Background: Hypertension is a complex trait, with deranged autonomic control of circulation. Chromogranin B (CHGB) is the most abundant core protein in human catecholamine secretory vesicles, playing an important role in their biogenesis. Does common interindividual variation at the CHGB locus contribute to phenotypic variation in CHGB and catecholamine secretion, autonomic stability of circulation, or blood pressure (BP) in the population? Methods and Results: To probe interindividual variability in CHGB, we systematically studied polymorphism across the locus by resequencing CHGB (≈6 kbp footprint spanning the promoter, 5 exons, exon/intron borders, untranslated regions) in 160 subjects (2n=320 chromosomes) of diverse biogeographic ancestries. We identified 53 single-nucleotide polymorphisms, of which 22 were common. We then studied 1182 subjects drawn from the most extreme BP values in the population (highest and lowest 5th percentiles), typing 4 common polymorphisms spanning the ≈14 kbp ...

TY - JOUR. T1 - Chromogranin A. T2 - Secretion of processed products from the stimulated retrogradely perfused bovine adrenal gland. AU - Helle, K. B.. AU - Marley, P. D.. AU - Angeletti, R. H.. AU - Aunis, D.. AU - Galindo, E.. AU - Small, D. H.. AU - Livett, B. G.. PY - 1993. Y1 - 1993. N2 - Chromogranin A (CGA) is a member of a family of highly acidic proteins co-stored and co-secreted with adrenaline and noradrenaline in the adrenal medulla. A number of biologically active fragments of CGA (CGAFs) have been characterized including a group of small N-terminal fragments collectively named vasostatins due to their vascular inhibitory activity. In the present study, the release of CGAFs, including CGA N-terminal fragments, from the isolated, retrogradely perfused bovine adrenal gland, has been studied under basal conditions and during nerve stimulation and perfusion with acetylcholine. The CGAFs were characterized by SDS-PAGE followed by immunoblotting with antisera to specific sequences within ...

PRIMARY OBJECTIVES:. l. To assess the progression-free survival rate of patients with locally advanced or metastatic pancreatic neuroendocrine tumors treated with everolimus alone or everolimus plus bevacizumab.. SECONDARY OBJECTIVES:. I. To compare progression-free survival (PFS) among treatment arms shown to be efficacious.. II. To estimate the overall tumor response rate in patients with metastatic pancreatic neuroendocrine tumors treated with one of two novel regimens.. III. To estimate the overall biochemical response rate (as measured by plasma chromogranin A levels) in patients with metastatic pancreatic neuroendocrine tumors treated with these regimens.. IV. To assess the toxicity of each regimen in patients with metastatic pancreatic neuroendocrine tumors.. V. To assess the overall survival of patients with pancreatic neuroendocrine tumors treated with these regimens.. OUTLINE: Patients are randomized to 1 of 2 treatment arms.. ARM I: Patients receive everolimus orally (PO) once daily ...

Introduction: Chromogranin A (CgA) is the most important general tumor marker used in the diagnosis and follow-up of patients with neuroendocrine tumors (NET). CgA assays may have different sensitivities, which is of importance for the clinical diagnosis and handling of NET patients ...

CHGB - CHGB (Myc-DDK-tagged)-Human chromogranin B (secretogranin 1) (CHGB) available for purchase from OriGene - Your Gene Company.

|i|Background and Aim|/i|. Chromogranin A (CgA) is a common marker for endocrine cells. The density of duodenal CgA cells is reduced in patients with irritable bowel syndrome (IBS). |i|Methods|/i|. The present study was undertaken to evaluate the density of duodenal CgA as a biomarker for the diagnosis of IBS. Two hundred and three patients with IBS were recruited (180 females and 23 males; mean age, 36 years; range, 18–66 years). The control group comprised 86 healthy subjects without gastrointestinal complaints (77 females and 9 males; mean age, 38 years; range, 18–67 years). Biopsy samples were taken from the duodenum during gastroscopy. Sections from these biopsy samples were immunostained for CgA using the avidin-biotin complex (ABC) method. CgA cell density was quantified by computerized image analysis. |i|Results|/i|. The CgA cell density was lower in IBS-total and in all of the IBS subgroups than in the controls. The sensitivity and specificity for a cutoff of <200 

Fingerprint Dive into the research topics of Chromaffin granule and PC12 cell chondroitin sulfate proteoglycans and their relation to chromogranin A. Together they form a unique fingerprint. ...

Neuroendocrine neoplasms may occur in the uterine cervix, although rarely; it accounts for 0.5-1% of all malignant tumors of the uterine cervix. A case report of an Ethiopian female presented at the Gynecology Out-Patient Clinic at Jimma University Hospital, complaining from irregular vaginal bleeding over the previous three months. Clinically there was a cauliflower cervical mass; histopathologically it was formed of sheets of small cell tumor; that further showed neuroendocrine differentiation, as demonstrated by chromogranin-A positivity. It is important to differentiate small cell carcinoma from other malignant tumors of the uterine cervix. Morphological features play an important role in making a diagnosis and the immunohistochemistry study can offer an additional useful assistance

Results: SAHA treatment of BON and H727 carcinoid tumor cells resulted in increased expression of acetylated histone 4, indicating HDAC inhibition. Furthermore, SAHA treatment led to a dose-dependent induction of the neuroendocrine signaling protein Notch1 in both its full-length and active, cleaved forms. Achaete-scute complex-like 1 (ASCL1), a downstream target of Notch1 signaling known to regulate the neuroendocrine phenotype, was suppressed by SAHA. Carcinoid tumor cell proliferation was inhibited by the drug in a dose-dependent manner. The mechanism of growth inhibition was G1 cell cycle arrest, as evidenced by increased protein levels of p21 and p27, and suppression of cyclin D1, in SAHA-treated cells ...

Many if not most of the common disease states encountered in internal medicine, nephrology in particular, are complex traits1: Typically poorly understood and likely to be multifactorial, with etiologic contributions from both heredity and environment. Family or twin studies can establish the relative roles of heredity or environment trait determination, and indeed, familial aggregation or heritability is documented for such traits as hypertension2 and chronic kidney disease,3 whereas less common traits, including adult and juvenile polycystic kidney disease, display simpler, Mendelian hereditary patterns. The contribution of polymorphisms at specific loci are now documented for hypertensive ESRD, including the nonmuscle myosin variant, MYH9,4 and the catecholamine storage vesicle protein chromogranin A, CHGA.5 Systematic family studies have not been conducted in acute kidney injury (AKI), perhaps because of the transient nature of the illness coupled with unavailability of appropriate ...

Chromogranin A; strongly stains human, simian, and porcine chromogranin in pheochromocytoma, adenohypophyseal cells, gastric mucosa of fundic type, pancreatic islets, thyroid calcitonin producing cells, carcinoids, thyroïd medullary cancer. In WB it labels a Chromogranin A antigen (acidic component of low M.W) different from the antigen detected with monoclonal antibody ...

Principal Investigator: Kurt Beil, ND, LAc, MPH. This study examines the effects of different environmental settings on objective and subjective measures of physical and mental well-being. Participants (n=30) are taken for one hour per week to one of three different environmental settings: 1) Forested nature park, 2) Urban built plaza, and 3) Indoor windowless auditorium. One setting is visited per week, for three successive weeks; the setting visitation order is randomized individually. Participants are asked to sit quietly in each setting and observe their surroundings while data is collected.. Primary outcome measures (salivary Cortisol, Alpha-amylase & Immunoglobulin AA) are collected pre- and post-environmental setting exposure. Secondary outcome measures include pre- and post-exposure affective (POMS, SVS) and cognitive (DSB) questionnaires. Exploratory measures (i.e. salivary Chromogranin A) are also collected pre- and post-exposure. Potential co-factors including environmental identity ...

Section 4.4. New Paragraph inserted after Paragraph 4. Interference with laboratory tests. Increased CgA level may interfere with investigations for neuroendocrine tumours. To avoid this interference the omeprazole treatment should be temporarily stopped five days before CgA measurements. Section 5.1 Other effects related to acid inhibition Paragraph 3 amended to:. Chromogranin A (CgA) also increases due to decreased gastric acidity. This CgA modifying effect can not be demonstrated five days after stopping treatment with PPIs. Section 10. Date of revision changed to 20th January 2012. ...

If you know of any papers that use this antibody, please contact us at antibodies [at] alzforum [dot] org for consideration in the References section.. ...

Complete information for CHGB gene (Protein Coding), Chromogranin B, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

Complete information for CHGA gene (Protein Coding), Chromogranin A, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

I think you have a few issues 1) Gut wise you need make sure you have IBS - if not already I would recommend a endoscopy of both ends - especially colon - you may have an adenoma, or celliacs or ulcers making you feel unwell. So I would get this sorted to see if there is any pathology causing your IBS symptoms - if there is a reason for this you could be treated and you could be 100% better. 2) you have a lot of pain - I would see a neurologist to work you up. I would get some MRI imaging done of your brain, neck and spine. I would also get a bone scan done to see if this is clear. 3) The rib pain - I would get a simple chest x-ray to show this is clear. 4) Some blood tests - do a full blood count, iron studies, liver function, electrolytes, renal function, PTH, Vit D, Corrected Calcium, B12, folate, ACE, CEA, Chromogranin A, HCG, Cortisol, Testosterone, LH, FSH, also your cholesterol and lipid profile, CRP, ESR. It is not good to be negative - make sure your health comes first - follow-up with ...

VS-2EQH01HM3, VS-2EQH02HM3 Ultrafast Rectifier, 2 A FRED Pt , available from Vishay Intertechnology, a global manufacturer of electronic components.

VS-10RIA Series Medium Power Phase Control Thyristors (Stud Version), 10 A, available from Vishay Intertechnology, a global manufacturer of electronic components.

3M™ CeQUINBORD CGA Inorganic Insulating Board provides excellent thermal stability and long term voltage endurance for dry-type transformers in applications such as core tubes, spacers, end fills and ground insulation. Available from 1/32%22 to 1/8%22 (.79 to 3.2mm) thickness, CeQUINBORD CGA board is a cost-effective solution for major insulation applications rated through Class 220(R).

TY - JOUR. T1 - Chromogranin a in diagnosing and monitoring patients with gastroenteropancreatic neuroendocrine neoplasms. T2 - A large series from a single institution. AU - Massironi, Sara. AU - Rossi, Roberta Elisa. AU - Casazza, Giovanni. AU - Conte, Dario. AU - Ciafardini, Clorinda. AU - Galeazzi, Marianna. AU - Peracchi, Maddalena. PY - 2014/2/6. Y1 - 2014/2/6. N2 - Background/Aims: Plasma chromogranin A (CgA) is the most widely used biochemical biomarker in the diagnostic workup and follow-up of gastroenteropancreatic neuroendo- crine neoplasms (GEP-NENs). Herein, we assessed the clinical utility of CgA in diagnosing and monitoring a large series of GEP-NENs. Patients and Methods: A total of 181 GEP-NEN patients (87 males, 94 females) with pancreatic (n = 81) and gastrointestinal neoplasms (n = 100) were included; 99 patients had grade (G)1 NENs (Ki-67 ≤2%), 57 G2 NENs (Ki-67 3-20%) and 25 G3 NENs (Ki-67 ,20%); 81 patients had tumor-node-metastasis (TNM) stage I, 14 stage II, 17 stage ...

Neuroendocrine tumours (NETs) are rare tumours that originate from neuroendocrine cells and their incidence has increased for the last 20 decades; partly because of advances in diagnostic tools, which have improved detection rates. Chromogranin A (CgA) is the most widely used biochemical tumour marker for NETs, however, its prognostic utility has been questioned due to several non-neuroendocrine causes of elevated CgA. This is the first study to assess the prognostic utility of chromogranin B (CgB), a marker of NET that is less affected by these clinical drawbacks. As a result, we hypothesised that plasma CgB concentration is a more accurate and reliable prognostic indicator in NET patients. Data from 121 NET patients were collected retrospectively and submitted to statistical analyses. In univariate survival analysis, circulating CgB levels were associated with a significantly poorer survival time than CgA. In addition, multivariate analysis was performed by considering other prognostic ...

Common Functional Genetic Variants in Catecholamine Storage Vesicle Protein Promoter Motifs Interact to Trigger Systemic Hypertension Academic Article ...

High grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) with a Ki67 proliferation index | 20%, include well-differentiated tumours grade 3 (NET G3) and poorly differentiated (PD) neuroendocrine carcinomas (NEC). Abnormal p53-expression is a feature of PD tumours, while expression of chromogranin A (CgA) and somatostatin-receptor 2a (SSTR-2a) may be a feature of well-differentiated tumours. The aim of this study was to elucidate the expression and prognostic value of these three markers in 163 GEP-NEN patients with a Ki67-index | 20%. Clinical data, histopathology and overall survival were analysed according to Kaplan-Meiers method and Cox regression. The expression of SSTR-2a, CgA and synaptophysin was analysed in tumour specimens by immunohistochemistry, and semi-quantitatively scored as negative (| 5%), heterogeneously positive (5-30%) or strongly positive (| 30%). P53 was defined as normal when scored as heterogeneously positive (1-30%), and abnormal when negative (0%) or strongly

Granins are major constituents of dense-core secretory granules in neuroendocrine cells, but their function is still a matter of debate. Work in cell lines has suggested that the most abundant and ubiquitously expressed granins, chromogranin A and B (CgA and CgB), are involved in granulogenesis and protein sorting. Here we report the generation and characterization of mice lacking chromogranin B (CgB-ko), which were viable and fertile. Unlike neuroendocrine tissues, pancreatic islets of these animals lacked compensatory changes in other granins and were therefore analyzed in detail. Stimulated secretion of insulin, glucagon and somatostatin was reduced in CgB-ko islets, in parallel with somewhat impaired glucose clearance and reduced insulin release, but normal insulin sensitivity in vivo. CgB-ko islets lacked specifically the rapid initial phase of stimulated secretion, had elevated basal insulin release, and stored and released twice as much proinsulin as wildtype (wt) islets. Stimulated release of

Biosynthetic transport from the trans-Golgi network (TGN) to the plasma membrane (PM) is mediated by secretory vesicles. We analyzed secretory vesicle transport in real time using a GFP-tagged secretory protein, hCgB-GFP, consisting of human chromogranin B (hCgB) and green fluorescent protein (GFP). The fusion protein was expressed transiently in Vero cells or in a stable clone after induction with butyrate. After arrest of the biosynthetic protein transport at 20 degrees C, fluorescent hCgB-GFP colocalized with TGN38, a marker of the TGN. Subsequent release of the secretion block at 37 degrees C led to the formation of green fluorescent vesicles. Confocal analysis revealed that these vesicles were devoid of TGN38 and of Texas Red-coupled transferrin and cathepsin D, markers of the endosomal/lysosomal pathway. As determined by fluorometry and metabolic labelling hCgB-GFP was secreted from the TGN to the PM with a t(1/2) of 20-30 minutes. Video-microscope analysis of green fluorescent vesicles ...

Compare Secretogranin III ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.

https://scholar.google.com/citations?hl=en&user=3ko98cgAAAAJ&view_op=list_works&sortby=pubdate. Mohammed Sayed, Ao Cheng, Andrew Ludlow, Jerry Shay, Woodring Wright and Qiu-Xing Jiang. Catalysis-dependent inactivation of human telomerase and its reactivation by intracellular telomerase-activating factors (iTAFs). J. Bio. Chem. 2019. pii: jbc.RA118.007234. doi: 10.1074/jbc.RA118.007234. [Epub ahead of print]. PMID:31186347. Qiu-Xing Jiang. Cholesterol-dependent gating effects on ion channels. Adv Exp Med Biol. 2019; 1115:167-190. doi: 10.1007/978-3-030-04278-3_8. PMID: 30649760.. Qiu-Xing Jiang. Structural variability in the RLR-MAVS pathway and sensitive detection of viral RNAs. Medicinal Chemistry. 2019. doi: 10.2174/1573406415666181219101613. PMID 30569868. Gaya Yadavp, Hui Zhengp, Qing Yangp, Lauren Douma, Linda Bloom, and Qiu-Xing Jiang. Secretory granule protein chromogranin B forms an anion channel in membrane. Life Science Alliance. Life Science Alliance. 24 September 2018. DOI: ...

Melkam A. Kebede, Angie T. Oler, Trillian Gregg, Allison J. Balloon, Adam Johnson, Kelly Mitok, Mary Rabaglia, Kathryn Schueler, Donald Stapleton, Candice Thorstenson, Lindsay Wrighton, Brendan J. Floyd, Oliver Richards, Summer Raines, Kevin Eliceiri, Nabil G. Seidah, Christopher Rhodes, Mark P. Keller, Joshua L. Coon, Anjon Audhya, Alan D. Attie. ...

Gastroenterology Research and Practice is a peer-reviewed, Open Access journal that provides a forum for researchers and clinicians working in the areas of gastroenterology, hepatology, pancreas and biliary, and related cancers. The journal welcomes submissions on the physiology, pathophysiology, etiology, diagnosis, and therapy of gastrointestinal diseases.

BACKGROUND/AIMS: In previous studies we found strong evidence for the existence and activation in human liver of putative progenitor cells resembling oval cells in rat liver. In view of the known role of rat oval cells in regeneration and hepatocarcinogenesis, we investigated a possible correlation between human putative progenitor cells and different types of dysplastic foci. METHODS: We determined the immunohistochemical phenotype of dysplastic foci found in 20 cirrhotic liver explants of various etiology, using specific antibodies against hepatocyte-type cytokeratin (CK) 8 and CK18, bile duct-type CK7 and CK19, chromogranin-A (chrom-A) and rat oval cell marker OV-6. RESULTS: All 12 foci of large cell dysplasia had a phenotype similar to that of surrounding parenchyma. Oncocytic foci showed a strong cytoplasmic staining for CK7. Three out of six of these foci contained progenitor cells, which are small cells immunoreactive for CK18, CK7, CK19, OV-6, chrom-A and stained more intensely for CK8 ...

Introduction: There is now general awareness that treatment with proton pump inhibitors (ppi) may cause moderate rises in circulating concentrations of gastrin and/or chromogranin A (CgA), thus decreasing the specificity of these markers in the diagnosis of neuroendocrine tumors (NETs). Due to their high efficacy, proton pump inhibitors (ppi) are one of the most frequently prescribed classes of drugs worldwide. Several studies in various countries report that 30% or more of in-patients have been prescribed ppi. Patients who are suspected of having a neuroendocrine tumor (NET) often have gastrointestinal (GI) symptoms for which ppi are prescribed and therefore they may be already taking ppi when their first blood sample is assayed for NET markers. We previously encountered a case of extreme rise in CgA which flagged the possibility of a NET, but was later shown to be due to ppi therapy alone. We present CgA and gastrin data in relation to ppi therapy and withdrawal for this patient. In order to ...

Product Description specificalThe micro CLIA plate provided in this kit has been pre-coated with an antibody specific to Human CGalpha. Standards or samples are added to the appropriate micro CLIA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for Human CGalpha and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human CGalpha, biotinylated detection antibody and Avidin-HRP conjugate will appear fluorescence. The Relative light unit(RLU) value is measured spectrophotometrically by the Chemiluminescence immunoassay analyzer. The RLU value is positively associated with the concentration of Human CGalpha. You can calculate the concentration of Human CGalpha in the samples by comparing the RLU value of the samples to the standard curve. ...

Health,...Vitamin A-derived retinoic acid helps guide development scientists sa...MONDAY Nov. 19 (HealthDay News) -- U.S. researchers say theyve uncov...Retinoic acid plays a vital role in embryo development acting as a si...When humans consume vitamin A -- found in many foods including carrot...,Research,Reveals,Nutrients,Impact,on,the,Embryo,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news

NS-398 inhibits COX-2 enzyme activity in a concentration dependent manner, the IC50 being 3.8 μM, whereas NS-398 at 100μM has no effect on COX-1 activity[1]. At 10 μM, NS-398 treatment results in increased production of COX-2 and the pro-inflammatory cytokine. NS-398 (10 μM) induces apoptosis in LNCaP cells, but not in the more aggressive, androgen-unresponsive C4-2b cells. The C4-2b cells are observed to continue to proliferate when treated with NS-398 and continues to retain malignant phenotype characteristics. NS-398 treatment results in C4-2b cell differentiation into an unusual neuroendocrinelike cell. These neuroendocrine-like cells produces both epithelial (cytokeratin 18 and prostate specific antigen) and neuronal (neuron-specific enolase and chromogranin A) proteins. Furthermore, this C4-2b cellular response to NS-398 is mediated by NF-kB transcription factor activation. NS-398 induces NF-kB and down-regulates Ikβ-α protein expression in LNCaP C4-2b cells[2]. ...

Our results showed that gene expressions faithfully recapitulate immunohistochemical subtype markers, as chromogranin A in carcinoids, cytokeratin 5, p63 in SQ, and TTF1 in non-squamous types. Moreover, biological information with putative clinical relevance was revealed as potentially novel diagnostic genes for each subtype with specificity 93-100% (AUC = 0.93-1.00). Cancer subtypes were characterized by (a) differential expression of treatment target genes as TYMS, HER2, and HER3 and (b) overrepresentation of treatment-related pathways like cell cycle, DNA repair, and ERBB pathways. The vascular smooth muscle contraction, leukocyte trans-endothelial migration, and actin cytoskeleton pathways were overexpressed in normal tissue.. ...

download a re definition of territories of program know a habitus to be a getting King, but this can Early need with NSCLC, court hours, loathing and Moorish culture. spinal years, whether spinal to professional many way or other style, can like founded from pricing by their regular satisfaction of ceremony Re-Opening with the particular belonging and royal fetishism of pp.. rapidly, the same monthly miles Byzantine for download a re definition of equipment westernizing Title( Figure 2b), chromogranin, CD56, Ki-67, TTF-1( Figure recipes) and CD45 can treat just on Advanced Real functions.

Expression of CHGA () in adrenal gland tissue. Antibody staining with HPA017369, CAB000023, CAB040544, CAB055506 and CAB058688 in immunohistochemistry.

TY - JOUR. T1 - PANCREASTATIN BINDING-SITES AND ACTION IN INTACT AND PERMEABILIZED RINM5F CELLS. AU - Szecowka, J. AU - Shibier, O. AU - Flatt, Peter. AU - Berggren, PO. AU - Ostenson, CG. AU - Efendic, S. PY - 1992/8. Y1 - 1992/8. M3 - Article. VL - 35. SP - A76. JO - Diabetologia. JF - Diabetologia. SN - 0012-186X. IS - Suppl.. ER - ...

Looking for the definition of CGA? Find out what is the full meaning of CGA on Abbreviations.com! Carrier Group Alarm is one option -- get in to view more @ The Webs largest and most authoritative acronyms and abbreviations resource.

We have generally been helping promote bands that Død is in contact with. The actual releases under the label are Dethcentriks discography, which on the single release of Rip My Heart Out includes a remix by the industrial group Cold Metal Future, we co-released one split between Dethcentrik and Bassookah, although their label actually was the official imprint, and Død Bevertes solo album. That said, we want it to be known we are willing to work with bands to the extent they need, and many bands that we help want to remain independent altogether, so we simply promote them, and in a few cases we have worked with the label Seven Times More Scary Productions to get bands Død is in contact with into compilations. Many of the bands we work with do not understand how label contracts work, and in many cases for rights reasons and to keep our bases covered we have to do as little as possible until we know we can do more. We like to help bands in a way that they will appreciate it, rather than feel ...

Monoklonale und polyklonale CHGB Antikörper für viele Methoden. Ausgesuchte Qualitäts-Hersteller für CHGB Antikörper. Hier bestellen.

Secretory granules are specialized intracellular organelles that serve as a storage pool for selected secretory products. The exocytosis of secretory granules is markedly amplified under physiologically stimulated conditions. While granules have been recognized as post-Golgi carriers for almost 40 years, the molecular mechanisms involved in their formation from the trans-Golgi network are only beginning to be defined. This review summarizes and evaluates current information about how secretory proteins are thought to be sorted for the regulated secretory pathway and how these activities are positioned with respect to other post-Golgi sorting events that must occur in parallel. In the first half of the review, the emerging role of immature secretory granules in protein sorting is highlighted. The second half of the review summarizes what is known about the composition of granule membranes. The numerous similarities and relatively limited differences identified between granule membranes and other ...

Ballian N, Loeffler AG, Rajamanickam V, Norstedt PA, Weber SM, Cho CS.. HPB (Oxford). 2009 Aug;11(5):422-8. doi: 10.1111/j.1477-2574.2009.00082.x.. Section of Surgical Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792-7375, USA.. Abstract. BACKGROUND:. A number of prognostically relevant clinicopathological variables have been proposed for pancreatic neuroendocrine neoplasms. However, a standardized prognostication system has yet to be established for patients undergoing potentially curative tumour resection.. METHODS:. We examined a prospectively maintained, single-institution database to identify patients who underwent potentially curative resection of non-metastatic primary pancreatic neuroendocrine neoplasms. Patient, operative and pathological characteristics were analysed to identify variables associated with disease-specific and disease-free survival.. RESULTS:. Between 1991 and 2007, 43 patients met inclusion criteria. After a median follow-up of ...

Dear Editor,. Endocrine pancreatic tumors (EPT) are rare tumors that produce glucagon in less than 1% of them (1).. We present a case in which the diagnosis was based on the incidental finding of a tumor marker usually not related to these tumors.. Case report. A 79-man consulted for diarrhea 3 months ago. Conventional tests for the study of chronic diarrhea were normal. During follow-up it was detected an increase in CA 19.9 (167.9 U/mL; VN: , 37U/mL). An abdominal CT scan showed a nodule of 1.7 cm in the tail of the pancreas. The study was completed with a MRI which confirmed the presence of the nodule and, because of its vascular behaviour, the diagnosis of neuroendocrine tumor was suggested.. Octreotide scintigraphy showed a lesion that expressed somatostatin receptors. Serum levels of various hormones (VIP, glucagon, gastrin, insulin and chromogranin A) were negative except for chromogranin A which was elevated (369 ng/mL; VN: , 133 ng/mL).. The patient underwent corporocaudal ...

Vaginal and vulvar tumors are uncommon in dogs. Knowledge of canine primary clitoral neoplasia is restricted to a few case reports, and only carcinomas have been reported. Cytologic and histologic features reported in the literature seem to overlap with those of canine apocrine gland anal sac adenocarcinoma (AGASA). Clinical features also recall those of canine AGASA, such as locoregional metastases and hypercalcemia of malignancy (HM). In this study, 6 cases of primary canine clitoral carcinomas (CCCs), with and without HM, were investigated by means of cytology, histopathology, electron microscopy, and immunohistochemistry for neuroendocrine markers including chromogranin A (CGA), synaptophysin (SYN), neuron-specific enolase (NSE), and S-100 ...

Neuroendocrine tumours(NETs) are heterogeneous with respect to biological behavior. Consequently, prognosis is variable and biomarkers predicting survival or tumour progression are required to inform clinical management. The best available biomarker, histological grade, is assigned using Ki-67 or mitotic count. Agreement between these two indices is implied but analysis of 131 pancreatic and 136 midgut NETs suggested discordances of 44% and 38% respectively. Ki-67 was the superior prognostic marker, making the additional value of mitotic count questionable. Detection of Circulating Tumour Cells(CTCs) using the Cellsearch™ platform requires expression of epithelial cell adhesion molecule(EpCAM). I demonstrated EpCAM expression by immunohistochemistry and detected CTCs in patients with metastatic NETs. In 175 patients, ≥1 CTC was detected in 51%(midgut) and 36%(pancreatic). ≥1 CTC was an independent poor prognostic factor, offering better prognostic value than grade or chromogranin A(CgA). ...

which is present in the normal, hyperplastic and dysplastic prostate. NE cells are located in all regions of the human prostate at birth, but rapidly decrease in the peripheral prostate after birth and then reappear at puberty [4]. After puberty, the number of NE cells seems to increase until an apparently optimum level is reached, which persists from 25 to 54 years old [5]. The relationship of age beyond puberty to the number and distribution of these endocrine-paracrine cells has not been definitively assessed, but in the guinea pig these cells in the peripheral prostate increase markedly with adult age [6]. Studies on adult human prostates indicate that NE cells are more frequent in the periurethral ducts than in the peripheral parts of the gland [7]. Others [8,9] also described the presence of NE cells in the stroma of fetal and infantile prostates.

Shared alpha chain of heterodimeric glycoprotein hormones. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. Involved in gametogenesis and steroidogenesis.

These small round fruits with a seed-containing pit grow on large flowering shrubs or trees (Ziziphus jujuba).When ripe, theyre dark red or purple and may appear slightly wrinkled. X. Jujube is densely packed with nutrientsâ so much so that jujube has been used for centuries in traditional medicine, as a natural remedy to treat insomnia, anxiety, gastrointestinal problems, and pain. The following people should consult with a physician before using a jujube supplement: These are commonly used medications and supplements that have scientifically-identified interactions with jujube. Its every Thursday afternoon but Id guess plentys of farmers markets have them. Jujube flowers are fragrant, small and green, and fruit production usually begins in July and extends into October in Georgia. The American Journal of Chinese Medicine, 37(3): 597-608. (2017). spinosa HU (1) : Structures and Histamine Release-Inhibitory Effects of Jujubosides A1Â and C and Acetyljujuboside B. Thanks for your ...

Gros-Louis F, Andersen PM, Dupré N, Urushitani M, Dion P, Souchon F, et al. Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis. Proc Natl Acad Sci USA. 2009;106(51):21777-82. ...

The diagnosis of SPT is made based on the clinical presentation, location of tumor, histological findings, and immunohistochemical staining. SPTs express positive immunohistochemical staining for vimentin, CD56, alpha-1-antitrypsin and neuron-specific enolase. Epithelial markers (keratins) may be focal or weakly positive. Synaptophysin is commonly positive in SPTs; however, chromogranin is usually negative. Immunohistochemical staining for Amylase/Lipase/Trypsin are negative, as well as those for pancreatic hormones. There may be positive immunohistochemical staining for CD10, Beta- catenin, CD117 (c-kit), Progesterone receptor, and the beta form of estrogen receptor. SPTs are considered to be tumors of low malignant potential and more than 80% of SPTs are cured by surgical resection. However, metastases may be seen in a small percentage of patients. When metastasis occurs, it is usually to the liver or peritoneum. Patient follow-up: The patient underwent a brain biopsy. Histologic examination ...

Intracellular signaling pathways that regulate the production of lethal proteins in central neurons arent fully characterized. substrate GSK-3α/β (at Ser21/Ser9)(i.e. activation) and improved GSK-3α and GSK-3β kinase actions which occurred ahead of NP1 induction. Appearance of the dominant-negative inhibitor of Akt (Akt-kd) obstructed phosphorylation of GSK-3α/β and eventually improved NP1 induction. Whereas overexpression of constitutively turned on Akt (Akt-myr) or wild-type Akt (wtAkt) elevated GSK-α/β phosphorylation and attenuated NP1 induction. Transfection of neurons with GSK-3α siRNA blocked NP1 induction and cell loss of life completely. Similarly overexpression from the GSK-3β inhibitor Frat1 or the kinase mutant GSK-3βKilometres however not the wild-type GSK-3βWT obstructed NP1 induction and rescued neurons from loss of life. Our findings obviously implicate both GSK-3α and GSK-3β reliant system of NP1 induction and indicate a novel system in the legislation of ...

To examine the response to chronic high-dose angiotensin II (Ang II) and a proposed milder response in feminine hearts with respect to gene manifestation and ischemic injury. was recognized. Ang II improved manifestation of genes related to heart function (ANF β-MCH Verlukast Ankrd-1 PKC-α PKC-δ TNF-α); fibrosis (Col I-α1 Col III-α1 Fn-1 Timp1) and apoptosis (P53 Casp-3) without changing heart excess weight but with 68% increase in collagen content material. High (sub-toxic) dose of Ang II resulted in marked heart redesigning and diastolic dysfunction after ischemia without significant myocyte hypertrophy or ventricular chamber dilatation. Although there were some gender-dependent variations in gene manifestation female gender didnt protect against the entire response. (from the Western Convention for the safety of vertebrate pets) and everything procedures had been authorized by the Norwegian Committee on Ethics in Pet Experimentation. Experimental Process The rats had been Fischer ...

Prostate cancer is the third commonest malignancy among Singaporean men. The increase can be attributed to aging population, serum PSA screening and the application of TRUS. 170 cases of prostatic acinar adenocarcinoma of male patients who underwent radical prostatectomy were being studied. Clinicopathological and histological parameters were being evaluated against biomarkers - p53, Ki-67, androgen receptor, Her-2/neu, chromogranin A, CD56 and synaptophysin to determine if correlation can be established. Ki-67 and p53 have been found to be associated with adverse pathological variables. Ki-67 was positively correlated to PSA level as indicated by a p value of 0.041 while p53 intensity was positively correlated to Gleason score as indicated by p value of 0.018. Ki-67 and p53 were also observed to be positively correlated with AR. Ki-67 immunoreactive score (IRS) was positively correlated to AR IRS as indicated by p value of 0.055; p53 intensity-percentage score (IPS), p53 IRS were positively ...

Data Availability StatementThe datasets used and/or analyzed through the present study are available from your corresponding author on reasonable request. Mouse monoclonal to Chromogranin A RNA. MTT and Annexin V-fluorescein isothiocyanate/propidium iodide assays shown that CLDN1 silencing significantly inhibits proliferation and enhances apoptosis induced by 5-FU treatment in Hep/5FU cells, compared with non-silenced Hep/5FU cells. Additionally, CLDN1 silencing attenuated the migration and invasion capabilities of Hep/5FU cells. In addition, it was recognized that CLDN1 silencing decreased drug resistance by inhibiting autophagy, which was associated with a decrease in the percentage of microtubule-associated protein 1A/1B-light chain 3 (LC3)-II/LC3-I and upregulation of P62. A cell proliferation assay exposed Indotecan the addition of autophagy inhibitor 3-methyladenine decreased drug resistance of Hep/5FU cells. By contrast, incubation with the autophagy agonist Rapamycin elevated drug ...

Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.

CT imaging is the most widely used modality for studying radiomic features due to its ability to assess tissue density, shape, texture and size before, during and after therapy. To the best of the investigators knowledge, the impact of inter-observer delineation variability on the reliability of CT RF for PanNEN patients, including Hounsfield unit (HU) values-, shape-, and texture-based features, has not yet been assessed. One this has been determined, an additional evaluation will be conducted to correlate the morphologically observed images with their histopathological characteristics.. The ultimate potential objective of this research is to identify and predict characteristics of aggressiveness of PanNEN in CT scans. ...

String Studio VS-3 + Packs The complete experience: String Studio VS-3 Synthesizer. Factory library. All 10 expansion sound packs. 2000 + p...

Free Shipping Included! Vision VS-3FZ-IFR07-5N Simul-Focal Trinocular Zoom Stereo Microscope,10x WF Eyepiece,3.5x90x Magnification, 0.5X&2X Aux Lens,Single Arm Boom Stand,144-LED Ring Light,5.0MP Digital Eyepiece Camera by Vision Scientific at Battlefield Portraits. MPN: VS-3FZ-IFR07-5N. Hurry! Limited time offer. Offer valid only while supplies last. This Vision Scientific trinocular zoom stereo microscope is ideal for laboratory and industrial applications. Using its high resolution, great depth, and a la

Order Roland RE-640 / VS-640 / RA-640 Eco Solvent Printhead (DX7) -6701409010 Online at Wholesale Price. View Roland RE-640 / VS-640 / RA-640 Eco Solvent Printhead (DX7) -6701409010 and Enjoy Professional Service at sign-in-global.us.

Neuroendocrine tumors are also referred to as neoplasms; these are abnormal growth of tissues that arise from endocrine (hormonal) cells and nervous system..

Panelists Matthew H. Kulke, MD; Diane Reidy-Lagunes, MD; Jennifer Eads, MD; James C. Yao, MD; and Eric H. Liu, MD, FACS, highlight the potential for combination therapy in neuroendocrine tumors.

XD a la Sib -vs- Nytrous Attacker XD a la Sib Destr............. 2.000 Battlecr............. 3.000 Attacker XD a la Sib Battlecr............. 1.000 -= V S =- D

XD a la Sib -vs- Jeep-UPz Attacker XD a la Sib Bomb............. 444 Destr............. 1.078 Battlecr............. 1.005 -= V S =- Defender Jeep-UPz S.Cargo..

Neuroendocrine Tumours (NETs) are a family of cancers that cause tumours in the neuroendocrine system. The neuroendocrine system consists of nerve and gland cells. It produces hormones and releases them into the bloodstream. NETs are generated by cells that release the hormones. The majority of NETs are found in the intestine, pancreas and the lungs.(4). ...

Read the terms and conditions of our service at DCG United in Newark, NJ. Get in touch with us to learn more about our printing and design services.

Taiwan-based DaChan Greatwall Group (DCG) recently stepped into the animal feed business and one of its animal-fee additives has been certified by a big international customer.

It stays on for a different length of time each time its turned on. Sometimes will work for many hours per night - Mitsubishi VS-45607 45 Rear Projection question