Aim: To evaluate the combined and individual effects of thioxanthene containing antipsychotic and anti-platlet drug on Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) in rats.. Methods: This investigational study comprised of 100 albino rats of both sexual orientation, they were of 300 g to 350 g. We got ten groups, in which each group consisted of 10 rats (n=10).Ozagrel was used as anti-platelet and Zuclopenthixol was used as thioxanthene containing antipsychotic. Rats were treated with defined doses of Ozagrel and thioxanthene containing anti-psychotic (Zuclopenthixol) alone and in joined for three weeks (21 days). Blood test at 0, seventh, fourteenth and last day of study were taken. Mean Platelet Volume and Platelet Distribution Width were estimated from blood tests by using standard research center procedure. Results were accumulated and abridged by applying statistics. Correlation was framed between all days incentive to zero day values.. Results: Anti-psychotic drug and ...

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Schedule H is a class of prescription drugs in India appearing as an appendix to the Drugs and Cosmetics Rules, 1945 introduced in 1945. These are drugs which cannot be purchased over the counter without the prescription of a qualified doctor.The manufacture and sale of all drugs are covered under the Drugs and Cosmetics Act and Rules. It is revised at times based on the advice of the Drugs Technical Advisory Board, part of the Central Drugs Standard Control Organization[1] in the Ministry of Health and Family Welfare. The most recent schedule H (2006) lists 536 drugs from abacavir to zuclopenthixol.[2] However, enforcement of Schedule H laws in India is lax, compared to the more restrictive Schedule X, for which a mandatory documentation trail must be maintained.[3] ...

Detailed drug Information for thioxanthene Oral, Parenteral. Includes common brand names, drug descriptions, warnings, side effects and dosing information.

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This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any such depressants while you are using this medicine.. Do not take this medicine within an hour of taking antacids or medicine for diarrhea. Taking them too close together may make this medicine less effective.. Before having any kind of surgery, dental treatment, or emergency treatment, tell the medical doctor or dentist in charge that you are using this medicine. Taking thioxanthenes together with medicines that are used during surgery or dental or emergency treatments may increase the CNS depressant ...

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CD147 as receptor for pilus-mediated adhesion of meningococci to vascular endothelia. WO/2014/016152. Bourdoulous S, O. Join-Lambert, X. Nassif.. Use of phenothiazine derivative in the treatment of infectious purpura or purpura fulminans. WO/2018/083314. Bourdoulous S, Denis K, Le Guennec L.. Use of phenothiazine derivative in the treatment of infections caused by bacteria carrying type IV pili. WO/2019/008141. Bourdoulous S, Denis K, Le Guennec L.. Polypeptides and nucleic acids for treating ErbB2-dependent cancers. WO/2011/036211. Bourdoulous S, Djerbi-Bouillie R.. Development of a High Throughput Screening assay for the discovery of novel small molecules inhibitors of ErbB2/HER2 activity. FR1452246. Bourdoulous S, Faure C.. Zuclopenthixol hydrochloride derivatives and Ebselen derivatives as ErbB2 inhibitors. WO/2017/121755. Bourdoulous S, Faure C.. Diagnosis and/or prognosis of HER2-dependent cancer using moesin as a biomarker. EP17306465.0. Bourdoulous S, Faure C, Domingot A.. Diagnosis ...

Intense exercise in extreme heat can increase the risk of developing exertional heat stroke (EHS). EHS is 100% survivable with appropriate care, and it is imperative that health care professionals recognize predisposing factors that may increase susceptibility to EHS. Understanding risk factors for EHS will enable clinicians to create effective prevention strategies to improve exercise heat tolerance and mitigate EHS risk. This review addresses new perspectives on risk factors for EHS that focus on hydration, heat acclimatization, medical conditions, climate change and policies, medications, and strength and conditioning sessions. ...

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The policies youth football leagues should employ in prevention and response to exertional heat stroke. Includes the critical factors that have led to deaths and resulting litigation.

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patients with different neuroleptic medications 3.1. General features of schizophrenic patients Analysis of the saturation data was carried out using the non-linear least squares regression The mean ages of control, unmedicated, buty- analysis program, LIGAND. The results gathered rophenone-, phenothiazine-, benzisoxazole- and from this computer-assisted analysis were consis- thioxanthene-treated groups were 31.72.2, 24.8 tent with the presence of only one binding site on 2.3, 32.73.5, 33.73.6, 33.44.8 and 28.2 the platelets of control subjects and schizophrenic 2.9 years, respectively. The mean durations of patients. The present data were comparable to illness for the unmedicated, butyrophenone, our previous report ŽGovitrapong et al., phenothiazine, benzisoxazole and thioxanthene groups were 3.1 1.5, 9.92.8, 5.201.1, 9.9 ing to platelets of normal control subjects and 1.9 and 4.81.2 years, respectively. The mean durations of treatment on butyrophenones, patients are shown in Table ...

Ischemic (Infraction): In an ischemic infraction, blood supply to part of the brain is decreased, leading to dysfunction of the brain tissue in that area. There are four reasons why this might happen: Thrombosis (obstruction of a blood arteries by a blood clot forming locally) Embolism (obstruction due to an embolus from elsewhere in the body) Systemic hypo perfusion (general decrease in blood supply, e.g., in shock) Cortical Venous thrombosis

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Opipramol (OP), a clinically effective antidepressant with a tricyclic structure, is inactive as an inhibitor of biogenic amine uptake. [3H]Opipramol binds saturably to rat brain membranes (apparent KD = 4 nM, Bmax = 3 pmol/mg of protein). [3H]Opipramol binding can be differentiated into haloperidol-sensitive and -resistant components, with Ki values for haloperidol of 1 nM (Bmax = 1 pmol/mg of protein) and 350 nM (Bmax = 1.9 pmol/mg of protein), respectively. The drug specificity of the haloperidol-sensitive component is the same as that of sigma receptors labeled with (+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperdine. The haloperidol-resistant component does not correspond to any known neurotransmitter receptor or uptake recognition site. It displays high affinity for phenothiazines and related structures such as perphenazine, clopenthixol, and flupenthixol, whose potencies are comparable to that of opipramol. Because certain of these drugs are more potent at the haloperidol-resistant ...

View a complete table of contents at go.jblearning.com/casa.. For the past 11 years, Casa has worked toward his goal of preventing sudden death in sport at the Department of Kinesiology, Neag School of Education, University of Connecticut. He has published more than 110 peer-reviewed publications and presented more than 300 times on subjects related to exertional heat stroke, heat-related illnesses, hydration and preventing sudden death in sport. Casa has treated more than 130 cases of exertional heat stroke with zero fatalities. In October 2010, the Department of Kinesiology doctoral program at the University of Connecticut was ranked first in the country by the National Academy of Kinesiology.. Preventing Sudden Death in Sport and Physical Activity is available for $83.95 through the Jones & Bartlett website or by calling 800-832-0034. Members of the media interested in ordering a review copy of the book, scheduling an author interview or requesting an excerpt may contact Jody Sullivan, ...

On the evening of May 23rd 2015, a 23-year-old military trainee was transferred from the District General Hospital Mannar (DGHM) (situated in the dry zone of Sri Lanka) to the Teaching Hospital Anuradhapura (THA) for further management of coma and convulsions. The patient was participating in a 9 mile ruck marching marathon on that same morning. After about four hours, the patient fainted and had a seizure near the finishing line. His companions cooled his body with water and brought him to the DGHM at approximately 9 a.m. that morning.. After admission to DGHM, he regained partial consciousness in a few minutes and was hyperactive, irritable, confused and amnesic. His Glasgow Coma Scale (GCS) was 9, and his temperature was 39 °C, pulse was 119 beats per minute, and blood pressure was 115/57 mmHg. His arterial blood gas showed a partially-compensated metabolic acidosis [pH of 7.34 (7.35-7.45), PaCO2 of 27 (35-45) mmHg, HCO3 − of 14.6 (32-26) mEq/L], a blood glucose of 66 mg/dl, a serum ...

When the psychosis is believed to be triggered by the perceived stress of the treatment environment, it is advisable to transfer the patient as soon as possible to a less intimidating environment, for example from an intensive care unit to a general ward or from a general ward to the patients home, if adequate care is available there. Rapid tranquillisation may be needed if there is aggressive or disruptive behaviour. Chlorpromazine or haloperidol may be given in doses similar to those used in acute mania. If very rapid control of symptoms is required, diazepam can be given intravenously in a dose of 5-10 mg as Diazemuls. Intravenous therapy ensures near immediate delivery of the drug to its site of action and effectively avoids the danger of inadvertent accumulation of slowly absorbed intramuscular doses. Note also that intravenous doses can be repeated after only 5-10 minutes if no effect is observed.51 A recent review of rapid tranquillisation has recommended that the mainstay of ...

Email. Keeping hydrated and cool is just as important for Thoroughbreds as it is for humans on hot summer days. Heat and humidity, coupled with the stress of racing, can lead to heat stroke in horses. Heat stroke occurs when the brain becomes overheated and fails to function properly. Horses become disoriented and wobbly, sometimes kicking out at things that are not there. In extreme cases, a horse with severe heat stroke will fall to the ground. Dr. Neal Cleary, the chief examining veterinarian for the New York Racing Association, said he and his crew carefully monitor horses for signs of heat stroke after they race. Cleary said each NYRA track has water hoses located near the unsaddling areas and in the paddocks, and they are immediately put into use if a horse appears to be suffering from heat exhaustion. The cooling water from the hoses is also used as a preventive measure against the onset of heat stroke on steamy days. You need to cool the sutaneous veins in the neck, chest, and shoulder ...

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DESCRIPTION Benztropine mesylate is a synthetic compound containing structural features found in atropine and diphenhydramine. It is a crystalline white powder, very soluble in water. It is designated chemically as 3a-( Diphenylmethoxy)-1 aH,...

Characteristics and consequences of a heat stroke. Causes that can lead to this dangerous state and what to do if a person has suffered a heat stroke

Regardless of what the temperature or humidity is, always monitor your dog carefully for signs of fatigue or heat stroke. The sooner you notice these signs, the sooner you should stop any form of exercise, cool down your dog, and seek veterinary attention.

Talking Heat Stroke Warner - This jolly little fellow will tell you the temperature and humidity, as well as let you the chance of catching a cold or heat stroke. The Talking Heat Stroke Warner only speaks in Japanese but the LED will indicate the level of danger. Every 10 minutes this friendly chap will give you an update on t ...

My 14 yr old daughter collapsed about a month ago from heat. The hospital didnt take an accurate temp until I started asking much later. After 3 hrs of being in gown in cool ER, at least 1 liter of f...

So it was on this hot, summer day that the rest of my family decided to go off to do something together, and I was left alone at the house to take care of the dogs. I dont even remember where they were going, and I guess its unimportant anyway. The important part was -- and this was key -- my mother had deemed me grown-up enough to stay home by myself AND also decided I was responsible enough to take care of the dogs for a while by myself, too ...

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How much do 20 seconds cost per km? How to navigate if youre in an anthill? What to use to cure a heat stroke? And how to become the highlight of the program? 18 May 2014 ...

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Heats stroke (HS) is severe sunstroke caused by a rapid increase in ones core temperature in excess of 40 °C from exposure to a hot and humid environment. HS is accompanied by serious clinical syndromes that damage multiple organ systems. These syndromes include burning skin and impaired awareness, such as delirium, convulsions, and loss of consciousness.. Exertional heat stroke (EHS) is caused by a rapid increase in ones core temperature in excess of 40 °C from high intensity physical exercise in a hot and humid environment. EHS is accompanied by extremely serious clinical syndromes that damage multiple organs and multiple systems. Syndromes include impaired awareness, rhabdomyolysis, disseminated intravascular coagulation (DIC), acute liver damage, and acute renal damage. EHS is the most severe type of sunstroke and is characterized by acute onset and rapid progression The case fatality rate can reach more than 50 % if effective treatment is not received in a timely manner. EHS is commonly ...

Deaths are considered to be rare in sport, but detailed information and specific fatality rates for different sport settings are limited owing to a paucity of data. Most research originates in the USA,1 2 and it has identified sudden cardiac arrest, traumatic injuries to the head/neck, exertional heat stroke, hyponatremia and asthma2 as the leading causes. Put simply, in sport, death can result from direct (eg, acute traumatic injuries) or indirect (eg, underlying illness/condition) causes, with external/environmental factors also implicated in some events.3 An understanding of the people that are most at risk and the leading causes of deaths in sporting environments, is a crucial first step toward implementing appropriate emergency management plans to prevent fatalities. ...

Due to the high temperatures and heat waves that are taking place, the risk of heat stroke has increased in recent years.. Heat stroke is a disorder characterized by failure of the functions of various internal organs due to an excessive increase in body temperature. Normally this should be around 37 degrees Celsius, but if it increases and exceeds 40 degrees without our body can eliminate excess heat, our nervous system begins to alter. When we become dehydrated, our body can not sweat enough to cool down and reduce its temperature, so it can increase and produce a heat stroke.. Heat stroke more easily affects the elderly, who often suffer from some previous pathology that is aggravated by the increase in their body temperature, at the same time that these pathologies in many cases prevent them from drinking enough water to rehydrate, or they simply forget to drink, suffer from inappetence, or do not give enough importance to this fact.. Children are also especially vulnerable to heat stroke, ...

Source: Adapted from the National Institutes of Health. What does the term heat stroke mean? The term heat stroke refers to a serious failure of the bodys heat-regulating mechanism resulting from excessive exposure to intense heat. also called sunstroke. To find out more about this term, please search the news section of this website for related articles and information.. ...

Children are at particular risk for heat stroke during the summer. Learn about the symptoms of heat stroke and what you can do to prevent problems.

Heat stroke is a potentially fatal condition. This article explores common signs, symptoms, and preventive measures. - Heat Stroke - Geriatrics at BellaOnline

There are a number of signs to look out for to identify if your dog is suffering from heat stress or heat stroke, as well as measures to prevent this.

Yes, your pup is your top fan and loyal supporter, but also vulnerable to heat and humidity. Stay on top of your dog heat stroke prevention with these tips.

Recognize the symptoms of heat stroke, like dehydration and rapid breathing, and treat your pet guinea pigs so they suffer health consequences.

It was almost 100 here today and I think one of my hens may have heat stroke.she is laying under the water bucket( mine hang) and was pretty much...

Vehicular child deaths from heat stroke - which occurs when a child dies after being left alone in a hot vehicle - are a serious problem in the U.S. Data shows that

With the same risk factors and under the same environmental conditions, heat stroke affects all races equally. However, because of differences in social advantages, the annual death rate due to enviro... more

Heat stroke can cause serious symptoms such as diarrhea, vomiting, headache, seizures, and even death. Learn to recognize the signs and symptoms.

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Seriously, I almost lost a hen yesterday to heat stroke. We saved her. Super for all. But that got me thinking, what happens when it really happens....

The ICD-10-CM Drugs Index is designed to allow medical coders to look up various medical terms and connect them with the appropriate ICD codes. There are 2 terms under the parent term Benztropine in the ICD-10-CM Drugs Index. ...

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites ...

With the arrival of summer and the heat, it is important to understand the risks to your health. Learn how to protect yourself from sunstrokes! - Proxim

How to Prevent Heat Stroke in Dogs - The blog provides tips on heat stroke prevention - like outdoor activities - & what to do if they become over-heated.

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