TY - JOUR. T1 - Cimetidine Does Not Inhibit Indomethacin-Induced Small Bowel Ulceration in the Rat. AU - Kauffman, Gordon L.. AU - Foley, Kevin. AU - Grossman, Morton I.. PY - 1979/1/1. Y1 - 1979/1/1. N2 - In earlier studies, cimetidine was found to protect against acetylsalicylic acid-induced gastric mucosal lesions by a mechanism other than inhibition of gastric acid secretion. The present study examined the possibility that cimetidine might protect against the intestinal mucosal injury produced by indomethacin. Small intestinal ulceration produced by oral indomethacin (20 mg kg-1) was studied in rats treated with 0.15 M NaCl (control); 80 mg kg-1 cimetidine; 400 mg kg -1 cimetidine; and 100 μug kg-1 16-16 dimethyl prostaglandin E2. The treatments were given 30 min before and 8 hr after indomethacin. Confirming previous studies, 16-16 DMPGE2 significantly (P , 0.01) reduced the number of lesions and the sum of the lengths of ulcers per rat when compared to the control group. Neither dose of ...
Cimetidine, sold under the brand name Tagamet among others, is a histamine H2 receptor antagonist that inhibits stomach acid production. It is available over-the-counter and is mainly used in the treatment of heartburn and peptic ulcers. The development of longer-acting H2 receptor antagonists with fewer drug interactions and adverse effects, such as ranitidine and famotidine, decreased the use of cimetidine, and though it is still used, cimetidine is no longer among the more widely used of the H2-receptor antagonists.[citation needed] Cimetidine was discovered in 1971 and came into commercial use in 1977. Cimetidine was approved in the United Kingdom in 1976, and was approved in the United States by the Food and Drug Administration for prescriptions in 1979.[citation needed] Cimetidine is used to inhibit stomach acid production and is used in the treatment of heartburn and peptic ulcers. Some evidence suggests cimetidine could be effective in the treatment of common warts, but more rigorous ...
Elephant specific information, if available, is in blue.. Chemistry - An H2- receptor antagonist, cimetidine occurs as a white to off-white, crystalline powder. It has what is described as an "unpleasant" odor and a pKa of 6.8. Cimetidine is sparingly soluble in water and soluble in alcohol. Cimetidine HCl occurs as white, crystalline powder and is very soluble in water and soluble in alcohol. It has a pKa of 7.11 and the commercial injection has a pH of 3.8-6.. Storage/Stability/Compatibility - Cimetidine products should be stored protected from light and kept at room temperature. Do not refrigerate the injectable product as precipitation may occur. Oral dosage forms should be stored in tight containers.. The cimetidine injectable product is compatible with the commonly used IV infusions solu-tions, including amino acid (TPN) solutions, but should be used within 48 hours of dilution. Cimetidine is also reported to be compatible with the following drugs: acetazolamide sodium, amikacin sulfate, ...
Forty five patients with refractory oesophagitis, defined as persisting erosive changes or ulceration despite a minimum of three months treatment with cimetidine 3.2 g daily or ranitidine 0.9 g daily, were treated in an open trial with omeprazole 40 mg daily for up to eight weeks. Endoscopically defined healing was observed in 73% of patients after four weeks treatment and in 91% after eight weeks treatment. Symptoms were completely relieved in 60% of patients, improved in 34%, unchanged in 4%, and worsened in 2%. After healing patients returned to maintenance treatment with cimetidine 1.6-3.2 g daily, depending on the severity of their illness before treatment with omeprazole. By six months and 12 months only 55% and 33% of patients respectively were still in remission. This study suggests that when erosive oesophagitis is refractory to treatment with high dose cimetidine or ranitidine, treatment with omeprazole 40 mg daily for up to eight weeks is effective in inducing healing and relieving ...
The effect of two doses of cimetidine, 400 mg at night and 400 mg bd, on the protection of indomethacin (50 mg tid) induced mucosal damage was evaluated in a double blind study in patients with acute musculoskeletal disorders. Endoscopic mucosal lesions were scored before and after five to seven days of treatment. One hundred and ninety one patients were endoscoped before the trial, 34 (17.8%) had greater than one erosion and were not recruited. Forty patients were excluded for non-compliance, or lost to follow up. At the second endoscopy, oesophageal, and fundic damage was negligible. Gastric and duodenal lesion score in patients treated with cimetidine 400 mg bd: 2.7 (0.5) (SE); n = 42) was significantly lower (p less than 0.0122) than in placebo treated patients: 6.1 (0.9) (n = 50) or in patients treated with cimetidine 400 mg at night 7.1 (0.8) (n = 21). Cimetidine 400 mg bd provided significant protection for the duodenum, but its protection of antral mucosa did not reach statistical ...
An Unexpected Anti-Cancer Agent. The first studies to hint at cimetidines effectiveness against cancer were published in the late 1970s. Although scientists initially thought that cimetidine worked by enhancing immune function, later studies showed that cimetidine functions via several different pathways to inhibit tumor cell proliferation and metastasis. In a prospective, randomized, placebo-controlled study in 1988, 181 patients with gastric cancer received cimetidine (400 mg, twice daily) or placebo for two years or until death. Those given cimetidine had a significantly prolonged survival rate compared to the placebo group, particularly patients with more serious disease.1. In a 1994 study, just seven days of cimetidine treatment (400 mg twice daily for five days preoperative and intravenously for two days post-operative) in colorectal cancer patients decreased their three-year mortality rate from 41% to 7%. In addition, tumors in the cimetidine-treated patients had a notably higher rate of ...
The efficacy of Cimetidine in the prevention and treatment of stress-induced gastroduodenal lesions was evaluated in a randomized, double-blind, placebo-controlled study in which serial endoscopy was used to examine patients without clinical evidence of bleeding who were admitted to a medical intensive care unit. Endoscopy showed that 14 of 21 patients treated with Cimetidine, compared with 5 of 18 patients treated with placebo, had normal or improved gastroduodenal mucosa (p , 0.05). Endoscopic signs of bleeding cleared or did not develop in 20 patients treated with Cimetidine and in 11 patients treated with placebo (p , 0.01). Significantly fewer blood transfusions were given to patients with endoscopic signs of bleeding in the cimetidine-treated group (0.5 ±0.3 [SE] units) than in placebo-treated patients (4.5 ±1.5 units; p , 0.05). The mortality rate was not statistically different between treatment groups. By preventing established gastroduodenal stress lesions from progressing in ...
Cimetidine is a powerful H2 receptor antagonist originally designed to treat ulcers by blocking the acid producing cells in the stomach. In the study three groups of rabbits were simultaneously induced with experimental periodontitis using P. gingivalis and treated with varying levels of topically applied cimetidine three times a week over a six-week period. Results showed that topical application of cimetidine at all concentrations inhibited inflammation and bone loss by approximately 90 ...
Seven in the chlorzoxazone group and 11 in the cimetidine group were lost to follow up. Concurrent use powder with Peptol tab 400mg may automatically result in increased and prolonged blood concentrations of cimetidine. As some imipramine packaging procedures must mind be strictly observed, the sandoz is the most suitable for company
Clinical studies have indicated that suppression of nocturnal acid is the most important factor in duodenal ulcer healing (see CLINICAL PHARMACOLOGY, Antisecretory Activity, Acid Secretion). This is supported by recent clinical trials (see CLINICAL PHARMACOLOGY, Clinical Trials, Active Duodenal Ulcer). Therefore, there is no apparent rationale, except for familiarity with use, for treating with anything other than a once-daily at bedtime dosage regimen.. In a U.S. oral dose-ranging study of 400 mg at bedtime, 800 mg at bedtime and 1600 mg at bedtime, a continuous dose response relationship for ulcer healing was demonstrated.. However, 800 mg at bedtime is the dose of choice for most patients, as it provides a high healing rate (the difference between 800 mg at bedtime and 1600 mg at bedtime being small), maximal pain relief, a decreased potential for drug interactions (see PRECAUTIONS, Drug Interactions) and maximal patient convenience. Patients unhealed at four weeks, or those with persistent ...
Dyspepsia, a poorly defined syndrome of episodic or recurrent upper abdominal discomfort after eating, has an estimated prevalence of 20% to 30% in the general population. The pathophysiology of this disorder is unknown. Postulated mechanisms include gastric acid hypersecretion, gastric motility disorder, Helicobacter pylori infection, and psychogenic stress. The investigation of dyspepsia is limited to patients with systemic signs or symptoms that suggest anatomic disease; otherwise, the treatment of dyspepsia is empiric. Results of previous randomized trials have generally failed to show any advantage of antacids or cimetidine over placebo (1), although a more recent trial found a benefit of cimetidine for relief of pain (2). Johannessen and colleagues compared on-demand cimetidine with placebo in treating the symptoms of dyspepsia. Their n-of-1 design addresses a limitation of previous studies: A subgroup of responders may have been lost in the random error associated with a majority of ...
Detailed Description:. Additional Study Purpose Details: Evaluate the effects of multiple doses of cimetidine on the pharmacokinetics (e.g., elimination from the body) of a single dose of PD 0332334.. On February 18th 2009, a decision to terminate further development for PD 0332334 was communicated to investigators in this study. The decision to terminate this study was not based on any safety concerns. ...
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Effect of cimetidine on cumulative survival rates in the colorectal cancer patients. The tumour tissues from individual patients obtained during curative operat
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Cimetidine information about active ingredients, pharmaceutical forms and doses by Hi Tech Pharmaceuticals, Cimetidine indications, usages and related health products lists
Cimetidine information about active ingredients, pharmaceutical forms and doses by Sicor Pharmaceuticals, Cimetidine indications, usages and related health products lists
Cimetidine is an H2-receptor antagonist that inhibits gastric acid secretion. In pregnancy, the antihistamine is primarily used for the treatment of peptic ulcer disease and for the prevention of gastric acid aspiration (Mendelsons syndrome) prior to delivery.. In studies with multiple animal species, no evidence of impaired fertility or teratogenesis was observed with doses up to 40 times higher than the usual human dose (1). Cimetidine does have weak antiandrogenic effects in animals, as evidenced by a reduction in the size of testes, prostatic glands, and seminal vesicles (2,3), and in humans, by reports of decreased libido and impotence (4). Conflicting reports on the antiandrogenic activity in animals exposed in utero to cimetidine have been published (5,6,7,8 and 9).. Three references, all from the same research group, described the effects on male rats of exposure to cimetidine from gestation up to the time of weaning (5,6 and 7). The rats had decreased weights of testicles, prostate ...
I just got a call back from Eltons vet. He said he consulted with his neurologist and they both agree that cimetidine will not do what prilosec will in reducing the CSF fluid. He said to start on that and then try Lyrica (which he said is expensive, which I know). He then mentioned steroids. I found this on Rods website http://www.cavalierhealth.org/syringomyelia.htm (I hope you dont mind the quote. Neurologists have been prescribing cimetidine (Tagamet, Zitac), which is a histamine
Define Tagamet HB. Tagamet HB synonyms, Tagamet HB pronunciation, Tagamet HB translation, English dictionary definition of Tagamet HB. n. A histamine receptor antagonist, C10H16N6S, that inhibits acid secretion in the stomach and is used to treat duodenal and gastric ulcers and...
Somberg L, Morris Jr., Fantus R, et al. Intermittent intravenous pantoprazole and continuous cimetidine infusion: effect on gastric pH control in critically ill patients at risk of developing stress-related mucosal disease. J Trauma 2008; 64(5):1202-10. Marrone GC, Silen W. Pathogenesis, diagnosis and treatment of acute gastric mucosal lesions. Clin Gastroenterol 1984; 13(2):635-50. Hastings PR, Skillman JJ, Bushnell LS, Silen W. Antacid titration in the prevention of acute gastrointestinal bleeding: a controlled, randomized trial in 100 critically ill patients. N Engl J Med 1978; 298(19):1041-5. Martin LF, Booth FV, Karlstadt RG, et al. Continuous intravenous cimetidine decreases stress-related upper gastrointestinal hemorrhage without promoting pneumonia. Crit Care Med 1993; 21(1):19-30. Conrad SA, Gabrielli A, Margolis B, et al. Randomized, double-blind comparison of immediate-release omeprazole oral suspension versus intravenous cimetidine for the prevention of upper gastrointestinal ...
Title: MedicineNet cimetidine Specialty, Description: MedicineNet cimetidine Specialty, By: Feedage Forager, ID: 331221, Grade: 93, Type: RSS20
Robert Hodgkinson, Raymond Glassenberg, Thomas H. Joyce, Dennis W. Coombs, Gerard W. Ostheimer, Charles P. Gibbs; Comparison of Cimetidine (Tagamet®) with Antacid for Safety and Effectiveness in Reducing Gastric Acidity before Elective Cesarean Section. Anesthesiology 1983;59(2):86-90. doi: https://doi.org/.. Download citation file:. ...
TAGAMET HB SUSPENSION (Cimetidine) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
Every so often you might find that your feline friend is prescribed a drug that you might also use, and for exactly the same condition. Cimetidine, the generic name for the Tagamet brand, is one of ...
Effect of lafutidine (30 mg/kg) and cimetidine (10 mg/kg), relative to vehicle, on (A) intragastric acidity and (B) weight of gastric content measured 60 and 12
Health Products / Supplements China, Cimetidine Tablets 400mg, Indications: Treatment and maintenance therapy of active duodenal ulcer. Treatment of benign gastric ulcers . Treatment ...
Cimetidine is a histamine H2-receptor antagonist for treatment of ulcus duodeni and ulcus ventriculi. Normally, this active is wet-granulated to...
Cimetidine has been studied as an additive in cancer chemotherapy. It is claimed to reduce the side effects of Cisplatin. This study focuses on possible interactions between Cisplatin and cimetidine on the molecular level. Due to the fact that cimetidine is metabolized in the liver, interactions between its metabolites and Cisplatin are also investigated. By means of LC/ESI-MS, Cisplatin-cimetidin ...
It is widely accepted that angiotensin II, ACTH and potassium are the major factors controlling the release of aldosterone. Conflicting results have been reported about the role of serotonin,...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
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Gentaur molecular products has all kinds of products like :search , Accu \ Gerbu Adjuvant MM, contains Cimetidine & pApU \ 3001/06 for more molecular products just contact us
Histamine stimulation of adenylate cyclase activity in broken cells isolated from guinea pig gastric mucosa was competitively inhibited by the thiazole derivative ICI 125,211 and the furane derivative ranitidine, with pA2 of 7.62 (Ki = 2.39 x 10-8 M) and pA2 of 6.90 (Ki = 1.25 x 10-7 M), respectively, i.e., potencies 19 times and 4 times superior to that of the classical H2-receptor antagonist cimetidine (pA2 = 6.34; Ki = 4.57 x 10-7 M). These results are consistent with the reported pharmacological potencies of the antagonists on guinea pig right atrium and on gastric acid secretion in vivo. Thus, the requirement of an imidazole ring in the structure of H2-receptor antagonists can be definitely ruled out.. ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The algorithm (sp) on C. Rusbridges website refers to those two drugs so I Googled to see what they are used for and found they are for stomach acid. What is the connection with SM and neurological pain?
Tell your doctor or health care professional if your pain does not start to get better or gets worse. You may need to take this medicine for several days before your symptoms get better. Finish the full course of tablets prescribed by your doctor or health care professional even if you feel better.. Do not take with aspirin, ibuprofen, or other antiinflammatory medicines unless directed to do so by your health care professional. These can make your condition worse.. Do not smoke cigarettes or drink alcohol. These increase irritation in your stomach and can increase the time it will take for your ulcer to heal.. If you get black, tarry stools or vomit up what looks like coffee grounds, call your doctor or health care professional right away. You may have a bleeding ulcer.. ...
Tell your doctor or health care professional if your pain does not start to get better or gets worse. You may need to take this medicine for several days before your symptoms get better. Finish the full course of tablets prescribed by your doctor or health care professional even if you feel better.. Do not take with aspirin, ibuprofen, or other antiinflammatory medicines unless directed to do so by your health care professional. These can make your condition worse.. Do not smoke cigarettes or drink alcohol. These increase irritation in your stomach and can increase the time it will take for your ulcer to heal.. If you get black, tarry stools or vomit up what looks like coffee grounds, call your doctor or health care professional right away. You may have a bleeding ulcer.. ...
Tell your doctor or health care professional if your pain does not start to get better or gets worse. You may need to take this medicine for several days before your symptoms get better. Finish the full course of tablets prescribed by your doctor or health care professional even if you feel better.. Do not take with aspirin, ibuprofen, or other antiinflammatory medicines unless directed to do so by your health care professional. These can make your condition worse.. Do not smoke cigarettes or drink alcohol. These increase irritation in your stomach and can increase the time it will take for your ulcer to heal.. If you get black, tarry stools or vomit up what looks like coffee grounds, call your doctor or health care professional right away. You may have a bleeding ulcer.. ...
Revision date indicates the date the MSDS or SDS was last revised. MSDS / SDS are dated when they are originally issued AND when any significant change has been made to the chemical compound or research has revealed a health or physical hazard different from what was originally stated. Additional information regarding MSDS / SDS is available at https://www.osha.gov ...
This medication is typically used 4 times a day. However, your doctor or pharmacist may have suggested a different schedule that is more appropriate for you. Take it regularly and continuously to maintain its beneficial effects. Your doctor has prescribed this medication for a specific period of time. Take it for the entire time prescribed in order to achieve the medications full benefit, even if you begin to feel better sooner. Avoid using or consuming substances that may irritate your stomach, such as: ...
The drug brand named Ulcenon contains generic salt - Cimetidine and is manufactured by EMS Industria Farmaceutica.Ulcenon is mainly associated with symptoms and indications - The International Classification of Diseases (ICD) - A02BA01 - Cimetidine ...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
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FDA Drug Safety Announcement - The U.S. Food and Drug Administration (FDA) is warning that the insomnia drug Lunesta (eszopiclone) can cause next-day impairment of driving and other activities that require alertness. As a result, we have decreased the recommended starting dose of Lunesta to 1 mg at bedtime. Health care professionals should follow the new dosing recommendations when starting patients on Lunesta. Patients should continue taking their prescribed dose of Lunesta and contact their health care professionals to ask about the most appropriate dose for them.. A study of Lunesta found that the previously recommended dose of 3 mg can cause impairment to driving skills, memory, and coordination that can last more than 11 hours after receiving an evening dose (see Data Summary). Despite these driving and other problems, patients were often unaware they were impaired. The new lower recommended starting dose of 1 mg at bedtime will result in less drug in the blood the next day.. Women and men ...
last night i took 600mg tagamet 45 min prior to takin 12mg klonopin....i didnt notice many effects and partly attribute it to having eaten a very fatty chicken pasta alfredo last that night... my question is, does white grapefruit juice or tagamet (cimetidine), both CYP450 liver enzyme inhibitors, potentiate klonopin better/more effectively? thanks, appreciate educated answers as always
Multiple Choice Test mediMOCK 148 1) Cimetidine Choose 2 of the following options. a) lowers plasma crea
Pill with imprint 317 M is Green, Five-sided and has been identified as Cimetidine 300 mg. It is supplied by Mylan Pharmaceuticals Inc..
I am new here but need some advice please. Years ago I took Carafate with Tagamet...the dr had me dissolve Carafate in a little water to make like a slurry and...