Bachem offers H-4606 Interferon-Inducible T Cell α-Chemoattractant (human) for your research. Find all specific details here. Find product specific information including available pack sizes, CAS, detailed description and references here.

C-X-C motif chemokine 11 (CXCL11) is a protein that in humans is encoded by the CXCL11 gene.[3] C-X-C motif chemokine 11 is a small cytokine belonging to the CXC chemokine family that is also called Interferon-inducible T-cell alpha chemoattractant (I-TAC) and Interferon-gamma-inducible protein 9 (IP-9). It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate.[4] Gene expression of CXCL11 is strongly induced by IFN-γ and IFN-β, and weakly induced by IFN-α.[5] This chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10.[4][6] CXCL11 is chemotactic for activated T cells. Its gene is located on human chromosome 4 along with many other members of the CXC chemokine family.[7][8] ...

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Background Ulcerative colitis is characterized by relapsing mucosal inflammation where the lesions include tissue-damaging granulocytes. In addition, T cells and natural killer (NK) cells play important pathophysiologic roles. Chemokines are a large family of peptides that play key roles in the regulation of inflammation. The CXC-chemokines, growth-related oncogene (GRO)-α/CXCL1 and interleukin (IL)-8/CXCL8, both recruit neutrophils and possess mitogenic properties, whereas the interferon-dependent CXC-chemokines monokine induced by gamma-interferon (MIG)/CXCL9, interferon-γ inducible protein of 10 kD/CXCL10, and IFN-inducible T cell alpha chemoattractant/CXCL11 recruit and activate T cells and NK cells. Materials and methods The expression of CXC-chemokines was studied in eight controls and in 11 patients suffering from ulcerative colitis in the distal part of the colon, before and during topical treatment with corticosteroids. Perfusates (obtained before, after 7 days, and after 28 days of ...

Lemongrass ( Cymbopogon flexuosus ) essential oil (LEO), which has citral as its main component, has exhibited anti-inflammatory effect in both animal and human cells. In this study, we evaluated the anti-inflammatory activity of a commercially available LEO in pre-inflamed human dermal fibroblasts. We first studied the impact of LEO on 17 protein biomarkers that are critically associated with inflammation and tissue remodeling. LEO significantly inhibited production of the inflammatory biomarkers vascular cell adhesion molecule 1 (VCAM-1), interferon gamma-induced protein 10 (IP-10), interferon-inducible T-cell alpha chemoattractant (I-TAC), and monokine induced by gamma interferon (MIG); decreased levels of the tissue remodeling biomarkers collagen-I and III, epidermal growth factor receptor (EGFR), and plasminogen activator inhibitor (PAI-1); and inhibited the immunomodulatory biomarker macrophage colony-stimulating factor (M-CSF ...

TY - JOUR. T1 - Intrahepatic levels of CXCR3-associated chemokines correlate with liver inflammation and fibrosis in chronic hepatitis C. AU - Zeremski, Marija. AU - Petrovic, Lydia M.. AU - Chiriboga, Luis. AU - Brown, Queenie B.. AU - Yee, Herman T.. AU - Kinkhabwala, Milan. AU - Jacobson, Ira M.. AU - Dimova, Rositsa. AU - Markatou, Marianthi. AU - Talal, Andrew H.. PY - 2008/11/1. Y1 - 2008/11/1. N2 - Chemokines, chemotactic cytokines, may promote hepatic inflammation in chronic hepatitis C virus (HCV) infection through the recruitment of lymphocytes to the liver parenchyma. We evaluated the association between inflammation and fibrosis and CXCR3-associated chemokines, interferon-γ (IFN-γ)-inducible protein 10 (IP-10/CXCL10), monokine induced by IFN-γ(Mig/CXCL9), and interferon-inducible T cell α chemoattractant (I-TAC/CXCL11), in HCV infection. Intrahepatic mRNA expression of these chemokines was analyzed in 106 chronic HCV-infected patients by real-time PCR. The intrahepatic ...

|p|Recombinant Human I-TAC is a single non-glycosylated polypeptide chain containing 73 amino acids.|/p| |p|Background: I-TAC/CXCL11 cDNA encodes a 94 amino acid (aa) residue precursor protein with a 21 aa residue putative signal sequence, which is cleav

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Joachim Frank (Columbia University, New York, USA) is a pioneer of single particle reconstruction, which is the most used reconstruction method for 3DEM structures in EMDB and EM entries in PDB. And also, he is a develper of Spider, which is one of the most famous software in this field, and is used for some EM Navigor data (e.g. map projection/slice images ...

Human CXCL10 (IP-10) ELISA MAX™ Deluxe - CXCL10, also known as IP-10, is a glutamic acid-leucine-arginine motif negative chemokine structurally and functionally related to MIG (CXCL9) and ITAC (CXCL11).

Telus Corp.s use of Upopolis, a social networking tool designed specifically for hospitalized children, has earned the telecommunications giant a corporate IT hero award from the Information Technology Association of Canada (ITAC). Sponsored in part by IT World Canada, the annual ITAC IT Hero Awards celebrates one corporate and one community-based IT achievement that significantly […]

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This study provides extensive characterization of the novel high affinity SDF-1 (CXCL12)-binding receptor that we reported in an earlier publication (14). The novel receptor, initially designated CCX CKR2 (14) but renamed CXCR7 in this paper, is a 7-transmembrane receptor encoded by RDC1 (21, 22), a gene that, before our initial report (14), belonged to the family of orphan receptors with unknown ligands (20). In addition to binding SDF-1, CXCR7 is also a high affinity receptor for I-TAC (CXCL11) that, before our investigations, was regarded as a ligand for CXCR3 only. Our data show that CXCR7 regulates several important biological processes including cell survival, cell adhesion, and tumor development in animal models. CXCR7 is expressed on many tumor cells but not on most nontransformed cells. Although not expressed on unstimulated endothelial cells, CXCR7 can be induced, in vitro, on cells that form the neovasculature, a finding that is consistent with the independent studies of Madden et ...

Weighed against tumor cells, the LP EpCAM+ cells indicated very high degrees of the chemokines CXCL3 and CXCL5, as well as the BAL fluid included raised CXCL1, CXCL2, CXCL5, and CXCL7. have already been utilized and described to build up approaches for targeted treatments, the genomic surroundings of lung SCC is emerging now. There arent yet any authorized targeted therapies for lung SCC. Sadly, therapeutic focuses on in lung ADC, such as for example and (also called serine-threonine kinase 11 [mutations have become rarely within human being squamous lung tumors. Lately, it had been reported that kinase-dead was within reduction is probable a significant determinant of lung squamous tumorigenesis. Despite signs that reduction may be central towards the era of squamous cell malignancies, deletion of only struggles to travel tumor development (Ji et al., 2007). (phosphatase and tensin homolog) can be another frequently mutated, erased, or epigenetically silenced tumor suppressor in human being ...

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Les chimiokines sont des petites protéines secrétées dont la fonction principale est la stimulation de la migration de cellules immunitaires vers différents organes et tissus. Elles sont souvent impliquées lors des maladies inflammatoires, auto-immunes et des cancers. Ainsi, les chimiokines et leurs récepteurs couplés aux protéines G (RCPG) sont la cible pharmacologique de plusieurs molécules, actuellement testées en essais cliniques. Nous avons pris comme modèle, lors de notre étude, le récepteur atypique CXCR7. Ce récepteur est dit atypique, car il ne signalise pas via la voie classique des protéines G, mais plutôt via la voie de la β-arrestine. CXCR7 est impliqué dans de nombreux cancers, favorise la progression métastatique et est un co-récepteur pour le virus de limmunodéficience humaine (VIH). Cependant, aucune donnée sur son mode de liaison avec ses ligands CXCL11/ITAC et CXCL12/SDF-1 nexiste à date. Nous pensons que cette information est essentielle pour le ...

Human C-X-C Motif Chemokine 9 / Monokine Induced by Gamma Interferon (CXCL9 / MIG) standard, for use in running standard curves in AlphaLISA no-wash detection assay

IP-10 has been detected in the CSF and brain parenchyma of patients with a variety of neuroinflammatory diseases (15, 26, 43, 44) and is a potent chemoattractant for activated T lymphocytes and NK cells (11). In EAE, an animal model for MS, IP-10 levels in the CNS have been correlated with the development of clinical disease and the recruitment of CXCR3-expressing pathogenic T cells (19, 20, 45). Treatment of SJL mice with Abs to IP-10 before adoptive transfer of encephalitogenic T cells or immunizing mice with naked IP-10 DNA decreased the severity of EAE (29). Based on these observations, IP-10 is thought to be essential for the development of CNS mononuclear infiltrates, and its receptor CXCR3, is considered a putative therapeutic target for diseases involving the trafficking of inflammatory T cells. However, the absolute requirement for IP-10 in EAE has never been directly examined.. In this study, we sought to determine whether IP-10 is required for the development of EAE by analyzing ...

Purified Recombinant Human CXCR2 HEK293T cell lysate from Creative Biomart. Recombinant Human CXCR2 HEK293T cell lysate can be used for research.

LEGEND MAX™ Human CXCL10 (IP-10) ELISA Kit with Pre-coated Plates - CXCL10, also known as IP-10, is a glutamic acid-leucine-arginine motif negative chemokine structurally and functionally related to MIG (CXCL9) and ITAC (CXCL11).

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MIG (CXCL9) Bovine Recombinant is a non-glycosylated polypeptide chain containing 104 amino acids and having a molecular mass of about 18.0kDa.

Recombinant Human MIG/CXCL9 produced in E. coli is a single, non-glycosylated polypeptide chain containing 103 amino acids and having a molecular mass of 11.7 kDa.

Aortic and plasma expression levels of IL-18 and CXCL16.(A) Reduced aortic mRNA expression of IL-18 and CXCL16, but no change in the expression of IFN-γ is obs

Chemokines mediate diverse fundamental biological processes, including combating infection. Multiple chemokines are expressed at the site of infection; thus chemokine synergy by heterodimer formation may play a role in determining function. Chemokine function involves interactions with G-protein-coupled receptors and sulfated glycosaminoglycans (GAG). However, very little is known regarding heterodimer structural features and receptor and GAG interactions. Solution nuclear magnetic resonance (NMR) and molecular dynamics characterization of platelet-derived chemokine CXCL7 heterodimerization with chemokines CXCL1, CXCL4, and CXCL8 indicated that packing interactions promote CXCL7-CXCL1 and CXCL7-CXCL4 heterodimers, and electrostatic repulsive interactions disfavor the CXCL7-CXCL8 heterodimer. As characterizing the native heterodimer is challenging due to interference from monomers and homodimers, we engineered a

Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells. J Immunol. 2000 Jun 15; 164(12):6503-8 ...

This study examined the association of interferon-gamma-inducible protein-10 concentrations in serum and IL28B genotype associated with responses to pegylated

CXCL12 izaziva potentnu hemotaksu limfocita.[4][5][6][7] Tokom embriogeneze on usmerava migraciju hematopoetskih ćelija i formiranje velikih krvnih sudova. Miševi bez CXCL12 gena su letalni pre rođenja, ili u toku prvog sata života. Kod odraslih CXCL12 igra važnu ulogu u angiogenezi putem regrutovanja endotelnih progenitorskih ćelija (EPC) iz koštane srži kroz CXCR4 zavistan mehanizam.[8] Ova funkcija čini CXCL12 veoma važnim faktorom u karcinogenezi i neovaskularizaciji vezanoj za progresiju tumora.[9] CXCL12 takođe ima ulogu u metastazi tumora gde su ćelije raka koje izražavaju CXCR4 receptor privučene ka metastaznim ciljnim tkivima koja oslobađaju ligand, CXCL12.[10] Kod raka dojke, međutim, povećano CXCL12 izražavanje određuje umanjeni rizik od metastaze.[11][12] ...

For all those datasets cell doublets were excluded (i.e., cells which were designated to confirmed cell alpha or typebeta cell, yet express an assortment of cell type-specific markerssuch as both Glucagon and Insulin) (Fig S1, S2, S11). cells, two sub-populations of cells had been determined which diverged in mtDNA gene manifestation, however these mobile populations didnt diverge in nDNA OXPHOS genes manifestation regularly, nor do they correlate using the manifestation of glucagon, the sign of alpha cells. Therefore, pancreatic beta cells in a specific are split into specific groups with original metabolic-mitochondrial personal. with parameter (BWA-backtrack algorithm)57; this allowed following analysis for many mtDNA encoded-genes. Manifestation degrees of all genes had been counted using HTSeq-count v0.11.258, using default guidelines and employing the [-f bam] guidelines. For quality control filtering, gene count number values as described by HTSeq-count had been concatenated right into a ...

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affin

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affin

References for Abcams Recombinant human CXCL5 protein (ab50039). Please let us know if you have used this product in your publication

The ESAB Aristo Mig 5000i is the ideal partner for when it comes to prefabrication of high alloyed materials with a high demand for the welding performance.

p53 protein levels increase in HDFs, such as IMR90 and MRC5, during replicative senescence (8-11). Moreover, p53 sequence-specific DNA-binding activity and transcriptional activity also increase during replicative senescence (9, 12). These studies (8-12) have suggested a role for p53 in the onset and maintenance of cellular senescence. Consistent with this idea, the p53-mediated induction of p21 and Gadd45 genes in normal human cells is known (13, 16, 17) to play a role in cell growth arrest. However, the number of p53 target genes whose expression is induced during cellular senescence in HDFs remains rather limited. Therefore, our observations that p53 activates the transcription of IFI16, a candidate cellular senescence gene, in response to certain DNA damage signals in normal human fibroblasts are important.. The IFI16 protein is an IFN-inducible protein and treatment of a variety of cells with IFNs (α, β, or γ) has been shown to result in up-regulation of the IFI16 mRNA and protein (21). ...

GPR-9-6 is a chemokine receptor for TECK. (A) GPR-9-6 transfectants were examined for chemotactic responses to various concentrations of TECK and I-TAC ranging

CXCL16 is a member of the CXC chemokine family and signals through the CXCR6 receptor. CXCL16 may play a role in attracting lymphocyte subsets

人生长调节致癌基因γ(GRO-γ/CXCL3) (Human)首选赛业生物，380余种细胞因子囊括生长调节致癌基因、生长因子、干扰素、白细胞介素、肿瘤坏死因子等所有细胞因子家族，种属齐包括人、鼠、恒河猴及其他种属。赛业提供的生长调节致癌基因品质优良：高活性、高纯度、高稳定性、无热源、无外源因子污染。

Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family that is also known as Monokine induced by gamma interferon (MIG). CXCL9 is a T-cell chemoattractant, which is induced by IFN-γ. It is closely related to two other CXC chemokines called CXCL10 and CXCL11, whose genes are located near the gene for CXCL9 on human chromosome 4. CXCL9, CXCL10 and CXCL11 all elicit their chemotactic functions by interacting with the chemokine receptor CXCR3. Neutrophil collagenase/matrix metalloproteinase 8 (MMP-8) degrades CXCL9 and cleaves CXCL10 at two positions. Gelatinase B/matrix metalloproteinase 9 (MMP-9) degrades CXCL10 and cleaves CXCL9 at three different sites in its extended carboxy-terminal region ...

Recent work identified the murine gene homologous to the human T cell attracting chemokine CXC receptor ligand 11 (CXCL11, also termed I-TAC, SCYB11, ss-R1, H174, IP-9). Here, the biological activity and expression patterns of murine CXCL11 relative to CXCL9 (MIG) and CXCL10 (IP-10/crg-2), the other …

CXCL16, hemokin (C-X-C motiv) ligand 16, je mali citokin iz CXC hemokin familije. On je veći od drugih hemokina (sadrži 254 aminokiselina). CXCL16 se sastoji od CXC hemokin domaina, mucinu-slične stabljike, transmembranskog domaina i citoplazmatičnog repa koji sadrži potentno mesto tirozin fosforilacije koje može da veže SH2.[1] Ovo su neuobičajene osobine za hemokin, i omobućavaju CXCL16 da bude izražen kao molekul na ćelijskoj površini, kao i rastvorni hemokin.[2] CXCL16 proizvode dendritiske ćelije koje se mogu naći u T ćelijskim zonama limfoidnih organa, i ćelije iz crvene pulpe slezine.[1] Među ćelijama koje se vezuju i migriraju u responsu na CXCL16 su nekoliko podgrupa T ćelija, i NKT ćelije.[1] CXCL16 interaguje sa hemokin receptorom CXCR6, takođe poznatim kao Bonzo.[3][1] Ekspresiju CXCL16 indukuju inflamatorni citokini IFN-gama i TNF-alfa.[2] Gen za ljudski CXCL16 je lociran na hromozomu 17.[1][4] ...

CXCL12 izaziva potentnu hemotaksu limfocita.[4][5][6][7] Tokom embriogeneze on usmerava migraciju hematopoetskih ćelija i formiranje velikih krvnih sudova. Miševi bez CXCL12 gena su letalni pre rođenja, ili u toku prvog sata života. Kod odraslih CXCL12 igra važnu ulogu u angiogenezi putem regrutovanja endotelnih progenitorskih ćelija (EPC) iz koštane srži kroz CXCR4 zavistan mehanizam.[8] Ova funkcija čini CXCL12 veoma važnim faktorom u karcinogenezi i neovaskularizaciji vezanoj za progresiju tumora.[9] CXCL12 takođe ima ulogu u metastazi tumora gde su ćelije raka koje izražavaju CXCR4 receptor privučene ka metastaznim ciljnim tkivima koja oslobađaju ligand, CXCL12.[10] Kod raka dojke, međutim, povećano CXCL12 izražavanje određuje umanjeni rizik od metastaze.[11][12] ...

Thursday, July 20, 1950 ER War Could Hurt Arkansas Balance of Agri-Industry Note: Thi. k itac I»s( X * Kritc of ftorta discussing Arkansu economic, induclrul and business raini) BT RAKI.KV PCKSHING KOCK, July 20. (AP) - Where would Arkansa. Edition of The Courier News

The anaerobic bacterium Finegoldia magna is part of the human commensal microbiota, but is also an important opportunistic pathogen. This bacterium expresses a subtilisin-like serine proteinase, SufA, which partially degrade the antibacterial chemokine MIG/CXCL9. Here, we show that MIG/CXCL9 is produced by human keratinocytes in response to inflammatory stimuli. In contrast to the virulent human pathogen Streptococcus pyogenes, the presence of F. magna had no enhancing effect on the MIG/CXCL9 expression by keratinocytes, suggesting poor detection of the latter by pathogen-recognition receptors. When MIG/CXCL9 was exposed to SufA-expressing F. magna, the molecule was processed into several smaller fragments. Analysis by mass spectrometry showed that SufA cleaves MIG/CXCL9 at several sites in the COOH-terminal region of the molecule. At equimolar concentrations, SufA-generated MIG/CXCL9 fragments were not bactericidal against F. magna, but retained their ability to kill S. pyogenes. Moreover, the ...

CXCL10, hemokin (C-X-C motiv) ligand 10, ili IP-10[1] je mali citokin iz CXC hemokin familije koji je takođe poznat kao 10 kDa interferon-gama-inducirani protein (γ-IP10 ili IP-10). CXCL10 luči nekoliko ćelijski tipova u responsu na IFN-γ. U te ćelijske tipove spadaju monociti, endotelijalne ćelije i fibroblasti.[2] CXCL10 hemokinu je bilo pripisano nekoliko uloga, kao što su hemoatrakcija monocita/makrofaga, T ćelija, NK ćelija, i dendritskih ćelija, promocija adhezije T ćelija na endotelijalne ćelije, antitumorska aktivnost, i inhibicija formiranja kolonija kičmene moždine i angiogeneze.[3][4] CXCL10 gen je lociran na ljudskom hromozomu 4 u klasteru sa nekoliko drugih CXC hemokina.[5] Ovaj hemokin dejstvuje putem vezivanja na CXCR3 hemokin receptore na ćelijskoj površini.[6]. Tri-dimenzionalna kristalna struktura ovog hemokina je bila utvrđena u 3 različite grupe uslova u rezoluciji do 1.92 A.[7] PDB pristupni kodovi za CXCL10 strukture su: 1lv9, 1o7y, 1o7z i 1o80.[8] ...

Waterproofing is the process by which an object is made to resist the ingress of water and is a common requirement in construction coatings and fabric coatings. In construction, waterproofing is required to maintain the building envelope. In addition to this, waterproofing is an integral part of controlling corrosion which requires both water and oxygen to progress. In fabric coating, waterproofing is measured by the head of water (in mm) which can be suspended above the fabric before water seeps through with typical fabric coatings achieving 2,000mm to 3,000mm before allowing water to pass through. This test is more commonly known as the Hydrostatic head test. Fabric coatings can also be used to reduce the rate of absorption of water into the fabric. Waterproofing is particularly important in products such as rainwear, tarpaulins, pond liners, landfill liners, marquees, and tents ...

Cxcl12 - Cxcl12 (untagged ORF) - Rat chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) (Cxcl12), transcript variant 3, (10 ug) available for purchase from OriGene - Your Gene Company.

Interferon gamma-induced protein 10 (IP-10), or CXCL10, is a chemokine secreted by monocytes, endothelial cells and fibroblasts in response to interferon gamma (IFN-ɣ).

IP-10 (CXCL10) regulates innate and adaptive immunity by regulating T cells, natural killer cells, dendritic cells, macrophages, and B cells.

Rutar, M, Natoli, R, Chia, R et al 2015, Chemokine-mediated inflammation in the degenerating retina is coordinated by Müller cells, activated microglia, and retinal pigment epithelium, Journal of Neuroinflammation, vol. 12, no. 8, pp. 1-15. ...

The IUPHAR/BPS Guide to Pharmacology. CXCL8 ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.

The IUPHAR/BPS Guide to Pharmacology. CXCL2 ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.