Severe forms of chronic periodontitis affect up to 10% of adults. Tumour necrosis factor and lymphotoxin-alpha genes in the major histocompatibility complex are associated with severe periodontitis. Complement factor C4 is a nearby, polymorphic, functionally relevant gene region. Although associated with chronic mucosal infections, C4 deficiencies have not been assessed in adult periodontitis patients. We tested whether complement levels are systemically altered and C4 deficiencies associated with severe chronic periodontitis. In a case-control study, we analysed levels of plasma C3, and C4, serum classical pathway haemolytic activity, C4 allotypes and C4 gene numbers in 37 patients with severe chronic periodontitis and in 150 voluntary controls. Plasma levels of C3 were higher, and classical pathway haemolytic activity was lower in patients than in controls. Partial C4 gene deficiencies were more frequent in patients than in controls (odds ratio 2.4, 95% confidence interval 1.1-5.5, P = 0.032). ...
Additional file 6: Table S5. of Transcriptome sequencing of gingival biopsies from chronic periodontitis patients reveals novel gene expression and splicing patterns
Objective: This study was aimed at evaluating the occurrence of six periodontal pathogens in the subgingival plaque of patients with chronic periodontitis in Nigeria.. Methods: Forty-two subjects with chronic periodontitis participated in the cross-sectional study between June, 2015 and August, 2016. Subgingival plaque samples from one site of ?3mm depth (gingivitis) and another site with the greatest depth of ?4mm (periodontitis) respectively were collected from each subject. Culture and PCR assay using 16S rRNA species-specific primers, were performed. Fishers exact test was used for statistical analysis.. Results: Majority (73.8%) of the subjects were positive for at least one of the organisms. Culture was positive for P. gingivalis, F. nucleatum and P. intermedia in 23.8%, 14.3% and 14.3% of the subjects respectively in sites of ?3mm and at 33.3%, 23.8% and 33.3% respectively in sites of ?4mm. PCR was able to detect all six periodontopathogens in sites of ?4mm, with A. ...
This review examines literature data concerning the bacterial findings in chronic periodontitis depending on pocket depth, and presents the latest published information on the presence of proinflammatory factors in periodontal environment. It has been found that chronic periodontitis affects as much …
Eventbrite - The Dental Implant Clinic presents SWHATS - Supportive Periodontal Therapy. An evidence-based approach - Wednesday, 13 September 2017 at The Dental Implant Clinic, Bath, England. Find event and ticket information.
|i|Background/Purpose. |/i|Chronic periodontitis is an inflammatory disease of gums that causes loss of supporting structures of teeth, that is, gingiva, periodontal ligament, cementum, and alveolar bone. Levels of various cytokines in the serum, gingival tissues, and gingival crevicular fluid in patients with chronic periodontitis have been studied, but limited data are available on the level of cytokines in saliva. Therefore, a study was designed to determine levels of salivary IL-6 and IL-17 in patients with calculus associated chronic periodontitis.|i| Materials and Methods.|/i| It was a comparative, cross-sectional study that is comprised of 41 healthy controls and 41 calculus associated chronic periodontitis patients (CP patients). According to the degree of attachment loss, CP patients were subcategorized as mild (CAL 1-2 mm), moderate (CAL 3-4 mm), and severe (CAL > 5 mm) forms of periodontitis. Salivary levels of IL-6 and IL-17 were determined using enzyme-linked
Introduction: Chronic periodontitis (CP) is an infectious disease resulting in the inflammation of the supportive structures of teeth, which leads to loss of attachment and bone, and eventually tooth loss if left untreated. Genetic polymorphisms in the proinflammatory cytokine, interleukin-1 (IL-1A and IL-1B) isoforms have been associated with CP in Caucasians, Asians and Arabs but little is known about their role in Africans. Therefore, the aim of this study was to resolve the association between genetic polymorphisms in IL-1A and IL-1B isoforms and chronic periodontitis in two Kenyan coastal communities, the Taita and the Swahili. Objectives: 1) To determine the association between socio-demographic characteristics, clinical features and CP amongst cases and controls in both ethnic groups. 2) To determine the severity of CP in both ethnic groups. 3) To determine the distribution of interleukin-1 genotype polymorphisms of IL-1Band IL-1A in both ethnic groups. 4) To evaluate the association ...
Methods: Forty chronic periodontitis (CP) subjects with hyperlipidaemia (CP/HPL group), 40 systemically healthy CP subjects (CP group) and 20 systemically and periodontally healthy subjects (control group) were enrolled. The clinical periodontal parameters, the serum concentrations of Lp-PLA2, lipid profiles including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c) and white blood cell (WBC) counts were determined and compared between different groups. Linear regression analysis was performed to identify the contributing factors of Lp-PLA2 ...
Schätzle, M; Löe, H; Lang, N P; Bürgin, W; Anerud, A; Boysen, H (2004). The clinical course of chronic periodontitis. Journal of Clinical Periodontology, 31(12):1122-1127.. Schätzle, M; Löe, H; Bürgin, W; Anerud, A; Boysen, H; Lang, N P (2003). Clinical course of chronic periodontitis. I. Role of gingivitis. Journal of Clinical Periodontology, 30(10):887-901.. Heitz-Mayfield, L J A; Schätzle, M; Löe, H; Bürgin, W; Anerud, A; Boysen, H; Lang, N P (2003). Clinical course of chronic periodontitis. II. Incidence, characteristics and time of occurrence of the initial periodontal lesion. Journal of Clinical Periodontology, 30(10):902-908.. Schätzle, M; Löe, H; Lang, N P; Heitz-Mayfield, L J A; Bürgin, W; Anerud, A; Boysen, H (2003). Clinical course of chronic periodontitis. III. Patterns, variations and risks of attachment loss. Journal of Clinical Periodontology, 30(10):909-918.. Schätzle, M; Lang, N P; Anerud, A; Boysen, H; Bürgin, W; Löe, H (2001). The influence of margins of ...
This network meta-analysis complements a review undertaken for the American Dental Associations Guideline on nonsurgical treatment of chronic periodontitis
Histopathological Features of Dental Pulp in Teeth with Different Levels of Chronic Periodontitis Severity. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
This study investigated genetic polymorphisms in Interleukin 10 (A-1082G, C-819T and C-592A) in 205 individuals from an admixed Brazilian population. A significantly increased risk of developing chronic periodontitis was observed in individuals with low IL-10 production and Amerindian ancestry. These results suggest that the polymorphisms A-1082G, C-819T, and C-592A, which are associated with ance...
OBJECTIVE The aim of this study was to assess the effect of adjunctive photodynamic therapy (PDT) (using 810 nm diode laser and Indocyanine green as photosensitizer) in chronic periodontitis. MATERIALS AND METHODS Patients with untreated chronic periodontitis were included. Treatment was done according to a split mouth design. All sites received periodontal treatment comprising scaling and root-planing (SRP). Test group were additionally treated with PDT. Plaque Index (PI), Gingival Index (GI), Probing Pocket Depth (PPD) and Relative Attachment Level (RAL) were evaluated at baseline, 1 month and 3 months. RESULTS Mean baseline values for PI, GI, PPD and RAL were not different in the test group and control group. Statistical significant difference in PPD and RAL, 3 months after treatment was seen in test group as compared to the control group. CONCLUSIONS In patients with chronic periodontitis, clinical outcomes of conventional SRP can be improved by adjunctive PDT.
T his i nvestigation c ompared g ingival c revicular fl uid (GCF) interleukin-1β (IL-1β) concentrations in periodontitis patients subjected to a strict supragingival biofilm control (Supra) for 6 months. Never-smokers (23) and smokers (n = 20; 19.6 ± 11.8 cigarettes/day) moderate-to-severe chronic periodontitis patients underwent a 6 months period of supragingival control with weekly recall visits. Periodontal probing depth (PPD), bleeding on probing (BOP) and GCF samples (from different PPD category sites: 3-5 mm and 6-10 mm) were obtained at the baseline, 30, and 180 days. IL-1β was assessed by enzyme-linked immunosorbent assay. Generalized estimating equations were used to fit prediction models of IL-1β changes, considering the dependence between the examinations, and using only data from experimental sites. Overall IL-1β concentrations decreased from 3.2 pg/μL to 1.9 pg/μL. Higher baseline IL-1β concentrations were associated with higher baseline PPD values in both groups. There ...
Aim This study evaluated whether diabetes modulates gene expression [interleukin (IL)-1 beta, IL-1ra, IL-6, IL-8, IL-10; tumor necrosis factor (TNF)-alpha; interferon (IFN)-gamma, receptor activator of NF-kappa B ligand (RANKL) and osteoprotegerin (OPG)] in sites with periodontitis. Materials and Methods Gingival biopsies were harvested and divided into three groups - Control group: systemically and periodontally healthy subjects (n = 10); Periodontitis group: systemically healthy subjects diagnosed with chronic periodontitis (n = 20); Diabetes group: type 1 diabetic subjects, diagnosed with chronic periodontitis (n = 20). Total RNA was obtained and analyzed by quantitative polymerase chain reaction. Results Data analysis demonstrated that, except for OPG, mRNA levels for all factors were increased by inflammation (P , 0.001). Interleukin-1 beta, IL-1ra, IL-6, IL-8, IFN-gamma, and RANKL mRNA levels were higher in the diabetic group when compared with the control non-periodontitis group (P , ...
Many studies have looked at the link between periodontitis and heart disease. While there is not enough evidence to say that periodontitis causes hear
OBJECTIVE: To determine the percentage of the blood flow signal that is derived from dental pulp when recording from exposed dentine in a human premolar. DESIGN: Recordings were made from 7 healthy teeth in 5 subjects (aged 22-33 yr.) with a laser Doppler flow meter (Periflux 4001) using either a red (635 nm) or an infrared (780 nm) laser. After exposing dentine above the buccal pulpal horn (cavity diam. 1.6 mm, depth 3 mm) and isolating the crown with opaque rubber dam, blood flow was recorded alternately with infrared or red light from the exposed dentine under four conditions: before and after injecting local anaesthetic (3% Mepivacaine without vasoconstrictor) (LA) over the apex of the root of the tooth; after exposing the pulp by cutting a buccal, class V cavity in the tooth; and after sectioning the coronal pulp transversely through the exposure ...
This multi-center study of the Laser Assisted New Attachment Procedure (LANAP protocol) using the FR Pulsed Nd:YAG laser compared to Scaling and Root Planing alone, Modified Widman Flap (MWF) surgery, and Coronal Debridement (CD) alone will utilize a single-blind, four-quadrant split-mouth design with MWF as the positive control, CD as a weak positive control and SRP as the standard treatment control. The study will be conducted at three (3) to five (5) investigational centers. Subjects will receive the Laser Assisted New Attachment Procedure (LANAP protocol) using the pulsed FR Nd:YAG laser, Scaling and Root Planing alone, Modified Widman Flap surgery, and Coronal Debridement alone each in one quadrant of their mouth at Baseline. Treatment modalities are randomly assigned to quadrants at the time of treatment.. Efficacy evaluations, including clinical attachment level (CAL), probing depth (PD), and bleeding on probing (BOP) will be performed at Baseline, month 6, and month 12 using a Florida ...
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
Egea, J., Fabregat, I., Frapart, Y. M., Ghezzi, P., Görlach, A., Kietzmann, T., Kubaichuk, K., Knaus, U. G., Lopez, M. G., Olaso-Gonzalez, G., Petry, A., Schulz, R., Vina, J., Winyard, P., Abbas, K., Ademowo, S., Afonso, C. B., Andreadou, I., Antelmann, H., Antunes, F., Aslan, M., Bachschmid, M. M., Barbosa, R. M., Belousov, V., Berndt, C., Bernlohr, D., Bertrán, E., Bindoli, A., Bottari, S. P., Brito, P. M., Carrara, G., Casas, A. I., Chatzi, A., Chondrogianni, N., Conrad, M., Cooke, M. S., Costa, J. G., Cuadrado, A., My-Chan Dang, P., De Smet, B., Debelec-butuner, B., Dias, I., Dunn, J. D., Edson, A. J., El Assar, M., El-Benna, J., Ferdinandy, P., Fernandes, A. S., Fladmark, K. E., Förstermann, U., Giniatullin, R., Giricz, Z., Görbe, A., Griffiths, H., Hampl, V., Hanf, A., Herget, J., Hernansanz-Agustín, P., Hillion, M., Huang, J., Ilikay, S., Jansen-Dürr, P., Jaquet, V., Joles, J. A., Kalyanaraman, B., Kaminskyy, D., Karbaschi, M., Kleanthous, M., Klotz, L-O., Korac, B., Korkmaz, K. S., ...
The University of Melbourne has been working on a vaccine for chronic periodontitis for many years. It looks like they will begin clinical trials in 2018. The vaccine will target enzymes created by the bacteria p.gingivalis and will hopefully reduce the need for surgery or antibiotics to treat severe gum disease. This is especially exciting for patients who are more at risk, … ...
The case shown here is of a 46 year-old female patient diagnosed with a severe generalised Chronic Periodontitis. The x-rays revealed the presence of several angular bony defects, known to progress quickly if left untreated, leading to tooth loss.. ...
Periodontal models with severe and chronic periodontitis in various stages. Bone loss receding gum disease model for hygiene calculus cleaning practice.
How to cite this article: Sahota J, Bakshi D, Kaur G, Singh D, Thakur A, Grover S. Estimation of Plasma Levels of Tumor Necrosis Factor-α, Interleukin-4 and 6 in Patients with Chronic Periodontitis and Type II Diabetes Mellitus. J Contemp Dent Pract 2018; 19 (2):166-169. ...
No.. I was not talking about that small bone like thing above the teethset. I was talking about proper teeth.. see on the left in the xray.. the teeth have lost bone support and appear to be placed in an empty socket! Advanced case of Chronic Periodontitis. Pyorrhoea for the layman. ...
Periodontitis is an endemic inflammatory disease caused by a mixed bacterial biofilm infection that is followed by destruction of tooth supporting tissues. Standard of care consists of lifelong mechanical removal of the biofilm. However, outcome is variable. According to recent EFP and AAP reviews, adjunctive antimicrobial therapy may be beneficial.However, bearing in mind that Colombia has reported the frequent presence of Enterobacteriaceae (Klebsiella and Enterobacter) in subgingival plaque of patients with chronic periodontitis, the response to treatment may be different.The enteric have shown resistance to amoxicillin, amoxicillin / clavulanate, metronidazole and tetracycline in studies conducted in the United States, Norway, Brazil and Colombia.Although the combination ciprofloxacin metronidazole has been recommended in the dental literature are not known publications that demonstrate its effectiveness against periodontopathogens and enteric present in subgingival plaque of subjects with ...
Background and objective:Gingival bleeding reduction in smokers has been associated with decreased blood vessel density. The mechanism of suppressive effect of cigarette smoking on blood vessel density is not precisely defined. The aim of this study was to evaluate the impact of smoking on angiogenesis by assessing mast cells density and VEGF expression in chronic periodontitis. Materials& Methods: 52 paraffin embedded block of gingiva tissues with periodontitis obtained from 30 nonsmokers and 22 smokers undergoing flap surgery were examined immunohistochemically for VEGF expression. Mast cell counts was completed on toluidine blue stained slides. Exposure to cigarette smoking was calculated by the number of packs × year. Patients were classified into 4 groups based on the number of smoked cigarettes. The correlation between VEGF expression and mast cell counts was evaluated and compared in nonsmokers and smokers. Results: The mean number of mast cells (p=0.004) and average value of VEGF expression (p
p,Background: Only a few studies have examined the association between periodontitis and glycated hemoglobin (HbA1c) levels in individuals without diabetes. The aim of this study is to compare HbA1c levels in individuals without diabetes and with and without periodontitis before and after non-surgical periodontal therapy. Methods: This comparative study was done on individuals without diabetes who were 35 to 65 years old. Group A consisted of 30 individuals without periodontitis, and group B consisted of 30 individuals with periodontitis. Body mass indices and clinical parameters, including oral hygiene indexsimplified (OHI-S) score, gingival index (GI), probing depth (PD), clinical attachment level (CAL), and HbA1c level, of all participants were recorded. All participants received non-surgical periodontal therapy (scaling and root planing). After 3 months, all participants were reexamined, and clinical parameters and HbA1c levels were evaluated and compared to baseline values. Results: There ...
Systemic infection and/or inflammation has been related with an increased risk of brain abscesses, cerebrovascular disease, cognitive impairment and other pathological states of the brain. Therefore, it is plausible, that a chronic infection and inflammation disease, such as periodontitis, may affect the central nervous system (CNS). Chronic periodontal disease is a condition that causes breakdown of the supporting tissues of the teeth, alveolar bone and soft tissues. Chronic periodontitis is a multifactorial disease caused by dental plaque composed of pathogenic bacteria that triggers the immune response in susceptible hosts. Oral pathogenic bacteria is a source of chronic infection that can induce local and peripheral production of pro-inflammatory cytokines such as IL-1ß, IL-6 and TNF- , inflammatory mediators, as well as bacterial products such as lipopolysaccaride endotoxin. Viruses, such as herpes and Epstein-Barr, can also be found in periodontal pockets. It is well established that oral ...
lub and colleagues in the 1980s, Golub and others further studied the influence of SDD on the host response on a molecular level.. In 1997, Golub and colleagues26 studied whether SDD administration to a population of patients with chronic periodontitis would reduce the amount of specific collagenases and bone-type collagen degradation fragments in gingival crevicular fluid (GCF). Their study design included SRP in 18 subjects with chronic periodontitis, 12 of which received an adjunctive treatment with 20mg bid doxycycline. Both groups were followed up for a period of two months. A significant reduction in neutrophil-type collagenase (MMP-8) and MMP-13, which is associated with bone resorption, as well as a significant (p,0.05) reduction in collagen degradation fragments, was observed. The authors acknowledged that for the first time, in human studies, a reduction of MMP activity was detected with concomitant reduction in levels of collagen degradation fragments.. In a more recent study Choi et ...
The outstanding performance of XO ODONTOSON 360 and XO ODONTOGAIN scalers was researched and confirmed in numerous scientific publications:. Periodontal treatment:. Drisko CH., Lewis LH. (1996) Ultrasonic instruments and antimicrobial agents in supportive periodontal treatment and retreatment of recurrent or refractory periodontitis. Periodontology 2000 12, 90-115.. Greenstein G. (1999) Povidone-iodines effects and role in the management of periodontal diseases: a review. Journal of Periodontology, 70(11), 1397-405.. Rosling B., Hellström MK., Ramberg P., Socransky SS., Lindhe J. (2001) The use of PVP-iodine as an adjunct to non-surgical treatment of chronic periodontitis. Journal of Clinical Periodontology, 28(11), 1023-31.. Serino, G., Rosling, B., Ramberg, P., Socransky, S. S. & Lindhe, J. (2001) Initial outcome and long-term effect of surgical and non-surgical treatment of advanced periodontal disease. Journal of Clinical Periodontology, 28(10), 910-916.. Slots J., Jorgensen MG. (2000) ...
Chronic periodontitis and DM have close relationship, especially in DM patient with uncontrolled hyperglycemia [13]. In uncontrolled DM patient, periodontitis is more severe in its prevalence and severity [14]. Likewise, periodontitis also affects DM as periodontitis itself can worsen glycemic control of DM patient [15]. Mechanism of this interrelations between periodontitis and DM is still not fully understood, but the receptor activator of nuclear factor-κB (RANK)/RANK ligand/osteoprotegerin axis, receptor for advanced glycation end products pathway and oxidative stress mechanism are reported to be related in recent research [16].. DM is a very frequent metabolic disorder characterized by the presence of chronic hyperglycemia because of low levels of both insulin secretion and its action [14]. T1DM is a type of juvenile diabetes that accounts for more than 85% of all diabetes patients under 20 years of age, accounting for 5%-10% of the worlds DM population. T2DM accounts for 90% of diabetes ...
Amaliya, Timmerman MF, Abbas F, Loos BG, Van der Weijden GA, Van Winkelhoff AJ, et al. Java project on periodontal diseases: the relationship between vitamin C and the severity of periodontitis. J Clin Periodontol. 2007 Apr;34(4):299-304.. Boggess KA; Society for Maternal-Fetal Medicine Publications Committee. Maternal oral health in pregnancy. Obstet Gynecol. 2008 Apr;111(4):976-86.. Eberhard J, Jepsen S, Jervøe-Storm PM, Needleman I, Worthington HV. Full-mouth disinfection for the treatment of adult chronic periodontitis. Cochrane Database Syst Rev. 2008 Jan 23;(1):CD004622.. Eberhard J, Jervøe-Storm PM, Needleman I, Worthington H, Jepsen S. Full-mouth treatment concepts for chronic periodontitis: a systematic review. J Clin Periodontol. 2008 Jul;35(7):591-604. Epub 2008 May 21.. Friedewald VE, Kornman KS, Beck JD, Genco R, Goldfine A, Libby P, et al. The American Journal of Cardiology and Journal of Periodontology Editors Consensus: periodontitis and atherosclerotic cardiovascular disease. ...
We report here that the leptomeningeal cells transduce inflammatory signals from peripheral macrophages to brain-resident microglia in response to Porphyromonas gingivalis (P.g.) LPS. The expression of Toll-like receptor 2 (TLR2), TLR4, TNF- α , and inducible NO synthase was mainly detected in the gingival macrophages of chronic periodontitis patients. In in vitro studies, P.g. LPS induced the secretion of TNF- α and IL-1 β from THP-1 human monocyte-like cell line and RAW264.7 mouse macrophages. Surprisingly, the mean mRNA levels of TNF- α and IL-1 β in leptomeningeal cells after treatment with the conditioned medium from P.g. LPS-stimulated RAW264.7 macrophages were significantly higher than those after treatment with P.g. LPS alone. Furthermore, the mean mRNA levels of TNF- α and IL-1 β in microglia after treatment with the conditioned medium from P.g. LPS-stimulated leptomeningeal cells were significantly higher than those after P.g. LPS alone. These observations suggest that ...
We report here that the leptomeningeal cells transduce inflammatory signals from peripheral macrophages to brain-resident microglia in response to Porphyromonas gingivalis (P.g.) LPS. The expression of Toll-like receptor 2 (TLR2), TLR4, TNF- α , and inducible NO synthase was mainly detected in the gingival macrophages of chronic periodontitis patients. In in vitro studies, P.g. LPS induced the secretion of TNF- α and IL-1 β from THP-1 human monocyte-like cell line and RAW264.7 mouse macrophages. Surprisingly, the mean mRNA levels of TNF- α and IL-1 β in leptomeningeal cells after treatment with the conditioned medium from P.g. LPS-stimulated RAW264.7 macrophages were significantly higher than those after treatment with P.g. LPS alone. Furthermore, the mean mRNA levels of TNF- α and IL-1 β in microglia after treatment with the conditioned medium from P.g. LPS-stimulated leptomeningeal cells were significantly higher than those after P.g. LPS alone. These observations suggest that ...
Periodontitis is a chronic inflammatory disease of tooth supporting tissues resulting in periodontal tissue destruction, which may ultimately lead to tooth loss. The pathogenetic mechanisms of periodontitis are not fully elucidated. The disease is characterized by continuous leukocyte infiltration, likely mediated by local cytokine and chemokine production. There are no serologic biomarkers for the diagnosis of periodontitis, which is based solely on the degree of local tissue destruction. The aim of this study was to identify serological biomarkers for periodontitis by analyzing a spectrum of cytokines in serum from subjects with and without periodontitis and also to investigate if the detected cytokines were expressed by gingival fibroblasts, the most abundant cell type in the inflamed periodontium. We mapped serum cytokine and chemokine levels from periodontitis subjects and healthy controls. We used multivariate partial least squares (PLS) modeling and identified monocyte chemoattractant ...
Platelets from untreated periodontitis patients are hyper-reactive and form more platelet-leukocyte complexes compared to cells from individuals without periodontitis. It is not known whether the improvement of the periodontal condition achievable by therapy has beneficial effects on the platelet function. We aimed to assess the effects of periodontal therapy on platelet reactivity. Patients with periodontitis (n = 25) but unaffected by any other medical condition or medication were included and donated blood before and after periodontal therapy. Reactivity to ADP or oral bacteria was assessed by flow cytometric analysis of membrane markers (binding of PAC-1, P-selectin, CD63) and platelet-leukocyte complex formation. Reactivity values were expressed as ratio between the stimulated and unstimulated sample. Plasma levels of soluble (s) P-selectin were determined by enzyme-linked immunosorbent assay (ELISA). Binding of PAC-1, the expression of P-selectin and CD63 in response to the oral bacterium P.
Periodontitis: Causes, Risk Factors, and Treatment Periodontitis is the inflammation in the teeth and supporting gums. It is a serious gum disease that can result in gum damage and can even destroy the jaw bone. Periodontitis is caused by certain periodontal bacteria in the form of dental plaque. A layer of bacteria and food debris gets build-up on areas that are hard to reach and hence results in periodontitis. Periodontitis always begins with inflammation of the gums commonly called gingivitis. Sometimes it results in bleeding when you brush your teeth. You might notice a discolored bacterial layer on your teeth, if left untreated may result in chronic diseases or tooth loss. Periodontal Treatment: The key to eliminating the periodontitis is by triggering the diseases through diagnosis. As the disease progress, the teeth can be damaged. Hence, it is necessary that the disease should be treated as early as possible. It is important to remove plaque and associated bacteria to resume dental ...
Raghavendra Reddy Nagati, M. Ragul, Nabeeh A. AlQahtani, K. S. Ravi, S. Tikare, Mohan Kumar Pasupuleti. Clinical Effectiveness of Gingival Depigmentation Using Conventional Surgical Scrapping and Diode Laser Technique: A Quasi-Experimental Study. Global Journal of Health Science. 2017; 9(3): 296-303. Nabeeh A. AlQahtani, Betsy J, Angelin D, Baiju, KV. Prevalence of chronic periodontitis and its risk determinants among female patients in Aseer region, Saudi Arabia. J. Taibah Univ. Med. Sci. 2017; 12(3): 241-248.
We found no significant differences in ranges of motion or complications sildenafil ratiopharm kaufen ohne rezept between the 2 groups. The maximum specific rate of product formation was estimated to be 125.7 g total volatile fatty acid/g biomass/day.. chabaudi, hemoglobin digestion occurs in two viagra boots ways: micropinocytosis and cytostomal phagocytosis. The potential for using risk models in future lung cancer screening trials.. Reclaiming wellness-living with bodily problems, as narrated by men with advanced prostate cancer. Age differences in FMRI adaptation for sound identity and location. Responses of semicircular canal and otolith afferents to small angle static head tilts in the gerbil.. Our preliminary results indicate microRNAs should be considered viagra alternatives and evaluated in the etiology of autism. Chorionic villi from first trimester pregnancy terminations showed strong expression of BCL-2 and EGF-R protein. Here we test the hypothesis that TRPC5 is such an additional ...
During the past decade, the use of osseointegrated implants as a foundation for prosthetic replacement of missing teeth has become highly predictable and successful. SPT(Supportive Periodontal Therapy) identified as regular visits to the therapist for periodontal control and maintenance in a well-organized scheme, the number of appointments per year following a pre-designed subject-tooth/implant-site risk assessment method. Peri-implant disease was a frequent finding in subjects having natural healthy dentition and in subjects without periodontitis. Supportive periodontal program were found to be strongly related to implant survival. This study demonstrates that regular maintenance reduces the risk for peri-implant inflammation significantly as compared with irregular maintenance. This underlines the value of the SPT in enhancing the long-term outcomes of implant therapy, particularly in subjects affected by periodontitis, in order to control reinfection and limit biological complications. It is ...
He said the discovery stage used a German sample with aggressive periodontitis (717 cases vs 4,213 controls) and the CARDIoGRAMplusC4D CAD meta-analysis dataset, which included 60,801 cases and 123,504 controls. Replication was performed in an independent genome-wide association study (GWAS) meta-analysis dataset consisting of patients with either aggressive periodontitis or with chronic periodontitis from Germany, Austria, The Netherlands, and the United States (4,423 cases vs 6,219 controls).. Researchers identified a variant in the promoter region of the gene VAMP8 (a promoter regulates the activity of a gene in response to other stimuli) to be significantly more frequent in CAD and periodontitis cases than in healthy controls, indicating the involvement of this gene in the aetiology of both diseases.. "VAMP8 is of special interest, because it is involved in the import and export of molecules and other substances into and out of the cells (acting as a sort of door)," Dr. Schäfer said. "It is ...
Background: Interpretation of risk for periodontitis is critical for treatment planning. How periodontists assess risk for periodontitis is unclear. Purpose: To study (1) what factors periodontists use when assessing the risks for worsening periodontal conditions anticipating that no treatment would be provided, and (2) if risk assessment is consistent and independent of specialty background training. Material and Methods: Medical history, clinical dental data, full-mouth intra-oral radiographs, and slide pictures were obtained from each of 51 subjects, and the information was provided to 23 examiners. Results: The mean age of the study subjects was 51.5 years (SD±17.7, range 23-81), with 28 women included. In 10 of the subjects, only gingivitis was identified, while 22 subjects had advanced chronic periodontitis. Risk scores assigned for 2 and 4 years differed significantly between European- and US-trained periodontists (p < 0.001) and between graduate students in training and periodontists ...
Material and Method: 10 patients (7 female, 32 to 73 years of age) medicated with cyclosporine and/or calcium channel blocker received oral hygiene instruction, professional tooth cleaning followed by scaling and root planning of all 4 quadrants within 24 hours. Patients rinsed with 0.12% CHX solution and brushed with 1% CHX gel for the next 2 weeks. The clinical situation was re-evaluated approximately 4 months after FMD. After completion of FMD 8 patients were assigned to supportive periodontal therapy (SPT) and monitored for a mean of 24 months. Plaque control record (PCR), gingival bleeding index (GBI), pocket depth (PD) were recorded at baseline, re-evaluation and the last SPT visit. PD sites were stratified as follows: <= 4 mm, 5-6 mm and >= 7 mm ...
Author: press release. The bacteria that cause periodontitis, a disease affecting the tissues surrounding the teeth, seems to play a part also in the onset of pancreatic cancer, say the researchers at the University of Helsinki and the Helsinki University Hospital, Finland, and the Karolinska Institutet, Sweden.. The researchers have investigated the role of bacteria causing periodontitis, an inflammation of the tissues surrounding the teeth, in the development of oral cancers and certain other cancers, as well as the link between periodontitis and cancer mortality on the population level.. The study, published in the British Journal of Cancer, has for the first time proven the existence of a mechanism on the molecular level through which the bacteria associated with periodontitis, Treponema denticola (Td), may also have an effect on the onset of cancer. Researchers found that the primary virulence factor of the Td bacteria, the Td-CTLP proteinase (an enzyme), occurs also in malignant tumors of ...
... How may times have you seen a patient who simply never appears periodontally healthy in spite of all your efforts? It s far too easy to just dismiss this type of patient by rationalizing that this is simply their normal appearance. After all, that is how they always appear: boggy, edematous gingiva with a reddish hue, generalized light to moderate bleeding upon probing, and pockets in the 4-7 mm range. You may have root planed them quadrant by quadrant, tried some antibiotic therapy, put them on a chlorhexidine rinse, and had them return every three months for a prophylaxis. Yet in spite of those efforts, they still appear unhealthy. Welcome to the world of the refractory patient. The term, defined in the AAP s Parameter on Refractory Periodontitis, published in The Journal of Periodontology May Supplement 2000 (Volume 71, No. 71), refers to destructive periodontal diseases in patients who, when longitudinally monitored, demonstrate additional ...
The association between diagnosed periodontitis, a common chronic oral infection, and metabolic symptoms continues to be reported. threat of CHD [5]. Great degrees of Immunoglobulin G (IgG) antibody titers to may also be seen in periodontitis sufferers [6]. With this association using the chronic inflammatory response, it really is postulated that periodontitis might improve atherosclerosis in sufferers with MS, resulting in early CHD. Great degrees of C-reactive proteins (CRP), a powerful and delicate systemic marker of irritation, have already been reported in sufferers with MS [7,8]. Many research have got reported raised CRP levels in periodontitis individuals [9C11] also. Therefore, the function of CRP must be further examined by taking into consideration the effects of various other factors, such as for example oral attacks that could enhance CRP levels and keep maintaining a low-grade systemic irritation. The antibody response to periodontopathic amounts and bacteria of CRP could possibly ...
By Borrell, Luisa N Burt, Brian A; Neighbors, Harold W; Taylor, George W Objectives. We assessed the prevalences of periodontitis by education and income levels among US adults with data from the third National Health and Nutrition Examination Survey. Methods. The study was limited to non-Hispanic Blacks, Mexican Americans, and non- Hispanic Whites 50 years of age or older with a complete periodontal assessment during the dental examination. Results. Blacks with higher education and income levels had a significantly higher prevalence of periodontitis than their White and Mexican-American counterparts. The relationship between income level and periodontitis was modified by race/ethnicity. High-income Blacks exhibited a higher prevalence of periodontitis than did low- income Blacks and high-income Whites. Conclusions. Our findings call attention to the importance of recognizing socioeconomic status-related health differences across racial/ethnic groups within the social, political, and historical ...
In Europe, cirrhosis is responsible for 1-2% of all deaths and is the leading cause of liver transplantation.1,2 Periodontitis is a bacterially induced inflammatory disease that affects the supporting tissues of the teeth, characterised by the deepening of periodontal pockets due to loss of connective tissue attachment and bone. Untreated, periodontitis may result in tooth loss. Periodontitis is prevalent in the adult population, with over 35% having periodontitis and 10-15% having severe forms of the disease.3,4 Several studies have assessed the association between periodontitis and cardiovascular diseases, cirrhosis, chronic kidney disease, diabetes mellitus, and respiratory diseases, and an increasing number of studies have suggested that periodontitis may affect the course of systemic diseases.5 Poor oral health and periodontitis are very frequent in patients with cirrhosis.5 In addition, studies have suggested that periodontitis is involved in the progression of liver diseases, and that it ...
Introduction: Propolis is one of the few natural remedies that have maintained its popularity over a long period of time. It s a natural antibiotic is a resinous substance that honey bees collect from tree buds, sap flow, shrubs and other botanic sources. Propolis is a subject of recent research in dentistry, since there is some evidence that propolis may actively protect against oral disease due to its antimicrobial, anti-inflammatory and host modulatory properties. The present research was undertaken to test the efficacy of propolis as an adjunct to SRP on clinical Parameters and cytokine levels in patients with chronic periodontitis. Methodology: 15 patients diagnosed with chronic generalized periodontitis were included in the study. Two quadrants with maximum number of sites with PPD measuring ≥ 6mm were selected from each patient. The clinical parameters like MGI, BOP, PPD, CAL were recorded for the selected quadrants in all teeth excluding third molars. 3 litre of GCF were collected from ...