We previously reported that major depression developing during or after the presenile period is frequently combined with silent cerebral infarction and that these patients have a high risk of stroke. Therefore, we investigated whether the background factors and clinical symptoms of patients with major depression with silent cerebral infarction [SCI(+)] different from those in patients with major depression without silent cerebral infarction [SCI(-)] before medical treatment.. Patients with major depression with onset after 50 years of age were classified based on magnetic resonance imaging findings into the SCI(+) (n = 37) or SCI(-) (n = 20) group. The diagnostic criteria for major depression were those of the American Psychiatry Association (DSM-III-R). Patients with stroke or focal neurological symptoms were excluded. The SCI(+) group was subclassified according to whether the infarction area was perforating, cortical, or mixed artery. Family history of affective disorder, risk factors for ...
Background: Atherosclerotic middle cerebral artery (MCA) disease may produce subcortical infarction either in the upper part (corona radiata, CR) or in the lower area (internal capsule, IC) of the pyramidal tract. The study aimed to see whether the location of MCA stenosis (proximal vs distal) determines the location of subcortical infarction.. Methods: 62 consecutive patients who developed an acute (,72 h) infarction either on the CR or IC confirmed by diffusion-weighted MRI due to corresponding focal MCA M1 stenosis assessed by MR angiography were studied. The distance between the MCA origin and the centre of stenotic portion (S) and that between the MCA origin and its bifurcation site (M) were measured. Based on the S/M ratio, stenotic lesions were divided into "proximal and "distal. The relationship between the location of arterial stenosis and the location of infarcts was analysed.. Results: Thirteen of 31 patients (41.9%) with proximal M1 stenosis had IC lesions, while 26 (83.9%) of 31 ...
TY - JOUR. T1 - Mortality in Acute Cerebral Infarction in Young Adults-A Ten-Year Experience. AU - Biller, José. AU - Adams, Harold P.. AU - Bruno, Askiel. AU - Love, Betsy B.. AU - Marsh, E. Eugene. PY - 1991/1/1. Y1 - 1991/1/1. N2 - We reviewed the one-month mortality among 213 patients aged fifteen to forty-five years (mean thirty-five) with acute cerebral infarction (CI) evaluated during the period July 1, 1977, to February 1, 1988. Atherosclerotic cerebral infarction (ACI) was diagnosed in 59 (27.7%) patients, 53 (24.9%) had non- atherosclerotic vasculopathies (NAV); 46 (21.6%) had cardioembolic infarcts (CEI). Hematologically related disorders were diagnosed in 30 (14.1%) patients; the cause of CI could not be established in 25 (11.7%) patients. Fourteen patients (9 men, 5 women, mean age 34.8 years), (6.6%) died within thirty days of their CI: 7 had CEI (7/46, 15.2%); 4 had ACI (4/59, 6.7%); and 3 had NAV (3/53, 5.6%). Our data suggest that young patients with acute CI have a thirty-day ...
Aim. The aims of the study were to evaluate prevalence of silent cerebral infarctions (SCI) and determine their clinical and echocardiographic predictors in patients with atrial fibrillation (AF). Patients and methods. In prospective cross sectional study we examined 134 patients with non-valvular AF. Clinical examination, laboratory tests, transoesophageal, transthoracic echocardiography and multislice computed tomography of the brain were performed for all patients. According to current guidelines, SCI was defined as imaging (≥3 mm) or neuropathological evidence of central nervous system infarction, without a history of acute neurological dysfunction attributable to the lesion. Results. Silent cerebral infarctions were detected in 34.3% (n = 46) of patients, and infarctions ≥ 15 mm (mean diameter 31.3 mm) were detected in 11.2% (n = 15) of patients. Superficial SCIwere found in 12.7%and basal SCI in 21.6% of cases. In multivariate analysis low creatinine clearance , 90 ml/min was ...
A cerebral infarction is a type of ischemic stroke resulting from a blockage in the blood vessels supplying blood to the brain. It can be atherothrombotic or embolic. Stroke caused by cerebral infarction should be distinguished from two other kinds of stroke: cerebral hemorrhage and subarachnoid hemorrhage. A cerebral infarction occurs when a blood vessel that supplies a part of the brain becomes blocked or leakage occurs outside the vessel walls. This loss of blood supply results in the death of tissue in that area. Cerebral infarctions vary in their severity with one third of the cases resulting in death. ...
A cerebral infarction is a type of ischemic stroke resulting from a blockage in the blood vessels supplying blood to the brain. It can be atherothrombotic or embolic. Stroke caused by cerebral infarction should be distinguished from two other kinds of stroke: cerebral hemorrhage and subarachnoid hemorrhage. A cerebral infarction occurs when a blood vessel that supplies a part of the brain becomes blocked or leakage occurs outside the vessel walls. This loss of blood supply results in the death of tissue in that area. Cerebral infarctions vary in their severity with one third of the cases resulting in death. ...
A previous study suggested that occlusive diseases of small penetrating arteries account for most anterior choroidal artery (AChA) territory infarcts, but half of the patients did not have an echocardiogram. Cases of AChA territory infarcts associated with internal carotid artery stenosis or atrial fibrillation suggest that this hypothesis may be wrong. The aim of this study was to determine the mechanism of 16 nonselected consecutive AChA territory infarcts.. The study population consisted of 8 men and 8 women aged 17 to 89 years. They underwent a computed tomographic scan at the acute stage, Doppler ultrasonography and B-mode echotomography of the cervical arteries, bidimensional transthoracic echocardiography, and cerebral magnetic resonance imaging, replaced by a second computed tomographic scan in 3 patients. Ten patients underwent cerebral angiography. We defined the presumed cause of stroke according to the criteria used in the trial of Org 10172 in acute stroke treatment.. The presumed ...
OBJECTIVE: To assess various aspects of visual function at school age in children with neonatal cerebral infarction. PATIENTS AND METHODS: Sixteen children born at term, who had cerebral infarction of perinatal onset on neonatal magnetic resonance imaging (MRI) were assessed using a battery of visual tests. This included measures of crowding acuity (Cambridge Crowding Cards), stereopsis (TNO test), and visual fields. The results of the visual assessment were compared with the type and the extent of the lesion observed on neonatal MRI. RESULTS: Only six of the 16 children (28%) had some abnormalities of visual function on these tests. Visual abnormalities were more common in children with more extensive lesions involving the main branch of the middle cerebral artery and were less often associated with lesions in the territory of one of the cortical branches of the middle cerebral artery. The presence of visual abnormalities was not always associated with the involvement of optic radiations or occipital
Previous chronic cerebral infarction is predictive for new cerebral ischemia after carotid endarterectomy. - Mehmet Besir Akpinar, Veysel Sahin, Neslin Sahin, Ahmet Feyzi Abacilar, İlker Kiris, Ihsan Sami Uyar, Faik Fevzi Okur
Cerebral infarction is a major contributor to poor outcome after subarachnoid hemorrhage (SAH). While usually considered a complication of delayed cerebral ischemia (DCI), infarcts may also occur early, in relation to initial brain injury or aneurysm
Background: The role of each nitric oxide synthase (NOS) isoform in the pathogenesis of cerebral infarction has been studied in individual NOS isoform-deficient mice. It has been reported that, in a model of middle cerebral artery occlusion (MCAO), neuronal and inducible NOSs exacerbate cerebral infarction, whereas endothelial NOS conversely alleviates cerebral infarction. Although the role of the whole NOSs system in cerebral infarction has been examined in pharmacological studies with non-selective NOS inhibitors, the results are quit inconsistent, possibly because of non-specificity of the agents. In this study, we addressed this point in mice in which all three NOS genes are completely disrupted.. Method and Results: We newly generated triple NOSs-deficient mice and wild-type littermates by crossbreeding single NOS-/- mice. Transient (1 hour) and permanent MCAO was performed in male triple NOSs-/- and wild-type mice at 8-12 weeks of age (n=9-11). Cerebral infarct size was evaluated by ...
TY - JOUR. T1 - Decreases in Electrocardiographic R-Wave Amplitude and QT Interval Predict Myocardial Ischemic Infarction in Rhesus Monkeys with Left Anterior Descending Artery Ligation. AU - Sun, Xiaorong. AU - Cai, Jindan. AU - Fan, Xin. AU - Han, Pengfei. AU - Xie, Yuping. AU - Chen, Jianmin. AU - Xiao, Ying. AU - Kang, Yujian. PY - 2013/8/13. Y1 - 2013/8/13. N2 - Clinical studies have demonstrated the predictive values of changes in electrocardiographic (ECG) parameters for the preexisting myocardial ischemic infarction. However, a simple and early predictor for the subsequent development of myocardial infarction during the ischemic phase is of significant value for the identification of ischemic patients at high risk. The present study was undertaken by using non-human primate model of myocardial ischemic infarction to fulfill this gap. Twenty male Rhesus monkeys at age of 2-3 years old were subjected to left anterior descending artery ligation. This ligation was performed at varying ...
The territory of the middle cerebral artery is well illustrated with this complete MCA territory infarct. The frequently associated hyperdense artery sign indicative of intra-arterial clot is also evident.
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Diagnosis Code I63.39 information, including descriptions, synonyms, code edits, diagnostic related groups, ICD-9 conversion and references to the diseases index.
A registry of consecutive patients who were admitted and diagnosed with acute myocardial infarction or acute cerebral infarction were conducted at the Guangdong General Hospital or the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Yue Bei Peoples Hospital, China, between January 2000 and December 2016. The adverse clinical outcomes, including all-cause mortality, were followed from the date of admission for acute myocardial infarction or acute cerebral infarction until study end (December 31, 2016). All-cause mortality, including the date of death, was identified from the electronic hospitalization data, phone follow-up, and confirmed by the household registration (HUKOU) system, a record of registration required by law in China. Baseline characteristics, including major treatment of acute myocardial infarction or acute cerebral infarction, estimated glomerular filtration rate (eGFR) and proteinuria, were collected. Demographic data were determined from the electronic ...
In this study, we considered that patients with multiple recent subcortical (lacunar) infarcts seen on DWI would be likely to have a proximal embolic source, but were able to find a definite embolic source in only one patient. Thus, embolic mechanisms would not be a likely explanation for the occurrence of multiple acute lacunar infarcts in most of our patients. This is consistent with previous clinical and epidemiological studies (summarised by Mead et al7) which found that, while some lacunar strokes might be attributed to cardiac or artery-to-artery emboli, the majority (,80%) occurred in the absence of a definite embolic source.5,7,12 Few of our patients gave any history of previous stroke or TIA, and it was generally a long time before the current presentation, indicating that most of the acute as well as the old small subcortical lesions were asymptomatic.. Four of the 10 patients were not classified clinically as having a lacunar syndrome (two posterior circulation and two partial ...
Diagnosis Code I63.01 information, including descriptions, synonyms, code edits, diagnostic related groups, ICD-9 conversion and references to the diseases index.
Cerebrovascular Disease - abnormality of the brain resulting from pathological processes of the blood vessels any lesions of the vessel wall, occlusion of vessel lumen by an embolus or thrombosis, rupture of the vessel, altered permeability of the vessel wall or increased viscosity or other changes of the blood quality. Equally important are the metabolic and chemical changes that occur within the brain. Minor Traumatic Brain Injury , ischemic cerebral infarction ...
A cerebral infarction is an area of necrotic tissue in the brain resulting from a blockage or narrowing in the arteries supplying blood and oxygen to the brain. The restricted oxygen due to the restricted blood supply causes an ischemic stroke that can result in an infarction if the blood flow is not restored within a relatively short period of time. The blockage can be due to a thrombus, an embolus or an atheromatous stenosis of one or more arteries. Which arteries are problematic will determine which areas of the brain are affected (infarcted). These varying infarcts will produce different symptoms and outcomes. About one third will prove fatal. There are various classification systems for a cerebral infarction. The Oxford Community Stroke Project classification (OCSP, also known as the Bamford or Oxford classification) relies primarily on the initial symptoms. Based on the extent of the symptoms, the stroke episode is classified as total anterior circulation infarct (TACI), partial anterior ...
Our findings indicate that, in children with MCA territory infarcts, although the functional sequelae of small lesions might be variable, infarction of more than 10% ICV is associated with pronounced residual deficits.. There are methodological constraints inherent in measuring infarct volumes in the manner described here. The reproducibility of measuring individual volumes in the our study was compromised by subjectively defining the lesion boundaries, both in the acute and chronic stages. This was especially difficult in the case of small lesions, as is apparent from the data presented in table 2, where relatively small absolute differences in measurement resulted in large percentage differences in repeated measurements. In contrast, the reproducibility of the ICV measurements was good.. The natural history of cerebral infarction on MRI is for signal hyperintensity and swelling on T2 weighted images to be apparent around six to 12 hours after symptom onset.11 Chronic infarcts show signal ...
One-hundred patients had attempted endovascular treatment. At procedure end, 23% were thrombolysis in cerebral infarction 0-1, 31% thrombolysis in cerebral infarction 2A, 28% thrombolysis in cerebral infarction 2B, and 18% thrombolysis in cerebral infarction 3. More favorable thrombolysis in cerebral infarction-reperfusion scores were associated with greater magnetic resonance imaging reperfusion (P , 0·001). thrombolysis in cerebral infarction scores correlated with 30-day favorable clinical response (P = 0·041) and 90-day modified Rankin Scale 0-2 (P = 0·008). These correlations were significant for target mismatch patients at 30 days (P = 0·034) and 90 days (P = 0·003). Infarct growth was strongly associated with poorer thrombolysis in cerebral infarction scores in target mismatch patients (P , 0·001). Patients with thrombolysis in cerebral infarctionnfarction 2A reperfusion had less magnetic resonance imaging reperfusion (P = 0·004) and poorer clinical outcome at 90 days (P = 0·01) ...
Editor-Christopher J Weir and colleagues conclude from their study of a cohort of 750 non-diabetic patients with stroke that hyperglycaemia (plasma glucose concentration ,8 mmol/l) during the acute phase has an adverse influence on outcome and that this is independent of severity of stroke.1 Stroke severity was assessed in a limited way using only the Oxfordshire community stroke project classification and time to resolution of symptoms (≤72 hours or ,72 hours), both of which are relatively inaccurate measures. When two variables are closely correlated-for example, stroke severity and glucose concentration-the one that is most accurately measured (glucose concentration) will always emerge as the strongest explanatory variable in multiple regression even if it is, in fact, less important.2. We have produced a series of validated models to predict the probability of survival and disability using the 530 patients from the Oxfordshire community stroke project who were seen within 30 days of their ...
In last decade, similar to myocardial infarction treatment, thrombolytic drugs were introduced in the therapy of cerebral infarction. The use of intravenous rtPA therapy can be advocated in patients who arrive to stroke unit and can be fully evaluated within 3 h of the onset.. If cerebral infarction is caused by a thrombus occluding blood flow to an artery supplying the brain, definitive therapy is aimed at removing the blockage by breaking the clot down (thrombolysis), or by removing it mechanically (thrombectomy). The more rapidly blood flow is restored to the brain, the fewer brain cells die. In increasing numbers of primary stroke centers, pharmacologic thrombolysis with the drug tissue plasminogen activator (tPA), is used to dissolve the clot and unblock the artery. Another intervention for acute cerebral ischaemia is removal of the offending thrombus directly. This is accomplished by inserting a catheter into the femoral artery, directing it into the cerebral circulation, and deploying a ...
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TY - JOUR. T1 - Decreasing incidence of lacunar vs other types of cerebral infarction in a Japanese population. AU - Kubo, M.. AU - Kiyohara, Y.. AU - Ninomiya, T.. AU - Tanizaki, Y.. AU - Yonemoto, K.. AU - Doi, Y.. AU - Hata, J.. AU - Oishi, Y.. AU - Shikata, K.. AU - Iida, M.. PY - 2006/5/1. Y1 - 2006/5/1. N2 - BACKGROUND: There is scant information on secular trends in the incidence and survival of ischemic stroke subtypes. METHODS: The authors established three cohorts of Hisayama residents age ≥40 years in 1961 (1,618 subjects), 1974 (2,038 subjects), and 1988 (2,637 subjects). They followed up with each cohort for 12 years, comparing the incidence and survival rate of ischemic stroke subtypes. Morphologic examinations by autopsy or brain imaging was performed on most of the ischemic stroke cases in all cohorts. RESULTS: The age-standardized incidence of lacunar infarction significantly declined by 59% for men and by 28% for women from the first to the second cohort. It continued to ...
Translocator protein (TSPO) imaging can be used to detect neuroinflammation (including microglial activation) after acute cerebral infarction. However, longitudinal changes of TSPO binding after mild ischemia that induces selective neuronal loss (SNL) without acute infarction are not well understood. Here, we performed TSPO imaging with [18F]DPA-714 to determine the time course of neuroinflammation and SNL after mild focal ischemia. Mild focal ischemia was induced by middle cerebral artery occlusion (MCAO) for 20 min. In MCAO rats without acute infarction investigated by 2, 3, 5-triphenyltetrazolium chloride (TTC) staining, in vitro ARG revealed a significant increase of [18F]DPA-714 binding in the ipsilateral striatum compared with that in the contralateral side at 1, 2, 3, and 7 days after MCAO. Increased [18F]DPA-714 binding was observed in the cerebral cortex penumbra, reaching maximal values at 7 days after MCAO. Activation of striatal microglia and astrocytes was observed with immunohistochemistry
This is a first-in-human (FIH) study of 42037788 (referred to as CNTO 0007), a cell therapy being tested to see if it may be useful in treating patients with ischemic cerebral infarction also known as stroke. Patients will be randomized (assigned by chance) to receive a single dose of CNTO 0007 or placebo (identical in appearance to CNTO 0007 but does not contain cells) by intravenous (IV) infusion (injection directly into a vein). Patients and study staff will not know if patients are assigned CNTO 0007 or the placebo. The study will be conducted in 2 stages (Stage A and Stage B). In Stage A, the highest dose of CNTO 0007 that does not cause unacceptable side effects, referred to as the maximum tolerated dose (MTD) will be determined to and administered to patients in Stage B of the study. In Stage A, 5 (up to 7) cohorts (groups) of 4-8 patients each will be administered a single IV infusion of CNTO 0007 or placebo 1-5 days (depending on cohort) after stroke (the first cohort of patients will ...
A 64-year-old man visited our hospital with a chief complaint of appetite loss and epigastralgia. Upper GI series and an endoscopic examination revealed type 3 carcinoma on the upper third. Abdominal CT scan showed enlargement of the paraaortic lymph nodes that had invaded the pancreas. Preoperative diagnosis was cStage Ⅳ gastric cancer, and we considered a curative operation impossible. Therefore, chemotherapy with a combination therapy of 5-fluorouracil (5-FU) and low-dose cisplatin (CDDP) was planned. After 19 days of administration, the patient without vascular risk factors suddenly exhibited diplopia and left-member weakness. Brain CT showed a low- density area at the occipital lobe. Though we diagnosed cerebral infarction and treated with anti-thrombus therapy, he died of multiple cerebral infarction on day 12 of the treatrnent ...
The thrombolysis in cerebral infarction (TICI) grading system was described in 2003 by Higashida et al. 1 as a tool for determining the response of thrombolytic therapy for ischaemic stroke. In neurointerventional radiology it is commonly used fo...
Cerebral infarction is the most common form of stroke (80% of strokes). Stroke is the first cause of acquired disability, and the 2nd cause of dementia and death. The only approved treatment in the first 4.5 hour is intravenous rt-PA thrombolysis (Actilyse ®) whose objective is recanalization of occluded artery and reperfusion of the brain parenchyma. Few patients are treated (1-5%) and they keep disability in 50-60% of cases. This handicap is mainly correlated to the final infarct size. The objective of neuroprotective treatments is to reduce the final size of the cerebral infarction. The per-conditioning remote ischemic (Per-CID) showed a neuroprotective effect in cerebral ischemia by reducing the final size of cerebral infarction animal models. The per-CID corresponds, in cases of cerebral ischemia, to iterative ischemia realization of a member with a cuff. In humans, the per-CID has shown a cardioprotective effect in a randomized control trial involving 250 patients within 6 first hours of ...
Background: It has been suggested that iron metabolism may be involvedin the pathogenesis of atherothrombotic cerebral infarction (ACI). The C282Y and H63D mutations in thehemochromatosis (HFE) gene are associated with increased serum iron levels and net iron accumulation.The aim of this study was to test the hypothesis that the C282Y and H63D mutations in the HFE gene arerisk factors for ACI in a Slovene population. Material/Methods: The C282Y and H63D HFE gene mutationswere tested in 96 Caucasian patients who had suffered an acute cerebral infarction, later confirmed asACI, and 115 control subjects. Genotypes were determined by electrophoresis of the DNA digestion productsfrom RsaI (C282Y) and MboI (H63D). Results: We failed to demonstrate that the C282Y and H63D mutationswere risk factors for ACI in Caucasians. The percentage of C282Y and H63D genotypes (dominant model)in ACI-cases (C282Y: 7.3%, n=7; H63D: 28.1%, n=27) did not differ significantly (P=0.9 and P=0.7 respectively)from that of ...
The frequencies of all adverse events observed during the observation period will be tabulated by symptom, type, and seriousness. In addition, the frequency of recurrence of cerebral infarction will be tabulated by time from first onset of cerebral infarction, risk factors for cerebral infarction, concomitant antihypertensive medications (if any), and concomitant antiplatelet/anticoagulant medications (if any).. Adverse events are defined as any unfavorable and unintended signs, symptoms or diseases temporally associated with administration of pioglitazone whether or not it was considered related to treatment. Among these, events that are considered as having a causal relationship with pioglitazone are defined as adverse drug reactions. ...
The intraluminal middle cerebral occlusion model in mice is herein presented. The extent of cerebral infarct is evaluated by a...
The interest in calculating acute infarct mass following occlusion of a coronary artery originates mainly from two sources: 1. Acute infarct mass is related not only to the short-term (hospital)...
2. CT-scan is positive in most cases of cerebral infarction (decreased density), but peruhahan these changes can only be seen in 24-48 hours after the onset of stroke symptoms. By penyengatan of contrast, infarct can mimic a tumor but penyengatan against the contrast of the cerebral infarction is generally not associated with significant mass effect as happened in tumors. In a few instances. maybe there is mass effect with infarction, which raises the question of whether not a tumor, in which case it is with MRI, CT scan and serial clinical observations may clarify the diagnosis. ...
Our phase I study is the first trial to use mature DCs pulsed with a mixture of three types of WT1 peptides restricted by MHC-I/II into one site in combination with chemotherapy.. The safety profile constituted the primary end point. One patient PDA-06 with multiple liver metastases showed rapid disease progression and died of a cerebral infarction. DTH to the WT1-I/II peptides was negative during all vaccination periods. Cerebral infarction, reported here as a severe adverse event, could be caused by the pancreatic cancer itself and/or the administration of gemcitabine, both of which are associated with a high risk of developing thrombotic disease (23). In particular, patients with PDA with metastatic disease are at the highest risk for cancer-associated thromboembolic stroke (24). The supervising Data Safety and Monitoring Board (DSMB) determined that the patient died of stroke induced by a cancer-related hypercoagulable state. Finally, the DSMB determined that the case was not related to the ...
Multiplanar magnetic resonance (MR) images of 77 discrete infarcts in the basal grey matter region from 71 patients were reviewed for their distribution and extent, in correlation with the...
Nimodipine is a 1,4-dihydropyridine derivative that shows a preferential cerebrovascular activity in experimental animals. Clinical data suggest that nimodipine has a beneficial effect on the neurologic outcome of patients suffering an acute ischemic stroke. Our double-blind placebo-controlled multi...
Looking for hemorrhagic infarct? Find out information about hemorrhagic infarct. Localized death of tissue that is caused by obstructed inflow of arterial blood. Also known as infarction. a focus of organ or tissue necrosis resulting... Explanation of hemorrhagic infarct
Large hemispheric infarction (LHI) is a severe form of stroke with high mortality and disability rates. The purpose of this study was to explore predictive indicators of the in-hospital mortality of LHI patients treated conservatively without decompressive hemicraniectomy. We performed a retrospective study of 187 consecutive patients with LHI between January 1, 2016 to May 31, 2019. The receiver operating curves were preformed to evaluate predictive performance of demographics factors, biomarkers and radiologic characteristics. Significant prognostic factors were combined to build a nomogram to predict the risk of in-hospital death of individual patients. One hundred fifty-eight patients with LHI were finally enrolled, 58 of which died. Through multivariate logistic regression analysis, we identified that independent prognostic factors for in-hospital death were age (adjusted odds ratio [aOR] = 1.066; 95% confidence interval [CI], 1.025-1.108; P = 0.001), midline shift (MLS, aOR = 1.330, 95% CI, 1.177
TY - JOUR. T1 - Shift of motor activation areas during recovery from hemiparesis after cerebral infarction. T2 - A longitudinal study with near-infrared spectroscopy. AU - Takeda, Kotaro. AU - Gomi, Yukihiro. AU - Imai, Itsuki. AU - Shimoda, Nobuaki. AU - Hiwatari, Masao. AU - Kato, Hiroyuki. PY - 2007/10/1. Y1 - 2007/10/1. N2 - Motor functional recovery after stroke may be attributable to cerebral reorganization. We used near-infrared spectroscopy, which measures non-invasively the changes in oxy- and deoxy-hemoglobin concentrations in response to neural activation, for monitoring cerebral activation in stroke patients, and investigated the longitudinal changes in functional laterality of activations in the primary sensorimotor cortex during unilateral audio-paced (1 Hz) hand movement. We examined five ischemic stroke patients (4 females and 1 male, 52-67 years old) with mild to moderate hemiparesis at acute stages and chronic stages at least 1 month later. Normal subjects (3 females and 2 ...
TY - JOUR. T1 - Juvenile-onset multiple brain infarcts localized in the posterior circulation. T2 - A case report. AU - Maruyama, Kenji. AU - Oya, Yasushi. AU - Shigeto, Hiroshi. AU - Ogawa, Masafumi. AU - Kawai, Mitsuru. PY - 2002/3/14. Y1 - 2002/3/14. N2 - We report a 37-year-old male patient with multiple brain infarcts due to arterial lesions localized in the posterior circulation, who developed a paramedian pontine infarct on the left side. He had been treated as schizophrenia for 20 years. A cranial CT performed one year before showed old small infarcts in the territories of the bilateral thalamo-perforating and left thalamo-geniculate arteries and the right posterior inferior cerebellar artery. The vertebral and basilar arteries were small in diameter on MRI and MR angiography (MRA). Cerebral angiography revealed a narrow smooth basilar artery. In addition, the P 2 segments of the bilateral posterior cerebral arteries were markedly narrow with irregular walls. Carotid arteriograms were ...
ObjectiveTo describe a patient who developed reversible segmental cerebral arterial vasospasm and cerebral infarction while taking excessive amounts of sumatrip
Detection of misery perfusion in the cerebral hemisphere with chronic unilateral major cerebral artery steno-occlusive disease using crossed cerebellar hypoperfusion: comparison of brain SPECT and PET imaging. Matsumoto, Yoshiyasu; Ogasawara, Kuniaki; Saito, Hideo; Terasaki, Kazunori; Takahashi, Yoshihiro; Ogasawara, Yasushi; Kobayashi, Masakazu; Yoshida, Kenji; Beppu, Takaaki; Kubo, Yoshitaka; Fujiwara, Shunrou; Tsushima, Eiki; Ogawa, Akira // European Journal of Nuclear Medicine & Molecular Imaging;Oct2013, Vol. 40 Issue 10, p1573 Purpose: In patients with unilateral internal carotid or middle cerebral artery (ICA or MCA) occlusive disease, the degree of crossed cerebellar hypoperfusion that is evident within a few months after the onset of stroke may reflect cerebral metabolic rate of oxygen in the affected cerebral... ...
The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction ...
Recommendations from experts and recently established guidelines on how to improve the face and predictive validity of animal models of stroke have stressed the importance of using older animals and long-term behavioral-functional endpoints rather than relying almost exclusively on acute measures of infarct volume in young animals. The objective of the present study was to determine whether we could produce occlusions in older rats with an acceptable mortality rate and then detect reliable, long-lasting functional deficits. A reversible intraluminar suture middle cerebral artery occlusion (MCAO) procedure was used to produce small infarcts in middle-aged rats. This resulted in an acceptable mortality rate, and robust disabilities were detected in functional assays, although the degree of total tissue loss measured 90 d after MCAO was quite modest. Infarcted animals were functionally impaired relative to sham control animals even 90 d after the occlusions, and when animals were subgrouped based ...
Silent brain infarction is a frequent complication of cardiac surgery and is associated with mood changes and cognitive disruption. Microsphere embolism (ME) rodent models recapitulate both the diffuse ischemic infarcts and the delayed subtle behavioral disturbances characteristic to silent infarction (SI). Previously, we have shown that ME leads to increased hippocampal inflammation, weakening of the blood brain barrier, and the infiltration of peripherally circulating inflammatory cells in rats. Given long-term increases in inflammatory activity following SI, the current study tests the efficacy of anti-inflammatory versus anti-depressant treatment strategies to reduce the inflammatory and behavioral sequelae of injury. Adult rats were administered either chronic meloxicam (preferential COX-2 inhibitor) or fluoxetine (SSRI) beginning five days prior to ME surgeries. After a two week recovery, animals were tested for anxiety-like behaviors in the open field paradigm and the hippocampus was ...
TY - JOUR. T1 - Establishing final infarct volume. T2 - Stroke lesion evolution past 30 days is insignificant. AU - Gaudinski, Martin R.. AU - Henning, Erica C.. AU - Miracle, Aaron. AU - Luby, Marie. AU - Warach, Steven. AU - Latour, Lawrence L.. PY - 2008/10/1. Y1 - 2008/10/1. N2 - Background and Purpose: Lesion volume measured on MRI has been used as an objective surrogate marker for outcome in clinical trials. However, lesion volumes vary over time because of edema and tissue loss. This study aims to determine if lesion volumes measured at 30 and 90 days after ictus significantly differ. Methods: We performed a retrospective study of 18 patients who had acute (,24 hours) DWI and follow-up fluid-attenuated inversion recovery imaging at 5, 30, and 90 days. Two expert readers segmented lesions and the mean volumes of both reads were used in all statistical analyses. Results: Patient age was 65.8 (SD, 13.7) years and median NIHSS at baseline was 11.5. Inter-rater variability for lesion volume ...