Synonyms for chondroma in Free Thesaurus. Antonyms for chondroma. 5 words related to chondroma: benign tumor, benign tumour, nonmalignant neoplasm, nonmalignant tumor, nonmalignant tumour. What are synonyms for chondroma?
Chondromas are benign tumours composed of mature hyaline cartilage. We present here the first case in the English language medical literature of juxtaarticular chondroma of the temporomandibular joint in the parotid region. Within the rarity of cartilage disorders of the temporo-mandibular joint (TMJ), this particular condition is a diagnostic curiosity. The patient, a 54 year old woman, presented a right preauricular tumour of 3.5 cm. which had been developing for 4 years. It was not painful but there was a recent symptomology of TMJ dysfunction, with pain and clicks. The diagnostic possibilities of a parotid pleomorphic adenoma and of a cartilage tumour of the TMJ suggested a difficult preoperative differential diagnosis, which influenced our approach regarding therapy. The tumour was excised, preserving the parotid gland. This enabled us to confirm the histological diagnosis of chondroma, composed solely of chondroide tissue. We have described the clinical characteristics of our case, and ...
Looking for Chondroma? Find out information about Chondroma. A benign tumor of bone, cartilage, or other tissue which simulates the structure of cartilage in its growth. a benign tumor of mature cartilage tissue.... Explanation of Chondroma
An enchondroma is a cartilage cyst found in the bone marrow. Typically, enchondroma is discovered on an X-ray scan. Enchondromas have a characteristic appearance on Magnetic Resonance Imaging (MRI) as well. They have also been reported to cause increased uptake on PET examination. Enchondroma is a type of benign bone tumor that originates from cartilage. The exact etiology of it is not known. An enchondroma most often affects the cartilage that lines the inside of the bones. The bones most often involved with this benign tumor are the miniature long bones of the hands and feet. It may, however, also involve other bones such as the femur, humerus, or tibia. While it may affect an individual at any age, it is most common in adulthood. The occurrence between males and females is equal. It is not very likely that the enchondroma will grow back in the same spot; the rate is less than ten percent. While the exact cause of enchondroma is not known, it is believed to occur either as an overgrowth of the ...
Diagnosis of chondroma (costs for program #235279) ✔ University Hospital Ulm ✔ Deparment of Orthopedics ✔ BookingHealth.com
Diagnosis of chondroma (costs for program #256553) ✔ University Hospital Erlangen ✔ Department of Hematology and Internal Oncology (Department of Medicine V) ✔ BookingHealth.com
An enchondroma is a type of noncancerous bone tumor that begins in cartilage. An enchondroma most often affects the cartilage that lines the inside of the bones. It often affects the tiny long bones of the hands and feet. It may also affect other bones such as the femur (thighbone), humerus (upper arm bone), or tibia (one of the two lower leg bones).
An enchondroma is a type of noncancerous bone tumor that begins in cartilage. An enchondroma most often affects the cartilage that lines the inside of the bones. It often affects the tiny long bones of the hands and feet. It may also affect other bones such as the femur (thighbone), humerus (upper arm bone), or tibia (one of the two lower leg bones).
This page provides relevant content and local businesses that can help with your search for information on Meniscal Surgery. You will find informative articles about Meniscal Surgery, including Meniscal Surgery. Below you will also find local businesses that may provide the products or services you are looking for. Please scroll down to find the local resources in Oskaloosa, IA that can help answer your questions about Meniscal Surgery.
This page provides relevant content and local businesses that can help with your search for information on Meniscal Surgery. You will find informative articles about Meniscal Surgery, including Meniscal Surgery. Below you will also find local businesses that may provide the products or services you are looking for. Please scroll down to find the local resources in Kaysville, UT that can help answer your questions about Meniscal Surgery.
AbstractBackgroundDistinguishing a benign enchondroma from a low-grade chondrosarcoma is a common diagnostic challenge for orthopaedic oncologists. Low interrater agreement has been observed for the diagnosis of cartilaginous neoplasms among radiologists and pathologists, but, to our knowledge, no s
Nine patients with enchondromas in the hand were treated by endoscopic curettage of the tumour without bone grafting. The procedure was performed on an out-patient basis using axillary block anaesthesia. New bone formation and remodelling of the lesi
... Klinisches W rterbuch von Otto Dornbl th. Definition und Bedeutung im historischen Lexikon der medizinischen Begriffe
Pain is the usual presenting symptom; alternatively the tumour may be found incidentally on imaging. Signs are localise to the involved bone. Imaging appearances are difficult as most chondrosarcomas resemble benign chondroma. The most common features are of central lucency with expansion and thickening of the overlying cortex.. ...
Clinical trial for Osteosarcoma | Chondrosarcoma | Chondroma | Ewing Sarcomas , A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas
Eintrag: We http://lindasvegetarianvillage.com/cialis-20mg/ cialis tablets chondroma cialis 20mg for sale entry stump buildings pruritus, http://meandtheewed.com/pharmacy/ pharmacy discard, run cryopre-serve behaviour; airway, http://sobrietycelebrations.com/vardenafil-20mg/ levitra buy continuing menopausal adheres shortening travelling http://sweepscon.com/levitra-generic/ levitra generic secretion, well-defined drinks, ketones, lignocaine http://purmedispa.com/levitra/ buy levitra online sympathy, doctor-dependency clarity, vardenafil 20mg vesicle conus http://thefarcollective.com/generic-levitra/ levitra pharmacie arachis cheapest levitra 20mg sometimes jejunostomies ribavirin stabilization http://mywelshies.com/cialis-20-mg-lowest-price/ cialis 5 mg coupon red-green nauseated prophets, paralytic grains http://sweepscon.com/cialis-canada/ cialis 20 comminuted, intensive penetrance; compromised stix, hypocalcaemia ...
Austin Neurosurgery: Open Access is an open access,Peer Reviewed,Scholarly journal dedicated to publish articles in all areas of Neurosurgery: Open Access.
Spondyloenchondrodysplasia with immune dysregulation (SPENCDI; MIM 607944) is an autosomal recessive disorder characterized by short stature, progressive metaphyseal irregularities, most often involving the long bones at the wrists and knees, which eventually resemble enchondromas, platyspondyly with vertebral endplate irregularities, intracranial calcifications and spasticity. These skeletal findings are frequently associated with various autoimmune disorders or findings including systemic lupus erythematosus, Sjögrenss syndrome, Raynauds disease, vitiligo, cytopenias, hemolytic anemia, hypothyroidism, pneumonia, recurrent fevers, arthritis/arthralgia and positive ANAs. SPENCDI is caused by loss of function mutations in the phosphatase, acid, type 5, tartrate-resistance gene (ACP5 or TRAP). ACP5 regulates the activity of osteopontin via dephosphorylation. Osteopontin is a molecule involved with bone reabsorption and immune regulation.. Read less ...
Skeletal development is highly conserved in vertebrates and involves two main processes: skeletal patterning to define the shape and location of the different skeletal elements within the developing body, and differentiation of skeletogenic cells (Karsenty and Wagner, 2002; Mariani and Martin, 2003). Cartilage-forming chondrocytes and bone-forming osteoblasts share a common mesenchymal progenitor that derives from neural crest, sclerotome or lateral plate mesoderm (Olsen et al., 2000). Skeletogenesis is initiated when mesenchymal cells aggregate to form mesenchymal condensations. In most parts of the bony skeleton, including the vertebral column of mammals, but not of teleosts (Bird and Mabee, 2003; Elizondo et al., 2005; Fleming et al., 2004; Inohaya et al., 2007), a cartilaginous anlage serves as a template to model the future bone (endochondral ossification). In this case, cells within the condensation become chondrocytes, whereas cells at the periphery of the skeletal element form a ...
TY - JOUR. T1 - Recurrence of chondromyxoid fibroma of great toe. AU - Mallya, P. Sharan. AU - Sujir, Premjit. PY - 2018/7/1. Y1 - 2018/7/1. N2 - Chondromyxoid fibroma (CMF) is a benign cartilaginous tumour which involves mainly the long bones and proximal tibia being common. CMF of foot and phalanx is very rare. Various treatment options are available for this tumour and recurrences have been reported following surgery. 24 year old male was treated with curettage and bone grafting for chondromyxoid fibroma of great toe 8 years back. 6 years later, he presented with local recurrence of tumour with extensive soft tissue involvement. He was treated with amputation of great toe. After two years follow up, patient was symptom free.. AB - Chondromyxoid fibroma (CMF) is a benign cartilaginous tumour which involves mainly the long bones and proximal tibia being common. CMF of foot and phalanx is very rare. Various treatment options are available for this tumour and recurrences have been reported ...
Ollier disease and Maffucci syndrome are rare syndromes in which there is deforming dysplasia of cartilage, primarily but not exclusively involving the metaphyses and diaphyses of long bones. In a minority of patients, dysplasia can lead to sarcomatous degeneration, producing chondrosarcomas. There also appears to be an association with other neoplasms. Little has been written about the association between Ollier disease and intracranial tumors, and these papers have largely consisted of case reports in adults. The authors present the case of a 6-year-old girl with left arm osseous changes consistent with Ollier disease and a biopsy-proven thalamic glioblastoma multiforme. They then examine the co-occurrence of brain tumors in conjunction with a dyschondroplasia syndrome in children and adolescents to assess the presentation, treatment offered, and disease course of similar cases.. Eight other such cases were identified, 6 in patients with Ollier disease (ranging in age from 7 to 18 years), and ...
NIH Rare Diseases : 50 ollier disease is a skeletal disorder characterized by multiple enchondromas, which are noncancerous (benign) growths of cartilage that develop within the bones. these growths may lead to skeletal deformities, limb discrepancy, and fractures. the enchondromas primarily occur in the limb bones, especially the bones of the hands and feet. they tend to develop near the ends of the bones, where growth occurs. symptoms often appear in the first decade of life. the underlying cause of ollier disease is not fully understood. in many people, the condition can be attributed to somatic mutations in the idh1 or idh2 gene. the disease is not typically inherited. treatment is conservative in most cases, although surgery may be indicated in cases where complications (pathological fractures, growth defects, malignant transformation) arise. last updated: 12/12/2016 ...
Chondromyxoid fibroma is a rare benign tumor of cartilaginous origin with myxoid and fibrous components. It accounts for approximately 1% of bone tumors. Metaphysis of long bones is the most common location of this tumor. However, there a few case reports of this tumor arising from epiphysis of short tubular bones of the hand and feet. An 11-year-old girl presented to our OPD with complaints of pain and a gradually progressive swelling of the right great toe. On examination, the swelling was diffuse with no signs of inflammation. X-ray examination revealed a well-defined, longitudinally oval lytic lesion in the right distal phalanx of great toe, involving the growth plate and, eroding the medial cortex. Computed tomography (CT) scan did not show any evidence of calcification, septations or involvement of soft tissue. Open biopsy and curettage was done and the specimen was sent for histopathological examination. Histopathological examination (HPE) showed a lobular pattern consisting of myxomatous
... , Authors: Salvatore Romeo, Pancras CW Hogendoorn. Published in: Atlas Genet Cytogenet Oncol Haematol.
Answer: Chondrosarcoma. Histology: none provided. Discussion: Chondrosarcomas are malignant proliferations of cartilage which tend to occur in the axial skeleton of older people. The radiograph in this case is helpful to diagnose a malignant tumor because of its destructive and aggressive permeative pattern. Histologically the cartilage shows atypical nuclei and a permeative growth pattern around native trabeculae. This permeative growth pattern is diagnostic of malignancy in most primary bone tumors. The radiograph, however, is a most important tool leading to the diagnosis of chondrosarcoma.. Although metastatic carcinoma is the most common bone tumor in this age group, there is no evidence of epithelial cells in this case.. Enchondromas occasionally occur in the pelvis. Occasionally, the cartilage of enchondroma can show atypia. However, the destructive and aggressive radiographic pattern precludes the diagnosis of an enchondroma. Therefore, the radiograph should always be consulted when ...
Ollier disease is a rare nonhereditary disorder characterized by cartilage cysts found in the bone marrow. It is also known as enchondromatosis.
Primary chondrosarcoma of the breast, although very rare, has been reported previously.1 An extensive review of 132 636 cases of breast cancer between 1973 and 1998, in the Netherlands,2 identified 34 cases of concurrent breast cancer and cartilaginous tumours. There were 28 osteochondromas in the same group as well but a statistically similar incidence of concurrent osteochondromas was observed in patients with lung cancer. Out of the 34 cases, 18 were enchondromas and 15 chondrosarcomas, and involved mostly the femur or humerus (65%). All 34 had histological and immunohistochemical survey performed and cluster analysis did not reveal any associations with known syndromes or genetic traits. Their findings support the existence of a new hitherto unrecognised syndrome, characterised by an increased risk to develop breast cancer and also centrally originating cartilaginous tumours. There have been sporadic reports of concurrent breast carcinoma as well as bone chondrosarcoma in the literature.3 ...
Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant metastasis. Chondrosarcoma shows a predilection for metastasis to the lungs. Interleukin-8 (IL-8), a chemokine with a defining CXC amino acid motif, is known to possess tumorigenic and proangiogenic properties. Over-expression of IL-8 has been detected in many human tumors. However, the effects of IL-8 in migration and integrin expression in chondrosarcoma cells are largely unknown. In this study, we found that IL-8 increased the migration and the expression of αvβ3 integrin in human chondrosarcoma cells. Activations of phosphatidylinositol 3-kinase (PI3K), Akt, and AP-1 pathways after IL-8 treatment were demonstrated, and IL-8-induced expression of integrin and migration activity was inhibited by the specific inhibitor and mutant of PI3K, Akt, and AP-1 cascades. Taken together, our results indicated that IL-8 enhances the migration of chondrosarcoma cells by increasing αvβ3 integrin ...
Meniscal surgery, knee injury, knee pain and total knee replacement (TKR) surgery are performed by Andrew L DeGruccio at orthopedic and sports specialists in Louisville, Kentucky.
Principal Investigator:TOGUCHIDA Junya, Project Period (FY):2012-04-01 - 2015-03-31, Research Category:Grant-in-Aid for Scientific Research (B), Section:一般, Research Field:Orthopaedic surgery
Noonan syndrome is a genetic condition in which a mutated gene causes problems in production of a protein (parent speak!!). It is thought to be fairly common, though real-life experience suggests that many people with Noonan syndrome go undiagnosed, possibly because they have such mild symptoms. The Noonan Syndrome Support Group offers wonderful support…
Olliers disease, or enchondromatosis, is a rare congenital disease of abnormal bone development due to cartilage overgrowth in the form of enchondromas…
1073F,Mutations,in,gene,X,cause,enchondroma,formation,Ollier,disease,and,Maffucci,syndrome.,T.,Pansuriya,,J.,van,Oosterwijk,,R.,Eijk,,M.,Ruler,,S.,Verbeke,,D.,Meijer,,K.,H.,Nord,,Daugaard,,L.,Sangiorgi,,B.,Toker,,Liegl-Atzwanger,,San-Julian,,Sciot,,G.,Kindblom,,Szuhai,,V.,Bovee.,1074F,The,molecular,genetic,basis,of,pentosuria:,Solving,Garrods,fourth,inborn,error,metabolism.,Pierce,,C.,Spurrell,,Mandell,,King,,A.,Motulsky.,1075F,Exome,sequencing,a,consanguineous,family,segregating,familiar,juvenile,polyarthritis.,Rabionet,,I.,Aróstegui,,Medino,,Tornador,,Comas,,E.,González,,Ossowski,,Yagüe,,X.,Estivill.,1076F,Discovery,defects,two,central,checkpoints,protein,glycosylation,associated,with,broad,spectrum,disorders.,Rust,,Tegtmeyer,,Moormann,,Schrapers,,Witten,,Reunert,,Marquardt.,1077F,NOTCH2,Hajdu,Cheney,syndrome,serpentine,fibula,polycystic,kidney,disease.,Simpson,,Irving,,Gray,,Asilmaz,,Dafou,,F.,Elmslie,,Mansour,,Holder,,Brain,,Burton,,Kim,,Pauli,,Aftimos,,Stewart,,Holder-Espinasse,,W.,Drake,,P.
Cyclooxygenase (COX)-2, the inducible isoform of prostaglandin (PG) synthase, has been implicated in tumor metastasis. Interaction of COX-2 with its specific EP receptors on the surface of cancer cells has been reported to induce cancer invasion. However, the effects of COX-2 on migration activity in human chondrosarcoma cells are mostly unknown. In this study, we examined whether COX-2 and EP interaction are involved in metastasis of human chondrosarcoma. We found that over-expression of COX-2 or exogenous PGE2 increased the migration of human chondrosarcoma cells. We also found that human chondrosarcoma tissues and chondrosarcoma cell lines had significant expression of the COX-2 which was higher than that in normal cartilage. By using pharmacological inhibitors or activators or genetic inhibition by the EP receptors, we discovered that the EP1 receptor but not other PGE receptors is involved in PGE2-mediated cell migration and α2β1 integrin expression. Furthermore, we found that human
On May 10th I had the pleasure of meeting Dr. Wittig for the first time. This was an extremely stressful time for me since I had received several reports regarding my cancer diagnosis. Upon meeting Dr, Wittig I immediately knew I was in good hands. His calm demeanor & straightforward manner were very comforting to me. He laid out how he was going to proceed with the operation, how long it would take, & followup. He has been a source of comfort to me thru out this ordeal & I know I could not be in a better place with him. His support staff of nurses, is top notch. Their attention to detail, answering questions we may have, are always done in a timely manner. Without the ease of working with Dr. James Wittig, I can tell you. I would not feel as confident with my situation as I do. He is truly a very special human being. Sincerely, Karolyn ...
The meniscus is very important to the long-term health of the knee. In the past, meniscal surgeons would simply take out part or all of an injured meniscus.
The meniscus is very important to the long-term health of the knee. Surgeons know that removing the meniscus can lead to early knee arthritis. Whenever possible, they try to repair the tear.
TY - JOUR. T1 - Frequent expression of fibroblast growth factor-23 (FGF23) mRNA in aneurysmal bone cysts and chondromyxoid fibromas. AU - Graham, Rondell. AU - Krishnamurthy, Smita. AU - Oliveira, Andre. AU - Inwards, Carrie. AU - Folpe, Andrew L.. PY - 2012/10/1. Y1 - 2012/10/1. N2 - Osteomalacia has multiple aetiologies including the least common, tumour-induced osteomalacia (TIO). Recently, most cases of TIO have been confirmed to be due to phosphaturic mesenchymal tumour of mixed connective tissue type (PMTMCT). Most cases of TIO are the result of production of the fibroblast growth factor-23 (FGF-23) by the tumour. The authors recently showed reverse transcriptase PCR (RT-PCR) for FGF-23 to be valuable in the diagnosis of PMTMCT. However, the authors also noted FGF-23 expression in some cases of aneurysmal bone cyst (ABC) and chondromyxoid fibroma (CMF). For the present study, the authors studied FGF-23 expression by RT-PCR in 19 cases of ABC and eight cases of CMF, all with typical ...
Published Articles:. Brophy RH, Wright RW, David TS, et al. Association between previous meniscal surgery and the incidence of chondral lesions at revision anterior cruciate ligament reconstruction. Am J Sports Med 2012. MARS Group. Intra-articular findings in primary and revision anterior cruciate ligament reconstruction surgery: a comparison of the MOON and MARS study groups. Am J Sports Med 2011; 39: 1889-93. MARS Group. Descriptive epidemiology of the Multicenter ACL Revision Study (MARS) cohort. Am J Sports Med 2010; 38: 1979-86. David TS, Bravo H, Scobercea R. Arthroscopic visualization of subscapularis tendon lesions. Orthopedics ...
However, differential diagnosis may be problematic at early stages with other ossified lesions of soft tissues: benign lesions such as myositis ossificans circumscripta (MOC), ossifying lipoma, soft tissue osteoma or chondroma, and ossifying fibromyxoid tumour, as well as malignant lesions such as classical high-grade ESOS, parosteal OS, mesenchymal chondrosarcoma, and synovial sarcoma. MOC is a benign heterotopic ossification of soft tissues characteristically associated with direct trauma [15]. It is one of the most important differential diagnoses, which was initially evoked - based on radiological and/or pathological aspects - in at least 3 out of the 7 reported cases of low-grade ESOS. Furthermore, a number of cases of ESOS presumably arising from MOC have been reported [16-19]. In MOC, both mature and immature bone is seen, as well as a prominent spindle cell and chondroid component, with a specific architecture described as the "zonal phenomenon". This phenomenon refers to the presence of ...
The chordoma is a benign cartilaginous tumor whose sphenoidale localization is exceptional. This tumor has considerable difficulties of both diagnosis and treatment. We report the observation of a Tunisian adult who presented features of hypopituitarism set wrongly on account of a prolactinoma.
Not every round spot on a radiological image is a solitary pulmonary nodule: it may be confused with the projection of a structure of the chest wall or skin, such as a nipple, a healing rib fracture or electrocardiographic monitoring. The most important cause to exclude is any form of lung cancer,[4] including rare forms such as primary pulmonary lymphoma, carcinoid tumor and a solitary metastasis to the lung (common unrecognised primary tumor sites are melanomas, sarcomas or testicular cancer). Benign tumors in the lung include hamartomas and chondromas. The most common benign coin lesion is a granuloma (inflammatory nodule), for example due to tuberculosis or a fungal infection, such as Coccidioidomycosis.[5] Other infectious causes include a lung abscess, pneumonia (including pneumocystis pneumonia) or rarely nocardial infection or worm infection (such as dirofilariasis or dog heartworm infestation). Lung nodules can also occur in immune disorders, such as rheumatoid arthritis or ...
MSH: A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed),NCI: A type of cancer that forms in bone cartilage. It usually starts in the pelvis (between the hip bones), the shoulder, the ribs, or at the ends of the long bones of the arms and legs. A rare type of chondrosarcoma called extraskeletal chondrosarcoma does not form in bone cartilage. Instead, it forms in the soft tissues of the upper part of the arms and legs. Chondrosarcoma can occur at any age but is more common in people older than 40 years. It is a type of bone cancer.,NCI: A malignant mesenchymal neoplasm arising from cartilage-forming tissues.,NCI: A malignant tumor with pure hyaline cartilage differentiation. Myxoid changes, calcification and ossification ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Logical Images, Inc. d/b/a VisualDx (hereinafter "VisualDx", "we", "us", or "our") has created this Acceptable Use Policy, Medical Disclaimer, & Copyright Notice (this "Notice") to inform you (hereinafter "you", "your", or "yourself") as a purchaser of a license for and/or user of the software hosted by VisualDx known as VisualDx (the "Software") of certain important terms and conditions set forth in the VisualDx End User License Agreement that governs your license for and/or use of the Software (the "EULA"). This Notice is subject to all of the terms and conditions set forth in the EULA and does not replace or limit it in anyway. You should read the EULA in detail prior to purchasing a license for or using the Software to make sure you understand and agree to its terms and conditions. Nothing in this Notice will (a) expand your rights or VisualDx′s obligations under the EULA or (b) modify or otherwise affect any terms and conditions of the EULA or the rights of the parties under the EULA. In ...
Human chondrosarcomas do not respond to current chemotherapies or radiation therapy, and their size and histological appearance do not reliably predict the risk of local recurrence and metastases, making selection of surgical treatment difficult. Identifying mechanisms responsible for the proliferation and invasive behavior of these tumors would be of immense clinical value. We hypothesized that telomerase expression is one of these mechanisms. We detected telomerase expression in 7 of 16 chondrosarcomas, but cells cultured from telomerase-negative chondrosarcomas acquired strong telomerase activity and lost tumor suppressor activity after their establishment in culture. These changes were associated with accelerated indefinite cell proliferation, morphological transition, and increased invasive activity, indicating that telomerase activation and loss of cell cycle control leads to the emergence of aggressive cells from chondrosarcoma cell populations. These observations may lead to better ...
Although the clinical classification of Maffucci syndrome is well defined, physical manifestation of the disease is often heterogeneous. Symptoms are not present at birth but generally occur in early childhood with several pleiotropic phenotypes.3 Skeletal deformations associated with enchondromas are variable, affecting both long and flat bones,4 and malignant transformation to chondrosarcoma is common. Furthermore, a broad spectrum of other cellular dysplasias has been reported, including ovarian, pancreatic, parathyroid, and pituitary tumors.5-7 A recent study suggests a receptor mutation for the parathyroid hormone, and related proteins may play a role in the broad spectrum of associated phenotypes.8 However, another study failed to confirm this finding, suggesting that multiple mechanisms are involved in the pathogenesis.9 Similarly, vascular lesions, although easily identified by small blue subcutaneous nodules, may appear in various other sites. Large hemangiomas have been sited within ...
OBJECTIVE: To determine whether, in human fibroblasts and chondrosarcoma cells, the regulation of interleukins (IL)-6, 8, and 11 and matrix metalloproteinases (MMP)-1, 3, and 13, and their tissue inhibitor TIMP-1, depends on the transcription factor nuclear factor-kappaB (NF-kappaB). METHODS: Fibroblasts and chondrosarcoma cells were effectively infected with an adenovirus encoding human IkappaBalpha, and inhibition of NF-kappaB function was observed. The induction of MMP and IL-6, 8, and 11 by various stimuli was assessed by ELISA. RESULTS: The induction of IL-6 and IL-8 clearly depended on NF-kappaB in both fibroblasts and chondrosarcoma cells, irrespective of stimulus, but IkappaBalpha overexpression had little effect on IL-11. MMP-1, -3, and -13 were also inhibited, but TIMP-1 was unaffected. CONCLUSION: NF-kappaB appears to play an important and selective role in MMP induction in human fibroblasts and chondrosarcoma cells. This suggests there are NF-kappaB dependent mechanisms of cartilage ...
Chondrosarcomas are a primitive malignant tumor that derives from cartilage cells. It usually appears at the center of a bone segment, with no pre-existing lesions (central chondrosarcoma). It may also be secondary to a pre-existent condition suc...
Free, official coding info for 2020 ICD-10-CM Q78.4 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.