Given a potentially huge set of candidate criteria, our goal is to help users choose the most appropriate criteria from among the candidates. In this work, we assume that the candidate criteria exist in some document(s) in a given repository, either separately from different documents or together in the same document, and our technical objective is to rank these candidates according to their appropriateness to the task at hand. As mentioned previously, such task would be to put together a clinical trial protocol about some particular disease, treatment, or drug.. To provide a concrete idea of our problem, the following is a snippet of a clinical trial protocol, downloaded from the clinical trials website http://www.clinicaltrials.gov, and modified for presentation as an example. It shows the title, the objective of the clinical trial as well as the inclusion and exclusion criteria.. Title: Antioxidant Systems and Age-Related Macular Degeneration Objective:. The objective of this study is to ...
O:13:\PanistOpenUrl\:36:{s:10:\\u0000*\u0000openUrl\;N;s:6:\\u0000*\u0000idc\;N;s:6:\\u0000*\u0000fmt\;s:7:\journal\;s:6:\\u0000*\u0000doi\;s:0:\\;s:6:\\u0000*\u0000pii\;s:0:\\;s:7:\\u0000*\u0000pmid\;s:0:\\;s:9:\\u0000*\u0000atitle\;s:134:\A DOUBLE-BLIND CROSS-OVER TRIAL OF INDOMETHACIN, FENOPROFEN AND PLACEBO IN ANKYLOSING SPONDYLITIS, WITH COMMENTS ON PATIENT ASSESSMENT\;s:9:\\u0000*\u0000jtitle\;s:0:\\;s:9:\\u0000*\u0000stitle\;s:0:\\;s:7:\\u0000*\u0000date\;s:4:\1980\;s:9:\\u0000*\u0000volume\;s:0:\\;s:8:\\u0000*\u0000issue\;s:0:\\;s:8:\\u0000*\u0000spage\;s:0:\\;s:8:\\u0000*\u0000epage\;s:0:\\;s:8:\\u0000*\u0000pages\;s:0:\\;s:7:\\u0000*\u0000issn\;s:0:\\;s:8:\\u0000*\u0000eissn\;s:0:\\;s:9:\\u0000*\u0000aulast\;s:7:\SHIPLEY\;s:10:\\u0000*\u0000aufirst\;s:1:\M\;s:9:\\u0000*\u0000auinit\;N;s:10:\\u0000*\u0000auinitm\;N;s:5:\\u0000*\u0000au\;a:3:{i:0;s:9:\SHIPLEY M\;i:1;s:7:\BERRY H\;i:2;s:7:\BLOOM ...
Defining a sound strategy for patient recruitment is the primary theme of this, the tenth book in an evolving series of pragmatic texts written for the clinical trials professional. Because patient recruitment problems are the most important reason for the failure of clinical trials, a strong need exists for a source that gathers numerous ideas for patient recruitment. The authors provide examples of letters, brochures, announcements, and campaigns that can be sculpted to reach intended study populations. Another strength is the checklist-oriented tables and study-specific figures that are based on current clinical trials ...
GlobalDatas clinical trial report, Atopic Dermatitis Global Clinical Trials Review, H1, 2017 provides an overview of Atopic Dermatitis clinical trials scenario. This report provides top line data relating to the clinical trials on Atopic Dermatitis. Report includes an overview of trial numbers and their average enrollment in top countries conducted across the globe. The report offers coverage of disease clinical trials by region, country (G7 & E7), phase, trial status, end points status and sponsor type. Report also provides prominent drugs for in-progress trials (based on number of ongoing trials). GlobalData Clinical Trial Reports are generated using GlobalDatas proprietary database - Pharma eTrack Clinical trials database. Clinical trials are collated from 80+ different clinical trial registries, conferences, journals, news etc across the globe. Clinical trials database undergoes periodic update by dynamic process.. The report enhances the decision making capabilities and helps to create ...
Summary. GlobalDatas clinical trial report, Vitiligo Global Clinical Trials Review, H1, 2015″ provides an overview of Vitiligo clinical trials scenario. This report provides top line data relating to the clinical trials on Vitiligo. Report includes an overview of trial numbers and their average enrollment in top countries conducted across the globe. The report offers coverage of disease clinical trials by region, country (G7 & E7), phase, trial status, end points status and sponsor type. Report also provides prominent drugs for in-progress trials (based on number of ongoing trials). Global Data Clinical Trial Reports are generated using Global Data s proprietary database - Pharma eTrack Clinical trials database. Clinical trials are collated from 80+ different clinical trial registries, conferences, journals, news etc across the globe. Clinical trials database undergoes periodic update by dynamic process.. View Full Report with TOC at ...
Summary. GlobalDatas clinical trial report, Vitiligo Global Clinical Trials Review, H1, 2015″ provides an overview of Vitiligo clinical trials scenario. This report provides top line data relating to the clinical trials on Vitiligo. Report includes an overview of trial numbers and their average enrollment in top countries conducted across the globe. The report offers coverage of disease clinical trials by region, country (G7 & E7), phase, trial status, end points status and sponsor type. Report also provides prominent drugs for in-progress trials (based on number of ongoing trials). Global Data Clinical Trial Reports are generated using Global Data s proprietary database - Pharma eTrack Clinical trials database. Clinical trials are collated from 80+ different clinical trial registries, conferences, journals, news etc across the globe. Clinical trials database undergoes periodic update by dynamic process.. View Full Report with TOC at ...
GlobalDatas clinical trial report, Bronchiectasis Global Clinical Trials Review, H2, 2016 provides an overview of Bronchiectasis clinical trials scenario. This report provides top line data relating to the clinical trials on Bronchiectasis. Report includes an overview of trial numbers and their average enrollment in top countries conducted across the globe. The report offers coverage of disease clinical trials by region, country (G7 & E7), phase, trial status, end points status and sponsor type. Report also provides prominent drugs for in-progress trials (based on number of ongoing trials). GlobalData Clinical Trial Reports are generated using GlobalDatas proprietary database - Pharma eTrack Clinical trials database. Clinical trials are collated from 80+ different clinical trial registries, conferences, journals, news etc across the globe. Clinical trials database undergoes periodic update by dynamic process.. The report enhances the decision making capabilities and helps to create an ...
GlobalDatas clinical trial report, Blepharospasm Global Clinical Trials Review, H2, 2018 provides an overview of Blepharospasm clinical trials scenario. This report provides top line data relating to the clinical trials on Blepharospasm. Report includes an overview of trial numbers and their average enrollment in top countries conducted across the globe. The report offers coverage of disease clinical trials by region, country (G7 & E7), phase, trial status, end points status and sponsor type. Report also provides prominent drugs for in-progress trials (based on number of ongoing trials). GlobalData Clinical Trial Reports are generated using GlobalDatas proprietary database - Pharma eTrack Clinical trials database. Clinical trials are collated from 80+ different clinical trial registries, conferences, journals, news etc across the globe. Clinical trials database undergoes periodic update by dynamic process. The report enhances the decision making capabilities and helps to create an effective ...
Results: 210 respondents, including adults and young people with eczema plus carers of children with eczema, which included family and friends. 68% (n=126/185) reported a wide range of 38 unwanted effects. Accounts highlighted the impact on quality of life of these unwanted effects and variations to eczema management that followed. 71% (90/126) of respondents stopped a leave-on emollient due to unwanted effects. Desired characteristics in emollients related to the absence of unwanted effects and product improvements ...
To advance knowledge, identify the most effective care and help future patients, the Edwards Comprehensive Cancer Center maintains an active clinical trials program and maintains a listing of the clinical trials that are currently available.. If you have questions about whether a clinical trial is an option for you, please contact Barbara Payne, RN, OCN, CCRP, Clinical Research Supervisor. For more information about Pediatric Clinical Trials, please contact Teresa Giles at 304.399.6653.. ...
Trial registries serve as a readily accessible online resource for identifying unpublished trials and unreported outcomes. Since 2005, prospective trial registration has gained broad acceptance as an important means of enhancing transparency and tracking the existence of clinical trials at inception. Key stakeholders-including medical journal editors, legislators, and funding agencies-provide enforcement mechanisms that have greatly improved adherence to registration practices.. Basic protocol information on ongoing and completed trials of any intervention type can be retrieved via the World Health Organizations International Clinical Trials Registry Platform Search Portal (www.who.int/trialsearch/). This searches records from national and international trial registries that meet certain standards, including WHO Primary Registries and ClinicalTrials.gov. Users can search the main registry fields using key words related to the study topic, sponsor, recruitment status, and sites. When the same ...
Phenylketonuria (PKU) Global Clinical Trials Review, H1, 2016 provides an overview of Phenylketonuria (PKU) clinical trials scenario. This report provides top line data relating to the clinical trials on Phenylketonuria (PKU). Report includes an overview of trial numbers and their average enrollment in top countries conducted across the globe. The report offers coverage of disease clinical trials by region, country (G7 & E7), phase, trial status, end points status and sponsor type. Report also provides prominent drugs for in-progress trials (based on number of ongoing trials). GlobalData Clinical Trial Reports are generated using GlobalDatas proprietary database - Pharma eTrack Clinical trials database. Clinical trials are collated from 80+ different clinical trial registries, conferences, journals, news etc across the globe. Clinical trials database undergoes periodic update by dynamic process.. The report enhances the decision making capabilities and helps to create an effective counter ...
The University of Rochester Medical Center is actively engaged in clinical research with potential to improve the health of people and the communities within which they reside. The Clinical Trial Enrollment Unit of the Clinical Cardiovascular Research Center provides resources necessary to support efficient and effective study enrollment using strategic planning and bioinformatics-based tools. The unit works closely with the University of Rochester Clinical and Translational Sciences Center (UR CTSI) to leverage data driven cohort-discovery, collaborator-investigator identification and subject recruitment and retention. Our team includes health subjects coordinators and research finance specialists with diverse experience in clinical care and research involving all aspects of cardiovascular care. Our expertise includes:. ...
A new breast cancer clinical trial is testing the idea a major reason why breast cancer returns after treatment and spreads to other parts of the body is because current chemotherapy and radiation treatments do not kill the cancer stem cells. The trial involves combining standard chemotherapy with a drug that has been found in laboratory studies to attack cancer stem cells.
CHADDS FORD, PA. and BELLEVILLE, ON, Feb. 17- UROCIDIN™ PHASE III CLINICAL TRIAL RESULTS TO BE PRESENTED AT EAU AND AUA CONFERENCES.
Despite a growing interest in, and commitment to, implementing pediatric clinical trials, approximately one in every five trials in children fails because of inappropriate study design, suboptimal experiment planning, or inadequate participant enrollment. This tutorial, presented from the perspectives of seasoned pediatric investigators, an experienced research coordinator, and an established pediatric clinical trials network, is designed to provide practical guidance for successfully implementing pediatric clinical trials at an academic center or another comparable institution.
Patient recruitment and up-front enrollment planning are critical to drug development programs. Patient recruitment, if not adequately planned for, can extend your development timeline by a number of years. Retention of patients throughout the life of a clinical trial is essential in order to have complete data sets for your analysis and subsequent filings. In order to optimize both, you have to have a plan and it should take into account all stakeholders from senior management at the sponsor company and the CRO partners, to the sites and investigators and study volunteers. Cambridge Healthtech Institutes Tenth Annual Enrollment Planning and Patient Recruitment conference will cover the topics one should consider when drafting and strategically implementing a patient recruitment plan for a clinical development program.. ,p justify;\=,. ...
List of Tables. Strabismus Therapeutics, Global, Clinical Trials by Region, 2015* 7. Strabismus Therapeutics, Global, Clinical Trials and Average Enrollment by Top Countries, 2015* 8. Strabismus Therapeutics, Global, Clinical Trials In Progress by Top Countries, 2015* 9. Strabismus Therapeutics Clinical Trials, Asia-Pacific, Top Five Countries, 2015* 10. Strabismus Therapeutics Clinical Trials, Europe, Top Five Countries, 2015* 11. Strabismus Therapeutics Clinical Trials, North America, Top Countries, 2015* 12. Strabismus Therapeutics Clinical Trials, Middle East and Africa, Top Countries, 2015* 13. Strabismus Therapeutics Clinical Trials, Central and South America, Top Countries, 2015* 14. Proportion of Strabismus to Ophthalmology Clinical Trials, G7 Countries (%), 2015* 15. Strabismus Therapeutics, G7 Countries, Clinical Trials by Phase, 2015* 16. Strabismus Therapeutics, G7 Countries, Clinical Trials by Trial Status, 2015* 17. Proportion of Strabismus to Ophthalmology Clinical Trials, E7 ...
When clinical trial results just say no / Biotech companies often are able to bounce back from seeming disaster, thanks to deep reserves and partnerships Love was convinced that his San Carlos biotech companys experimental drug alfimeprase would prove effective against dangerous blood clots. Telik Inc. of Palo Alto, Renovis Inc. of South San Francisco, Berkeleys Dynavax Technologies Corp. and Threshold Pharmaceuticals in Redwood City -- have watched a once-promising lead experimental drug fall flat in the final stages of clinical trials. [...] biotech companies often manage to reinvent themselves, even after the bleakest news. Because major setbacks are so common in medical technology, experienced executives and financiers have developed ways to get companies back on track. All kinds of problems can arise, including shareholder lawsuits, departures of key staff, the loss of development partners and a much tougher climate for financing. [...] companies often have other assets they can draw on
Moderna has just announced that its RNA based vaccine is starting a phase 3 clinical trial with 30,000 subjects, so I thought it might be useful to take a look at the publicly available information about the trial, and how they got there. Lets go logically and chronologically and start with the phase 1 safety study. The Phase 1 study A phase 1 study is a safety study. They usually have relatively few subjects, and different doses are given because dosing in terms of side effects is usually an important endpoint in a safety study. Here is the Brief Summary of the Phase 1 study published by Moderna Brief Summary: This is a phase I, open-label, dose-ranging clinical trial in males and non-pregnant females, starting at 18 years of age, inclusive, who are in good health and meet all eligibility criteria. This clinical trial is designed to assess the safety, reactogenicity, and immunogenicity of mRNA-1273 manufactured by ModernaTX, Inc. mRNA-1273 is a novel lipid nanoparticle (LNP)-encapsulated mRNA-based
Science magazine reviews the disappointing results of two recent HIV vaccine clinical trials, which sugges[t] that a successful vaccine, the most ...
In this edition of the Huntingtons Disease Clinical Trials Corner we expand on the UniQure AMT-130 and on the Neurocrine Biosciences KINECT-HD trials, and list all currently registered and ongoing clinical trials in Huntingtons disease.
NEW YORK, Sept. 5, 2016 /PRNewswire/ -- AIDS - Related Lymphoma Global Clinical Trials - coverage of disease clinical trials by region, country, phase.
In the early phases of clinical trials, when the number of patients and tests are small, in-house or home-grown program are typically used to handle their data. In later phases, data volumes and complexity grow, motivating many organizations to adopt more comprehensive software. Available software includes budgeting, patient management, compliance with government regulations, project management, financials, patient management and recruitment, investigator management, regulatory compliance and compatibility with other systems such as electronic data capture and adverse event reporting systems. In addition to pharmaceutical and biotechnology industries, CTMSs are widely used at sites where clinical research is conducted such as research hospitals, physician practices, academic medical centers and cancer centers. While pharmaceutical companies that sponsor clinical trials may provide a CTMS to the sites that participate in their trials, sites may operate a CTMS to support day-to-day operations in ...
Parental comprehension and satisfaction in informed consent in paediatric clinical trials: a prospective study on childhood leukaemia ...
The three-year clinical trial results of the retinal implant popularly known as the bionic eye, have proven the long-term efficacy, safety and reliability of the device that restores vision in those blinded by a rare, degenerative eye disease. The findings show that the Argus II significantly improves visual function and quality of life for people blinded by retinitis pigmentosa.
Sensipar (Cinacalcet Hydrochloride) Drug Safety Communication - FDA Suspends Pediatric Clinical Trials After Report Of Death AUDIENCE Health Professional, Endoc
SMi Group will once again open its doors to the 11th annual Paediatric Clinical Trials conference taking place on the 20-21 March 2017 in London, UK.
© 2020 Elsevier Ltd Background: Failure to report the results of a clinical trial can distort the evidence base for clinical practice, breaches researchers ethical obligations to participants, and represents an important source of research waste. The Food and Drug Administration Amendments Act (FDAAA) of 2007 now requires sponsors of applicable trials to report their results directly onto ClinicalTrials.gov within 1 year of completion. The first trials covered by the Final Rule of this act became due to report results in January, 2018. In this cohort study, we set out to assess compliance. Methods: We downloaded data for all registered trials on ClinicalTrials.gov each month from March, 2018, to September, 2019. All cross-sectional analyses in this manuscript were performed on data extracted from ClinicalTrials.gov on Sept 16, 2019; monthly trends analysis used archived data closest to the 15th day of each month from March, 2018, to September, 2019. Our study cohort included all applicable trials due
Rare Cancer News & Clinical Trials » Trial - Brain Tumor » Neurophysiological Evaluation of Training Effect on Cancer-Related ...
Guidance for Industry Information Program on Clinical Trials for Serious or Life-Threatening Diseases and Conditions U.S. Department of Health and Human Services Food and Drug Administration Center for
Cape Tribulation in Tropical North Queensland lays claim to the worlds best beaches and the oldest surviving rainforest, The Daintree. This budget-friendly day tour from Cairns covers two world heritage sites in one spectacular day. Enjoy a day in paradise with ample free time to explore Mossman Gorge, take a walk on the beach and enjoy a meal at the Cape Tribulation Beach House. Transfers are available from Cairns or Port Douglas so sit back and enjoy the scenery on the coastal drive with stops at the Alexandra Range lookout, the Daintree Rainforest and Cape Tribulation. *This tour option does NOT include the Wildlife River Cruise.. ...
The Spanish Ministry of Health has published a draft Royal Decree on Clinical Trials, which the Spanish government is expected to adopt by the end of this
The Association of Clinical Research Professionals (ACRP) is officially partnering with the European Clinical Research Infrastructures Network (ECRIN) in honoring the extraordinary contributions of clinical researchers worldwide on International Clinical Trials? Day.
GlobalDatas clinical trial report, Candidiasis Global Clinical Trials Review, H1, 2012 provides data on the Candidiasis clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Candidiasis. It includes an overview of the trial numbers and their recruitment status as per the site of trial conduction across the globe. The databook offers a preliminary coverage of disease clinical trials by their phase, trial status, prominence of the sponsors and also provides briefing pertaining to the number of trials for the key drugs for treating Candidiasis. This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GlobalDatas team of industry experts.
GlobalDatas clinical trial report, Hemostasis Global Clinical Trials Review, H1, 2012 provides data on the Hemostasis clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Hemostasis. It includes an overview of the trial numbers and their recruitment status as per the site of trial conduction across the globe. The databook offers a preliminary coverage of disease clinical trials by their phase, trial status, prominence of the sponsors and also provides briefing pertaining to the number of trials for the key drugs for treating Hemostasis. This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GlobalDatas team of industry experts.
42-25 NCI Surgery Branch Resumes Enrollment In Suspended Immunotherapy Trials - In Brief NCI Surgery Branch Resumes Enrollment In Suspended Immunotherapy Trials    THE NCI SURGERY BRANCH resumed enrollment of patients in clinical protocols evaluating immunotherapy as a treatment for patients with metastatic cancer.
The Pediatric Trials Network (PTN) has received an award to contribute to the National Institutes of Healths (NIH) INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) project. The INCLUDE directive calls for a trans-NIH research initiative to address critical health and quality-of-life needs for individuals with Down syndrome across the lifespan.. One of the three primary components of the INCLUDE initiative is to support clinical trials on conditions and diseases that affect people with Down syndrome, both to accelerate the development of new therapies for individuals with Down syndrome and to include them in ongoing clinical trials.. PTN will work to characterize the pharmacokinetics (PK)A, pharmacodynamics (PD)B and pharmacogenomics (PGx)C of understudied off-patent drugsD administered to children and young adults with Down syndrome. By studying individuals who are receiving these drugs as part of routine care provided by their physicians, ...
On November 21, 2014, the National Institutes of Health (NIH) published a notice of proposed rulemaking that would expand the clinicaltrials.gov registration and results reporting provisions first created by the Food and Drug Administration Amendments Act (FDAAA) in 2007. (Notice available here.) NIH would require posting of results for clinical trials of unapproved and uncleared products. NIHs action follows the October 2, 2014 release of the European Medicines Agencys (EMAs) policy on the publication of clinical trial data. The current NIH proposal would not go as far as the EMA policy, which will require the EMA to publish clinical reports, and eventually individual patient data, that are submitted to the Agency in marketing authorization applications (The EMA Policy is available here). Such a requirement is still a possibility in the United States, however, as the Food and Drug Administration (FDA) has considered whether this might be appropriate under certain limited circumstances. In ...
The Clinical Study Results Database was created by the pharmaceutical trade group PhRMA as part of an industry-wide effort to expand access to clinical trial data. Moving forward, Pfizer will continue to post data from the companys late-stage clinical studies for marketed medicines ...
An HIV vaccine clinical trial is no longer happening after researchers found the vaccine ineffective in preventing new HIV infections. The National Institute of Allergy and Infectious Diseases (NIAID) had sponsored the trial and announced it was…
Before Its News). Ascites Global Clinical Trials Review, H1, 2016″ provides an overview of Ascites clinical trials scenario. This report provides top line data relating to the clinical trials on Ascites. Report includes an overview of trial numbers and their average enrollment in top countries conducted across the globe. The report offers coverage of disease clinical trials by region, country (G7 & E7), phase, trial status, end points status and sponsor type. Report also provides prominent drugs for in-progress trials (based on number of ongoing trials). GlobalData Clinical Trial Reports are generated using GlobalDatas proprietary database - Pharma eTrack Clinical trials database. Clinical trials are collated from 80+ different clinical trial registries, conferences, journals, news etc across the globe. Clinical trials database undergoes periodic update by dynamic process. For more information http://www.reportsweb.com/ascites-global-clinical-trials-review-h1-2016. Scope. - The report ...
Applied Statistics in Biomedicine and Clinical Trials Design : This volume is a unique combination of papers that cover critical topics in biostatistics from academic, government, and industry perspectives. The 6 sections cover Bayesian methods in biomedical research; Diagnostic medicine and classification; Innovative Clinical Trials Design; Modelling and Data Analysis; Personalized Medicine; and Statistical Genomics. The real world applications are in
AmerisourceBergens IntrinsiQ Specialty Solutions and ION Solutions have launched a clinical trial recruitment network, bringing healthcare providers and biopharma companies together.
TY - JOUR. T1 - A systematic review of adverse event reporting in companion animal clinical trials evaluating cancer treatment. AU - Giuffrida, Michelle. PY - 2016/11/1. Y1 - 2016/11/1. N2 - OBJECTIVE To evaluate methods used to ascertain, define, and report adverse events (AEs) in companion animal clinical trials involving cancer treatment. DESIGN Systematic review. SAMPLE English-language articles describing prospective clinical trials involving dogs and cats with naturally occurring cancer published in peer-reviewed journals between 2008 and 2014. PROCEDURES Reports were identified via MEDLINE and CAB database searches combined with a hand-searching strategy. General article characteristics were abstracted and summarized. Data for AE reporting were collected with a 14-item checklist adapted from the 2004 CONSORT extension for reporting harms. Study characteristics associated with the AE reporting checklist score were identified by means of linear regression analysis. RESULTS 168 articles with ...
Our New Medical Therapies(TM) Trial Results database provides a snapshot of results from completed and ongoing clinical trials, based on published materials from medical conferences, journals and CenterWatch reports. View COPD (Chronic Obstructive Pulmonary Disease) clinical trial results here.
Our New Medical Therapies(TM) Trial Results database provides a snapshot of results from completed and ongoing clinical trials, based on published materials from medical conferences, journals and CenterWatch reports. View Carotid Artery Disease clinical trial results here.
Free Online Library: Ruthigen Announces First Patient Enrollment in the Phase 1/2 Human Clinical Trial of RUT58-60, a Broad-Spectrum Anti-Infective Drug Candidate Designed for Prophylactic Use During Invasive Surgery. by PR Newswire; Business News, opinion and commentary Antibiotics Product development Clinical trials
TY - JOUR. T1 - Limited Generalizability of Registration Trials in Hepatitis C. T2 - A Nationwide Cohort Study. AU - Berden, Floor A C. AU - de Knegt, Robert J. AU - Blokzijl, Hans. AU - Kuiken, Sjoerd D. AU - van Erpecum, Karel J L. AU - Willemse, Sophie B. AU - den Hollander, Jan. AU - van Vonderen, Marit G A. AU - Friederich, Pieter. AU - van Hoek, Bart. AU - van Nieuwkerk, Carin M J. AU - Drenth, Joost P H. AU - Kievit, Wietske. PY - 2016. Y1 - 2016. N2 - BACKGROUND: Approval of drugs in chronic hepatitis C is supported by registration trials. These trials might have limited generalizability through use of strict eligibility criteria. We compared effectiveness and safety of real world hepatitis C patients eligible and ineligible for registration trials.METHODS: We performed a nationwide, multicenter, retrospective cohort study of chronic hepatitis C patients treated in the real world. We applied a combined set of inclusion and exclusion criteria of registration trials to our cohort to ...
A University of Oklahoma and Mercy Hospital Oklahoma City research team is set to begin the largest breast cancer clinical trial ever performed in Oklahoma. The team has developed new breast cancer risk prediction models based on a computer-aided image feature analysis scheme to identify patients who might have cancers that are not visible on mammography. After review of 2,000 imaging studies performed at Mercy over the past two years and refinement of the image analysis system, the clinical trial begins July 1, 2017, at the Mercy Breast Center.
September 26,2016. The Michael J. Fox Foundation for Parkinsons Research (MJFF) is one of 14 finalists selected to attend the Inspiring Hope Ideathon, an initiative to raise awareness of clinical trial participation and develop solutions to address this critical need in the research process. The Foundation was chosen for its submission around promotion of its online clinical study Fox Insight, a platform for people with Parkinsons disease and their loved ones to contribute health and wellness data from their own homes to help shape research priorities toward better treatments.. Members of the Fox Insight team will participate in a two-day workshop hosted by the Center for Information and Study on Clinical Research Participation and INC Research Holdings, Inc. in Boston on September 27 - 28 to further develop and cultivate plans for enhanced recruitment of the study tool. One winning project will be awarded $10,000 toward implementation of their idea.. Across all diseases, 85 percent of ...
Background With the persistent challenges towards controlling the HIV epidemic, there is an ongoing need for research into HIV vaccines and drugs. Sub-Saharan African countries - worst affected by the HIV pandemic - have participated in the conduct of clinical trials for HIV vaccines. In Kenya, the Kenya AIDS Vaccine Initiative (KAVI) at the University of Nairobi has conducted HIV vaccine clinical trials since 2001. Methodology Participants were recruited after an extensive informed consent process followed by screening to determine eligibility. Screening included an assessment of risk behavior, medical history and physical examination, and if clinically healthy, laboratory testing. In the absence of locally derived laboratory reference ranges, the ranges used in these trials were derived from populations in the West. Principal findings Two hundred eighty-one participants were screened between 2003 and 2006 for two clinical trials. Of these, 167 (59.4%) met the inclusion/exclusion criteria. Overall,
Joining a Clinical Trial. Participating in clinical trials is not for everyone. If you are interested, you can learn more about participating in a clinical trial from the resources linked below.. A Participants Guide to Mental Health Clinical Research. Clinical Trials and Older People ~ tips from the National Institute on Aging. Listings of Clinical Trials. Clinicaltrials.gov ~ A database of publicly and privately supported clinical studies being conducted around the world.. Clinical Trials by State ~ search for clinical trials by state. National Institute on Mental Health ~ listing of clinical trials on the NIMH website. Local Clinical Trials. It can be challenging to find psychiatric clinical trials in New Hampshire. Below are locations in the state that frequently conduct open clinical trials. Please note that NAMI NH is providing this information as a general resource. NAMI NH does not endorse or recommend any particular organizations, trials, treatments, or medications.. Healthy ...
List of Tables. Gastritis Therapeutics, Global, Clinical Trials by Region, 2015* 7. Gastritis Therapeutics, Global, Clinical Trials and Average Enrollment by Top Countries, 2015* 8. Gastritis Therapeutics, Global, Clinical Trials In Progress by Top Countries, 2015* 9. Gastritis Therapeutics Clinical Trials, Asia-Pacific, Top Five Countries, 2015* 10. Gastritis Therapeutics Clinical Trials, Europe, Top Countries, 2015* 11. Gastritis Therapeutics Clinical Trials, North America, Top Countries, 2015* 12. Gastritis Therapeutics Clinical Trials, Middle East and Africa, Top Countries, 2015* 13. Gastritis Therapeutics Clinical Trials, Central and South America, Top Countries, 2015* 14. Proportion of Gastritis to Gastrointestinal Clinical Trials, G7 Countries (%), 2015* 15. Gastritis Therapeutics, G7 Countries, Clinical Trials by Phase, 2015* 16. Gastritis Therapeutics, G7 Countries, Clinical Trials by Trial Status, 2015* 17. Proportion of Gastritis to Gastrointestinal Clinical Trials, E7 Countries (%), ...
Clinical trial results of a device invented at the Texas Heart Institute were presented at The Society for Cardiovascular Angiography Interventions 2019 Scientific Sessions.
Background Several clinical trials have performed riskCbenefit analyses comparing docetaxel and pemetrexed or docetaxel and vinca alkaloid, but the efficacy and safety remain uncertain. neutropenia and febrile neutropenia ( em P /em 0.05), but there was no difference in non-hematological toxicity ( em P /em 0.05). Docetaxel led to a lower rate of anemia as first-line treatment ( em P /em 0.05). Moreover, docetaxel caused less grade 3/4 hematological and non-hematological toxicity compared with vinca alkaloid. Conclusion Docetaxel leads to a better result than vinca alkaloid in effectiveness and safety on patients with advanced non-small-cell lung cancer as first-line therapy. Docetaxel also causes lower toxicity as second-line therapy compared with vinca alkaloid. However, the differences in efficacy and safety PD0325901 manufacturer between docetaxel and pemetrexed are not obvious. Further clinical study with more details, such as sex, age, histology, and so on, should be considered for ...
Rare Cancer News & Clinical Trials » Trial - Bile Duct Cancer » A Pilot Study to Assess Theragnostically Planned Liver Radiation With Functional DVH Analysis to Optimize Individualized Radiation ...
PRIMARY OBJECTIVES:. I. To identify participant-level factors affecting recruitment of potentially eligible participants in AIDS Malignancy Clinical Trials Consortium (AMC) studies at core and affiliated sites.. SECONDARY OBJECTIVES:. I. To describe the socio-demographic characteristics for participation and non-participation in AMC clinical trials among all approached volunteers across AMC sites.. II. To characterize socio-demographic characteristics with motivation and decision making among those who consented to participate in an AMC trial.. III. To identify the perceived barriers associated with clinical trial participation among those who did not consent to participate in an AMC clinical trial.. IV. To better understand how potential study volunteers learn about AMC clinical trials and by what means are they referred to a particular study.. OUTLINE:. Participants complete the Improving Participation in AMC Clinical Trials (IMPACTS) survey comprising questions about socio-demographic ...
TY - JOUR. T1 - Twenty years post-NIH Revitalization Act. T2 - enhancing minority participation in clinical trials (EMPaCT): laying the groundwork for improving minority clinical trial accrual: renewing the case for enhancing minority participation in cancer clinical trials.. AU - Chen, Moon S.. AU - Lara, Primo N.. AU - Dang, Julie H T. AU - Paterniti, Debora A.. AU - Kelly, Karen. PY - 2014. Y1 - 2014. N2 - The National Institutes of Health (NIH) Revitalization Act of 1993 mandated the appropriate inclusion of minorities in all NIH-funded research. Twenty years after this act, the proportion of minority patients enrolled in cancer clinical trials remains persistently low. Clinical trials are vehicles for the development and evaluation of therapeutic and preventive agents under scientifically rigorous conditions. Without representation in trials, it is projected that disparities in the cancer burden for minorities will increase. For this review article, the authors counted the frequency with ...
RnRMarketResearch.com adds report Relapsed Chronic Lymphocytic Leukemia (CLL) Global Clinical Trials Review, H1, 2014 to its store.. Relapsed Chronic Lymphocytic Leukemia (CLL) Global Clinical Trials Review, H1, 2014″ provides data on the Relapsed Chronic Lymphocytic Leukemia (CLL) clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Relapsed Chronic Lymphocytic Leukemia (CLL). It includes an overview of the trial numbers and their recruitment status as per the site of trial conduction across the globe. The databook offers a preliminary coverage of disease clinical trials by their phase, trial status, prominence of the sponsors and also provides briefing pertaining to the number of trials for the key drugs for treating Relapsed Chronic Lymphocytic Leukemia (CLL). This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GlobalDatas team of industry ...
note = {The recent success of companion diagnostics along with the increasing regulatory pressure for better identification of the target population has created an unprecedented incentive for the drug discovery companies to invest into novel strategies for stratified biomarker discovery. Catching with this trend, trials with stratified biomarker in drug development have quadrupled in the last decade but represent a small part of all Interventional trials reflecting multiple co-developmental challenges of therapeutic compounds and companion diagnostics. To overcome the challenge, varied knowledge management and system biology approaches are adopted in the clinics to analyze/interpret an ever increasing collection of OMICS data. By semi-automatic screening of more than 150,000 trials, we filtered trials with stratified biomarker to analyse their therapeutic focus, major drivers and elucidated the impact of stratified biomarker programs on trial duration and completion. The analysis clearly shows ...
None of the published trials included in this review met all four WHO-based criteria (table 3). Despite rigorous searching, we found only one study evaluating the efficacy and safety of a metformin FDC versus concomitant use of the component drugs as SDFs; it was underpowered and of poor quality.23 Most studies only compared metformin FDCs with monotherapies. Overall, more than half of the published trials were conducted in the USA, while only three were conducted in India. Only two trials were published prior to CDSCO approval (glimepiride and glimepiride/pioglitazone), of which only one study was conducted on Indian patients prior to its launch in India.25 30 The Indian study evaluated the efficacy of the FDC in just 101 patients with type 2 diabetes over 2 months of treatment.25 The overall lack of publicly available India-specific data heightens the need for publication of unpublished trials with Indian patients (see online supplementary table 2). India has only required registration with ...
Before Its News). , Pancreatic Fistula Global Clinical Trials Review, H1, 2016″ provides an overview of Pancreatic Fistula clinical trials scenario. This report provides top line data relating to the clinical trials on Pancreatic Fistula. Report includes an overview of trial numbers and their average enrollment in top countries conducted across the globe. The report offers coverage of disease clinical trials by region, country (G7 & E7), phase, trial status, end points status and sponsor type. Report also provides prominent drugs for in-progress trials (based on number of ongoing trials). GlobalData Clinical Trial Reports are generated using GlobalDatas proprietary database - Pharma eTrack Clinical trials database. Clinical trials are collated from 80+ different clinical trial registries, conferences, journals, news etc across the globe. Clinical trials database undergoes periodic update by dynamic process. For more information ...
Biostatistics, Designing Clinical Trials, and Evidence-Based Medicine - Clinical trials has become the most effective method to verify the physiologic
Biostatistics, Designing Clinical Trials, and Evidence-Based Medicine - Clinical trials has become the most effective method to verify the physiologic
The U.S. Food and Drug Administration (FDA) announced the availability of the Draft Guidance Master Protocols: Efficient Clinical Trial Design Strategies to Expedite Development of Cancer Drugs and Biologics.. Master protocol trial designs are complex due to the concurrent evaluation of multiple drugs and/or disease populations within a single trial, as well as their potential regulatory impact. It is important that the trials are well designed and well conducted to ensure patient safety and to obtain quality data that may support drug approval. This Draft Guidance provides advice to pharmaceutical sponsors, the academic community, institutional review boards, and the public on aspects of master protocol designs and trial conduct that pose additional regulatory consideration, such as biomarker development and statistical analysis considerations. The Draft Guidance also provides advice on the information that sponsors should submit to the FDA and how sponsors can interact with the FDA to ...
Background: The majority of hematologic malignancies are most frequently diagnosed in patients over 65 years of age (1). However, older adults are underrepresented in clinical trials evaluating new cancer therapies (2). This analysis quantifies age related enrollment in trials evaluating patients with hematologic malignancies submitted to FDA in support of drug approval. Methods: We retrospectively analyzed demographic datasets of patients enrolled to trials submitted to FDA in support of approval of new or supplemental indications for hematologic cancer therapies from 2005-2015. Patients enrolled in trials for hematologic malignancies were grouped into disease categories based on the diagnosis specified for trial entry and analyzed according to age distributions of ,65, 65-74 and ≥ 75 years. The rates of enrollment for patients with chronic myeloid leukemia (CML), chronic lymphocytic leukemia (CLL), multiple myeloma (MM) and lymphomas (Hodgkins and non-Hodgkins lymphoma excluding CLL) were ...
Trial met all primary and secondary endpoints -. - Safety as expected -. - Progressing to China NDA submission mid-2017 -. - Full data to be reported at an upcoming scientific meeting in mid-2017 -. Shanghai: Friday, March 3, 2017: Hutchison MediPharma(HMP) today announces top-line results from FRESCO, its Phase III pivotal registration trial of fruquintinib in 416 patients with locally advanced or metastatic colorectal cancer (CRC) in China, who failed at least two prior chemotherapies, including fluoropyrimidine, oxaliplatin and irinotecan. The trial met its primary endpoint of demonstrating a clinically meaningful and a statistically significant increase in overall survival (OS), in the intention-to-treat (ITT) population of patients treated with fruquintinib plus best supportive care (BSC) as compared to patients treated with placebo plus BSC. Chi-Med is currently preparing to submit a new drug application (NDA) for fruquintinib to the China Food and Drug Administration.. In ...
Clinical trials are research studies that directly involve patients. They stem from a need to identify better treatments. They are the most responsible, coordinated way to evaluate the safety, effectiveness, dose, and outcomes for new therapies. Many of todays standard cancer treatments were first proven to be effective in carefully planned clinical trials. Want to participate in a study? Search the open clinical trials at Wilmot Cancer Institute.. Wilmot Cancer Institute offers the largest portfolio of clinical trials for gynecologic cancers in the region. The Gynecologic Oncology division is a member of the NRG, a cooperative group funded by the National Cancer Institute - allowing our eligible patients access to NRG clinical trials.. ...
These questions are answered by a series studies collectively known as clinical trials. Each individual question is called a Phase. All Phase I clinical trials address the question of safety…Phase II trials address the question of whether the medication works…and Phase III trials address the question of whether the new treatment works better than old treatments.. People volunteer to participate in clinical trials for a number of really good reasons. Clinical trials can give people access to new research treatment before they become widely available… allow them to get treatment at a leading health care facility… and make a contribution to medical science. Of course, there are some major risks, depending on which Phase is being tested. For example, patients in Phase I run the risk of side effects, and patients in Phase II or Phase III may be placed in a research group that does not received the new treatment (receiving, instead, either an ineffective placebo or a different treatment, ...
The Juvenile Diabetes Research Foundation, a leader in setting the agenda for diabetes research worldwide and the largest charitable funder and advocate of type 1 research, announced today that it has launched an online service for people with type 1 diabetes and their families to easily find information about clinical trials for drugs, treatments and therapeutics for diabetes and its complications.
FDA Anti-Infective Drugs Advisory Committee. Design Issues in ABS Trials: Surrogates Endpoints & Non-Inferiority Trials October 29, 2003 Thomas R. Fleming, Ph.D. Professor and Chair of Biostatistics University of Washington. Design Issues in ABS Trials. Criteria for Study Endpoints Slideshow 6407475 by kamal-huff
... WOBURN Mass. May 16 /- BioVex Inc a biotechnology...Senior clinical investigator Neil N. Senzer M.D. will presentup-to...A summary of the abstract follows: ...Background: OncoVEX GM-CSF is a second generation oncolytic herpessim...,BioVex,to,Report,Phase,II,Clinical,Trial,Results,of,OncoVEX,GM-CSF,in,Metastatic,Melanoma,at,the,2008,American,Society,of,Clinical,Oncology,Meeting,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health
Healthy clinical trial. Clinical trial for Can Creatine Supplementation Reduce the Negative Effect of Mental Fatigue on Cognitive Performance?.
Milwaukee-based Froedtert & the Medical College of Wisconsin Cancer Network plans to leverage IBM Watsons cognitive computing to help match cancer patients with clinical trials.. The Froedtert & MCW Cancer Network, a partnership between Froedtert Health and the Medical College of Wisconsin, is the first in Wisconsin and among the first cancer programs in the nation to use Watson for clinical trial matching, according to a press release. The matching program is slated to begin in the fall.. Clinical trials are vital for developing new treatment options for cancer. Finding and enrolling eligible patients in clinical trials is difficult, and less than five percent of cancer patients are participating in a trial, according to IBM. Watson for Clinical Trial Matching is designed to complete the data-intensive process of matching patients with clinical trials, and provide doctors the information they need to advise their patients about relevant studies.. For example, after a clinician submits a ...
If you are being treated by an oncologist for NSCLC with a KRAS mutation, ask your doctor about the possibility of enrolling in a clinical trial such as RAMP 202. You can also visit www.ramp202study.com to learn more, and to take an initial online pre-screening to determine if you might be considered eligible to participate in the clinical trial.. (BPT) - According to a study published by the National Institutes of Health, non-small cell lung cancer (NSCLC), which makes up over 80% of lung cancers, is the single leading cause of cancer deaths in the world. NSCLC is typically diagnosed in patients over the age of 65. And according to the National Cancer Institute, non-small cell lung cancer is not as sensitive to treatments like chemotherapy and radiation therapy as other forms of cancer.. In some cases, NSCLC can be treated with surgery, or a combination of surgery followed by chemotherapy. Where surgery is not possible, radiation therapy is also a possible treatment, alone or combined with ...
Following successful treatment of a symptomatic UTI you may want to consider alternatives to help prevent recurrence of UTIs.. To prevent recurrent UTIs. Remember to drink plenty of water and empty your bladder fully each time you go to the toilet.. Antibiotics. A course of antibiotics will likely be prescribed by your doctor to treat the symptoms of a UTI. If you experience recurrent UTIs, your doctor may consider antibiotics to help prevent the next UTI. There are concerns about frequent use of antibiotics [1], so alternatives for preventing recurrent UTIs are becoming important.. Cranberry and natural remedies. There is some research that shows cranberry‐containing products may help to prevent UTIs by lowering the ability of E. coli to stick to the urinary tract lining. However, only a small potential benefit has been demonstrated and the current clinical trial evidence does not support the use of cranberry‐containing products for the prevention of UTIs [2]. Antibacterials. Hiprex™ is ...
Cancer treatment evolves through oncology clinical trials. Cancer trials are multimodal and complex. Assuring high-quality data are available to answer not only study objectives but also questions not anticipated at study initiation is the role of quality assurance. The National Cancer Institute reorganized its cancer clinical trials program in 2014. The National Clinical Trials Network (NCTN) was formed and within it was established a Diagnostic Imaging and Radiation Therapy Quality Assurance Organization. This organization is Imaging and Radiation Oncology Core, the Imaging and Radiation Oncology Core Group, consisting of 6 quality assurance centers that provide imaging and radiation therapy quality assurance for the NCTN. Sophisticated imaging is used for cancer diagnosis, treatment, and management as well as for image-driven technologies to plan and execute radiation treatment. Integration of imaging and radiation oncology data acquisition, review, management, and archive strategies are essential
BACKGROUND:. More than one-third of patients with coronary disease have low high density lipoprotein cholesterol (HDLc) levels (less than 35 mg/dl; United States 20th percentile) and normal low density lipoprotein cholesterol (LDLc) (less than 145; United States mean), a group for whom current treatment guidelines are not based on clinical trial data. Low HDLc levels are strong, independent predictors of cardiovascular disease and cardiovascular mortality risk, equally so for both men and women. This high coronary artery disease risk may be due to an imbalance between delivery of cholesterol into the arterial intima by LDL and its removal by HDL. Also, since HDL serve as antioxidants and cytoprotectants, an important HDL role may be to prevent LDL oxidation and thus limit macrophage-mediated intimal lipid accumulation or to prevent vascular cell toxicity. Recent epidemiologic, experimental, and clinical trial evidence suggests that a 15 mg/dl rise in HDL cholesterol would reduce coronary ...
The report provides data on the Hemorrhoids clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Hemorrhoids. It includes an overview of the trial numbers and their recruitment status as per the site of trial conduction across the globe. The databook offers a preliminary coverage of disease clinical trials by their phase, trial status, prominence of the sponsors and also provides briefing pertaining to the number of trials for the key drugs for treating Hemorrhoids ...
A prerequisite of evidence based healthcare is that medical interventions are analysed in clinical trials and the findings from these trials are used to inform decision making in the healthcare system. The selective publication of clinical trials (publication bias) and their outcomes (outcome reporting bias) have been identified as major problems distorting the scientific evidence available. As a result, perception of the effects of healthcare interventions based on published literature is biased towards overestimating benefits and underestimating harms.1 2 3 4 5 This problem of distorted public record is widely prevalent.6. To solve the problem, study registration (disclosure at inception that a study is being conducted) and results registration (posting of results after a study has been completed) have been partly implemented using publicly accessible databases. Usually, the details provided at inception and after completion both include information on study methods.. Initiatives to promote ...
Clinical trials on Ayurvedic drugs are clinical trials carried out on Ayurvedic medicine. Preliminary research has been conducted into the use of ayurvedic remedies for treating rheumatoid arthritis, but no firm evidence was produced.[1] The U.S. National Institutes of Health states that Most clinical trials of Ayurvedic approaches have been small, had problems with research designs, or lacked appropriate control groups, potentially affecting research results.[2] The Indian Council of Medical Research has issued guidance on conducting trials of ayurvedic substances. It says the substances must adhere to the recipes traditionally used and care must be taken to ensure there is no contamination of plant ingredients (e.g., by herbicides).[3] The government of India has issued draft guidelines.[4] According to Cancer Research UK, there is no scientific evidence to prove that Ayurvedic medicine can treat or cure cancer or any other disease.[5] ...
Recombinant Human C1 Esterase Inhibitor/ conestat alfa].. The ongoing pediatric study is an open label Phase II clinical trial assessing safety, immunogenicity and efficacy in children 2-13 years of age with C1INH deficiency. Eight children were treated on demand for 28 HAE attacks at 50 IU/kg body weight (up to a maximum of 4200 IU). Efficacy endpoints were time to onset of relief and to minimal symptoms, assessed by the patient (assisted by their parent), using a visual analogue scale (VAS) and by physicians using an Investigator Score. Median time to beginning of relief was 60 minutes as determined by the patients and the investigators. Using the VAS, 93% of patients had onset of relief within 2 hours. No related serious adverse events, including hypersensitivity reactions, were reported.. We believe the additional body of pediatric clinical data in children under 13 years of age are in line with the excellent data in adolescents (13-18 years of age) and adult HAE patients treated with ...
Researchers at UMMC are committed to discovering new and innovative ways to prevent and treat the diseases that affect our daily lives, with the ultimate goal to improve the well-being of our families, friends, communities and future generations. However, we cannot do it alone. Clinical research studies are vital to the advancement of medicine and our vision to create a healthier Mississippi.. Browse our ongoing clinical trials below, and use the left-hand filters to narrow your search.. To learn more about our clinical trials and how to participate, click here.. ...
Researchers at UMMC are committed to discovering new and innovative ways to prevent and treat the diseases that affect our daily lives, with the ultimate goal to improve the well-being of our families, friends, communities and future generations. However, we cannot do it alone. Clinical research studies are vital to the advancement of medicine and our vision to create a healthier Mississippi.. Browse our ongoing clinical trials below, and use the left-hand filters to narrow your search.. To learn more about our clinical trials and how to participate, click here.. ...
NICMs 2017 Symposium, Clinical Trials in Integrative Medicine: Challenges and Opportunities, will take place on the 16 November 2017 at 1PSQ, Western Sydney University Parramatta City campus.. Clinical trials explore whether a medical strategy, treatment, drug or device is safe and effective for humans. Clinical trials in integrative medicine pose a unique challenge due to the complex nature of the interventions.. This symposium will discuss the challenges and opportunities of clinical trials by exploring novel clinical trial designs, strategies for translation of evidence into practice and promoting collaborations between relevant research institutes, practitioners in the community, industry and government organisations both nationally and internationally.. Bringing together leading researchers, clinicians, practitioners, research collaborators and industry decision makers from around Australia, the symposium will explore key issues affecting the health and medical research and innovation ...
In the past 12 years, four large-scale efficacy trials of HIV vaccines have been conducted in various populations. Results from the most recent trial-the RV144 trial in Thailand, which found a 31 percent reduction in the rate of HIV acquisition among vaccinated heterosexual men and women-have given scientists reason for cautious optimism. Yet building on these findings could take years, given that traditional HIV vaccine clinical trials are lengthy, and that it is still not known which immune system responses a vaccine needs to trigger to protect an individual from HIV infection.. To accelerate HIV vaccine development, scientists working at and funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, propose using adaptive clinical trial designs. These designs allow a trial to be modified in response to data acquired during the study. Such trials would rapidly screen out poor vaccine candidates, enable extended evaluation of ...
The goal of this clinical research study is to find lymph nodes before surgery using a dye called indocyanine green (IC-Green). Objectives: 1. To determine the...
The study was approved by a Research Ethics Committee and received authorisation from the Medicines and Healthcare Products Regulatory Authority. Patients received verbal and written information prior to consenting to the trial and had the time to consider their participation and opportunity to ask questions. Patient data and samples were anonymised so that their information was kept confidential ...
This press release contains forward-looking statements, including statements related to the potential safety and efficacy of CPI-006, the Companys ability to develop and advance product candidates into and successfully complete clinical trials, including the Companys Phase 1 clinical trial of CPI-006 for COVID-19. All statements other than statements of historical fact contained in this press release are forward-looking statements. These statements often include words such as believe, expect, anticipate, intend, plan, estimate, seek, will, may or similar expressions. Forward-looking statements are subject to a number of risks and uncertainties, many of which involve factors or circumstances that are beyond the Companys control. The Companys actual results could differ materially from those stated or implied in forward-looking statements due to a number of factors, including but not limited to, risks detailed in the Companys Quarterly Report on Form 10-Q for the quarter ...
Seattle Cancer Care Alliance was formed, in part, to bring promising new treatments to patients faster. This means more treatment options at SCCA than you might find elsewhere, including the chance to participate in one of many ongoing clinical trials conducted at SCCA and its parent organizations, Fred Hutchinson Cancer Research Center and UW Medicine.. ...
Phase I (one) medical and clinical trial recruitment. Volunteer to join trials or advertise a clinical trial or medical study on MedTrials.
Currently, sponsors are not required to report the outcomes of clinical research on drugs or devices that do not lead to an approved product. Consequently, the public cannot benefit from scientific information derived from all failed or abandoned drugs and devices. Provisions in the U.S. Food and Drug Administration Amendments Act of 2007 provide an opportunity for the Department of Health and Human Services to rectify this situation. By reporting the results of clinical trials of abandoned products in a publicly accessible database and in the peer-reviewed journal literature, sponsors would satisfy a core ethical obligation of clinical research and enhance translational science.. ...
Training in Good Clinical Practice (GCP) is designed to prepare research staff in the conduct of clinical trials. Completion of GCP training will demonstrate that individuals have attained the fundamental knowledge of clinical trial quality standards for designing, conducting, recording and reporting trials that involve human research participants. GCP training complements other required training on protections for human research participants.. ...
Reasons for treatment of CML with ASCT that does not result in remission may include leukemic cells not eradicated by the high-dose chemotherapy or leukemic cells present in the infused stem cells. Researchers continue to investigate new ways to improve the results of ASCT.. The development of more effective cancer treatments requires that new and innovative therapies be evaluated with cancer patients. Clinical trials are studies that evaluate the effectiveness of new drugs or treatment strategies. Future progress in the treatment of chronic myeloid leukemia will result from the continued evaluation of new treatments in clinical trials. Participation in a clinical trial may offer patients access to better treatments and advance the existing knowledge about treatment of this cancer. Patients who are interested in participating in a clinical trial should discuss the risks and benefits of clinical trials with their physician. Areas of active investigation aimed at improving autologous stem cell ...