TY - JOUR. T1 - Serous cystic neoplasm in an intrapancreatic accessory spleen. AU - Hori, Shutaro. AU - Nara, Satoshi. AU - Shimada, Kazuaki. AU - Ojima, Hidenori. AU - Kanai, Yae. AU - Hiraoka, Nobuyoshi. PY - 2010/10/1. Y1 - 2010/10/1. N2 - Serous cystic neoplasm (SCN) of the pancreas is a benign epithelial neoplasm, except in extremely rare malignant cases. Development of SCN in tissues other than the pancreas has been never reported. Here we present the first reported case of SCN in an intrapancreatic accessory spleen (IPAS). A 54-year-old female patient with von Hippel-Lindau (VHL) syndrome was found to have pancreatic tail mass. Pathologically the 25-mm solid mass was an IPAS showing proliferation of clear cuboidal tumor cells without atypia, forming numerous small cysts. The tumor cells were rich in cytoplasmic glycogen and distributed in the splenic tissue almost diffusely. Immunohistochemically, tumor cells were positive for cytokeratins, MUC6, and neuron-specific enolase, and negative ...
Nasal glial heterotopia refers to congenital malformations of displaced normal, mature glial tissue, which are no longer in continuity with an intracranial component. This is distinctly different from an encephalocele, which is a herniation of brain tissue and/or leptomeninges, that develops through a defect in the skull, where there is a continuity with the cranial cavity. While nasal glial heterotopia (NGH) is the preferred term, synonyms have included nasal glioma. However, this term is to be discouraged, as it implies a neoplasm or tumor, which it is not. By definition, nasal glial heterotopia is a specific type of choristoma. It is not a teratoma, however, which is a neoplasm comprising all three germ cell layers (ectoderm, endoderm, mesoderm). As a congenital malformation or ectopia, it is distinctly different from the trauma or iatrogenic development of an encephalocele. Patients come to clinical attention early in life (usually at birth or within the first few months), with a firm ...
The development of pancreatic tissue outside the confines of the main gland, without anatomic or vascular connections between them, is a congenital abnormality referred to as heterotopic pancreas. A heterotopic pancreas in the gastrointestinal tract is usually discovered incidentally and the risk of its malignant transformation is extremely low. In this study, we describe the first case of endoepithelial carcinoma arising in a gastric heterotopic pancreas of a 56-year old woman in Greece. She presented with epigastric pain, periodic nausea and vomiting. Esophagogastroduodenoscopy revealed an ulcerated lesion in the gastric antrum, biopsies of which showed intense epithelial dysplasia with incipient malignant degeneration. The pathology report of the distal gastrectomy specimen demonstrated a 2 cm in diameter ulcerative mass in the gastric antrum. Microscopically, an endoepithelial (in situ) carcinoma of the gastric antrum was determined, which in places turned into an microinvasive endomucosal
Ectopic pancreatic tissue, also known as heterotopic pancreatic tissue, refers to the presence of pancreatic tissue in the submucosal, muscularis or subserosal layers of the luminal gastrointestinal tract outside the normal confines of the pancre...
Introduction: Heterotopias, which are also referred to as choristomas and ectopias, are characterized by the presence of normal-appearing tissue in an anatomical location in which they are normally not found. Clinicopathological aspects of Heterotopias of the Head and neck from our institute is presented in this study. Materials and methods: This study is conducted in a tertiary care center for Head and neck diseases. The Heterotopic lesions occurring in head and neck reported between 2008 and 2016 were included in the study. 24 cases of Head and neck heterotopias were identified. Clinical findings, radiological, cytological and histopathological aspects were analysed. Results: Heterotopias constituted 0.17% of all head and neck lesions. A total of 24 cases of heterotopias were analysed. Thyroid heterotopias constituted majority, 13 cases (54.16%). There were 5 cases of Glial heterotopias (20.83%), 3 Salivary gland heterotopias (12.5%), 2 gastric heterotopias (8.33%) (one single tissue type and ...
Pancreatic heterotopia (PH) is defined as ectopic pancreatic tissue outside the normal pancreas and its vasculature and duct system. Most frequently, PH is detected incidentally by histopathological examination. The aim of the present study was to analyze a large single-center series of duodenal PH with respect to the clinical presentation. A prospective pancreatic database was retrospectively analyzed for cases of PH of the duodenum. All pancreatic and duodenal resections performed between January 2000 and October 2015 were included and screened for histopathologically proven duodenal PH. PH was classified according to Heinrichs classification (Type I acini, ducts, and islet cells; Type II acini and ducts; Type III only ducts). A total of 1274 pancreatic and duodenal resections were performed within the study period, and 67 cases of PH (5.3%) were identified. The respective patients were predominantly male (72%) and either underwent pancreatoduodenectomy (n = 60); a limited pancreas resection with
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췌장과 비장 내 낭성 병변은 방사선학적 영상검사로 진단이 비교적 쉬운 편이나, 췌장 내 부비장에서 발생한 유표피 낭종은 특이적 방사선 소견이 없어 진단하기 매우 어려워 췌장 내 낭성 종양으로 오진되기가 쉽다. 췌장 내 부비장 조직이 상대적으로 많다면, 종괴의 고형 성분이 복부 전산화 단층촬영 검사에서 비장과 비슷한 조영증강을 보이고 자기공명영상 검사에서 비장과 같은 신호 변화를 보인다는 점에서 방사선학적 영상검사로 췌장 내 부비장의 유표피 낭종을 진단 할 수 있다. 하지만 부비장 조직이 많지 않으면 정확한 진단은 매우 힘들며 본 증례에서도 수술 후 절제 조직에서 부비장 조직이 상대적으로 적게 관찰되었으며 이로 인해서 수술 전 영상검사로 정확한 진단은 할 수 없었다. 췌장 내 낭종이 있을 경우 감별진단을 해야 하는 질환으로 ...
In a retrospective study, 37 male and 19 female inbred laboratory mice, from 1 to 36 weeks of age, were diagnosed with lipomatous hamartomas or choristomas from nearly 10,000 mice examined at necropsy over a 24-month period. Hamartomas and choristomas were found to be rare, noninherited tumor-like conditions that occurred spontaneously in 18 inbred strains of mice with a predominance of the conditions in the C3H/HeJ and C57BL/6J strains. Prevalence between strains ranged from 0.6 to 6.2 cases per hundred thousand mice. The 56 cases studied had soft, raised masses that arose on the dorsal midline, primarily above the sutures of the skull. The lesions were prominent on gross examination due to abnormally long hair, change in direction of the hairs, and a change in hair color compared to the normal pelage. Microscopically, the masses consisted of normal adipose tissue in the reticular dermis and subcutis that sometimes extended through the cranial sutures, entering the brain, or expanding
ear a bony deficit with consequent herniation of brain tissue into the middle ear should be ruled out [53]. Three cases of heterotopic brain tissue in the middle ear associated with cholesteatoma have been reported [62]. It is possible that in all three, brain herniation occurred as a result of inflammatory damage to the tegmen tympani. Spontaneous herniations of brain (encephaloceles) may occur into the middle ear through a congenital deficiency of the tegmen or other sites [47].. A case of sebaceous choristoma of the middle ear has been described [82].. Was this article helpful?. ...
Lawson R. Thoracoabdominal duplication cyst containing heterotopic gastric mucosa: report of a case. J Am Osteopath Assoc 1968;67(11):1292. doi: .. Download citation file:. ...
Heterotopic gastric mucosa in the gall bladder is extremely unusual. It was first described by Egyedi in 1934.7 Since then it has been reported in various organs and sites in the gastrointestinal tract, including the tongue,1oesophagus,2 epiglottis,3 small bowel,4 vermiform appendix,5rectum,3 6 and gall bladder.7-17 24-34 A survey of the world literature revealed 45 reports, including the present cases, and interestingly none shared the broad spectrum of clinical and histological findings of our cases.. There is a wide range in patient age, clinical presentation and symptoms, and roentgenographic and pathological findings. From the six extended reviews,6 9 12 15 16 34 it is apparent that the sex distribution is approximately equal with a slight female preponderance, with an age range of 6-77 years (most patients being ⩽30 years). Most patients have upper quadrant abdominal pain, often of a colicky type, or vague discomfort that may be postprandial and accompanied by nausea, vomiting or, in ...
Yang, X.; Guo, K., 2013: Massive lower gastrointestinal bleeding from Meckel's diverticulum with heterotopic pancreas: case report and a brief review of the literature
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TY - JOUR. T1 - Horseshoe shaped ectopic cervical thymus extending into the anterior mediastinum. AU - Cioffi, Ugo. AU - De Simone, Matilde. AU - Nosotti, Mario. AU - Bellaviti, Nadia. AU - Radice, Ferdinando. AU - Santambrogio, Luigi. PY - 2000. Y1 - 2000. UR - http://www.scopus.com/inward/record.url?scp=0034051243&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0034051243&partnerID=8YFLogxK. M3 - Article. C2 - 10890552. AN - SCOPUS:0034051243. VL - 166. SP - 508. EP - 510. JO - European Journal of Surgery, Acta Chirurgica. JF - European Journal of Surgery, Acta Chirurgica. SN - 1102-4151. IS - 6. ER - ...
The 14.5% prevalence of IPs revealed in this study is the highest ever reported as an English full text of a clinical study, to the best of our knowledge. But some studies report prevalences close to this, 10% by Borhan-Manesh et al. [18], 11% by Weickert et al. [27], 12% by Chung et al. [30] using narrow band imaging, 13% by Vesper et al. [33] and 14% by Kumagai et al. [23]. In an abstract, Ohara et al. [52] report even 21%, also using narrow band imaging. The same prevalence of 21% was yielded by an autopsy series of infants and children [53]. In contrast, in the retrospective part of our study, the prevalence was low (0.5%), within the range of previously reported retrospective studies (0.18 to 1.6%) [13, 17, 34-41]. The discrepancy between retrospective and prospective studies is a clear indication that retrospective data comprise endoscopies in which IPs were often overlooked or neglected.. Nevertheless, IP should be looked for, and, if present, mentioned in examination reports. IP may give ...
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Kidney - Ectopic tissue, Adrenal gland in a young Sprague-Dawley rat. A well-demarcated subcapsular lesion (arrow) is diagnosed as an ectopic adrenal gland. (Image provided courtesy of Dr. Johnson Thomas, Dow Chemical USA ...
It is very unusual of an ectopic thyroid to be presented as a submental swelling, clinically mimicking a submental cyst. Suspicious of the disease with complete clinical, biochemical and radiological...
Mullerianosis is a rare choristoma of Mullerian-derived tissues. It differs from endometriosis in that at least two types of Mullerian-derived tissue is present. The pathogenesis of Mullerianosis is not completely understood, but the majority of...
Ectopic pancreas is a benign congenital abnormality, defined as pancreatic tissue that lacks anatomic or vascular continuity to the pancreas. An incidence of 0.55%-13% ha..
Aberrations of p53 occur in most, if not all, human cancers. In breast cancer, p53 mutation is the most common genetic defect related to a single gene. Immortalized human mammary epithelial cells resemble the earliest forms of aberrant breast tissue growth but do not express many malignancy-associated phenotypes. We created a model of human mammary epithelial tumorigenesis by infecting hTERT-HME1 immortalized human mammary epithelial cells expressing wild-type p53 with four different mutant p53 constructs to determine the role of p53 mutation on the evolution of tumor phenotypes. We demonstrate that different mutant/wild-type p53 heterozygous models generate loss of function, dominant negative activity, and a spectrum of gain of function activities that induce varying degrees of invasive potential. We suggest that this model can be used to elucidate changes that occur in early stages of human mammary epithelial tumorigenesis. These changes may constitute novel biomarkers or reveal novel ...
Dickkopf-1 (Dkk1), which inhibits canonical Wnt/β-catenin signaling by binding to the Wnt coreceptors LDL-related protein 5 (LRP5) and LRP6 through its carboxy-terminal cysteine-rich domain (C1), induces heart and head cell fates in Xenopus laevis embryos more potently than do other Wnt antagonists, suggesting that it may have additional roles. Korol et al. report that the amino-terminal cysteine-rich domain (N1) of Dkk1 is required for its maximal induction of cell fate and functions independently of canonical Wnt signaling. Overexpression of Dkk1 alone induces ectopic cement gland, the most anterior structure in the embryo, and heart tissues in embryos, and co-overexpression of Dkk1 with a truncated receptor that inhibits bone morphogenetic protein signaling induces the formation of a secondary body axis. When tested in these overexpression assays, the N1 domain did not induce ectopic tissues, the C1 domain induced some ectopic tissues, and N1 + C1 induced more ectopic tissues than C1 alone ...
A 38-year old woman being investigated for abdominal pain was found to have a small umbilicated lesion in the gastric antrum. Biopsies revealed it to be ectopic pancreatic tissue, a purely coincidental finding ...
We recently identified Eml1, a protein binding to microtubules, mutated in subcortical heterotopia (SH) featuring many mis-positioned neurons in the white matter (Kielar* Phan Dinh Tuy*, in press). Eml1s role in cortical development was never previously studied and little is known about the biochemical pathways in which it acts. We study Eml1 in mouse neuronal progenitors and post-mitotic neurons and question novel mechanisms leading to SH (Project 1). Defects in the CNTNAP2 gene, coding for the adhesion protein Caspr2, have also recently been characterized in a wide and expanding spectrum of neurodevelopmental disorders, including cortical dysplasia-focal epilepsy syndrome (CDFE)5 and autism6. Caspr2 is well-known for its roles in axo-glial contacts at the Nodes of Ranvier7, but its neurodevelopmental functions are little-studied. We question molecular and cellular functions of Caspr2 during neuronal migration and synaptogenesis, and the consequences of CNTNAP2 variants identified in patients ...
Our proposal addresses some of the solutions to the development of complex 3- dimensional tissue models and a new paradigm by using lymph node as in vivo biorea...
Software Packages for Holonomic Gradient Method. The numerical evaluation of the normalizing constant for a given statistical distribution is a fundamental problem in statistics. For example, the normalizing constant of the Gaussian distribution is expressed in terms of a rational expression of a parameter of the distribution named as the standard deviation. However, normalizing constants of many interesting stasistical distributions do not have such closed expressions. The holonomic gradient method, HGM in short, is a general method to evaluate normalizing constant numerically for several parameters in the framework of Zeilbergers holonomic systems approach. In fact, broad classes of normalizing constants are holonomic functions with respect to parameters. Then, such normalizing constants satisfy holonomic systems of linear partial differential equations. The HGM consists of three steps for a given normalizing constant. (1) Find a holonomic system satisfied by the normalizing constant. We may use
Polymicrogyria (PMG) and periventricular nodular heterotopia (PNH) are two developmental brain malformations that have been described independently in multiple syndromes. Clinically, they present with epilepsy and developmental handicaps in both children and adults. Here we describe their occurrence together as the two major findings in a group of at least three cortical malformation syndromes. We identified 30 patients as having both PNH and PMG on brain imaging, reviewed clinical data and brain imaging studies (or neuropathology summary) for all, and performed mutation analysis of FLNA in nine patients. The group was divided into three subtypes based on brain imaging findings. The frontal-perisylvian PNH-PMG subtype included eight patients (seven males and one female) between 2 days and 10 years of age. It was characterized by PNH lining the lateral body and frontal horns of the lateral ventricles and by PMG most severe in the posterior frontal and perisylvian areas, occasionally with ...
PubMedID: 23151899 | Periventricular nodular heterotopia on prenatal ultrasound and magnetic resonance imaging. | Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology | 8/1/2013
CONTEXT: Acute pancreatitis in ectopic pancreatic tissue is an uncommon cause of acute abdominal pain and can be difficult to diagnose on imaging. Our aim is to raise awareness and aid in the diagnosis of this entity by highlighting helpful dynamic contrast-enhanced MRI imaging findings. CASE REPORT: We report a 51-year-old man with acute onset epigastric pain presented to ER. With the presence of elevated serum lipase, the clinical diagnosis of acute pancreatitis was made. Contrast enhanced CT demonstrated normal pancreas and a focal mass at the duodenojejunal flexure, mimicked a neoplasm. Subsequent dynamic contrast enhanced MR images demonstrated enhancement pattern of the lesion similar to the native pancreatic tissue enhancement, a finding raised the possibility of acute pancreatitis in ectopic pancreatic tissue, but tumor was not excluded. Finally, patient undergone surgical bowel resection including the suspected mass that was proved as an ectopic pancreatic tissue on microscopic examination.
The butterfly effect is defined as "the sensitive dependence on initial conditions, where a small change at one place in a deterministic nonlinear system can result in large differences to a later state." In medicine, the identification of a rare disease or a genetic mutation may provide insights that spread well beyond the initial discovery.. And in genetics, scientists are learning just how widespread the effects are for mutations in one gene: filaminA (FLNA).. FLNA is a common cause of periventricular nodular heterotopia (PVNH), a disorder of neuronal migration during brain development. The syndrome was first described by the late Peter Huttenlocher, MD, and the gene was identified by Christopher Walsh, MD, PhD, of Boston Childrens Hospital.. In normal brain development, neurons form in the periventricular region, located around fluid-filled ventricles near the brains center, then migrate outward to form six onion-like layers. In PVNH, some neurons fail to migrate to their proper position ...
Empty right scrotal sac noted. Right testis is superficial to rectus muscle. It is located near lateral margin of right rectus muscle. Cord entering the testis is noted. Right testis is upside down. Right testis is smaller than left. No fo...
OP28 The complement component C3 is expressed by the endometrial ectopic tissue and is involved in the endometriotic lesion formation C. Agostinis 1, G. Zito 1, D. De Santo1, R. Vidergar2, O. Radillo 1, F. Bossi 1, S. Zorzet2, G. Ricci 1, R. Bulla 2 1 Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy 2 Department of Life Sciences, University of Trieste, Trieste, Italy E-mail address: [email protected] (C. Agostinis). Background: The complement (C) system is one of the major components of humoral innate immunity, acting as the first lines of defence against microbes. The principal roles of C system are the opsonization and lysis of pathogens, but new roles in inflammatory and immunological processes are emerging. It is involved in numerous inflammatory diseases, such as SLE, PNH and endometriosis (EM). Several groups have been demonstrated that the glandular epithelial cells found in endometriotic implants produce and secrete the C component C3. The aim ...
CONCLUSIONS: We report the clinical and mutation spectrum as well as MR imaging for a large cohort of 47 patients with Filamin A associated PVNH including two adult males. Our data are reassuring in regard to psychomotor and cognitive development, which is within normal range for the majority of patients. However, a concerning median diagnostic latency of 17 to 20 years was noted between seizure onset and the genetic diagnosis, intensely delaying appropriate medical surveillance for potentially life threatening cardiovascular complications as well as genetic risk assessment and counseling prior to family planning for this X-linked dominant inherited disorder with high perinatal lethality in hemizygous males. ...
Since the observation that malformed brain structure is associated with intractable forms of epilepsy, there has been a great deal of interest in trying to understand the function of dysplastic neurons. Here we performed experiments to investigate the influence of GABAergic inhibition on hippocampal heterotopic neurons in an animal model of malformation-associated epilepsy, e.g., rats exposed to MAM in utero. Our main findings in these animals include the following: (1) an alteration in the decay kinetics of evoked and spontaneous IPSCs recorded on heterotopic neurons, (2) "normal" inhibitory responses for heterotopic neurons after exogenous GABA application, (3) an inability to alter IPSC decay kinetics when heterotopic neurons are exposed to GABA transport inhibitors, and (4) a low level of GAT expression in heterotopic cell regions. Together, these results suggest altered inhibitory synaptic function at heterotopic synapses in the MAM model.. Abnormal electrical discharges, the hallmark of ...
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My 3 yr and 11 month old son just had an MRI for tethered spine. This came up negative but was positive for tonsillar ectopia. He has asthma and is currently taking Nasonex, Albuterol inhaler as needed, and Pulmicort Nebs at night. He also has Dx of ADHD, ODD, and Bi-polar. Can you explain what tonsillar ectopia (mild) is, does it need treatment, what are our treatment options, could any of his mental dxs be from this finding? There isnt much on the internet about this so if you could just expand on this in general, any information would be helpful. Thank you for your time ...
If you are adding the driver to the current insurance then it would cost 300$.It depends on the policies of the insurance companies and it also depends on your state.Same is the case with the California state.The insurance policy in Texas regarding the new driver would be same as above.I hope my answer will help you ...
CORRESPONDENCE. Kebble or quibble?. Dear Aunt Ethel,. To those skilled at matters surgical, a lost orchid is the euphemism for an ectopic testis or undescended testicle. Makes Tretchikoffs originals/collectors pieces sound like priceless balderdash, perhaps?. Yours affectionately. Robert-Ian Caldwell. Hilton, KwaZulu-Natal ...
Dr. Friedlander responded: Not quite, but..... An accessory spleen is something that one person in four is born with, or that can happen if the splenic capsule is torn and some of the pulp is released. If this happened at the time that an injury formed the |a href="/topics/colonic" track_data="{
Question - Face hitting steering wheel. Have seizure like spells, not able to focus. MRI shows heterotopia. Can these be treated with medicine?. Ask a Doctor about when and why MRI is advised, Ask a Neurologist
Aphanitic Singularity [abstrakt Alisa Andrasek + Netochka Nezvanova All possible branches are real (Borges, J.L. The Garden of Forking Paths) Gardens were always optimistic reflections of the world, the liminal spaces between the known and unknown, matter and aether. Foucault describes gardens as the oldest form of heterotopias, a microcosm of species, the smallest parcel of the world in its totality: The heterotopia is capable of juxtaposing in a single real place several spaces, several sites that are in themselves incompatible ... the oldest example of these heterotopias that take the form of contradictory sites is the garden. Shifting away from millennia old, rigid and static instrumentalities of control on the one side and fictional representational effects on the other, this paper discusses genware, a computational system employing dynamically relational assemblages for analysis, synthesis and cataloguing of regional folkloric and cultural artifacts phenotypes into a library of ...
Most of us are born with two ureters, one to drain the urine from each kidney into the bladder. But some babies are born with 2 ureters that drain a single kidney. In these cases, one ureter drains the upper part of the kidney and the second ureter drains the lower part of the kidney. As long as they both enter the bladder, this extra ureter is usually not a problem.
Lesions within Mist1KO pancreatic tissue contain cells that coexpress the Mist1 locus and duct cell markers. (A and B) Immunohistochemistry with CK-20-specifi
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مرحبا بكم في شبكة جامعة بابل الالكترونية لتحميل المحاضرات والبحوث الاكاديمية في موقع الكلية او الاطلاع على لوحة اعلانات الطلاب ونتائج الامتحانات اتبع الروابط في الصفحة الرئيسية لموقع الكلية ضمن شبكة جامعة بابل
A Triad of Congenital Diaphragmatic Hernia, Meckels Diverticulum, and Heterotopic Pancreas. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Periventricular nodular heterotopia (PNH) is a disorder of cortical development [1]. PNH is a term used to describe the collections of neurons lining the lateral ventricles that have failed to migrate normally to form the cerebral cortex [1]. It is a clinically and genetically heterogeneous group of disorders [2]. Mutations in the filamin A gene (FLNA) result in an X-linked dominant form of this disorder [3]. Mutations in FLNA leading to protein truncation are the predominant cause of the PNH phenotype [2, 4]. Most affected females present with seizures and normal to mildly impaired cognitive function [2, 5]. FLNA-associated PNH may also be associated with other cerebral malformations as well as extra-cerebral features [6]. The condition typically results in prenatal lethality or a more severe phenotype in males although paternal transmission has been documented in the literature [2, 7-9].. Mutations in FLNA are associated with a wide spectrum of disorders including the otopalatodigital syndrome ...