OBJECTIVE: Central sensitization is present in different pain conditions, including chronic whiplash-associated disorders. In the absence of a gold standard method of assessment to determine the presence of central sensitization, quantitative sensory testing is currently understood as an optimal proxy. Laboratory sensory testing is, however, not feasible in clinical practice, and the Central Sensitization Inventory was developed as an alternative. The aim of the current study was to evaluate the convergent validity of the Central Sensitization Inventory in chronic whiplash-associated patients by determining the association between the Central Sensitization Inventory and quantitative sensory testing, pain intensity, fatigue, and psychosocial factors. METHODS: A total of 125 chronic whiplash-associated patients completed multiple questionnaires and were subjected to pressure pain thresholds and temporal summation. RESULTS: . The Central Sensitization Inventory showed a strong association with ...

January 16, 2013. Have you heard the term central sensitivity syndrome (CSS)? Its a good one to know - researchers are using it more and more as an umbrella term for fibromyalgia, chronic fatigue syndrome and several other related illnesses.. These conditions have been called a lot of things, ranging from not real to functional somatic syndromes to neuroendocrineimmune disease. However, as researchers learn more about them, some are coming to the conclusion that CSS fits best because its based on their common underlying physiology - central sensitization. Thats what makes us hyper-sensitive to pain, sensory input, and, well, the world.. See what CSS means and which illnesses it covers:. ...

Do you remember my massive post about CSS, Central Sensitivity Syndrome? The basic premise was that some peoples hyper-sensitivity may be related to an amplification of certain neurotransmitter pathways which then cause reactivity, pain and mood changes. I detailed what kind of pathways go wrong and the mainstream meds currently being used to dampen them.…

Does acetaminophen activate endogenous pain inhibition in chronic fatigue syndrome-fibromyalgia and rheumatoid arthritis: a double-blind randomized controlled cross-over trial. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.

For some with Central Sensitization, electrical stimulation devices are a godsend. However, for others its a nightmare. Fortunately, electrical sensitivities are rare. For those without electrical sensitivity, there are several wonderful devices that may help you with your pain. The first is the well-known TENS Unit. Another is the lesser… ...

I was initially started on prescription medications for ADHD, and those resulted in new symptoms/side effects, and they continued to add more drugs to treat the side effects instead of taking me off the medications. It wasnt long before I was having psychotic episodes due to the medications because the side effects were so severe. Then, they put me on anti-psychotics which landed me institutionalized. One month later my Chronic Pain Specialist took me off all my medications and within 6 months, most of the side effects were gone and I was a completely different person (still disabled), but living healthy, strong, and independently.. Basically, I was severely high on drugs stating at age 7. I never had a chance. It got so bad my mother signed me over to the state because she couldnt deal with it anymore and was terrified of me. Then the state signed me back over to my mother because they couldnt deal with me anymore and were terrified of me. And then I spent 3 years living on and off the ...

Central sensitivity syndrome is a rising umbrella term for fibromyalgia, chronic fatigue syndrome and related conditions. See what that means.

INTRODUCTION The stimulus of surgical trauma provokes peripheral and central sensitivity, with modification of neurons and resulting in allodynia, hyperalgesia and increase of postoperative pain intensity1. It also causes increase in the concentrations of cytokines 2,3. Pro-inflammatory cytokines (TNF-α, IL-1, IL-6, IL-8) indirectly modulate pain through the release of substances like nitric oxide, oxygen free radicals, prostaglandins, and excitatory amino acids from microglia and astrocytes, inducing peripheral and central sensitivity and hyperalgesia 4. NMDA receptors have an important role in processing pain. The activation of these receptors by excitatory neurotransmitters, especially glutamate, is essential to the development of central sensitivity and amplification of pain response 1. Some drugs have been investigated to prevent or modify these alterations in the central nervous system. Ketamine is an antagonist of NMDA receptors and the S(+)-ketamine isomer is more powerful than the ...

This study describes the patient characteristics and healthcare utilization of a chronic pain population within an integrated healthcare system in northern California.

The nervous system sensitization process is usually triggered by something that is perceived as a threat. The trigger can be an accident, an emotional response, an immune response or any number of eve

Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and synaptic efficacy of neurons in central nociceptive pathways, the phenomenon of central sensitization. Central sensitization manifests as pain hypersensitivity, particularly dynamic tactile allodynia, secondary …

Fibromyalgia is currently understood to be a disorder of central pain processing or a syndrome of central sensitivity. Clauw describes the syndrome as a diffuse problem of sensory

Hi everyone, My doctor told me I have this, and thats why the pain is getting steadily stronger even though the IC probably isnt. I say probably isnt because pain is the only symptom at this point. There were some urinary symptoms in the beginning (1/07) and they disappeared after a few months. I know I should be grateful for that, and I really am. Im not sure I understand, though, what central sensitization means in terms of treatment. Does anyone know if central sensitization

Preclinical Findings Presented at the 2010 Joint Annual Meeting of the International Continence Society and the International Urogynecological Association Aug 2

Chapter 5 questions at Bradley University StudyBlue - Learn what central sensitization means, For example, you may not have a It may be due to any combination of the following:

This web site is run by an Arthritis Specialist based in Dubai, United Arab Emirates. On this site you will find news about the latest in arthritis, information about research results in the field, tips and information and diet and exercise, and much more.. More ...

Impaired central pain modulation is implicated in the pathophysiology of chronic pain. In this controlled experiment, we evaluated whether partial sleep loss altered endogenous pain inhibition and reports of spontaneous pain. Thirty-two healthy females were studied polysomnographically for 7 nights. …

Clinical examination findings are used in primary care to give an initial diagnosis to patients with low back pain and related leg symptoms. The purpose of this study was to develop best evidence Clinical Diagnostic Rules (CDR] for the identification of the most common patho-anatomical disorders in the lumbar spine; i.e. intervertebral discs, sacroiliac joints, facet joints, bone, muscles, nerve roots, muscles, peripheral nerve tissue, and central nervous system sensitization. A sensitive electronic search strategy using MEDLINE, EMBASE and CINAHL databases was combined with hand searching and citation tracking to identify eligible studies. Criteria for inclusion were: persons with low back pain with or without related leg symptoms, history or physical examination findings suitable for use in primary care, comparison with acceptable reference standards, and statistical reporting permitting calculation of diagnostic value. Quality assessments were made independently by two reviewers using the Quality

Thorn, Beverly, Day, Melissa, Burns, John, Kuhajda, Melissa, Gaskins, Susan, Sweeney, Kelly, McConley, Regina, Ward, L Charles and Cabbil, Chalanda. (2011) Randomized trial of group cognitive behavioral therapy compared with a pain education control for low-literacy rural chronic pain population. Pain. 152(12), pp. 2710 - 2720. https://doi.org/10.1016/j.pain.2011.07.007 ...

The BfArM would like to draw attention to the recent SCENIHR publication regarding the use of surgical meshes in urogynecological surgery.

Click the blue hyper link introduction to pericytes in the reference section. See also the hyperlink Regenexx.com in the reference section. Historical Background. The history and description of chronic pain actually began slightly prior to the Civil War. Dr. Thomas Weir Mitchell, described Causalgia after the Civil War, where soldiers returning from battle with chronic pain developed pain that was not in the location of their original injuries. He noted that the pain was in a different nerve distribution and thus, seemed to be a condition of the nerves.. Chronic Pain Theory. Currently, thanks to the remarkable work of a single physician in Christchurch, New Zealand, Dr. John Lyftogt has provided a new working hypothesis in chronic pain. That is neurogenic inflammation of the unregulated peptidergic sensory nervous system. His hypothesis is the up regulation of the peptidergic nervous system sensitization and swelling is responsible for the tenderness and expression of pain in chronic clinical ...

Background Opioid analgesics such as morphine and meperidine have been used to control moderate to severe pain for many years. However, these opioids have many side effects, including the development...

1005 Dr. D.B. Todd Jr. Boulevard Nashville, Tennessee 37208 , 615.327.5525. The Office for Research is located in room 2203 of the Harold D ...

Semantic Scholar extracted view of Pain perception and endogenous pain modulation in angina pectoris. by Christine A. Droste et al.

Subjective. - Getting paresthesia down the R LE that began 2 weeks ago after a car ride…has peripheralized since initial event.. - Symptoms are aggravated with static sitting or standing…onset ranging from seconds to minutes.. - Has tried loading/unloading MDT strategies, neurodynamics, Mulligan techniques, IASTM, compression wrapping, etc…all to no avail.. Objective (major findings). - Limited B Apleys scratch (1 per FMS scoring). - Negative slump and ASLR. - Painful lumbar motions of extension, right rotation and sidebend. R sidebend was limited.. - Negative thomas test on left, positive on right. - Slight limitations in active seated hip IR B, R,L.. - Adduction lift scores 1/5 B.. My Impression. If I were to classify Erson, it seems his symptoms would seems to be more dominant as peripheral nociceptive ischemic and central sensitivity (he stated he has always had findings with his back). I was less inclined to think he had peripheral neuropathic issues, at least yet, based on ...

Hi I have recently been diagnosed with Central Sensitisation and Chronic Migrainous State. This is after three years of a range of strange symptoms which I did

The proposed study intends to utilize a psychobehavioral protocol from Darnall and colleagues to deliver a single session behavioral medicine for pain intervention for the spine surgery patient entitled TREK (Transform, Restore, Empower, Knowledge) for Surgical Success (TREK for SS). The intervention is based off of the above noted evidence based 2 hour pain psychology class that has been used in the chronic pain population and is also currently being tested in other surgical populations. Use of this established and evidenced based treatment for the proposed project enhances the treatment fidelity. The proposed project addresses questions in the literature such as the benefits of this class in an in-person or online format and its adaptability and effectiveness in the spine surgery population.. The primary objective of the proposed project is to determine the feasibility of a single session digital behavioral medicine for pain intervention (TREK for SS) offered the perioperative period of ...

The American Urogynecologic Society and the International Urogynecological Association have honored the University of Alabama at Birminghams Dep...

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Understanding the perception of pain is important in the treatment of many conditions. When a tissue in the body is damaged, peripheral sensitization of nociceptors occurs as a protective mechanism by the body in order to prevent further use of a damaged structures (which if used, could further damage the tissue as well as surrounding…

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TriAgain, my experience has been similar. Triathlon to joint pain. Except mine started with my hips and the other important difference I have to say Ive sadly had no progress. What I find works best for me is flow. By which I mean if I get into a state where I am completely and utterly absorbed by whatever Im doing and am happy then the pain seems to resolve to some extent. Im not sure if this is the bodys endogenous pain killers - endomorphine and endocannabinoid pathways or something else. It would kind of make sense as it seems to last for a while afterwards. Its not just a case of being diverted. It lasts longer than the diversion. I have been increasingly speculating that being stressed and focussed on the pain not just amplifies the pain which I think is pretty well established in the academic literature but causes actual joint damage. Ive actually found a serious academic paper which kind of makes this leap. The nervous system goes two ways. You sensory receptors send signals to the ...

Chemists at LMU Munich have collaborated with colleagues at Berkeley and Bordeaux to perform a series of lab experiments on pain inhibition and pain-sensitive neurons. They have discovered something like a pain switch, allowing the inhibition of the activity of pain-sensitive neurons. Findings were published in February of this year in Nature Methods. The researchers…

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BACKGROUND Fibromyalgia Syndrome (FMS) is a persistent and debilitating disorder estimated to impair the quality of life of 2-4% of the population, with 9:1 female-to-male incidence ratio. FMS is an important representative example of central nervous system sensitization and is associated with abnormal brain activity. Key symptoms include chronic widespread pain, allodynia and diffuse tenderness, along with fatigue and sleep disturbance. The syndrome is still elusive and refractory. The goal of this study was to evaluate the effect of hyperbaric oxygen therapy (HBOT) on symptoms and brain activity in FMS. METHODS AND FINDINGS A prospective, active control, crossover clinical trial. Patients were randomly assigned to treated and crossover groups: The treated group patients were evaluated at baseline and after HBOT. Patients in the crossover-control group were evaluated three times: baseline, after a control period of no treatment, and after HBOT. Evaluations consisted of physical examination, including

Background Fibromyalgia Syndrome (FMS) is a persistent and debilitating disorder estimated to impair the quality of life of 2-4% of the population, with 9:1 female-to-male incidence ratio. FMS is an important representative example of central nervous system sensitization and is associated with abnormal brain activity. Key symptoms include chronic widespread pain, allodynia and diffuse tenderness, along with fatigue and sleep disturbance. The syndrome is still elusive and refractory. The goal of this study was to evaluate the effect of hyperbaric oxygen therapy (HBOT) on symptoms and brain activity in FMS. Methods and Findings A prospective, active control, crossover clinical trial. Patients were randomly assigned to treated and crossover groups: The treated group patients were evaluated at baseline and after HBOT. Patients in the crossover-control group were evaluated three times: baseline, after a control period of no treatment, and after HBOT. Evaluations consisted of physical examination, including

Background Fibromyalgia Syndrome (FMS) is a persistent and debilitating disorder estimated to impair the quality of life of 2-4% of the population, with 9:1 female-to-male incidence ratio. FMS is an important representative example of central nervous system sensitization and is associated with abnormal brain activity. Key symptoms include chronic widespread pain, allodynia and diffuse tenderness, along with fatigue and sleep disturbance. The syndrome is still elusive and refractory. The goal of this study was to evaluate the effect of hyperbaric oxygen therapy (HBOT) on symptoms and brain activity in FMS. Methods and Findings A prospective, active control, crossover clinical trial. Patients were randomly assigned to treated and crossover groups: The treated group patients were evaluated at baseline and after HBOT. Patients in the crossover-control group were evaluated three times: baseline, after a control period of no treatment, and after HBOT. Evaluations consisted of physical examination, including

There also appears to be a connection between IC and other syndromes such as chronic fatigue syndrome (CFS), fibromyalgia, irritable bowel syndrome and vulvodynia and dyspareunia (pain on intercourse).All may have a connection between what has been called Central Sensitivity Syndrome (CSS).. Patients with CSS become sensitised to things that are processed by the central nervous system: lights, odours, smell, touch and pressure on the body. This explains the connection between the above conditions and also the following: migraines, restless legs syndrome, multiple chemical sensitivity, temperomandibular joint dysfunction (TMJ) and dysmenorrhoea (painful periods). Some patients have more than one condition, and this helps make sense of the connection.. It appears irritable bowel syndrome, interstitial cystitis and reproductive and pelvic pain may have a connection through nerve pathways in the pelvis. Researchers have demonstrated a cross-sensitisation between nerves in the bladder, bowel and ...

Scotopic sensitivity syndrome, also known as Irlen Syndrome and Visual Stress Syndrome, approximating in some ways to Meares Irlen syndrome, and Visual Stress, refers to visual perceptual disorder(s) affecting primarily reading and writing based activities.

Scotopic sensitivity syndrome is a disorder that leads to a variety of symptoms that are related to vision. The signs of scotopic...

Abramowitch, S.D., 2013, Mesh Complications: Hypothesizing About the Cause, American Urogynecological Societys Mesh special Interest Group, Las Vegas, NV.. Abramowitch, S.D., 2013, Trying to Clean Up the Mess of Urogynecological Mesh, Biomedical Engineering Graduate Seminar Series, The University of Akron.. Abramowitch, S.D., 2013, Urogynecological Mesh: The Data is Long Overdue, Engineering Science and Mechanics Seminar Series, Virginia Tech University.. Abramowitch, S.D., Maiti, S., Moalli, P., Pal, S., and Thunes, J.R., 2013, Stiffness Mismatch between Prolapse Meshand Vaginal Tissue Impacts Stresses in the Vagina, 34th Annual Meeting of American Urogynecologic Society, Las Vegas, NV.. Barone, W.R., Amini, R., Maiti, S., Moalli, P.A., and Abramowitch, S.D., 2013, Surface Curvature of CommonProlapse Meshes Alters under Variable Loading Conditions, 34th Annual Meeting of American Urogynecologic Society, Las Vegas, NV.. Barone, W.R., Moalli, P.A., and Abramowitch, S.D., 2013, ...

OBJECTIVE: The neural mechanisms of pain in knee osteoarthritis (OA) are not fully understood, and some patients have neuropathic-like pain associated with central sensitization. To address this, we undertook the present study in order to identify central sensitization using neuroimaging and PainDETECT and to relate it to postarthroplasty outcome. METHODS: Patients awaiting arthroplasty underwent quantitative sensory testing, psychological assessment, and functional magnetic resonance imaging (fMRI). Neuroimaging (fMRI) was conducted during punctate stimulation (n = 24) and cold stimulation (n = 20) to the affected knee. The postoperative outcome was measured using the Oxford Knee Score, patient-reported moderate-to-severe long-term pain postarthroplasty, and a range of pain-related questionnaires. RESULTS: Patients with neuropathic-like pain presurgery (identified using PainDETECT; n = 14) reported significantly higher pain in response to punctate stimuli and cold stimuli near the affected joint (P | 0

Ethnic differences in central sensitization of pain processing and stress-relevant endogenous pain regulatory mechanisms were examined. Forty-four African Americans (AAs; 50% women) and 44 non-Hispanic Whites (nHWs; 50% women) matched for socioeconomic status, were tested for pain responses to the temporal summation of heat pulses and ischemic and cold pain. Resting and stress blood pressure (BP) and norepinephrine (NE) were assessed. AAs had heightened pain responses to all 3 pain tasks relative to nHWs. In nHWs, higher BP and NE were related to reduced pain. In AAs, there was no relationship between BP and pain, but higher NE was related to increased pain. This study provides evidence for ethnic differences in centrally mediated pain and extends prior research demonstrating ethnic differences in endogenous pain regulatory mechanisms. These results have implications for understanding biobehavioral factors contributing to ethnic disparities in clinical pain ...

A 20 year old myopic Sudanese female presented at our hospital with a central visual field defect of her right eye, associated with photopsia. Visual acuity was 0.3; intraocular pressure was 16 mm Hg. Funduscopic examination of the affected eye showed some pigment epithelial alterations in the macular area, with an irregular macular reflex. Upon visual field examination, the affected eye showed a 12 dB decrease in central sensitivity, and a small blind spot enlargement was seen. No such changes were found in the left eye. OCT showed degeneration or disarray of foveal photoreceptor outer segments in the ...

These data identify the hypothalamic ObRb as a gene modulated after metformin treatment and suggest that the anorectic effects of the drug are potentially mediated via an increase in the central sensitivity to leptin ...

Bo K, Frawley HC, Haylen BT, Abramov Y, Almeida FG, Berghmans B, Bortolini M, Dumoulin C, Gomes M, McClurg D, Meijlink J, Shelly E, Trabuco E, Walker C, Wells A. An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for the conservative and nonpharmacological management of female pelvic floor dysfunction. Int Urogynecol J 2017 Feb; 28 (2):191-213 Epub 2016 Dec 05 ...

Some surgeons work with other medical professionals in order to treat complex cases: such as a colorectal surgeon, urogynecological surgeon, or thoracic surgeon. This does not mean that the specialist has a lower skill set by any means. While a group of surgeons are now using robotic surgery, some have opted to continue using traditional surgical techniques. This does not mean that one is better or more qualified than the other. Surgery is not based on the tools used, but the hands controlling the tools and the knowledge behind those hands. ...

By Andy Choi OrthoSensor, the developer of sensor-assisted surgery systems and intelligent orthopedic implants based in Sunrise, Florida, has announced that its

C) no, not necessarily... it depends how much damage there is... but pain sensation is both a physiological and psychological responce... many people have very traumatic sports injuries and they dont feel the pain to much after the event... as adrenaline may well delay a pain responce... but we also have other endogenous pain killers in bodies (endogenous opioids, neurotransmitters...etc ...

MT Pinto joined Ipatimup as an Investigator Ciência 2008 (2009) of the Cancer Genetics Group and was mainly dedicated to the study of cancer related features using the CAM model. After setting up the lab and implementing several CAM assays, she established the In vivo CAM assays service at Ipatimup (2012) and founded the spin-off Expertus, CAM assays (2013-2015). MT Pinto graduated in Biochemistry (FCUP; 1999) and both MSc (FMUL; 2001) and PhD (FMUP; 2008) theses concerned the study of the endogenous pain control system in acute and chronic pain states and involved extensive use of animal models. MT Pinto has published 26 papers in international peer reviewed journals (Q1) with an H index of 12 (ResearcherID: J-2519-2013). She is co-author of two patents. ...