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SWISS-MODEL Repository entry for A0RTP4 (PDXT_CENSY), Pyridoxal 5-phosphate synthase subunit PdxT. Cenarchaeum symbiosum (strain A)

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To search for genetic clues to carbon and energy metabolism in Crenarchaeota, the researchers extracted C. symbiosum DNA from its host sponge and constructed a DNA library for sequencing the symbiont s genome. Hallam et al. then searched for representative genes linked to pathways associated with autotrophic carbon assimilation. They found many components of two pathways: the 3-hydroxypropionate cycle and the reductive tricarboxylic acid (citric acid) pathway (TCA). Both cycles involve a multistep series of chemical reactions that convert inorganic compounds in this case, carbon dioxide into organic carbon molecules. Though some components of the 3-hydroxypropionate cycle were missing in C. symbiosum, enough elements (including core proteins) were found to support a modified version of this pathway for carbon assimilation, using carbon dioxide ...

Terpenoids, also known as isoprenoids, are a large class of natural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the mevalonate pathway [MD:M00095] and the non-mevalonate pathway or the MEP/DOXP pathway [MD:M00096], for the terpenoid building blocks: isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). The action of prenyltransferases then generates higher-order building blocks: geranyl diphosphate (GPP), farsenyl diphosphate (FPP), and geranylgeranyl diphosphate (GGPP), which are the precursors of monoterpenoids (C10), sesquiterpenoids (C15), and diterpenoids (C20), respectively. Condensation of these building blocks gives rise to the precursors of sterols (C30) and carotenoids (C40). The MEP/DOXP pathway is absent in higher animals and fungi, but in green plants the MEP/DOXP and mevalonate pathways co-exist in separate cellular compartments. The MEP/DOXP pathway, operating in the plastids, is responsible for the formation of essential oil ...

Klasifikace archeí je i dnes neustále v pohybu. Současné systémy se snaží seskupovat organismy na základě jejich skutečné příbuznosti.[13] Velkou roli v systematice hrají sekvence genů pro ribozomální RNA, díky nimž lze příbuzenské vztahy odhalit.[14] Většina z těch nejznámějších archeí se dnes řadí do dvou kmenů, Euryarchaeota a Crenarchaeota. Přesto existují a jsou nadále objevovány i další kmeny, například druh Nanoarchaeum equitans, objevený v roce 2003, je klasifikován v samostatném kmeni Nanoarchaeota.[15] Pro hrstku neobvyklých termofilních archeí se zase zavedl kmen Korarchaeota.[16][17] Podobně byl pro druhy Nitrosopumilus maritimus, Cenarchaeum symbiosum a příbuzná mezofilní archaea zaveden kmen Thaumarchaeota.[18] Sekvenování archeálních genomů přineslo objevy dalších odlišných linií: V roce 2011 byl navržen nový kmen Aigararchaeota pro archeum Caldiarchaeum subterraneum, nalezené v geotermálních vodách v podzemním ...

This project is supported by the Canadian Institutes of Health Research, Canada Foundation for Innovation, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Canada, Genome Alberta, and Genome British Columbia, a not-for-profit organization that is leading Canadas national genomics strategy with $900 million in funding from the federal government ...

This project is supported by the Canadian Institutes of Health Research, Canada Foundation for Innovation, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Canada, Genome Alberta, and Genome British Columbia, a not-for-profit organization that is leading Canadas national genomics strategy with $900 million in funding from the federal government ...