Cholic acid, also known as 3α,7α,12α-trihydroxy-5β-cholan-24-oic acid is a primary bile acid that is insoluble in water (soluble in alcohol and acetic acid), it is a white crystalline substance.Salts of cholic acid are called cholates.Cholic acid, along with chenodeoxycholic acid, is one of the two major bile acids produced by the liver, where it is synthesized from cholesterol.. Get Price ...
Chemicals. [2,4-3H]cholic acid (24.5 Ci/mmol) was purchased from Amersham Biosciences (Piscataway, NJ). Folic acid, cholic acid (sodium salt), pyrimethamine, etoposide, vincristine, doxorubicin, and probenecid were obtained from Sigma Chemical Co. (St. Louis, MO). MK571 was obtained from Merck Frosst Canada (Kirkland, PQ, Canada), prostaglandin A1 from Cayman Chemicals (Ann Arbor, MI), calcein AM from Molecular Probes (Eugene, OR), and G-418 from Calbiochem-Novabiochem (San Diego, CA).. Tissue Culture. A clonal subline (C11) of CHO AA8 cells was subjected to stepwise selection with increasing concentrations of pyrimethamine, resulting in the establishment of PyrR100 cells as described previously (Assaraf and Slotky, 1993). Parental CHO AA8 cells and their PyrR100 subline were maintained as monolayer cultures at 37°C in RPMI-1640 medium containing 5% fetal calf serum (Invitrogen, Carlsbad, CA), 2.3 μM folic acid, supplemented with 2 mM glutamine, 100 μg/ml penicillin/streptomycin, and 1 mM ...
Bulk CHAPSO, CAS Number 82473-24-3 Product Code: BR1042 Other Names: 3-[(3-Cholamidopropyl)-dimethylammonio]-2-hydroxy-1-propane sulfonate Sizes: 5g,25g Pur
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html, ,H1 ALIGN=center, The Sign of the Four ,/H1, ,BR, ,H3 ALIGN=center, By ,/H3, ,H2 ALIGN=center, Sir Arthur Conan Doyle ,/H2, ,BR,,BR,,BR, ,H2 ALIGN=center, CONTENTS ,/H2, ,TABLE ALIGN=center WIDTH=80%, ,TR, ,TD ALIGN=right VALIGN=top,I  ,/TD, ,TD ALIGN=left VALIGN=top, ,A HREF=#chap01,The Science of Deduction,/A,,/TD, ,/TR, ,TR, ,TD ALIGN=right VALIGN=top,II  ,/TD, ,TD ALIGN=left VALIGN=top, ,A HREF=#chap02,The Statement of the Case,/A,,/TD, ,/TR, ,TR, ,TD ALIGN=right VALIGN=top,III  ,/TD, ,TD ALIGN=left VALIGN=top, ,A HREF=#chap03,In Quest of a Solution,/A,,/TD, ,/TR, ,TR, ,TD ALIGN=right VALIGN=top,IV  ,/TD, ,TD ALIGN=left VALIGN=top, ,A HREF=#chap04,The Story of the Bald-Headed Man,/A,,/TD, ,/TR, ,TR, ,TD ALIGN=right VALIGN=top,V  ,/TD, ,TD ALIGN=left VALIGN=top, ,A HREF=#chap05,The Tragedy of Pondicherry Lodge,/A,,/TD, ,/TR, ,TR, ,TD ALIGN=right ...
Variables: dissolved_oygen dissolved_organic_carbon electric_conductivity pH Substances: 1-(3-Trifluoromethylphenyl)-piperazine (KKIMDKMETPPURN-UHFFFAOYSA-N) 1-Propanesulfonate (KCXFHTAICRTXLI-UHFFFAOYSA-N) Filter Results ...
Variables: dissolved_oygen total_organic_carbon pH Substances: 1-(3-Chlorophenyl)-piperazin (VHFVKMTVMIZMIK-UHFFFAOYSA-N) 1-(3-Trifluoromethylphenyl)-piperazine (KKIMDKMETPPURN-UHFFFAOYSA-N) 1-Propanesulfonate (KCXFHTAICRTXLI-UHFFFAOYSA-N) Filter Results ...
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At one point, you were just an undifferentiated, single cell. You are now made of many cells; some of these cells function as liver cells, some as muscle
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This chapter introduces Part II (Chaps. 9- 11), which covers the biological background complementing the mathematical background given in Part I (Chaps. 2- 8). This introductory chapter is mainly...
Information for Cholic acid 81-25-4 including Cholic acid CAS NO 81-25-4, Cholic acid Suppliers, Cholic acid Manufacturers, related products of Cholic acid.
1-Propanesulfonic acid 5284-66-2 NMR spectrum, 1-Propanesulfonic acid H-NMR spectral analysis, 1-Propanesulfonic acid C-NMR spectral analysis ect.
Cholic acid is a bile acid. Bile acids are produced naturally in the body to aid in digestion of fats and certain nutrients. People with bile acid disorders are unable to produce cholic acid normally. This can make it harder for the body to absorb nutrients important for health, growth, and body functioning. Abnormal...
Global Cholic Acid Market Report gives latest insights that includes market sales, share and growth in key regions for their top manufacturers with forecast research for the Cholic Acid Industry.
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Creative-Proteomics offer cas 81-25-4 CHOLIC ACID (2,2,4,4-D4, 98%). We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
Following the isolation of a viable cell preparation, hepatocytes were maintained in monolayers for up to 24h. During this period hepatocytes were shown to maintain their viability and to synthesise and secrete bile salts, as determined by radioimmunoassay of conjugated cholic, chenodeoxycholic and ß-muricholic acids. The rate of synthesis of these bile salts by hepatocytes was increased by feeding rats cholestyramine for at least 5 days prior to the preparation of hepatocyte monolayers ...
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History The rodent magic size can be used to review cosmetic nerve injury commonly. practical deficit subsequent cosmetic nerve repair and transection inside a rodent magic size. Strategies Adult rats had been split into group 1 (settings) and group 2 (experimental). Group 1 pets underwent mind fixation accompanied by a cosmetic nerve damage and functional Read More. ...
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Cholic (?), Cho*linic (?), a. [Gr. , from bile.] Physiology|Physiol. Chemistry|Chem. Pertaining to, or obtained from, the bi...
Subcellular localization of 3 alpha, 7 alpha-dihydroxy- and 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoyl-coenzyme A ligase(s) in rat liver ...
View Notes - Chap_19 from CHEM 102 at UMBC. Chapter 19 Solubility and Simultaneous Equilibria In this chapter we extend our discussion of ionic equilibria to deal with salts that until now we have
View Chem102-Chap_14 from CHEM 102 at Los Angeles Mission College. tion of H2? 19 Chemistry 102 Chapter 14 CALCULATIONS INVOLVING QUADRATIC EQUATIONS · Some of the problems invo lving equilibrium
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एक दिन बात चली passion की तो उन्हें याद आया कि अपने ज़िन्दगी में पहली फिल्म शूटिंग जो उन्होंने देखी थी वो थी मुग़ल-ए-आज़म की. वो बच्चे ही थे जब उनके पिताजी (जो बंबई में वकील हुआ करते थे) उन्हें प्यार किया तो डरना क्या गाने की शूटिंग और शीशमहल दिखाने ले गए थे. उन्होंने थोडा उदास हो के कहा वो एक हद्द थी जिस तक हम कभी नहीं गए. फिर एक बार उन्होंने बताया कि कैसे जब अमिताभ बच्चन को पहली फिल्म की तनख्वाह ...
TY - CHAP. T1 - Testing of Materials. AU - Pluijm, van der, R.. AU - Vermeltfoort, A.T.. PY - 1997. Y1 - 1997. N2 - No abstract.. AB - No abstract.. M3 - Chapter. SN - 9054106808. SP - 4. EP - 45. BT - Structural Masonry : an experimental/numerical basis for practical design rules. A2 - Rots, J.G.. PB - Balkema. CY - Rotterdam. ER - ...
TY - CHAP. T1 - Obesitas. AU - Bosch, J.D.. AU - Daansen, P.J.. PY - 2006. Y1 - 2006. M3 - Chapter. SP - 303. EP - 320. BT - Psychologie en Geneeskunde: Behavioural Medicine. A2 - Kapitein, A.A.. A2 - Beunderman, R.. A2 - Dekker, J.. A2 - Vingerhoets, A.J.J.M.. PB - Bohn Stafleu Van Loghum. CY - Houten. ER - ...
Dec 22, 2005. SAN DIEGO, CA - Dec 22, 2005 - Diazyme Laboratories, a company that applies its proprietary enzyme technologies to develop low cost and high quality diagnostic products for clinical and research uses, announced today that the U.S. Food and Drug Administration (FDA) has granted Diazyme 510(K) clearance to market its Enzymatic Total Bile Acids (TBA) Assay Kit for the quantitative determination of total bile acids in human blood samples.. Total bile acids is a well known bio-marker for diagnosis of liver diseases. Serum total bile acids are elevated in patients with acute hepatitis, chronic hepatitis, liver sclerosis, and liver cancer. Total bile acids levels are found to be the most sensitive indicator for monitoring the effectiveness of interferon treatment of chronic hepatitis C patients. Moreover, total bile acids tests are also widely used to screen pregnant women for the condition of obstetric cholestasis, a disease that is caused by elevated total bile acids in the bloodstream ...
Bile acid synthesis, determined by conversion of [4-14C]cholesterol into bile acids in rat and human hepatocytes and by measurement of mass production of bile acids in rat hepatocytes, was dose-dependently decreased by cyclosporin A, with 52% (rat) and 45% (human) inhibition of 10 microM. The decreased bile acid production in rat hepatocytes was due only to a fall in the synthesis of beta-muricholic and chenodeoxycholic acids (-64% at 10 microM-cyclosporin A), with no change in the formation of cholic acid. In isolated rat liver mitochondria, 26-hydroxylation of cholesterol was potently inhibited by the drug (concn. giving half-maximal inhibition = 4 microM). These results suggest that cyclosporin A blocks the alternative pathway in bile acid synthesis, which leads preferentially to the formation of chenodeoxycholic acid. ...
View drug interactions between cholic acid and deoxycholic acid. These medicines may also interact with certain foods or diseases.
Hyocholic acid is a bile acid. Bile acids are steroid acids found predominantly in the bile of mammals. The distinction between different bile acids is minute, depending only on the presence or absence of hydroxyl groups on positions 3, 7, and 12. Bile acids are physiological detergents that facilitate excretion, absorption, and transport of fats and sterols in the intestine and liver. Bile acids are also steroidal amphipathic molecules derived from the catabolism of cholesterol. They modulate bile flow and lipid secretion, are essential for the absorption of dietary fats and vitamins, and have been implicated in the regulation of all the key enzymes involved in cholesterol homeostasis. Bile acids recirculate through the liver, bile ducts, small intestine and portal vein to form an enterohepatic circuit. They exist as anions at physiological pH and, consequently, require a carrier for transport across the membranes of the enterohepatic tissues. The unique detergent properties of bile acids are ...
Bile acid in the stomach plays a key role in the digestion of food in the small intestine. Two chief bile acids produced in the body include chenodeoxycholic acid and cholic acid. These acids assist in the creation of micelles, which aids in breaking down dietary fat, and is integral for the digestion of fat in the small intestine. Bile acid is a fluid secreted by the hepatocytes that flows into the canaliculi. From the canaliculi, it reaches the bile ducts, and is then transferred to the gall bladder where it is concentrated with time and the addition of other bodily fluids. Bile acids are derived from the cholesterol inside of the hepatocytem, and are made up of hydrophilic or polar faces and lipid or hydrophobic faces. Cholesterol gets converted into chenodeoxycholic and cholic acids, which are two forms of bile acid. These are combined with amino acids and released into the canaliculi. This combined nature of bile acids enables them to perform two of the most important functions in the ...
27-Hydroxycholesterol (27OH) is a strong suppressor of cholesterol synthesis and a weak activator of LXR in vitro. The regulatory importance of 27OH in vivo is controversial. Here we utilized male mice with increased levels of 27OH either due to increased production (CYP27A1 transgenic mice) or reduced metabolism (Cyp7b1-/- mice). We also used mice lacking 27OH due to a knockout of Cyp27a1. The latter mice were treated with cholic acid to compensate for reduced bile acid synthesis. The effects of the different levels of 27OH on Srebp- and other LXR-regulated genes in the liver were investigated. In the liver of CYP27tg mice we found a modest increase of the mRNA levels corresponding to the LXR target genes Cyp7b1 and Abca1. A number of other LXR-regulated genes were not affected. The effect on Abca1 mRNA was not seen in the liver of Cyp7b1-/- mice. There were little or no effects on cholesterol synthesis. In the liver of the Cyp27-/- mice treated with 0.025% cholic acid there was no significant ...
A metabolic disorder results when an enzyme responsible for the breakdown of our food is defective which results in compounds, also known as metabolites, accumulating in blood or urine. Incorrect metabolism means your body might have too much or too little of a metabolite which can have detrimental impacts on normal growth and development.. For cholestasis of pregnancy patients: qualitative urine bile acids is not the first-line test for the diagnosis/monitoring of cholestasis of pregnancy. Serum total bile acids should be performed in preference. VCGS does not perform serum total bile acids testing.. ...
Description: A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent ...
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
Creative-Proteomics offer cas 83-44-3 DEOXYCHOLIC ACID (2,2,4,4-D4, 98%). We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
Using deoxycholic acid as starting materials, a series of 12a-aza-C-homo-12-one 7-deoxycholic acid derivatives were synthesized The antiproliferative activity of the synthesized compounds against some carcinoma cell lines was investigated. The results showed that some 12-oxy-12a-aza-C-homo-7-deoxycholic acid derivatives displayed distinct cytotoxicity to HeLa (human cervical carcinoma) and Tu 686 (laryngocarcinoma) tumor ...
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3alpha,7alpha-Dihydroxy-5beta-cholestane + [Reduced NADPH---hemoprotein reductase] + Oxygen ,=, 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane + [Oxidized NADPH---hemoprotein reductase] + ...
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What think you of this sentence, my dear Lizzy? -- said Jane as she finished it. ``Is it not clear enough? -- Does it not expressly declare that Caroline neither expects nor wishes me to be her sister; that she is perfectly convinced of her brothers indifference, and that if she suspects the nature of my feelings for him, she means (most kindly!) to put me on my guard? Can there be any other opinion on the subject?. ``Yes, there can; for mine is totally different. -- Will you hear it?. ``Most willingly.. ``You shall have it in few words. Miss Bingley sees that her brother is in love with you, and wants him to marry Miss Darcy. She follows him to town in the hope of keeping him there, and tries to persuade you that he does not care about you.. Jane shook her head.. ``Indeed, Jane, you ought to believe me. -- No one who has ever seen you together, can doubt his affection. Miss Bingley I am sure cannot. She is not such a simpleton. Could she have seen half as much love in Mr. Darcy for ...
TY - CHAP. T1 - Occupying cheek by jowl - property issues arising from communal living. AU - Clarke, DN. PY - 1998. Y1 - 1998. M3 - Chapter in a book. SN - 0198764545. SP - 337. EP - 405. BT - Law & Land - Themes and Perspectives. A2 - Bright, S.. A2 - Dewar, J. PB - Oxford University Press. ER - ...
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