TY - JOUR. T1 - Quantitative characterization of preneoplastic progression using single-cell computed tomography and three-dimensional karyometry. AU - Nandakumar, Vivek. AU - Kelbauskas, Laimonas. AU - Johnson, Roger. AU - Meldrum, Deirdre. PY - 2011/1/1. Y1 - 2011/1/1. N2 - The development of morphological biosignatures to precisely characterize preneoplastic progression necessitates high-resolution three-dimensional (3D) cell imagery and robust image processing algorithms. We report on the quantitative characterization of nuclear structure alterations associated with preneoplastic progression in human esophageal epithelial cells using single-cell optical tomography and fully automated 3D karyometry. We stained cultured cells with hematoxylin and generated 3D images of individual cells by mathematically reconstructing 500 projection images acquired using optical absorption tomographic imaging. For 3D karyometry, we developed novel, fully automated algorithms to robustly segment the cellular, ...

Background and objective: Clear Cell Renal Cell Carcinoma (CCRCC) is the most common adult renal neoplasm. Staging and grading of RCC are important predictors of survival. Fuhrman nuclear grading is widely used for CCRCC, the subjective nature of which has prompted more objective methods to evaluate nuclear features. Furthermore, Ki-67, a reliable marker of cellular proliferation may provide another variable for assessment of the biological behavior of RCC. The aim of this research was to study nuclear morphometry and Fuhrman nuclear grading of clear cell RCC, and to assess their relationship with the Ki-67 index. Methods: Hematoxylin and eosin slides of forty cases of CCRCC were retrieved and studied for pathologic variables, including Fuhrman nuclear grade, pathological tumor and node stage. Nuclear morphometric analysis was performed using computer-assisted image analysis. The relationship between Fuhrman nuclear grading, pathologic stage, tumor size, nuclear morphometry and proliferative index were

These images are intended for educational purposes and may be freely used for such as long as the Papanicolaou Society and the Bethesda System for Reporting Thyroid Cytopathology is credited ...

The p53-ull mammary epithelial model differs from the traditional mouse models of mammary tumorigenesis in several fundamental biological properties (5 , 6) . The traditional mouse models of mammary tumorigenesis, which are induced by mouse mammary tumor virus standard, arise from alveolar hyperplasias. These alveolar hyperplasias are negative for ER at the onset and generate ER-negative, hormone-independent tumors. In chemical carcinogen-treated mice, tumors arise from both alveolar hyperplasias and ductal hyperplasias. However, tumors are primarily hormone independent. Because the p53-null normal mammary epithelium and the serially transplanted, immortalized ductal outgrowths were ER positive, it was of interest to determine the hormonal dependency of preneoplastic progression in these cells.. The hormonal dependency of the p53-null normal mammary epithelium is indistinguishable from that of the p53 wild-type epithelium. Previous results demonstrated that growth and morphogenesis in ...

Subjective assessment of flat urothelial lesions has often resulted in an under- or overdiagnosis of urothelial carcinoma in situ. To identify reproducible morphologic objective criteria, the authors used an image analysis system to measure several nuclear features (area, diameter, roundness, ellipticity, and optical density) in 20 cases each of CIS, urothelial dysplasia, and normal urothelium with adjacent lymphocyte controls. They did not analyze reactive urothelial lesions and umbrella cells. The most useful, statistically significant morphologic parameter was mean nuclear area of the largest 25 percent of nuclei. The mean upper quartile nuclear area relative to lymphocytes was 2.2 times (range, 1.4 to 2.8 times) in normal urothelium, 2.9 times (range, 1.8 to 3.6 times) in urothelial dysplasia, and 4.9 times (range, 4.0 to 7.6 times) in CIS. The nuclear size measurements for urothelial dysplasia and normal urothelium overlapped, but the separation between CIS and urothelial dysplasia was ...

Cells were established and maintained in Leibowitz medium, with 20% fetal calf serum diluted to 60% with H2O at 24°C. Determinations of nuclear diameter by phase-contrast microscopy, of height by electron microscopy, and of pore frequency by freeze-etching were done on cells during the exponential growth phase (48 h after plating). For determination of nuclear size the short and long axis of 50 live cells were measured and averaged separately ...

Simultaneous use of cell-permeant and impermeant fluorescent nuclear dyes is a common method to study cell viability and cell death progression. Although these assays are usually conducted as end-point studies, time-lapse imaging offers a powerful technique to distinguish temporal changes in cell viability at single-cell resolution. SYTO 13 and Hoechst 33342 are two commonly used cell-permeant nuclear dyes; however their suitability for live imaging has not been well characterized. We compare end-point assays with time-lapse imaging studies over a 6 h period to evaluate the compatibility of these two dyes with longitudinal imaging, using both control neurons and an apoptotic neuron model. In longitudinal assays of untreated neurons, SYTO 13 addition caused acute necrosis within 3 h, whereas neurons imaged with Hoechst remained viable for at least 6 h. In a staurosporine-induced apoptotic model of neurotoxicity, determinations of the mode of cell death and measurements of nuclear size were identical

TSC and CNI genome sizes based on the sum of chromosome sizes are close to GGA, but these sizes are smaller than those in the database [1]. The larger genome sizes were obtained from the measurement of nuclear DNA content at cellular level. Both methods differ from DNA sequencing in that they require a DNA reference point from another species. When the reference species used for nuclear measurement is distantly related from the target species, the result may be influenced by varying fluorescence intensity owing to species variation in cell or nuclear sizes. In contrast to cells, chromosome structure shows little variation between species, and human chromosomes can be used as a reference for many species, even for zebrafish [6]. Our measurement of 1.15 Gb for GGA is consistent with 1.05 Gb of the assembled sequence [19], showing that chromosome measurement has a high accuracy. Therefore, our method is to be preferred where whole-genome sequence is unavailable. Our data refine previous ...

Implementation of an intraoperative UV-PAM system for breast tumor excision could be transformative. Our UV-PAM system was able to image fixed, unprocessed breast tumors with an image quality comparable to that of conventional histology using processed, paraffin-embedded, sectioned, and H&E-stained specimens (Figs. 3 and 4 and fig. S4). Although fixed breast tumors were imaged in this study to maintain tissue integrity during relatively long intervals between surgery and processing for histology, fresh breast tumors are expected to provide similar imaging contrast (33). With relevant information regarding such tissue features as the average nuclear size and internuclear distance (Fig. 5), typically obtained from histology, UV-PAM images could be used to detect cancer cell clusters at the margins of tissue specimens during a surgical procedure, allowing immediate action to achieve clear margins. Although benign breast epithelial cells are too few in the UV-PAM images to be compared with cancer ...

The induction of polyploidy is considered the reproductive end of cells, but there is evidence that polyploid giant cancer cells (PGCCs) contribute to cell repopulation during tumor relapse. However, the role of these cells in the development, progression and response to therapy in colon cancer remains undefined. Therefore, the main objective of this study was to investigate the generation of PGCCs in colon cancer cells and identify mechanisms of formation. Treatment of HCT-116 and Caco-2 colon cancer cells with the hypoxia mimic CoCl2 induced the formation of cells with larger cell and nuclear size (PGCCs), while the cells with normal morphology were selectively eliminated. Cytometric analysis showed that CoCl2 treatment induced G2 cell cycle arrest and the generation of a polyploid cell subpopulation with increased cellular DNA content. Polyploidy of hypoxia-induced PGCCs was confirmed by FISH analysis. Furthermore, CoCl2 treatment effectively induced the stabilization of HIF-1α, the differential

Adult neurogenesis is studied in the mouse hippocampus frequently. was a steady signal of the level of a cells structural growth and could end up being utilized simply because a straightforward parameter of granule cell advancement. As a result, additional research could make use of our doublecortin-staging program and nuclear size dimension to perform inspections of morphological Rabbit Polyclonal to OR4A16 advancement in mixture with useful research of adult-born granule cells. Furthermore, the Thy1-GFP transgenic mouse model can end up being utilized as an extra analysis device because the news reporter gene brands granule cells that are 4 weeks or old, while extremely youthful cells could end up being visualized through the premature gun doublecortin. This will enable comparison studies regarding the function and structure between young immature and older matured granule cells. Launch Adult neurogenesis is certainly a procedure in which brand-new neurons are produced from sensory control ...

Segmentation of nuclei in cervical cytology pap smear images is a crucial stage in automated cervical cancer screening. The task itself is challenging due to the presence of cervical cells with spurious edges, overlapping cells, neutrophils, and artifacts. After the initial preprocessing steps of adaptive thresholding, in our approach, the image passes through a convolution filter to filter out some noise. Then, contours from the resultant image are filtered by their distinctive contour properties followed by a nucleus size recovery procedure based on contour average intensity value. We evaluate our method on a public (benchmark) dataset collected from ISBI and also a private real dataset. The results show that our algorithm outperforms other state-of-the-art methods in nucleus segmentation on the ISBI dataset with a precision of 0.978 and recall of 0.933. A promising precision of 0.770 and a formidable recall of 0.886 on the private real dataset indicate that our algorithm can effectively detect and

In the nuclear area, the proportion of microtubule-dependent, directed movement actually increases. Microtubules are not known to exist in interphase nuclei, so the authors suggest that the virus is travelling along invaginations in the nuclear envelope that have been observed by others. These invaginations may provide rapid access to the nuclear volume for both cellular materials and virus particles. Indeed, the speed of infection (with nuclear entry as an endpoint) is fast. Previous estimates of a two-hour infection were limited by the need to detect multiple virus particles. The new methods yield a figure of just 15 min.Bräuchle says the method can be used to track any virus, and might help gene therapists understand where their virus of choice is getting held up during the infection process. Meanwhile, he has made virus labeled on both capsid and DNA, so that he can track the exact location and kinetics of viral disassembly. ▪ ...

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I have mentioned the fact that, as the % of voids in the crushing chamber decreases, the production of fines by attrition increases. This is like saying that, as the Crusher Reduction Ratio in any given crusher is increased, the % of fines in the product will increase, even though the discharge setting remains unchanged. Both of these statements are true, but the degree to which the product is .... ...

Pdf size reduction by crushing methodspdf size reduction by crushing methodsAnd now impact stone crusher has been applied in the field of mines highspeed railway hig hway cement chemicals constructionetc working principle of impact stone cru sher, crusher stone principle

5) p By clustered MDS 1. The size reduction of liposomes with a high pressure homo- genizer (MicrofluidizerOМ). 17.1999; Anderson et al.

Feeding Size In Ball Mill Filetype Pdf. feeding size in ball mill filetype pdf Ball Mill Design Filetype Pdf ball mill calculation pdf Grinding for the best and optimum/ideal or target grind size to be, A ball mill is a type of grinder used to grind and blend materials for size reduction is done by impact as the balls drop (or drop down on to the feed),.. Get price >> ...

Murrysville Machinery Company carries a selection of industrial crushers for your raw materials that are larger than what they can directly use or sell to other companies. A rock crusher offers efficient size reduction of these materials. by large industrial crushers include certified coarse aggregates for road construction, Get Price ...

This publication describes the procedures for calculating the margins of nuclear power plants in relation to human induced external hazards. It focuses on plant and systems performance evaluations. A two level approach for margin assessment is provided. The first level consists of a deterministic procedure in which for each scenario the existence of at least one undamaged success path to comply with the fundamental safety function is investigated. This procedure can be subsequently extended to calculate probability measures such as conditional core damage probability and the conditional probability of spent fuel damage. In the most elaborated stage probabilistic safety assessment (PSA) techniques are introduced giving consideration to the probabilistic aspects of the hazards and of the capacity of structures systems and components (fragility). Event tree and fault tree models are used to compute PSA metrics such as core damage frequency large early release frequency and frequency of spent fuel ...

Parakeratosis is a mode of keratinization characterized by the retention of nuclei in the stratum corneum. In mucous membranes, parakeratosis is normal. In the skin, this process leads to the abnormal replacement of annular squames with nucleated cells. Parakeratosis is associated with the thinning or loss of the granular layer and is usually seen in diseases of increased cell turnover, whether inflammatory or neoplastic. Parakeratosis is seen in the plaques of psoriasis and in dandruff. Granular parakeratosis (originally termed axillary granular parakeratosis) is an idiopathic, benign, nondisabling cutaneous disease that manifests with intertriginous erythematous, brown or red, scaly or keratotic papules and plaques. It presents in all age groups and has no established clinical associations. Skin lesion Skin disease List of skin diseases Kumar, Vinay; Fausto, Nelson; Abbas, Abul (2010) Robbins & Cotran Pathologic Basis of Disease (8th ed.). Saunders. Page 1170. ISBN 978-1-4160-3121-5. ...

Thank you for sharing this Cancer Epidemiology, Biomarkers & Prevention article.. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.. ...

Summary A measurement of the 2S-2P transition frequencies (Lamb shift) in the muonic helium-3 and 4 ions by means of laser spectroscopy is proposed. This will lead to a ten times more accurate determination of the root-mean-square (rms) charge radii of the He-3 and He-4 nuclei. The radius of the magnetic moment distribution inside the He-3 nucleus will result from the hyperfine structure in muonic 3He. In the muonic helium ion, a single negative muon orbits the helium nucleus. The muon is a point-like lepton, just as the electron, except it is about 200 times heavier. This gives a factor of 200^3 = 10^7 enhancement of nuclear finite size effects on the energy levels of muonic vs. regular (electonic) Helium ions. Muonic helium is the ideal sytem to study the He nuclear size. The CREMA project has four main aims: (1) Solve the proton size puzzle created by our recently completed muonic hydrogen project [R. Pohl et al., The size of the proton, Nature 466, 213 (2010)]. Our tenfold ...

Abstract. Keratinocytes in skin epidermis, which have. bright cytoplasmic contrast and dark nuclear contrast in reflectance. confocal microscopy (RCM), were modeled with. a simple error function reflectance profile: erf( ). Fortytwo. example keratinocytes were identified as a training. set which characterized the nuclear size a = 8.6±2.8. μm and reflectance gradient b = 3.6±2.1 μm at the nuclear/. cytoplasmic boundary. These mean a and b parameters. were used to create a rotationally symmetric erf( ) mask. that approximated the mean keratinocyte image. A computer. vision algorithm used an erf( ) mask to scan RCM. images, identifying the coordinates of keratinocytes. Applying. the mask to the confocal data identified the positions. of keratinocytes in the epidermis. This simple model. may be used to noninvasively evaluate keratinocyte populations. as a quantitative morphometric diagnostic in skin. cancer detection and evaluation of dermatological cosmetics.. C2011 Society of Photo-Optical ...

Particle Size Reduction Pharmaceutics, Particle Size Reduction Pharmaceutics, Particle size reduction, There are several strategies and delivery technologies that use particle size reduction as a route to successful dosage formulation, Quay Pharma have working partnerships with a number of companies who specialise in reducing particle size in APIs.

For speedy, intra-operative pathological margin assessment to steer staged cancers excisions, multimodal confocal mosaic check picture wide surgical margins (approximately 1?cm) with sub-cellular resolution and mimic the appearance of conventional hematoxylin and eosin histopathology (H&E). The goal of this work is definitely to combine three confocal imaging modes: acridine orange fluorescence (AO) for labeling nuclei, […]. ...

The resection rate is defined as the fraction of patients that proceed to planned surgery with removal of primary tumor (R0/R1) following neoadjuvant treatment with gemcitabine plus erlotinib.The resection rate will be estimated by the binomial point estimate, i.e. as the number of patients that undergo the planned surgery with removal of the primary tumor following neoadjuvant treatment with gemcitabine plus erlotinib divided by the number of evaluable patients. This quantity will also be estimated with a 95% binomial confidence interval.. Curative resection (R0) is defined as macroscopically and microscopically complete resection (with microscopic surgical margin assessment according to AJCC Staging Principles).. An R1 resection is defined as macroscopically complete tumor removal with any positive microscopic surgical margin (bile duct, pancreatic parenchyma, or SMA margins). ...

The resection rate is defined as the fraction of patients that proceed to planned surgery with removal of primary tumor (R0/R1) following neoadjuvant treatment with gemcitabine plus erlotinib.The resection rate will be estimated by the binomial point estimate, i.e. as the number of patients that undergo the planned surgery with removal of the primary tumor following neoadjuvant treatment with gemcitabine plus erlotinib divided by the number of evaluable patients. This quantity will also be estimated with a 95% binomial confidence interval.. Curative resection (R0) is defined as macroscopically and microscopically complete resection (with microscopic surgical margin assessment according to AJCC Staging Principles).. An R1 resection is defined as macroscopically complete tumor removal with any positive microscopic surgical margin (bile duct, pancreatic parenchyma, or SMA margins). ...

Breast cancer often requires surgical treatment including breast-conserving surgical resection. However, with current post-surgical histological margin analysis, one-quarter of breast cancer patients undergo re-excision to achieve negative margins corresponding to decreased local recurrence and better outcomes. Therefore, a method with high resolution and specificity for intraoperative margin assessment is needed.

Archival paraffin embedded material was used to examine whether additional quantitative criteria would be helpful to discriminate between histologically benign and malignant rat mammary tumours. To this end nuclear DNA content expressed as DNA ploidy index (DI) was measured using flow cytometry (FCM). A total of 63 benign and malignant mammary tumours were investigated. Thirteen out of 38 (34%) mammary carcinomas were DNA aneuploid against 0 out of 25 benign mammary tumours. Aneuploidy was not significantly increased in tumours showing histological signs of greater malignancy such as cribriform-comedo type or invasive growth. In addition to DI other quantitative criteria indicative for malignancy, such as mitotic count and nuclear morphometric characteristics, were estimated in 24 benign and malignant tubulopapillary tumours, a category where the histological classification may be difficult. It appeared that five out of nine noninvasive tubulopapillary carcinomas and six out of seven invasive ...

Particle Size Reduction Methods: Which Is Best Sep 02, 2016 路 Particle size reduction is a crucial initial step in the production of countless end products across all manufacturing industries. Think of wheat that needs to be ground in the production of flour, or rocks and rubble that must be crushed i. View Details Send Enquiry ...

List of %result_count% doctors offering Breast size reduction in Hawthorn East. Check out patient reviews, addresses and book a visit!

Lezione 8 del corso elearning di Equipment and Industrial Plants for Food Industries. Prof. Fabrizio Sarghini. Università di Napoli Federico II. Argomenti trattati: Size reduction.

lime slaking and wet limestone ball mill grinding process lime slaking and wet limestone ball mill grinding process overflow with a new approach for particle size reduction abstrac being an integral part of the typical fgd system, the design and performance of the reagent preparation More Info > Live Chat ...

Particle Size and Standard Deviation - CPMProduct 15 - 40 . . to particle size reduction. Increasing energy costs, increasing customer awareness of . choice for particle size reduction (grinding) applications. . For certain special applications such as high moisture grain, some form of a raked tooth with different . In many cases, this reduction in noise means a roller.dental grinding particle size customer case,Particle Grinding & Milling Services- Woodbury, MinnesotaAVEKAs particle grinding and milling services are useful for a variety of industries . Using Multiple Processes To Solve a Customers Needs · Milling and size . In each case, media, typically larger than the material to be ground, is added to a.Particle Size Reduction Solutions - PraterMany decades and 6,000 customers later, Praters products are some of the most versatile and . Prater Particle Size Reduction Application Case Studies.. ...

Union Process is a trusted provider of particle size reduction equipment and supplies, including grinding balls, Attritors, product and laboratory mills, and bead mills.

The secondary electron emission from a Scanning Electron Microscope (SEM) was used to determine that the pore spaces of seven sandstones and four dolomites exhibited fractal behavior over certain length scales. Data from the SEM measurements produced log-log plots that not only verified the fractal nature of the rocks, but also allowed for the determination of their fractal dimensions. To model the transport properties of fractal lattices, a two dimensional model known as the Sierpinski Carpet was used as a starting point. Results developed for the petrophysical properties of such fractal lattices, such as porosity, permeability, capillary pressure, et. are presented here. Although the results cannot be directly compared with experiments, they demonstrate a methodology that can be applied to three dimensional lattices as well. A variation of a three dimensional fractal structure known as the Menger Sponge was used to model the pore spaces in rocks in an attempt to determine transport properties of rocks

Which type of mill is used for a particular particle size reduction task always depends on the breaking properties of the sample material. Size reduction machines for large particle sizes above40 mmare known as crushers or shredders while particle sizes below this are processed with mills. The most common mechanisms for the particle size reduction of solids are explained below.

Best practice advice on milling and particle sizing equipment for manufacturers in pharmaceuticals, chemical, nutraceutical and food ingredient processing

Jun 14 2018 · The Function of a Ball Mill . To perform its functions the ball mill operates on the principle of impact and attrition. This principle entails that the balls are dropped from near the top of the shell in order to bring about size reduction impact. The major components of the ball mill include a shell that is hollow and is suspended on its axis Get Price ...

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Abstract Background In addition to breast imaging, ultrasound offers the potential for characterizing and distinguishing between benign and malignant breast tissues due to their different microstructures and material properties. The aim of this study was to determine if high-frequency ultrasound (20-80 MHz) can provide pathology sensitive measurements for the ex vivo detection of cancer in margins during breast conservation surgery. Methods Ultrasonic tests were performed on resected margins and other tissues obtained from 17 patients, resulting in 34 specimens that were classified into 15 pathology categories. Pulse-echo and through-transmission measurements were acquired from a total of 57 sites on the specimens using two single-element 50-MHz transducers. Ultrasonic attenuation and sound speed were obtained from time-domain waveforms. The waveforms were further processed with fast Fourier transforms to provide ultrasonic spectra and cepstra. The ultrasonic measurements and pathology types were

I will report on recent polarization transfer experiments carried out at the Mainz Microtron (MAMI), via the quasi-elastic A(e ⃗,e^ p ⃗ ) reaction, over a wide range of missing momentum and virtuality. We measured the ratio (Px/Pz)A of the transverse to longitudinal components of polarization transferred from an electron to a bound proton in 2H and 12C [1, 2] , and transverse (Px and Py) and longitudinal (Pz) components of the polarization transfer to a bound proton in 2H [3]. We observed consistent deviations from unity of the above ratio normalized to the free-proton ratio, (Px/Pz)A/(Px/Pz)1H, for both s-and p-shell knocked out protons, even though they are embedded in averaged local densities that differ by about a factor of two. The dependence of the double ratio on proton virtuality is similar to the one for knocked out protons from 2H and previous 4He data, suggesting a universal behavior, which seems to be independent of nuclear size, density and Q2. A precise determination of the ...

Background: Brain imaging studies suggest that volume reductions and compromised white matter integrity occur in schizophrenia and bipolar disorder (BD). However, the cellular correlates have not yet been identified. To address this issue we assessed oligodendrocyte, astrocyte and microglial populations in postmortem white matter from schizophrenia, BD and nonpsychiatric control samples. Methods: The density, areal fraction and spatial distribution of glial fibrillary acidic protein (GFAP)-expressing astrocytes and ionized calcium-binding adaptor molecule-1 (IBA-1)-expressing microglia as well as the density, nuclear size and spatial distribution of Nissl-stained oligodendrocytes were quantified in postmortem white matter adjacent to the dorsolateral prefrontal cortex (Brodmann area 9) in schizophrenia, BD and control samples (n = 20). In addition, the oligodendrocyte-associated proteins myelin basic protein and 2′,3′-cyclic-nucleotide 3′-phosphodiesterase (CNPase) were quantified in the ...

TY - JOUR. T1 - Fibrillogenesis of huntingtin and other glutamine containing proteins. AU - Lyubchenko, Yuri L.. AU - Krasnoslobodtsev, Alexey V.. AU - Luca, Sorin. PY - 2012. Y1 - 2012. N2 - This chapter focuses on the aggregation of glutamine containing peptides and proteins with an emphasis on huntingtin protein, whose aggregation leads to the development of Huntingtons disease. The kinetics that leads to the formation of amyloids, the structure of aggregates of various types and the morphological mechanical properties of amyloid fibrils are described. The kinetics of amyloid fibril formation has been proposed to follow a nucleation dependent polymerization model, dependent upon the size of the nucleus. This model and the effect of the polyglutamine length on the nucleus size are reviewed. Aggregate structure is characterized at two different levels. The atomic-scale resolution structure of fibrillar and crystalline aggregates of polyglutamine containing proteins and peptides was determined ...

Latest information about hyperkeratosis parakeratosis Find article, review, images and graphics related with hyperkeratosis parakeratosis here.

0004] Standard assessment of a resection is performed by inking the outside of the excised tissue, freezing it and then examining the edge of specimen sections by light microscopy (known as frozen section analysis). The presence of tumor cells at the inked margin, which is referred to as a positive margin, indicates that tumor cells remain behind in the tumor bed. Although margin assessment of a frozen section can take place during surgery, time constraints normally limit this assessment to small areas of the tumor. Therefore, this approach is prone to sampling error. The remaining excised tissue is fixed in formalin and it may take several days before the pathologist can complete the analysis to identify a positive margin. If a positive margin is identified, patients most often require a repeat surgical resection, leading to increased patient morbidity and higher healthcare costs. Other intraoperative cancer detection technologies have been developed including radio-frequency (RF) spectroscopy ...

The poor performance of preoperative imaging in predicting tumor area in HER2-positive breast cancer may raise a question regarding the increase in positive margin rates or secondary operation for margin clearance in patients with HER2-positive breast cancer. Indeed, the relationship of imaging-pathologic size was least correlated in the HER2-positive subtype. This provided a rationale for the highest rate of positive margin as 23.2% in the HER2-positive subtype. The difference in re-excision rate was not significant between the subtypes, which might be largely attributable to the intraoperative frozen section examination that enables further resection in case of intraoperative-positive margins. If the intraoperative margin assessment is not performed, the correlation between imaging and pathologic size may result in increased secondary operation as margin clearance. In addition, our result is concordant with those of the study by Baek et al. [22] where HER2 overexpression was shown to cause ...

The ball size distribution used was 75 to 200 mm and the rock size .. The other mills, as previously mentioned ball mills have a very low efficiency in terms of utilizing the energy generated towards particle size reduction.The diameter of the balls used in ball mills play a significant role in the improvement and optimization of the efficiency of the mill [4].The optimum rotation speed of a mill, which is the .. The population balance model (PBM) is a strategy that has been widely used for modeling the rate of change of particle size distribution in materials subjected to comminution processes [90,247,230 .. The process of particle size reduction by grinding is inherently inefficient and involves high capital and operating costs.In particular, ball milling is one of the important unit operations in .. They are generally used to grind material which is 1/4 inch or smaller, down to a particle size of 20 to 75 microns.For the ball mills to be efficient, the grinding has to be done in a closed ...

States that the energy required for size reduction is proportional to the change in surface area of the pieces of food E K R 1 1 D. p. D. f K. R Rittinger s constant For the size reduction of fine powders, in which large areas of new surface are being created, Rittinger s Law

Learn about the veterinary topic of Overview of Parakeratosis. Find specific details on this topic and related topics from the Merck Vet Manual.

Learn about hammer mills and high pressure homogenizers and how they both work for particle size reduction. Decide which one is the better choice for you.

particle size reduction efficiency was evaluated and compared for the various milling systems, including a hammer mill, attrition mill, pin mill and a turbo mill.

where d b.max is the of feed (mm); σ is compression strength (MPa); E is modulus of elasticity (MPa); ρb is density of material of balls (kg/m 3); D is inner diameter of the body (m).. Generally, a allowed is situated in the range from D /18 to D/24.. The degree of filling the with balls also influences productivity of the and milling efficiency.. ...

Some process need only crushing of the material to meet either to requirement of coarse material or to feed smaller sized material to another grinder. Two hardened rolls rates towards each other. They are kept nearer to each other by means of either mechanical devices or with hydraulic system. This system helps to create the pressure on the rolls and makes the crushing possible. The larger particle of mass, cereals, pulses is pushed between the rolls uniformly spread and with continuous rate through a separate device. A dried feed mass gives material at the bottom with reduced size or if soaked cereals or pulses, give you the material in a flake form. Due to use of roll, Flakers also known as a roll crusher.. ...

Grain, flour and feed industry news and commentary offering insight on business, new products, market and product trends, supplier innovations and more.

A Grinding Ball Mill is a type of grinder used to grind and blend materials for use in mineral processes A Grinding Ball mill works on the principle of impact and attrition size reduction is done by impact as the balls drop from near the top of the shell. can a ball mill grind to nanosize. Chili 120-150tph Station de concassage mobile de.A ball mill is a type of grinder used to grind and blend bulk material into QDs nanosize using different sized balls. The working principle is simple impact and attrition size reduction take place as the ball drops from near the top of a rotating hollow cylindrical shell. The nanostructure size can be varied by varying the number and size of. ...

Roll Crusher Design Calculation Chapter 4 design of flywheel for jaw crusher 41 flywheel 32 42 role of flywheel in a jaw crusher 32 43 stresses in a flywheel 34 44 design calculations 38 45 design of spring for tension bar 40 46 final results and discussion 41 2015 crushing of coal and calculation of size reduction efficiency 26 size reduction equipment duty feed ...

The RIPTOR® shows its versatility by opening and emptying outer packaging material with an opening rate of > 98% for waste bags and small packages >=3liters.

Versatile cone mill for particle sizing; ideal for size reduction of medium hard -soft, sticky items, commonly used in the food & pharmaceutical industries.

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[randpic] Size Reduction SyStemS Capovani are permitted to pass through the FitzMills screen and exit the machine. Higher rotor speeds flatten the approach angle of a particle relative to a screens surface, effectively reducin

Shredder & Screw press AIO(All In One Machine) is the machine that integrate industrial shredder with dewatering screw press. The all in one design for combining size reduction and solid-liquid separtion in one step without conveying. The shredder & Screw press AIO can be used in the waste-to-energy

sciencehabit writes In a new study, researchers find that a single number that describes the complexity of feather patterns on bird chests, a parameter called the fractal dimension, is linked to whether a bird has a strong immune system or is malnourished. When scientists restricted the food of red...

CANTO FOURTH. Thus they, with freaks of proud delight, Beguile the remnant of the night; And many a snatch of jovial song Regales them as they wind along; While to the music, from on high, The echoes make a glad reply.But the sage Muse the revel heeds No farther than her story needs; Nor will she servilely attend The loitering journey to its end. -Blithe spirits of her own impel The Muse, who scents the morning air, To take of this transported pair A brief and unreproved farewell ; To quit the slow-paced waggons side, And wander down yon hawthorn dell, With murmuring Greta for her guide. - There doth she ken the awful form Of Raven-crag-black as a stormGlimmering through the twilight pale; And Ghimmer-crag, . his tall twin brother, Each peering forth to meet the other :And, while she roves through St. Johns Vale, Along the smooth unpathwayed plain, By sheep-track or through cottage lane, Where no disturbance comes to intrude Upon the pensive solitude, Her unsuspecting eye, perchance, With the ...