapt the older dementia screening tools to catch the milder form of HAND.. Dr. Rourke said that having effective screening tests to identify and differentiate the two different forms of HAND is important for treatment decision-making. The current standards of practice requires a detailed neuropsychological examination, which is time-consuming and not readily accessible.. Identifying that patients have a mild form of this condition is critical, ...
Given the aging population and the corresponding increase in the incidence of AD, information on the prognosis of AD will help practitioners and unpaid caregivers to better meet the needs of patients with AD.. This well designed, prospective study by Larson et al provides estimates of survival after initial diagnosis of AD. Estimated survival rates were longer than those reported by the Canadian Study of Health and Aging (3.2 y for men and 3.4 y for women).1 This difference may be attributed to the older sample in the Canadian Study of Health and Aging.. Length of survival after onset of AD may be quite different from length of survival after initial diagnosis. Identifying the precise onset of AD may be difficult because of the insidious nature of the disease, unpaid caregivers lack of awareness of changes in cognition and functional abilities, and the patients ability to compensate for impairments. Although diagnosis at the onset of disease may not alter the natural course of AD, it could ...
This page includes the following topics and synonyms: Mini-Mental State Exam, Mini-Mental Status Exam, Folstein Mini Mental Status Exam, Folstein MMSE, MMSE.
Studies have investigated the potential protective effects that diet may have on late-life depression incidence. This disorder can, however, affect the persons food intake, widely known as the reverse causality hypothesis of depression. To test this hypothesis, we compared mean nutrient intakes from three 24-h recalls during the year depression was detected (Geriatric Depression Scale ≥11 or antidepressant medication) with intakes from 1 year earlier among community-dwelling older adults (67-83 years) followed up annually in the 4-year Québec Longitudinal Study on Nutrition and Aging, who were free of depression and cognitive impairment at baseline. Participants (n 158, 64·4 % female) who became depressed and had data available for all follow-up years were matched by age group and sex with non-depressed participants. General linear mixed models were adjusted for percentage changes in physical activity, functional autonomy and stressful life events reported at the time of positive screening. ...
TY - JOUR. T1 - Retinal signs and 20-year cognitive decline in the Atherosclerosis Risk in Communities Study. AU - Deal, Jennifer A. AU - Richey Sharrett, A.. AU - Rawlings, Andreea M.. AU - Gottesman, Rebecca F. AU - Bandeen Roche, Karen J. AU - Albert, Marilyn. AU - Knopman, David. AU - Selvin, Elizabeth. AU - Wasserman, Bruce A. AU - Klein, Barbara. AU - Klein, Ronald. PY - 2018/3/27. Y1 - 2018/3/27. N2 - Objective To test the hypothesis that retinal vascular signs are associated with greater cognitive decline over 20 years in 12,317 men and women 50 to 73 years of age at baseline. Methods A composite cognitive score was created with 3 neuropsychological tests measured at 3 time points (1990-1992 to 2011-2013). Retinal signs were measured with fundus photography (1993-1995). Differences in cognitive change by retinal signs status were estimated with linear mixed models. Cognitive scores were imputed for living participants with incomplete cognitive testing. Results In multivariable-adjusted ...
Cross-sectional studies have indicated potential for positron emission tomography (PET) in imaging tau pathology in Alzheimers disease (AD); however, its prognostic utility remains unproven. In a longitudinal, multi-modal, prognostic study of cognitive decline, 20 patients with a clinical biomarker-based diagnosis in the AD spectrum (mild cognitive impairment or dementia and a positive amyloid-beta PET scan) were recruited from the Cognitive Clinic at Karolinska University Hospital. The participants underwent baseline neuropsychological assessment, PET imaging with [18F]THK5317, [11C]PIB and [18F]FDG, magnetic resonance imaging, and in a subgroup cerebrospinal fluid (CSF) sampling, with clinical follow-up after a median 48 months (interquartile range = 32:56). In total, 11 patients declined cognitively over time, while 9 remained cognitively stable. The accuracy of baseline [18F]THK5317 binding in temporal areas was excellent at predicting future cognitive decline (area under the receiver operating
Although the Seattle Longitudinal Study was designed to focus on cognitive changes in normal community-dwelling populations, it is inevitable that a prospective study of aging will eventually include in its successive follow-up cycles individuals who are beginning to show cognitive impairment and eventually may develop full-blown symptoms of dementia. This chapter reports some initial findings on the apolipoprotein E genetic marker of dementia as it relates to cognitive decline. Studies involving the neuropsychological assessment of a community-dwelling sample of older adults who have not previously been identified as suffering from cognitive impairment are described, along with the extension analyses that link the clinical measures with the psychometric battery for the study of normal aging. The chapter ends by analyzing studies that obtain postdicted estimates of earlier performance on the neuropsychological measures and speak to the possibility of early detection of risk for cognitive ...
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Results:. The mean age of the patients was 80 years; 68% of patients were women. Patients with six or more depressive symptoms had greater comorbid illness, functional impairment, and cognitive impairment at admission than patients with fewer depressive symptoms. Three-year mortality was higher in patients with six or more depressive symptoms (56% compared with 40%; hazard ratio, 1.56 [95% CI, 1.22 to 2.00]; P , 0.001). After adjustment for age, acute illness severity, comorbid illness, functional impairment, and cognitive impairment at the time of admission, patients with six or more depressive symptoms continued to have a higher mortality rate during the 3 years after admission (hazard ratio, 1.34 [CI, 1.03 to 1.73]). Although depressive symptoms contributed less to the mortality rate than did the total burden of comorbid medical illnesses, the excess mortality rate associated with depressive symptoms was greater than that conferred by one additional comorbid medical condition. ...
The classification of neurodegenerative disorders is based on the major component of the protein aggregates in the brain. The most common altered proteins associated with neurodegeneration are Hyperphosphorylated tau (HPt), beta amyloid (Aβ), alpha-synclein (αS) and transactive response DNA binding protein 43 (TDP43). In this study we assessed the incidence and the neuroanatomical distribution of proteins associated with neurodegeneration in the brain tissue of cognitively unimpaired subjects.. We demonstrated the early involvement of the Locus Coeruleus (LC) with HPt pathology in cognitively unimpaired mid aged subjects, a finding which supports the notion that LC is an initiation site of HPt pathology. This may suggest that development of clinical assessment techniques and radiological investigations reflecting early LC alterations may help in identifying subjects with early stages of neurodegeneration.. Furthermore, we studied a large cohort of cognitively unimpaired subjects with age at ...
welcome to the forum! i agree that one of the most frustrating parts of this dd is the problem with cognitive functions. i am currently working towards my bachelors in accounting and have definitely seen a decline in my ability to remember information. i have had to fall back on notes, notes, notes! i have notes in a couple of different places regarding when everything is due-in my planner, on my dry erase board, sticky notes on my computer-and that seems to really have helped me get things done on time. with regards to remembering important information, ive started relating information i need to know to other things..little tips or jingles or small poems or whatever that contains the information i need to remember and that has really helped, too. also, i take all of my classes online (which is very helpful!) and NEVER do homework or take a test if im in a lot of pain or overly tired or hungry. if youre taking in person classes then you obviously dont have the freedom of flexibility that ...
Retention of certain metabolites in the blood may contribute to cognitive impairment in patients with kidney failure, revealed a new study.
The vast majority of people in the United States have I.Q.s between 80 and 120, with an I.Q. of 100 considered average. To be diagnosed as having mental retardation, a person must have an I.Q. below 70-75, i.e. significantly below average. If a person scores below 70 on a properly administered and scored I.Q.. ...
Cognitive dysfunction can make a person feel hopeless, and they may turn to unfortunate sources in an effort to regain some control over their mental state. Commonly abused substances include alcohol, illegal narcotics and prescription drugs. Stimulants are a commonly abused drug for those who are dealing with cognitive issues that impair the sharpness of their mental processes. It is also possible to become addicted to legitimately prescribed medication that was initially aimed at treating a cognitive disorder. Individuals with cognitive impairment may become dependent on their medications and suffer withdrawal if they attempt to get off them without proper medical supervision.. If you or a loved one is addicted to medication for a cognitive disorder, help is available. Call our 24/7 hotline at 1-888-997-3147 for information on how you can get free of your addiction while managing the symptoms of your cognitive disorder.. ...
Multivariable repeated measures regression analysis identified three independent predictors of NPZ-3 worsening during follow-up ranging from 2 to 9 years (median 6): More years since entering the parent study (and thus more years on ART) and a time-varying CD4 count above 350 (versus below) protected against neurocognitive decline. Compared with a nadir CD4 count below 51, a nadir of 51 to 200 or above 200 tended to protect against decline, but those associations fell short of statistical significance. Among comorbidity risk factors, only a history of stroke independently raised the odds of declining NPZ-3 score. In a nonsignificant association, injection drug use tended to boost odds of worsening neurocognitive function ...
Results A total of 12,336 participants (baseline age 56.8 [5.7], 21% black, 56% women) were included. After adjusting for demographic variables, vascular risk factors, and comorbidities, each standard deviation (SD) increase in midlife inflammation composite score was associated with an additional 20-year decline of −0.035 SD (95% confidence interval: −0.062 to −0.007) on the cognitive composite score. We found a similar association between each SD increase in midlife CRP level and additional 20-year cognitive decline (−0.038 SD, 95% confidence interval: −0.057 to −0.019). Participants with a midlife inflammation composite score in the top quartile had a 7.8% steeper cognitive decline, compared to participants in the lowest quartile; CRP in the top quartile was associated with an 11.6% steeper cognitive decline. In cognitive domain-specific analyses, elevated midlife inflammatory markers were most consistently associated with declines in memory. Results were similar after adjusting ...
Effects of momentum-based dumbbell training on cognitive function in older adults with mild cognitive impairment: a pilot randomized controlled trial Jiaojiao Lü,1 Mingyun Sun,2,3 Leichao Liang,1 Yi Feng,1 Xiaoyu Pan,1 Yu Liu1 1Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai, 2Institue of Physical Education, Anqing Normal University, Anqing, 3Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, People’s Republic of China Purpose: The purpose of this study was to explore the effects of an innovative momentum-based dumbbell-training intervention on cognitive function in older adults with mild cognitive impairment (MCI).Subjects and methods: A total of 45 community-dwelling older adults with MCI were randomly assigned to either a dumbbell-training group (DTG; n=22) or a control group (CG; n=23). Participants in the DTG participated in exercise sessions three times weekly for 12 weeks. The primary
TY - JOUR. T1 - Cognitive impairment is a negative short-term and long-term prognostic factor in elderly patients with hip fracture. AU - Benedetti, M. G.. AU - Ginex, V.. AU - Mariani, E.. AU - Zati, A.. AU - Cotti, A.. AU - Pignotti, E.. AU - Clerici, F.. PY - 2015/12/1. Y1 - 2015/12/1. N2 - Background. Subjects with severe cognitive impairment (CI) have a high-risk of hip fractures with increased rate of adverse postoperative functional outcomes and mortality. Aim. To evaluate the impact of different degrees of CI on functional recovery and mortality after hip fracture. Design. Prospective observational study. Setting. Two orthopedic surgery units. Population. Two hundred twenty-eight consecutive patients after a hip surgery. Methods. Patients were assessed at baseline through the Short Portable Mental Status Questionnaire (SPMSQ), an instrument that allows to categorize subjects as follows: cognitively intact (SPMSQ≥8) or with mild (SPMSQ=6-7), moderate (SPMSQ=3-5) and severe CI ...
March 18, 2014 - Brain imaging using nuclear imaging radiotracers can detect early evidence of Alzheimers disease that may predict future cognitive decline among adults with mild or no cognitive impairment. This is according to a 36-month follow-up study led by Duke Medicine.. The national, multicenter study confirms earlier findings suggesting that identifying silent beta-amyloid plaque build-up in the brain could help guide care and treatment decisions for patients at risk for Alzheimers. The findings appeared online March 11, 2014, in Molecular Psychiatry, a Nature Publishing Group journal.. Our research found that healthy adults and those with mild memory loss who have a positive scan for these plaques have a much faster rate of decline on memory, language and reasoning over three years, said lead author P. Murali Doraiswamy, M.D., professor of psychiatry and director of the neurocognitive disorders program at Duke.. Alzheimers disease - which currently has no cure - afflicts an ...
Selkoe cautions that a commercial test for routine clinical care likely remains several years away. But for clinical trials that seek to evaluate preventive treatments for AD, such as the large-scale clinical trials led by co-author Reisa Sperling, MD, MMSc, director of the Center for Alzheimer Research and Treatment at the Brigham and Womens Hospital, NT1 levels could be measured before a participant enrolls in a trial, and potentially also as a longitudinal measure to assess treatment response. The test ultimately represents a far less costly and less invasive alternative to imaging and lumbar punctures ...
A study published in the journal Nature Neuroscience, from Nature publishing group, describes the identification of a novel molecular pathway that can constitute a therapeutic target for cognitive defects in Parkinsons disease.