Abstract: We present three distinct examples where phaseless auxiliary-field Quantum Monte Carlo (ph-AFQMC) can be reliably performed with a single-determinant trial wavefunction with essential symmetry breaking. We first utilized essential time-reversal symmetry breaking with ph-AFQMC to compute the triplet-singlet energy gap in the TS12 set. We found statistically better performance of ph-AFQMC with complex-restricted orbitals than with spin-unrestricted orbitals. We then showed the utilization of essential spin symmetry breaking when computing the single-triplet gap of a known biradicaloid, C$_{36}$. ph-AFQMC with spin-unrestricted Hartree-Fock (ph-AFQMC+UHF) fails catastrophically even with spin-projection and predicts no biradicaloid character. With approximate Br{u}ckner orbitals obtained from regularized orbital-optimized second-order M{\o}ller-Plesset perturbation theory ($\kappa$-OOMP2), ph-AFQMC quantitatively captures strong biradicaloid character of C$_{36}$. Lastly, we applied ...
Winters MJ, Pryciak PM. Interaction with the SH3 domain protein Bem1 regulates signaling by the Saccharomyces cerevisiae p21-activated kinase Ste20. Mol Cell Biol. 2005 Mar; 25(6):2177-90 ...
The Higgs mechanism provides masses to vector bosons, but it does not completely break gauge symmetry (rather, it breaks the global part of it). This is obvious from the fact that gauge symmetry is often used to "eliminate" Goldstone bosons. In fact, Ive read on some other posts that at the quantum level, gauge symmetry is not a considered a symmetry (in the sense that it is not a symmetry of observables), but rather that it is some structural redundancy that physical theories have. Indeed, gauge symmetry breaking is a name more appropriate to the act of adding a gauge fixing term to the lagrangian. I have also read that it is a do-nothing transformation, in the sense that it acts trivially on states. Can someone show me an heuristic calculation showing that a gauge transformation is a do-nothing transformation (by this I mean define some gauge transformation on states and show that the state which is obtained is exactly the one we started from)? ...
Heterotrimeric guanosine triphosphate (GTP)-binding proteins (G proteins) determine tissue and cell polarity in a variety of organisms. In yeast, cells orient polarized growth toward the mating partner along a pheromone gradient by a mechanism that requires Far1p and Cdc24p. Far1p bound Gβγ and interacted with polarity establishment proteins, which organize the actin cytoskeleton. Cells containing mutated Far1p unable to bind Gβγ or polarity establishment proteins were defective for orienting growth toward their mating partner. In response to pheromones, Far1p moves from the nucleus to the cytoplasm. Thus, Far1p functions as an adaptor that recruits polarity establishment proteins to the site of extracellular signaling marked by Gβγ to polarize assembly of the cytoskeleton in a morphogenetic gradient. ...
Some characteristic features of band structures, like the band degeneracy at high symmetry points or the existence of energy gaps, usually reflect the symmetry of the crystal or, more precisely, the symmetry of the wave vector group at the relevant points of the Brillouin zone. In this paper, we will illustrate this property by considering two-dimensional (2D)-hexagonal lattices characterized by a possible two-fold degenerate band at the K points with a linear dispersion (Dirac points). By combining scanning tunneling spectroscopy and angle-resolved photoemission, we study the electronic properties of a similar system: the Ag/Cu(111) interface reconstruction characterized by a hexagonal superlattice, and we show that the gap opening at the K points of the Brillouin zone of the reconstructed cell is due to the symmetry breaking of the wave vector group.
Abstract: In the extra U(1) superstring inspired model, we examine the electroweak and U(1)-prime symmetry breaking with the singlet and exotic quark D, D+{\c}along with the study of heavy Z-prime boson in accordance with the top quark mass region. For this, we have done the analysis of complete renormalization group equations (RGEs)pertaining to the anomaly free E-{\6}-Eta model of rank 5. The Z-prime is found to the order of TeV or above with allowed small Z-Zprime mixing angle, for which the large singlet VEV is required. This is done by considering the only non-universality of Yukawa couplings at GUT scale because these do not obey the E-{\6}relationship and also satisfies the unitarity constraints both at GUT and weak scale, where rest of the parameters, i.e., gaugino masses, tri-linear couplings, and soft supersymmetric breaking masses are kept universal at GUT scale with the gauge couplings unification. The large value of Yukawa couplings (order of 1) triggered the symmetry breaking ...
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PURPOSE: To investigate the efficiency of antiplatelet (aspirin) therapy in vasculogenic erectile dysfunction (VED) patients with a high mean platelet volume. METHODS: A total of 184 patients diagnosed with VED between the ages of 18 and 76 were randomly divided into two groups and treated for 6 weeks [group 1: 120 patients (mean age 48.3), aspirin 100 mg/day; group 2: 64 patients (mean age 47.7), placebo 100 mg/day]. The changes from baseline to end point in erectile function scores on the International Index of Erectile Function (IIEF-EF) and the number of patients who answered "yes" to questions 2 and 3 of the sexual encounter profile (SEP) were compared statistically ...
In Saccharomyces cerevisiae, the Rho-type GTPase Cdc42 regulates polarized growth through its effectors, including the p21-activated kinases (PAKs) Ste20, Cla4, and Skm1. Previously, we demonstrated that Ste20 interacts with several proteins involved in sterol synthesis that are crucial for cell polarization. Under anaerobic conditions, sterols cannot be synthesized and need to be imported into cells. Here, we show that Ste20, Cla4, and Skm1 form a complex with Sut1, a transcriptional regulator that promotes sterol uptake. All three PAKs can translocate into the nucleus and down-regulate the expression of genes involved in sterol uptake, including the Sut1 targets AUS1 and DAN1 by a novel mechanism. Consistently, deletion of either STE20, CLA4, or SKM1 results in an increased sterol influx and PAK overexpression inhibits sterol uptake. For Ste20, we demonstrate that the down-regulation of gene expression requires nuclear localization and kinase activity of Ste20. Furthermore, the Ste20
We have developed a protocol to generate aggregates of mouse embryonic stem cells that display self-organization, symmetry breaking and ...
Casimir is a a joint graduate school between Leiden University and Delft University of Technology with focus on applied and fundamental physics. Casimir organizes courses for PhD students and also has a pre-phd track for MSc. students.
We have studied chiral symmetry breaking in the melt crystallization of 1,1-binaphthyl. We confirm that chiral symmetry breaking can be induced by stirring the melt as it crystallizes. We find an additional process of vapor crystallization to occur alongside the melt crystallization. This complicates the analysis of the enantiomorphism by introducing a further phenomenon: that of polymorphism. Crystallographic studies by X-ray diffraction reveal two polymorphs of 1,1-binaphthyl that are made up of two different conformers of each of the two enantiomeric forms of the molecule. Crystals from the melt are generally chiral tetragonal crystals (P42121) composed of (R)- or (S)-1,1-binaphthyl in a transoid conformer, while those from the vapor are racemic monoclinic crystals (C2/c) made up of the cisoid conformer of both (R)- and (S)-1,1-binaphthyl enantiomers. The main intermolecular interactions in all these crystals are weak aromatic CH/π hydrogen bonds, which are responsible for the ...
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In immunolocalization experiments, we previously had shown that Cdc42p was not observed around the plasma or internal membranes and was only variably seen at the mother-bud neck region (43). The disparity between these patterns and GFP-Cdc42p targeting patterns described herein may be due to the nature of the anti-Cdc42p antibody used. The antibody was raised against a peptide sequence containing amino acids 165 to 181, a region adjacent to the membrane-targeting domain (42) and likely to be in close proximity to the plasma membrane, raising the possibility that steric hindrance interfered with efficient binding. An underestimation of Cdc42p membrane targeting may also be due to the immunolocalization protocol used, including the use of cell wall-digesting enzymes and sodium dodecyl sulfate, required for efficient Cdc42p visualization. These possibilities were supported by the observation that the GFP-Cdc42p immunolocalization pattern with anti-Cdc42p antibody was similar to that seen previously ...
We have studied the ultrafast changes of electronic states in bulk ZnO upon intense hard x-ray excitation from a free electron laser. By monitoring the transient anisotropy induced in an optical probe beam, we observe a delayed breaking of the initial c-plane symmetry of the crystal that lasts for several picoseconds. Interaction with the intense x-ray pulses modifies the electronic state filling in a manner inconsistent with a simple increase in electronic temperature. These results may indicate a way to use intense ultrashort x-ray pulses to investigate high-energy carrier dynamics and to control certain properties of solid-state materials. ...
Lecture 1 - The notions of aquantum phase, order, symmetry breaking. Evolution of quantum systems. The notion of a quantum phase transition, universality, dynamical ctitical exponent, types of phase transitions and level crossing ...
We report results of a search for supersymmetry (SUSY) with gauge-mediated symmetry breaking in di-photon events collected by the DO experiment at the Fermilab Tevatron Collider in 2002-2006. In 1.1 fb(-1) of data, we find no significant excess beyond the background expected from the standard model and set the most stringent lower limits to date for a standard benchmark model on the lightest neutralino and chargino masses of 125 GeV and 229 GeV, respectively, at 95% confidence.. ...
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We just put together our crib! (well.. the babys crib, I guess....) but noticed its dusty and smells like straight up factory! Can I use pinesol or...
Yet she hadnt ever climbed out of her crib, much to our surprise. Until yesterday. I went to get her out in the morning when she began hollering for me and when I walked in the room she said "Paisley do it" as she swung a little leg over the side of the crib. She quickly scaled the wall and dropped to her feet on the other side as I watched in amazement ...
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1.5 Million Graco Strollers have been recalled! The recall includes certain models of strollers and travel systems made by Graco Childrens
This opening lecture lists some of the questions and issues propelling current research in Cell Biology and modelling in this field. I introduce basic features of eukaryotic cells that can crawl, and explain briefly the role of the actin cytoskeleton in cell motility. I also introduce the biochemical signalling that regulates the cytoskeleton and the concept of cell polarization. By simplifying the enormously complex signalling networks, and applying tools of mathematics (nonlinear dynamics, scaling, bifurcations), we can hope to get some understanding of a few of the basic mechanisms that areresponsible for symmetry breaking, robustness, pattern formation, self-assembly, and other cell-level phenomena ...
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Proxicast: Coax Extension Cables For Cellular 3G/4G/LTE & Wi-Fi Applications for Proxicast LAN-Cell and PocketPORT cellular 3G/4G Routers and other 3G routers, 4G routers and LTE routers.
We derive an unbiased information theoretic energy landscape for chromosomes at metaphase using a maximum entropy approach that accurately reproduces the details of the experimentally measured pairwise contact probabilities between genomic loci. Dynamical simulations using this landscape lead to cylindrical, helically twisted structures reflecting liquid crystalline order. These structures are similar to those arising from a generic ideal homogenized chromosome energy landscape. The helical twist can be either right or left handed so chiral symmetry is broken spontaneously. The ideal chromosome landscape when augmented by interactions like those leading to topologically associating domain formation in the interphase chromosome reproduces these behaviors. The phase diagram of this landscape shows that the helical fiber order and the cylindrical shape persist at temperatures above the onset of chiral symmetry breaking, which is limited by the topologically associating domain interaction strength ...
We experimentally demonstrate the realization of a parity-time (PT) symmetry breaking in optically coupled semiconductor lasers (SCLs). The two SCLs are identical except for a detuning between their optical emission frequencies. This detuning is analogous to the gain-loss parameter found in optical PT systems. To model the coupled SCLs, we employ the standard rate equations describing the electric field and carrier inversion of each SCL, and show that, under certain conditions, the rate equations reduce to the canonical, two-site PT- symmetric model. This model captures the global behavior of the laser intensity as the system parameters are varied. Overall, we find that this bulk system (coupled SCLs) provides an excellent test-bed to probe the characteristics of PT-breaking transitions, including the effects of time delay ...
SMSB processes yield a stochastic distribution of chiral signs between successive experiments or outcomes. This means that for a large number of experiments, or in a scenario of a large number of independent working reactors, as in the abiotic scenario of hydrothermal vents in the Hadean Ocean, the average over all the individual stochastic outputs must be the racemic mixture. However, a characteristic of SMSB bifurcations is that a very weak external chiral polarization can select one of the two degenerate chiral branches.20,21 Therefore, any weak chiral induction on the enantiomeric transition states, sufficiently weak so that it has no chemical relevance for common asymmetric synthesis, selects one of the two SMSB bifurcation branches deterministically for one of the two chiral signs. There are recent dramatic experimental examples of this for the Soai reaction.13 Thus, for example Fig. 5 shows a simulation for the deterministic effect of an extremely weak chiral polarization that converts ...
Takahashi T, Muneoka Y, Lohmann J, deHaro LM, Solleder G, Bosch TCG, David CN, Bode HR, Koizumi O, Shimizu H, Hatta M, Fujisawa T, Sugiyama T (1997) Systematic isolation of peptide signal molecules regulating development in hydra: Lwamide and PW families. Proc Natl Acad Sci USA 94:1241-1246.PubMedGoogle Scholar ...
In this thesis, simulations are performed to study the motion ofindividual cells in flow, focusing on the hydrodynamics of actively swimming cells likethe self-propelling microorganisms, and of passively advected objects like the red bloodcells. In particular, we develop numerical tools to address the locomotion ofmicroswimmers in viscoelastic fluids and complex geometries, as well as the motion ofdeformable capsules in micro-fluidic flows.. For the active movement, the squirmer is used as our model microswimmer. The finiteelement method is employed to study the influence of the viscoelasticity of fluid on theperformance of locomotion. A boundary element method is implemented to study swimmingcells inside a tube. For the passive counterpart, the deformable capsule is chosen as the modelcell. An accelerated boundary integral method code is developed to solve thefluid-structure interaction, and a global spectral method is incorporated to handle theevolving cell surface and its corresponding ...
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Emotions are difficult to interpret, particularly if you are existing in an epistemological vacuum where the theory of evolution and the evolutiona of organisms (and their nervous systems) isnt there to serve as an internal referent that allows you to recognize the essential polarity of the organism - that which is generative and symmetrical, and that which is dissipative and symmetry breaking. These terms come from the physics of thermodynamics, and the study of the physics of organisms, where symmetry (generative) dynamics exist side by side with dissipative (disequilibrated) dynamics, generally termed metabolism. In a certain sense, the gene-protein macro-molecular edifice that builds us into a real-physical structure can be considered the symmetry within us, whereas its tendency towards dissolution (heat loss) puts it into constant interaction with small metabolites, co-factors and the environment to keep itself alive ...
Abstract: Five years after their discovery, much of the interest in iron-pnictide materials remains in understanding not only their superconducting transition at nearly 60K, but also the nature of their normal state. In this context, a hotly debated topic is the origin of the tetragonal to orthorhombic transition, which either precedes or happens simultaneously to a magnetic instability, and persists even in the vicinities of the superconducting dome. Experiments have revealed that the anisotropies in this orthorhombic phase cannot be explained by the small lattice distortion alone, suggesting that the tetragonal symmetry breaking is driven by electronic degrees of freedom, dubbed nematic in analogy to the physics of liquid crystals. In this talk, I will present a consistent microscopic theoretical model for this nematic phase and explore its manifestations in a variety of macroscopic properties of the iron pnictides -- such as elastic, magnetic, and transport properties. The model is rooted on ...
The effect of load rate on the load-carrying capabilities of wood cribs is investigated in this Bureau of Mines study. The modulus of deformation (stiffness) of wood crib blocks has been shown to increase with increases in rates of load application, causing larger load reactions for increases in convergence rates. Since wood cribs are tested in the laboratory at convergence rates that are orders
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Your baby will spend a lot of time in the crib, and its your job to make sure its always a safe environment. Heres how to ensure the safety of your littlest sleeper.
MBAM, MSE shutdown, freezing and redirects! Ouch! - posted in Virus, Spyware, Malware Removal: My wifes D600 dell gets a regular scan with MBAM and has MSE ( only Av program) installed. Basics are XP Pro w/ SP3, Firefox, Thunderbird. She started complaining about freezing, sluggishness lately as well as losing emails , etc. Yesterday the MSE shutoff and would not start using the on screen dialog box. I tried to run a scan with MBAM but it wouldnt run either. Trying to go online I...
TY - JOUR. T1 - Genetic control of the cell division cycle in yeast. IV. Genes controlling bud emergence and cytokinesis. AU - Hartwell, Leland. PY - 1971. Y1 - 1971. N2 - Temperature-sensitive mutations in one gene (cdc1) of Saccharomyces cerevisiae confer a defect in bud emergence. Asynchronous cultures of cells defective in cdc1 collect uniformly as unbudded cells (or cells with very tiny buds) following a shift from the permissive to the restrictive temperature. Studies with synchronous cultures demonstrate that the thermolabile product of cdc1 completes its function (the execution point) for bud emergence at the time of bud emergence (0.2 fractions of a cell cycle). When this function is not completed at the restrictive temperature. cells complete DNA replication but do not undergo nuclear division. Temperature-sensitive mutations in four genes (cdc3, 10, 11, and 12) result in a defect in cytokinesis. At the restrictive temperature these mutant strains develop multiple elongated buds that ...
CSHL Press publishes monographs, technical manuals, handbooks, review volumes, conference proceedings, scholarly journals and videotapes. These examine important topics in molecular biology, genetics, development, virology, neurobiology, immunology and cancer biology. Manuscripts for books and for journal publication are invited from scientists world wide.
CSHL Press publishes monographs, technical manuals, handbooks, review volumes, conference proceedings, scholarly journals and videotapes. These examine important topics in molecular biology, genetics, development, virology, neurobiology, immunology and cancer biology. Manuscripts for books and for journal publication are invited from scientists world wide.
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A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is obse…
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Veja abaixo uma selecção dos resultados da ARCOPOL que têm sido especialmente bem vindos pelos utilizadores finais. Por exemplo, esta lista inclui ferramentas que têm sido implementadas por organizações competentes nas suas actividades diárias (visualizadores da ARCOPOL, a Análise de Risco Dinâmico, etc.), ou vídeos, cursos e-learning, e orientações, que estão a ser usados em programas de formação por diferentes entidades ...
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