OBJECTIVE: A previous pilot trial evaluating computer-based training for cognitive-behavioral therapy (CBT4CBT) in 77 heterogeneous substance users (alcohol, marijuana, cocaine, and opioids) demonstrated preliminary support for its efficacy in the context of a community-based outpatient clinic. The authors conducted a more definitive trial in a larger, more homogeneous sample. METHOD: In this randomized clinical trial, 101 cocaine-dependent individuals maintained on methadone were randomly assigned to standard methadone maintenance or methadone maintenance with weekly access to CBT4CBT, with seven modules delivered within an 8-week trial. RESULTS: Treatment retention and data availability were high and comparable across the treatment conditions. Participants assigned to the CBT4CBT condition were significantly more likely to attain 3 or more consecutive weeks of abstinence from cocaine (36% compared with 17%; p,0.05, odds ratio=0.36). The group assigned to CBT4CBT also had better outcomes on ...
Drug and Alcohol Findings Effectiveness Bank analysis titled: Randomized trial of continuing care enhancements for cocaine-dependent patients following initial engagement
Cocaine dependence remains a serious public health problem; however no clearly effective pharmacological treatments have been identified to date. The investigators hypothesize that identification of subgroups of cocaine-dependent patients will help to develop targeted and more effective treatments. The investigators have observed that 30-40% of cocaine-dependent patients who enter our medication trials achieve abstinence during the lead-in period (the two weeks prior to starting medication). Initial abstinence is strongly predictive of abstinence during the subsequent medication trial. The investigators have also observed that a low dopamine release in the striatum is associated with greater choice of cocaine in volunteers and failure of cocaine-dependent patients to respond to behavioral treatment. The investigators hypothesize that individuals who have difficulties in achieving abstinence have a deficit in dopaminergic functioning and correcting this deficit using dopaminergic medication LCE ...
(Maternal Cocaine Use and Birth Defects) Our data are from one of the first population-based studies in which trends for defects potentially caused by maternal cocaine use are examined; the results of our study show no significant change in the prevalence of multiple vascular disruption defects over time. We suspect that if cocaine is a teratogen, its teratogenicity is weak or is associated with a small subset of birth defects that are yet to be identified.
Learn more about Cocaine Use Disorder at TriStar Southern Hills DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Learn more about Cocaine Use Disorder at TriStar Centennial Parthenon Pavilion DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
2011 & "In Press". Bell, R.P., Foxe, J.J., Nierenberg, J., Hoptman, M.J., Garavan, H. White Matter Integrity as a Function of Abstinence Duration in Former Cocaine-Dependent Individuals. Drug and Alcohol Dependence, 2011, 114(2-3): 159-168.. Butler, J.S., Molholm, S., Fiebelkorn, I.C., Mercier, M.R., Schwartz, T.H., and Foxe, J.J. Common or redundant neural circuits for duration processing across audition and touch. Journal of Neuroscience, 2011, 31(9): 3400-3406.. Krakowski, A., Ross, L.A., Sehatpour, P., Snyder, A.C., Kelly, S.P., and Foxe, J.J. The neurophysiology of human biological motion processing: A high-density electrical mapping study. Neuroimage, 2011, 56(1): 373-383.. Brandwein, A.B., Foxe, J.J., Russo, N., Altschuler, T., Gomes, H., Molholm, S. The development of audiovisual multisensory integration across childhood and early adolescence: A high-density electrical mapping study. Cerebral Cortex, 2011, 21(5): 1042-1055. Foxe, J.J., Yeap, S., Kelly, S.P., Snyder, A.C., Thakore, J.H., ...
... has an educational background that includes a B.A. degree in biology, an M.S. degree in oceanography and limnology, an M.A. degree in counseling psychology, and a Ph.D. degree in behavioral neuroscience. He currently serves as a Clinical Instructor in psychology at the Department of Psychiatry, Harvard Medical School. He based at Massachusetts General Hospital, Charlestown, Mass. His addiction research has utilized repeated-measure assessments of sleep, attention, and executive function in cocaine-dependent individuals to study interactions of drug withdrawal, sleep, and cognition. His current research on the emotional regulatory function of sleep utilizes psychophysiological techniques in humans to investigate the effects of sleep on consolidation and generalization of extinction learning in experimental fear conditioning paradigms and exposure treatment for anxiety disorders. In the field of addiction, he is currently interested in research designed to produce extinction of
Researchers at the Icahn School of Medicine at Mount Sinai have identified an impairment in a brain region that might explain why it is difficult for persons with cocaine addiction to cease using the drug.. Using functional magnetic resonance imaging data, the research team found among cocaine-addicted individuals an impairment in the ventromedial prefrontal cortex, which governs impulse and self-control, possibly explaining why these individuals cannot form new associations for certain stimuli.. "Our study data suggests that it will be hard for longtime cocaine users to unlearn what once was a positive experience if this unlearning or new learning relies on this brain region to be effective," said Anna Konova, PhD, formerly with the Icahn School and now a postdoctoral fellow at New York Universitys Center for Neural Science.. The study compared 18 chronic cocaine users to 15 non-using controls on "extinction learning" activities resembling the exposure therapy often used to treat anxiety ...
The different clinical trajectories of cocaine-dependent men and women may be a consequence of distinct neurobiological substrates. Hypoperfusion of the orbitofrontal cortex (OFC) has previously been reported in individuals addicted to cocaine and ha
Changes in ovarian hormones across the menstrual cycle impact responses to cocaine in women. Studies have shown that cocaines effects are dampened during the luteal phase of the menstrual cycle, when estrogen and progesterone concentrations are high, relative to the other phases of the cycle, when concentrations of these hormones are relatively low. The purpose of this study is to determine whether progesterone reduces subjective and physiological responses to cocaine in cocaine dependent individuals. In addition, this study will help to advance the possibility of hormonal progesterone and pharmacologically related drugs as potential treatment components for cocaine abuse.. Participants will undergo two 4-day inpatient periods, totaling 8 days of treatment. For women, the inpatient periods will occur during two consecutive menstrual cycles; for men, they will occur during two consecutive months. On Day 1, participants will receive a first dose of either progesterone or placebo. On Day 2, ...
LOS ANGELES (KTLA) -- The L.A. County Coroners Office says Whitney Houstons death was an accidental drowning in the bathtub of her suite at the Beverly Hilton Hotel. But, in its preliminary
Tenderness is the language of the young children, of those who need the other. A childs love for mom and dad grows through their touch, their gaze, their voice, their tenderness. I like when I hear parents talk to their babies, adapting to the little child, sharing the same level of communication. This is tenderness: being on the same level as the other. God himself descended into Jesus to be on our level. This is the same path the Good Samaritan took. This is the path that Jesus himself took. He lowered himself, he lived his entire human existence practicing the real, concrete language of love. Yes, tenderness is the path of choice for the strongest, most courageous men and women. Tenderness is not weakness; it is fortitude. It is the path of solidarity, the path of humility. Please, allow me to say it loud and clear: the more powerful you are, the more your actions will have an impact on people, the more responsible you are to act humbly. If you dont, your power will ruin you, and you will ...
Cocaine. Crack cocaine continues to dominate the Nations illicit drug problem. The overall number of current cocaine users did not change significantly between 1995 and 1996 (1.45 million in 1995 and 1.75 million in 1996). This is down from a peak of 5.7 million in 1985. Nevertheless, there were still an estimated 652,000 Americans who used cocaine for the first time in 1995. Supplies remain abundant in nearly every city. Data indicate a leveling off in many urban areas: cocaine-related deaths were stable or up slightly in 9 of the 10 areas where such information was reported; emergency department (ED) mentions increased in only 4 of the 19 CEWG cities in the Drug Abuse Warning Network (DAWN);*** the percentage of treatment admissions for primary cocaine problems declined slightly or remained stable in 12 of the 14 areas where data were available; and prices of cocaine remained stable in most areas. Although demographic data continue to show most cocaine users as older, inner-city crack ...
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The sons of fathers who use cocaine may be less likely to become addicted to the drug themselves. - Emily Babay, Philadelphia Philly.com
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Pharmacologic treatment options for many substance use disorders (SUDs) are limited. This is especially true for cocaine use disorder and cannabis use disorder, for which there are no FDA-approved medications. FDA-approved medications for other SUDs often take the form of replacement or agonist therapies (eg, nicotine replacement therapy) that substitute the effects of the substance to aid in cessation. Other pharmacotherapies treat symptoms of withdrawal, reduce craving, or provide aversive counter-conditioning if the patient consumes the substance while on the medication (eg, disulfiram). The over-the-counter (OTC) antioxidant N-acetylcysteine (NAC) may be a potential treatment for SUDs. Although NAC is not approved by the FDA for treating SUDs, its proposed mechanism of action differs from that of current FDA-approved medications for SUDs. NACs potential for broad applicability, favorable adverse-effect profile, accessibility, and low cost make it an intriguing option for patients with ...
Chronic cocaine use alters the epigenetic profile of the FosB gene in the hippocampus. These alterations are required for cocaine-dependent gene expression and cocaine environment associations. Modification of hippocampal FosB results in a condition critical for cocaine-related learning.... Read More... ...
Another name for Abuse Crack is Cocaine Abuse. Complications of cocaine abuse during pregnancy include: * Women who use cocaine during pregnancy give ...
Cocaine is a naturally occurring alkaloid found within the leaves of a shrub, Erythroxylon coca. The earliest reported use of cocaine dates back to times when the ancient inhabitants of Peru used the leaves for religious ceremonies.
A study shows that chronic cocaine abuse speeds up the process of brain aging. The research revealed that age related loss of grey matter inside the human brain is increased in those who are addicted to cocaine in comparison to healthy people.For the research, the investigators scanned the brains of 120 individuals ...Read More... ...
Anton, R.F., Litten, R.Z., Falk, D.E., Palumbo, J.M., Bartus, R.T., Robinson, R.L., Kranzler, H.R., Kosten, T.R., Meyer, R.E., OBrien, C.P., Mann, K., Meulien, D. : The Alcohol Clinical Trials Initiative (ACTIVE): purpose and goals for assessing important and salient issues for medications development in alcohol use disorders. Drug Alcohol Depend 37(2): 402-411, 2012 Notes: PMCID: PC3242301 ...
Ironically, the explosion of basic-science knowledge about ASD and possible drug treatments is emerging at a time when major pharmaceutical companies are canceling drug-development programs for ASD and other mental disorders, citing costs, difficulties and the recent failures of what were deemed good prospects. Many National Institutes of Health officials, research scientists and affected families are fearful that progress in medication development will slow in the face of the industrys retreat from neuroscience drug development ...
When a person uses cocaine, he may become so enamored of the intoxicating effects of cocaine use that he may not even want to know about the damaging effects of the drug. But that would be a serious mistake.
Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Selective inhibition of cocaine-seeking behavior by a partial dopamine D(sub3) receptor agonist
BACKGROUND: Preclinical evidence indicates that exposure to cocaine influences the activity of the serotonin transporter (5-HTT) as well as several 5-HT receptor subtypes. However, little is known about the relationship between the 5-HTT and 5-HT receptors following cocaine exposure in humans. OBJECTIVE: We examined the relationship between platelet 5-HTT, a presynaptic 5-HT measure, and prolactin (PRL) response to meta-chlorophenylpiperazine (m-CPP), a postsynaptic 5-HT receptor agonist in cocaine dependent individuals. METHODS: Platelet [3H] paroxetine binding sites were assayed and the m-CPP challenge test was performed in 35 African American cocaine dependent individuals and 33 controls. Clinical measures included assessments of drug use severity and depression. RESULTS: Cocaine subjects showed reduced Bmax of [3H] paroxetine (t=4.67, ...
Nicotine sensitizes the mouse brain to the addictive effects of cocaine, according to recent NIDA-supported research. The results accord with the hypothesis that a persons initial use of an addictive substance physiologically sensitizes his or her brain to the rewarding and addictive effects of other substances. If the findings carry over to people, then preventing youths from smoking might reduce their vulnerability to cocaine abuse and addiction, and cocaine-dependent individuals might ease their path to recovery by quitting smoking. ...
Nicotine sensitizes the mouse brain to the addictive effects of cocaine, according to recent NIDA-supported research. The results accord with the hypothesis that a persons initial use of an addictive substance physiologically sensitizes his or her brain to the rewarding and addictive effects of other substances. If the findings carry over to people, then preventing youths from smoking might reduce their vulnerability to cocaine abuse and addiction, and cocaine-dependent individuals might ease their path to recovery by quitting smoking. ...
A cocaine vaccine has the following potential advantages over existing drug treatments for cocaine dependence: it blocks cocaine from entering the brain; it may have fewer side effects than drugs that act on the brain, and it may produce better patient compliance and treatment outcome than existing oral drugs.. If a cocaine vaccine proves effective in human clinical trials, it will be ethically justifiable to use it to treat cocaine dependent patients who have given free and informed consent to its use. The major ethical issues are ensuring that the treatment is safe and effective and that patients give free and informed consent to treatment. Protection of patient privacy and confidentiality is not likely to be a major concern. The major uncertainties about its safety arise because it will not completely block the effects of smoked or injected cocaine. Patients who attempt to subvert its effects by increasing their cocaine dose or using other stimulant drugs may put themselves at risk of adverse ...
Gooding, D.C., Ott, S.L., Roberts, S.A., & Erlenmeyer-Kimling, L. (2013). Thought disorder in mid-childhood as a predictor of adulthood diagnostic outcome: Findings from the New York High-Risk Project. Psychological Medicine, 43, 1003-1012.. Gooding, D.C., Tallent, K.A., & Matts, C.W. (2005). Clinical status of at-risk individuals five years later: Further validation of the psychometric high-risk strategy. Journal of Abnormal Psychology, 114, 170-175.. Gooding, D.C. & Pflum, M.J. (2013). The assessment of interpersonal pleasure: Introduction of the anticipatory and consummatory interpersonal pleasure scale (ACIPS) and preliminary findings. Psychiatry Research, doi:10.1016/j.psychres.2013.10.012.. Gooding, D.C., Gjini, K., Burroughs, S,, & Boutros, N.N. (2013). The association between psychosis-proneness and sensory gating in cocaine-dependent patients and healthy controls. Psychiatry Research, 210, 1092-1100.. Gooding, D.C. & Basso, M.A. (2008). The tell-tale tasks: A review of saccadic research ...
On February 14, 2011, two Swiss psychologists published two years research on cocaine addiction. They found that addicts who gambled were less likely to use cocaine or to relapse on cocaine. They think gambling may refocus the brains "reward center" from cocaine to gambling. They said that psychotherapy should be used along with gambling. More research is being done on long-term relapse rates (the number of people who eventually start using cocaine again).[33][34][better source needed] However, a more recent study looked at prize-based contingency management: a treatment method that offers addicts chances to win prizes if they do not use cocaine. This study found that prize-based contingency management helped cocaine addicts stay off cocaine, whether or not they had gambled recently. This suggests that it is the chance of a reward, not the gambling itself, that helps cocaine addicts stay off of cocaine.[35] ...
A second problem with the ADHD stimulant use issue is the misconception that people with "true" ADHD are less susceptible to the positive reinforcing effects of stimulants than people without ADHD. There are certainly subgroups of person with this diagnosis that do not like to take stimulants. They find that stimulants decrease their appetite, given them increased anxiety and insomnia, and in many cases leave them feeling more restricted, affectively blunted and less spontaneous. I find that these patients are generally selected out by the time they are adults. They had true ADHD diagnoses in middle school, did not like the stimulants, or in many cases their parents did not like the effect they were seeing and they were taken off of them. They may have developed significant coping strategies based on their dislike of stimulant effects. Like many adult psychiatric disorders there is no one uniform phenotype, and the phenotype of the person who was diagnosed either as a child or an adult and who ...
Cocaine has damaging effects on the brain, the heart and the mucous membrane of the nose. Significant symptoms of cocaine abuse are therefore paranoia, heart attacks and perforation of the nasal septum. The physical and mental effects of cocaine use are equally severe. The body and mind of a cocaine addict are both at risk.. Cocaine abuse and cocaine addiction cannot easily be distinguished because there may be no withdrawal symptoms. Similarly, users of crack cannot easily be distinguished from crack addicts. The boundary between drug use and drug abuse is not clear-cut and there may be no precise addiction symptoms.. The medical features and physical withdrawal characteristics of cocaine addiction are not as precise as they are in alcoholism or in addiction to some other drugs, such as heroin. Therefore the medical treatment of cocaine and crack abuse differs from that of other drugs.. Blood tests or urine tests would not distinguish between cocaine and crack but can show what other drugs have ...
Background Homologous cocaine self-administration procedures in laboratory animals and humans may facilitate translational research for medications development to treat cocaine dependence. This study, therefore, sought to establish choice between cocaine and an alternative reinforcer in rhesus monkeys responding under a procedure back-translated from previous human studies and homologous to a human laboratory procedure described in a companion paper. Methods Four rhesus monkeys with chronic indwelling intravenous catheters had access to cocaine injections (0, 0.043, 0.14, or 0.43 mg/kg/injection) and food (0, 1, 3, or 10 1 g banana-flavored food pellets). During daily 5 h sessions, a single cocaine dose and a single food-reinforcer magnitude were available in 10 30-min trials. During the initial
The state medical examiners office ruled Tuesday that the death of a Trinity student in November was accidental and caused by a rare stomach disorder that was exasperated by cocaine use.
1] M. Gossop, V. Manning, and G. Ridge, "Concurrent use of alcohol and cocaine: differences in patterns of use and problems among users of crack cocaine and cocaine powder," Alcohol Alcohol., vol. 41, pp. 121-125, 2006.. [2] H. R. Sumnall, G. F. Wagstaff, and J. C. Cole, "Self-reported psychopathology in polydrug users," J. Psychopharmacol., vol. 18, pp. 75-82, 2004.. [3] M. Graziani, P. Nencini, and R. Nisticò, "Genders and the concurrent use of cocaine and alcohol: Pharmacological aspects," Pharmacol. Res., vol. 87, pp. 60-70, 2014.. [4] L. J. Bierut, J. R. Strickland, J. R. Thompson, S. E. Afful, and L. B. Cottler, "Drug use and dependence in cocaine dependent subjects, community-based individuals, and their siblings," Drug Alcohol Depend., vol. 95, pp. 14-22, 2008.. [5] T. Apantaku-Olajide, C. D. Darker, and B. P. Smyth, "Onset of cocaine use: Associated alcohol intoxication and psychosocial characteristics among adolescents in substance abuse treatment," J. Addict. Med., vol. 7, pp. ...
Cocaine addiction is a serious issue. It affects all people and social classes. Cocaine addiction can cause death, imprisonment, and misery. It destroys lives and families. Dont let cocaine addiction ruin your life; get effective cocaine addiction treatment today!
Back. Brain and Cocaine. Techniques of positron emission tomography (PET) have shown in human cocaine abusers some of the ways by which cocaine produces its pleasurable effects as they are occurring. Researchers suggest that cocaine works in large part by occupying or blocking dopamine transporter (DAT) sites, thereby preventing reuptake of dopamine by the brain cells that release it, which then allows higher concentrations of dopamine to remain available in the brain longer than normal. It is this abnormally long presence of dopamine in the brain that is believed to cause the high and other effects associated with cocaine use.. Comparing the functioning of the dopamine system in the brains of chronic cocaine users with that in non-users, the researchers found that, compared to the non-users, the cocaine-dependent group showed reduced dopamine responses to the drug in the striatum, a region of the brain linked to motivation control and reward. At the same time, they found an abnormal increase in ...
Prenatal cocaine exposure (PCE), theorized in the 1970s, occurs when a pregnant woman uses cocaine and thereby exposes her fetus to the drug. "Crack baby" was a term coined to describe children who were exposed to crack (freebase cocaine in smokable form) as fetuses; the concept of the crack baby emerged in the US during the 1980s and 1990s in the midst of a crack epidemic. Other terms are "cocaine baby" and "crack kid". Early studies reported that people who had been exposed to crack in utero would be severely emotionally, mentally, and physically disabled; this belief became common in the scientific and lay communities. Fears were widespread that a generation of crack babies were going to put severe strain on society and social services as they grew up. Later studies failed to substantiate the findings of earlier ones that PCE has severe disabling consequences; these earlier studies had been methodologically flawed (e.g. with small sample sizes and confounding factors). Scientists have come to ...
Because DSM-IV cocaine dependence (CD) is heterogeneous, it is not an optimal phenotype to identify genetic variation contributing to risk for cocaine use and related behaviors (CRBs). We used a cluster analytic method to differentiate homogeneous, highly heritable subtypes of CRBs and to compare their utility with that of the DSM-IV CD as traits for genetic association analysis. Clinical features of CRBs and co-occurring disorders were obtained via a poly-diagnostic interview administered to 9,965 participants in genetic studies of substance dependence. A subsample of subjects (N = 3,443) were genotyped for 1,350 single nucleotide polymorphisms (SNPs) selected from 130 candidate genes related to addiction. Cluster analysis of clinical features of the sample yielded five subgroups, two of which were characterized by heavy cocaine use and high heritability: a heavy cocaine use, infrequent intravenous injection group and an early-onset, heavy cocaine use, high comorbidity group. The utility of ...
Cocaine addiction is a serious issue. It affects all people and social classes. Cocaine addiction can cause death, imprisonment, and misery. It destroys lives and families. Dont let cocaine addiction ruin your life; get effective cocaine addiction treatment today!
Cocaine abuse has become the most abused major stimulant in the USA and statistics show that emergency room visits for it are increasing. Cocaine abuse has been around for as long as anyone can remember.. Derived from the "innocent" cocoa plant, it is considered the "champagne" of drugs, one of its street names. There is an array of street names describing the different uses.. There are various ways that an addict will use this drug, amongst them being snorting, smoking one of the derivatives known as crack or rock. Historically, cocaine was known as the rich mans drug. This is changing rapidly as teenagers have found a new sensation in mixing it with marijuana.. The highly addictive nature of cocaine makes it an extremely dangerous drug and many a user will tell you that theyre not addicted. This is so far from the truth to be ridiculous. If cocaine abuse isnt a problem to the addict, how come they are still using it?. No-one would willingly remain addicted. The penalties are extreme. ...
Cocaine Addiction Centers in Cedar Rapids, IA. Find phone numbers, addresses and information about Cocaine Addiction Centers in Cedar Rapids.
TY - JOUR. T1 - Divergent effects of cocaine on cytokine production by lymphocytes and monocyte/macrophages. T2 - HIV-1 enhancement by cocaine within the blood-brain barrier. AU - Fiala, A. M.. AU - Gan, X. H.. AU - Newton, T.. AU - Chiappelli, F.. AU - Shapshak, P.. AU - Kermani, V.. AU - Kung, M. A.. AU - Diagne, A.. AU - Martinez, O.. AU - Way, D.. AU - Weinand, M.. AU - Witte, M.. AU - Graves, M.. PY - 1996/10/2. Y1 - 1996/10/2. N2 - Cocaine-related immunosuppression is assumed to have serious consequences, but its evaluation in drug-addicted subjects is lacking. In this study performed with materials from addicted subjects receiving intravenous cocaine and normal control subjects, acute cocaine effects on cytokine production in vivo and in mononuclear cells in vitro were determined. Acute intravenous cocaine administration resulted in (a) increased white blood cell and lymphocyte courts, (b) decreased tumor necrosis factor-α (TNF-α) and interleukin (IL)-10 serum levels; (c) depressed ...
Crack cocaine is a powerful stimulant that often causes hallucinations, erratic behavior and significant urges to repeat use. Crack addiction is a difficult habit to kick.
Another name for Addicted to Cocaine is Cocaine Abuse. Facts about cocaine abuse: * At least 1.5 million Americans use cocaine. * Cocaine use is most ...
Toronto Mayor Rob Fords confessed criminal conduct including smoking crack cocaine should be front and centre in mayoral debates.
In this cross-sectional study, the researchers sought to classify a sample of HIV-positive African-American crack cocaine smokers into homogenous HIV drug ...