Cervical intraepithelial neoplasia grade 2 or 3 was confirmed by biopsy in 28 women. On the basis of survival analysis, the cumulative incidence of cervical intraepithelial neoplasia at two years was 28 percent among women with a positive test for HPV and 3 percent among those without detectable HPV DNA. The risk was highest among those with HPV type 16 or 18 infection (adjusted relative risk as compared with that in women without HPV infection, 11; 95 percent confidence interval, 4.6 to 26; attributable risk, 52 percent). All 24 cases of cervical intraepithelial neoplasia grade 2 or 3 among HPV-positive women were detected within 24 months after the first positive test for HPV. After adjustment for the presence of HPV infection, the development of cervical intraepithelial neoplasia was also associated with younger age at first intercourse, the presence of serum antibodies to Chlamydia trachomatis, the presence of serum antibodies to cytomegalovirus, and cervical infection with Neisseria ...
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer form forming, growing, or coming back. Vaccines may help the body build an effective immune response against human papillomavirus and may be effective in preventing cervical intraepithelial neoplasia or cervical cancer. It is not yet known whether human papillomavirus vaccine is more effective than hepatitis A vaccine in preventing cervical intraepithelial neoplasia or cervical cancer.. PURPOSE: This randomized phase III trial is studying human papillomavirus vaccine to see how well it works compared to hepatitis A vaccine in preventing cervical intraepithelial neoplasia or cervical cancer in younger healthy participants. ...
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer form forming, growing, or coming back. Vaccines may help the body build an effective immune response against human papillomavirus and may be effective in preventing cervical intraepithelial neoplasia or cervical cancer. It is not yet known whether human papillomavirus vaccine is more effective than hepatitis A vaccine in preventing cervical intraepithelial neoplasia or cervical cancer.. PURPOSE: This randomized phase III trial is studying human papillomavirus vaccine to see how well it works compared to hepatitis A vaccine in preventing cervical intraepithelial neoplasia or cervical cancer in younger healthy participants. ...
Human papillomavirus antigen was found in 39 (16%) of 253 colposcopic biopsies from a group of women at high risk for cervical cancer who had been examined in the early 1970s. Immunohistochemical evidence of papillomavirus infection was found in 20 (30%) of 67 cervical intraepithelial neoplasia lesions infected with wart virus from these patients. When these results were compared with results of a similar study carried out in the early 1980s there was no significant difference in the prevalence of human papillomavirus antigen in cervical intraepithelial neoplasia lesions infected with wart virus from women who had been examined over a decade apart.. ...
... (LSIL) - symptoms, causes and treatment. These are often a result of infections or by minor injuries undergoing
Thomas I., Wright G. and Ward B. (1990) The effect of condom use on cervical intraepithelial neoplasia grade I (CIN I). Australian and New Zealand Journal of Obstetrics and Gynaecology, 30 3: 236-239. ...
TY - JOUR. T1 - Age-related changes in pre- and post-conization HPV genotype distribution among women with high-grade cervical intraepithelial neoplasia. AU - Giannella, Luca. AU - Fodero, Cristina. AU - Boselli, Fausto. AU - Rubino, Teresa. AU - Mfuta, Kabala. AU - Prandi, Sonia. PY - 2017/4/1. Y1 - 2017/4/1. N2 - Objective: To assess the effect of age on pre- and post-conization HPV genotype distribution. Methods: The present retrospective observational study included consecutive women with high-grade cervical intraepithelial neoplasia who underwent conization at the Cervical Cancer Screening Centre of Reggio Emilia, Italy, and University Hospital of Modena, Italy, between February 1, 2012, and October 31, 2014. Pre-conization and 6-month post-conization HPV genotyping results were compared between four age groups (,30, 30-39, 40-49, and ≥50 years) and age-related changes in the HPV genotypes present were evaluated. Results: There were 162 patients included. The lowest occurrence of ...
TY - JOUR. T1 - Cervical nitric oxide metabolite levels and clinical variables as predictive factors of high-grade cervical intraepithelial neoplasia. AU - Giannella, Luca. AU - Prandi, Sonia. AU - Giulini, Simone. AU - Mfuta, Kabala. AU - Torrini, Barbara. AU - Boselli, Fausto. PY - 2013/11. Y1 - 2013/11. N2 - Purpose: To create a prediction model of high-grade cervical intraepithelial neoplasia (CIN) based on clinical variables and the cervical nitric oxide metabolite (NOx) levels of study participants. Methods: This comparative study included 694 women undergoing colposcopy due to abnormal pap smear results. On the basis of the cervical biopsy results, the women were divided into the ≤CIN 1 or CIN 2-3 group. The two groups were compared in terms of cervical NOx levels and clinical variables. Univariate, multivariate, and receiver-operating characteristic curve analysis were performed. Results: Multivariate analysis showed that CIN 2-3 associated with more than two cervical biopsies [odds ...
Description: Cervical Intraepithelial Neoplasia (CIN) - Pipeline Review, H1 2017, provides an overview of the Cervical Intraepithelial Neoplasia (CIN) (Wom
Source: Department of Pathology, The Norwegian Radium Hospital and Institute for Cancer Research, University of Oslo, Montebello.. Abstract:. A significant higher incidence of some cancers, especially lung cancer, has been found in women with previous HPV-related (human papillomavirus) urogenital and anal neoplasias than in individuals without this particular clinical history. The aim of our study was to investigate whether HPV is present in both CIN III (cervical intraepithelial neoplasia) lesions and bronchopulmonary second primary cancers in women with a clinical history of both diseases. Paraffin-embedded tumour tissue from 75 patients with bronchopulmonary carcinomas was examined using the polymerase chain reaction (PCR) technique and in situ hybridization for the presence of human HPV. In total, 51 primary tumours without metastases, 11 primary tumours with metastases and 13 lymph node metastases without available tissue from primary tumours were analysed. In our study 37/75 primary ...
AIM: To determine the frequency of cervical intraepithelial neoplasia (CIN) following large loop excision of the transformation zone of the cervix (LLETZ) according to grade and completeness of excision of CIN. METHODS: A retrospective study of 669 patients who had LLETZ biopsies showing CIN 1, 2, or 3. The patients were subdivided according to the grade and completeness of excision of CIN. The follow up period was 1.5 to 3.5 years. Risk of persistent/recurrent CIN was assessed by the frequency of histological diagnosis of CIN during the follow up period. RESULTS: Frequency of persistent/recurrent CIN increased with the grade of CIN reported: 6.7% of patients with CIN 1, 13.4% with CIN 2, and 21.7% with CIN 3 developed persistence or recurrence. The frequency of CIN persistence/recurrence was significantly lower where LLETZ showed complete excision of CIN (8.4%) than where it was incomplete (31.3%) (p , 0.0001) or equivocal (27.8%) (p , 0.0001). CONCLUSIONS: Patients with incomplete or equivocal ...
Abstract. Background: Atypical squamous cell cannot exclude high-grade squamous intraepithelial lesion (ASC-H) and low-grade intraepithelial lesion cannot exclude high-grade squamous intraepithelial lesion (LSIL-H) are ambiguous diagnostic entities for the prediction of high-grade cervical lesion. Objective and reproducible tests for predicting high-grade cervical lesions are needed to reduce unnecessary colposcopic referrals or follow-ups.. Objective: We aimed to identify an adequate set of adjunctive markers to predict cervical intraepithelial neoplasia grade 2+ (CIN2+) in residual liquid-based cytology specimens (LBCS).. Methods: We conducted p16 INK4a/Ki-67 and L1 capsid protein immunostaining and human papillomavirus (HPV) DNA typing on 56 LBCS diagnosed with ASC-H or LSIL-H, all of which were subjected to histologic confirmation or follow-up cytologic examination.. Results: Positivity for p16 INK4a/Ki-67 was associated with a histology of CIN2+ (P=0.047) and CIN3+ (P=0.002). Negativity for ...
Initially submitted June 1, 2009; accepted for publication August 5, 2009.. Correspondence to Dr. Philip E. Castle, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 5004, MSC 7234, Bethesda, MD 20892-7234 (e-mail: [email protected]).. Misclassification of exposure and surrogate endpoints of disease can obscure causal relations. Using data from the Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesion Triage Study (ALTS, 1997-2001), the authors explored the impact of exposure (human papillomavirus (HPV) detection) and endpoint (histologic cervical precancer) classification on their mutual association. Women referred into this study with an atypical squamous cells of undetermined significance Papanicolaou test with satisfactory results for all 4 HPV tests were included in this analysis (n ¼ 3,215; 92.2%). HPV testing results were related to differentdefinitions of cervical precancer, based on ...
Results Overall, 2790 women (6.9%) tested positive for LR-HPV types, with HPV6 and HPV70 being the most frequent types detected, whereas HPV11 was uncommon. The highest prevalence was observed in the youngest age group (≤19 years). The LR-HPV prevalence was 6.3% in women with normal cytology, 33.1% in atypical squamous cells of undetermined significance (ASCUS), 19.6% in low-grade squamous intraepithelial lesion and 12.7% in those with high-grade squamous intraepithelial lesion. When considering women with LR-HPV alone, the prevalence was 2.0% (normal cytology), 11.3% (ASCUS), 2.6% (low-grade squamous intraepithelial lesion) and 0.7% in women with high-grade squamous intraepithelial lesion, respectively. A similar pattern was observed in relation to the histological diagnoses with the majority of LR-HPV infections detected in CIN1 lesions (24.7%).. ...
Background: The ALTS (atypical squamous cells of undetermined significance [ASCUS] and low-grade squamous intraepithelial lesion [LSIL] Triage Study) suggests that, for women diagnosed with ASCUS, human papillomavirus (HPV) DNA testing followed by referral to colposcopy of only those women with oncogenic HPV (i.e., HPV DNA testing) is as effective at detecting cervical intraepithelial neoplasia (CIN) 3 or cancer (CIN3+) as referring all women with ASCUS for immediate colposcopy. We conducted a cost-effectiveness analysis of the ALTS trial to determine whether HPV DNA testing is a cost-effective alternative to immediate colposcopy or conservative management with up to three cytology examinations. Methods: Data from the ALTS trial were used in conjunction with medical care costs in a short-term decision model. The model compared the incremental costs per case of CIN3+ detected as measured by the incremental cost-effectiveness ratio (ICER) for the following management strategies for women with ...
Background: Women infected with human immunodeficiency virus type 1 (HIV-1) and -2 may be at higher risk of developing cervical cancer than uninfected women. We assessed the relationships among human papillomavirus (HPV) types and persistence, HIV-1 and/or HIV-2 infection, and the development of high-grade cervical squamous intraepithelial lesions (HSILs) in a prospective study. Methods: We studied 627 women with and without HIV-1 and/or HIV-2 infection and high-risk HPV infection in Senegal, West Africa, who were assessed every 4 months for HSIL and HPV DNA over a mean follow-up of 2.2 years. Cox regression modeling was used to assess risks associated with development of HSIL. Results: During follow-up, 71 (11%) of 627 women developed HSIL as detected by cytology. HIV-infected women with high-risk HPV types were at greatest risk for development of HSIL. In multivariable modeling, infection with oncogenic HPV types-both persistent (hazard ratio [HR] = 47.1, 95% confidence interval [CI] = 16.3 to ...
Sponsor. American College of OB/GYN. Principal Investigator. Dr. Lisa Rahangdale, Obstetrics and Gynecology. Project Run Dates. 7/1/2010 to 7/31/2013. Summary. Cervical cancer is the 3rd leading cause of cancer worldwide. Human papillomavirus (HPV) infection is the precursor to cervical dysplasia and cancer. Though the majority of HPV infections are cleared by the bodys immune system, cervical dysplasia that persists and progresses to Cervical Intraepithelial Neoplasia 2/3 (CIN 2/3 or moderate/severe dysplasia) requires repeated cytologic screening, biopsies or excisional/ablative therapy. The management of CIN 2 is particularly challenging as nearly half of these lesions regress, particularly in young women. However, approximately one third will persist and the remaining may progress to CIN 3. We currently are not able to predict which lesions will regress, persist, recur or advance. As a result, providers are compelled to treat women surgically since there are currently no medical therapies ...
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TY - JOUR. T1 - Outcomes after an excisional procedure for cervical intraepithelial neoplasia in HIV-infected women. AU - Reimers, Laura L.. AU - Sotardi, Susan. AU - Daniel, David. AU - Chiu, Lydia G.. AU - Van Arsdale, Anne R.. AU - Wieland, Daryl L.. AU - Leider, Jason M.. AU - Xue, Xiaonan (Nan). AU - Strickler, Howard. AU - Garry, David J.. AU - Goldberg, Gary L.. AU - Einstein, Mark H.. PY - 2010/10. Y1 - 2010/10. N2 - Objective: To determine predictors of treatment failure and recurrence after surgical excisional procedures for CIN in HIV-infected women. Methods: A retrospective cohort study was conducted in which 136 eligible HIV-infected women treated for CIN between 1999 and 2005 were included. Data were abstracted from charts and computer databases. Treatment failures were defined as the presence of CIN 1+ at initial follow-up. Recurrences were defined as the presence of CIN 1+ subsequent to initial normal follow-up. Results: Treatment failure at initial follow-up was common, ...
Cervical Intraepithelial Neoplasia (CIN) is a precursor to invasive cervical cancer, which annually accounts for about 3700 deaths in the United States and about 274,000 worldwide. Early detection of CIN is important to reduce the fatalities due to cervical cancer. While the Pap smear is the most common screening procedure for CIN, it has been proven to have a low sensitivity, requiring multiple tests to confirm an abnormality and making its implementation impractical in resource-poor regions.
low-grade squamous intraepithelial lesion (lgsil) is a type of precancerous changes in the cervix. these lesions may go away on their own, but over time, they may become more abnormal, eventually beco
The present primary therapy of cervical intraepithelial neoplasia (CIN) grade 3 and persistent CIN 2 represents conisation. Surgical treatment can cause
Our findings suggest that women with a first cytological diagnosis of atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesion up to age 27 years may indeed be safely followed up with repeat cytology within 6 months. A large amount of colposcopies that are curre …
HIV-infected adolescent females should be referred for colposcopy if they have any of the following: squamous intraepithelial lesion (SIL), low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL), or atypical squamous cells-cannot exclude a high grade intraepithelial lesion (ASC-H). For HIV-infected adolescent females with atypical squamous cells of undetermined significance (ASC-US), either immediate referral to colposcopy or repeat cytology in 6-12 months is recommended. If ASC-US or greater is found on repeat cytology, referral to colposcopy is warranted (BIII). Use of HPV testing is not recommended for screening or for triage of HIV-infected women with abnormal cytology results or follow-up after treatment (BIII) ...
Investigator] Cruickshank M; Murray G; Parkin D; Smart L; Walker E; Waugh N; Avis M; Chilvers C; Fielding K; Hammond R; Jenkins D; Johnson J; Neal K; Russell I; Seth R; Whynes D; Duncan I; Robertson A; Little J; Sharp L; Russell I; Walker L; Anthony B; Bell S; Bowie A; Brown K; Brown J; Chew K; Cochran C; Cotton S; Dean J; Dunn K; Edwards J; Evans D; Fenty J; Finlayson A; Gallagher M; Gray N; Heddle M; Innes A; Jobson D; Keillor M; MacGregor J; Mackenzie S; Mackie A; McPherson G; Okorocha I; Reilly M; Rodgers J; Thornton A; Yeats R; Alexander L; Buchanan L; Henderson S; Iterbeke T; Lucas S; Manderson G; Nicol S; Reid G; Robinson C; Sandilands T; Adrian M; Al-Sahab A; Bentley E; Brook H; Bushby C; Cannon R; Cooper B; Dowell R; Dunderdale M; Gabrawi; Guo L; Heideman L; Jones S; Lawson S; Philips Z; Platt C; Prabhakaran S; Rippin J; Thompson R; Williams E; Woolley C; Boroujerdi M; Cotton S; Harrild K; Norrie J; Day N; Marteau T; Parmar M; Patnick J; Woodman C; Altman D; Moss S; Wells M; Sharp L; ...
Results Prevalence of cervical infections with any of the 25 LR-HPV types was 10.0% (95% CI: 8.1%-11.9%) and with exclusively LR-HPV types 4.5% (95% CI: 3.2%-5.8%). Prevalence of infections with any LR-HPV types among women with normal cytology was 8.8%, with atypical squamous cells of undetermined significance (ASC-US) 30.4%, with low grade squamous intraepithelial lesions (LSIL) 60.0%, and with high grade squamous intraepithelial lesions (HSIL) 7.7%. LR-HPV types without coexisting HR-HPV types were found in 4.0% of women with normal cytology, 26.1% with ASC-US, 6.7% with LSIL, and none with HSIL. Infections with exclusively HPV 6 or HPV 11 were not found.. ...
In a meta-analysis reported in The Lancet Oncology, Arbyn et al found that posttreatment high-risk human papillomavirus (HPV) testing was a better predictor of recurrence of high-grade cervical intraepithelial neoplasia of grade 2 or higher (CIN2+) than incomplete cervical excision.. Study Details. The meta-analysis included 97 studies, from a literature search covering January 1975 to February 2016, representing a total of 44,446 women treated for cervical precancer. The studies were eligible if patients had undergone treatment by excision of a histologically confirmed CIN2+ lesion with verification of the presence or absence of cervical intraepithelial neoplasia at the resection, were tested by cytology or HPV assay between 3 months and 9 months after treatment, and had subsequent follow-up of at least 18 months posttreatment including histologic confirmation of the occurrence of CIN2+. Treatment failure associated with marginal status was defined as occurrence of residual or recurrent ...
TY - JOUR. T1 - The expression of type I growth factor receptors in the squamous neoplastic changes of uterine cervix. AU - Chang, Junn Liang. AU - Tsao, Yeou Ping. AU - Liu, Dai Wei. AU - Han, Chih Ping. AU - Lee, Wei Hwa. AU - Chen, Show Li. PY - 1999/4. Y1 - 1999/4. N2 - Aim. The type I family of growth factor receptors includes ErbB1, ErbB2, ErbB3, and ErbB4 which are frequently overexpressed in various human cancer cells. In this study, we systematically investigated the frequency and distribution of these four receptors in relation to neoplastic changes and tumor behaviors in the uterine cervix. Materials. A total 84 of cases including 12 cases of normal cervical tissues, 6 cases of low grade squamous intraepithelial lesion, 10 cases of high grade squamous intraepithelial lesion, and 56 cases of squamous cells carcinoma were examined. Results. Our results show significant difference with increasing grades of dysplasia in terms of these four receptor expressions. No association was found ...
... is a chapter in the book, Gynecology, containing the following 18 pages: Anti-Mullerian Hormone, Markers of Ovarian Reserve, Breast Cancer Gene Marker, BRCA1, BRCA2, Pap Smear, Benign Pap Smear Changes, Atypical Squamous Cells of Undetermined Significance, Low Grade Squamous Intraepithelial Lesion, High Grade Squamous Intraepithelial Lesion, AGUS Pap Smear, Inadequate Pap Smear, Serum Estradiol, Serum Progesterone, Mid-Luteal Serum Progesterone, Progesterone Challenge Test, Estrogen-Progesterone Challenge Test, Vaginal pH.
The aim of this research was to study the correlation between tissue tumor marker expression and HR-HPV infection, smoking, hormonal contraceptive use and sex steroids in women with cervical intraepithelial neoplasia or normal epithelium. The study investigated the expression of 11 tumor markers in cervical biopsies obtained from 228 women with different diagnoses ranging from normal cervical epithelium to various stages of CIN. 188 women were recruited at our colposcopy clinic (out-patient surgery, Department of Obstetrics and Gynecology, Falun Hospital) for laser cervical conization or a directed punch biopsy, either because of a vaginal smear (Pap smear) that showed cytological findings suggesting CIN, or because of repeated findings showing atypical squamous cells of undetermined significance (ASCUS). For 40 volunteers, punch biopsies were taken from the normal cervical epithelium. The time period for this study was 2005-2007.. Study I : 228 women, of whom 116 were tested, 64 were positive ...
Recent literature data suggest that the high-risk human papillomaviruses (HR-HPVs) testing with several molecular techniques could be an alternative to cytology in the detection of cervical intraepithelial neoplasias of grade 2 or worse (CIN2+). However, any molecular techniques have its own limits and may give false negative results which must be clearly known before undertaking a primary HPV screening. This study aims to evaluate the performance of the high-risk HPV hybrid capture II detection kit (HCII) which is considered as a “gold standard technique” in a series of 100 women having proved both cytological lesions of atypical squamous cells-cannot exclude an HSIL (ASC-H) or high-grade squamous intraepithelial lesion (HSIL) and histological lesions of CIN2+. The clinical sensitivity of HCII in women with a cytological diagnosis of ASC-H/HSIL and a diagnosis of CIN2+ is high but not absolute and estimated at 96% (95,6% and 100% of women with a diagnosis of CIN2/3 or
There is evidence that testing for HPV E6/E7 mRNA is more specific than testing for HPV DNA. A retrospective study was carried out to evaluate the performance of the PreTect HPV-Proofer E6/E7 mRNA assay (Norchip) as a triage test for cytology and HPV DNA testing. This study analyzed 1201 women, of who 688 had a colposcopy follow up and 195 had histology-confirmed high-grade intraepithelial neoplasia or worse (CIN2+). Proportion of positive results and sensitivity and specificity for CIN2+ were determined for HPV mRNA in comparison with HPV DNA and cytology. All data were adjusted for follow-up completeness. Stratified by cytological grades, HPV mRNA sensitivity was 83% (95%CI 63-94%) in ASC-US (Atypical Squamous Cells of Undetermined Significance), 62% (95%CI 47-75%) in L-SIL (Low-grade Squamous Intraepithelial Lesion), and 67% (95%CI 57-76%) in H-SIL (High-grade Squamous Intraepithelial Lesion). The corresponding figures were 99%, 91%, and 96%, respectively, for HPV DNA. The specificities were ...
The ability to derive a causal link between vaginal microbiota and HPV infection and CIN/cervical cancer is limited by the cross-sectional nature of most studies undertaken in this area. This difficulty is further compounded by the slow natural history of the disease, with time from acute HPV infection to high-grade CIN taking years to decades. In addition, numerous other confounders can impact results including smoking [46] and vaginal intercourse without the use of barrier contraception [47], which have both been associated with depletion of Lactobacillus spp. The impact of other sexual practices such as oral intercourse, use of lubricants and having multiple sexual partners is poorly understood, and the information gathered in the current observational studies is very heterogeneous as highlighted in Table 1. This information may represent major confounders affecting the VM composition as well as the presence of oncogenic HPV infections and should be clearly documented in future ...
Background: DNA ploidy analysis of cervical intraepithelial neoplasia (CIN) and invasive cervical cancer samples by flow cytometry (FCM) has been established as an aid to prognostic assessment. Liquid based cytology (LBC) increases diagnostic specificity by using ancillary techniques that provide information beyond morphology. The present study was undertaken to assess DNA ploidy in LBC samples as an adjunct for early detection of cervical pre-cancer and cancer. Methods: DNA ploidy assessment was performed on LBC samples of 50 cases and 31 controls. Cell pellets were obtained by centrifugation and stained with Telford reagent. At least 20,000 R1 gate (G0-G1) events were acquired on a BD FACSCalibur by using a 575±10 nm filter. Results: Mean diploid G1 values were lowered significantly (p|0.01) while diploid S values were significantly elevated (p|0.01) in both high grade squamous intraepithelial lesions (HSILs) and squamous cell carcinomas (SCCs) as compared to controls. Receiver operating curve (ROC
T-cell-mediated immune responses against mucosal oncogenic types of human papillomaviruses (HPV) are thought to play a role in the control of the virus infection and its associated cervical lesions. The in vitro production of interleukin-2 by T-helper (Th) cells in response to the C-terminal and N-terminal domains of the HPV-16 E2 protein was determined in 74 women with cytological evidence of premalignant cervical epithelial neoplasia who participated in a non-intervention follow-up (FU) study. Cross-sectional analysis at the end of FU showed that Th cell responses against the C-terminal domain were associated with evidence of previous or present HPV-16 infection as compared to patients with no evidence of any HPV infection (18·9% versus 0%, P=0·039). Th cell responses against the N-terminal domain were not associated with evidence of HPV-16 infection. No association with disease outcome was observed with Th cell responses against either of the E2 protein domains. However, longitudinal analysis
Of all the lesions, HPV 16 was the most frequent genotype. This finding is in accordance with many other studies carried out worldwide [20]. In our study, this genotype was present in 35.3% of total lesions. However, in a previous study carried in our hospital from 1993 to 2000, the HPV 16 presence in the total number of lesions was somewhat higher than at present (39%) [21]. Also, in a recent study carried in a southern region of Spain from 2006 to 2007, this presence was even lower than ours (21.2%) [17].. As expected, HPV16 presence increased in accordance with the grade of the lesion (15.8% in benign lesions, 26.1% in CIN1 cases, 56.3% in CIN2-3 cases and 71.4% in ICC).. HPV 31 was the second most frequent genotype in CIN1 lesions and in CIN2-3 lesions. In a study carried in an eastern region of Spain, HPV 31 was also the second most frequent genotype in HSIL lesions and the presence found in these (10.8%) was very similar to the presence obtained in our study (10.8%) [19]. Previous ...
A-007 is an investigational therapy which may be effective in the treatment of pre-cancerous cervical dysplasia (abnormal cell growth). The purpose of t
Nucleolar organising regions in cervical intraepithelial neoplasia.: The variations in the numbers of nucleolar organising regions (NORs) among different grades
en] Purpose: Infection with oncogenic human papillomavirus (HPV) and HPV-16 in particular is a leading cause of anogenital neoplasia. High-grade intraepithelial lesions require treatment because of their potential to progress to invasive cancer. Numerous preclinical studies have demonstrated the therapeutic potential of E7-directed vaccination strategies in mice tumour models. In the present study, we tested the immunogenicity of a fusion protein (PD-E7) comprising a mutated HPV-16 E7 linked to the first 108 amino acids of Haemophilus influenzae protein D, formulated in the GlaxoSmithKline Biologicals adjuvant AS02B, in patients bearing oncogenic HPV-positive cervical intraepithelial neoplasia (CIN). Methods: Seven patients, five with a CIN3 and two with a CIN1, received three intramuscular injections of adjuvanted PD-E7 at 2-week intervals. Three additional CIN1 patients received a placebo. CIN3 patients underwent conization 8 weeks postvaccination. Cytokine flow cytometry and ELISA were used ...
1. Deng Z, Hasegawa M, Yamashita Y, Matayoshi S, Kiyuna A, Agena S. et al. Prognostic value of human papillomavirus and squamous cell carcinoma antigen in head and neck squamous cell carcinoma. Cancer Sci. 2012;103:2127-34 2. Jin T, Wu X, Yang H, Liu M, He Y, He X. et al. Association of the miR-17-5p variants with susceptibility to cervical cancer in a Chinese population. Oncotarget. 2016;7(47):76647-55 3. Origoni M, Salvatore S, Perino A, Cucinella G, Candiani M. Cervical Intraepithelial Neoplasia (CIN) in pregnancy: the state of the art. Eur Rev Med Pharmacol Sci. 2014;18(6):851-60 4. Sharma A, Rajappa M, Saxena A, Sharma M. Cytokine profile in Indian women with cervical intraepithelial neoplasia and cancer cervix. Int J Gynecol Cancer. 2007;17(4):879-85 5. Yoqev O, Williams VC, Hinits Y, Huqhes SM. IF4EBP3L acts as a gatekeeper of TORC1 in activity-dependent muscle growth by specifically regulating Mef2ca translational initiation. PloS Biol. 2013;11(10):e1001679 6. Lee M, Kim EJ, Jeon MJ. ...
Squamous cell carcinoma of the cervix is the most common malignancy of the female genital tract worldwide, however, due to successful screening efforts, it is only the third most common malignancy of the female genital tract in the United States. There are approximately 233,000 deaths per year from this disease worldwide, versus 4800 deaths in the United States. It is now firmly established that HPV is the main causal agent, especially HPV type 16. Pre-malignant lesions include LGSIL (low-grade squamous intraepithelial lesions) and HGSIL (high-grade squamous intraepithelial lesions). ...
Burks HR; Smith KM; Wentzensen N; Tenney ME; Tuller E; Moxley K; Mathews C; Dunn ST; Wang SS; Gold MA. Risk of Cervical Intraepithelial Neoplasia 2+ Among Women with a History of Previous Treament for Cervical Intraepithelial Neoplasia; ASCUS and LSIL Pap Smears After Treatment. Journal of Lower Genital Tract Disease. 2011; 15(1): 11-14 ...
The diagnostic region of interest (ROI) from immediately adjacent sections were imaged, and the basal lamina and surface of the superficial layer were delimited. Nonoverlapping quantitatively stained nuclei were selected from 1,190 samples with histopathological characteristics of normal (929), koilocytosis (130), CIN 1 (40), CIN 2 (23), and CIN 3/carcinoma in situ (CIS) (68). A fully automatic procedure located and recorded the center of every nucleus in the region of interest (ROI). We used linear discriminant analysis to assess the changes between normal and CIN 3/CIS. ...
Background Cervical cancer is the second most common cancer among women. In developing countries, more than 88% deaths from cervical cancer occur. Cancer incidence and mortality are higher among...
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of cancer or to treat early cancer. SGN-00101 may be effective
This phase 2a, open-label, dose-rising study is evaluating the safety, tolerability, and preliminary efficacy of three concentrations of SOR007 ointment (0.15%,
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abnormal growth of cells of the uterine cervix, suggesting an early stage of cervical cancer. Human papillomavirus (HPV) and HIV infection are associated with an increased risk of CIN. There are 3 grades of severity: CIN I, CIN II and CIN III. A newer classification system divides these 3 classes into 2 categories: low-grade and high-grade squamous intraepithelial lesion (SIL). See also cervical dysplasia, squamous intraepithelial lesion ...
What is CIN? - Female Cancers: the facts - What is cervical intraepithelial neoplasia (CIN)? The presence of abnormal cells in the cervix are usually caused by changes in the squamous cells of the cervix. This is known as cervical intra-epithelial neoplasia (CIN)...