Chief cell - Wikipedia
The gastric chief cell (also known as a zymogenic cell or peptic cell) is a cell in the stomach that releases pepsinogen and chymosin. Pepsinogen is activated into the digestive enzyme pepsin when it comes in contact with acid produced by gastric parietal cells. This type of cell also secretes gastric lipase enzymes, which help digest triglycerides into free fatty acids and di- and mono-glycerides. There is also evidence that the gastric chief cell secretes leptin in response to the presence of food in the stomach. Leptin has been found in the pepsinogen granules of chief cells. Gastric pit cells are replaced every 2-4 days. This high rate of turnover is a protective mechanism designed to protect the epithelial lining of the stomach from both the proteolytic action of pepsin and the acid produced by parietal cells. Gastric chief cells are much longer lived and are believed to differentiate from stem cells located higher in the gastric unit in the isthmus. These stem cells ...
Chief cell financial definition of chief cell
Definition of chief cell in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is chief cell? Meaning of chief cell as a finance term. What does chief cell mean in finance?
Ink4a/Arf-Dependent Loss of Parietal Cells Induced by Oxidative Stress Promotes CD44-Dependent Gastric Tumorigenesis | Cancer...
Gastrointestinal malignancies are strongly linked to chronic inflammation (25-29). Gastric tumorigenesis in K19-Wnt1/C2mE mice was also recently shown to be suppressed by knockout of either TNFα or its receptor TNFR1, suggesting that TNFα-dependent inflammation plays a key role in the development of gastric cancer (30). Furthermore, the development of SPEM in response to acute parietal cell loss is dependent on the recruitment of macrophages to the gastric epithelium (31). Together, these findings suggest that inflammation triggers the histopathologic alterations of gastric epithelium that leads to tumor development. We have now shown that the inflammation-associated ROS plays a key role in the parietal cell loss that is an early and critical step in the development of SPEM, and the subsequent formation of gastric tumors. The accumulation of ROS triggers the p38MAPK-p16INK4a/p19ARF signaling pathway selectively in parietal cells and the consequent induction of parietal cell loss. In fact, ...
The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin | BMC Gastroenterology | Full Text
Appetite-reducing hormones, such as amylin, insulin, GIP, GLP-1, PP, and PYY, produced in the small intestine and pancreas are important in mammalian energy homeostasis, [32-35], as is leptin which is produced mostly by adipocytes, but also by gastric chief cells . Importantly, gastric oxyntic endocrine cells  account for 65-80% of the bodys total ghrelin production. H. pylori colonization status has been correlated with circulating and gastric mucosal leptin levels , and with gastric mRNA expression and plasma levels of ghrelin [9, 37]. We now identified substantial effects of H. pylori eradication on meal-associated changes in gastric hormones and energy balance, confirming and extending prior studies in a more rigorous manner [13, 38].. That H. pylori-positive and H. pylori-negative subjects had similar baseline digestive hormonal physiologies (Additional file 3, Table S4) may reflect the highly integrated cross-regulation of energy homeostasis,  and the long-term equilibria ...
What are the secretions of parietal and chief cells? | AnswersDrive
The two main types of exocrine secretory cells of the stomach are parietal cells and chief cells. Parietal cells secrete hydrochloric acid and chief cells secrete digestive enzymes such as pepsin.
The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage
In the mammalian gastrointestinal tract, the cell fate decisions that specify the development of multiple, diverse lineages are governed in large part by interactions of stem and early lineage progenitor cells with their microenvironment, or niche. Here, we show that the gastric parietal cell (PC) i …
Zymogenic cell definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now!
Histology MCQs GIT Questions And Answers | Physiology Plus
...Histology MCQs GIT (Questions and Answers)...Which cells secrete hydrochloric acid? a. Parietal cells b. Oxyntic cells c. Chief cells d. Mucous neck cells
Navy Hails Cosby as Honorary Chief Petty Officer - GlobalDefence.net -Streitkräfte der Welt
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cell death, or apoptosis (Kerr et al., 1972; One part of proliferated epithelia migrates Wyllie et al., 1980; Thompson, 1995; Raff, 1998). This article will focus on the role of which line the foveolae (pits) and the consideration of gastric histology, which epithelia migrate downwards in the gastric differs in the four anatomical subsites of glands. In the antrum, they differentiate the stomach. These four zones, i.e. cardia, within few days to mucous-secreting cells forming the pyloric glands. In the fundus for the TNM classification system) (UICC, and corpus, they differentiate within few 1997) are lined by two basically different weeks to chief cells, parietal cells, and suspected precursor cells can be identified mucosa is characterized by rather straight, Proliferation kinetics of the gastric antral cells, chief (or zymogenic) cells, parietal have concentrated on proliferation of the 1997). A second type of mucosa is present foveloar epithelium (Lipkin et al., 1963; in the distal third ...
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NHRA Chief Starter Mark Lyle Passes - Drag Illustrated | Drag Racing News, Opinion, Interviews, Photos, Videos and More
With great sadness, NHRA reported today that Mark Lyle, NHRAS Chief Starter, passed away unexpectedly this past Sunday. On behalf of NHRA and the entire drag racing community, we offer our condolences to all of Lyles family and friends.. Lyle had been Chief Starter for the NHRA Mello Yello Drag Racing Series since 2012. He was only the third Chief Starter in NHRA history, along with the late Buster Couch (1955-1996) and Rick Stewart (1996-2011). ...
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Xconomy: Ex-Nightstar Exec Ozden Joins Akouos as Chief Development Officer
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Vice Chiefs Detail Consequences of Budget Cuts - GlobalDefence.net -Streitkräfte der Welt
WASHINGTON, Oct. 27, 2011 - The vice chiefs of the ser-vices told Con-gress mem-bers today that they fear bud-get cuts could cause a hol-low force. The men said they under-stand that the ser-vices face a lean time, but they asked the House Armed Ser-vices Committees readi-ness sub-com-mit-tee to be judi-cious about cuts. Gen. Peter W. Chiarel-li, the Armys vice chief of staff, asked the rep-re-sen-ta-tives to remem-ber that the ser-vices have fought a 10-year war, with an all-vol-un-teer force. That force is amaz-ing-ly resilient, but at the same time, it is strained, he said. Its equip-ment is strained, sol-diers are strained, fam-i-lies are strained. But theyve been absolute-ly amaz-ing over these 10 years at war. Chiarel-li said he under-stands bud-get cuts and cor-re-spond-ing force reduc-tions have to be made. How-ev-er, we must make them respon-si-bly so that we do not end up with either a hol-lowed out force … or an unbal-anced force, he said. The Army con-tin-ues to look for ...
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Ron Klain of Chevy Chase will be President-elect Bidens chief of staff
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Seventh Judicial Administrative District Chief Judge Robert P. VanDeHey has been elected chairman of the Committee of Chief Judges.
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The Chief Ombudsman Peter Boshier has launched investigations into the Ministry of Healths oversight of facilities and services for intellectually disabled people with high and complex needs.
G20 financial chiefs agree open trade is key to growth-Schaeuble
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Invacare Announces Departure of Chief Financial Officer
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Industry Leader John Reynders Joins Moderna Therapeutics as Chief Information Officer | FierceBiotech
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The role and influence of the chief financial officer is undergoing a transformation, opening up new opportunities for finance...
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Press Ganey Names Christina Dempsey Chief Nursing Officer
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Chymosin - Wikipedia
Chymosin /ˈkaɪməsɪn/ or rennin /ˈrɛnɪn/ is a protease found in rennet. It is an aspartic endopeptidase belonging to MEROPS A1 family. It is produced by newborn ruminant animals in the lining of the abomasum to curdle the milk they ingest, allowing a longer residence in the bowels and better absorption. It is widely used in the production of cheese. Bovine chymosin is now produced recombinantly in E. coli, Aspergillus niger var awamori, and K. lactis as alternative resource. Chymosin is produced by ruminant animals in the lining of the abomasum. Chymosin is produced by gastric chief cells in young ruminants and some other newborn animals to curdle the milk they ingest, allowing a longer residence in the bowels and better absorption. Some other non-ruminant species, including pigs, cats, and seals, produce it. One study reported finding a chymosin-like enzyme in some human infants, but others have failed to replicate this finding. Humans have a pseudogene for chymosin that does not generate ...
EndoTODAY: 리뷰 더 리뷰 - metaplasia
참고문헌 1: Goldenring & Nam. Prog Mol Biol Transl Sci (2010) Review; Oxyntic atrophy, metaplasia, and gastric cancer - Gastric carcinogenesis involves the loss of parietal cells (oxyntic atrophy) and subsequent replacement of the normal gastric lineages with metaplastic cells. In humans, two metaplastic lineages develop as sequelae of chronic Helicobacter pylori infection: intestinal metaplasia and spasmolytic polypeptide-expressing metaplasia (SPEM). Mouse models of both chronic Helicobacter infection and acute pharmacological oxyntic atrophy have led to the discovery that SPEM arises from transdifferentiation of mature chief cells. The presence of inflammation promotes the expansion of SPEM in mice. Furthermore, studies in Mongolian gerbils as well as increasing evidence from human studies indicate that SPEM likely represents a precursor for the development of intestinal metaplasia. These findings suggest that loss of parietal cells, augmented by chronic inflammation, leads to a cascade ...
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Omeprazole preserves the RER in chief cells and enhances re‑epithelialization of parietal cells with SOD and AQP‑4 up...
The balance of protective and aggressive factors in the gastric mucosal barrier is an important consideration in gastrointestinal diseases (4). Gastric acid, pepsin, and external stimuli are known aggravating factors of gastric mucosal cells, while microcirculatory system, HCO3−, prostaglandins, epidermal growth factor synthesis, and epithelial cell reconstitution are gastro-protective factors that maintain integrity of the gastric mucosal layer. Obviously, there are several viewpoints in association with the effect of ethanol on gastric mucosal cells. However, the main pathogenesis of ethanol-induced gastritis is vascular damage followed by mucosal cell-hypoxia, -degeneration, and -necrosis, respectively. The decline of anti-oxidant level and over production of oxygen free radicals especially super-oxide and hydrogen peroxide, are also link to ethanol-induced gastric injury and play a crucial role to further induce gastric inflammatory response. In addition, ethanol itself destroys gastric ...
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But many, including Attawapiskat Chief Theresa Spence, who is on a liquids-only hunger strike, wanted a meeting with both Harper and Governor General David Johnston, and Atleo faced criticism, boycotts by chiefs from Manitoba and Ontario, and pressure from citizen protestors in the Idle No More movement.. In his statement, Atleo said First Nations citizens have just witnessed one of the most important chapters in our recent history.. Through the pressure of the grassroots, the sacrifices made by Chief Spence and her fellow strikers, and the work of many regional chiefs and the National Executive of the AFN, we have seized the attention of Canadians and of this government, he said. We forced open the door to the PMO and to the Governor-General. We achieved a commitment to the personal leadership of the Prime Minister, the Privy Council Office and other senior ministers. Now they know that the whole world is watching what progress we make. Now they understand the consequences of ...
AMD names chief financial officer - MarketWatch
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Army Chief General V K Singhs phenomenal record and leadership qualities could not prevent a number of controversies that marked his over two years stint as the Army Chief. Rediff.com takes a look. | FLASHBACK: The chequered stint of Army Chief Gen Singh
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Cells with conspicuous eosinophilic cytoplasm and centrally located nuclei (sometimes paired) are the parietal cells (P in the figure above).. Cells with basal nuclei, basally basophilic cytoplasm, and apical vesicles are the chief cells (C in the figure above).. The glands are separated by thinner strands of lamina propria, visible as strands of denser, flattened or irregular nuclei. ...
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Horizon Media announced that it has elevated its Chief Financial Officer, Vincent OToole, to Chief Operating Officer. OToole will also retain his Chief Financial Officer title. Before his time at Horizon Media, OToole was Senior Vice President and Controller at MTV Networks. He has also held senior-level positions at Simon & Schuster Publishing, Paramount Communications and Arthur Andersen.. Federated Wireless, Inc., a subsidiary of Allied Minds (LSE: ALM), announced the appointment of John Brunoas Chief Financial Officer and Senior Vice President. Before joining Federated Wireless, John worked at VidSys. Prior to VidSys, John served as Chief Financial Officer for Appfluent Technologies. He also previously held executive positions at Access Spectrum, LLC, Ericsson IP Infrastructure, and Torrent Networking Technologies, Inc.. M.D.C. Holdings, Inc. (NYSE: MDC) announced that the Companys current Chief Financial Officer, John M. Stephens, is resigning effective May 22, 2015. Mr. Stephens has ...
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MEC Names New North American Digital Chief - Adweek
Kaplowitz, who was named CEO of MEC N.A. eight months ago, said shes known Bamberger for more than 20 years, beginning when she was a DMB&B media planner on Procter & Gamble and he was a sales rep for Parade. Citing his expertise in integrated marketing, she said she was impressed with the path his career has taken since then. Hes taken some large interesting risks because of his curiosity, she said. He was very interested in social early on and figuring out where brands could fit in.. Before Dentsu, Bamberger was chief client officer at ad technology company, appssavvy. Prior to that job, he was executive vp of Katalyst, hired by co-founders Ashton Kutcher and Jason Goldberg. Earlier in his career, he worked on the publishing side when he worked at Meredith Corp. where his roles included the lead on Meredith 360 as chief innovation officer. Hes also held senior positions at Gruner & Jahr, USA and Time Warner Inc. where he worked with the companys The Parenting Group and Sports ...
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The Horse Came Back: Overwhelmed owners find a new home and an old owner for their horse Chief | Windsor Star
Chiefs history was murky. Chief was very old but fortunate that someone along the way had cared enough not to call the meat wagon or drop him at auction.
Police chiefs radical drugs call | Drugs-Forum
Police chiefs radical drugs call The Chief Constable of Tayside Police has called for a radical approach in tackling drug-related...
Chief RSMB040 Mini RPA Elite Projector Mount RSMB040 B&H Photo
Buy Chief RSMB040 Mini RPA Elite Projector Mount features Compact Design, Ideal for Smaller Projectors. Review Chief Projector Mounts, Projector Mounts & Accessories
Chief RSMB099 Mini RPA Elite Projector Mount RSMB099 B&H Photo
Buy Chief RSMB099 Mini RPA Elite Projector Mount features Compact Design, Ideal for Smaller Projectors. Review Chief Projector Mounts, Projector Mounts & Accessories
Bashaud Breeland vs Kenny Golladay: Chiefs Matchup - Full Press Coverage
Bashaud Breeland vs Kenny Golladay: Chiefs Matchup. For this weeks Chiefs and Lions game, we look at the Bashaud Breeland vs Kenny Golladay matchup.