MalaCards based summary : High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 6, is also known as high density lipoprotein cholesterol level qtl6. An important gene associated with High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 6 is SCARB1 (Scavenger Receptor Class B Member 1 ...

Triglycerides (TG)/high-density lipoprotein (HDL) cholesterol ratio is a marker of small/dense low-density lipoprotein particles, which are closely associated with various metabolic and vascular diseases. However, the role of TG/HDL cholesterol ratio in cerebrovascular diseases has not been well studied. In this study, we evaluated the relationship between TG/HDL cholesterol ratio and the presence of silent brain infarct (SBI) in a neurologically healthy population. We retrospectively evaluated consecutive participants in health check-ups between January 2006 and December 2013. SBI was defined as an asymptomatic, well-defined lesion with a diameter of ≥3 mm on T1- or T2-weighted images. TG/HDL cholesterol ratio was calculated after dividing absolute TG levels by absolute HDL cholesterol levels. Of 3172 healthy participants, 263 (8.3%) had SBI lesions. In multivariate analysis, TG/HDL cholesterol ratio was independently associated with SBI (adjusted odds ratio [aOR] = 1.16, 95% confidence interval [CI]

Triglycerides (TG)/high-density lipoprotein (HDL) cholesterol ratio is a marker of small/dense low-density lipoprotein particles, which are closely associated with various metabolic and vascular diseases. However, the role of TG/HDL cholesterol ratio in cerebrovascular diseases has not been well studied. In this study, we evaluated the relationship between TG/HDL cholesterol ratio and the presence of silent brain infarct (SBI) in a neurologically healthy population. We retrospectively evaluated consecutive participants in health check-ups between January 2006 and December 2013. SBI was defined as an asymptomatic, well-defined lesion with a diameter of ≥3 mm on T1- or T2-weighted images. TG/HDL cholesterol ratio was calculated after dividing absolute TG levels by absolute HDL cholesterol levels. Of 3172 healthy participants, 263 (8.3%) had SBI lesions. In multivariate analysis, TG/HDL cholesterol ratio was independently associated with SBI (adjusted odds ratio [aOR] = 1.16, 95% confidence interval [CI]

TY - JOUR. T1 - Effectiveness of low-dose crystalline nicotinic acid in men with low high-density lipoprotein cholesterol levels. AU - Martin-Jadraque, Raquel. AU - Tato, Federico. AU - Mostaza, Jose M.. AU - Vega, Gloria L. AU - Grundy, Scott M. PY - 1996/5/27. Y1 - 1996/5/27. N2 - Background: Hypoalphalipoproteinemia (low serum concentration of high-density lipoprotein cholesterol [HDL-C]) is a common pattern of dyslipidemia associated with coronary heart disease. High doses of nicotinic acid effectively raise HDL-C levels in this condition, but they are commonly accompanied by side effects. The efficacy of low doses of nicotinic acid that may produce fewer side effects has not been adequately studied. Objective: To determine the effects of low-dose nicotinic acid on HDL-C levels in patients with hypoalphalipoproteinemia. Methods: Forty-four men with low HDL-C levels (, 1.03 mmol/L [,40 mg/dL]) entered the study. Twenty-four patients otherwise had normal lipid levels, and 20 were moderately ...

TY - JOUR. T1 - High density lipoprotein cholesterol levels are an independent predictor of the progression of chronic kidney disease. AU - Baragetti, A.. AU - Norata, G. D.. AU - Sarcina, C.. AU - Rastelli, F.. AU - Grigore, L.. AU - Garlaschelli, K.. AU - Uboldi, P.. AU - Baragetti, I.. AU - Pozzi, C.. AU - Catapano, A. L.. PY - 2013/9. Y1 - 2013/9. N2 - Objectives: Patients with chronic kidney disease (CKD) often present with reduced plasma HDL cholesterol (HDL-C) levels. Whether this reduction in an epiphenomenon or is involved in disease progression is unclear. The aim of this study was to investigate the relation between HDL-C levels/function and CKD progression in patients with different degrees of disease. Design: A total of 176 patients with CKD [glomerular filtration rate (GFR) 50.3 ± 29.1 mL min-1] were recruited and followed for up to 84 months. Lipid profile, metabolic status and kidney function were evaluated at predetermined times. Age-matched control subjects were selected from ...

Dive into the research topics of Patient-level discordance in population percentiles of the total cholesterol to high-density lipoprotein cholesterol ratio in comparison with low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol: The very large database of lipids study (VLDL-2B). Together they form a unique fingerprint. ...

METHODS AND RESULTS During a mean follow-up of 9 months (range, 7-11 months), 28 (41%) patients developed restenosis. A low high density lipoprotein (HDL) cholesterol level was independently and strongly related to both the risk of restenosis (p less than 0.001) and to the time of restenosis (p = 0.03). The mean HDL cholesterol level was 33 +/- 12 mg% in the restenosis group compared with 45 +/- 12 mg% in the nonrestenosis group (p less than 0.001). Restenosis developed in 22 of 34 (64%) patients with an HDL cholesterol less than or equal to 40 mg% compared with six of 34 (17%) patients with an HDL cholesterol greater than 40 mg% (p less than 0.002). The only other variable that was significantly related to restenosis was a low PAI-1 level (p = 0.04). ...

TY - JOUR. T1 - The predictive role of serum triglyceride to high-density lipoprotein cholesterol ratio according to renal function in patients with acute myocardial infarction. AU - Korea Acute Myocardial Infarction Registry Investigators. AU - Kim, Jin Sug. AU - Kim, Weon. AU - Woo, Jong Shin. AU - Lee, Tae Won. AU - Ihm, Chun Gyoo. AU - Kim, Yang Gyoon. AU - Moon, Joo Young. AU - Lee, Sang Ho. AU - Jeong, Myung Ho. AU - Jeong, Kyung Hwan. AU - Ahn, Young Keun. AU - Chae, Sung Chull. AU - Kim, Jong Hyun. AU - Hur, Seung Ho. AU - Kim, Young Jo. AU - Seong, In Whan. AU - Choi, Dong Hoon. AU - Chae, Jei Keon. AU - Hong, Taek Jong. AU - Rhew, Jae Young. AU - Kim, Doo Il. AU - Chae, In Ho. AU - Yoon, Jung Han. AU - Koo, Bon Kwon. AU - Kim, Byung Ok. AU - Lee, Myoung Yong. AU - Kim, Kee Sik. AU - Hwang, Jin Yong. AU - Cho, Myeong Chan. AU - Oh, Seok Kyu. AU - Lee, Nae Hee. AU - Jeong, Kyoung Tae. AU - Tahk, Seung Jea. AU - Bae, Jang Ho. AU - Rha, Seung Woon. AU - Park, Keum Soo. AU - Kim, Chong ...

The average increase in high density lipoprotein concentrations of 3.99 mg/dl for an intake of 30 g of alcohol a day would be associated with a risk reduction of 13.5% (4.3% to 24.2%) among men in the physicians health study29; a similar reduction of 13.3% (10.6% to 15.9%) would be expected on the basis of results from the lipids research clinics study.32 If we adjust the effect estimate for intraindividual variability in high density lipoprotein cholesterol concentrations20 we estimate a 16.8% reduction in risk of coronary heart disease directly attributable to increased high density lipoprotein cholesterol concentration from consuming 30 g of alcohol a day Because the effect of alcohol on high density lipoprotein cholesterol concentration was stronger in those with lower baseline concentrations the predicted 5.09 mg/dl increase for those with an average concentration of 35 mg/dl would lower the risk of coronary heart disease by 20.9% after adjustment for intraindividual variability. Because ...

TY - JOUR. T1 - Inverse Association of High-Density Lipoprotein Cholesterol Concentration with Muscle Mass in Children. AU - Duran, Ibrahim. AU - Martakis, Kyriakos. AU - Schafmeyer, Leonie. AU - Jackels, Miriam. AU - Rehberg, Mirko. AU - Schoenau, Eckhard. PY - 2019/9/17. Y1 - 2019/9/17. KW - children. KW - fat mass. KW - HDL cholesterol. KW - muscle mass. KW - reference centiles. KW - CARDIOVASCULAR RISK-FACTORS. KW - X-RAY ABSORPTIOMETRY. KW - FAT-FREE MASS. KW - BODY-COMPOSITION. KW - CENTILE CURVES. KW - SERUM-LIPIDS. KW - ADIPOSITY. KW - POPULATION. KW - OBESITY. KW - AGE. U2 - 10.1089/chi.2019.0122. DO - 10.1089/chi.2019.0122. M3 - Article. VL - 15. SP - 476. EP - 484. JO - Childhood obesity. JF - Childhood obesity. SN - 2153-2168. IS - 7. ER - ...

TY - JOUR. T1 - High-density lipoprotein cholesterol. T2 - a potential therapeutic target for prevention of coronary artery disease.. AU - Chernobelsky, Alexander. AU - Ashen, M. Dominique. AU - Blumenthal, Roger S.. AU - Coplan, Neil L.. PY - 2007/1/1. Y1 - 2007/1/1. N2 - High-density lipoprotein cholesterol has an important role in the pathophysiology of coronary artery disease. High-density lipoprotein cholesterol is becoming an increasingly important prognostic and therapeutic target. The purpose of this paper is to review the biochemical pathways involved in reverse cholesterol transport and to discuss potential, clinically based high-density lipoprotein therapies that may contribute to reduction in risk of atherosclerosis.. AB - High-density lipoprotein cholesterol has an important role in the pathophysiology of coronary artery disease. High-density lipoprotein cholesterol is becoming an increasingly important prognostic and therapeutic target. The purpose of this paper is to review the ...

Abstract BACKGROUND: Compared to whites, insulin-resistant African Americans have worse outcomes. Screening programs that could identify insulin resistance early enough for intervention to affect outcome often rely on triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) levels. Racial differences in TG and HDL-C may compromise the efficacy of these programs in African Americans. A recommendation currently exists to use the TG/HDL-C ratio ≥2.0 to predict insulin resistance in African Americans. The validity of this recommendation needs examination. Therefore, our aim was to determine the ability of TG/HDL-C ratio to predict insulin resistance in African Americans. METHODS: In 1,903 African Americans [895 men, 1,008 women, age 55 ± 12 years, mean ± standard deviation (SD), range 35-80 years, body mass index (BMI) 31.0 ± 6.4 kg/m(2), range 18.5-55 kg/m(2)] participating in the Jackson Heart Study, a population-based study of African Americans, Jackson, Mississippi tricounty region,

Fifty-five healthy, sedentary, nonsmoking, and nonobese 24- to 26-year-old men who had low plasma concentrations of high density lipoprotein (HDL) cholesterol were selected for a study of the effect of short-term exercise on plasma lipid and lipoprotein concentrations. The participants were randomized into two groups. Of these, 28 were assigned to a 9-week program of submaximal aerobic exercise three times weekly, and 27 were assigned to a nonexercising control group. Changes in physical fitness were assessed by increments in estimated maximal oxygen consumption; this increased by 15% in the exercise group (p less than 0.001) but remained unchanged in the control group. During the study, body weights and skinfold thicknesses of both groups remained essentially unchanged after 9 weeks. There was no significant difference between the trial groups in total cholesterol, HDL cholesterol, calculated low density lipoprotein cholesterol, or in the HDL2 and HDL3 subfractions. Triglyceride levels were ...

Introduction: Low level of high density lipoprotein-cholesterol (HDL-C) has been identified as a residual risk of cardiovascular events after lowering low density lipoprotein-cholesterol (LDL-C) in patients with stable coronary artery disease. Further, high HDL-C level is proven to have a protective effect for cardiovascular events in primary prevention studies.. Hypothesis: We assessed the hypothesis that we evaluated whether the HDL-C level may have predictive and protective value in patients with acute myocardial infarction (MI) who had percutaneous coronary intervention (PCI) and statin treatment.. Methods: A total of 15,938 patients who had PCI and statin treatment were selected from the Korean Myocardial Infarction registry. According to the ATP III criteria, baseline HDL-C level was used to identify patients with low HDL-C (,40 mg/dL, Group A), normal HDL-C (≥40 to , 60 mg/dL, Group B), or high HDL-C (≥60 mg/dL, Group C). Major adverse cardiac events (MACE) at one-year, the primary ...

BACKGROUND: Triglyceride/high-density lipoprotein-cholesterol (TG/HDL-C) ratio was a surrogate marker of IR; however, the relationship of TG/HDL-C with IR might vary by ethnicity. This study aims to investigate whether lipid ratios-TG/HDL-C, cholesterol/high-density lipoprotein-cholesterol (TC/HDL-C) ratio, low-density lipoprotein-cholesterol/high-density lipoprotein-cholesterol (LDL-C/HDL-C)) could be potential clinical markers of insulin resistance (IR) and β cell function and further to explore the optimal cut-offs in a Chinese population with different levels of glucose tolerance.. METHODS: Four hundred seventy-nine subjects without a history of diabetes underwent a 75 g 2 h Oral Glucose Tolerance Test (OGTT). New-onset diabetes (n = 101), pre-diabetes (n = 186), and normal glucose tolerance (n = 192) were screened. IR was defined by HOMA-IR , 2.69. Based on indices (HOMA-β, early-phase disposition index [DI30], (ΔIns30/ΔGlu30)/HOMA-IR and total-phase index [DI120]) that indicated ...

HDL cholesterol LDL - MedHelps HDL cholesterol LDL Center for Information, Symptoms, Resources, Treatments and Tools for HDL cholesterol LDL. Find HDL cholesterol LDL information, treatments for HDL cholesterol LDL and HDL cholesterol LDL symptoms.

An increase in HDL-C level by 6% reduces the incidence of cardiovascular disease by 22-24%, which is similar to the effect of reduced LDL-C level decreasing cardiovascular disease by 28%.19,20) In addition, low HDL-C level has been blamed as the main cause of recent increasing prevalence dyslipidemia in Korea.21) Though pharmacological treatment options to increase HDL-C such as cholesterol ester transfer protein (CETP) inhibitor and apo A1 mimetic peptide are under development, basic epidemiological evidences required to define HDL-C cut-off levels are still not sufficient in Korea. If the study subjects are categorized by the NCEP ATP III guideline, 43.8% of men and 23.6% of women belong to the low HDL-C group. When the ADA guideline is used, 43.8% of men and 62.6% of women have low HDL-C group; resulting in a markedly higher prevalence of low HDL-C level in women. Musha et al.5) from Japanproposes a higher cut-off value of HDL-C of 50 mg/dL so that the prevalence of cardiovascular diseases in ...

This study aimed to estimate the relationship between various lipid abnormalities and albuminuria in hypertensive Korean adults. Data obtained from the Korea National Health and Nutrition Examination Survey in 2011 to 2012 were analyzed. The study included 2330 hypertensive participants. Total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels were measured. Dyslipidemia parameters were defined as high TG ≥200 mg/dL, low HDL-C as HDL-C ,40 mg/dL, high TC/HDL-C as TC/HDL-C ratio ≥4, high TG/HDL-C as TG/HDL-C ratio ≥3.8, and high LDL-C/HDL-C as LDL-C/HDL-C ratio ≥2.5. Albuminuria was defined as a urine albumin to creatinine ratio (ACR) ≥30 mg/g. Women with albuminuria showed significantly higher levels of TG, TC/HDL-C, and TG/HDL-C and a lower level of HDL-C than women without albuminuria (all P , 0.05). LogTG, TC/HDL-C, and logTG/HDL-C were positively correlated with ACR in both men and women; ...

Despite the long-held knowledge of an inverse relationship between plasma high-density lipoprotein (HDL) cholesterol levels and rates of cardiovascular disease (CVD) in populations, the HDL hypothesis has recently been shaken to its foundations by a barrage of controversial data. For example, clinical trials of an agent (torcetrapib) that increases HDL cholesterol by inhibiting cholesteryl ester transfer protein (CETP), an essential transferase that moves cholesterol from HDL to apolipoprotein B (apo B)-containing lipoproteins, have shown unexpected harm with increased cardiovascular events after ,1 year of treatment among subjects who were already taking protective doses of atorvastatin (1). In addition, coronary and carotid imaging studies with the same agent failed to show vascular improvements attributable to the drug or to the increase in HDL cholesterol (2,3). Moreover, genetic studies have challenged the role of HDL in atherogenesis by providing observations contrary to the dogma that HDL ...

Objective - It is stated that high-density lipoprotein cholesterol (HDL-C) levels are low in Turkish people and that this may be related to genetic factors. Low HDL-C is a parameter of the metabolic syndrome (MetS). In this study, the relationship between low HDL-C levels and MetS has been investigated. ...

5.Once the mince is starting to look like it is nearly there, put the cooked squash into a separate pan and mash with the butter until you have a smooth paste. If the mix is very wet then place over a medium heat and steam some of the water off for a few minutes while stirring continuously to prevent the squash mash from burning ...

A low plasma level of high-density lipoprotein (HDL) cholesterol (HDL-C) is associated with cardiovascular risk. A key cardioprotective property of HDL is cholesterol efflux capacity (CEC), the ability of HDL to accept cholesterol from macrophages. In this study, we aimed to identify the predictive value of CEC for cardiovascular risk. The relative risks (RRs) and 95% confidence intervals (CIs) were pooled to analyze the association between CEC and the incidence of cardiovascular events and all-cause mortality. The odds ratios (ORs) and 95% CIs were pooled to estimate the association of CEC and the prevalence of cardiovascular events. A total of 15 studies were included. Results showed that the highest CEC was significantly associated with a reduced risk of cardiovascular events incidents compared to the lowest CEC (RR, 0.56; 95% CI, 0.37 to 0.85; I 2, 89%); the pooled RR of cardiovascular risk for per unit SD increase was 0.87 (95% CI, 0.73 to 1.04; I

How Does Obesity Affect Cancer Cavity High Blood. Prozac And Teratogens Asthma International Rugby Olanzapine Fluoxetine Combination Depressive Disorder.Un taux élevé de cholestérol ne provoque généralement pas de symptômes, mais constitue un facteur de risque de maladie coronarienne.Path: Acute fibrinous organizing pneumonia (AFOP-pattern) (see also If).anti-cholesterol: escroqueries,. en raison des «effets similaires de la fluoxétine à. ou encore si vous vous sentez agité et même «high» quelques.. Rosiglitazone-fenofibrate interaction: severe paradoxical decreased high-density lipoprotein cholesterol levels. Deux antidépresseurs, la fluoxétine.Avec la fluoxétine (inhibiteur du CYP2D6), des doses uniques danti-acides (aluminium, magnésium). augmentation des taux de prolactine, de cholestérol,.. Depressive retardation and treatment with fluoxetine: assessment of the motor component. SABBE B.,. Lower serum high-density lipoprotein cholesterol ...

High-density Lipoprotein Cholesterol (HDL-C) (LabCorp). Get know how much does lab test cost. Direct access testing with or without insurance.

EDITOR, - Jane Patmore and colleagues lesson of the week raises many issues on the diagnosis and current management of lipid disorders.1 Firstly, several consensus guidelines recommend that a lipid diagnosis should be established before drug treatment is started and that the lipid profile should include measurement of the high density lipoprotein cholesterol concentration.2,3. Secondly, the case reported was complicated by many confounding factors known to influence total and high density lipoprotein cholesterol concentrations, including the administration of β blockers, prednisolone, and high dose oral hormone replacement treatment and the coexistence of renal disease (the patient had received a transplant). These factors would confuse any diagnosis of a primary hyper-(alpha)-lipoproteinaemia. The authors measured the apolipoprotein A1 concentrations, but other apolipoproteins (apolipoprotein A2 (present in high density lipoprotein) and apolipoprotein (a)/ B(sub100)) are independent risk ...

This is the first study to describe 18F-NaF uptake in the coronary arteries with PET/CT. We have demonstrated that this technique is both feasible and repeatable and that it can provide key insights into coronary artery plaque biology. Activity was higher in patients with atherosclerosis compared with control subjects, displaying a progressive rise with increasing atherosclerotic burden. Furthermore, 18F-NaF uptake can be used to discriminate between those patients with active and inactive coronary calcification. Those with active calcification (38%) were more likely to have clinically significant CAD, a higher incidence of previous MACE, lower serum high-density lipoprotein cholesterol concentrations, and higher Framingham risk prediction scores. Therefore, 18F-NaF holds promise as a means of identifying high-risk populations and refining the predictive power of CAC scoring. Finally, the spatial resolution of PET/CT allows localization of the 18-NaF signal to specific coronary territories and ...

Deedwania P, Singh V, Davidson MH. Low high-density lipoprotein cholesterol and increased cardiovascular disease risk: an analysis of statin clinical trials. Am J Cardiol. 2009 Nov 16; 104(10 Suppl):3E-9E ...

Modification of the effects of estrogen therapy on HDL cholesterol levels by polymorphisms of the HDL-C receptor, SR-BI: the Rancho Bernardo Study.

Prevalence, Predictors, and Impact of Low High-Density Lipoprotein Cholesterol on in-Hospital Outcomes Among Acute Coronary Syndrome Patients in the Middle East

|i|Obejective|/i|. To examine the discriminatory power of triglyceride (TG) and triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) for insulin resistance (IR) in a normoglycaemic Chinese population. |i|Methods|/i|. The data were collected from 711 individuals. The normoglycaemic individuals were eventually included in the study (|i|n|/i| = 533, age: 62.8 ± 6.6 years, male: 56.8%), who were with a fasting plasma glucose < 6.1 mmol/L and without a history of diabetes. IR was defined as the upper quintile (≥1.6) of homeostasis model assessment of IR. Area under the receiver operating characteristic curve (AROC) was used to examine the discriminatory power. |i|Results|/i|. The discriminatory power of TG/HDL-C for IR was acceptable in women with a BMI < 24 kg/m|sup|2|/sup| or waist circumference < 80 cm (AROCs: 0.718 and 0.713, resp.); however, the discriminatory power was not acceptable in the obese women. TG/HDL-C was not an acceptable

The novel findings of this study are as follows. First, a GGT1 variant, rs4820599, the G allele and a low HDL-C level were identified to be risk factors for a high baPWV in Japanese subjects with T2DM in the longitudinal analysis. Interestingly, a significant interactive effect of the GGT1 genotype and low HDL-C level on the risks of both a high baPWV and DR was found. Second, the HDL-C level at baseline was identified to be a significant predictor of a high baPWV only in G allele carriers according to the ROC analysis. This result in the T2DM patients was also noted in the general population. Third, the GGT1 genotype was not associated with the risk of DR, although it affected the principal factors involved in the risk of DR. Fourth, the associations between the levels of GGT and fasting plasma glucose, HDL-C and LDL-C and between dyslipidemia and a high baPWV were significant only in G allele carriers among the general subjects. In this study, the triglyceride levels were positively associated ...

Arti kata dari hdl cholesterol. Definisi dari hdl cholesterol. Pengertian dari hdl cholesterol: the cholesterol in high-density lipoproteins; the `good cholesterol; a high level in the blood is thought to lower the risk of coronary artery disease;

Obese Childhood Dyslipidemia Management Beyond Statins - MUFA, PUFA, and Sea-buckthorn Supplements. By Bogdana Virgolici, Laura Anca Popescu, Horia Virgolici, Daniela Elena Casariu, Olivia Timnea and Maria Mohora. The dyslipidemia pattern usually associated with childhood obesity consists of a combination of elevated triglyceridemia, decreased plasma high density lipoprotein cholesterol concentration and LDL-c concentration at the upper limit of the normal range. This type of dyslipidemia is associated with dense and small LDL, which are proatherogenic. High circulating levels of oxidized LDL were described in extreme pediatric obesity, in children with high fructose intake and are associated with insulin resistance. The worst effect on blood lipids have trans and saturated fatty acids. But the amount of total energy intake plays more important role in lipid profiles. In childhood obesity it seems that insulin resistance precedes the development of the metabolic syndrome feature and insulin ...

Background. Our aim was to determine whether the common variants within the coding sequence of ABCA1 gene affects low plasma high-density lipoprotein cholesterol (HDL-C) levels in Turkish patients with coronary artery disease (CAD). The study group was composed of 552 CAD patients, of which 251 had HDL-C levels 40 mg/dL. ...

Particularly noteworthy is that intake of fermented milk products such as yogurt and soured milk and cheese were associated with lower rates of fracture and mortality. Furthermore, we observed a positive association only between milk intake and markers of oxidative stress (urine 8-iso-PGF2α) and inflammation (serum interleukin 6). Previously, we found a negative relation between bone mineral density and 8-iso-PGF2α.42 63 Interleukin 6 seems to be causally related to cardiovascular disease64 and may influence bone loss and osteoporosis.65 Importantly, those who consume high amounts of non-fermented milk have a more non-favourable cardiovascular risk factor profile, with higher blood pressure, lower high density lipoprotein cholesterol levels, and higher insulin resistance.18 In contrast, intake of cheese and fermented milk products is related to higher high density lipoprotein cholesterol levels, less insulin resistance, and a lower risk of myocardial infarction.18 22 23 24 In addition, a ...

PHILADELPHIA) - The discovery that high levels of high-density lipoprotein (HDL) cholesterol (the good cholesterol) is associated with reduced risk of cardiovascular disease has fostered intensive research to modify HDL levels for therapeutic gain. However, recent findings have called into question the notion that pharmacologic increases in HDL cholesterol levels are necessarily beneficial to patients. Now, a new study from researchers at the University of Pennsylvania School of Medicine shows that a different metric, a measure of HDL function called cholesterol efflux capacity, is more closely associated with protection against heart disease than HDL cholesterol levels themselves. Findings from the study could lead to new therapeutic interventions in the fight against heart disease. The new research will be published in the January 13 issue of the New England Journal of Medicine.. Atherosclerosis, a component of heart disease, occurs with a build-up along the artery wall of fatty materials ...

Regarding high density lipoprotein (HDL) cholesterol levels, the study found that women with HDL cholesterol levels below 1.29 mmol/L (50 mg/dL) had a 10% increased risk of breast cancer compared to women with HDL cholesterol levels above 1.29 mmol/L (50 mg/dL ...

Agents that increase HDL-C via reverse cholesterol transport could provide a new therapeutic option for the prevention of atherosclerotic cardiovascular disease. The investigators propose to investigate the effects of LY518674 on components that may likely affect atherogenesis in patients with the metabolic syndrome including HDL-C metabolism and reverse cholesterol transport pathways, the inflammatory response, and oxidative stress in human subjects.. As an agonist of the nuclear peroxisome proliferator activated receptor (PPAR) alpha, LY518674 may affect the transcription of genes that encode various proteins involved in atherogenesis. This study will explore the consequences of altered transcription such as changes in messenger ribonucleic acid (mRNA) and protein levels as well as protein activity. ...

Science Daily) The discovery that high levels of high-density lipoprotein (HDL) cholesterol (the good cholesterol) is associated with reduced risk of cardiovascular disease has fostered intensive research to modify HDL levels for therapeutic gain. However, recent findings have called into question the notion that pharmacologic increases in HDL cholesterol levels are necessarily beneficial to patients. Now, a new study from researchers at the University of Pennsylvania School of Medicine shows that a different metric, a measure of HDL function called cholesterol efflux capacity, is more closely associated with protection against heart disease than HDL cholesterol levels themselves. ...

We report the case of a 55-year-old man who presented to the outpatient lipid clinic for his scheduled follow-up with severely low high-density lipoprotein cholesterol levels of new onset. Diagnostic workup showed that he was infected by visceral leishmaniasis. He was treated with liposomal amphotericin B and serum lipid levels returned to usual values.

LOW HDL CHOLESTEROL FROM GENE VARIATION NOT ASSOCIATED WITH INCREASED RISK OF ISCHEMIC HEART DISEASE CHICAGO-Lower levels of high-density lipoprotein (HDL) cholesterol due to a gene mutation is not

Sigma-Aldrich offers abstracts and full-text articles by [Kenji Okumura, Hideto Tsukamoto, Hideyuki Tsuboi, Haruo Hirayama, Haruo Kamiya, Masato Watarai, Ryoji Ishiki, Toyoaki Murohara].

Nevertheless, some aspect of treatment with intravenous agents is suggested. Further, uncircumcised men aged 4170 years, baseline cigarette smoking, serum high-density lipoprotein cholesterol as important to note that the increased dysfunction or problems in women, there are many points of view the goal of the penis and avoids reducing the level of interest in developing a therapeutic measure and, except where contraindicated, should be excluded in clinical trials. Do you use them at the base of the device and become comfortable with the levels of b-t and/or lh may be due to problems with extrusion and discomfort as compared to those seen in some men with pd experience erectile dysfunction, acquired with a single receptor, the 5-ht1b receptor is expressed as a member of a gay swim team and church allowed him to talk about personal issues and to the audience his own level of the. 7c). Intravaginal ejaculatory latency time. Prevalence and predictors of outcome data, there is a more accurate ...

When we think of good cholesterol foods, we typically think of those that will not contribute to an increase in cholesterol levels but help to lower them.

Diabetic Dyslipidaemia is a condition where a person is diabetic and has elevated levels of the total cholesterol, the bad low-density lipoprotein (LDL) cholesterol and the triglycerides and a decrease in the good high-density lipoprotein (HDL) cholesterol concentration in the blood. Optimal LDL cholesterol levels for adults with diabetes are less than 100 mg/dL, optimal HDL cholesterol levels are equal to or greater than 40 mg/dL, and desirable triglycerides levels are less than 150 mg/dL.Over 80 per cent of all diabetic patients are estimated to be suffering from diabetic dyslipidaemia. There are more than 350 million diabetics globally - so the people suffering from diabetic dyslipidaemia could be around 300 million. ...

Unclog your arteries with these ideas on how to raise HDL cholesterol levels to combat cardiovascular diseases and reduce your risk of a stroke.

TY - JOUR. T1 - ATP-binding cassette transporter A1 (ABCA1) R219K (G1051A, rs2230806) polymorphism and serum high-density lipoprotein cholesterol levels in a large Japanese population. T2 - Cross-sectional data from the Daiko study. AU - Mokuno, Junichiro. AU - Hishida, Asahi. AU - Morita, Emi. AU - Sasakabe, Tae. AU - Hattori, Yuta. AU - Suma, Shino. AU - Okada, Rieko. AU - Kawai, Sayo. AU - Naito, Mariko. AU - Wakai, Kenji. PY - 2015/4/11. Y1 - 2015/4/11. N2 - Among polymorphisms in ATP-binding cassette transporter Al (ABCA1) gene, the available evidence demonstrates that the ABCA1 R219K polymorphism (G1051A, rs2230806) K allele is associated with a higher high-density lipoprotein cholesterol (HDL- C) level and may play a protective role against coronary artery disease (CAD) risk in Asians and Caucasians. The findings from many underpowered studies from Asian countries (n=71-597), however, still remain inconsistent. The objective of this study was to overcome the limitations of previous ...

Danladi I. Musa, Samuel A. Adenirn, A. U. Dikko and Stephen P. Sayers. ​. Purpose: Examine the impact of an 8-week program of high-intensity interval training on high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC) and the atherogenic index (TC/HDL-C) in 36 untrained men ages 21 - 36.. ​. Conclusions: Findings support the recommendations of high-intensity interval training as an alternative mode of exercise to improve blood lipid profiles for individuals with acceptable physical fitness levels.. ​. IN PLAIN ENGLISH: Having high levels of HDL cholesterol can play a protective role against coronary atherosclerosis since it acts as a lipid scavenger. In past studies, continuous activity endurance training has been proven to elevate HDL-C. To also elevate HDL-C levels and protect against coronary issues, high-intensity interval training can also be used. ...

How is Non-High Density Lipoprotein abbreviated? NHDL stands for Non-High Density Lipoprotein. NHDL is defined as Non-High Density Lipoprotein rarely.

Case Report: Patient 1, a 42-year-old man with type 2 diabetes mellitus, was referred for evaluation of a very low HDL cholesterol level (Table). He had been taking insulin; troglitazone, 400 mg/d; and metformin, 850 mg/d. Gemfibrozil was initially prescribed for hypertriglyceridemia, but fenofibrate, 201 mg, was then substituted. When the patient was first seen, his HDL cholesterol level was 0.39 mmol/L (15 mg/dL) and his apolipoprotein A-I (apo A-I) level, 0.29 g/L, was very low. Fenofibrate therapy was discontinued, and therapy with atorvastatin, 10 mg, was started. His HDL cholesterol level increased to 1.06 mmol/L (41 mg/dL). Currently, the patient is receiving simvastatin, 20 mg/d; gemfibrozil, 600 mg twice daily; fish oil, 1 g/d; pioglitazone, 45 mg/d; metformin, 500 mg three times per day; and ramipril, 10 mg/d. His apo A-I level has increased to 1.14 g/L, and his HDL cholesterol level is 1.19 mmol/L (46 mg/dL ...

A cross-sectional study of a random sample of 976 coloureds (mixed race) of the Cape Peninsula, ages 15 to 64 years old, revealed a population with unexpectedly high levels of high density lipoprotein (HDL) cholesterol. The mean level for men was 55.4 +/- 16.1 mg/dl (SD) and for women, 60.8 +/- 16.0 mg/dl. The ratio of HDL cholesterol to total cholesterol expressed as a percentage was 26.3% +/- 9.5% for men and 28.1% +/- 9.3% for women. The HDL cholesterol levels were apparently lower than those of black and Negro populations, yet higher than those of Caucasian populations. Men with levels of HDL cholesterol above the median reported a personal history and a family history of coronary heart disease less frequently than did men with lower levels, while women with high levels of HDL cholesterol were less likely to have a history of hypertension or diabetes. Stepwise multiple regression analysis of variables significantly associated with HDL cholesterol levels showed that they explained 29.7% and ...

Frost G, Leeds A, Dore C, Madeiros S, Braading S, Dornhorst A. Glycemic index as a predictor of serum HDL-cholesterol concentration . J Am Osteopath Assoc 1999;99(4):194. doi: 10.7556/jaoa.1999.99.4.194.. Download citation file:. ...

Whats a Healthy Cholesterol Ratio?. Jan 15, The ratio of total cholesterol to HDL is an easy way to get an idea of whether your cholesterol levels are healthy. If you can achieve a healthy ratio of total cholesterol to HDL, and maintain this long-term, this can help to reduce your risk of heart problems in the future. Apr 25, How to lower your cholesterol? Get regular aerobic physical exercise. It has been proven that regular exercises increase HDL cholesterol (good) and decrease LDL cholesterol (bad). Diet. Eat foods low in fatty acids, saturated fats, and cholesterol. Dont forget to .. High cholesterol is one of the biggest risk factors for heart attack, stroke and cardiovascular disease, how to calculate total cholesterol and hdl ratio to the Cleveland Clinic. Your cholesterol ratio, which compares how to calculate total cholesterol and hdl ratio total cholesterol to your HDL, or good, cholesterol, can help better assess your risk. Heres what you need to know.. In order to understand ...

Cholesteryl ester transfer protein (CETP) is a plasma glycoprotein that promotes reverse cholesterol transport via the exchange of cholesteryl ester (CE) and triglyceride (TG) among lipoproteins. Cholesteryl ester transfer protein (CETP) promotes reverse cholesterol transport via exchange of cholesteryl ester and triglyceride among lipoproteins. CETP has a central role in lipoprotein metabolism.. CETP, a hydrophobic plasma glycoprotein, is a promising target for raising circulating HDL cholesterol (HDL-C) concentrations in humans. CETP is secreted primarily from the liver and plays a critical role in HDL metabolism by facilitating the exchange of cholesteryl esters (CE) from HDL for triglycerides (TG) in apoB-containing lipoproteins, such as LDL and VLDL.. CETP catalyses the exchange of cholesteryl ester and triglyceride between HDL and apoB containing lipoprotein particles. The role of CETP in modulating plasma HDL cholesterol levels in humans is well established and there have been significant ...

Low high-density lipoprotein cholesterol (HDL-C) disease with unknown etiology has a high prevalence in the Xinjiang Kazak population. In this study, long noncoding RNAs (lncRNAs) that might play a role in low HDL-C disease were identified. Plasma samples from 10 eligible individuals with low HDL disease and 10 individuals with normal HDL-C levels were collected. The lncRNA profiles for 20 Xinjiang Kazak individuals were measured using microarray analysis. Differentially expressed lncRNAs and mRNAs with fold-change values not less than 1.5 and FDR-adjusted P-values less than 0.05 were screened. Bioinformatic analyses, including Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and network analyses, were used to determine relevant signaling pathways and predict potential target genes. In total, 381 lncRNAs and 370 mRNAs were differentially expressed based on microarray analysis. Compared with those in healthy individuals, several lncRNAs were upregulated or downregulated in patients

TY - JOUR. T1 - Sex differences in high density lipoprotein cholesterol among low-level alcohol consumers. AU - Weidner, Gerdi. AU - Connor, Sonja L.. AU - Chesney, Margaret A.. AU - Burns, John W.. AU - Connor, William E.. AU - Matarazzo, Joseph. AU - Mendell, Nancy R.. PY - 1991. Y1 - 1991. N2 - The purpose of this study was to examine high density lipoprotein cholesterol (HDL-C) levels in a sample of community-living women and men who consumed 1 drink of alcohol/day or less. Self-reports of alcohol consumption and clinical assessments of plasma lipid and lipoprotein levels were obtained twice, at 12 months apart. Among men, consumption of 1 drink/day or less was unrelated to levels in HDL-C. In contrast, among women alcohol consumption throughout this relatively low consumption range was positively associated with HDL-C levels. These findings indicate that the association of alcohol and higher levels of HDL-C may occur at lower intakes of alcohol in women than in men.. AB - The purpose of ...

The percentage of adults aged 20 and over with high total cholesterol has declined substantially since 1999-2000. For 2009-2010, the percentage of adults with high total cholesterol was 13.4%, thus meeting the Healthy People 2010 target of 17% or less [Objective (12-14)]. Substantial and steady decreases in the prevalence of high total cholesterol among men aged 40 and over and women aged 60 and over during the 1999-2010 period resulted in achievement of the Healthy People 2010 objective in all sex and racial-and-ethnic groups and in all sex and age groups except for women aged 40 and over. For 2009-2010, only 11.9% of women compared with 31.4% of men aged 20 and over had low HDL cholesterol. The percentage with low HDL cholesterol is consistently higher in men than in women within each race and ethnicity group. Because women typically have higher HDL cholesterol levels than men, the percentage with low HDL cholesterol is expected to be lower in women than in men. The percentage of adult men ...

Ivanhoe Newswire) -- It has been well-known that high levels of high-density lipoprotein (HDL) cholesterol, the good kind, are associated with a lower risk of heart disease. Recent studies have asked if pharmacologic increases in HDL cholesterol levels are beneficial to the patient. A new study shows that a different metric, a measure of HDL function called cholesterol efflux capacity, is more closely associated with protection against heart disease than HDL cholesterol levels themselves.. Atherosclerosis typically occurs with a build-up of cholesterol along the artery wall. Cholesterol efflux capacity, an integrated measure of HDL function, is a direct calculation of the efficiency by which a persons HDL removes cholesterol from cholesterol-loaded macrophages (a type of white blood cell) -- the sort that accumulate in arterial plaque.. Recent scientific findings have directed increasing interest toward the concept that measures of the function of HDL, rather than simply its level in the ...

Prevalence of Low Levels of High-Density Lipoprotein Cholesterol (HDL-C) at Presentation in Acute Coronary Syndromes (ACS) and its Relation to In-Hospital Mortality: Results from the NCDR (R)

Background-Endothelial lipase is a phospholipase with activity against high-density lipoprotein. Although a small number of mutations in LIPG have been described, the role of LIPG in protection against atherosclerosis is unclear. Methods and Results-We identified 8 loss-of-function (LOF) mutations in LIPG in individuals with high-density lipoprotein cholesterol. Functional analysis confirmed that most rare mutations abolish lipase activity in vitro, indicating complete LOF, whereas 2 more common mutations N396S and R476W reduce activity by ≈50%, indicating partial LOF and implying ≈50% and ≈75% remaining endothelial lipase function in heterozygous complete LOF and partial LOF mutation carriers, respectively. complete LOF mutation carriers had significantly higher plasma high-density lipoprotein cholesterol levels compared with partial LOF mutation carriers. Apolipoprotein B-depleted serum from complete LOF carriers showed significantly enhanced cholesterol efflux acceptor capacity, whereas ...

BACKGROUND: Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes. METHODS: We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching

Treatment with a new drug called torcetrapib increased high-density lipoprotein (HDL; good) cholesterol in individuals with low HDL levels, as well as decreasing the levels of low-density lipoprotein (LDL; bad) cholesterol. Torcetrapib is a blocker of a cell chemical called cholesterol ester transfer protein (CETP). Individuals who do not have CETP because of a genetic defect have significantly elevated HDL levels. This discovery led to the finding that CETP inhibition may be a novel way of raising HDL, the researchers explained in the New England Journal of Medicine, April 8, 2004. The investigators treated 19 participants who had low HDL levels with an inactive placebo for 4 weeks. After 4 weeks, the participants were given another 4 weeks of either torcetrapib alone or in combination with the statin atorvastatin. The results showed a 46% HDL increase in the once-daily torcetrapib-only group and a 61% rise in the once-daily torcetrapib/atorvastatin group. The third phase of the study ...

A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol - Volume 15 Issue 6

Thesis, English, High density lipoprotein cholesterol as a predictor of clinical outcomes in patients with coronary artery disease undergoing percutaneous coronary intervention with normal initial low density lipoprotein cholesterol for Abdel mawgood Rany Elsayed

What is cholesterol?. Cholesterol is a fatty substance that is found in the blood. Cholesterol is made naturally in the body, and is also introduced to the body through the foods you eat. Most people consider cholesterol to be a bad thing, but not all cholesterol is created equal. There is actually good and bad cholesterol. To have healthy cholesterol is to have enough or a higher amount of good cholesterol, and low bad cholesterol.. Good Cholesterol. HDL (high density lipids) is also known as good cholesterol. HDL cholesterol actually helps to clean blood vessels and transport bad cholesterol out of the body.. Foods that have good cholesterol include fish, avocado, oats, some nuts, and berries. These foods can help you raise your HDL cholesterol levels and lower the bad.. Bad Cholesterol. LDL, or low density lipids is bad cholesterol. This is the kind of cholesterol that creates plaque that can clog your blood vessels and create problems such as high blood pressure, stroke and heart ...

Fifteen middle-aged, untrained (defined as no regular exercise) men (mean age 49.9 years, range 42-67) cycled on a cycle ergometer at 50 rpm for 30 min at an intensity producing 60% predicted maximum heart rate [(fc,max), where fc, max = 220 - age]. Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglyceride (Tg) concentrations were measured from fasting fingertip capillary blood samples collected at rest, after 15 and 30 min of exercise, and at 15 min post-exercise. The mean HDL-C level increased significantly from the resting level of 0.85 mmol · l-1 to 0.97 mmol · 1-1 ( ...

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When your doctor spouts off your cholesterol levels in terms of LDL and HDL, does your brain shut off? You know in the back of your mind that one is good and one is bad, but which is which? And why is one better that the other? In order to understand the difference between LDL and HDL cholesterol, you need a basic understanding of how cholesterol works with and affects your body chemistry.. First, cholesterol in itself - whether LDL or HDL cholesterol - is not a bad thing. Although cholesterol is most well known for the role it plays in contributing to heart disease, it is actually a substance needed by and naturally produced by the body. For instance, cholesterol is responsible for building cell membranes and for maintaining the fluidity of these membranes. Cholesterol also plays an important part in helping to metabolize fat-soluble vitamins such as vitamins A, D, E, and K. Scientists also say cholesterol helps in the production of bile, which, in turn, helps to digest fat. Although we hear so ...

BACKGROUND: Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes. METHODS: We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching

As we can see cholesterol performs vital functions in our body. However, there are two types of cholesterol, the good and the bad.. High-density lipoprotein cholesterol (HDL), is also known as good cholesterol. This form takes the excess from our blood and transports it to the liver so it can be removed from our body. (4). Then you have, low-density lipoprotein cholesterol (LDL), otherwise called bad cholesterol. It also transports cholesterol around the body to where it might be needed. However, as well as depositing it to repair cells it leaves excess cholesterol behind in the arteries. Very low density lipoprotein cholesterol (VLDL) is another bad form of cholesterol. When levels of this substance are high it can contribute to cardiovascular disease. Triglycerides are another fatty substance in our blood, in fact its the most common type of lipid (fat) in the body. Their role is to store excess energy we produce from our diet. VLDL is responsible for carrying triglycerides around ...

When you have a health checkup, cholesterol levels are definitely on the list to ensure that your lipid profile is at target levels. High triglyceride levels put you at risk for a number of serious health issues. The lipid profile measures the fat in your blood, and there are three types to check. The LDL or bad cholesterol, the HDL or good cholesterol and triglycerides.. Ideally, total cholesterol should be less than 200 mg/dL, HDL should be 60 mg/dL or more and triglycerides should be below 150 mg/dL. A deviation from these readings leads to the build up of unhealthy cholesterol levels resulting in blocked arteries, putting you at risk for a heart attack or stroke.. Triglycerides are a crucial source of energy in the body, but high triglyceride levels are risky for heart health. This leads to a condition called metabolic syndrome characterized by low HDL cholesterol, high blood pressure, belly fat and high blood sugar, increasing increases the risk for heart disease, stroke and ...

The joint consensus panel of the European Atherosclerosis Society (EAS) and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) recently addressed present and future challenges in the laboratory diagnostics of atherogenic lipoproteins. Total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, and calculated non-HDL cholesterol (=total - HDL cholesterol) constitute the primary lipid panel for estimating risk of atherosclerotic cardiovascular disease (ASCVD) and can be measured in the nonfasting state. LDL cholesterol is the primary target of lipid-lowering therapies. For on-treatment follow-up, LDL cholesterol shall be measured or calculated by the same method to attenuate errors in treatment decisions due to marked between-method variations. Lipoprotein(a)-cholesterol is part of measured or calculated LDL cholesterol and should be estimated at least once in all patients at risk of ASCVD, especially in those whose LDL cholesterol decline poorly upon statin ...

Ligands for peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) increase skeletal muscle fatty acid catabolism, improve insulin sensitivity, increase serum high-density lipoprotein cholesterol, elicit anti-inflammatory activity and induce terminal differentiation. Contradictory findings are also reported suggesting that PPARβ/δ ligands potentiate tumorigenesis by increasing cell proliferation, by inhibiting apoptosis through phosphorylation of Akt and by increasing cyclooxygenase-2 (COX2) and vascular endothelial growth factor (VEGF) expression. The contradictory findings could be due to differences in the model system (cancer cell line versus in vivo), differences in cell culture conditions (with and without serum) or differences in ligands. The present study examined the effect of two different PPARβ/δ ligands (GW0742 and GW501516) in human cancer cell lines (HT29, HCT116, LS-174T, HepG2 and HuH7) cultured in the presence or absence of serum and compared in vitro analysis with in ...

Title: Dyslipidemia as a Risk Factor for Ischemic Stroke. VOLUME: 9 ISSUE: 14. Author(s):Konstantinos Tziomalos, Vasilios G. Athyros, Asterios Karagiannis and Dimitri P. Mikhailidis. Affiliation:Head of Atherosclerosis and Metabolic Syndrome Units, Second Propedeutic Department of Internal Medicine, Aristotle University, Hippocration Hospital, Thessaloniki, 55 132, Greece.. Keywords:ischemic stroke, hemorrhagic stroke, statins, fibrates, nicotinic acid, low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglycerides. Abstract: Ischemic stroke is a major cause of morbidity and mortality. Whereas dyslipidemia is a major risk factor for coronary heart disease (CHD), its role in the pathogenesis of ischemic stroke is less clear. Epidemiological studies have provided conflicting findings regarding the association of dyslipidemia with ischemic stroke. Overall, elevated LDL-C levels appear to increase the risk of ischemic stroke. Low HDL-C levels also appear to be associated ...

High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases ...

Data were collected and analyzed from a cross-sectional study using the World Health Organizations STEPwise approach, to estimate the prevalence of various types of dyslipidemia and determine their associated factors among adults in Kingdom of Saudi Arabia. The study population included 4490 Saudi adults aged 15 years and older who were selected by a stratified, multistage, cluster random sampling technique. Lipid profile was determined by spectrophotometrically by biochemical methods, high total cholesterol (TC) was defined as TC of 5.2 mmol/L or more, hypertriglyceridemia as serum triglycerides level 1.7 mmol/L or more and. low high-density lipoprotein cholesterol (HDL-C) as serum HDL-C 0.9 mmol/L or less, LDL-C 3.35 mmol/L or more and TC/HDL ratio 5 or more. Of the 4490 subjects (94.4 % of total sample) included in the final analysis, 51% were females, 23% of study subjects were less than 25years and 11% were 55 or more years of age. The overall prevalence of dyslipidemia ranged from about 20% to 40

MEDICAL ANIMATION TRANSCRIPT: If you or someone you know has been diagnosed with high cholesterol, its important to understand what cholesterol is and why its important to keep it under control. Cholesterol is a fat-like substance made by your liver and also comes from foods you intake that is then packaged into particles called lipoproteins. Your body needs cholesterol to make hormones, vitamin D, and a substance that helps you digest food, called bile. This video discusses two types of lipoproteins that carry cholesterol-- low density lipid protein, or LDL cholesterol, also known as bad cholesterol, and high density lipoprotein, or HDL cholesterol, also known as good cholesterol. LDL travels through your bloodstream, delivering cholesterol to the cells that need it. If your body has too much LDL, it can build up in the walls of your arteries. LDL and other substances in your artery wall form a fatty deposit called plaque. Over time, plaque can narrow the artery and reduce blood flow. LDL ...

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These healthy choices can lower high cholesterol, and they may even end up preventing diabetes.. If your doctor has told you that you have high cholesterol levels, it may be time to take action. Having high total or bad LDL cholesterol or low good HDL cholesterol can increase risk for heart attacks and stroke, but the condition is usually treatable. Therapeutic lifestyle changes, such as diet and exercise, are the first line of defense, while medications may be necessary to lower higher levels of cholesterol or for patients who cannot lower cholesterol when they make lifestyle changes.. The following strategies can help lower high total cholesterol, LDL cholesterol, and/or triglycerides, and/or raise HDL cholesterol. As you will see, many of these choices can also help prevent diabetes if you have prediabetes or slightly high blood sugar, and Lark DPP can help you establish these choices as healthy habits.. ...

Clinical and pathologic studies have shown that elevated levels of total cholesterol (Total-C), low density lipoprotein cholesterol (LDL-C), and apolipoprotein B (ApoB - a membrane transport complex for LDL) promote human atherosclerosis. Similarly, decreased levels of HDL-cholesterol (HDL-C) and its transport complex, apolipoprotein A, are associated with the development of atherosclerosis. Epidemiologic investigations have established that cardiovascular morbidity and mortality vary directly with the level of Total-C and LDL-C and inversely with the level of HDL-C. Like LDL, cholesterol-enriched triglyceride-rich lipoproteins, including VLDL, IDL, and remnants, can also promote atherosclerosis. Elevated plasma TG are frequently found in a triad with low HDL-C levels and small LDL particles, as well as in association with non-lipid metabolic risk factors for coronary heart disease. As such, total plasma TG has not consistently been shown to be an independent risk factor for CHD. Furthermore, ...

Diet plans that are low in hydrogenated fat and cholesterol, high in fiber, and also reduced in salt are the most effective options for a healthy and balanced diet regimen. Lowering cholesterol via diet alone can lower the risk of heart diseases such as coronary artery condition (CAD) and stroke. People with hypertension need to also make an effort to keep their blood pressure reduced. Blood pressure increases the threat of creating cholesterol-related problems, so it should be managed as well. Describe How Cholesterol Buildup Can Impact Blood Flow Through Arteries. Smoking cigarettes or utilizing other tobacco items has been shown in countless researches to raise LDL cholesterol degrees and also lower HDL cholesterol levels. This is why quitting cigarette smoking is so crucial. Various other contributors to cholesterol include obesity, physical inactivity, alcohol consumption, and also the existence of various other danger elements, such as diabetes mellitus, heart problem, and cancer. ...

PubMed journal article: Exercise attenuates the increase in plasma monounsaturated fatty acids and high-density lipoprotein cholesterol but not high-density lipoprotein 2b cholesterol caused by high-oleic ground beef in women. Download Prime PubMed App to iPhone, iPad, or Android

Cholesterol is a fat-like substance in the blood. The bodys cells need cholesterol, but too much of it creates problems. Approximately two thirds of the bodys cholesterol is made and stored in the liver; the remaining cholesterol comes from diet, especially from meat, chicken, fish, and dairy products. A simple blood test measures cholesterol, and laboratory tests report 3 values: low-density lipoprotein cholesterol, called LDL; high-density lipoprotein cholesterol, called HDL; and total cholesterol, which is the sum of LDL and HDL.. LDL and HDL have very different functions, and problems occur when patients have either too much LDL or too little HDL. Think of LDL as the carriers taking cholesterol from the liver to cells. Once the cells have what they need, they refuse delivery. The carriers do not know what to do with the extra cholesterol, so they dump it in the bloodstream and return to the liver for another batch.. Now think of HDL as the clean-up crew; they travel the bloodstream hauling ...

Background: The main goal of using statins is to reduce the level of plasma cholesterol, meanwhile they have a wide spectrum of actions. Objectives: To identify the effect of statins on fractional cholesterol esterification (FCE) as well as the complete profile of lipids and (apo)lipoproteins. Design and methods: In an age and sex matched case-control study, 400 subjects who were referred for coronary angiography were divided into two groups according using statins. Results: Total cholesterol was decreased significantly following treatment with statins (165.6 38.0 mg/dL vs. 205.3 48.4, p 0.001). About 90% of the reduction was occurred in nonHDL and 10% in HDL fraction. Reduction of nonHDL cholesterol (125.2 35.2 mg/dL vs. 162.8 45.2, p 0.001) occurred on both unesterified (52.4 21.5 mg/dL vs. 65.2 25.5, p 0.001) and esterified cholesterol (74.7 27.3 mg/dL vs. 96.6 34.1, p 0.001). But the decrease in HDL cholesterol (40.4 10.0 mg/dL vs. 42.3 9.9, p 0.079) happened exclusively in unesterified ...

Principle #6: Policies at eliminating artificial trans fats in the diet - The authors expect to further reduce the level of trans fats that increase LDL cholesterol levels, lower HDL cholesterol levels that increases the risk of heart attacks. This principle requires the authors to accept the cholesterol theory of reducing heart attacks, but recent studies are debunking that theory. Take the recent high-profile NIH-sponsored AIM-HIGH trial comparing statin to statin plus niacin therapy in patients with cardiovascular disease and low HDL levels. (This study was designed to show that increasing HDL levels with niacin would improve heart attack and stroke outcomes.) This study was stopped 18 months ahead of schedule not only because it was determined to be extremely unlikely that the increase in HDL produced by niacin would improve outcomes, but also because of an unexpected increase in strokes among the patients receiving niacin, a drug known to increase HDL. Support for the results of this ...

Principle #6: Policies at eliminating artificial trans fats in the diet - The authors expect to further reduce the level of trans fats that increase LDL cholesterol levels, lower HDL cholesterol levels that increases the risk of heart attacks. This principle requires the authors to accept the cholesterol theory of reducing heart attacks, but recent studies are debunking that theory. Take the recent high-profile NIH-sponsored AIM-HIGH trial comparing statin to statin plus niacin therapy in patients with cardiovascular disease and low HDL levels. (This study was designed to show that increasing HDL levels with niacin would improve heart attack and stroke outcomes.) This study was stopped 18 months ahead of schedule not only because it was determined to be extremely unlikely that the increase in HDL produced by niacin would improve outcomes, but also because of an unexpected increase in strokes among the patients receiving niacin, a drug known to increase HDL. Support for the results of this ...

Diet plans that are reduced in saturated fat and cholesterol, high in fiber, and also reduced in salt are the best choices for a healthy diet plan. Reducing cholesterol via diet regimen alone can decrease the danger of heart problem such as coronary artery illness (CAD) and also stroke. Individuals with hypertension must additionally make an effort to keep their high blood pressure reduced. High blood pressure raises the danger of developing cholesterol-related problems, so it needs to be regulated too. Lab Corp Vap Test. Smoking cigarettes or making use of other cigarette products has been displayed in many researches to raise LDL cholesterol degrees and also lower HDL cholesterol levels. This is why giving up cigarette smoking is so crucial. Various other contributors to cholesterol include obesity, physical lack of exercise, alcohol intake, as well as the presence of various other risk elements, such as diabetic issues, cardiovascular disease, and cancer. Additionally, some drugs, including ...