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Pregnant women experience unique physiological changes that may result in clinically significant alterations in drug PKs. Unfortunately, there have been few clinical trials to study the PKs of ARV, TB, and hormonal contraceptive drugs in pregnant women. The development of appropriate dosing regimens for the HIV-infected pregnant woman is critical to the health of both mother and fetus. Overdosing may lead to maternal adverse events and increased risk of fetal toxicity, while underdosing may lead to inadequate virologic control, increased risk of developing drug resistance mutations, and a higher rate of perinatal HIV transmission. This study will evaluate the PKs of ARVs used during pregnancy; evaluate TB drugs used during pregnancy, both in women who are HIV-positive and also taking ARVs and in women who are HIV-negative and not taking ARVs; and evaluate the PKs of hormonal contraceptive medications taken along with ARVs.. There will be five main groups of study arms: HIV-infected pregnant ...
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Background Meralgia paresthetica is a common but underrecognized condition that is manifested by pain, numbness, and tingling in the anterior and lateral parts of the thigh. Bernhardt first described symptoms corresponding to meralgia paresthetica in 1878.
Meralgia paresthetica is a condition characterized by tingling, numbness and burning pain in your outer thigh. The cause of meralgia paresthetica is compression of the nerve that supplies sensation to the skin surface of your thigh.
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Meralgia paresthetica, also referred to as Bernhardt-Roth syndrome, is a numbness, burning or tingling sensation felt in the outer thigh.
MERALGIA PARESTHETICA is caused by a trapped nerve in the groin causing pain classically on the side of the thigh, but also sometimes the front of the thigh.
Meralgia paresthetica is caused by a trapped nerve in the groin causing burning and discomfort classically on the side of the thigh but also sometimes in front.
TY - CHAP. T1 - Pharmacogenomics of amphetamine and related drugs. AU - Kazmierczak, Steven (Steve). PY - 2012/1/1. Y1 - 2012/1/1. N2 - Illicit psychostimulant drugs such as amphetamines and derivatives represent a highly addictive class of compounds. Included in this group are L-amphetamine, ephedrine, methamphetamine, methylphenidate and pemoline, the latter used previously to treat attention-deficit hyperactivity disorder and narcolepsy. An additional compound also frequently included in this group is cathinone which is the active ingredient found in the leaves of the Khat shrub (Catha edulis) found primarily in East Africa and southern Arabia. Cathinone is easily extracted from fresh leaves of the Khat shrub upon chewing or following brewing and produces effects that are similar to that of amphetamine.. AB - Illicit psychostimulant drugs such as amphetamines and derivatives represent a highly addictive class of compounds. Included in this group are L-amphetamine, ephedrine, methamphetamine, ...
Results: A total of 262 patients with MP, 262 normal controls, and 262 BMI-matched normal controls with mean age of 50 years were identified (51% men). The age- and sex-adjusted incidence of MP was 32.6 per 100,000 patient years, whereas the incidence of MP in people with DM was 247 per 100,000 patient years, 7 times the occurrence of MP in the general population. Of the patients with MP, 28% had DM vs 17% of BMI-matched controls and the majority of people with MP developed DM after the diagnosis of MP. Patients with MP are 2 times more likely to develop DM (odds ratio 2, 95% confidence interval 1.3-3.0, p = 0.0027). The mean BMI of patients with MP (30.1 kg/m2, obese class I) was significantly higher than that of age- and gender-matched controls (27.3 kg/m2, overweight). MP incidence increased 12.9 per 100,000 patient years in the hemidecade study period with an associated increase in both BMI (2.2 kg/m2) and average age (3 years).. ...
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Butler, K., Breen, C. (2016). ACT Drug Trends 2015: Findings from the Illicit Drug Reporting System (IDRS). Sydney, NSW: National Drug and Alcohol Research Centre, University of New South Wales. Retrieved from https://ndarc.med.unsw.edu.au/resource/act-drug-trends-2015-findings-illicit-drug-reporting-system-idrs. Butler, K., & Breen, C. (2016). ACT Trends in Ecstasy and Related Drug Markets 2015: Findings from the ecstasy and related drugs reporting system (EDRS). Sydney, NSW: National Drug and Alcohol Research Centre, University of New South Wales. Retrieved from https://ndarc.med.unsw.edu.au/resource/act-trends-ecstasy-and-related-drug-markets-2015-findings-ecstasy-and-related-drugs. Cogger, S., Aitken, B., Lloyd, B., & Dietze, P. (2016). Victorian Drug Trends 2015: Findings from the Illicit Drug Reporting System (IDRS). Sydney, NSW: National Drug and Alcohol Research Centre, University of New South Wales. Retrieved from ...
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Many types of stresses occur within cells that have the HD gene, and examining how simple organisms cope can help scientists define new targets for HD drugs. A new study examines yeast to determine which proteins can protect these cells from damage and death, uncovering a protective antioxidant and a related drug.. Mutant huntingtin: slowing down the machine. Our genes provide a blueprint for constructing proteins, the building materials that make up every living thing. Each protein has a unique role within the well-oiled machine that is a single functioning cell. When one gear gets sticky, it can slowly but surely bring the whole operation down.. The gene that causes Huntingtons disease provides faulty instructions for the assembly of a protein called huntingtin, resulting in a extra lengthy, flawed product. We dont have a precise understanding of huntingtins normal role, or exactly why the mutant form works so poorly, but its presence is ultimately toxic to brain cells. Like deterioration ...
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Henkel V, Seemüller F, Obermeier M, Adli M, Bauer M, Mundt C, Brieger P, Laux G, Bender W, Heuser I, Zeiler J, Gaebel W, Mayr A, Möller H and Riedel M (2009): Does early improvement triggered by antidepressants predict response/remission? Analysis of data from a naturalistic study on a large sample of inpatients with major depression. Journal of Affective Disorders. 115(3): 439-49. Spanish version (2010): ¿Predice la mejoría precoz inducida por los antidepresivos la respuesta/remisión? Análisis de los datos de un estudio naturalista en una muestra a gran escala de pacientes hospitalizados con depresión mayor. Psiquiatría Biológica. 17(2): 45-53 ...
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