Fukuyama congenital muscular dystrophy is an inherited condition that predominantly affects the muscles, brain, and eyes. Congenital muscular dystrophies are a group of genetic conditions that cause muscle weakness and wasting (atrophy) beginning very early in life.. Fukuyama congenital muscular dystrophy affects the skeletal muscles, which are muscles the body uses for movement. The first signs of the disorder appear in early infancy and include a weak cry, poor feeding, and weak muscle tone (hypotonia). Weakness of the facial muscles often leads to a distinctive facial appearance including droopy eyelids (ptosis) and an open mouth. In childhood, muscle weakness and joint deformities (contractures) restrict movement and interfere with the development of motor skills such as sitting, standing, and walking.. Fukuyama congenital muscular dystrophy also impairs brain development. People with this condition have a brain abnormality called cobblestone lissencephaly, in which the surface of the brain ...

Bilateral frontoparietal polymicrogyria (BFPP) is a genetic disorder with autosomal recessive inheritance that causes a cortical malformation. Our brain has folds in the cortex to increase surface area called gyri and patients with polymicrogyri have an increase number of folds and smaller folds than usual. Polymicrogyria is defined as a cerebral malformation of cortical development in which the normal gyral pattern of the surface of the brain is replaced by an excessive number of small, fused gyri separated by shallow sulci and abnormal cortical lamination. From ongoing research, mutation in GPR56, a member of the adhesion G protein-coupled receptor (GPCR) family, results in BFPP. These mutations are located in different regions of the protein without any evidence of a relationship between the position of the mutation and phenotypic severity. It is also found that GPR56 plays a role in cortical pattering. The GPR56 is grouped in the B family of GPCRs. This GPCR group have long N termini ...

Lissencephaly due to TUBA1A Mutation (Lissencephaly Type 3): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis.

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Define lissencephaly: the condition of having a smooth appearance on the surface of the brain; specifically : an abnormality of brain development…

We have embryonic cells in our eyes, but theyre not embryonic stem or pluripotent cells. Theyre restricted to making a few cell types, Dr. Temple said as she sketched cells, something that developmental biology lends itself to and that she does when talking about her work.. The researchers obtained human RPEs from eye banks that harvest corneas and then discard whats left. In a body, RPE cells are quiescent, but in culture they divide like crazy, forming coatings of cobblestone-like cells festooned with RPE markers.. To show that an RPE cell could be a stem cell, the researchers gently removed one at a time and transferred it to its own dish, giving it space to divide. This would reveal the defining characteristic of a stem cell: the ability to self-renew, to copy itself. (If all a stem cell could do was turn into any cell type, as theyre often defined, the culture would soon poop out. I see this oversimplification in news releases and media reports on a near-daily basis.). Most of the ...

In the present study, we examined the consequences of FE65 and FE65L1 deficiencies on mammalian brain development in mice. Until now, our understanding of the function of the FE65 family in vivo was limited to its role at the C. elegans neuromuscular junction (Zambrano et al, 2002; Bimonte et al, 2004). We report that the FE65 and FE65L1 proteins are required for integrity of the pial basement membrane, neuronal positioning and the establishment of normal axonal projections during cortical development. Furthermore, the phenotypes of the FE65 and FE65L1 double knockout share remarkable similarities with that reported for mutant mice lacking FE65‐binding partners, the three members of the APP gene family, that is APP, APLP1 and APLP2 (Herms et al, 2004), and the Ena/Vasp protein family (Lanier et al, 1999).. Molecules implicated in neuronal migration such as those necessary for locomotion, nucleokinesis and adhesion of migrating neurons along radial glia contribute to cortical development (Marin ...

X-linked lissencephaly and double cortex are allelic human disorders mapping to Xq22.3-Xq23 associated with arrest of migrating cerebral cortical neurons. We identified a novel 10 kb brain-specific cDNA interrupted by a balanced translocation in an XLIS patient that encodes a novel 40 kDa predicte …

Thank you so much for Mrs. Rabbit! I love her. Shes got just the right amount of sweet Annie-that much wont make me sneeze! She and Elizabeth are hugging on the dinning room table ...

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Proud to Serve in Charleston So proud to be able to begin our first Joint Base Charleston project in December! After working at Creech, Fort Huachuca, Nellis and Davis-Monthan, we are excited to continue to build important projects for our military. Charleston, the hometown of owner Benden Parker, holds a dear place in our hearts. […]

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Free Shipping: We offer free postage on orders over £50.00 to the UK sent via Royal Mail.* *To qualify for free postage the order must be sent as one package. Therefore, all items must be in stock or you should be happy to wait until all items become available to ship so they can be sent as one package. Downloads and Gift Vouchers do not count towards free shipping. Please note that Pre-Orders do not count towards free shipping as their release dates are liable to fluctuate. Stock Status If your order contains items that have different estimated shipping dates (for example, available to pre-order, in stock, available to ship in 1-3 days) you will be given an option either to wait for everything to become available to ship in one package, or to ship each item as soon as it becomes available. Stock arrives at the office throughout the day so the stock status of items on the website can change several times a day. Important Note: all items that are not currently displaying as In Stock need ...

Endothelial cells plated on two-dimensional (2-D) substrata proliferate until they form a tightly apposed confluent monolayer of quiescent cells that display a typical cobblestone morphology. When added to proliferating cultures TGF beta-1 (transforming growth factor beta-1) inhibited cell growth and caused marked morphological changes, with the cells becoming enlarged and ragged. These effects were dose-dependent and reversible. TGF beta-1 also reduced the cloning efficiency and colony size of these cells, indicating that TGF beta-1 is cytotoxic and cytostatic for endothelial cells. By contrast, TGF beta-1 added to quiescent cobblestone cultures did not affect cell morphology or cell numbers. In the presence of 20% serum, the level of total protein synthesis per cell was significantly increased by TGF beta-1 in a dose-dependent manner when the cells were cultured on a 2-D substratum, regardless of whether the cells were proliferating or cobblestone quiescent. The level of plasminogen ...

From the corridors of Washington to the cobblestones of Paris, the coronavirus is roaring back and authorities are ramping up restrictions again. This time around, however, everyone is tired.

Here is when heaven turns to black and hell to white. An ethereal journey waits shall your decision to continue through the delights that are Virtus be valid. Be welcomed with open arms and warm embraces all around. The jovial souls who call this place home truly light the city ablaze, for without the radiating delight they provide, this would be just another mark on the travelers map. Exquisite waterfalls touched by saintly gods rush down in the backdrop of the white city and its immense peaks. The sun-bleached cobblestones are now well-worn with the infinite passage across their face, directing traffic to any number of quaint shops for whatever the heart desires. Or perhaps its not a shop you seek, but the sweet comforts of royalty leading from the core ...

Fresh salt breezes rolling over worn cobblestones. Fishermen unloading. A sea of color, sounds and activity. A true catch-to-consumption experience...

Cobblestone blocks have a great stackedstoneaesthetic. Each one-ton block features the appearance of six smaller blocks, making it a great look for projects that need a smaller-scale look.Upto 23 square feet (2 square meters) of non-repeating texture is available

Michelle W of WordPress HQ wants our eyes and lenses focused on the front for this weeks Weekly Photo Challenge: FORWARD. Pardon me for being FORWARD, but would you like to get footloose and explore some of the alleyways, byways and waterways that Ive encountered during my meanderings along the cobblestone to somewhere? Great. Just double-knot your…

I mentioned in another thread that I dont think a component used by a pro in a race implies that the component is good enough. If say a carbon frame is used in Paris Roubaix, Im pretty sure that thats a brand new frame and it probably wont be used again after the race. Cracks can develop during the course of the race, but not grow over that relatively short period of time and so nothing goes wrong on TV. For stage races, the mechanics most likely thoroughly check each bike and replace where they suspect there might be issues. Contrast with normal consumers who usually ride a frame for at least a couple of years: theyre going to continue using that frame after riding on the same cobblestones, giving any cracks formed the chance to develop and result in the component ultimately becoming unusable ...

Realizing how fragile life is is scary. That fragility doesnt seem quite real until something tips you towards the ground as youre hurrying along minding your own business, and you feel the slow motion seconds ticking by as you speed towards the cobblestones, suddenly very aware that you are made of the finest crystal and…

As the tram moves up the steep tracks of Artilleria Hill, I catch glimpses of Valparaiso and its port below. The ride is a mere five minutes, and at the top we emerge on a promenade lifted from the late 19th century. It has cobblestones, blossoming trees and a cast-iron railing worthy of Queen Victoria with all its flourishes.

Clockwise from top: 1. Performance Piqué, the perfect fabric for workout tops and tees! The print pictured here is Cobblestone Trellis Pink by Lulabelle. 2. The sweets in Kociaras lovely Pin Up Fitness print remind us why were sweating it out! 3. Kitty-themed team spirit is a breeze when you make your own running outfits-the Colleterie shows you the process of designing a winning ensemble. 4. This custom yoga bag is durable and super-functional with an adjustable strap! 5. Whip up several of these VNA tops by Fehr Trade to add a little elegance to your workout attire-the pattern is based on a 1930s Vionnet evening gown! 6. These versatile City Gym Shorts are perfect for all ages, and mixing and matching fabric prints gives you infinite style possibilities!. Please do share your tips for staying motivated to work out in the comments below, and keep on movin!. Becca. ...

The Akamasoa project, which is funded by donors around the world and recognized by the Madagascar government, says it has built some 4,000 homes in more than 20 villages serving some 25,000 people since its foundation in 1989. About 700 people work in the rock quarry, using simple mallets to chop chunks of granite into cobblestones or pebbles, while others work as carpenters or attend training classes. It says 14,000 children have passed through its schools ...

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Welcome to Cobblestone, Kendallvilles premier public championship golf course and event center, offering golf situated on 240 beautiful acres of rolling terrain with challenging features throughout the course. Newly introduced in 2016, a set of 5 tee boxes - sure to be enjoyable for golfers of all skill levels. A highly rated Northeast Indiana public golf course, Cobblestone will give you the quality experience you come to expect at top rated public golf courses. You will be able to enjoy playing all day, with our everyday, all day specials. Fine tune your game with access to our conveniently located, driving range, chipping green, and putting green to tune up before your next round. An indoor golf simulator which has over 20 world-class courses can be played in the winter making the golf experience at Cobblestone year round. Our Pro Shop can provide all of the necessary accessories and refreshments to make your day of golf enjoyable here at Cobblestone.. Our event room is available and ...

Looking for online definition of lissencephaly in the Medical Dictionary? lissencephaly explanation free. What is lissencephaly? Meaning of lissencephaly medical term. What does lissencephaly mean?

NIH Rare Diseases : 50 the following summary is from orphanet, a european reference portal for information on rare diseases and orphan drugs.orpha number: 48471disease definitionthe term lissencephaly covers a group of rare malformations sharing the common feature of anomalies in the appearance of brain convolutions (characterised by simplification or absence of folding) associated with abnormal organisation of the cortical layers as a result of neuronal migration defects during embryogenesis.epidemiologythe incidence of all forms of type i lissencephaly is around 1 in 100,000 births.clinical descriptionchildren with lissencephaly have feeding and swallowing problems, muscle tone anomalies (early hypotonia and subsequently limb hypertonia), seizures (in particular, infantile spasms) and severe psychomotor retardation. multiple forms of lissencephaly have been described and their current classification is based on the associated malformations and underlying aetiology. two large groups can be ...

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Lissencephaly represents a developmental disorder resulting from abnormal neuronal migration. A wide spectrum of cerebral pathology can be seen in lissencephaly - from pachygyria and agyria (reduction and absence of cerebral convolutions, respectively) to subcortical band heterotopia where cerebral convolutions appear normal.

When we started working on the landscaping for our cottage in the woods, we were unsure of how to handle the hill that joined the side of the house with our country lane. Initially I really wanted some stairs leading up to the front door, otherwise we would always have to enter the house through the garage/basement… unless we walked all the way around the hill & up to the front door.. After looking at the size of the project, the price that it was surely going to cost, not to mention not knowing exactly how to go about accomplishing the project, I was afraid that we were going to have to settle for something less that what we really wanted. But… after going through lots of pictures, and discovering some new ideas to build a set of stairs ourselves, we finally had a new option!. You see, initially we tried to build the steps from stone that we gathered from around the property, but no matter what we did, we couldnt get them to lay even. Because we didnt want anyone to catch their toe & trip ...

When we started working on the landscaping for our cottage in the woods, we were unsure of how to handle the hill that joined the side of the house with our country lane. Initially I really wanted some stairs leading up to the front door, otherwise we would always have to enter the house through the garage/basement… unless we walked all the way around the hill & up to the front door.. After looking at the size of the project, the price that it was surely going to cost, not to mention not knowing exactly how to go about accomplishing the project, I was afraid that we were going to have to settle for something less that what we really wanted. But… after going through lots of pictures, and discovering some new ideas to build a set of stairs ourselves, we finally had a new option!. You see, initially we tried to build the steps from stone that we gathered from around the property, but no matter what we did, we couldnt get them to lay even. Because we didnt want anyone to catch their toe & trip ...

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Disclaimer: This article is very strongly opinionated. It may even offend some readers. It is not intended to do that. Read at your own risk. Im pretty steamed as I write this.. Theyre at it again. They are the Alberta government. Its flu season here in Alberta.. Last year we had a dismal 25% of the population take the flu shot. When the government saw that people were not initially lining up like obedient little children to get a flu shot, they put out the word that there was a very limited amount of vaccine available. People got panicky, and even though they had to pay out of pocket, often stood in line for hours to get the vaccination. In my not-so-humble opinion, it was a media frenzy created by bureaucracy, designed to frighten people. Scarcity is the number one marketing tactic. Anyone who has anything to sell will tell you that. The less there is of something the more everyone wants one, even if its cr*p. ...

From our preliminary observation, it appears that GE cavitations are an aspect of more complex conditions associated with severe cerebral structural derangement. The awareness of this rare developmental abnormality involving the GE region may have implications in better understanding of the complex malformations caused by defective cellular proliferation and migration, such as lissencephalies. The fact that the lesions were bilateral and symmetric with an inverted regular open C shape, an epithelium-like lining, regular margins, and no apparent signs of hemorrhage (including the 2 cases with T1-weighted images) suggests a malformative rather than necrotic-clastic origin. Familial recurrence in 2 cases and the presence of frontal band heterotopias in 1 case further support such a hypothesis. Although the data are not extensive enough to conclude a statistical significance, the available ADC values (cases 1 and 4), albeit showing a slight trend toward mild reduction (0.85 SD, 0.09 m2/s), ...

My lab is interested in several aspects of the development of the cerebral cortex. We are interested in how the different levels of organization in the cortex, from global to cellular and synaptic organization and from neural to vascular patterning, arise during normal development and how they may be affected in and contribute to brain neural and vascular diseases. To investigate how the exquisite layer organization of the cortex arises, we focus on the question of how the generation and migration of neurons and glia are regulated. We employ mouse genetics approaches and use tissue specific gene knockout technology to answer this question. Among the genes of interest to us is a gene involved in G protein coupled receptor (GPCR) signaling. We have found that mutation in this gene, ric-8a, which encodes a guanine nucleotide exchange factor (GEF) for heterotrimeric G proteins, results in cobblestone lissencephaly-like malformation in the cerebral cortex as well as lobule formation defects in the ...

At every summit the stakes got higher; they were learning about us and working out how to contain us, while we had ceased to evolve our tactics of spectacular summit blockades. Carnivals against capital are wonderful at delegitimizing global capital, but in Genoa they declared war against us. They would shoot us rather than ever let us get into the red zone. In any case, we had to stop and ask what would we do if we ever did get there? Preventing the G8 from meeting would never, alone, create the world we wanted. After Genoa, our direct action summit blockade tactics, which just two years before had shut down Seattle, could never happen again in the same way. The next step if we followed that path - really a cul de sac - which they want us to take was to declare all out war in a military battle we could never win. But as the blood dried on the cobblestones and white walls of the raided Diaz school, we realized that the struggle needed, once again, to be on our terms, not theirs. We needed to ...

Next step is to discard the things that are unlikely to be the source of the problem.. While Id really like the problem to be lack of beer, that is unlikely to be the cause.. Altering my stride by picking up my knees could very well do it.. Cobblestones can definitely cause injuries, but it wasnt very far, maybe a block or two.. I now have two reasonable suspects. If I changed both things tomorrow, and the problem went away, I would have no idea what fixed it. So the best course of action is to only change one thing at a time. This is important, so I will repeat it:. Only change one thing at a time!. I had this problem off and on for a year, and then it mysteriously went away. I tried different things, but I didnt keep a record or journal of what I did. This is another important thing to remember:. Keep a journal!. It doesnt have to be on the internet, like this one. It could be in a spiral notebook. Just keep track of the distance and or time you ran, and any information on how you felt. ...

Nantucket is one of the first settlements in America. Nantuckets original Native American inhabitants, the Wampanoag people, lived undisturbed until 1641 when the island was deeded by the British. The original deeds to the islands land were divided 31 ways, and many families who live on the island today are distant relatives to the islands Founding Fathers and so the island began to grow. It wasnt until the whaling boom in the 1700s, however, that Nantucket gained some exposure and the wealth now associated with the island. Now, with its cobblestone streets, quaint boutiques, pristine beaches, whaling museum, and year round festivals and attractions, Nantucket continues to be a favorite destination of people around the world ...

In reviewing Courtneys analysis in preparation for writing this post, it occurred to me that there is a fourth type of information. Imagine, for example, that my players have entered a room. It would be trivial of me to mention that the cobblestone floors have cracks in a few of the stones. I could mention to the players that the room smells so bad they can taste the pungent air on their tongues. Its not vital for me to do so, since the smell does not affect the game, but it does help the players to imagine their environment, which is fun, so why not. It is crucial that I tell the players there are two exits on the north wall, and that theres a large pile of stones in the corner.. 4. Hidden information.. I should probably not tell the players that theres a pile of gold under the stones. If they want to learn about that, then theyre going to need to do some work. Like maybe digging through the pile of stones.. There are two types of hidden information. The kind which can be modeled at the ...

Storied Italian women are said to sit on old stools set on cobblestone streets, rolling gnocchi off forks, pinching pasta into hankie shapes or cutting it into short tubes. Locally, pasta makers hand-cut fine, fresh pastas, too, and they are stunningly good. Our favorite local pasta dishes run the gamut, from understated elegance to decadent and over the top. Try them all and

Most explorers that head out for an overall outing end up wishing they stuffed less. As a youngster, the main event when I traversed Europe I wandered out from home with simply a half-full backpack, and shockingly then I consumed a huge bit of the outing wishing I wandered out from home with less. Mark Ryden Backpack. The more things you pass on with you the more trouble and weight you will experience the whole trip. Air terminals will end up being twice as bothering, motel extra rooms will be pretty much nothing, and you will quickly recognize pulling a gigantic and strong backpack over cobblestone roads tends to its own phenomenal kind of damnation. Expecting you need to benefit as much as possible from your excursion, pack light. What You Need to Bring: This is the thing that you need to pack regardless, for an uncertainly extended trip: One-week of articles of clothing appropriate to your goals environment. Whatever contraptions you need. Whatever chargers your contraptions need. A power ...

Ever since Saint Darwin returned with harvested seeds from an Egyptian bush that wouldnt burn, golem constables have worked alongside human and ghost inspectors. They patrol Englands cobblestone streets together, keeping them safe from the monsters the patron saint of scientists exposed to the world. But when inanimate golems are being trafficked by a shadowy group of businessmen dressed up in wicked smiles and sharp teeth, its up to the Paranormal Patrols newest created member - Constable Lump - to go undercover in the gaslit night and learn where his missing brethren have vanished to, without sacrificing his newfound life getting the answers ...

Back into Switzerland and time to drive the St Gotthard pass. There are 2 passes of Gotthard, the old pass (or known as Tremola Pass) made from uneven cobblestone in 1830 and the new pass which was paved in 1977. Unfortunately driving the old pass wasnt much fun and is quite a slow... ...

Welcome to the Annapolis Podcast. From 1649 to present times, every cobblestone of this seaport city has a story to tell. Please join Scott MacMullan for conversations with prominent Annapolitans to discuss these historic and contemporary stories. The Annapolis Podcast is produced and hosted by Scott MacMullan. Contact Scott with any questions or comments. www.macmullanlaw.com

Spring. It should have meant boat launches on the river, tulips opening in Richters Park, the brick townhouse facades and red cobblestones of Laum Street washed clean and smooth. The air should have been filled with voices and flowers and the far-off scent of rain.. But for the last three years, since the soldiers came, spring in the Reich had meant something else.. I saved you a place, Hermine said. She had been an acquaintance of mine before the revolution: now, when it was safest to surround oneself with patriots and zealots, she was my closest friend. Right below the scaffold. Theyre sure to see you there.. I swallowed past the lump in my throat and followed her though the crowd, gripping her hand when the press became too tight. In this crowd of red and white and gold, we could all-too-easily be separated.. We heard that you were raided, she said as we parted a group of tricolor-wielding schoolchildren. There was a sticky trace of gloating in her voice; she was reassured by the ...

Neil has posted here several times about the Northern Lights, and each time he does, I am reminded of the fact that I have never seen them. This bothers me. Seeing the Northern Lights, in fact photographing them, has long been a life list goal of mine, and the fact Ive never seen anything other than pictures bothers me. Well, pictures is what I have, so for now I have to stick to them. As you probably know, to see the Northern Lights, you have to go North. Easy enough, right. But where? Well, Canada is a good start. But another place, where you can get not just a wonderful full of the lights, but also have a wonderful travel experience, is Finland. Finland has long long been on my list of MUST-VISIT countries. No question about it. Ive wanted to walk the cobblestone roads of Helsinki and sip aquavit there (not to mention check out the lovely Finnish women) for much of my life. And as I say, now I have another reason to go. Here, see what I mean. Check out this series of amazing photos of the ...

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Traveling is all about fun and adventure: traipsing through lush jungles, floating in crystal clear springs, and wandering down historic cobblestone street

After way too much travail, a lot of trial and error, and a ridiculous amount of swatching (Really? For a dish cloth?!) it started to dawn on me that at a certain point I had swatched more for this dish cloth than for the Klaralund, Cobblestone and Drive-Thru COMBINED. So I decided to break out and go free style. Yes, its my first pattern. Later, Brompton. Step off, Marigold Socks. Bainbridge? Please. Theres a new kid in town. Im calling it The Perfect Dishcloth™. This very intricate pattern will one day be hailed as the greatest dish cloth in the history of the world. Now before you all crash the server trying to download the pattern à la the Fiddlehead Mitten incident, I forgot to write down the pattern before mailing it off, so youre on your own. ...

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What the heck does a minimalist fashion and lifestyle blog have to do with science? Thats what youll be wondering quite soon, which is completely understandable as it was the question that was repeatedly popping up over and over again while posing for the picture above in the lobby of one of the worlds largest PR firms for a supremely over-my-level-of-comprehension conference event for ViaCord. But as with most things judged based on ignorance with just a smidgin of self-absorption, my mind was blown that there was a whole industry I knew nothing about that was saving as many lives as stilettos were tripping up not so effortless fashionistas strolling on cobblestone streets. Is it that we all have our heads to far up our you know whats, or is it more than that? When I mused about my minimalist number (a number thats so much less embarrassing for people to proclaim than the other number, cough cough) I posed a question to you all: what would life loom like if we werent spending 70% of our ...

Leg Strength Power Walking in Portugal. Marta and Brock go for a long walk through the cobblestone walkways, hills, and stairs through Porto in Portugal, and...

By Asher Mendelson MD, Critical Care and Medical Biophysics ISPD 2018 Scientific Committee member, and chair, Basic Science Pre-course The PD community has always had an interesting relationship with glucose. As a trusted friend, this molecule underpins the essential.... read more ...

J:79871 Kitamura K, Yanazawa M, Sugiyama N, Miura H, Iizuka-Kogo A, Kusaka M, Omichi K, Suzuki R, Kato-Fukui Y, Kamiirisa K, Matsuo M, Kamijo S, Kasahara M, Yoshioka H, Ogata T, Fukuda T, Kondo I, Kato M, Dobyns WB, Yokoyama M, Morohashi K, Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans. Nat Genet. 2002 Nov;32(3):359-69 ...

Reiner, O.; Albrecht, U.; Gordon, M.; Chianese, K. A.; Wong, C.; Gal-Gerber, O.; Sapir, T.; Siracusa, L. D.; Buchberg, A. M.; Caskey, C. T. et al.; Eichele, G.: Lissencephaly gene (LIS1) expression in the CNS suggests a role in neuronal migration. The Journal of Neuroscience 15 (5), pp. 3730 - 3738 (1995 ...

This fundraiser is to help with the medical needs of Emma, she has Lissencephaly. . At 5 days old Emma was diagnosed with Lissencephay, which means smooth brain. She...