Read "Chromosome substitution strains: gene discovery, functional analysis, and systems studies, Mammalian Genome" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Read "Identification of a tandem duplicated array in the Rhox α locus on mouse chromosome X, Mammalian Genome" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
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The Genetics Society of America (GSA), founded in 1931, is the professional membership organization for scientific researchers and educators in the field of genetics. Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level.. Online ISSN: 1943-2631. ...
The CSS Resource comprises 22 mouse lines, each homozygous for a single A/J chromosome (Chr 1-19, X or Y and mitochondria) on a genetic background that is otherwise C57BL/J that were generated by Dr. Joseph Nadeau (Case Western Reserve University) and his colleagues. The CSS mice are available from The Jackson Laboratories. However, to save time and money, the MGH CSS Resource maintains CSS breeding colonies that are housed in the Simches-8 barrier facility, adjacent to a procedure room that will have equipment for basic standardized phenotyping, including behavioral and metabolic measurements. ...
The host genetic factors affecting susceptibility to disseminated candidiasis are incompletely defined. Peltz et al. (p. 4472-4479) used a next-generation computational genetic mapping program to identify genetic factors affecting inbred strain survival after disseminated candidiasis. Their analysis indicated that genetic variation within early classical complement pathway components (C1q, C1r, and C1s) affected survival. This result was verified by demonstrating that serum C1 binding to Candida albicans was strongly affected by C1rs alleles, as was survival in chromosome substitution strains. A combinatorial, conditional genetic model, involving an interaction between the C5 and C1r/s alleles, accurately predicted survival after disseminated candidiasis. Beyond its potential applicability to infectious diseases, this combinatorial genetic model could provide insight into the genetic architecture for susceptibility to autoimmune and neurodegenerative diseases. ...
BACKGROUND: Complex etiology and pathogenesis of pathophysiological components of the cardio-metabolic syndrome have been demonstrated in humans and animal models. METHODOLOGY/PRINCIPAL FINDINGS: We have generated extensive physiological, genetic and genome-wide gene expression profiles in a congenic strain of the spontaneously diabetic Goto-Kakizaki (GK) rat containing a large region (110 cM, 170 Mb) of rat chromosome 1 (RNO1), which covers diabetes and obesity quantitative trait loci (QTL), introgressed onto the genetic background of the normoglycaemic Brown Norway (BN) strain. This novel disease model, which by the length of the congenic region closely mirrors the situation of a chromosome substitution strain, exhibits a wide range of abnormalities directly relevant to components of the cardio-metabolic syndrome and diabetes complications, including hyperglycaemia, hyperinsulinaemia, enhanced insulin secretion both in vivo and in vitro, insulin resistance, hypertriglyceridemia and altered pancreatic
Salicylic acid (SA) is a phytohormone required for a full resistance against some pathogens in Arabidopsis, and NPR1 (Non-Expressor of Pathogenesis Related Genes 1) is the only gene with a strong effect on resistance induced by SA which has been described. There can be additional components of SA perception that escape the traditional approach of mutagenesis. An alternative to that approach is searching in the natural variation of Arabidopsis. Different methods of analyzing the variation between ecotypes have been tried and it has been found that measuring the growth of a virulent isolate of Pseudomonas syringae after the exogenous application of SA is the most effective one. Two ecotypes, Edi-0 and Stw-0, have been crossed, and their F2 has been studied. There are two significant quantitative trait loci (QTLs) in this population, and there is one QTL in each one of the existing mapping populations Col-4 ¿ Laer-0 and Laer-0 ¿ No-0. They have different characteristics: while one QTL is only ...
Each QTL identified in the crosses of inbred mice generally spans a large genomic distance, sometimes almost an entire chromosome. In complex phenotypes such as atherosclerosis, where a large number of genes are involved, transferring a target region onto an inbred background and creating congenic line is a powerful step toward identifying causative genes. Here we have analyzed the effect of the atherosclerosis QTL Aath4 by establishing a congenic line (Aath4aDBA/DBA), where the 5′ region of DBA Aath4 was backcrossed onto a 129S6-Apoe−/− background. As expected, the resulting Aath4aDBA/DBA males had significantly larger plaques, and macrophages isolated from these mice exhibited reduced efferocytosis as a consequence of allele-specific decrease in MERTK expression. Together, our results provide strong evidence that the increased susceptibility to atherosclerosis determined by the DBA allele of Aath4 is, at least in part, due to decreased MERTK expression.. MERTK is known to play a ...
Congenic strains are produced by transferring the transgene/KO allele to a new genetic background strain that is more appropriate for phenotypic analysis. The APF offer a speed congenics service that can establish a congenic strain within 18 months.
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The Ly-6 locus on mouse chromosome 15 encodes a family of 10-12 kDa proteins that are linked to the cell surface by a glycosylphosphatidyl-inositol anchor and have cell signaling and cell adhesion properties. Expression of Ly-6 proteins is tightly regulated during development; these proteins continu.... Full description. ...
Domestic horses next to river, Equus caballus, Hustain Nuruu National Park by Danita Delimont - Buy Domestic horses next to river, Equus caballus, Hustain Nuruu National Park as Poster by Danit...
Autoimmune type 1 diabetes (T1D) in humans and NOD mice results from interactions between multiple susceptibility genes (termed Idd) located within and outside the MHC. Despite sharing ∼88% of their genome with NOD mice, including the H2(g7) MHC haplotype and other important Idd genes, the closely related nonobese resistant (NOR) strain fails to develop T1D because of resistance alleles in residual genomic regions derived from C57BLKS mice mapping to chromosomes (Chr.) 1, 2, and 4. We previously produced a NOD background strain with a greatly decreased incidence of T1D as the result of a NOR-derived 44.31-Mb congenic region on distal Chr. 4 containing disease-resistance alleles that decrease the pathogenic activity of autoreactive B and CD4 T cells. In this study, a series of subcongenic strains for the NOR-derived Chr. 4 region was used to significantly refine genetic loci regulating diabetogenic B and CD4 T cell activity. Analyses of these subcongenic strains revealed the presence of at least two
Information on endogenous retroviruses fixed in the horse (Equus caballus) genome is scarce. The recent availability of a draft sequence of the horse genome enables the detection of such integrated viruses by similarity search. Using translated nucleotide fragments from gamma-, beta-, and delta-retroviral genera for initial searches, a full-length beta-retrovirus genome was retrieved from a horse chromosome 5 contig. The provirus, tentatively named EqERV-beta1 (for the first equine endogenous beta-retrovirus), was 10434 nucleotide (nt) in length with the usual retroviral genome structure of 5LTR-gag-pro-pol-env-3LTR. The LTRs were 1361 nt long, and differed approximately 1% from each other, suggestive of a relatively recent integration. Coding sequences for gag, pro and pol were present in three different reading-frames, as common for beta-retroviruses, and the reading frames were completely open, except that the env gene was interrupted by a single stopcodon. No reading frame was apparent ...
If you have a question about this talk, please contact Duncan Simpson.. Cohesins mediate sister chromatid cohesion, which is essential for chromosome segregation and postreplicative DNA repair. In addition, cohesins appear to regulate gene expression and enhancer-promoter interactions. These noncanonical functions remained unexplained because knowledge of cohesin-binding sites and functional interactors in metazoans was lacking. We show that the distribution of cohesins on mammalian chromosome arms is not driven by transcriptional activity. Instead, mammalian cohesins occupy a subset of DNase I hypersensitive sites, many of which contain sequence motifs resembling the consensus for CTCF , a DNA -binding protein with enhancer blocking function and boundary element activity. We find cohesins at most CTCF sites and show that CTCF is required for cohesin localization to these sites. Recruitment by CTCF suggests a rationale for noncanonical cohesin functions and, because CTCF binding is sensitive to ...
Accumulating evidence converges on the possibility that chromosomes interact with each other to regulate transcription in trans. To systematically explore the epigenetic dimension of such interactions, we devised a strategy termed circular chromosome conformation capture (4C). This approach involves …
Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More... ...
View Fig4/Fig4 Tg(ACTB-Fig4*I41T)705Mm/0 involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL: phenotypes, images, diseases, and references.
UW-Madison. We have used both classical genetics and sequence-based genomics in search of mouse modifiers of liver tumorigenesis. The dramatic 20-50-fold difference in tumor multiplicity between carcinogen-treated male C57BL/6 (B6) and C3H/HeJ (C3H) mice has been shown to map mainly to distal chromosome 1. We have bred congenic animals carrying 70cM of chromosome 1 from C3H on an otherwise B6 genetic background. Relative to B6 animals, these B6.C31 mice developed up to 14-fold more liver tumors. Analysis of recombinant animals carrying smaller portions of the C3H congenic region suggests the presence of two modifiers, one of which has a 5-8-fold effect on tumor multiplicity and lies in a 7 Mb region on distal chromosome 1. Ras mutations are more prevalent in C3H tumors than in B6. By comparing ras mutations in tumors from the B6.C31and parental strains, we have shown that the C3H alleles on distal chromosome 1 are not sufficient to recapitulate the high ras mutant frequency of C3H tumors, ...
A general experimental design that allows mapping of a quantitative trait locus (QTL) into a 1-cM interval is presented. The design consists of a series of strains, termed
As ruled by Opinion 2027 the scientific name of the Wild Horse can either be Equus ferus (as a species) or Equus ferus ferus (as a subspecies). It can not be Equus caballus ferus, as has erroneously been stated in Mammal Species of the World link: Equus caballus ferus (in error).. ...
Signals of dominance and submissiveness are central to conspecific communication in many species. For domestic animals, sensitivities to these signals in h
Abstract Book of the 33rd Conference of the International Society for Animal Genetics: P1000-P1041: Bioinformatics, statistical genetics, and genomic ...
The genome of a female Hereford cow has been sequenced by the Bovine Genome Sequencing and Analysis Consortium, a team of researchers led by the National Institutes of Health and the U.S. Department of Agriculture.[1] It is one of the largest genomes ever sequenced. The results, published in the journal Science on April 24, 2009,[2] are likely to have a major impact on livestock breeding.[3] They were obtained by more than 300 scientists in 25 countries after six years of effort.. The size of the bovine genome is 3 Gb (3 billion base pairs). It contains approximately 22,000 genes of which 14,000 are common to all mammalian species. Bovines share 80 percent of their genes with humans; cows are less similar to humans than rodents (humans and rodents belong to the clade of Supraprimates). They also have about 1,000 genes shared with dogs and rodents but not identified in humans.[4]. The charting of key DNA differences, also known as haplotypes, between several varieties of cattle could allow ...
Hypertension is a complex cardiovascular disease, and it is a daunting task to determine the degree to which each of a multitude of interrelated and environmentally influenced molecular and biochemical pathways contributes to the pathological rise in blood pressure. The overall purpose of the PhysGen studies, using chromosomal substitution techniques in the rat, is to expand our knowledge base related to the interrelationships among genes, environmental factors, and the regulatory systems that control blood pressure.. The specific purpose of the vascular protocol, described herein, was to uncover broad genomic regions that contain genes that may be involved in the regulation of vascular tone and the changes in vascular reactivity that occur in experimental models of hypertension when maintained on a high-salt diet. The summarized data presented here are derived from a first-pass high-throughput screening of several consomic strains of male rats and their parental strains. As such, these studies ...
100126308 Homo sapiens , 723941 Mus musculus , 100313266 Bos taurus , 100314080 Rattus norvegicus , 100315083 Equus caballus , 100315571 Macaca mulatta , 102464669 Ovis aries ...
The mule is an example of hybrid infertility; it is a hybrid between a male ass (Equus africanus) and a female horse (Equus caballus) and is somatically vigorous, but sterile. Photograph by Stephen Garton.. ...
This weekend, Lisa, a client of ours and a single mom, called sobbing, "Im so angry right now, I dont know what to do. I even hit my daughter- Im being so critical and I cant control myself!" I told her everything would be OK and to take a deep breath: she did. She continued, "I was outside of D.C.…. ...
The objective of this study was to confirm a quantitative trait locus for milk production described in a previous study on bovine chromosome 20 using an independent sample. A total of 1191 progeny tested bulls were analyzed for six microsatellite markers spanning bovine chromosome 20. Using multiple-marker regression, we obtained evidence (P , 0.5) for the presence of a quantitative traits locus in the same chromosomal region an affecting the same trait as described in the first study, therefore confirming genuine nature of this QTL.. ...
Deerhake, Marion Elizabeth, "Quantitative trait loci analysis of blood pressure in an eight intercross mouse study" (2008). Summer and Academic Year Student Reports. 2234 ...
Bovine chromosomes 2 (BTA2) and 5 (BTA5) of purebred, half-sib progeny sired by five Japanese black bulls were genotyped using microsatellite DNA markers. The data were subjected to linkage analysis for the detection and mapping of segregating quantitative trait loci (QTL) influencing live weight, average daily gain and body measurements at weaning. Probability coefficients of inheriting allele 1 or 2 from the sire at specific chromosomal intervals were computed. The phenotypic data on progeny were regressed on these probability coefficients in a within-common-parent regression analysis. Fixed effects of sex, parity and season of birth as well as age as a covariate, were fitted in a linear model to the phenotypic data and subsequently analysed using QTL Express by generating an F-statistic through permutation tests at chromosome-wide significance thresholds over 10, 000 iterations at 1 cM intervals. Highly significant (P<0.01) segregating QTL for body measurements were detected on BTA2 for hip
The objective of this study was to identify single-nucleotide polymorphisms using a bovine chromosome 14 high-density SNP panel after accounting for the effect of DGAT1. Linkage disequilibrium information and sire heterozygosity were used to select m
Cloning and characterization of highly polymorphic porcine microsatellites. The extension coat color locus and the loci for blood group O and tyrosine aminotransferase are on pig chromosome 6
TY - JOUR. T1 - Localization of the osteocalcin gene cluster on mouse Chromosome 3. AU - Desbois, C.. AU - Seldin, Michael F. AU - Karsenty, G.. PY - 1994/5. Y1 - 1994/5. UR - http://www.scopus.com/inward/record.url?scp=0028427906&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0028427906&partnerID=8YFLogxK. U2 - 10.1007/BF00389550. DO - 10.1007/BF00389550. M3 - Article. C2 - 7915557. AN - SCOPUS:0028427906. VL - 5. SP - 321. EP - 322. JO - Mammalian Genome. JF - Mammalian Genome. SN - 0938-8990. IS - 5. ER - ...
It has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens act through a variety of genotoxic and non-genotoxic mechanisms. Genotoxic carcinogens can attack biological macromolecules such as DNA and RNA either directly or indirectly through metabolism, resulting in the formation of adducts with these macromolecules. If DNA adducts escape cellular repair mechanisms and persist, they may lead to miscoding, resulting in permanent mutations. Non-genotoxic carcinogens act by the mechanisms such as induction of inflammation, immunosuppression, formation of reactive oxygen species, activation of receptors, and epigenetic silencing. Together, these genotoxic and non-genotoxic mechanisms can alter signal-transduction pathways that finally result in hypermutability, genomic instability, loss of proliferation control, and resistance to apoptosis - some of the ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Following the latest advice from Public Health England regarding the coronavirus, the Horniman has taken the difficult decision to close the Museum to the public from Wednesday 18 March until further notice.. Our 16.5 acres of beautiful Gardens remain open. The Garden toilets are now open with an increased cleaning regimen however the Sound Garden remains closed.. We will continue to update horniman.ac.uk and our social media channels whilst the Museum is closed and will advertise its reopening well in advance.. We are asking the public to adhere to social distancing guidance in the Gardens.. We thank you for your understanding and patience during this difficult period. Your ongoing support is so very important to us, and we will continue to share stories and objects from the collections throughout this time.. Read more about the closures.. ...
extracellular matrix, collagen V binding, heparin binding, extracellular matrix organization, positive regulation of cell-substrate adhesion
K00693 GYS; glycogen synthase [EC:2.4.1.11] K00693 GYS; glycogen synthase [EC:2.4.1.11] K00750 GYG1; glycogenin [EC:2.4.1.186] K00750 GYG1; glycogenin [EC:2.4.1.186 ...
Hall MA, Norman PJ, Thiel B, Tiwari H, Peiffer A, Vaughan RW, Prescott S, Leppert M, Schork NJ, Lanchbury JS, Quantitative trait loci on chromosomes 1, 2, 3, 4, 8, 9, 11, 12, and 18 control variation in levels of T and B lymphocyte subpopulations. Am J Hum Genet70(5):1172-82 ...
Evidence of a locus on BTA5 involved in the expression of the rat-tail phenotype in the SEGFAM-population. In: 15th Day of the Doctoral Student : abstracts, 13 May 2014 Dummerstorf (Schriftenreihe / Leibniz-Institut für Nutztierbiologie , 23) : 29-32 ...
Evidence of a locus on BTA5 involved in the expression of the rat-tail phenotype in the SEGFAM-population. In: 15th Day of the Doctoral Student : abstracts, 13 May 2014 Dummerstorf (Schriftenreihe / Leibniz-Institut für Nutztierbiologie , 23) : 29-32 ...
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The ability to sense gravity is enhanced by an extracellular structure that overlies the macular sensory epithelium. This complex consists of high density particles, otoconia, embedded within a gelatinous membrane. The tilted mouse specifically lacks otoconia, yet has no other detectable anatomic lesions. Furthermore, the penetrance of the tilted phenotype is nearly 100%. This mouse provides a model to identify genes that are involved in the development and function of vestibular otoconia. Using SSLP markers, we have mapped the tilted (tlt) gene on mouse Chromosome (Chr) 5 between D5Mit421 and D5Mit353/D5Mit128/D5Mit266/D5Mit267 by analysis of the progeny of an intersubspecific F2 intercross. We also mapped the fibroblast growth factor receptor 3 (Fgfr3) gene, a potential candidate for tlt, and the Huntingtons disease homolog (Hdh) gene to D5Mit268, approximately 4.3 centiMorgans (cM) from the tilted locus. This study excludes both Fgfr3 and Hdh as candidate genes for tlt and identifies closely linked
SM/J mice carry a number of rare polymorphic alleles and are often matched to other strains for quantitative trait locus analysis. These mice are susceptible to diet-induced obesity and diet-induced atherosclerosis. SM/J mice exhibit a hyperresponsiveness to B cell mitogens. Small in size at birth and through weaning, SM/J mice attain a normal body weight as they age.
Virology Highlights features highlighted articles published in Virology, with posts summarizing the research in the authors words.
Understanding the genetic component of scoliosis in humans has relied on the assumption that spine development is conserved across species. Since evolutionary conserved genes tend to lie within synteny blocks (HSBs) and genes which are not conserved lie within evolutionary breakpoint regions (EBRs), HSB analysis may be used to determine if spine development is conserved across species. We hypothesized that vertebral patterning genes are conserved in amniotes and their location is within stable or
Note: Not all QTL on a chromosome are shown due to space; Go to a chromosome for more complete QTL reports; Click on a QTL name to see more details on that QTL ...
Note: Not all QTL on a chromosome are shown due to space; Go to a chromosome for more complete QTL reports; Click on a QTL name to see more details on that QTL ...