Several studies have shown the beneficial effects of polyunsaturated fatty acids on inflammatory processes, dyslipidemia, and cardiovascular diseases, there are no reports about food intake and PUFA supplementation in chronic Chagas cardiomyopathy patients. Thus, the objective of this study is to assess the effects of omega-3 PUFA supplementation on the lipid profile and the pro-inflammatory and anti-inflammatory cytokine profiles in chronic Chagas cardiomyopathy patients.. After patients are selected by cardiologists, they will be seen by study nutritionists, who will explain the study procedures to the patients and administer the free and informed consent form. The patients who agree to participate in the study will sign the consent form and undergo the initial assessment.. The following data will be collected and evaluated in the study: sociodemographic data (age, sex, ethnicity/race, education, and domicile), clinical data (functional class and vital signs), alcoholism, smoking, prescription ...

Background: Polymerase chain reaction (PCR) allows detection of Trypanosoma cruzi in blood throughout the course of Chagas disease.. Objective: To determine whether T cruzi DNA detected by PCR is associated with progression to chronic Chagas cardiomyopathy.. Design: Prospective cohort study.. Setting: A tertiary care centre in Argentina.. Patients: 56 consecutive patients with chronic T cruzi infection.. Methods: Clinical examination, ECG, and Doppler echocardiography were carried out at baseline and at the end of the follow up. Detection of T cruzi DNA by PCR amplifying a nuclear sequence was undertaken in all patients at baseline.. Main outcome measures: Progression was defined as death from chronic cardiomyopathy or the presence of a new ECG or left ventricular echocardiographic abnormality at the end of follow up.. Results: The 56 patients (21 male, 35 female; mean (SD) age, 56.0 (11.3) years) were followed for a mean 936.3 (244.39) days. Progression to cardiomyopathy was detected in 12 ...

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, affects 7 million people in Latin American areas of endemicity. About 30% of infected patients will develop chronic Chagas cardiomyopathy (CCC), an inflammatory cardiomyopathy characterized by hypertrophy, fibrosis, and myocarditis. Further studies are necessary to understand the molecular mechanisms of disease progression. Transcriptome analysis has been increasingly used to identify molecular changes associated with disease outcomes. We thus assessed the whole-blood transcriptome of patients with Chagas disease. Microarray analysis was performed on blood samples from 150 subjects, of whom 30 were uninfected control patients and 120 had Chagas disease (1 group had asymptomatic disease, and 2 groups had CCC with either a preserved or reduced left ventricular ejection fraction [LVEF]). Each Chagas disease group displayed distinct gene expression and functional pathway profiles. The most different expression patterns were between ...

Abstract. Approximately 8 million people have Trypanosoma cruzi infection, and nearly 30% will manifest Chagas cardiomyopathy (CC). Identification of reliable early indicators of CC risk would enable prioritization of treatment to those with the highest probability of future disease. Serum markers and electrocardiogram (EKG) changes were measured in 68 T. cruzi-infected individuals in various stages of cardiac disease and 17 individuals without T. cruzi infection or cardiac disease. T. cruzi-infected individuals were assigned to stage A (normal EKG/chest x-ray [CXR]), B (abnormal EKG/normal CXR), or C (abnormal EKG/cardiac structural changes). Ten serum markers were measured using enzyme-linked immunosorbent assay (ELISA)/Luminex, and QRS scores were calculated. Higher concentrations of transforming growth factor-β1 (TGFβ1), and TGFβ2 were associated with stage B compared with stage A. Matrix Metalloproteinase 2 (MMP2), Tissue Inhibitors of MMP 1, QRS score, and Brain Natriuretic Protein rose

Diagnostic Tests for Chagas Cardiomyopathy including blood tests, urine tests, swabs, diagnostic tests, lab tests, and pathology testing.

TY - JOUR. T1 - Brain natriuretic peptide and left ventricular dysfunction in chagasic cardiomyopathy. AU - Talvani, Andre. AU - Rocha, Manoel O C. AU - Cogan, John. AU - Maewal, Param. AU - de Lemos, James A. AU - Ribeiro, Antonio L P. AU - Teixeira, Mauro M.. PY - 2004/10. Y1 - 2004/10. N2 - Global left ventricular (LV) systolic dysfunction is the strongest predictor of morbidity and mortality in Chagas disease. Echocardiography is considered the gold standard for the detection of LV dysfunction, but not always available in endemic areas where chagasic cardiomyopathy is most common. Brain natriuretic peptide (BNP) is a neurohormone that has been recently described as a simple and inexpensive diagnostic and prognostic marker for patients with congestive heart failure. Chagasic patients (n = 63) and non-infected healthy individuals (n = 18) were recruited prospectively and underwent complete clinical examination, echocardiography and 24-h Holter monitoring. BNP was measured from thawed plasma ...

Chronic chagasic cardiomyopathy, which is caused by the protozoan Trypanosoma cruzi, is a major cause of heart failure in Latin America. It is a disease for which effective treatment in its advanced clinical forms is lacking. We have previously shown that bone marrow mononuclear cell (BMC) transplantation is effective in reducing inflammation and fibrosis in the mouse model of Chagas disease. The present study used magnetic resonance un-aging to assess changes in the cardiac morphology of infected mice after therapy with BMCs. Serial imaging of the BMC-treated mice revealed regression of the right ventricular dilatation typically observed in the chagasic mouse model ...

Chronic chagasic cardiomyopathy (CCC) develops years after acute infection by Trypanosoma cruzi and does not improve after trypanocidal therapy, despite reduction of parasite burden. During disease, the heart undergoes oxidative stress, a potential causative factor for arrhythmias and contractile dysfunction. Here we tested whether antioxidants/ cardioprotective drugs could improve cardiac function in established Chagas heart disease. We chose a model that resembles B1-B2 stage of human CCC, treated mice with resveratrol and performed electrocardiography and echocardiography studies. Resveratrol reduced the prolonged PR and QTc intervals, increased heart rates and reversed sinus arrhythmia, atrial and atrioventricular conduction disorders; restored a normal left ventricular ejection fraction, improved stroke volume and cardiac output. Resveratrol activated the AMPK-pathway and reduced both ROS production and heart parasite burden, without interfering with vascularization or myocarditis ...

Several induced cardiomyopathy , Mycoplasma pneumonia-induced myocarditis, heart damage investigations have shown positive effects of Se on experimental models: cardiotoxicity induced by chemotherapics, ischemic cardiopathy, CVB3 and LP-BM5 (murine AIDS, retrovirus)-in reperfused heart, and in chagasic cardiopathy. In addition, beneficial effects of Se supplementation were reported in patients with myocardial infarct, Keshan disease, and cardiac dysfunction during HPN.. Our group has investigated the role and Se effect on infection by T. cruzi. By evaluating plasma Se levels in 170 chagasic patients, we discovered that the frequency of subjects with Se levels lower than normal was significantly higher in those with severe cardiopathy. Moreover, in this pioneering research, we found a positive correlation between Se levels and the LVEF, indicating that normal Se levels pave the way for efficient cardiac function. Later, we investigated if nutritional deficiency of this trace element interfered ...

Chagas disease remains a significant public health issue in many countries and is a major cause of morbidity and mortality in Latin America. The social impact of this disease can be evaluated by the estimated human infection prevalence of 16 million people (1) in this region. Chronic Chagas heart disease is certainly the most important clinical form of Chagas disease. Chronic cardiac involvement is more prevalent and is also associated with grater morbidity and mortality when compared to the digestive form (2,3). In the natural history of the disease, the progression of cardiac involvement is heterogeneous and tends to be slow: about 70% of cardiac patients who have mild cardiac involvement, without heart failure, remain clinically stable for periods ranging from 12 to 27 years of follow-up (4). The majority of patients with Chagas disease remain in the indeterminate form of the disease for 10-30 years or even more. They have positive serology, no symptoms or signs of Chagas disease, and ...

Background: Though the incidence of new Trypanosoma cruzi infections has decreased significantly in endemic regions in the Americas, medical professionals continue to encounter a high burden of resulting Chagas disease among infected adults. The current prevalence of Chagas heart disease in a community setting is not known; nor is it known how recent insecticide vector control measures may have impacted the progression of cardiac disease in an infected population.. Objectives: We sought to determine the current prevalence of T. cruzi infection and associated Chagas heart disease in a Bolivian community endemic for T. cruzi.. Methods: Nested within a community serosurvey in rural and periurban communities in central Bolivia, we performed a cross-sectional cardiac substudy to evaluate adults for historical, clinical, and electrocardiographic evidence of cardiac disease. All adults between the ages of 20 and 60 years old with T. cruzi infection and those with a clinical history, physical exam, or ...

Pathology and Pathogenesis of Chagas Heart Disease. Annu Rev Pathol. 2018 Oct 24;: Authors: Bonney KM, Luthringer DJ, Kim SA, Garg NJ, Engman DM Abstract Chagas heart disease is an inflammatory cardiomyopathy that develops in approximately one-third of people infected with the protozoan parasite Trypanosoma cruzi. One way T. cruzi is transmitted to people is through contact w...

REFERENCES. 1. Traina MI, Hernandez S, Sanchez DR, Dufani J, Salih M, Abuhamidah AM, et al. Prevalence of Chagas Disease in a U.S. Population of Latin American Immigrants with Conduction Abnormalities on Electrocardiogram. PLoS Negl Trop Dis. 2017;11(1):e0005244. DOI: 10.1371/journal.pntd.0005244. [ Links ]. 2. World Health Organization. Chagas disease in Latin America: an epidemiological update based on 2010 estimates. Wkly Epidemiol Rec. 2015;90(6):33-43. PMID: 25671846 [ Links ]. 3. Pérez-Molina JA, Molina I. Chagas disease. Lancet. 2018;391(10115):82-94. DOI: 10.1016/S0140-6736(17)31612-4. [ Links ]. 4. Rocha MO, Ribeiro AL, Teixeira MM. Clinical management of chronic Chagas cardiomyopathy. Front Biosci. 2003;8:e44-54. PMID: 12456332. [ Links ]. 5. Rassi A Jr, Rassi SG, Rassi A. Sudden death in Chagas disease. Arq Bras Cardiol. 2001;76 (1):75-96. PMID: 11175486. [ Links ]. 6. Bern C, Montgomery SP, Herwaldt BL, Rassi A Jr, Marin-Neto JA, Dantas RO, et al. Evaluation and treatment of Chagas ...

Unfortunately, one century after its discovery (Chagas 1909), Chagas disease still affects millions of poor people in several Latin American countries...

Author Summary Trypanosoma cruzi is a protozoan parasite responsible for Chagas disease. Chronic Chagas heart disease (cChHD) is not only the most frequent and severe consequence of the chronic infection by T. cruzi, but is also the main cause of cardiomyopathy in South and Central America. Patients with cChHD possess high levels of antibodies against the carboxyl-terminal tail of the ribosomal P proteins of T. cruzi (called the R13 epitope). These antibodies, as well as the murine monoclonal antibody (mAb) 17.2, are able to cross-react with, and stimulate, the ß1 adrenergic receptor (ß1-AR). Indeed, the mAb 17.2 was able to specifically detect human β1-AR and induce some of the classical cardiac symptoms after passive transfer to mice. To study the structural basis of this cross-reactivity, we determined the crystal structure of the Fab region of the mAb 17.2 alone and in complex with R13. Additionally, we generated a model of human β1-AR to elucidate the interaction with anti-R13 antibodies in

In a rodent model of chronic ChHD, the administration of carvedilol did not change ventricular remodeling and function or interstitial and perivascular fibrosis; additionally, total mortality was unchanged, even though early mortality (up to 100 days with infection) was reduced with carvedilol (62). However, carvedilol was effective in attenuating oxidative damage in ChHD patients after 6 months of treatment in a prospective, case-control, nonrandomized, open-label study (63). Also, a study with 9 patients with ChHD-HF tested the effects of metoprolol (titrated up to 25 mg) and found improvement in functional status, increase in LVEF, and reduction in LV end-diastolic diameter (64). Retrospective analyses have suggested a beneficial effect of β-blockers in patients with ChHD-HF. In a cohort of 231 consecutive patients with ChHD-HF, β-blocker therapy had a protective effect (65). A retrospective analysis of the REMADHE trial (A Long-Term Prospective Randomized Controlled Study Using Repetitive ...

TY - JOUR. T1 - Increased oxidative stress contributes to cardiomyocyte dysfunction and death in patients with Fabry disease cardiomyopathy. AU - Chimenti, Cristina. AU - Scopelliti, Fernanda. AU - Vulpis, Elisabetta. AU - Tafani, Marco. AU - Villanova, Lidia. AU - Verardo, Romina. AU - De Paulis, Ruggero. AU - Russo, Matteo A.. AU - Frustaci, Andrea. PY - 2015/11/1. Y1 - 2015/11/1. N2 - Cardiac dysfunction of Fabry disease (FD) has been associated with myofilament damage and cell death as result of α-galactosidase A deficiency and globotriaosylceramide accumulation. We sought to evaluate the role of oxidative stress in FD cardiomyocyte dysfunction. Myocardial tissue from 18 patients with FD was investigated for the expression of inducible nitric oxide synthase (iNOS) and nitrotyrosine by immunohistochemistry. Western blot analysis for nitrotyrosine was also performed. Oxidative damage to DNA was investigated by immunostaining for 8-hydroxydeoxyguanosine (8-OHdG), whereas apoptosis was ...

Figure 6: Inferoseptal thinning (left panel) of the left ventricular myocardium and LGE (right panel) in the inferior, inferoseptal, and anteroseptal segments (arrows). Perspective:. LGE is correlated with inducible ventricular tachycardia and sudden death in many myocardial diseases, such as ischemic, hypertrophic, dilated, or arrhythmogenic right ventricular cardiomyopathy as well as in chronic Chagas heart disease [2]. The presence and the extent of LGE is also associated with recurrent tachyarrhythmia and even sudden cardiac arrest [3]. New onset left bundle branch block has been described in patients with myocarditis [4].. We report a case of acute lymphocytic myocarditis with a pattern of LGE correlating with conduction disturbances such as total AV Block, and with ventricular arrhythmia. This case illustrates the ability of CMR to demonstrate the acute changes occurring during myocarditis and by using LGE to show the substrate of electrophysiological disturbances caused by myocardial ...

Figure 6: Inferoseptal thinning (left panel) and LGE (right panel) of the left ventricular myocardium (arrows). Perspective:. LGE is correlated with inducible ventricular tachycardia and sudden death in many myocardial diseases, such as ischemic, hypertrophic, dilated, or arrhythmogenic right ventricular cardiomyopathy as well as in chronic Chagas heart disease (Mavrogeni 2013). The presence and the extent of LGE is also associated with recurrent tachyarrhythmia and even sudden cardiac arrest (Neilan 2015). New onset left bundle branch block has been described in patients with myocarditis (Mavrogeni 2014).. We report a case of acute lymphocytic myocarditis with a pattern of LGE correlating with conduction disturbances such as total AV Block, and with ventricular arrhythmia. This case illustrates the occurrence of right bundle branch block, left anterior hemi-block, and even transient complete atrioventricular block in myocardial inflammation and its visibility by CMR.. This case proves that CMR ...

Background. Only a subset of individuals infected with Trypanosoma cruzi develop chronic Chagas cardiomyopathy (CCC). Familial aggregation of CCC in areas of endemicity indicates that susceptibility may be genetic, which may be a plausible explanation for why only one-third of T. cruzi-infected individuals develop CCC. The monocyte chemoattractant protein-1 (CCL2/MCP-1) has been shown to enhance the uptake of T. cruzi in murine macrophages and to up-regulate the inducible nitric oxide synthase/nitic oxide system, with a consequent increased production of nitric oxide that controls the replication of the parasite.. Methods. We assessed CCL2 variants at position -2518A/G, which are known to influence transcriptional activity, by polymerase chain reaction and restriction fragment-length polymorphism in 245 individuals, all of whom were infected with T. cruzi. One hundred sixty-nine patients had CCC, and 76 were asymptomatic.. Results. Genotype distributions differed between the CCC and asymptomatic ...

heart disease of unknown etiology, or told you cant give blood cuz Chagas? call us ipsum doloret no this is not realy latin semper ubi sub ubi yes it...

González-Herrera F. et al. (2016). Simvastatin attenuates endothelial activation through 15-epi-lipoxin A4 production in murine chronic Chagas cardiomyopathy. Antimicrob Agents Chemother. Dec 19. pii: AAC.02137-16.. ​. Droguett, D., et al. (2016). Trypanosoma cruzi induces cellular proliferation in the trophoblastic cell line BeWo.Exp Parasitol. Dec 8;173:9-17. doi: 10.1016/j.exppara.2016.12.005.. ​. Ponce, I., et al. (2016). A Flap Endonuclease (TcFEN1) Is Involved in Trypanosoma cruzi Cell Proliferation, DNA Repair, and Parasite Survival. J Cell Biochem.Dec 9. doi: 10.1002/jcb.25830.. Ormeño, F. et al.,(2016). Expression and the Peculiar Enzymatic Behavior of the Trypanosoma cruzi NTH1 DNA Glycosylase.PLoS One. Jun 10;11(6):e0157270. doi: 10.1371/journal.pone.0157270. ​. Liempi, A., er al. (2016). A local innate immune response against Trypanosoma cruzi in the human placenta: The epithelial turnover of the trophoblast. Microb Pathog.Oct;99:123-129. doi: ...

A total of 130 patients were included; mean age was 53.6 ± 11.5 years, and 53.9% were female. The majority of patients reported no symptoms of heart failure or arrhythmia, but electrocardiographic and echocardiographic abnormalities were common. On CMR, left ventricular dilatation and dysfunction were frequent, and MF was found in 76.1%, with a mean mass of 15.2 ± 16.5 g. Over a median follow-up of 5.05 years, 58 (44.6%) patients reached the combined endpoint, and 45 (34.6%) patients died. MF was associated with the primary outcome as a continuous variable (adjusted hazard ratio: 1.031; 95% CI: 1.013 to 1.049; p = 0.001) and as a categorical variable (MF ≥12.3 g) (adjusted hazard ratio: 2.107; 95% CI: 1.111 to 3.994; p = 0.022), independently from the Rassi risk score. MF expressed as a continuous variable was also associated with all-cause mortality (adjusted hazard ratio: 1.028; 95% CI: 1.005 to 1.051; p = 0.017) independently from the Rassi risk score ...

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LEMOS DE OLIVEIRA, LUCIANO FONSECA... Regional Myocardial Perfusion Disturbance in Experimental Chronic Chagas Cardiomyopathy. JOURNAL OF NUCLEAR MEDICINE 59 n.9 p. 1430-1436 SEP 1 2018. Journal article.

Introduction: Scar in Chagas heart disease (CHD) is thought to be predominantly epicardial and requires epicardial access for ventricular tachycardia (VT) ablation. However, little data exists on scar patterns in this population. We evaluated the patterns of scar in patients who underwent magnetic resonance imaging (MRI) with delayed enhancement (DE).. Methods: 19 patients were enrolled who had evidence of DE by MRI: 4 (21.0%) patients with normal electrocardiogram (ECG) and normal echocardiogram (echo) (group 1); 3 (15.8%) patients with abnormal ECG and normal echo (group 2); and 12 (63.2%) patients with abnormal ECG and echo (group 3).. Results: In the 19 patients, there were 110 segments (34.1%) with DE identified using a 17-segment model. Pattern of involvement is as follows: endocardial 30 (27.3%), mid-myocardial 22 (20.0%), epicardial 2 (1.8%) and transmural 56 (50.9%). Most common territories of involvement are as follows (% of patients with segment involved): Basal inferolateral (78.9%), ...

Introduction: Left ventricular (LV) remodeling in Chagas heart disease (CHD) depends on the severity of the initial insult and may have clinical implication. SEARCH-Rio study investigated nonlinear dynamics in long-term LV remodeling in CHD.. Methods: Fifty stable outpatients with CHD were enrolled and followed at scheduled visits. Cardiac death (sudden, arrhythmic or heart failure) was ascertained by review of medical records. LV dimension was assessed by echocardiogram, and mass estimated by Devereux. Subjects were distributed in four equally spaced groups according to initial mass. Intra-group standard deviation (SD) was calculated throughout follow-up. A plot of LV mass (corrected to initial value) vs recurrences during follow-up assessed non-linear relationship. Lyapunov exponent (LE) assessed LV mass dynamics during follow-up.. Results: Median follow-up was 95 months; 10 subjects died. LV mass groups were [mean; Figure 1]: I-110g, II-140g, III-170g, IV-200g. No inter-group SD differences ...

Chagas´ disease is an endemy caused by the protozoa Trypanosoma cruzi, which is spread from southern United States to Argentina. According to data from the World Health Organization, up to 20 million people may be infected in South America, thus making this disease a very important public health problem. This disease occurs naturally in several animal species, despite data still lacks about natural infection in dogs. Thus, this work aimed to characterize Chagas´ disease of natural occurrence in three adult dogs from Western Brazil.. Animals were referred to the Cardiology Service of the Veterinary Teaching Hospital of São Paulo State University (Unesp), Campus of Jaboticabal, Brazil, where they were evaluated. After serologic testing by indirect immunofluorescence for Trypanosoma cruzi, dogs were considered positive to such disease, owing to the high positive titles: 1:2560, 1:1280 and 1:320. Moreover, it was also performed a serologic test to differentiate from Leishmaniasis, which was ...

BS, 1980, Kurukshetra University, India. Overview: Oxidative response networks and inflammation in Chagasic Cardiomyopathy; Vaccine efficacy against T. cruzi and Chagas disease; Strategies for the elimination of tropical infectious diseases. Research Interests Chagasic cardiomyopathy (CCM) is a major public health threat in Latin America and Mexico, and recognized as an emerging infectious disease in the U.S. Dr. Gargs research program focuses upon two major areas dealing with CCM pathogenesis and vaccine development. The studies in the first program are aimed at understanding a) the parasite-induced changes in gene regulation and the signaling cascade that contribute to myocardial cytoskeletal rearrangement and mitochondrial dysfunction; and b) the role of free radicals in initiation and/or sustenance of the pathological processes, i.e., inflammation, oxidative damage, and clinical severity of cardiac disease. A second program focuses on screening the T. cruzi genome and identifying of vaccine ...

Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON. (MeSH ...

Methods and Results Nineteen patients with CC undergoing detailed epicardial and endocardial LV tachycardia mapping and ablation were included. A total of 8494 epicardial and 6331 endocardial voltage signals and 314 epicardial/endocardial matched pairs of points were analyzed. Basal lateral LV scar involvement was observed in 18 of 19 patients. Bipolar voltage mapping demonstrated larger epicardial than endocardial scar and core-dense (≤0.5 mV) scar areas (28 [20-36] versus 19 [15-26] and 21 [2-49] versus 4 [0-7] cm2; P=0.049 and P=0.004, respectively). Bipolar epicardial and endocardial voltages within scar were low (0.4 [0.2-0.55] and 0.54 [0.33-0.87] mV, respectively) and confluent, indicating a dense/transmural scarring process in CC. The endocardial unipolar voltage value (with a newly proposed ≤4-mV cutoff) predicted the presence and extent of epicardial bipolar scar (P,0.001). ...

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Despite major advances in cardiovascular therapies, CHD still stands as an important cause of premature death in Latin America. Although the number of new cases of Chagas disease has decreased steadily since the late 1990s, many chronic cases are still part of routine care in public hospitals where patients with lower income have access to treatment. Moreover, decreased barriers to international travel and migration has led to an increase in migration of patients from Chagas disease-affected areas to nonendemic countries of North America and Europe. This globalization phenomenon transformed Chagas disease into a global medical challenge [39, 40].. CHD treatment is based on trials that studied the effect of different drugs on ventricular dysfunction, survival, and quality of life in patients with cardiomyopathies from other etiologies [4, 41]. However, CHD has a specific autonomic imbalance, a different pattern of myocardial fibrosis associated with an inflammatory milieu generated by parasite ...

Bautista-Lopez NL, Morillo CA, Lopez-Jaramillo P, Quuiroz R, Luengas C, Silva SY, Galipeau J, Lalu MM, Schulz R. (2013) Matrix metalloproteinase-2 and -9 as diagnostic markers in the progression to Chagas cardiomyopathy. Am Heart J 165:558-566. PMID: 23537973.. ZAHRAN, S., FIGUEIREDO, V., GRAHAM, M.M., SCHULZ, R., and HWANG, P.M. (2018). Proteolytic digestion of serum cardiac troponin I as a marker of ischemic severity. J Appl Lab Med. 3:450-455 ...

As we ring in the new year, the January 2018 issue of JASE debuts with Michael H. Picard, MD, FASE, as Editor-in-Chief, his first editorial, JASE 3.0: Entering our 4th Decade, and a new cover design! The issue also features Recommendations for Multimodality Cardiac Imaging in Patients with Chagas Disease: A Report from the American Society of Echocardiography in Collaboration With the InterAmerican Association of Echocardiography (ECOSIAC) and the Cardiovascular Imaging Department of the Brazilian Society of Cardiology (DIC-SBC). The writing group for this important paper was led by Harry Acquatella, MD, FACC, FAHA, FASE, MACP, of Centro Medico de Caracas in Caracas, Venezuela (Chair), one of the worlds foremost experts on Chagas heart disease and Federico Asch, MD, FASE, of MedStar Washington Hospital Center in Washington, DC (Co-chair). Dr. Asch commented, While historically it has been rare in the U.S., migration has changed the epidemiology of Chagas Heart Disease. However, there is ...

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RESUMEN. El objetivo de esta investigacion fue determinar compromiso cognitivo en pacientes con enfermedad de Chagas en estadio cronico. Se estudio el perfil cognitivo de 45 pacientes chagasicos cronicos (CC) y 26 controles apareados por edad, educacion, lugar y tiempo de residencia en area endomica. El Minimental State (MMSE), 1 a escala de memoria de Weschler (WMS) y el test de Inteligencia de Weschler (WAIS) han sido utilizados para evaluar ambos grupos. Para el estudio estadístico de los datos se utilizaron pruebas no paramotricas, Chi2 y estadistica multivariada en tabla de 2x2 para medir la association o independencia de variables categoriales con la presencia de enfermedad. Los resultados mostraron que los pacientes alcanzaban score menor que los controles en el MMSE (p,0.004) debido basicamente a una mas pobre orientacion (P,0.004) y atencion (p,0.007). Cocientes bajos de memoria en el WMS se asociaron a la presencia de enfermedad (Chi2 5.9, p,0.01; test de Fisher p,0.02). Cocientes ...

Rationale: Autoantibodies directed against the second extracellular loop of the cardiac beta1-adrenergic receptor (β1-AR) are thought to contribute to the pathogenesis of dilated cardiomyopathy (DCM) and Chagas heart disease. Various approaches have been employed to detect such autoantibodies; however, the reported prevalence varies largely depending on the utilized detection method. Objective: We analysed sera from 167 DCM patients (ejection fraction , 45%), and from 110 age-matched volunteers, who did not report any heart disease themselves, with an often employed simple peptide-ELISA approach, and compared it to a novel whole cell-based ELISA using cells expressing the full transgene for the human β1-AR. Additionally, 35 patients with hypertensive heart disease (HHD) with preserved ejection fraction were investigated. Methods and Results: The novel assay was designed according to the currently most reliable anti-TSH receptor antibody-ELISA used to diagnose Graves disease (third ...

The etiologies of cerebral infarcts have always been under scrutiny. As it stands today, about a third of strokes are still cryptogenic. The impact of stroke does not need to be emphasized to the audience of this blog. Despite staggering data with modern technological advances, a significant percentage of stroke patients remain a mystery. The solace is that we have made some advances, wherein I can introduce this hot topic of discussion: atrial cardiopathy.. The term atrial cardiomyopathy was first published in 1972, to describe a familial syndrome affecting the atria and atrioventricular system with resultant rhythm abnormalities. The term has percolated through the years, evolving in its definition. The current definition for atrial cardiopathy, created by the European Heart Rhythm Association, is the most accepted one: any complex structural, architectural, contractile or electrophysiological changes affecting atria with potential to produce clinically relevant manifestations. This suggests ...

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Destiné aux professionnels de la santé, Cardio-FR offre une aide précieuse au diagnostic et au traitement des principales maladies cardiovasculaires fréquentes.

A little-known disease called Chagas is much more prevalent than Zika. Heres how advocates fought an uphill battle, and won ...

Descrição: The aim of the present study was to assess the effects of an anticholinesterase agent, pyridostigmine bromide (Pyrido), on experimental chronic Chagas heart disease in mice. To this end, male C57BL/6J mice noninfected (control:Con) or chronically infected (5 months) with (chagasic:Chg) were treated or not (NT) with Pyrido for one month. At the end of this period, electrocardiogram (ECG); cardiac autonomic function; heart histopathology; serum cytokines; and the presence of blood and tissue parasites by means of immunohistochemistry and PCR were assessed. In NT-Chg mice, significant changes in the electrocardiographic, autonomic, and cardiac histopathological profiles were observed confirming a chronic inflammatory response. Treatment with Pyrido in Chagasic mice caused a significant reduction of myocardial inflammatory infiltration, fibrosis, and hypertrophy, which was accompanied by a decrease in serum levels of IFN with no change in IL-10 levels, suggesting a shift of immune ...

Trypanosoma cruzi (T. cruzi) infection reactivation is a constant threat for Chagas heart transplant recipients. The incidence of clinical T. cruzi infection reactivation varies from 27% to 90% and manifestsby paniculitis and/or myocarditis and more rarely by intracerebral Six (43%) out of 14 patients had documented T. cruzi infection reactivation: 3 in the heart, and 3 in the subcutaneous tissue. Six The histological aspect of myocardial T. cruzi infection reactivation (43%) patients had acute myocardial inflammation consistent with on endomyocardial biopsy usually mimics acute graft rejection. This acute rejection graded 3A or more, which had not improved with might lead to inadvertent treatment with steroid pulsotherapy, steroid pulsotherapy, but improved after specific treatment for dissemination of T. cruzi infection, or septicemia due to opportunistic T. cruzi infection (benznidazol, 5 mg/kg, during 60 days). Such The aim of this study, therefore, was to look for other risk factors for ...

Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.

Current diagnosis of chronic Chagas disease relies on serologic detection of specific immunoglobulin G against Trypanosoma cruzi. However, the presence of parasites detected by polymerase chain reaction (PCR) in patients without positive conventional serologic testing has been observed. We determined the prevalence and clinical characteristics of persons with seronegative results and T. cruzi DNA detected by PCR in a population at high risk for chronic American trypanosomiasis. We studied a total of 194 persons from two different populations: 110 patients were recruited from an urban cardiology clinic, and 84 persons were citizens from a highly disease-endemic area. Eighty (41%) of persons had negative serologic findings; 12 (15%) had a positive PCR. Three patients with negative serologic findings and positive PCR results had clinical signs and symptoms that suggested Chagas cardiomyopathy. This finding challenges the current recommendations for Chagas disease diagnosis, therapy, and blood ...

Current diagnosis of chronic Chagas disease relies on serologic detection of specific immunoglobulin G against Trypanosoma cruzi. However, the presence of parasites detected by polymerase chain reaction (PCR) in patients without positive conventional serologic testing has been observed. We determined the prevalence and clinical characteristics of persons with seronegative results for T. cruzi DNA detected by PCR in a population at high risk for chronic American trypanosomiasis. We studied a total of 194 persons from two different populations: 110 patients were recruited from an urban cardiology clinic, and 84 persons were nonselected citizens from a highly disease-endemic area. Eighty (41%) of persons had negative serologic findings; 12 (15%) had a positive PCR. Three patients with negative serologic findings and positive PCR results had clinical signs and symptoms that suggested Chagas cardiomyopathy. This finding challenges the current recommendations for Chagas disease diagnosis, therapy, and blood

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Although low-grade parasite persistence is a fundamental aspect of chronic Chagas disease, current parasitological assays have low sensitivity and are not quant...

This study investigated the efficacy and tolerability of low and high dose posaconazole versus benznidazole in patients with chronic Chagas disease. The primary

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This laboratory investigates the pathogenesis of chagasic heart disease, caused by the parasite Trypanosoma cruzi. Chagas disease is also an opportunistic infection in HIV/AIDS. We are examining signaling pathways involved in cardiac remodeling as a consequence of the T. cruzi infection. This laboratory is examining the consequences of this infection on cell cycle regulatory proteins (i.e., cyclins) in vitro. Previously, we found that infection induces ERK activation and modulation of the expression and/or activity of cyclins, which function as mediators of cellular proliferation and differentiation. Cyclins are also responsible for remodeling in the cardiovascular system. Therefore, the kinetics of the expression of cyclins in infected cultured cells and co-culture systems are to be studied. In addition, in the mouse model of Chagas disease the kinetics of expression of cell cycle regulatory proteins in the cells of the myocardium of infected mice will be determined and correlated with ...

Trypanosoma cruzi, the protozoan that causes Chagas heart disease, invades endothelial cells in vitro by activating the B-2 kinin receptor (B2R). Here, we demonstrate that mice infected with trypomastigotes develop potent edema after treatment with the angiotensin-converting enzyme (ACE) (or kininase II) inhibitor captopril. Experiments performed with specific kinin receptor (B2R/B1R) antagonists and knockout mice revealed that the early-phase (3-h) edema is mediated by the constitutive B2R, whereas the late-phase (24-h) response depends on stimulation of the up-regulated B1R. Given previous evidence that parasite invasion of cells expressing B2R is potentiated by captopril, we investigated the prerequisites for in vitro infection of Chinese hamster ovary cells overexpressing either B1R or B2R, human umbilical vein endothelial cells activated by lipopolysaccharide, and neonatal rat cardiomyocytes. Our results indicate that captopril potentiates parasite invasion regardless of the kinin ...

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here. ...

Background :Chagas disease is an endemic disease in most Latin American countries. The cardiomyopathy associated with this condition often requires permanent pacing due to bradycardia. The aim of this study was to compare the indications for pacemaker implantation, intraoperative measurements, and long-term follow-up of patients with Chagas cardiomyopathy (ChCM) and ischemic cardiomyopathy (ICM) referred for pacemaker implantation.. Methods : Retrospective study including consecutive patients with ChCM (Group 1) and ICM (Group 2), who underwent pacemaker implantation in a single center.. Results : We analyzed 360 patients. Patients in Group 1 were younger (66.29 ± 7.01 vs 75.3 ± 7.11 years; P = 0.0001) and more often male (72% vs 60%; P = 0.05). Sinus node dysfunction (SND) was more prevalent in Group 1 (70% vs 52%; P = 0.03). Atrioventricular block was less prevalent in Group 1 (30% vs 48%; P = 0.04). No significant differences were found with respect to left ventricular ejection fraction ...

Background Chagas disease induced by (invasion and in sponsor tissue fibrosis. become inhibited by this compound. Interestingly we further shown that administration of type:entrez-nucleotide attrs :text:GW788388″ term_id :293585730″ term_text :GW788388″GW788388 at the end of the acute phase (20 dpi) still significantly increased survival and decreased cardiac fibrosis (evaluated by Massons trichrome staining and collagen type I manifestation) inside a stage when parasite growth is no more central to this event. Summary/Significance This work confirms that inhibition of TGF? signaling pathway can be considered like a potential alternate strategy for the treatment of the symptomatic cardiomyopathy found in the acute and chronic phases of Chagas disease. Author Summary Cardiac damage and dysfunction are prominent features in individuals with chronic Chagas disease which is definitely caused by illness with the protozoan parasite (invasion and growth and in sponsor tissue fibrosis. ...

The evolution of Chagas cardiomyopathy is poorly understood. We therefore examined the development of cardiac lesions in a rural Brazilian community for a period of 7 years. Initially, 42% of 1017 residents were seropositive for infection with Trypa

Chagas disease is diagnosed using blood tests, but different kinds of blood tests are needed for acute and chronic Chagas disease.

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CDCs Division of Parasitic Diseases and Malaria (DPDM) provides essential information and services for healthcare providers and state and private labs around the country. When a healthcare provider is met with a difficult-to-diagnose parasitic disease, CDCs experts are available 24/7 to help out. Our real goal, though, is to help give physicians the knowledge they need to have Aha! I know what this is! moments when they encounter a Chagas disease patient.. We talk all the time to physicians who remember a Chagas disease lecture back in medical school but havent thought about it since, says Dr. Sue Montgomery, one of CDCs Chagas disease experts. At CDC, we provide confirmatory diagnoses for Chagas disease, make sure physicians have the information they need to correctly manage patients, and help them find the medicine their patients require.. ...

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At the SCMR meeting, Nagel was assigned to argue that everybody with COVID-19 should receive a CMR scan to check for myocardial damage.. He went over studies looking into myocardial damage in patients with COVID-19, noting that there are two phases to consider-acute and chronic. Its the latter, Nagel said, that the community will have to increasingly focus on as the pandemic drags on, to explore whether damage identified on CMR leads to problems like chronic cardiomyopathy and LV dysfunction.. Based on accumulated evidence, A COVID infection can harm the heart in the same way as . . . diabetes or long-standing hypertension, or even more, he said. So there is something going on which is not good. It doesnt mean they all have massive myocarditis. Were not talking about fulminant myocarditis. Were not talking about people who are going to have consequences from that very soon. But there is an effect.. The CMR findings do not relate strongly to symptoms, at least not early in the course of ...

Indefinite integral, definite integral, fundamental theorem of calculus, method of substitution, area between two curves. Inverse functions and their derivatives, exponential and logarithmic functions, inverse trigonometric functions. Indeterminate forms and lHôpitals Rule. Geometric series, compound interest, exponential growth and decay. Techniques of integration (integration by parts, rationalizing substitution, partial fractions), improper integrals. Differential equations (separable and first-order linear equations) and initial-value problems. Three-dimensional coordinate system, functions of several variables, partial derivatives, the chain rule. Maximum and minimum values, the second partials test, the method of Lagrange Multipliers. Double integrals. Credit units: 4 ECTS Credit units: 6.5, Prerequisite: MATH 105 ...

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Chagas disease is a potentially life threatening tropical illness that is caused by a parasite that is found on an insect known as the kissing bug. The estimates are that there are at least 10 million people worldwide, with at least 1 million in the US infected with Chagas disease…. Read more ...

Chagas is a deeply misunderstood disease that affects about eight million people around the world, primarily in Latin America, and is responsible for 10,000 deaths a year, according to the World Health Organization. It is estimated that 300,000 people in the United States have it, per the U.S. Centers for Disease Control and Prevention. … A majority of people with Chagas in the U.S. likely acquired it in one of 21 Latin-American countries … Research suggests many of the most at-risk people probably wont get care for the disease in America… (Smith, 8/29).. ...

World Chagas Day is tomorrow, April 14, 2018. This world health day is designed to raise awareness of a rarely talked about and frequently silenced disease. Chagas is considered silenced because its transmission is linked to poverty and its magnitude, even in the 21st century, is largely unknown.

Researchers used arrays with more than 175,000 peptides matching sections of the Chagas pathogen proteome to characterize novel elements of the immune response to infection.

At Sevenhills Wholefoods we have robust systems in place to ensure our product is safe for our customers to consume and is compliant with food regulations. Our product storage and freeze dying processes are at temperatures as low as -15°C which are too low for the Chagas parasite to survive. The product is also flash pasteurised to further ensure it is safe for consumption.. ...

Our NSF-funded EEID project seeks to halt Chagas transmission using evidence-based ecohealth approaches. Genomics and modeling inform control efforts.

\Trypanosoma cruzi\ é o agente etiológico da doença de Chagas, esta considerada um problema de saúde pública na América Latina. Cerca de 10 a 14 milhões de pessoas estão infectadas com o \Trypanosoma...

Cryopraxis laboratory is within their headquarters: Av. Carlos Chagas Filho, 791 Cidade Universitária - Rio de Janeiro - RJ - Brasil - 21.941-904

HAS ( ) DM ( ) Dislipidemia ( ) IRC ( ) DPOC/Pneumopatia ( ) Chagas ( ) IAM ( ) FR ( ) FA ( ) AVC ( ) Anemia ( ) Infec es Virais ( ) Claudica o ( ) Hiper/Hipotireoidismo ...