TY - JOUR. T1 - Polymeric catenanes synthesized via click chemistry and atom transfer radical coupling. AU - Bunha, Ajaykumar. AU - Cao, Peng Fei. AU - Mangadlao, Joey. AU - Shi, Fei Mo. AU - Foster, Edward. AU - Pangilinan, Katrina. AU - Advincula, Rigoberto. PY - 2015/5/1. Y1 - 2015/5/1. N2 - A novel route for the synthesis of polymeric catenanes was demonstrated by grafting an alkyne functionalized polymer onto a supramolecularly templated azide terminated ligand followed by ring closure via atom transfer radical coupling (ATRC). The polymeric catenane was characterized via GPC and AFM imaging. This journal is. AB - A novel route for the synthesis of polymeric catenanes was demonstrated by grafting an alkyne functionalized polymer onto a supramolecularly templated azide terminated ligand followed by ring closure via atom transfer radical coupling (ATRC). The polymeric catenane was characterized via GPC and AFM imaging. This journal is. UR - ...
TY - JOUR. T1 - Bioinspired glycosaminoglycan hydrogels via click chemistry for 3D dynamic cell encapsulation. AU - Kuang, Liangju. AU - Damayanti, Nur P.. AU - Jiang, Chunhui. AU - Fei, Xing. AU - Liu, Wenjie. AU - Narayanan, Naagarajan. AU - Irudayaraj, Joseph Maria Kumar. AU - Campanella, Osvaldo. AU - Deng, Meng. PY - 2019/2/5. Y1 - 2019/2/5. N2 - Cell encapsulation within 3D hydrogels is an attractive approach to develop effective cell-based therapies. However, little is known about how cells respond to the dynamic microenvironment resulting from hydrogel gelation-based cell encapsulation. Here, a tunable biomimetic hydrogel system that possesses alterable gelation kinetics and biologically relevant matrix stiffness is developed to study 3D dynamic cellular responses during encapsulation. Hydrogels are synthesized by crosslinking thiolated hyaluronic acid and thiolated chondroitin sulfate with poly(ethylene glycol) diacrylate under cell-compatible conditions. Hydrogel properties are ...
Poly(ethylene glycol) (PEG) is one of the most extensively studied antifouling coatings due to its ability to reduce protein adsorption and improve biocompatibility. Although the use of PEG for antifouling coatings is well established, the stability and density of PEG layers are often inadequate to provide optimum antifouling properties. To improve on these shortcomings, we employed the stepwise construction of PEG layers onto a silicon surface. Acetylene-terminated alkyl monolayers were attached to nonoxidized crystalline silicon surfaces via a one-step hydrosilylation procedure with 1,8-nonadiyne. The acetylene-terminated surfaces were functionalized via a copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction of the surface-bound alkynes with an azide to produce an amine terminated layer. The amine terminated layer was then further conjugated with PEG to produce an antifouling surface. The antifouling surface properties were investigated by testing adsorption of human serum albumin ...
TY - JOUR. T1 - A strategy for conditional orthogonal sequential CuAAC reactions using a protected aromatic ynamine. AU - Hatit, Marine Z. C.. AU - Seath, Ciaran P.. AU - Watson, Allan J. B.. AU - Burley, Glenn A.. N1 - This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Organic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.joc.7b00545.. PY - 2017/4/28. Y1 - 2017/4/28. N2 - A method for conditional control of orthogonal sequential Cu-catalyzed azide alkyne cycloaddition (CuAAC) reactions is reported. The inherent reactivity of an aromatic ynamine is controlled by a silyl protecting group that allows the selective CuAAC reaction of less reactive alkynes. Alternatively, the same protected ynamine undergoes selective CuAAC reaction via silyl deprotection in situ to give theynamine click products. This ...
A number of copolymers between styrene (St) or 4-azidomethylstyrene (N 3St) and 2,3,4,5,6-pentafluorostyrene (FSt) have been prepared by atom-transfer radical polymerization (ATRP) and conventional free radical polymerization (FRP). The mode of monomer alternation in copolymers has been established unambiguously using heteronuclear multiple bond correlation (HMBC) NMR. The degree and nature of monomer alternation was found to be strongly dependent on both the solvent (or lack thereof) and the polymerization initiator. These results are in contrast to previously published studies, which rely primarily on classic analysis of monomer reactivity ratios. We proceeded to independently functionalize the N3St and FSt moieties using orthogonal click chemistries: copper-catalyzed azide-alkyne cycloaddition (CuAAC) and fluoroarene-thiol coupling (FTC). An alternating copolymer bearing -NH2 and -SO3 - functional groups was found to be a competent organocatalyst for a Henry reaction between benzaldehyde ...
A simple approach for the preparation of a clickable poly(ethylene glycol)-based hydrogel as a polymeric support for protein immobilization via photoinitiated free radical polymerization of poly(ethylene glycol) diacrylate and propargyl acrylate is established. Bioconjugation to the obtained gels was achieved by azide-alkyne click reaction with azido-functionalized anti-immunoglobulin G (anti-IgG) and anti-His tag antibodies. Evaluation of the affinities of the PEG hydrogels to the corresponding substrates (IgG and His-tagged YFP, respectively) indicates their specific binding capability. ...
The Scripps Research Institute patented the click chemistry of its discoverer, B. Sharpless (2001 Nobel Laureate). baseclick GmbH holds a worldwide license for the use of this technology in the field of nucleic acids and offers it to customers for research and diagnostics, and, increasingly, the development of pharmaceuticals through modification of RNA molecules. Other products offered by baseclick based on click chemistry are cell proliferation kits, modified oligonucleotides, FISH products, click reagents and many more ...
Amoroso, jon william (2014) reactive probes for manipulating polyketide synthases, and photoreactive probes for strained alkyne click chemistry. aguilera, javier a (2017. dissertations from 2018. amoroso, jon william (2014) reactive probes for manipulating polyketide synthases, and photoreactive fluid power with applications anthony esposito free probes for strained alkyne click chemistry. c ca-cd ce-ch ci-co cp-cz . posts fluid power with applications anthony esposito free sobre uncategorized escritos por @ofimestaaqui e ninjipisu. abdelaal, fluid power with applications anthony esposito free maged mohamed elsayed (2016), effect of post- processing heat treatment on flexural strength of zirconia for dental. free download lesson plan, resume sample and terms paper in pdf. dissertations from 2019. aguilera, javier a (2017. ca-cd. dissertations & fluid power with applications anthony esposito free theses from 2017. sylvia e. mohandas karamchand gandhi was born on 2 october 1869 to a hindu modh ...
Publication number US 9,116,128 B2. Publication type Grant. Application number US20120107177A1. Publication date August 25, 2015. Prior publication date May 3, 2012. Filing date January 9, 2012. Priority date Nov 28, 2007. Government Interests: The U.S. Government has certain rights in this invention pursuant to Grant No. HR 0011-04-1-0032 awarded by DARPA. Parent Case Text: The present application is a continuation of U.S. patent application Ser. No. 12/324,605, filed on Nov. 26, 2008, which claims the benefit under 35 U.S.C. .sctn.119 of U.S. Provisional Patent Application Ser. No. 61/004,580, filed on Nov. 28, 2007, the contents of which are incorporated herein by reference as though set forth in full. This application may also be related to the following applications and patent, the contents of which are also incorporated herein by reference as though set forth in full: U.S. application Ser. No. 12/243,580, filed on Oct. 1, 2008; U.S. application Ser. No. 11/733,480, filed on Apr. 10, 2007; ...
The Huisgen 1,3-dipolar cycloaddition of azides and acetylenes catalyzed by Cu(I) salts, leading to 1,2,3-triazoles, is one of the most versatile click reactions. We have developed a series of optimized protocols and new applications of this reaction starting from several substrates, comparing heterogeneous vs homogeneous catalysis, conventional heating vs microwave irradiation or simultaneous microwave/ultrasound irradiation. Both non-conventional techniques strongly promoted the cycloaddition (bromide → azide → triazole), that could be conveniently performed in a one-pot procedure. This was feasible even with such bulky molecules as functionalized β-cyclodextrins (β-CD), starting from 61-O-tosyl-β-CD or from heptakis[6-O-(tert-butyldimethylsilyl)]-21-O-propargyl-β-CD. Greener heterogeneous catalysis with charcoal-supported Cu(II) or Cu(I) (prepared under ultrasound) was advantageously employed. Keywords: Click chemistry; Microwave; Huisgen cyclization; Heterogeneous catalysis; ...
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TY - JOUR. T1 - Evaluation of positive inotropic activity induced by a triazole derivative using an isolated heart model. AU - Lauro, Figueroa Valverde. AU - Francisco, Díaz Cedillo. AU - Elodia, García Cervera. AU - Eduardo, Pool Gómez. AU - Maria, López Ramos. AU - Marcela, Rosas Nexticapa. AU - Lenin, Hau Heredia. AU - Betty, Sarabia Alcocer. AU - Velázquez-Sarabia, Betty M.. PY - 2014/1/1. Y1 - 2014/1/1. N2 - There are some reports which indicate that several triazole derivatives have inotropic activity; however, the cellular site and mechanism of action at cardiovascular level is very confusing. In order, to have a clear understanding of these phenomena, a triazole derivative was synthesized to evaluate its biological activity on left ventricular pressure and characterize the molecular mechanism. The Langendorff technique was used to measure changes on perfusion pressure and coronary resistance in an isolated rat heart model in absence or presence of the triazole derivative. ...
Development of high throughput assays is a crucial step in developing more efficient techniques that aid in many important areas of research today such as drug development or identification of protein structure function relationships. Integration of high throughput assays into more research efforts could drastically decrease the time and cost it takes for a new drug to hit the market. Protein Kinase A (PKA) is an extensively studied protein as it is highly upregulated in cancer and is a hot spot for drug targeting. In this work, azide-tagged PKA is covalently attached to magnetic beads using azide-alkyne cycloaddition, a well-known click chemistry reaction that selectively and covalently links two compounds. Modified PKA is attached to magnetic beads and the activity of the covalently bound PKA is determined. Significant levels of PKA activity can open the door to development of more efficient drug screening processes. It is anticipated that the azide-PKA conjugated beads will have significantly more
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Insects in the family Elateridae are commonly called click beetles (or typical click beetles to distinguish them from the related families Cerophytidae, Eucnemidae, and Plastoceridae). Other names include elaters, snapping beetles, spring beetles or skipjacks. This family was defined by William Elford Leach (1790-1836) in 1815. They are a cosmopolitan beetle family characterized by the unusual click mechanism they possess. There are a few closely related families in which a few members have the same mechanism, but all elaterids can click. A spine on the prosternum can be snapped into a corresponding notch on the mesosternum, producing a violent click that can bounce the beetle into the air. Clicking is mainly used to avoid predation, although it is also useful when the beetle is on its back and needs to right itself. There are about 9300 known species worldwide, and 965 valid species in North America. Click beetles can be large and colorful, but most are under 2 centimeters long and dull in ...
Looking for online definition of opening click in the Medical Dictionary? opening click explanation free. What is opening click? Meaning of opening click medical term. What does opening click mean?
Azide and Alkyne reactive forms of Chromeo Dyes, Chromeo 488, Chromeo 494, Chromeo 546 and Chromeo 642 for efficient fluorescent labeling by click chemistry (cycloaddition)
If 1,2,3-Triazoles are well known for their biological properties, particular attention has been recently devoted to the development of 2-pyridyl-1,2,3-triazole derivatives (or pyta) as alternative ligands to 2,2-bipyridines. This interest is explained by the easy preparation of such ligands using a click chemistry strategy (Obata et al., 2008; Schweinfurth et al., 2008), and the use of pyta derivatives as efficient chelator systems for Tc(CO)3+ or Re(CO)3+ organometallic cores (Boulay et al., 2010; Seridi et al., 2011). Recently, structural pyta isomers like 4-pyridyl-1,2,3-triazole have been described as building blocks in the synthesis of chelating agents for biomedical applications (Bonnet et al., 2012; Pellegatti et al., 2008). In this paper, we report on the first X-ray structure analysis of a 4-pyridyl-1,2,3-triazole derivative.. The title molecule, Fig. 1, can be considered as a ditopic ligand with two distinct transition metal complexing sites, the iminodiacetate (IDA) pincer and the ...
We understand that all influences, whether positive or negative, will affect our lives. Our goal at CLICKS, is to provide and support positive influences and worthwhile experiences in the lives of young people. Our curriculum and activities are concentrated in the areas of law, sports, health, and social justice. Civic engagement, volunteerism, scholastic improvement and achievement, social skills, and career planning are also highly encouraged in CLICKS programs. It is our hope that through the CLICKS program, students are injected with a working knowledge and understanding of how the law works so that as they become adults, they know how they are protected and can use the law to effect change in their communities. We are leaders on a mission to create leaders ...
Add to shortcuts. Summer weather forecast: What in store for Canadians in 2019 Click to return to homepage. Click on the Save button to add the link to the list, Click on the X button to close the panel, Click on the Delete button to remove the link from the list, Click on the Close button to save the change, Click and hold the link and move to new location in the list, Click on the Rename button and change the link name. Weather overview (Next hours and days, 14 day forecast) Meteograms (Graph 3-5 days - choose your model) Forecast XL (Graph and table up to 10 days - choose your model) Forecast Ensemble (Up to 3 models, multiple runs, graph up to 16 days) Long range forecast. Weather maps for all of the Provinces in Canada - 14-day forecast for Canada Click on the Save button to add the link to the list, Click on the X button to close the panel, Click on the Delete button to remove the link from the list, Click on the Close button to save the change, Click and hold the link ...
A very rare opportunity has been bestowed into me to work in three different facets of organic chemistry: total synthesis, methodology, and medicinal chemistry. While this intensive experience has certainly assisted me to become a better scientist, there are still many more tasks for me to accomplish. Still, I am confident that my PhD training has prepared me to embark upon the world ahead.; In chapter 1 of this thesis, I will describe the synthetic progress of two subunits, which can be coupled to make a macrolide called Palmerolide A, a bioactive molecule targeting melanoma (i.e. skin cancer). The synthesis of the first subunit is almost complete and it proceeds without significant deviation from the originally proposed scheme. The synthesis of the second subunit is halfway complete. Sensitive functional groups in the second subunit have made it more challenging to complete this piece of Palmerolide A.; A major challenge faced in the preparation of Palmerolide A was the macrocyclization step. ...
New redox labelling of DNA by an azido group which can be chemically transformed to nitrophenyltriazole or silenced to phenyltriazole was developed and applied to the electrochemical detection of DNA-protein interactions. 5-(4-Azidophenyl)-2-deoxycytidine and 7-(4-azidophenyl)-7-deaza-2-deoxyadenosine nucleosides were prepared by aqueous-phase Suzuki cross-coupling and converted to nucleoside triphosphates (dNTPs) which served as substrates for incorporation into DNA by DNA polymerase. The azidophenyl-modified nucleotides and azidophenyl-modified DNA gave a strong signal in voltammetric studies, at -0.9 V, due to reduction of the azido function. The Cu-catalyzed click reaction of azidophenyl-modified nucleosides or azidophenyl-modified DNA with 4-nitrophenylacetylene gave nitrophenyl-substituted triazoles, exerting a reduction peak at -0.4 V under voltammetry, whereas the click reaction with phenylacetylene gave electrochemically silent phenyltriazoles. The transformation of the azidophenyl ...
Herein, four new H-shaped triphenylene discotic liquid crystal tetramers have been designed and synthesized using a copper-free [3+2] cycloaddition reaction between the triphenylene dimer and diazide compounds. To probe the molecular self-assembly and mesophase properties, the length and rigid spacers in diazide have been tailored.
There is interest in improving the flavor of commercial strawberry (Fragaria × ananassa) varieties. Fruit flavor is shaped by combinations of sugars, acids and volatile compounds. Many efforts seek to use genomics-based strategies to identify genes controlling flavor, and then designing durable molecular markers to follow these genes in breeding populations. In this report, fruit from two cultivars, varying for presence-absence of volatile compounds, along with segregating progeny, were analyzed using GC/MS and RNAseq. Expression data were bulked in silico according to presence/absence of a given volatile compound, in this case γ-decalactone, a compound conferring a peach flavor note to fruits. Computationally sorting reads in segregating progeny based on γ-decalactone presence eliminated transcripts not directly relevant to the volatile, revealing transcripts possibly imparting quantitative contributions. One candidate encodes an omega-6 fatty acid desaturase, an enzyme known to participate in
In this paper we investigate the optimum procedure for the post-polymerisation modification of alkyne-bearing polymer scaffolds with glycosyl azides. We first elaborate the one-pot synthesis of glycosyl azides, in aqueous solution, without the need for protecting groups and in multigram scale. Using these az
The attempt to decorate carbon nanotubes with organic molecules to form new functional materials has attracted broad attention in the scientific community. Here, we report the covalent functionalization of multiwalled carbon nanotubes (MWCNTs) with p
A. C. Cardiel, M. C. Benson, L. M. Bishop, K. M. Louis, J. C. Yeager, Y. Tan, R. J. Hamers. Chemically Directed Assembly of Photoactive Metal Oxide Nanoparticle Heterojunctions via the Copper-Catalyzed Azide-Alkyne Cycloaddition Click Reaction. ACS Nano 2012, 6, 310-318. This article was also featured in C&EN on Jan. 23, 2012 in the News of the Week section (Volume 90, Issue 4, p. 8).. ...
Microcin J25 is a small 21-residue antimicrobial peptide exhibiting an interesting lasso motif whereby the N-terminal glycine 1 is covalently bonded via a peptide bond to the glutamic acid 8 sidechain to form a loop through which the C-terminus is threaded and sterically locked in place by bulky aromatic groups either side of the ring. This motif imparts great thermal and chemical stability, with the peptide remaining active after exposure to boiling water and high denaturant concentrations. A current experimental and theoretical collaboration between the Link and Panagiotopoulos groups is attempting to understand the formation of this structure and replicate it in vitro by click chemistry inspired incorporation of non-canonical amino acids into the native peptide. For more infomation about Professor Debenedettis research please see the Debenedetti Research Group site.. For more infomation about Professor Links research please see The Link Lab site.. For more infomation about Professor ...
2017 Taylor & Francis. The production of reactive species contributes to the age-dependent accumulation of dysfunctional mitochondria and protein aggregates, all of which are associated with neurodegeneration. A putative mediator of these effects is the lipid peroxidation product 4-hydroxynonenal (4-HNE), which has been shown to inhibit mitochondrial function, and accumulate in the postmortem brains of patients with neurodegenerative diseases. This deterioration in mitochondrial quality could be due to direct effects on mitochondrial proteins, or through perturbation of the macroautophagy/autophagy pathway, which plays an essential role in removing damaged mitochondria. Here, we use a click chemistry-based approach to demonstrate that alkyne-4-HNE can adduct to specific mitochondrial and autophagy-related proteins. Furthermore, we found that at lower concentrations (5-10 μM), 4-HNE activates autophagy, whereas at higher concentrations (15 μM), autophagic flux is inhibited, correlating with the ...
Various non-fluorescent alkynes for copper-catalyzed Click Chemistry. Fluorescent dye alkynes are listed under Reactive dyes category.
Can you pick the Buffy Quotes (Clickable)? Test your knowledge on this television quiz to see how you do and compare your score to others. Quiz by Indigo_Locke
After the meeting, Wayo goes up to Kit to get some snacks and say hi. Wayho complains of his first meeting to Ming who responds it is actually a good thing. When beginning with this series, they decided to recap the original series in the first three episodes. [Engsub BL] 2Moons2 The Series Ep.4 Date: 20 July 2019 Author: winspedia 7 Comments Wayo is accepted at the Kantaphat University, in the Faculty of Sciences; in the same institution, he studies, Phana, a second-year boy he has always been in love with, though he … Click to share on Facebook (Opens in new window), Click to share on Twitter (Opens in new window), Click to share on Tumblr (Opens in new window), Click to email this to a friend (Opens in new window), Click to share on LinkedIn (Opens in new window), Click to share on Pocket (Opens in new window), Click to share on Telegram (Opens in new window), Click to share on Reddit (Opens in new window), Click to share on Skype (Opens in new window), Click to share on WhatsApp (Opens in ...
Click beetle. Macrophotograph of an unidentified click beetle (family Elatridae) resting on a leaf. Members of this group are found throughout northern Europe and the USA. The click beetle possesses a mechanism which allows it to right itself when upside down. The head is snapped back with a large force and a loud click, propelling the beetle through the air. Magnification unknown. - Stock Image Z330/0301
Remember back in the early days of internet banner advertising, when the rules were that you had to include the phrase click here! somewhere in your banner ad to let clueless surfers know that they could actually click on the ad and dig deeper into your advertising goodness? Apparently, that old click here trick still works -- even when the ad is promising to infect your computer with a virus. A security researcher put up a Google text ad reading: Is your PC virus-free? Get it infected here! Apparently, that was enough to convince 409 people to click on the ad over the course of about 6 months. As the Wired blog post notes, its quite likely that some of those people figured it was a joke and were curious and another group probably only skimmed it quickly and naturally assumed it was for an anti-virus product. Still, its an interesting bit of data -- made even more interesting by the guy saying that no one ever complained about the ad and Google never noticed it ...
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Life Off Earth - Do Aliens Exist? by Heather Couper. [Click here].. UFOs are Real. [Click here].. Are We Alone in the Universe? by Sir Martin Rees. [Click here].. Life on Mars? by Patrick L. Barry. [Click here]. Martian Life: The NASA Cover-up? by Heather Couper and Nigel Henbest. [Click here].. Evolution of Life: A Cosmic Perspective by Chandra Wickramasinghe and Chandra Wickramasinghe [Click here]. Panspermia Theory. [Click here]. Panspermia by Chandra Wickramasinghe. [Click here].. Panspermia by Karl Sims. [Click here].. Panspermia and the Origin of Life on Earth. [Click here]. ...
TY - JOUR. T1 - Well-defined (co)polypeptides bearing pendant alkyne groups. AU - Zhao, Wei. AU - Gnanou, Yves. AU - Hadjichristidis, Nikos. N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The research reported in this publication was supported by funding from King Abdullah University of Science and Technology (KAUST).. PY - 2016. Y1 - 2016. N2 - A novel metal-free strategy, using hydrogen-bonding catalytic ring opening polymerization of acetylene-functionalized N-carboxy anhydrites of α-amino acids, was developed for the synthesis of well-defined polypeptides bearing pendant alkyne groups. This method provides an efficient way to synthesize novel alkyne-functionalized homopolypeptides (A) and copolypeptides, such as AB diblock (B: non-functionalized), ABA triblock and star-AB diblock, as well as linear and star random copolypeptides, precursors of a plethora complex macromolecular architectures by click chemistry.. AB - A novel metal-free strategy, using hydrogen-bonding ...
If you need a copy of the image without a watermark, please contact me for further information.. How to Apply Background Picture in PowerPoint. Click the slide that you want to apply a background style to. On the Design tab, in the Background group, click Background Styles, then click Format Background. Click Fill, then click Picture or texture fill. To insert a picture from a file, click File, and double-click the picture that you want to insert. Click Close.. How to Apply Background Picture in Keynote. Open the Inspector, go to the second tab (Slide inspector), then click the Appearance sub tab. Click Choose on the Image fill option, and choose your image.. License: All images available here are for personal use only. Commercial usage are not allowed. The copyright belongs to the Author. We are not responsible for the content of this Publishers Description. Do not use any of images here in violation of applicable laws. If you find any problem with certain image, please use our contact page ...
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Proteolysis targeting chimera (PROTAC) building block. Contains an E3 ligase ligand with PEG linker and terminal alkyne. Ready for conjugation to a target protein ligand through click chemistry to form PROTACs containing Lenalidomide as cereblon ligand. Product Name: Lenalidomide-acetamido-O-PEG1-propargyl Synonyms: CA
A novel biscarbazol triphenylamine end-capped dendrimeric zinc(II) porphyrin (DP 5) was synthesized by click chemistry. This compound is a cruciform dendrimer that bears a nucleus of zinc(II) tetrapyrrolic macrocycle substituted at the meso positions by four identical substituents. These are formed by a tetrafluorophenyl group that possesses a triazole unit in the para position. This nitrogenous heterocyclic is connected to a 4,4-di(N-carbazolyl)triphenylamine group by means of a phenylenevinylene bridge, which allows the conjugation between the nucleus and this external electropolymerizable carbazoyl group. In this structure, dendrimeric arms act as light-harvesting antennas, increasing the absorption of blue light, and as electroactive moieties. The electrochemical oxidation of the carbazole groups contained in the terminal arms of the DP 5 was used to obtain novel, stable, and reproducible fully π-conjugated photoactive polymeric films (FDP 5). First, the spectroscopic characteristics and ...
Thomas Reiner is the author of these articles in the Journal of Visualized Experiments: Mikroflödes On-chip Capture-cykloadditionsreaktion att reversibelt Immobilisera små molekyler eller flerkomponent Strukturer för Biosensor Applications, Utnyttja Bioorthogonal Inverse Electron Demand Diels-Alder Cykloaddition för Pretargeted PET Imaging, En omfattande förfarande för att utvärdera, En ny teknik för att generera och observera Chemiluminescence i en biologisk inställning
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Edited by renowned protein scientist and bestselling author Roger L. Lundblad, with the assistance of Fiona M. Macdonald of CRC Press, this fifth edition of the?Handbook of Biochemistry and Molecular Biology?gathers a wealth of information not easily obtained, including information not found on the web. Presented in an organized, concise, and simple-to-use format, this popular reference allows quick access to the most frequently used data. Covering a wide range of topics, from classical biochemistry to proteomics and genomics, it also details the properties of commonly used biochemicals, laboratory solvents, and reagents. An entirely new section on Chemical Biology and Drug Design gathers data on amino acid antagonists, click chemistry, plus glossaries for computational drug design and medicinal chemistry. Each table is exhaustively referenced, giving the user a quick entry point into the primary literature. New tables for this edition: Chromatographic methods and solvents Protein spectroscopy
Glycopolymers have been synthesised by post-functionalisation of well-defined alkyne-functional polymers with sugar azides to yield N-glycosyl 1,2,3-triazole functional polymers. The Cu(I)-catalysed Huisgen cycloaddition was used to attach alpha-mannoside, beta-galactoside and beta-lactoside derivatives via an azide functionality bound directly to the sugar anomeric carbon. Three different catalytic systems were investigated for the click reactions; [(PPh3)(3)Cu(I)Br], TBTA/Cu(I)Br and bathophenanthrolinedisulphonic acid disodium salt/Cu(I)Br. The latter of these was found to be the most efficient for the attachment of the larger/more sterically hindered disaccharide lactose moiety. The interaction of the lactose- and galactose-bearing glycopolymers with Ricinus Communis Agglutinin (RCA I) lectin was investigated by affinity HPLC analysis. The rate of the interaction between mannose polymer and concanavalin A (Con A) lectin was assessed by turbidimetry. The results from the lectin conjugation ...
Enzyme selectivity means that the enzyme´s preferences towards competing substrates will be different. In this thesis, the enzyme selectivity has been studied for utilization in synthesis of functionalized macromonomers. The aim was to study how the inherent -or introduced - selectivity of lipases can be used to introduce thiol‐ or enefunctionalities into short polyesters. Thiol‐ and ene‐functionalized renewable organic precursor molecules in combination with thiol‐ene click chemistry opens up for a sustainable material production. Lipases do not normally affect ene‐moieties and the preference towards thiols is low, enabling introduction of these functional groups for further modifications. In addition, lipases have been shown to be good catalysts in the formation of polyesters, both via ring‐opening and polycondensation polymerization.. In paper I Candida antarctica lipase B was used to end‐functionalize poly(ε‐caprolactone) with free thiols in a one‐pot reaction. The ...