Background: Mental retardation can be caused by copy number variations (deletions, insertions, duplications), ranging in size from 1 kb to several megabases. Array based comparative genomic hybridisation (array-CGH) allows detection of an increasing number of genomic alterations.. Methods: A series of 46 patients with mental retardation and congenital abnormalities (previously screened for subtelomeric rearrangements) were evaluated for cryptic chromosomal imbalances by array-CGH. This array contains 6465 large-insert BAC/PAC clones, representing sequences uniformly distributed throughout the human genome. The results were confirmed by alternative techniques.. Results: Four pathogenic rearrangements were detected: two of them were novel, a deletion at 2q31.2 and a duplication at 8q12 band; the other two have been previously reported-a duplication of the Williams-Beuren region and a deletion of 3q29. By adding the subtelomeric alterations previously identified, a total rate of 18% of pathogenic ...
Bioluminescent-labelling allows sensitive non-invasive sequential imaging of tumor development and early metastasis. Current methods for the genetic modification of cells typically use integrating genotoxic viruses that can potentially disrupt the molecular behavior of cancer cell lines due to their random nature of integration. VAL401 is the reformulation of a clinical drug to enable use in the treatment of cancer. Preclinical data indicate potential use of the reformulated drug in lung cancer, where many subsets of patients have currently a high unmet medical need. We have utilized a non-viral DNA vector that comprises an S/MAR (Scaffold/Matrix Attachment Region) element to stably modify cells to be further used in xenograft studies to allow long term expression without affecting cell behavior or silencing over cell divisions. Human BxPC3 pancreatic cancer cells were stably transfected with a pSMARt-UBC-Luc and cultured for 4 weeks under selection. Colonies that formed after this period were ...
Isabel C. Barrio, Elin Lindén, Mariska Te Beest, Johan Olofsson, Adrian Rocha, Eeva M. Soininen, Juha M. Alatalo, Tommi Andersson, Ashley Asmus, Julia Boike, Kari Anne Bråthen, John P. Bryant, Agata Buchwal, C. Guillermo Bueno, Katherine S. Christie, Yulia V. Denisova, Dagmar Egelkraut, Dorothee Ehrich, LeeAnn Fishback, Bruce C. Forbes, Maite Gartzia, Paul Grogan, Martin Hallinger, Monique M. P. D. Heijmans, David S. Hik, Annika Hofgaard, Milena Holmgren, Toke T. Høye, Diane C. Huebner, Ingibjörg Svala Jónsdóttir, Elina Kaarlejärvi, Timo Kumpula, Cynthia Y. M. J. G. Lange, Jelena Lange, Esther Le´vesque, Juul Limpens, Marc Macias-Fauria, Isla Myers-Smith, Erik J. van Nieukerken, Signe Normand, Eric S. Post, Niels Martin Schmidt, Judith Sitters, Anna Skoracka, Alexander Sokolov, Natalya Sokolova, James D. M. Speed, Lorna E. Street, Maja K. Sundqvist, Otso Suominen, Nikita Tananaev, Jean-Pierre Tremblay, Christine Urbanowicz, Sergey A. Uvarov, David Watts, Martin Wilmking, Philip A. ...
Transgenic cattle carrying multiple genomic modifications have been produced by serial rounds of somatic cell chromatin transfer (cloning) of sequentially genetically targeted somatic cells. However, cloning efficiency tends to decline with the increase of rounds of cloning. It is possible that multiple rounds of cloning compromise the genome integrity or/and introduce epigenetic errors in the resulting cell lines, rendering a decline in cloning. To test these possibilities, we performed 9 high density array Comparative Genomic Hybridization (CGH) experiments to test the genome integrity in 3 independent bovine transgenic cell lineages generated from genetic modification and cloning. Our plan included the control hybridizations (self to self) of the 3 founder cell lines and 6 comparative hybridizations between these founders and their derived cell lines with either high or low cloning efficiencies. We detected similar amounts of differences between the control hybridizations (8, 13 and 39 differences)
Hox genes are essential for proper embryonic development. In mammals, 39 genes are found clustered at four genomic loci, and their internal topological.... Read more about Of HOX and TADs: The Genetic Basis of Pre-formation ...
A pilot study at the National Institute of Standards and Technology (NIST), in support of the National Cancer Institutes Early Detection Research Network (EDRN), has validated the measurement accuracy of new techniques that use mitochondrial DNA as an early indicator for certain types of cancer. Additional results suggest that a relatively simple diagnostic test using a DNA microarray chip could enable early detection of some solid tumors, including lung cancer. Mitochondrial DNA (mtDNA) plays a role in respiration and the cells energy conversion mechanism. Since the late 1990s, researchers at the Johns Hopkins University School of Medicine have observed changes in mtDNA sequences in solid cancers, although the nature of the relationship remains uncertain. Their work suggested that particular changes in mtDNA might serve as early indicators for several types of solid cancer. Although promising, this approach is critically dependent on developing reliable, cost-effective, and highly sensitive ...
Scroll-Type Fluid Machiner - A scroll-type fluid machine is configured so that the scroll-type fluid machine has compact, lightweight, and long life characteristics obtained by mounting, without increasing the diameter of the barrel, a bearing having a higher load capacity and so that a degradation in the performance due to a pressure loss during a high flow-rate operation is minimized by providing the gas flow path in the center plate with a sufficient cross-sectional area. A scroll-type fluid machine is provided with: a first housing which contains a scroll mechanism; a second housing which contains an electric motor; and a center plate which is disposed between both the housings, which contains a motion conversion mechanism for converting rotational motion to orbiting motion, which has mounted thereto a rotation prevention mechanism for preventing the rotation of a movable scroll, and which holds the bearing for supporting the main shaft. At least a part of the fluid path, which connects the ...
Galli, T et al Tetanus toxin-mediated cleavage of cellubrevin impairs exocytosis of transferrin receptor-containing vesicles in CHO cells.. The Journal of Cell Biology 125.5 (1994): 1015-1024. Web. 23 Oct. 2019. ...
Nielutulehdus-suosituksen historiatiedot «Nielutulehdus, Käypä hoito -suosituksen historiatiedot»9. Puheenjohtaja:. Hans Blomberg, LL, yleislääketieteen erikoislääkäri; Sipoon terveyskeskus. Jäsenet:. Hannele Kotilainen, LL, sisätautien- ja infektiotautien erikoislääkäri, kaupunginepidemiologi; Helsingin terveyskeskus, Kaupunginsairaala, Epidemiologinen yksikkö. Tommi Liukko, LL; HYKS:n korva-, nenä- ja kurkkutautien klinikka, Suomen Terveystalo. Marjukka Mäkelä, tutkimusprofessori; Menetelmien arviointiyksikkö Finohta, Terveyden ja hyvinvoinnin laitos. Alpo Vuorio, LT, työterveyslääkäri; Mehiläinen Airport, Vantaa ja Työterveyslaitos, Lappeenranta (Käypä hoito -toimittaja). Asiantuntijat:. Olli-Pekka Alho, korva-, nenä- ja kurkkutautiopin professori; OYS:n korva-, nenä- ja kurkkutautien klinikka. Pentti Huovinen, LKT, erikoislääkäri, bakteeriopin professori, tutkimusprofessori; Turun yliopisto ja Terveyden ja hyvinvoinnin laitos. Hannu Sarkkinen, dosentti; ...
Nokia announced that it had reached 63 commercial 5G contracts worldwide, positioning among the global leaders in the delivery of end-to-end 5G solutions.. The figure includes Nokias customers such as AT&T, KDDI, Korea Telecom, LG Uplus, NTT DOCOMO, O2, SK Telecom, SoftBank, Sprint, STC, T-Mobile US, Verizon, Vodafone Italy and Zain Saudi from key 5G early adopter and progressive markets.. This milestone highlights the quality and customer confidence in our 5G portfolio and we expect this to continue this year with the addition of many more new deals, said Tommi Uitto, President of Mobile Networks at Nokia. Our global end-to-end portfolio includes products and services for every part of a network, which are helping network operators to enable key 5G capabilities such as network slicing, distributed cloud and the industrial Internet of Things. We are delighted that our technologies are helping to shape the delivery and deployment of 5G technologies worldwide and the myriad benefits these will ...
CGH stands for comparative genome hybridisation, which aims to compare the presence / absence / number of similar genes in 2 genomes (i.e. its a survey of genetic differences between 2 organisms). So, a CGH experiment might compare gemomic DNA from 2 closely related bacterial species or strains. The difference between CGH array experiments and gene expression array experiments is just the target which is hybridised to the array: labelled genomic DNA for CGH; labelled cDNA (or cRNA - derived from mRNA in either case) for gene expression. You can use exactly the same arrays for both types of experiment, although the objective of CGH is normally genome-wide comparison of 2 genomes, so CGH normally uses whole-genome microarrays (for prokaryotes, at least). In general, you can use any genomic array for either gene expression or CGH ...
Rice (Oryza sativa) is the first grass species to be sequenced, and as of September 2002, there are four draft genome sequences available. All four drafts are available to the academic community, although two drafts have some limitations with respect to access and distribution. Although none of the four draft sequences is complete, they collectively provide our first view of the landscape and the content of a monocot genome.. The first rice genome sequence made accessible in large tracts was that of the O. sativa subsp japonica cv Nipponbare generated by the International Rice Genome Sequencing Project (IRGSP;Sasaki and Burr, 2000), an international consortium of public laboratories. Using a bacterial artificial chromosome (BAC)-by-BAC approach, the IRGSP has generated draft sequence of 3,083 BAC or P1 artificial chromosome (PAC) clones that is available through GenBank/DNA data bank of Japan (DDBJ)/EMBL (as of September 17, 2002). These 3,083 BAC/PAC clones represent 426 Mb of sequence, and ...
Entrance Of Xizhimen, A Young Man In A Casual White Suit And Preparation Materials A White Bowler Hat, Holding A White Box In His Hand, Asked Everyone Hey Buddies. Wu Jucai S Words Sscp Certification In His Heart But For Jujucai, It Is The Admiration From The Bottom Of My Heart He Had Only Had Such A Good Deal With Him. Girl To Long Shao, Not Only Long Shao Will Help Himself, He Will Even Bring Himself In The Future If That S The Case, In Examinations The Capacity Of Long. Hospital, What Does It Have To Do With You You Re Just A Little Nurse Here, guarantee It S Really Wide The Little Nurse Was Stomped By Wu Jucai S. Some Sense Of Security, Which Will Be A Little Better Those Guys Should Not Dare To Mess Up Yo, It Looks Pretty, And The Figure Is Really. Neither The Previous Boss Nor Anyone He Met After The 70-247 Certification Casino Was As Good To Him As Fearless When I Knew That My Sister S Treatment Cost Was. As Lin Jue Entered The Hospital, He Saw Wu Jucai Lying On The Bed Immediately ...
FERRARIS KIMI RAIKKONEN is poised to make his debut in the World Rally Championship after it was announced he would compete in his home event, Rally Finland, next month.. Raikkonen, who has already competed in three minor events earlier in the year, will contest the rally in a Fiat Grande Punto S2000 alongside countryman Kaj Lindstrom, a former co-driver of four-time World Champion Tommi Makinen.. Incidentally, it will be Makinens rally outfit team, Tommi Makinen Racing that will prepare Raikkonens car for the event, the former Formula 1 World Champions first on gravel.. Lindstrom believes the challenge of competing in a gravel event will prove a stern test of Raikkonens ability to adapt to ever changing conditions.. ...
Development of protein kinase inhibitors is a focus of many drug discovery programs. A major problem, however, is the limited specificity of the commonly used adenosine triphosphate-competitive inhibitors and the weak inhibition of the more selective substrate-competitive inhibitors. Glycogen synthase kinase-3 (GSK-3) is a promising drug target for treating neurodegenerative disorders, including Alzheimers disease (AD), but most GSK-3 inhibitors have not reached the clinic. We describe a new type of GSK-3 inhibitor, L807mts, that acts through a substrate-to-inhibitor conversion mechanism that occurs within the catalytic site of the enzyme. We determined that L807mts was a potent and highly selective GSK-3 inhibitor with reasonable pharmacological and safety properties when tested in rodents. Treatment with L807mts enhanced the clearance of β-amyloid loads, reduced inflammation, enhanced autophagic flux, and improved cognitive and social skills in the 5XFAD AD mouse model. This new modality of ...
Interfaces between materials with differently ordered phases present unique opportunities to study fundamental problems in physics. One example is the interface between a singlet superconductor and a half-metallic ferromagnet, where Cooper pairing occurs between electrons with opposite spin on the superconducting side, whereas the other exhibits 100% spin polarization. The recent surprising observation of a supercurrent through half-metallic CrO2 therefore requires a mechanism for conversion between unpolarized and completely spin-polarized supercurrents. Here, we suggest a conversion mechanism based on electron spin precession together with triplet-pair rotation at interfaces with broken spin-rotation symmetry. In the diffusive limit (short mean free path), the triplet supercurrent is dominated by inter-related odd-frequency s-wave and even-frequency p-wave pairs. In the crossover to the ballistic limit, further symmetry components become relevant. The interface region exhibits a superconducting state
Looking for Micrometer Caliper? Find out information about Micrometer Caliper. micrometer a measuring instrument whose conversion mechanism consists of a screw-nut micropair. Micrometer calipers are used to measure linear dimensions by... Explanation of Micrometer Caliper
TY - JOUR. T1 - Relaxation mechanisms of UV-photoexcited DNA and RNA nucleobases. AU - Barbatti, Mario. AU - Aquino, Adélia J.A.. AU - Szymczak, Jaroslaw J.. AU - Nachtigallová, Dana. AU - Hobza, Pavel. AU - Lischka, Hans. PY - 2010/12/14. Y1 - 2010/12/14. N2 - A comprehensive effort in photodynamical ab initio simulations of the ultrafast deactivation pathways for all five nucleobases adenine, guanine, cytosine, thymine, and uracil is reported. These simulations are based on a complete nonadiabatic surface-hopping approach using extended multiconfigurational wave functions. Even though all five nucleobases share the basic internal conversion mechanisms, the calculations show a distinct grouping into purine and pyrimidine bases as concerns the complexity of the photodynamics. The purine bases adenine and guanine represent the most simple photodeactivation mechanism with the dynamics leading along a diabatic ππ* path directly and without barrier to the conical intersection seam with the ...
Kuti9 was published in autumn 2008 with 28 pages from the Kuti team and 8 extra pages from the Finnish small press distributor Toivo. Featuring art from: Lilli Carré (USA), The Duuzers (FIN), Martin Ernstsen (NOR), Roope Eronen (FIN), Tom Gauld (UK), Matti Hagelberg (FIN), Kaltsu Kallio (FIN), Bendik Kaltenborn (NOR), Kapreles (NED), Tommi Musturi (FIN), Sami Myllyniemi (FIN), Jyrki Nissinen (FIN), Jaakko Pallasvuo (FIN), Aapo Rapi (FIN), Anna Sailamaa (FIN), Bart Schoofs (BEL), Olivier Schrauwen (BEL), Jerry Scoundrel (FRA), Walter Schifftate (USA), Petteri Tikkanen (FIN) and Jari Vaara (FIN). The issue includes an article about Yuichi Yokoyama (in Finnish) and about Extrapool (in English). Kuti9 is included in the collection of the St. Patricks Zine Library. ...
Agra, Rosa María; Al-Daghri, Nasser M; Badimon, Lina; Bodi, Vicente; Carbone, Federico; Chen, Mao; Cubedo, Judit; Dullaart, Robin P F; Eiras, Sonia; García-Monzón, Carmelo; Gary, Thomas; Gnoni, Antonio; González-Rodríguez, Águeda; Gremmel, Thomas; Hafner, Franz; Hakala, Tommi; Huang, Baotao; Ickmans, Kelly; Irace, Concetta; Kholová, Ivana; Kimer, Nina; Kytö, Ville; März, Winfried; Miazgowski, Tomasz; Møller, Søren; Montecucco, Fabrizio; Niccoli, Giampaolo; Nijs, Jo; Ozben, Serkan; Ozben, Tomris; Papassotiriou, Ioannis; Papastamataki, Maria; Reina-Couto, Marta; Rios-Navarro, Cesar; Ritsch, Andreas; Sabico, Shaun; Seetho, Ian W; Severino, Anna; Sipilä, Jussi; Sousa, Teresa; Taszarek, Aleksandra; Taurino, Federica; Tietge, Uwe J F; Tripolino, Cesare; Verloop, Willemien; Voskuil, Michiel; Wilding, John P ...
Sigma-Aldrich offers abstracts and full-text articles by [Tommi Pätilä, Shigeru Miyagawa, Yukiko Imanishi, Satsuki Fukushima, Antti Siltanen, Eero Mervaala, Esko Kankuri, Ari Harjula, Yoshiki Sawa].
A new one from Helsinki with an incredible Tommi Björk section (6:13), a shared Simo Mäkelä and Olli Lilja part and one hell of an ender.. By Jaro Serlas and Mikko Björk.. Cover image by Justus Hirvi.. ...
Drug Class and Mechanism. Fexofenadine is an oral, second generation antihistamine that is used to treat the signs and symptoms of allergy that are due to histamine. It is similar to the other second generation antihistamines loratadine (Claritin), cetirizine (Zyrtec) and azelastine (Astelin). Histamine is a chemical that is responsible for many of the signs and symptoms of allergic reactions, for example, swelling of the lining of the nose, sneezing, and itchy eyes. Histamine is released from histamine-storing cells (mast cells) and then attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be activated, releasing other chemicals that produce the effects that we associate with allergy, e.g., sneezing. Fexofenadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of H1 receptor-containing cells by histamine. Unlike the first generation antihistamines, fexofenadine and other ...
TY - JOUR. T1 - High-Resolution Genomic Arrays Facilitate Detection of Novel Cryptic Chromosomal Lesions in Myelodysplastic Syndromes. AU - OKeefe, Christine L.. AU - Tiu, Ramon. AU - Gondek, Lukasz P.. AU - Powers, Jennifer. AU - Theil, Karl S.. AU - Kalaycio, Matt. AU - Lichtin, Alan. AU - Sekeres, Mikkael A.. AU - Maciejewski, Jaroslaw P.. PY - 2007/2/1. Y1 - 2007/2/1. N2 - Objective: Unbalanced chromosomal aberrations are common in myelodysplastic syndromes and have prognostic implications. An increased frequency of cytogenetic changes may reflect an inherent chromosomal instability due to failure of DNA repair. Therefore, it is likely that chromosomal defects in myelodysplastic syndromes may be more frequent than predicted by metaphase cytogenetics and new cryptic lesions may be revealed by precise analysis methods. Methods: We used a novel high-resolution karyotyping technique, array-based comparative genomic hybridization, to investigate the frequency of cryptic chromosomal lesions in a ...
We have developed FISH Oracle, an interactive web-based application to visualize segment data from an unlimited number of array CGH experiments in the context of gene annotations. Functional elements and segments are presented in a clear and concise fashion. Moreover, the zooming capability of the system makes it possible to display all elements at the resolution desired by the user. Easy to use filters allow to select groups of segments to be visualized. We expect that the high quality of the visualization and the flexibility of the software will enable life scientists to quickly derive interesting hypotheses about candidate cancer genes occurring in amplified or deleted regions. To communicate their findings, users can quickly export the generated images in different high quality formats, e.g. for publication or post-processing using standard graphics software. FISH Oracle is flexible regarding the underlying genome as long as the segment data refer to the same sequence basis as an annotation ...
To protect structures from short duration shock load in various engineering applications, a novel energy conversion mechanism with concept design is proposed. Different from conventional methods with cellular solid/structure dissipating input translational kinetic energy to plastic strain energy with large compressive deformation, the proposed approach converts part of incident translational kinetic energy to rotational kinetic energy, which is not detrimental to the protected structure. The mechanism of energy conversion is analyzed and formulated, with key factors governing the conversion efficiency identified and discussed, which sheds light on alternative approach for short duration load mitigation.
Karen S W Leong, Thilini N Jayasinghe, José G B Derraik, Benjamin B Albert, Valentina Chiavaroli, Darren M Svirskis, Kathryn L Beck, Cathryn A Conlon, Yannan Jiang, William Schierding, Tommi Vatanen, David J Holland, Justin M OSullivan, Wayne S Cutfield ...
04854 Plastic plant in blister box AP052C size S UnionStar - Plastic aquarium plant with a real look. Size. S, 10cm Importer: Tommi CZ s.r.o., www.tommicz.eu
Fexofenadine is an oral, second generation antihistamine that is used to treat the signs and symptoms of allergy that are due to histamine. It is similar to the other second generation antihistamines loratadine (Claritin), cetirizine (Zyrtec) and azelastine (Astelin). Histamine is a chemical that is responsible for many of the signs and symptoms of allergic reactions, for example, swelling of the lining of the nose, sneezing, and itchy eyes. Histamine is released from histamine-storing cells (mast cells) and then attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be activated, releasing other chemicals that produce the effects that we associate with allergy, e.g., sneezing. Fexofenadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of H1 receptor-containing cells by histamine. Unlike the first generation antihistamines, fexofenadine and other second-generation antihistamines ...
Fexofenadine is an oral, second generation antihistamine that is used to treat the signs and symptoms of allergy that are due to histamine. It is similar to the other second generation antihistamines loratadine (Claritin), cetirizine (Zyrtec) and azelastine (Astelin). Histamine is a chemical that is responsible for many of the signs and symptoms of allergic reactions, for example, swelling of the lining of the nose, sneezing, and itchy eyes. Histamine is released from histamine-storing cells (mast cells) and then attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be activated, releasing other chemicals that produce the effects that we associate with allergy, e.g., sneezing. Fexofenadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of H1 receptor-containing cells by histamine. Unlike the first generation antihistamines, fexofenadine and other second-generation antihistamines ...
Complete publications list available from: NASA ADS Author Search: Tommi Koskinen. Refereed publications (NASA ADS): Calendar Years 2017 through June 2020. Vriesema, J. W., Koskinen, T. T., Yelle, R. V. Electrodynamics in Saturns thermosphere at low and middle latitudes 2020Icar..34413390V. Brown, Z., Koskinen, T., Müller-Wodarg, I., West, R., Jouchoux, A., Esposito, L. A pole-to-pole pressure-temperature map of Saturns thermosphere from Cassini Grand Finale data 2020NatAs.tmp...75B. Koskinen, T. T., Sandel, B. R., Yelle, R. V., Holsclaw, G. M., Quemerais, E. Saturn in Lyman α: A comparison of Cassini and Voyager observations 2020Icar..33913594K. Cubillos, P. E., Fossati, L., Koskinen, T., Young, M. E., Salz, M., France, K., Sreejith, A. G., Haswell, C. A. Near-ultraviolet Transmission Spectroscopy of HD 209458b: Evidence of Ionized Iron Beyond the Planetary Roche Lobe 2020AJ....159..111C. Turner, J. D., de Mooij, E. J. W., Jayawardhana, R., Young, M. E., Fossati, L., Koskinen, T., ...
Shigella flexneri is the major pathogen causing bacillary dysentery in developing countries. S. flexneri is divided into at least 16 serotypes based on the combination of antigenic determinants present in the O-antigen. All the serotypes (except for serotype 6) share a basic O-unit containing one N-acetyl-d-glucosamine and three l-rhamnose residues, whereas differences between the serotypes are conferred by phage-encoded glucosylation and/or O-acetylation. Serotype Xv is a newly emerged and the most prevalent serotype in China, which can agglutinate with both MASF IV-1 and 7,8 monoclonal antibodies. The factor responsible for the presence of MASF IV-1 (E1037) epitope has not yet been identified. In this study, we analyzed the LPS structure of serotype Xv strains and found that the MASF IV-1 positive phenotype depends on an O-antigen modification with a phosphoethanolamine (PEtN) group attached at position 3 of one of the rhamnose residues. A plasmid carried gene, lpt-O (LPS phosphoethanolamine
Shigella flexneri is the major pathogen causing bacillary dysentery in developing countries. S. flexneri is divided into at least 16 serotypes based on the combination of antigenic determinants present in the O-antigen. All the serotypes (except for serotype 6) share a basic O-unit containing one N-acetyl-d-glucosamine and three l-rhamnose residues, whereas differences between the serotypes are conferred by phage-encoded glucosylation and/or O-acetylation. Serotype Xv is a newly emerged and the most prevalent serotype in China, which can agglutinate with both MASF IV-1 and 7,8 monoclonal antibodies. The factor responsible for the presence of MASF IV-1 (E1037) epitope has not yet been identified. In this study, we analyzed the LPS structure of serotype Xv strains and found that the MASF IV-1 positive phenotype depends on an O-antigen modification with a phosphoethanolamine (PEtN) group attached at position 3 of one of the rhamnose residues. A plasmid carried gene, lpt-O (LPS phosphoethanolamine
Twenty-eight genetic loci have been physically mapped to specific large restriction fragments of the Streptococcus mutans GS-5 chromosome by hybridization with probes of cloned genes or, for transposon-generated amino acid auxotrophs, with probes for Tn916. In addition, restriction fragments generated by one low-frequency-cleavage enzyme were used as probes to identify overlapping fragments generated by other restriction enzymes. The approach allowed construction of a low resolution physical map of the S. mutans GS-5 genome using restriction enzymes ApaI (5'-GGGCC/C), SmaI (5'-CCC/GGG), and NotI (5'-GC/GGCCGC).
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a transcriptosomal complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity).
Mitochondrial DNA (mtDNA) copy number regulation is altered in several human mtDNA-mutation diseases and it is also important in a variety of normal physiological processes. Mitochondrial transcription factor A (TFAM) is essential for human mtDNA transcription and we demonstrate here that it is also a key regulator of mtDNA copy number. We initially performed in vitro transcription studies and determined that the human TFAM protein is a poor activator of mouse mtDNA transcription, despite its high capacity for unspecific DNA binding. Next, we generated P1 artificial chromosome (PAC) transgenic mice ubiquitously expressing human TFAM. The introduced human TFAM gene was regulated in a similar fashion as the endogenous mouse Tfam gene and expression of the human TFAM protein in the mouse did not result in down-regulation of the endogenous expression. The PAC-TFAM mice thus had a net overexpression of TFAM protein and this resulted in a general increase of mtDNA copy number. We used a
Smith-Magenis syndrome (SMS) is a mental retardation syndrome with distinctive behavioral characteristics, dysmorphic features, and congenital anomalies ascribed to an interstitial deletion of chromosome 17p11.2. Severe sleep disturbances and maladaptive daytime behavior have been linked to an abnor …
We undertook clinical evaluation (32 cases) and molecular evaluation (31 cases) of unrelated patients affected with Smith-Magenis syndrome (SMS) associated with an interstitial deletion of band p11.2 of chromosome 17. Patients were evaluated both clinically and electrophysiologically for peripheral …
Moshier, M. S., York, T. P., Silberg, J. L. and Elsea, S. H. (2012), Siblings of individuals with Smith-Magenis syndrome: an investigation of the correlates of positive and negative behavioural traits. Journal of Intellectual Disability Research, 56: 996-1007. doi: 10.1111/j.1365-2788.2012.01581.x ...
Sloneem, J and Oliver, C and Udwin, O and Woodcock, K (2011) Prevalence, phenomenology, aetiology and predictors of challenging behaviour in Smith-Magenis syndrome. Journal Of Intellectual Disability Research. ...
Tommi, Kate, and Zara are all elite competitors on the circuit, but they come from. This app makes it relatively easy to design inquiry lessons with iCircuit as the main visual and interactive component. Training program. To the uninitiated these layer types can be quite confusing, but once you have a basic understanding, youll see that it is all quite simple. A circuit diagram is a visual display of an electrical circuit using either basic images of parts or industry standard symbols. Wiring is not necessary, but can be used to show wiring that i. ) Very Simple. i want to communicate the arduino & nodeMCU together, so that i can read the value from arduino uno to nodeMCU. Its advanced simulation engine can handle both analog and digital circuits and features realtime always-on analysis. ‬ iCircuit is the easy to use electronic circuit simulator and designer - the perfect tool for students, hobbyists, and engineers. Disclosure: I am affiliated with the company that makes and sells this app. ...
Raine Sihvonen, Mika Paavola, Antti Malmivaara, Ari Itälä, Antti Joukainen, Heikki Nurmi, Juha Kalske, Anna Ikonen, Timo Järvelä, Tero A H Järvinen, Kari Kanto, Janne Karhunen, Jani Knifsund, Heikki Kröger, Tommi Kääriäinen, Janne Lehtinen, Jukka Nyrhinen, Juha Paloneva, Outi Päiväniemi, Marko Raivio, Janne Sahlman, Roope Sarvilinna, Sikri Tukiainen, Ville-Valtteri Välimäki, Ville Äärimaa, Pirjo Toivonen, Teppo L N Järvinen The FIDELITY (Finnish Degenerative Meniscal Lesion Study) Investigators ...
In the past five years we have identified the developmental stage of Tcell differentiation at which malignant transformation caused by retroviral insertion of a...
Smith-Magenis Syndrome (SMS) is a genetic disorder with features including intellectual disability, facial abnormalities, difficulty sleeping, and numerous behavioral problems such as self-harm. Smith-Magenis syndrome affects an estimated between 1 in 15,000 to 1 in 25,000 individuals. It is a microdeletion syndrome characterized by an abnormality in the short (p) arm of chromosome 17 and is sometimes called the 17p- syndrome. Facial features of children with Smith-Magenis syndrome include a broad face, deep-set eyes, large cheeks, and a prominent jaw, as well as a flat nose bridge. The mouth curves downwards and the upper lip curves outwards. These facial features become more noticeable as the individual ages. Disrupted sleep patterns are characteristic of Smith-Magenis syndrome, typically beginning early in life. Affected people may be very sleepy during the day, but have trouble falling asleep and awaken several times each night, due to an inverted circadian rhythm of melatonin. People with ...
Smith-Magenis Syndrome is a rare chromosomal disorder characterized by abnormalities of the head and facial (craniofacial) area, delays in the acquisition of skills requiring the coordination of mental and muscular activities (psychomotor retardation), mental retardation, speech delays, and/or behavioral abnormalities.
Smith-Magenis syndrome (SMS) is a genetic condition which causes noticeable physical characteristics and some cognitive difficulties. Children with SMS tend to...
Passerelle was always going to be special.. Our intention: to create a distinctive perfume with links to classic French perfumery, an Australian perfume that reflects the unique floral notes of our native flora. But where to begin? To go forward you must also look back.. By researching the history of colonial Australia we discovered the French also sent explorers south, not to conquer but to enrich French culture with the natural wonders of Terre Australis.. For Passerelle we gathered an Australian Spring floral bouquet of delicate native jasmine, starry tea tree, soft honeyed myrtle, the crisp notes of boronia buds and the much loved flowers of silver wattle, adopted by the French and known to the world as mimosa. We chose yellow rose, honeysuckle, wintersweet and golden trumpet to reflect the warmth of the Australian sun and to add a cosmopolitan edge to Passerelle. Adding these golden flowers of joy to our native bouquet we then spun fine threads of Australian sandalwood amongst the blooms ...
We have developed a procedure for efficient in situ hybridization of bacterial recombinants created with various types of large-insert cloning vectors. Minimal quantities of crude DNA are amplified and labeled during the degenerate-oligonucleotide-primed polymerase chain reaction. The resulting probes generate high-intensity fluorescent hybridization signals on metaphase chromosomes and on interphase nuclei.
MOUNT VERNON, Mo. - Missouri agriculture officials are receiving reports of cattle dying after grazing on drought-stressed grass. The University of Missouri Extension service says the problem is johnsongrass. During droughts like this years, it can accumulate dangerous levels of nitrates and prussic acid.
Detection of biomolecules and biological nanoparticles by means of induced aggregation of larger nanoparticles using light scattering as readout was first accomplished in the middle of the last century. Since then, technical advances together with novel nanomaterials have enabled more sophisticated readout schemes, paving the way for methods exploiting dual-probe hybridization for biomolecular or nonoparticle recognition that today can compete with established bioanalytical methods. Herein, we present a quantitative assay, with single-nanoparticle readout, utilizing receptor-containing cell-membrane mimics in the shape of approximately 100-nm lipid liposomes rather than conventional antibody-modified nanoparticles to enable detection of virus particles in solution. Specifically, the method is based on virus-mediated aggregation of differently fluorescent-labeled liposomes that contain the ganglioside GM1 receptor for the Simian Virus 40 (SV40). The aggregation kinetics of the differently colored
THE OHIO STATE JOURNAL VOLUME VII. CO LUMBUS, SATURDAY, JUNE 29, 1844. NUMBER 204. PUBLISHED ON TUESDAYS, THURSDAYS AND SATURDAYS, BY SCOTT St TEESDALE. Ornci corner odliga and Town street, Bultlef Building. TERMS. Daily during tho session of the Legislature, and tri-weckly the remainder or tho year $& 00 Tri-wcckly per annum 4 00 Weekly per annum 100 rpiIK barribcr hna nuoHnird with him Mr. R. X Fitch, and will continue tho lroluce and Commission Ilusiness under the iirm of 8. THOM AS & CO., at tho White Warehouse at the west end ol the Scioto llridgo, where Ihcy will be ready to attend promptly to any business that may be entrusted to them. Advauccuients made on consignments when required. S. THOMAS. May 1, IBM STUO T1AN cV tO. Forwarding nnd tommi. aio .rrchnnis Oviirrnl Produce Denlera, Agents IorN. York and Buffalo Lake lioal line; John Allens Clintoa line, and Ohio and N. York line, on the Krio Caual; T. Richmond & Co.s Diamond Line, on the Ohio Canal. While Want-House, West end ...
The best part of this trip, minus having to share my bed with FAYETH, is that I get to spend time with some of my favorite Chiari Moms. (Just wait until camp, THAT is a lot of fun, 23 of my favorite Chiari Families!!!!) Kristen has flown in from OK and I will pick her up in Mt. Prospect this afternoon. Our friend Tommi had to cancel due to her daughters surgical wound infection. Cindy will be coming along with her friend Jenni (whom I have yet to meet) Kristen and I are sharing a room. No Kids. No listening to Mommy, Mommy Mommy ...
Smith-Magenis syndrome repeat gene cluster, proximal, made of some 14 genes and pseudogenes comprising one copy of KIAA00565, and sequence homolog to LGALS9, NOS2A, SRP68, UPF3A, USP6 ...
Fingerprint Dive into the research topics of The role of spinal angiography in the evaluation and treatment of pediatric spinal vascular pathology: a case series and systematic review. Together they form a unique fingerprint. ...
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