TY - JOUR. T1 - High-pressure liquid chromatographic assay of cefotaxime and desacetylcefotaxime in human myometrium. AU - Bawdon, R. E.. AU - Novick, W. J.. AU - Hemsell, D. L.. AU - Welch, W. D.. PY - 1984. Y1 - 1984. N2 - An analytic high-pressure liquid chromatographic (HPLC) procedure for the assay of desacetylcefotaxime and cefotaxime in gynecologic tissue was developed. Normal individuals undergoing elective hysterectomy were subjects in this study. Blood and myometrium were removed up to four hours after a l-g intramuscular dose of cefotaxime. Since cefotaxime is unstable in homogenized tissue at room temperature, the specimens must be maintained at 4 degree C during homogenization and extraction. Mean serum desacetylcefotaxime and cefotaxime levels were 3. 2 plus or minus 2. 0 mu g/ml and 6. 8 plus or minus 4. 4 mu g/ml, respectively. The mean myometrium concentrations of desacetylcefotaxime and cefotaxime were 8. 4 plus or minus 10. 0 mu g/g and 6. 3 plus or minus 8. 9 mu g/g, ...
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Four ceftazidime-resistant Escherichia coli strains were isolated from elderly nursing home patients in a New York hospital during 1993. Strains MCQ-2, MCQ-3, and MCQ-4 were determined to be identical by pulsed-field gel electrophoresis and plasmid profiles, whereas strain MCQ-1 was unique. Strain MCQ-1 was determined to produce a TEM-10 beta-lactamase. Strains MCQ-2, MCQ-3, and MCQ-4 were also noted to be resistant to cefotaxime. These three strains produced two beta-lactamases with pIs of 5.4 (TEM-1) and 7.6. beta-Lactamase assays revealed that the pI 7.6 enzyme hydrolyzed cefotaxime faster (at a relative hydrolysis rate of 30% compared with that of benzylpenicillin) than either ceftazidime or aztreonam (relative hydrolysis rates of 13 and 3.3%, respectively). Nucleotide sequencing of the gene encoding the pI 7.6 beta-lactamase from strain MCQ-3 revealed a blaSHV-type gene differing from the gene encoding SHV-1 at four nucleotides which resulted in amino acid substitutions: phenylalanine for ...
This randomised prospective non-blinded study compared the pharmacokinetics, pharmacodynamics, antibiotic resistance and clinical efficacy of continuous vs intermittent administration of cefotaxime in 93 patients with chronic obstructive pulmonary disease (COPD) requiring hospitalisation for moderate to severe community acquired exacerbations (GOLD stages 2-4). Forty-seven patients received 2 g of cefotaxime as a continuous infusion over 24 h plus a loading dose of 1 g, while 46 patients received the drug intermittently (1 g three times daily). The mean duration of treatment was 10 days.. The most commonly isolated pathogens were Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis. Clinical cure was achieved in 37/40 (93%) with continuous infusion and 40/43 (93%) with intermittent administration (p = 0.93). No patients in the continuous group had antibiotic concentrations lower than minimal inhibitory concentration (MIC) compared with 40% in the intermittent group. Samples ...
Cefodizime Sodium is the sodium alkali anatomy of cefodizime, a third-generation, aminothiazolyl cephalosporin for parenteral use. Cefodizime has broad-spectrum activity and is abiding to a lot of beta-lactamases. Cefodizime Sodium for bang is Whitish or anemic bare apparent powder. Cefodizime sodium is a broad-spectrum, third bearing cephalosporin. It is awful aggressive to a ample spectrum…
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Clonal Spread of Cefotaxime-Resistant (CTX-R) Salmonella typhimurium in Belarus: Epidemiology and Molecular Analysis of Resistance Mechanisms
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By preventing bacteria from making cell walls, cefotaxime can treat or prevent certain bacterial infections. This eMedTV resource contains information on cefotaxime, including how this antibiotic works, potential side effects, and safety precautions.
4. In patients with severe renal dysfunction, dosage of cefotaxime should be decreased accordingly. In patients with serum creatinine clearance greater than 424μmol/L (4.8mg) or renal corpuscle filtration less than 20ml/minute, half the maintenance dose of cefotaxime is recommended. If serum creatinine clearance greater than 751μmol/L (8.5mg), 1/4 of the maintenance dose of the drug is recommended. In patients undergoing hemodialysis, ...
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Cefotaxime is approved for adults and children who have infections caused by certain types of bacteria. This eMedTV page focuses on specific uses for cefotaxime. It also explores some of the reasons a doctor may prescribe the drug for unapproved purposes.
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The report generally describes cefotaxime sodium(sterile), examines its uses, production methods, patents. Cefotaxime Sodium(Sterile) market situation
Recently, several reports have described ESBLs that do not belong to either the TEM or the SHV family and that are more active against cefotaxime than ceftazidime but that are inhibited by clavulanic acid (3, 5-7, 13-15, 20, 29, 34, 36, 42, 48, 51). They are more closely related to the chromosomal β-lactamase of Klebsiella oxytoca than to the TEM or the SHV β-lactamases (5). These cefotaxime-hydrolyzing β-lactamases include the CTX-M and Toho families, of which four subgroups have been recognized on the basis of amino acid sequence homology (6). The first subgroup, the CTX-M-1 subgroup, includes CTX-M-1 (MEN-1) from E. coli in France (5) and Germany (3), CTX-M-3 from C. freundii and E. coli in Poland (15) and from E. coli in Taiwan (51), and CTX-M-10 from E. coli in Spain (34). The second subgroup is represented by CTX-M-2 and includes CTX-M-2 from Salmonella enterica serovar Typhimurium, E. coli, and Proteus mirabilis in Argentina and from K. pneumoniae in Israel and Paraguay (3); Toho-1 ...
Antimicrobial resistance is an increasing problem in Neisseria gonorrhoeae (NG) treatment. Presently, third-generation parenteral cephalosporins, like ceftriaxone and cefotaxime, are the first option. Resistance to oral, but not to parenteral, third-generation cephalosporins has been reported previously. We analysed the microbial susceptibility (as minimum inhibitory concentration - MIC) of NG cultures obtained from high-risk visitors of the largest Dutch outpatient clinic for sexually transmitted infections (STI) in Amsterdam, the Netherlands. Among 1,596 visitors, we identified 102 patients with at least one NG isolate with reduced susceptibility to cefotaxime (0.125 μg/ml < MIC ≤ 0.5 μg/ml). The percentage of NG isolates with reduced susceptibility to cefotaxime rose from 4.8% in 2006 to 12.1% in 2008 (chi2 17.5, p<0.001). With multivariate logistic regression, being a man who has sex with men (MSM) was significantly associated with reduced susceptibility to cefotaxime (p<0.001).
Cefotaxime is a member of the cephalosporin antibiotic class of drugs that has a rather wide spectrum of activity and is useful as a pre-surgery antibiotic.
38 medications are known to interact with cefotaxime. Includes Acetylsalicylic Acid (aspirin), Augmentin (amoxicillin/clavulanate), B Complex 100 (multivitamin).
Mode of action and Anti-microbial spectrum: Cefotaxime is an inhibitor of bacterial cell wall synthesis. High activity against gram-negative bacteria. Very often used for the elimination of Agrobacterium species after inoculation. High resistance against B-lactamase activity. Nontoxic to plant cells.. ...
Learn about the potential side effects of cefotaxime. Includes common and rare side effects information for consumers and healthcare professionals.
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This medicine is injected into a muscle, or infused through a vein. It is usually given by a health care professional in a hospital or clinic setting.. If you get this medicine at home, you will be taught how to prepare and give this medicine. Use exactly as directed. Take your medicine at regular intervals. Do not take your medicine more often than directed.. It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.. ...
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Provides information on usage, precautions, side effects and brand names when available. Data provided by various government agencies and health-related organizations. ...
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One strain of Escherichia coli and two strains ofKlebsiella pneumoniae that had high levels of resistance to cefotaxime were isolated from the blood of patients in Seoul National University Childrens Hospital in 1995 and 1996. One strain ofShigella sonnei isolated from a pediatric patient on Cheju Island in 2000 also had a high level of cefotaxime resistance. By disk susceptibility testing, the strains were resistant to amoxicillin, cephalothin, and cefotaxime but were susceptible to ceftazidime, cefoxitin, and amoxicillin-clavulanic acid. Isoelectric focusing showed that the four strains produced a β-lactamase with an isoelectric point (pI) of 8.0. PCR with SHV-specific primers (3) was negative for all strains. Cefotaxime resistance was transferred by conjugation (9) from K. pneumoniaestrain 95151 along with a plasmid of 160 kb to E. coli J53 Azir (met proazide resistant) to produce E. coli J53 Azir/pMG267. The β-lactamase gene was cloned from plasmid pMG267 with EcoRI as an 8-kb insert into ...
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TY - JOUR. T1 - Ciprofloxacin - Resistant typhoid with incomplete response to cefotaxime. AU - Adhikari, M. R.Prabha. AU - Baliga, Srikala. PY - 2002/3. Y1 - 2002/3. UR - http://www.scopus.com/inward/record.url?scp=0036512711&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0036512711&partnerID=8YFLogxK. M3 - Article. C2 - 11924574. AN - SCOPUS:0036512711. VL - 50. SP - 428. EP - 429. JO - The Journal of the Association of Physicians of India. JF - The Journal of the Association of Physicians of India. SN - 0004-5772. IS - 3. ER - ...
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casSAR Dugability of O69395 | bla | Beta-lactamase Toho-2 - Also known as BLT2_ECOLX, bla. Hydrolyzes beta-lactam antibiotics such as penicillin G, carbenicillin, cephaloridine, cefoxitin, cefotaxime, ceftazidime, and aztreonam. Has especially increased relative hydrolysis rates for cephalothin, cephaloridine, cefotaxime and ceftizoxime.
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Renal failure commonly develops in the setting of SBP, and its development is a sensitive predictor of in-hospital mortality. The renal impairment is thought to stem from decreased effective arterial blood volume secondary to the systemic inflammatory response to the infection. In our current practice, there are certain circumstances in which we administer albumin early in the SBP disease course in order to reduce the risk of renal failure and mortality. Ultimately, our current protocol originated from the 1999 study of albumin in SBP by Sort et al.. The trial enrolled adults with SBP and randomized them to treatment with either cefotaxime and albumin infusion 1.5 gm/kg within 6hrs of enrollment, followed by 1 gm/kg on day 3 or cefotaxime alone. The primary outcome was the development of "renal impairment" (a "nonreversible" increase in BUN or Cr by more than 50% to a value greater than 30 mg/dL or 1.5 mg/dL, respectively) during hospitalization. The secondary outcome was in-hospital ...
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Product Number , 78097775. CAS Number , 75738-58-8. EC , Molecular Formula , C16H18ClN9O5S3. Molecular Weight , 548.02. Storage Temp , Harmonized Tariff code , 29419000. Signal Word , ...
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Cefixime. Indications. Cefixime is a cephalosporin antibacterial indicated in the treatment of adults and pediatric patients six months of age or older with the following infections when caused by susceptible isolates of the designated bacteria ...
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Multiplicity for the transport of organic anions across the bile canalicular membrane was studied in vivo and in vitro using dibromosulfophthalein (DBSP), [14C]cefodizime, [3H]leukotriene C4 (LTC4) and indocyanine green (ICG) as model compounds in rats. A high concentration of DBSP in plasma reduced the biliary excretion of cefodizime and leukotriene radioactivity to about 15 and 35% of their control values, respectively, but did not affect the excretion of ICG. A high plasma concentration of ICG reduced the excretion of cefodizime to about 60% of the control value, but exerted minimal effect on the excretion of leukotriene radio-activity and DBSP. In vitro, ATP-dependent uptake of LTC4 into the canalicular membrane vesicles was reduced by DBSP, cefodizime and ICG in a dose-dependent manner, with approximate IC50 values of 0.1 microM, 10 microM, and 1 microM, respectively. The hepatic unbound concentration of DBSP sufficient to reduce the excretion of cefodizime, leukotriene radioactivity and ...
Participants may benefit from early antibiotic treatment. The antibiotic cefotaxime has already been confirmed to be safe and effective for the treatment of severe sepsis and is not under scrutiny in this study. Cefotaxime is widely used, generally well tolerated, and is the locally approved broad-spectrum antibiotic for the treatment of sepsis in Cardiff and Vale University Health Board. It is given to patients on admission to hospital as part of standard care. The more common side effects include diarrhoea, nausea, or abdominal discomfort, and are usually mild and temporary. Rarely observed side effects include allergic reactions, with the potential for anaphylaxis (a severe allergic reaction). Treatment of anaphylactic reactions is routine for paramedics, who have access to adrenaline and salbutamol for treating symptoms. Therefore the potential benefits of early use of cefotaxime by paramedics far outweigh the risks of an anaphylactic reaction. Participants who agree to follow up at 90 days ...
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