Buy CEACAM18 elisa kit, Canine Carcinoembryonic antigen-related cell adhesion molecule 18 (CEACAM18) ELISA Kit-NP_082512.1 (MBS7211769) product datasheet at MyBioSource, ELISA Kits
Ceacam12 (untagged) - Mouse carcinoembryonic antigen-related cell adhesion molecule 12 (Ceacam12), transcript variant 1, (10ug), 10 µg.
Kakunaga S., Ikeda W., Itoh S., Deguchi-Tawarada M., Ohtsuka T., Mizoguchi A., Takai Y.. Nectins are Ca2+-independent immunoglobulin-like cell-cell adhesion molecules and comprise a family of four members. At the mossy fiber terminals of hippocampus, nectin-1 and nectin-3 localize at the presynaptic and postsynaptic sides of synaptic junctions, respectively, and their trans-interactions play a role in formation of synapses in cooperation with N-cadherin. Nectins are associated with the actin cytoskeleton through afadin, a nectin- and actin-filament-binding protein. Five nectin-like molecules (Necls) which have domain structures similar to those of nectins have been identified and here we characterize Necl-1/TSLL1/SynCAM3, from now on referred to as Necl-1. Tissue distribution analysis showed that Necl-1 was specifically expressed in the neural tissue. Immunofluorescence and immunoelectron microscopy revealed that Necl-1 localized at the contact sites among axons, their terminals, and glia cell ...
We describe a high-throughput screening system to detect interactions between leucocyte surface proteins, taking into account that these interactions are usually of very low affinity. The method involves producing the extracellular regions of leucocyte proteins with tags so that they can be bound to nanoparticles to provide an avid reagent to screen over an array of 36 similar proteins immobilized using the Proteon XPR36 with detection by surface plasmon resonance. The system was tested using established interactions that could be detected without spurious binding. The ability to detect new interactions was shown by identifying a new interaction between carcinoembryonic antigen-related cell adhesion molecule 1 and carcinoembryonic antigen-related cell adhesion molecule 8.
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Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994). Enhances netrin-induced phosphorylation of PAK1 and FYN (PubMed:15169762). Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994). Adhesion molecule that promotes lamina-specific ...
A protein encoded by a gene in band 22 of the long arm of human chromosome 21. The gene contains multiple exons which allow multiple mRNAs to be transcribed by alternative splicing (q.v.). The transcripts are differentially expressed in different substructures of the adult brain. The DSCAM is a member of the immunoglobulin domain superfamily (q.v.). These isoforms may be involved in the patterning of neural networks by selective adhesions between axons. See innate immunity. ...
Synaptic cell adhesion molecules (SynCAMs) are crucial for synapse formation and plasticity. However, we have previously demonstrated that SynCAMs are also required during earlier stages of neural circuit formation because SynCAM1 and SynCAM2 (also known as CADM1 and CADM2, respectively) are important for the guidance of post-crossing commissural axons. In contrast to the exclusively homophilic cis-interactions reported by previous studies, our previous in vivo results suggested the existence of heterophilic cis-interactions between SynCAM1 and SynCAM2. Indeed, as we show here, the presence of homophilic and heterophilic cis-interactions modulates the interaction of SynCAMs with trans-binding partners, as observed previously for other immunoglobulin superfamily cell adhesion molecules. These in vitro findings are in agreement with results from in vivo studies, which demonstrate a role for SynCAMs in the formation of sensory neural circuits in the chicken embryo. In the absence of SynCAMs, ...
TY - JOUR. T1 - Surface Marker Epithelial Cell Adhesion Molecule and E-cadherin Facilitate the Identification and Selection of Induced Pluripotent Stem Cells. AU - Chen, Hsin Fu. AU - Chuang, Ching Yu. AU - Lee, Wen Chih. AU - Huang, Hsiang Po. AU - Wu, Han Chung. AU - Ho, Hong Nerng. AU - Chen, Yu Ju. AU - Kuo, Hung Chih. PY - 2011/9/1. Y1 - 2011/9/1. N2 - The derivation of induced pluripotent stem cells (iPSCs) requires not only efficient reprogramming methods, but also reliable markers for identification and purification of iPSCs. Here, we demonstrate that surface markers, epithelial cells adhesion molecule (EpCAM) and epithelial cadherin (E-cadherin) can be used for efficient identification and/or isolation of reprogrammed mouse iPSCs. By viral transduction of Oct4, Sox2, Klf4 and n- or c-Myc into mouse embryonic fibroblasts, we observed that the conventional mouse embryonic stem cell (mESC) markers, alkaline phosphatase (AP) and stage-specific embryonic antigen 1 (SSEA1), were expressed in ...
Background: Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), an immunoglobulin (Ig)-related glycoprotein, serves as cellular receptor for a variety of Gram-negative bacterial pathogens associated with the human mucosa. In particular, Neisseria gonorrhoeae, N. meningitidis, Moraxella catarrhalis, and Haemophilus influenzae possess well-characterized CEACAM1-binding adhesins. CEACAM1 is typically involved in cell-cell attachment, epithelial differentiation, neovascularisation and regulation of T-cell proliferation, and is one of the few CEACAM family members with homologues in different mammalian lineages. However, it is unknown whether bacterial adhesins of human pathogens can recognize CEACAM1 orthologues from other mammals.,br /,Results: Sequence comparisons of the amino-terminal Ig-variable-like domain of CEACAM1 reveal that the highest sequence divergence between human, murine, canine and bovine orthologues is found in the β-strands comprising the bacteria-binding ...
Our previous in vitro data suggested that CEACAM1 is involved in angiogenesis. This is supported by a recent proteomic screen for cell membrane components expressed in newly formed tumor vessels and the fact that CEACAM1 expression is upregulated in synergy with other angiogenic factors in cardiac hypoxia (17, 19). To date, however, evidence for a causal implication of CEACAM1 in angiogenesis in vivo was lacking. In the present study, we report on 2 different genetic mouse models in which the angiogenic action of CEACAM1 has been investigated: in CEACAM1endo+ mice, the expression of CEACAM1-L was targeted to endothelia via the Tie2 promoter, and in Ceacam1-/- mice, the Ceacam1 gene was inactivated by targeted disruption (29). In addition, endothelial cells were transfected with cDNAs coding for WT CEACAM1-L and for CEACAM1-L mutants harboring amino acid substitutions in the cytoplasmic domain. In these experimental systems, we provide conclusive evidence that CEACAM1 is involved in angiogenesis ...
PMID: Gut. 2013 Apr 18. Epub 2013 Apr 18. PMID: 23598352. Abstract Title: Western diet induces dysbiosis with increased E coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation. Abstract: OBJECTIVE: Western diet is a risk factor for Crohns disease (CD). Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is abnormally expressed in CD patients. This allows adherent-invasive Escherichia coli (AIEC) to colonise the gut mucosa and leads to inflammation. We assessed the effects of a high fat/high sugar (HF/HS) Western diet on gut microbiota composition, barrier integrity and susceptibility to infection in transgenic CEABAC10 mice expressing human CEACAMs. DESIGN: Colonic microbiota composition and susceptibility of CEABAC10 mice to AIEC LF82 bacteria infection were determined in mice fed a conventional or HF/HS diet. Barrier function and inflammatory response were assessed by studying intestinal permeability, tight junction protein and mucin expression and ...
Soluble cell adhesion molecules (sCAMs) are a class of cell adhesion molecule (CAMs - cell surface binding proteins) that may represent important biomarkers for inflammatory processes involving activation or damage to cells such as platelets and the endothelium. They include soluble forms of the cell adhesion molecules ICAM-1, VCAM-1, E-selectin and P-selectin (distinguished as sICAM-1, sVCAM-1, sE-selectin and sP-selectin). The cellular expression of CAMs is difficult to assess clinically, but these soluble forms are present in the circulation and may serve as markers for CAMs. Research has focused on their role in cardiovascular (particularly atherosclerosis), connective tissue and neoplastic diseases, where blood plasma levels may be a marker of the disease severity or prognosis, and they may be useful in evaluating progress of some treatments. Many studies have postulated that increased production of cell adhesion molecules (CAMs) on the vascular endothelium (blood vessel lining) plays a ...
Cell and matrix adhesion of lymphocytes participates in homing, migration and accumulation of these cells in inflamed tissues as well as in the generation of immune and inflammatory responses. In inflamed joints of rheumatoid arthritis (RA) patients, lymphocytes accumulate in the synovial membrane and the synovial fluid. In the present study we have analyzed the expression of integrins and other adhesion molecules in synovial fluid lymphocytes (RA-SFL) and paired peripheral blood lymphocytes (RA-PBL) from 21 RA patients by immunofluorescence flow cytometry. We have also investigated the expression of these adhesion molecules on peripheral blood lymphocytes obtained from 13 sex- and age-matched healthy controls (CO-PBL). RA-SFL, which consisted mostly of T cells, showed higher expression of the integrin subunits beta 1 (CD29), VLA-1 alpha, -3 alpha, -4 alpha, -5 alpha and -6 alpha when compared to RA-PBL. In turn, RA-PBL showed lower expression of these molecules than CO-PBL. The expression of the
Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein mediating Ca2+-independent homotypic cell-cell adhesion in epithelia. EpCAM is also involved in cell signaling, migration, proliferation, and differentiation. Additionally, EpCAM has oncogenic potential via its capacity to upregulate c-myc, e-fabp, and cyclins A & E. Since EpCAM is expressed exclusively in epithelia and epithelial-derived neoplasms, EpCAM can be used as diagnostic marker for various cancers. It appears to play a role in tumorigenesis and metastasis of carcinomas, so it can also act as a potential prognostic marker and as a potential target for immunotherapeutic strategies. First discovered in 1979, EpCAM was initially described as a dominant surface antigen on human colon carcinoma. Because of its prevalence on many carcinomas, it has been "discovered" many different times. EpCAM therefore has many aliases the most notable of which include TACSTD1 (tumor-associated calcium signal transducer 1), CD326 ...
Down Syndrome Cell Adhesion Molecules (dscam and dscaml1) are essential regulators of neural circuit assembly, but their roles in vertebrate neural circuit function are still mostly unexplored. We investigated the functional consequences of dscaml1 deficiency in the larval zebrafish (sexually undifferentiated) oculomotor system, where behavior, circuit function, and neuronal activity can be precisely quantified. Genetic perturbation of dscaml1 resulted in deficits in retinal patterning and light adaptation, consistent with its known roles in mammals. Oculomotor analyses revealed specific deficits related to the dscaml1 mutation, including severe fatigue during gaze stabilization, reduced saccade amplitude and velocity in the light, greater disconjugacy, and impaired fixation. Two-photon calcium imaging of abducens neurons in control and dscaml1 mutant animals confirmed deficits in saccade-command signals (indicative of an impairment in the saccadic premotor pathway), while abducens activation by ...
Recombinant Human Epithelial cell adhesion molecule(EPCAM),partial von Cusabio bei SZABO-SCANDIC erhältlich. Weiteres zu Proteine & Peptide finden Sie hier.
Recombinant Human Epithelial cell adhesion molecule(EPCAM),partial von Cusabio bei SZABO-SCANDIC erhältlich. Weiteres zu Proteine & Peptide finden Sie hier.
cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA contains a PF00059 domain.. cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA contains a PF00084 domain.. cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA contains a PF00084 domain.. cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA contains a PF00008 domain.. cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA is proteolytically cut by matrix metallopeptidase-3 (M10.005) cleavage... cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA is proteolytically cut by matrix metallopeptidase-1 (M10.001) cleavage... cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA is proteolytically cut by ADAM17 peptidase (M12.217) cleavage. KLDK-SFSM.. ...
In brain, signaling mediated by cell adhesion molecules defines the identity and functional properties of synapses. The specificity of presynaptic and postsynaptic interactions that is presumably mediated by cell adhesion molecules suggests that there exists a logic that could explain neuronal connectivity at the molecular level. Despite its importance, however, the nature of such logic is poorly understood, and even basic parameters, such as the number, identity, and single-cell expression profiles of candidate synaptic cell adhesion molecules, are not known. Here, we devised a comprehensive list of genes involved in cell adhesion, and used single-cell RNA sequencing (RNAseq) to analyze their expression in electrophysiologically defined interneurons and projection neurons. We compared the cell type-specific expression of these genes with that of genes involved in transmembrane ion conductances (i.e., channels), exocytosis, and rho/rac signaling, which regulates the actin cytoskeleton. Using these data,
TY - JOUR. T1 - Role of cellular adhesion molecules in HIV type 1 infection and their impact on virus neutralization. AU - Hioe, C. E.. AU - Bastiani, L.. AU - Hildreth, James. AU - Zolla-Pazner, S.. PY - 1998. Y1 - 1998. N2 - While CD4 and several chemokine receptors are the principal receptors for human immunodeficiency virus type 1 (HIV-1) viruses, other cell membrane proteins also play a role in HIV-1 infection. A large array of host cell- derived membrane proteins, including adhesion molecules, are incorporated into the envelope of HIV-1 virions, and the profile of host cell proteins acquired by the virus depends on the cells used to propagate the virus. The major leukocyte adhesion molecules, such as leukocyte-function associated antigen-1 (LFA-1), intercellular adhesion molecule-1 (ICAM-1), and CD44, retain their biological functions when expressed on the virion surface, and have been shown to increase virus-cell interaction, enhance virus infectivity, and extend the host cell range of ...
Cell adhesion molecules are cell surface glycoproteins, the function of which is regulated by neurons at different stages of brain development and in response to a variety of external stimuli, for example during learning.. This project will aim to identify and characterise new endogenous regulators of cell adhesion molecules and test artificial regulators of cell adhesion molecules to analyse their pharmacological potential in various disease models.Recombinant protein production, mass spectrometry, protein-protein interaction assays, various protein analysis tools, and cellular models will be used.. ...
Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here. ...
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Cell adhesion molecules play an important role in the development of several chronic fibroproliferative diseases such as glomerulosclerosis, cirrhosis, pulmonary fibrosis, and atherosclerosis.7 The infiltration of monocytes and T lymphocytes, which initiates the atherosclerotic process, is mediated by adhesion receptors. Once they have entered the vascular wall, leucocytes release a variety of cytokines and other bioactive molecules. This results in the proliferation and migration of smooth muscle cells and subsequently promotes the deposition of excess connective tissue.8 These actions are primarily regulated by β1 integrins, although VCAM-1 is also expressed strongly on the surface of activated smooth muscle cells and may help to retain leucocytes within atherosclerotic vessels.9 The αvβ3 integrin has been demonstrated in atherosclerotic plaques10 and may be a therapeutic target that, if blocked, could prevent the formation of new vessels-reducing plaque growth and the migration of smooth ...
The CD56 antigen is a 140 kDa isoform of the Neural Cell Adhesion Molecule (N-CAM). Post-translational modifications to the polypeptide include N- and O- glycosylations, acylation, sulphation and phosphorylation. The different N-CAM isoforms have molecular weights ranging from 135 to 220 kDa. The CD56 antigen is moderately expressed on a subpopulation of peripheral blood large granular lymphocytes and on all cells with NK activity. It is also expressed by subsets of T lymphocytes. CD56 antibodies do not react with granulocytes, monocytes or B cells.
Read Cell Adhesion Molecules Cellular Recognition Mechanisms by with Rakuten Kobo. The Fourth Annual Pezcoller Symposium entitled Adhesion Molecules: Cellular Recognition Mechanisms was held in Rovereto,...
Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell-cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes ...
The cell-cell adhesion molecule 1 (C-CAM1) plays an important role as a tumor suppressor for prostate cancer. Decreased expression of C-CAM1 was detected in prostate, breast, and colon carcinoma. Reexpression of C-CAM1 in prostate and breast cancer cell lines was able to suppress tumorigenicity in vivo. These observations suggest that C-CAM1 may be used as a marker for cancer detection or diagnosis. To generate monoclonal antibodies specific to C-CAM1, we have overexpressed full-length human C-CAM1 in Sf9 cells using a baculovirus expression system. The protein was purified 104-fold using nickel affinity chromatography. About 0.4 mg purified C-CAM1 was obtained from 200 mg of infected cells. When the purified protein was digested with peptidyl-N-glycosidase, the apparent mobility of the protein on SDS-PAGE changed from 90 to 58 kDa, which is close to the molecular weight predicted from the cloned cDNA sequence. This observation suggests that C-CAM1 was glycosylated on asparagine residues when expressed
The mechanism by which low affinity adhesion molecules function to produce stable cell-cell adhesion is unknown. In solution, the interaction of human CD2 with its ligand CD58 is of low affinity (500 mM-1) and the interaction of rat CD2 with its ligand CD48 is of still lower affinity (40 mM-1). At the molecular level, however, the two systems are likely to be topologically identical. Fluorescently labeled glycosylphosphatidylinositol-anchored CD48 and CD58 were prepared and incorporated into supported phospholipid bilayers, in which the ligands were capable of free lateral diffusion. Quantitative fluorescence imaging was used to study the binding of cell surface human and rat CD2 molecules to the fluorescent ligands in contact areas between Jurkat cells and the bilayers. These studies provide two major conclusions. First, CD2/ligand interactions cooperate to align membranes with nanometer precision leading to a physiologically effective two-dimensional affinity. This process does not require the intact
Background: To analyze the expression of Metadherin (MTDH), Carcinoembryonic Antigen related Cell adhesion Molecule 1 (CEACAM1) and Hepatitis B virus ..
Top performende anti-Ratte (Rattus) Metadherin Antikörper für Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) vergleichen & kaufen.
The IUPHAR/BPS Guide to Pharmacology. PVR cell adhesion molecule - Immunoglobulin like domain containing proteins. Detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of drug targets.
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Elucidation of the role of ectoenzymes in leukocyte extravasation has opened new possibilities to design antiinflammatory drugs. As the catalytic centers of enzymes are often easily accessible to analogues of known substrates and inhibitors and the crystal structures of many enzymes are resolved, ecto-enzymes are optimal targets for rational drug design. Furthermore, small molecule enzyme inhibitors can often be administered orally. This is a clear benefit in comparison to antibodies against other adhesion molecules (eg, natalizumab and efalizumab), which need to be injected intravenously or subcutaneously.76,77. Silencing of VAP-1 appears to be desirable for antiinflammatory purposes. Several animal models with antibodies and inhibitors have demonstrated the potential of VAP-1 as a drug target (see above). Importantly, the first clinical Phase I/IIa trials with a prototype murine monoclonal antibody against human VAP-1 have shown that VAP-1 can be targeted safely.29 Further clinical trials with ...
Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.
How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, gene organization? Are you tired of scanning review articles, primary papers and databases to locate that elusive fact? The new Academic Press FactsBook series will satisfy scientists and clinical researchers suffering from information overload. Each volume provides a catalogue of the essential properties of families of molecules. Gene organization, amino acid sequences, physiochemical properties, and biological activity are presented using a common, easy to follow format. Taken together they compile everything you wanted to know about proteins but were too busy to look for. The Adhesion Molecule FactsBookcontains over 50 entries on all currently cloned and characterized cell adhesion molecules, including the families of * integrins * cadherins * selectins * members of the immunoglobulin superfamily * and other relevant receptors Provides ...
Epithelial cell adhesion molecule (EpCAM) is highly expressed in advanced epithelial cancers and tumor-initiated cells (TICs), but its roles in cancer progression remain to be elucidated. Here, we showed that the extracellular domain of EpCAM (EpEX) could bind to EGFR through EGF-like domain I, and subsequently activated its downstream molecules, ERK1/2 and Akt. EGFR inhibitor and knockdown of EGFR by shRNA ablated EpEX-induced ERK1/2 phosphorylation. Regulated intramembrane proteolysis (RIP) of EpCAM was induced similarly by EpEX and EGF through EGFR-dependent activation of ERK pathway. MEK inhibitor, U0126, could abolish ADAM17 and PS2 phosphorylation induced by EpEX. EpAb2-6, an anti-EpEX neutralizing monoclonal antibody, inhibits EpEX-activated EGFR-PI3K-AKT pathway in detached colon cancer cells. Moreover, intracellular domain of EpCAM (EpICD), the product of RIP-induced cleavage of EpCAM, is necessary for nuclear accumulation of β-catenin, and their target gene expressions in vitro and in ...
Cell adhesion molecule (CADM) genes encode immunoglobulin superfamily molecules, which are involved in cell‑cell adhesion in a number of human epithelia. Through the maintenance of epithelia, CADM genes protect against malignant conversion and metastasis. Whilst numerous in vitro studies have investigated the molecular characteristics of CADM1 and CADM4 and in vivo studies have investigated CADM1 and CADM4 expression in a number of tumor types, the roles of CADM1 and CADM4 have yet to be elucidated. Therefore, in the present study, CADM1 and CADM4 expression levels were evaluated using immunohistochemistry staining in 208 patients with breast cancer and compared with clinicopathological factors. CADM1 and CADM4 expression levels were negative in 160 (76.9%) and 166 (79.8%) of the 208 cases, respectively. The lack of expression in these cases was associated with advanced tumor stage, suggesting that inactivation of CADM1 and CADM4 promotes breast cancer development. The prognostic role of CADM1 ...
Adhesion molecules in atherosclerosis.Adhesion molecules, ICAM-1, ICAM-1 and atherosclerosis, Circulating ICAM-1 in coronary artery disease
Broekema M, Harmsen MC, Koerts JA, van Kooten TG, Navis G, van Luyn MJ, and Popa ER. (2007). Tubular engraftment and myofibroblast differentiation of recipient-derived cells after experimental kidney transplantation. Transplantation 84: 1003-11. PubMed. Broekema M, Harmsen MC, van Luyn MJ, Koerts JA, Petersen AH, van Kooten TG, van GH, Navis G, and Popa ER. (2007). Bone marrow-derived myofibroblasts contribute to the renal interstitial myofibroblast population and produce procollagen I after ischemia/reperfusion in rats. J Am Soc Nephrol 18: 165-75. PubMed. Kosterink JG, McLaughlin PM, Lub-de Hooge MN, Hendrikse HH, van ZJ, van GE, Harmsen MC, and de Leij LF. (2007). Biodistribution studies of epithelial cell adhesion molecule (EpCAM)-directed monoclonal antibodies in the EpCAM-transgenic mouse tumor model. J Immunol 179: 1362-8. PubMed. Krenning G, Dankers PY, Jovanovic D, van Luyn MJ, and Harmsen MC. (2007). Efficient differentiation of CD14+ monocytic cells into endothelial cells on ...
Bonds between adhesion molecules are often mechanically stressed. A striking example is the tensile force applied to selectin-ligand bonds, which mediate the tethering and rolling of flowing leukocytes on vascular surfaces(1-3). It has been suggested ...
Goat polyclonal Cell adhesion molecule 4 antibody validated for WB, ELISA, IHC and tested in Human. Immunogen corresponding to synthetic peptide
The pathogenesis of glaucoma apparently involves the same cell adhesion molecule that is implicated in the development of vascular diseases. Scientists have discovered that the "endothelial leucocyte cell adhesion molecule 1" (ELAM-1) is present in the eyes of patients with glaucoma but not in healthy eyes. This is the first known molecular marker for glaucoma and may lead to an early genetic screening test (Nature Medicine 2001;7:304-9).. Dr … ...
Principal Investigator:MASUDA Michitaka, Project Period (FY):1998 - 1999, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Experimental pathology
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Gene target information for ESAM - endothelial cell adhesion molecule (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.