Synonyms for aureolic acid in Free Thesaurus. Antonyms for aureolic acid. 1 synonym for mithramycin: Mithracin. What are synonyms for aureolic acid?
Comparative studies on histology and histochemistry of pancreas between Labeo calbasu (Hamilton, 1822) and Mystus gulio (Hamilton, 1822)
FDA approves vaccine to block meningitis strain - AP News: WASHINGTON (AP) - Federal health regulators have approved the first .01/18/2018 3:26:41AM EST.
Heronamides A - C, new polyketide macrolactams from an Australian marine-derived Streptomyces sp. A biosynthetic case for synchronized tandem electrocyclization. Ritesh R. et al. Org. Biomol. Chem. 2010, 8, 4682.. ...
127D: Conformation of B-DNA containing O6-ethyl-G-C base pairs stabilized by minor groove binding drugs: molecular structure of d(CGC[e6G]AATTCGCG complexed with Hoechst 33258 or Hoechst 33342.
The five samples 6480-6464 (6473-6480 bottom of core, 6473-6480 middle of core, 6473-6480 top of core, 6464-6470 bottom of core, 6464-6470 middle of core, 6464-6470 top of core) contain nothing that is significant and very little at all. A few crinoid stems, fragments of Fenestrellina, and a Sulcoretepora. The sample 6462-6464 contains Fusulina and is of Pennsylvanian age. In the conversation between Mr. Lee and me concerning this sample, Mr. Lee said that it was almost certainly misplaced. I would think the same, as there are no other Pennsylvanian samples in the entire core. The next 13 samples, ranging from 6293 to 6114 (6291-6293 with intermediate samples to 6114-6119), contain no fossils so far as ascertained. Core 6051-6065 (samples 1-5) contain fossils in sample 1, which is the top, and in samples 2 and 5, as follows: Worthenopora spinosa, fragments of a Spirifer related to S. keokuk and S. washingtonensis, a finely costate Spirifer (fragment) possibly S. lateralis, and Rhipidomella aff. ...
TY - JOUR. T1 - Quantitative footprinting analysis of the chromomycin A3-DNA interaction. AU - Stankus, Allison. AU - Goodisman, Jerry. AU - Dabrowiak, James C.. PY - 1992. Y1 - 1992. N2 - Chromomycin A3 (CHR) binding to the duplex d(CAAGTCTGGCCATCAGTC)· d(GACTGATGGCCAGACTTG) has been studied using quantitative footprinting methods. Previous NMR studies indicated CHR binds as a dimer in the minor groove. Analysis of autoradiographic spot intensities derived from DNase I cleavage of the 18-mer in the presence of various amounts of CHR revealed that the drug binds as a dimer to the sequence 5′-TGGCCA-3′, 3′-ACCGGT-5′ in the 18-mer with a binding constant of (2.7 ± 1.4) × 107 M-1. Footprinting and fluorescence data indicate that the dimerization constant for the drug in solution is ∼ 105 M-1. Since it has been suggested that CHR binding alters DNA to the A configuration, quantitative footprinting studies using dimethyl sulfate, which alkylates at N-7 of guanine in the major groove, ...
The cancer-cell-cytotoxicity-guided fractionation of the acetone extracts of two cultured marine-derived Streptomyces strains belonging to the MAR4 group yielded six new napyradiomycins, compounds A-F (1-6), together with three known compounds, napyradiomycins B2-B4 (7-9). Napyradiomycins 1-4 are new members of the napyradiomycin C-type meroterpenoids, which possess a linear monoterpene bridge between C-7 and C-10a. Compound 4 has an additional tetrahydropyran ring fused to the phenol moiety. Compounds 5-9 are related to the napyradiomycin B-type meroterpenoids. The structures of all new compounds were assigned by interpretation of 1D and 2D NMR, MS, and other spectroscopic data. The relative configurations were assigned based upon interpretation of ROESY 2D NMR experiments. The cytotoxicity of 1-9 against the human colon carcinoma cell line HCT-116 and their antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) are presented.. ...
1EKH: A high-resolution structure of a DNA-chromomycin-Co(II) complex determined from pseudocontact shifts in nuclear magnetic resonance.
Ilan E.Z, Torres M.R, Prudhomme J., Le Roch K., Jensen PR, Fenical W. 2013. Farnesides A and B, sesquiterpenoid nucleoside ethers from a marine-derived Streptomyces sp., strain CNT-372 from Fiji. Journal of Natural Products. 76:1815-1818. ...
15112992] Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs. (Chem Biol. , 2004 ...
Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002] ...
TY - JOUR. T1 - Synthesis and DNA-binding properties of bisdiazoliumylporphyrins. AU - Tjahjono, Daryono H.. AU - Yamamoto, Tomoko. AU - Ichimoto, Sumito. AU - Yoshioka, Naoki. AU - Inoue, Hidenari. PY - 2000. Y1 - 2000. N2 - A pair of 5,15-bisdiazoliumylporphyrins with only two meso-substituents, 5,15-bis(1,3-dimethylimidazolium-2-yl)-porphyrin 1b and 5,15-bis(1,2-dimethylpyrazolium-4-yl)porphyrin 2b, has been synthesized. The crowded porphyrin 1b intercalates between base pairs of DNA to stabilize the duplex DNA to thermal denaturation due to its high affinity for DNA. The binding of porphyrin 1b to DNA is an exothermic interaction and enthalpically driven. Porphyrin 1b interacts more strongly with poly(dA-dT)2 than with poly(dG-dC)2, and the interaction is more favorable or selective to AT-rich sites than to GC-rich sites.. AB - A pair of 5,15-bisdiazoliumylporphyrins with only two meso-substituents, 5,15-bis(1,3-dimethylimidazolium-2-yl)-porphyrin 1b and ...
PER VRETBLAD; Biospecific Affinity Chromatography of Sweet-Potato β-Amylase. Biochem Soc Trans 1 December 1974; 2 (6): 1327-1328. doi: https://doi.org/10.1042/bst0021327. Download citation file:. ...
Define mithramycin. mithramycin synonyms, mithramycin pronunciation, mithramycin translation, English dictionary definition of mithramycin. Noun 1. mithramycin - an antineoplastic drug used to treat cancer of the testes Mithracin antineoplastic antibiotic - an antibiotic drug used as an...
The contributions from the secondary structure of the transcriptional activator protein C of bacteriophage Mu to its specific DNA binding and the influence of various factors, viz ., electrolytes, and minor groove and major groove binders on this protein-DNA interaction have been addressed . Circular dichroism (CD) spectral results suggest that, in the absence of Mg2+, C protein exhibits a j3-pleated sheetlike structure and Mg2+ changes the conformation to a more a-helical structure which could provide specific geometrical constraints complementary to those of DNA helix. Thus, Mg 2+ acts as a cofactor for the binding of the C protein to its specific site in DNA by inducing conformational changes in the protein. Competitive binding studies with minor and major groove binding drugs, viz ., distamycin A and methyl green, respectively, and the DMS footprinting data indicate that the C protein recognizes the major groove of DNA during complex formation . Further, upon major groove binding, C protein ...
Plicamycin (INN, also known as mithramycin; trade name Mithracin) is an antineoplastic antibiotic produced by Streptomyces plicatus. It is an RNA synthesis inhibitor. The manufacturer discontinued production in 2000. Several different structures are currently reported in different places all with the same chromomycin core, but with different stereochemistry in the glycoside chain, a 1999 study has re-investigated the compound and proposed a revised structure. Plicamycin has been used in the treatment of testicular cancer, Pagets disease of bone, and, rarely, the management of hypercalcemia. Plicamycin has been tested in chronic myeloid leukemia. Plicamycin is currently used in multiple areas of research, including cancer cell apoptosis and as a metastasis inhibitor. One elucidated pathway shows it interacts by cross-binding chromatin GC-rich promoter motifs, thereby inhibiting gene transcription. "Mithramycin A". Fermentek. Wohlert, S. E.; Künzel, E.; Machinek, R.; Méndez, C.; Salas, J. A.; ...
Development of industrial producers of antibacterial (ristomycin, linkomycin, apramycin, tobramycin, heliomycin, eremomycin) and antitumor (daunorubycin, carminomycin, bleomycin, olivomycin, bruneomycin) ...
The structure of the synthetic deoxyoctamer d(GGIGCTCC) has been determined by single crystal X-ray diffraction techniques to a resolution of 1.7A. The sequence crystallises in space group P6(1), with unit cell dimensions a = b = 45.07, c = 45.49A. The refinement converged with a crystallographic residual R = 0.14 and the location of 81 solvent molecules. The octamer forms an A-DNA duplex with 6 Watson-Crick (G.C) base pairs and 2 inosine-thymine (I.T) pairs. Refinement of the structure shows it to be essentially isomorphous with that reported for d(GGGGCTCC) with the mispairs adopting a "wobble" conformation. Conformational parameters and base stacking interactions are compared to those for the native duplex d(GGGGCCCC) and other similar sequences. A rationale for the apparent increased crystal packing efficiency and lattice stability of the I.T octamer is given. Refined crystal structure of an octanucleotide duplex with I.T. mismatched base pairs.,Cruse WB, Aymani J, Kennard O, Brown T, Jack ...
Various approaches are used to study the chromosomal makeup of cells. Traditional cytogenetic methods are based on the analysis of mitotic cells fixed onto slides to analyze their chromosomal composition (karyotype) by microscopy. This approach can be combined with FISH to detect specific sequences on morphologically distinct individual chromosomes. Disadvantages of this type of microscopic analysis are the amount of time and labor required to acquire and analyze typically less than a hundred cells. As a result, the statistical power of this type of analysis is limited. An alternative to traditional cytogenetic methods is flow karyotyping (1,2) a method to analyze chromosomes in suspension by flow cytometry. For bivariate flow karyotyping, the DNA composition of specific chromosomes in suspension is measured based on the DNA-specific dyes Hoechst 33258 and chromomycin A3 (3,4). In our protocol, we combine flow karyotyping and FISH to analyze repetitive DNA in individual chromosomes by flow ...
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SWISS-MODEL Repository entry for B3GZ69 (KTHY_ACTP7), Thymidylate kinase. Actinobacillus pleuropneumoniae serotype 7 (strain AP76)
Despite the critical roles of excited states in protein functions, they remain intractable for most structural studies because of their notably low populations. Chemical shifts for
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... , also known as Maniatis, has served as the foundation of technical expertise in labs worldwide for 30 years. No other manual has been so popular, or so influential.
The pathogenic fungus Fonsecaea pedrosoi constitutively produces the pigment melanin, an important virulence factor in fungi. Melanin is incorporated in the cell wall structure and provides chemical and physical protection for the fungus. We evaluated the production of nitric oxide (NO) in macrophages, the oxidative burst and the inducible nitric oxide synthase (i-NOS) activity in interactions between activated murine macrophages and F. pedrosoi. Experiments were carried out with or without tricyclazole (TC) treatment, a selective inhibitor of the dihydroxynaphthalene (DHN)-melanin biosynthesis pathway in F. pedrosoi. The paramagnetisms of melanin and the TC-melanin were analysed by electron spin resonance. The fungal growth responses to H2O2 and to S-nitroso-N-acetylpenicillamine (SNAP), a nitric oxide donor, were also evaluated. Melanised F. pedrosoi cells were more resistant to both H2O2 and NO. Nitrite was not detected in the supernatant of macrophages incubated with melanised fungal cells. However,
TY - JOUR. T1 - Immunological cross reaction between calf and Drosophila histones. AU - Bustin, M.. AU - Reeder, R. H.. AU - McKnight, S. L.. PY - 1977. Y1 - 1977. UR - http://www.scopus.com/inward/record.url?scp=0017387756&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0017387756&partnerID=8YFLogxK. M3 - Article. C2 - 856814. AN - SCOPUS:0017387756. VL - 252. SP - 3099. EP - 3101. JO - Journal of Biological Chemistry. JF - Journal of Biological Chemistry. SN - 0021-9258. IS - 9. ER - ...
Online obituary for Rita Levi-Montalcini. Read Rita Levi-Montalcinis life story, offer tributes/condolences, send flowers or create a Rita Levi-Montalcini online memorial.
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Just a quick update for those of you wondering how Rita is doing... The answer is: better. She is having a good time seeing lots of other kitties at Barbs house and has perked up a good deal. She is still having trouble passing stool, and needs nightly massages to help her do that. Very…
Euphorbia Linnaeus, 1753 (Euphorbiaceae) is one of the most diverse and complex genera among the angiosperms, showing a huge diversity in morphologic traits and ecologic patterns. In order to improve the knowledge of the karyotype organization of Euphorbia hirta (2n = 18) and E. hyssopifolia (2n = 12), cytogenetic studies were performed by means of conventional staining with Giemsa, genome size estimations with flow cytometry, heterochromatin differentiation with chromomycin A3 (CMA) and 4,6-diamidino-2-phenylindole (DAPI) and Giemsa C-banding, fluorescent in situ hybridization (FISH) with 45S and 5S rDNA probes, and impregnation with silver nitrate (AgNO3). Our results revealed small metacentric chromosomes, CMA+/DAPI0 heterochromatin in the pericentromeric regions of all chromosomes and CMA+/DAPI− in the distal part of chromosome arms carriers of nucleolar organizing regions (NORs). The DNA content measurements revealed small genomes for both species: E. hirta with 2C = 0.77 pg and E. hyssopifolia
The reproduction of twenty-seven strains of Fonsecaea pedrosoiwas studied. The denticulate type (asexual reproduction) showed three morphological variations: medium-size, long and sessile forms....
Online obituary for Rita Levi-Montalcini. Read Rita Levi-Montalcinis life story, offer tributes/condolences, send flowers or create a Rita Levi-Montalcini online memorial.
RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2, disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis.
Rita Sahat iu Ora (born 26 November 1990), better known as Rita Ora, is a British singer-songwriter and actress. 95-106 Capital FM Summertime Ball 2012 at
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Description from Flora of China. Lycopodioides Boehmer, nom. rej.; Selaginoides Séguier; Stachygynandrum P. Beauvois ex Mirbel, nom. rej.. Morphological characters and geographic distribution are the same as those of the family.. Five subgenera are recognized. In a molecular phylogeny (Korall et al., Int. J. Pl. Sci. 160: 585-594. 1999), the isophyllous Selaginella subg. Selaginella (absent from China) and S. subg. Tetragonostachys Jermy are monophyletic, but the anisophyllous S. subg. Stachygynandrum Warburg and S. subg. Heterostachys Warburg are not monophyletic.. Six uncertain taxa, not included in the following key, are listed at the end of the account. Uncertain taxa Selaginella effusa Alston var. dulongjiangensis W. M. Chu (Fl. Yunnan. 20: 718. 2006), described from Gongshan, Yunnan. Selaginella jugorum Handel-Mazzetti (Symb. Sin. 6: 8. 1929; Lycopodioides jugorum (Handel-Mazzetti) H. S. Kung), described from NW Yunnan. Selaginella monospora Spring var. ciliolata W. M. Chu (Fl. Yunnan. ...
DNA topoisomerase I (EC 5.99.1.2) [1,2,3,4] is one of the two types of enzyme that catalyze the interconversion of topological DNA isomers. Type I topoisomerases act by catalyzing the transient breakage of DNA, one strand at a time, and the subsequent rejoining of the strands. When a prokaryotic type I topoisomerase breaks a DNA backbone bond, it simultaneously forms a protein-DNA link where the hydroxyl group of a tyrosine residue is joined to a 5-phosphate on DNA, at one end of the enzyme-severed DNA strand. Prokaryotic organisms, such as Escherichia coli, have two type I topoisomerase isozymes: topoisomerase I (gene topA) and topoisomerase III (gene topB). Eukaroytes also contain homologs of prokaryotic topoisomerase III. There are a number of conserved residues in the region around the active site tyrosine; we used this region as a signature pattern. Last update: December 2004 / Pattern and text revised. ...
IMMUNOPATHOGENESIS OF PCM The establishment of the disease, its spread and severity depend on factors inherent to the fungus itself, as its virulence, antigenic composition, environmental conditions and especially those factors related to the hosts ability to develop an effective immune response. With regard to the latter aspect, we can consider that P. brasiliensis synthesizes metabolic antigens which interact with the host immune system, causing an immunological response that is both highly complex and multifactorial.14 Clinical and experimental studies have suggested an interaction between specific and nonspecific defense mechanisms in determining resistance to P. brasiliensis.11, 24 P. brasiliensis presents a complex antigenic structure, with epitopes that are related to pathogenicity. The main antigenic component of P. brasiliensis is a surface glycoprotein of fungal wall with 43 kDa (gp43), an immunodominant antigen associated with virulence factor and/or escape by which the fungus evades ...
Dr. Rita Sattler is a researcher at Barrow Neurological Institute. Her work focuses on synaptic biology in health and disease. Read more.
See what Rita Somogyiné Bejczi (ritasomogyinbejczi) has discovered on Pinterest, the worlds biggest collection of everybodys favorite things.
How excited was Rita Ora about being cast in this months film adaptation of the mega-bestselling softcore-porn novel Fifty Shades of Grey? Just ask
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Fourteen Fonsecaea pedrosoi isolates from six chromoblastomycosis patients were submitted to susceptibility testing. Some patients were undergoing treatment with itraconazole (ITZ) and/or cryosurgery with liquid nitrogen. The antifungal agents amphotericin B (AMB), ITZ, fluconazole (FCZ), ketoconazo …
Abbreviations: BRCA1, breast-cancer susceptibility gene 1; BARD1, BRCA1-associated RING domain protein 1; E-box, enhancer box; ERα, oestrogen receptor α; HDAC, histone deacetylase; hnRNP, heterogeneous nuclear ribonucleoprotein; HSP27, heat-shock protein 27; N-CoR, nuclear receptor co-repressor; NLS, nuclear localization signal; RBMX, X-chromosome linked RNA-binding motif; RRM, RNA-recognition motif; SAFB1, scaffold attachment factor B1; SAF-box, scaffold attachment factor-box; XOR, xanthine oxidoreductase ...
Supplementary Materials10858_2019_233_MOESM1_ESM. from transfer of nuclear polarization via dipolar couplings between spin pairs. In alternative, the main experimental variables are NOE-derived interproton length (r) restraints, which range with 1/r6, supplemented Duocarmycin GA by torsion position restraints extracted from J-couplings1,2, 1H and 13C shifts3,4, residual dipolar couplings5C9 aswell as the usage of conformational data source potentials10,11, paramagnetic rest improvements (PRE)12C14, pseudocontact shifts (Personal computers)15 and additional complementary data. Proteins structure dedication by magic angle rotating solid-state NMR (MAS NMR) exploits dipolar couplings between heteronuclear spin pairs and requires the usage of range restraints, extracted from carbon-nitrogen or carbon-carbon dipolar-based relationship tests and their proton-mediated variations, such as for example proton-driven spin diffusion PDSD16,17, dipolar-assisted rotary resonance DARR18C20, mixed RN-symmetry ...
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