Radiation therapy can cause cerebral arteriopahty, resulting in ischemic stroke. We document late-delayed cerebral arteriopathy by high-resolution magnetic resonance imaging (HR-MRI) in a middle aged man who had cranial irradiation 19 years earlier. A 45-year-old man was diagnosed with frontal lobe glioma 19 years ago and was treated with radiation after surgical resection. He was admitted to our hospital with an acute cerebral infarction in November 8, 2017. Traditional MRI examination and HR-MRI (sagittal, reconstruction of coronal and axial) were performed at admission. He was treated with prednisone (30 mg/day) and clinical symptoms disappeared after 3 months by telephone follow-up. Our patient complained of dizziness and blurred vision and traditional MRI examination indicated acute ischemic stroke in temporal lobe and occipital lobe and microbleeds. In order to define the exact mechanism of stroke, blood tests, auto-immune screening and thrombophilia were performed and results were normal.
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The instability of carotid and coronary plaques has been reported to be associated with acute coronary syndrome, strokes and other cerebrovascular events. Therefore, recognition of the tissue characteristics of carotid and coronary plaques is important to understand and prevent coronary and cerebral artery disease. Recently, an ultrasound integrated backscatter (IB) technique has been developed. The ultrasound IB power ratio is a function of the difference in acoustic characteristic impedance between the medium and target tissue, and the acoustic characteristic impedance is determined by the density of tissue multiplied by the speed of sound. This concept allows for tissue characterization of carotid and coronary plaques for risk stratification of patients with coronary and cerebral artery disease. Two- and three-dimensional IB color-coded maps for the evaluation of tissue components consist of four major components: fibrous, dense fibrosis, lipid pool and calcification. Although several ultrasound
ChILD: A Pictorial Review of Pulmonary Imaging Findings in Childhood Interstitial Lung Diseases. Verma N, Altmayer S, Hochhegger B, Barros MC, Rajderkar D, Mohammed TL. Curr Probl Diagn Radiol. 2020 April. PMID: 32317133 Dilated Cerebral Arteriopathy in Classical Pompe Disease: A Novel Finding. Viamonte M, Tuna I, Rees J. Pediatr Neurol. 2020 March. PMID: 32248988…
Metabolomics is a large-scale approach to monitoring as many as possible of the compounds involved in cellular processes in a single assay to derive metabolic profiles. Compared with genomics or proteomics, metabolomics reflects changes in phenotype and therefore function. Collection of exhaled breath condensate (EBC) is a newly developed, noninvasive method that may allow clinicians and researchers to assess biochemical profiles in the alveolar lining fluid. The aims of this study are: (1)Collecting and metabolomic profiling of the EBCs from patients with COPD/bronchiectasis; (2) Comparing the profiles of these patients obtained during stable and acute exacerbation periods; (3) Comparing the profiles of these patients with and without Pseudomonas colonization/infection; (4) Correlation of EBC metabolomic profiles with clinical phenotypes, severity and outcomes of these patients ...
This is the first case report of a CADASIL patient with MCA stenosis who underwent STA-MCA bypass to increase cerebral perfusion in the localized ischemic area. In CADASIL, reductions in both CBF and CVR occur in white matter showing T2-hyperintensity. It has been suggested that the degeneration of vascular smooth muscle cells causes arteriopathy, which leads to cerebral hypoperfusion and impaired autoregulation (Chabriat et al. 2000; Huang et al. 2010; Singhal and Markus 2005; van den Boom et al. 2003). Interestingly, the white-matter hyperintensity in the temporal lobe was found predominant in the left side in this case. This asymmetry of white-matter hyperintensity is very unusual rare in CADASIL, since it would suggest that these lesions do not originate from ischemia, but edema instead. The lower extent observed in the most hypoperfused temporal lobe further support that these lesions are not related to ischemia but mat actually result from edema with blood brain barrier dysfunction. ...
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TY - JOUR. T1 - Sex-Dependent Differences in Physical Exercise-Mediated Cognitive Recovery Following Middle Cerebral Artery Occlusion in Aged Rats. AU - Cohan, Charles H.. AU - Youbi, Mehdi. AU - Saul, Isabel. AU - Ruiz, Alex A.. AU - Furones, Concepcion C.. AU - Patel, Pujan. AU - Perez, Edwin. AU - Raval, Ami P.. AU - Dave, Kunjan R.. AU - Zhao, Weizhao. AU - Dong, Chuanhui. AU - Rundek, Tatjana. AU - Koch, Sebastian. AU - Sacco, Ralph L.. AU - Perez-Pinzon, Miguel A.. PY - 2019/9/18. Y1 - 2019/9/18. N2 - Stroke remains a leading cause of death and disability in the United States. No current treatments exist to promote cognitive recovery in survivors of stroke. A previous study from our laboratory determined that an acute bout of forced treadmill exercise was able to promote cognitive recovery in 3 month old male rats after middle cerebral artery occlusion (MCAo). In this study, we tested the hypothesis that 6 days of intense acute bout of forced treadmill exercise (physical exercise - PE) ...
Authors: Allen, Rachael S. , Sayeed, Iqbal , Oumarbaeva, Yuliya , Morrison, Katherine C. , Choi, Paul H. , Pardue, Machelle T. , Stein, Donald G. Article Type: Research Article Abstract: Background/Objective: To determine whether inflammation increases in retina as it does in brain following middle cerebral artery occlusion (MCAO), and whether the neurosteroid progesterone, shown to have protective effects in both retina and brain after MCAO, reduces inflammation in retina as well as brain. Methods: MCAO rats treated systemically with progesterone or vehicle were compared with shams. Protein levels of cytosolic NF-κ B, nuclear NF-κ B, phosphorylated NF-κ B, IL-6, TNF-α, CD11b, progesterone receptor A and B, and pregnane X receptor were assessed in retinas and brains at 24 and 48 h using western blots. Results: …Following MCAO, significant increases were observed in the following inflammatory markers: pNF-κ B and CD11b at 24 h in both brain and retina, nuclear NF-κ B at 24 h in brain and ...
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Стиль: Brutal Death Группа: Reincarnation Видео: The Streets Never Sleep (Клип) Альбом: The Beginning Of The End (2015) Год: 2015 С ...
Duckcore is the first with this EP. For an unknown band these guys make some pretty mean deathcore. Definitely worth a listen to ...
Reversible cerebral vasoconstriction syndrome (RCVS) is a fairly recently described constellation of clinical and radiological features: sudden, severe ("thunderclap") headache; transient, multifocal, segmental vasoconstriction of cerebral arteries lasting several weeks to months; and focal neurological symptoms, sometimes with stroke. The features of what is now called RCVS have been repeatedly recognized, especially since an influential early report by Drs Call and Fleming et al1 published in 1988. A similar syndrome has attracted many different names, depending on whether patients present to specialists in headache, obstetrics, or neurology. These include thunderclap headache with vasospasm, migrainous vasospasm (or "crash" migraine), migrainous angiitis, drug-induced angiitis, postpartum angiopathy, and benign angiopathy of the central nervous system. The label RCVS is an attempt to unify these various descriptions of a distinct clinico-radiological pattern. Nevertheless, there remains ...
BACKGROUND AND AIM OF THE STUDY: Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by severe thunderclap headache, with or without associated neurological symptoms and neuroimaging findings of reversible vasoconstriction of cerebral arteries. Puerperium is a recognized precipitant, but the incidence of puerperal RCVS is unknown. We conducted a prospective study to assess incidence, risk factors and clinical features of RCVS. MATERIAL AND METHOD: Nine-hundred consecutive puerperae were prospectively enrolled within three days of delivery. Past medical history, basal demographic, anthropometric and biological variables were recorded. Transcranial Colour Coded Sonography (TCCS) was performed to assess early signs of vasospasm in brain vessels. A structured telephone interview was planned in all subjects one month postdelivery. RESULTS: Thunderclap headache was recorded in 8 subjects (0.9%) on the first visit. At the one month follow-up interview 27 more patients reported having had at
Reversible cerebral vasoconstriction syndrome (RCVS) is a group of conditions with a common clinical and radiologic presentation. It is characterized by thunderclap headache and reversible vasoconstriction of the cerebral arteries. Terminology ...
Reversible cerebral vasoconstriction syndrome (RCVS, sometimes called Call-Fleming syndrome) is a disease characterized by a weeks-long course of thunderclap headaches, sometimes focal neurologic signs, and occasionally seizures. Symptoms are thought to arise from transient abnormalities in the blood vessels of the brain. In some cases, it may be associated with childbirth, vasoactive or illicit drug use, or complications of pregnancy. For the vast majority of patients, all symptoms disappear on their own within three weeks. Deficits persist in a small minority of patients, with severe complications or death being very rare. Because symptoms resemble a variety of life-threatening conditions, differential diagnosis is necessary. The key symptom of RCVS is recurrent thunderclap headaches, which over 95% of patients experience. In two-thirds of cases, it is the only symptom. These headaches are typically bilateral, very severe and peak in intensity within a minute. They may last from minutes to ...
ObjectivesTo further improve the distinction between primary angiitis of the CNS (PACNS) and reversible cerebral vasoconstriction syndrome (RCVS).MethodsWe compared 2 large French cohorts of patients with PACNS (n = 110, retrospectively and prospectively enrolled) and RCVS (n = 173, prospectively en
Details of the image Reversible cerebral vasoconstriction syndrome (RCVS) with associated convexity subarachnoid haemorrhage, nimodipine-reversibility Modality: DSA (angiography) (External carotid artery)
1) Influence of sodium consumption and associated knowledge on post-stroke hypertension in Uganda 2) e-Pearl topic: Transient cerebral arteriopathy 3) Topic of the month: Neurologic prognosis following cardiac arrest This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Justin Sattin interviews Dr. Larry Goldstein about his paper on the influence of sodium consumption and its associated knowledge on post-stroke patients with and without a history of hypertension in Uganda. Dr. Adam Num Read More 1) Influence of sodium consumption and associated knowledge on post-stroke hypertension in Uganda 2) e-Pearl topic: Transient cerebral arteriopathy 3) Topic of the month: Neurologic prognosis following cardiac arrest This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the ...
RCVS is a cerebrovascular disorder that can be occur as late as 3 weeks after an uncomplicated pregnancy, characteristic neuroimaging finding accompanied by severe and acute headache are important key features to consider RCVS diagnosis.. Here were present a 39-year-old woman, presented with headache and subsequent right hemiparesis 3 weeks after abortion. First brain CT scan was unremarkable. Brain CT angiography showed multiple segmental stenosis and at later scans, she developed sub arachnid hemorrhage (SAH) which is a pathognomonic feature of RCVS. She was treated with calcium channel blocker and headache relieved and hemiparesis was improved. Final diagnosis was made based on normal trans-cranial Doppler (TCD) study after 4 weeks of symptoms onset.. ...
Background and purpose: Atherosclerotic stenosis of major intracranial arteries accounts for 5 to 10% of all causes of stroke. The Warfarin versus Aspirin Symptomatic Intracranial Disease (WASID) Study has demonstrated stroke onset in 5 among 100 patients with asymptomatic intracranial arterial stenosis (AIAS) during the follow-up period of 1.8 years. However, there are no prospective studies of intracranial stenosis in healthy subjects with a longer follow-up period. We conducted a 7-years longitudinal study in healthy subjects with AIAS to examine its risk factors and prognosis.. Methods: We performed a prospective study on 3,155 neurologically normal subjects without history of stroke (1724 men, 1431 woman, mean age of 59). They were followed up with the mean interval of 83 months to obtain information about their stroke event with a questionnaire by mail or telephone interview and inquiry to the relevant medical facilities. AIAS were assessed on MRA at the time of first visit for all ...
Cerebral Vasculitis Definition Vasculitis a condition is characterized by inflammation of the blood vessel walls. Cerebral Vasculitis is one form of this disease that involves the CNS. It usually involves the brain and at times, the spinal cord. Sometimes, the word Vasculitis in the name of the condition is replaced
migraine with aura cerebral infarction and dementia other cerebral vascular disorders in particular cerebral venous thrombosis reversible cerebral vasoconstriction syndrome and cervical artery dissection the genetics and treatment of migraine Jean Pierre Kahane Professor Emeritus Paris Sud University Member of the Académie des sciences Xavier Lacroix Professor Emeritus Lyon Catholic University former Director of the Institut des sciences de la famille de Lyon former Dean of the Theology Faculty of Lyon member of the Academic Corpus of the Académie catholique de France Xavier VANDENDRIESSCHE Professor of Law President Lille 2 Law and Health University Francis Puech Gynaecologist Obstetrician Professor Emeritus President of the Collège National des Gynécologues et Obstétriciens Français National College of French Gynaecologists and Obstetricians President of the Commission Nationale de la Naissance et de la Santé de l Enfant DGS DGOS National Commission on Childbirth and Children s Health ...
Specific patterns of white matter hyperintensities in the brain may guide diagnosis of reversible cerebral vasoconstriction syndrome, a disorder predominantly characterized by severe thunderclap headaches.
This study will recruit 480 acute stroke patients with symptomatic intracranial stenosis (M1 segment of Middle cerebral artery (MCA) or basilar artery).. They will be randomly assigned into cilostazol group or clopidogrel group. Every patients will take 100mg of aspirin a day additionally.. The primary outcome variable of this study is Progression rate of symptomatic intracranial stenosis on magnetic resonance angiogram (MRA). ...
Strong correlations between plasma lipoprotein concentrations and the risk of stroke have never been clearly established. Unlike coronary heart disease, there is no significant direct relation between an increased risk of stroke and increased plasma total cholesterol or low density lipoprotein (LDL) cholesterol; nor is there an inverse relation with high density lipoprotein (HDL) cholesterol.1 Indeed, an inverse relation exists between total cholesterol concentrations and cerebral haemorrhage.2. The reasons for this weak or absent relation are several. The most compelling is that virtually all coronary heart disease can be ascribed to coronary atheroma, whereas less than half the incidence of stroke is due to large vessel atheroma. Non-atheromatous causes such as cardiac arrhythmias, small cerebral artery disease, and cortical degeneration are responsible for most of the rest. Another is that, in general, coronary deaths occur at a younger age than strokes, so the population with raised plasma ...
The importance of recognizing and proactively managing impaired swallowing should not be underestimated. Dysphagia is seen in 42-67% of patients within the first 72 hours post stroke.{ref5} Per stroke... more
Finally it was time for the headliners, Misery Index. Their muscle bound drummer to his kit and did a bit or warming up as the settings were perfected on his drum triggers. His kick drums sounded great. The band had played an all ages show the night before and they commented on how they were surprised that so many people turned up on the second night to see them. I didn?t go to the all ages show since I feel like some dirty old man when hanging around with a load of 15 year olds. Those shows should not be called ?all ages? but more like ?teens only? since anyone over 19 stands out. Anyway, back to the bar show. As mentioned earlier, I was not expecting a whole lot from the band, and it turns out that was a good thing because as soon as they started playing I looked at Rick with a grin and we both realized we were in for a treat. In the live situation the band didn?t sound like noise, or like grind-core. They played brutal death metal, and they played it tight. The bands riffing chops are killer. ...
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Ashley EilandCMS 205.___ October 17, 2013 Title: The effects of Human Trafficking INTRODUCTION Attention-Getter -The unjustified trade and enslavement of...
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Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leucoencephalopathy (CADASIL), familial vascular leukoencephalopathy. Cerebral Autosomal Dominant Arteriopathy
If patients could recognise themselves, or anyone else could recognise a patient from your description, please obtain the patients written consent to publication and send them to the editorial office before submitting your response [Patient consent forms] ...
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Details of the image Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) Modality: MRI (T2)
Details of the image Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) Modality: MRI (Ax T2 C2-T1)
© Cambridge University Press 2014. Introduction: Cerebral ischemia is thought to be an important disease mechanism in cerebral small vessel disease (SVD). It has been hypothesized that acute ischemia in the territory of the perforating artery results in lacunar stroke, while chronic ischemia occurring in the distal territories of the perforating arteries results in changes to cerebral white-matter, known as leukoaraiosis. The spatial pattern of leukoaraiosis, with changes first occurring in the brain regions furthest from the origin of the perforating arteries, would be consistent with disease occurring due to hypoperfusion. This has led to the suggestion that cerebral blood flow (CBF) is reduced in SVD, and many studies have been performed to investigate this issue. In addition, cerebral arteriopathy underlying SVD may also impair the ability of small cerebral vessels to vasodilate, leading to problems maintaining perfusion in response to drops in blood pressure and perfusion pressure. Impairments of
The purpose of the study was to highlight the acute motor reflex adaptation and to deepen functional deficits following a middle cerebral artery occlusion-reperfusion (MCAO-r). Thirty-six Sprague-Dawley rats were included in this study. The middle cerebral artery occlusion (MCAO; 120 min) was performed on 16 rats studied at 1 and 7 days, respectively (MCAO-D1 and MCAO-D7, n = 8 for each group). The other animals were divided into 3 groups: SHAM-D1 (n = 6), SHAM-D7 (n = 6) and Control (n = 8). Rats performed 4 behavioral tests (the elevated body swing test, the beam balance test, the ladder-climbing test and the forelimb grip force) before the surgery and daily after MCAO-r. H-reflex on triceps brachii was measured before and after isometric exercise. Infarction size and cerebral edema were respectively assessed by histological (Cresyl violet) and MRI measurements at the same time points than H-reflex recordings. Animals with cerebral ischemia showed persistent functional deficits during the ...
Reversible Cerebral Vasoconstriction Syndromes (RCVS) comprises a group of diverse conditions, all characterized by spasm of the brain vessels. The main symptom of RCVS is sudden, severe headaches. Strokes or bleeding into the brain may or may not be present. RCVS was previously named benign angiopathy of the central nervous system (BACNS) but the term was recently changed to include other similar disorders.. RCVS is a major mimic of central nervous system vasculitis and should be distinguished from it given the difference in the treatment and the outlook between the two disorders.. Abnormality in the control of brain blood vessel pressure is believed to be the critical element in the pathophysiology of RCVS. The alteration in vascular tone may be spontaneous or evoked by various exogenous or endogenous factors. There is no evidence of vasculitic changes in the brain tissue in RCVS.. It is essential for clinicians evaluating patients for CNS vasculitis to be aware of RCVS and to distinguish it ...
BACKGROUND AND PURPOSE: Elevated OEF is a surrogate for misery perfusion. Our aim was to detect misery perfusion in patients with unilateral steno-occlusive disease of the ICA or MCA by using T2*-based MR imaging and to determine the relationship between brain ischemia and OEF.. MATERIALS AND METHODS: Twenty-three patients with unilateral steno-occlusive disease of the ICA or MCA and 8 healthy volunteers were included in this study. Hemodynamic information was obtained in all subjects by MR imaging. Three regions of interest were placed in the anterior, middle, and posterior parts of the brain bilaterally to measure the OEF and CBF values, The OEFs of the regions of interest in the hemispheres ipsilateral and contralateral to the vascular lesions were compared. Brain regions with OEF greater than that in controls were determined as misery perfusion in patients. The association of vascular lesions, rCBF, and the presence of territory infarction with elevated OEF was investigated.. RESULTS: There ...
Female gender, which is abolished following ovariectomy and reproductive senescence, is associated with improved outcome following cerebral stroke. Estrogen replacement partially restores this benefit of the female gender but the effect of progesterone in hormone-deficient animals is currently unknown. We evaluated various outcomes following middle cerebral artery occlusion (MCAO) in ovariectomised female mice, with a physiologically relevant restoration of progesterone levels. Ovariectomised female mice had significantly elevated plasma (P=,0.05) and brain progesterone levels (P=,0.01) following implantation of a 21-day release pellet (50mg) compared with mice that received placebo implants 7 days prior to undergoing 60 min MCAO. Assessment of well-being (body weight recovery) and neurological score at 24h and 48h post-MCAO indicated that MCAO significantly worsened outcome compared with sham-operated mice but progesterone had no effect. MCAO resulted in a substantial lesion formation and a ...
When blood flow to part of the brain is blocked or reduced, the brain tissue is impacted and brain cells begin to die. This is known as a stroke. When an infant or child under the age of 18 has a stroke, it is known as a pediatric stroke.
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Rory McIlroy, armed with advice from Australian Greg Norman, returns to the scene of his first PGA Tour title looking to regain his stride after a stunning blowup at last month`s Masters.
I POAS this morning 2days before af is due, just to put myself out of my misery, it was a very faint BFP!!! trying no to get excited but when i have tested before have had nothing in that window!! keeping legs crossed until 2moro so i can test again, how hard will that be, am so shocked cos was convinced otherwise!!!good luck to everyone!!x ...
BRAIN ischemia stroke is a devastating disease, with more than 10% stroke patients either severely disabled or dead. Although rodent fil- ament middle cerebral artery occlusion (MCAO) model can mimic human brain ischemic stroke well, its wide use was
Electron microscopy of the skin biopsy showed proliferation of vascular smooth-muscle cells, crenation of the internal elastic lamina and fragmentation of elastic fibres. The basement membrane was irregular and osmiophilic granules were observed.. Neurophysiological examination showed normal visual, auditory and somatosensory evoked potentials, while the EEG revealed a single focal burst of sharp transients left mid-temporally; the alpha rhythm showed lower voltage on the left side.. Case 5. A 67-year-old white woman presented with memory problems and behavioural disturbances. The short-term memory loss had commenced 3 years previously; the behavioural disturbances were more recent, involving paranoid delusions, inappropriate behaviour and an obsession with sweets and diet pills. Episodes of confusion and a gait disturbance involving stiffness of the right leg had been noticed. Previously, the patient had suffered from migraine and had been treated for depression. She did not smoke. At least 2 ...
Cerebral vasculitis or central nervous system vasculitis (sometimes the word angiitis is used instead of "vasculitis") is vasculitis (inflammation of the blood vessel wall) involving the brain and occasionally the spinal cord. It affects all of the vessels: very small blood vessels (capillaries), medium-size blood vessels (arterioles and venules), or large blood vessels (arteries and veins). If blood flow in a vessel with vasculitis is reduced or stopped, the parts of the body that receive blood from that vessel begins to die. It may produce a wide range of neurological symptoms, such as headache, skin rashes, feeling very tired, joint pains, difficulty moving or coordinating part of the body, changes in sensation, and alterations in perception, thought or behavior, as well as the phenomena of a mass lesion in the brain leading to coma and herniation. Some of its signs and symptoms may resemble multiple sclerosis. 10% have associated bleeding in the brain. "Primary" Central Nervous System (CNS) ...