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Ceftriaxone therapy of chronic inflammatory arthritis. A double-blind placebo controlled trial. Arch Intern Med. 1990 Aug;150(8):1677-82.. In a placebo-controlled, double-blind study of 60 patients with inflammatory arthritis - rheumatoid arthritis (RA), psoriatic arthritis (PsA), vasculitis, and undifferentiated connective tissue disease (UCTD) - who were positive for Lyme disease (borrelia burgdorferi), patients were randomized to be in one of two study arms to either receive an inactive placebo or the antibiotic, ceftriaxone, 2 grams/day, intravenously for 2 weeks. Nearly half of the antibiotic group (19/40 patients) experienced improvement as compared with the placebo group (2/20 patients), who were later able to elect to receive ceftriaxone therapy. Of 58 patients who were treated with IV ceftriaxone, 27 were notably improved at follow-up, 13-24 months later, and responses were seen in all forms of arthritis (RA 5/12, PsA 5/8, vasculitis 3/5, and UCTD 14/33). Of these 27 patients, 16 ...
To determine whether chronic inflammatory arthritis may respond to antibiotic therapy (implying a bacterial origin), we conducted a placebo-controlled, double-blind study. Sixty patients with inflammatory arthritis and antibody titers to Borrelia burgdorferi 1:64 or more were randomized to receive placebo (n = 20) or 2 g/d of ceftriaxone intravenously (n = 40) for 2 weeks. Two of 20 placebo- and 19 of 40 antibiotic-treated patients improved. At 1 month, the placebo-treated patients could elect to receive ceftriaxone. Altogether, 58 patients were treated with ceftriaxone and followed up for 13 to 24 months. Improvement was noted in 27 of the 58 antibiotic-treated patients. Patients with a wide diversity of inflammatory arthritis were studied. Response to ceftriaxone was seen in all groups, including 5 of 12 with rheumatoid arthritis, 5 of 8 with psoriatic arthritis, 3 of 5 with vasculitis, and 14 of 33 with less well-differentiated chronic inflammatory arthritis. In 16 of the 27 who responded to the
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RICHARDS, G A et al. A comparison of the pharmacokinetics of Aspen Ceftriaxone and Rocephin in community-acquired meningitis. SAMJ, S. Afr. med. j. [online]. 2013, vol.103, n.12, pp.906-909. ISSN 2078-5135.. BACKGROUND: Community-acquired bacterial meningitis (CABM) is a life-threatening condition that is common among immunocompromised individuals. Intravenous ceftriaxone, of which Rocephin (ROC) is the originator brand, is recommended as first-line therapy in South Africa. Despite concerns regarding therapeutic equivalence with generic agents, this is the first study that has been conducted comparing clinical pharmacokinetics (PK) of a generic ceftriaxone formulation with the originator. OBJECTIVE: To compare the PK and safety of Aspen Ceftriaxone (AC) and ROC in the treatment of adult CABM. METHODS: A total of 63 eligible patients were randomised 1:1 to receive 2 g of either medication twice daily for a duration based on the identity of the causative organism and their physicians clinical ...
Lyme disease, now the most common tick-borne illness in the United States, has recently received much media attention, due in part to its potentially serious sequelae in untreated patients. Because a rare patient with late illness may lack antibodies to the etiologic agent, Borrelia burgdorferi, physicians may be tempted to give empiric antibiotics for illnesses that may not be Lyme disease. We have described a patient who, despite negative laboratory evidence for late Lyme disease, was treated for 3 weeks with intravenous ceftriaxone and sustained serious complications, including granulocytopenia, fever, hepatitis, and Clostridium difficile-associated diarrhea. We caution physicians to weight carefully the risks of empiric treatment for ill-defined medical problems, and to recognize the hazards of even safe medications.
Product Name: Ceftriaxone Sulbactam Injection Common Name: antibiotic injection. Strength: 1.5gm. Description: Ceftriaxone is a broad-spectrum semi-synthetic third-generation cephalosporin with a potent bactericidal activity against a wide range of gram-positive and gram-negative bacteria. Sulbactam is ß- lactamase inhibitor. Ceftriaxone is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Ceftriaxone has activity in the presence of some beta-lactamases, both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria.. Indications and Usage:. Ceftriaxone Injection is used to cure below mentioned infections:. ...
TY - JOUR. T1 - Effects of the excitatory amino acid transporter subtype 2(EAAT-2) inducer ceftriaxone on different pain modalities in rat. AU - Eljaja, Laila. AU - Bjerrum, Ole Jannik. AU - Honoré, Per Gustaf Hartvig. AU - Abrahamsen, Bjarke. PY - 2011. Y1 - 2011. KW - Det tidligere Farmaceutiske Fakultet. U2 - 10.1016/j.sjpain.2011.03.003. DO - 10.1016/j.sjpain.2011.03.003. M3 - Tidsskriftartikel. VL - 2. SP - 132. EP - 136. JO - Scandinavian Journal of Pain. JF - Scandinavian Journal of Pain. SN - 1877-8860. IS - 3. ER - ...
ND = Not determined. Thirty-three percent to 67% of a ceftriaxone dose was excreted in the urine as unchanged drug and the remainder was secreted in the bile and ultimately found in the feces as microbiologically inactive compounds. After a 1 g IV dose, average concentrations of ceftriaxone, determined from 1 to 3 hours after dosing, were 581 mcg/mL in the gallbladder bile, 788 mcg/mL in the common duct bile, 898 mcg/mL in the cystic duct bile, 78.2 mcg/g in the gallbladder wall and 62.1 mcg/mL in the concurrent plasma.. Over a 0.15 to 3 g dose range in healthy adult subjects, the values of elimination half-life ranged from 5.8 to 8.7 hours; apparent volume of distribution from 5.78 to 13.5 L; plasma clearance from 0.58 to 1.45 L/hour; and renal clearance from 0.32 to 0.73 L/hour. Ceftriaxone is reversibly bound to human plasma proteins, and the binding decreased from a value of 95% bound at plasma concentrations of , 25 mcg/mL to a value of 85% bound at 300 mcg/mL. Ceftriaxone crosses the blood ...
Huntingtons disease (HD) is an inherited neurodegenerative disorder characterized by cortico-striatal dysfunction and loss of glutamate uptake. At 7 weeks of age, R6/2 mice, which model an aggressive form of juvenile HD, show a glutamate-uptake deficit in striatum that can be reversed by treatment with ceftriaxone, a β-lactam antibiotic that increases GLT1 expression. Only at advanced ages (| 11 weeks), however, do R6/2 mice show an actual loss of striatal GLT1. Here, we tested whether ceftriaxone can reverse the decline in GLT1 expression that occurs in older R6/2s. Western blots were used to assess GLT1 expression in both striatum and cerebral cortex in R6/2 and corresponding wild-type (WT) mice at 9 and 13 weeks of age. Mice were euthanized for immunoblotting 24 hr after five consecutive days of once daily injections (ip) of ceftriaxone (200 mg/kg) or saline vehicle. Despite a significant GLT1 reduction in saline-treated R6/2 mice relative to WT at 13, but not 9, weeks of age, ceftriaxone treatment
Ceftriaxone Sodium for Injection (by Teva): Ceftriaxone belongs to the family of antibiotics known as cephalosporins. It is used to prevent or treat certain infections caused by bacteria. It is given by injection only into a muscle or vein.
It is known that nerve cells called motor neurons die in the brains and spinal cords of people with amyotrophic lateral sclerosis (ALS). However, the cause of this cell death is unknown. Researchers think that increased levels of a chemical called glutamate may be related to the cell death. For this reason researchers want to study drugs that decrease glutamate levels near nerves. Ceftriaxone-a semi-synthetic, third generation cephalosporin antibiotic-may increase the level of a protein that decreases glutamate levels near nerves. Studies of ceftriaxone in the laboratory suggest that it may protect motor neurons from injury.. Ceftriaxone is approved by the U.S. Food and Drug Administration (FDA) for treating bacterial infections but not for treating ALS. Also, ceftriaxone has not been given to people over a long period of time, such as months or years. The goals of this study are to evaluate the safety and effectiveness of ceftriaxone as a treatment for ALS, and to determine the safety and ...
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The only disclosure restriction on the PI is that the sponsor can review results communications prior to public release and can embargo communications regarding trial results for a period that is more than 60 days but less than or equal to 180 days. The sponsor cannot require changes to the communication and cannot extend the embargo ...
Odicef-T from Galpha, Ceftriaxone - Axone-SB to Cadizone | Ceftriaxone is a third-generation cephalosporin antibiotic. Use of Odicef-T from Galpha, Pregnancy, lactation in childrens and special precautions for Odicef-T from Galpha, prices of Odicef-T from Galpha . Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to cefotaxime in terms of safety and efficacy.Ceftriaxone is often used (in combination, but not direct, with macrolide and/or aminoglycoside antibiotics) for the treatment of community-acquired or mild to moderate health care-associated pneumonia. It is also a choice drug for treatment of bacterial meningitis. In pediatrics, it is commonly used in febrile infants between 4 and 8 weeks of age who are admitted to the hospital to exclude sepsis. The dosage for acute ear infection in the very young is 50 mg/Kg IM, one dose only. It has also been used in the treatment of Lyme
BACKGROUND. Community-acquired pneumonia (CAP) is a major cause of death and morbidity worldwide. Treatment is centred on antibiotics with ceftriaxone and amoxicillin-clavulanate being some of the most commonly prescribed agents. Objective. To compare treatment outcomes and costs in patients receiving either of these two antibiotics at Witbank Hospital (WH). METHODS. A total of 200 randomly selected adult patient files (100 receiving ceftriaxone and 100 amoxicillin-clavulanate) recording a diagnosis of CAP were studied to determine the length of hospital stay, comorbid conditions and treatment outcomes. A descriptive and comparable analysis was performed. RESULTS. Male gender, higher CURB-65 scores and death were associated with the use of ceftriaxone. Severity of disease and previous antibiotic exposure influenced the duration of hospital admission. CONCLUSION. Gender and severity of disease (based on the CURB-65 score) were the determinants of antibiotic choice at WH. Male gender increased the ...
LOWMAN, Warren et al. Comparative MIC evaluation of a generic ceftriaxone by broth microdilution on clinically relevant isolates from an academic hospital complex in South Africa. SAMJ, S. Afr. med. j. [online]. 2012, vol.102, n.2, pp.102-103. ISSN 2078-5135.. We evaluated the in vitro microbiological efficacy of a generic ceftriaxone product against several clinically significant organisms collected from sterile sites. The minimum inhibitory concentration (MIC) of each was determined simultaneously with the reference and the generic ceftriaxone product. Comparative analysis of MICs between the two products for each isolate was performed using both categorical (interpretive) agreement and essential (actual MIC value) agreement. A total of 260 isolates were tested. Overall, there was categorical agreement of 98.9% and essential agreement of 95.8%. The categorical agreement for all isolates (96.7 - 100%) accorded with international standards, as no very major errors were seen and the major error ...
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FIG. 1. Time-kill curves for B. spielmanii isolate PC-Eq17 with ceftriaxone. Lines in boldface indicate borrelial growth of the growth control (GC), inoculum reduction at the MIC (0.031 μg/ml), and killing of the inoculum at the MBC (2 μg/ml) over 120 h of incubation. For reasons of comparison, lines not in boldface show borrelial growth at a ceftriaxone concentration of the MIC (0.008 μg/ml) and decelerated killing of the inoculum at a concentration of 3 log10 units below the MBC (0.25 μg/ml). Experiments were performed on different days by investigation of growth using conventional cell counts, and data are reported as the means from two independent experiments. ...
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In hospitalized neonates and infants suffering from severe infectious disease; the use of injectable antibiotics is essential. Co-amoxiclav and Ceftriaxone injection are among the widely used antibiot-ics in children due to their relative safety and wide spectrum of activity. Since doses depend on the nature of the disease, age and weight of the patient, in most neonates and infants only a part of the reconstituted solution or suspension is used for a single dose due to their relatively low weights. The remaining part of the preparation is usually discarded by virtue of unreliability in its stability, increasing the cost of the treatment on patients and health institutes. This study aims to investigate the effect ofintensity of temperature and light (indoor light) on the stability of reconstituted Co-amoxiclav and Ceftriaxone injectable solutions in order to use them in the most cost-effective manner. The room temperature adopted in this study was 30°C instead of the 25°C used by the ...
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Ceftriaxone containing medications, Ceftriaxone indications and usages ATC and ICD codes, combinations with other active ingredients and trade names information from Drugs-about.com
CEFTRIAXONE KABI 1 Ginj / inf lahuse pulber 1g N5; N10 Pakendi infoleht: teave patsiendile Ceftriaxone Kabi 1 g, süste- või infusioonilahuse pulber
Ceftriaxone - A remedy or mode of treatment, placed in antithesis to the radical, C'ara radlca'lis; PALM, Palma, Vola, V.
Rocephin is a cephalosporin antibiotic used to treat different type of bacterial infection and severe condition like meningitis. Correct coding of rocephin shot injection can increase medical reimbursement . Its needed at least three codes : Supplies Administration Code E/M Codes Supplies: J0696 Rocephin Injection, Ceftriaxone Sodium, Per 250 mg HCPCS code J0696…
Surgical Procedure. Before the administration of thiopentone sodium (general anesthetic agent), each dog from all four groups was pre-medicated by administering atropine-sulphate @ 0.045 mg/ Kg body weight through subcutaneous (S/C) route, half an hour prior to surgical intervention to minimize secretions of the salivary glands and respiratory tract (Plumb, 2008). Thiopentone sodium was administered by the slow vein puncture of cephalic vein, at a dose rate of 25 mg/ Kg body weight. Then laprotomy procedure was performed by following adequate pre-operative measures. Each dog was positioned as 300 tilted to the horizon in the dorsal recumbency and umbilicus was considered as surgical landmark. Ventral midline incision of about 12 cm length was made through the skin and subcutaneous tissue with the help of scalpel blade. Then peritoneal cavity was opened carefully by a stab incision and the falciform ligament was resected with scissors. This permitted uniform peritoneal contact at the closure, and ...
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In case the nearby resistance prices are higher than ten%, a dose of intravenous ceftriaxone normally is prescribed. Individuals with far more extreme symptoms are sometimes admitted a healthcare facility for ongoing antibiotics.[29] If indications tend not to enhance following two or 3 times of cure, it can necessarily mean that the urinary tract is blocked by a kidney stone.[two][29 ...
Antibacterials, Cephalosporins, Third generation cephalosporins, Acute bacterial otitis media ( Rocephin ); treatment of infections of lower respiratory tract, skin and skin structures, bone and joint, and urinary tract; treatment of pelvic inflammatory disease, intra-abdominal infections, gonorrhea ( Rocephin ), meningitis, and septicemia caused by susceptible microorganisms; preoperative prophylaxis. Unlabeled Uses Neurologic complications, arthritis, and carditis associated with Lyme disease in patients refractory to penicillin G.
Results 223 hospitals were identified as having acute paediatric units, from which 170 (76%) responses were received. First-line antibiotic is closely split between ceftriaxone (82 units; 48%) and cefotaxime (76 units; 45%). 96 (52%) units using ceftriaxone as first line (exclusively or as either cefotaxime or ceftriaxone) have no exceptions for using it in guidelines. Few units using ceftriaxone caution specifically about concomitant calcium use (14%) or its use in younger infants (12%). Although the vast majority of units perceived that their guidelines were adhered with 84 (49%) saying always and 81 (48%) saying mostly, only 61 (36%) had conducted an audit. ...
In amyotrophic lateral sclerosis, down-regulation of the astrocyte-specific glutamate excitatory amino acid transporter 2 is hypothesized to increase extracellular glutamate, thereby leading to excitotoxic motor neuron death. The antibiotic ceftriaxone was recently reported to induce excitatory amin …
Marketed under the brand name Rocephin, Ceftriaxone is a cephalosporin antibiotic used to treat infections throughout the body as well as before surgery to prevent infection.
Ceftriaxone has undergone substantial changes which are live in digital versions and will appear in print in BNF for Children 2016-2017 and BNF 72. These changes reflect the updated Summary of Product Characteristics (SPC) for Rocephin® and also advice and feedback from expert opinion and the BNF formulary committees. Indication and dose Indications and doses […]
ConclusionResults confirm that NLC structure is an appropriate alternative for the delivery of ceftriaxone drug with a controlled release behavior....
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First-line treatment for gonorrhea is ceftriaxone plus either azithromycin or doxycycline. In this study, antimicrobial susceptibility testing was done on more than 34 000 urethral isolates from U.S. men with symptomatic gonococcal urethritis. Isolates of Neisseria gonorrhoeae from men who have sex with men were significantly more likely than isolates from men who have sex exclusively with women to exhibit elevated cephalosporin minimal inhibitory concentrations and antimicrobial resistance. This testing is not usually done in routine practice, but clinicians should actively follow men who have sex with men after first-line treatment for gonorrhea for possible treatment failure. ...
Ceftriaxone pharmacokinetics by a sensitive and simple LC-MS/MS method: Development and application. J Pharm Biomed Anal. 2020 Jul 21;189:113484 Authors: Herrera-Hidalgo L, Gil-Navarro MV, Dilly ...
3) Split of code. Combinations of ceftriaxone and other substances remain in QJ01DD54 while combinations of ceftriaxone and beta-lactamase inhibitors are moved to QJ01DD63 ceftriaxone and beta-lactamase ...
Within a matter of weeks, three cases of gonorrhoea that are resistant to the recommended first line antibiotic treatment have been detected in Europe and Australia. These are the first global reports of Neisseria gonorrhoeae with high-level resistance to azithromycin and ceftriaxone resistance that also show resistance to several other vital antibiotics. At a time with limited alternatives to the current dual therapy, lack of a vaccine and insufficient surveillance capacity in some regions, these cases highlight the growing threat of drug-resistance - which could lead to untreatable gonorrhoea. ...