Cathepsin W is a protein that in humans is encoded by the CTSW gene.[5][6][7]. The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2.[7]. ...

Korpos et al. (1) claim that limited information exists on the nature of the ECM [extracellular matrix] of the pancreas and, in particular, on the composition of peri-islet capsule, and that they provide the the first comprehensive analysis of the [ECM] composition of peri-islet capsules.. We dispute the strength of these claims. In mice we originally reported in 2008 that a basement membrane (BM) exists around islets, and eight unique components were identified (type IV collagens α1, α2, laminin α2, β1, γ1, nidogen 1, nidogen 2, perlecan) as well as two composite components (laminin Engelbreth-Holm-Swarm, collagen IV) (2). It was also shown that type IV collagens α3, α4, α5, α6 were not present (2). Korpos et al. (1) were able to find a further three unique components (laminin α4, β2, agrin) and one composite component (laminin 322).. In 2008 in humans (3,4), at least four unique components (laminin α1, α5, β1, γ1) were identified and in their Supplementary Figure 1 staining ...

Mouse monoclonal Cathepsin W antibody [BV39-2B]. Validated in WB, IHC and tested in Human. Immunogen corresponding to recombinant full length protein.

The task of tracing visual language in book design is a challenge, but one that is useful to take up in order to help us understand how readers make meaning of what they read. Studying the lineage of some forms of layout also sheds light on how design fits into and contributes to culture in a wider sense. Childrens science books - the highly graphic and colourful ones published over the last 30 years or so in the UK - provide some excellent examples of complex visual language, partly because they tend to be more highly illustrated than books meant for adults. But how do diagrams, illustrations and different forms of text interact to produce content in these books? Meaning does not reside in the book alone, but is dependent on context: the particular conditions of reading, and the wider social and cultural environment. This is an exploration of book design as a medium of communication.. Many changes have occurred in British childrens publishing over the past 30 years. These have had a visible ...

TY - JOUR. T1 - Common Features of Patients With Autoimmune Atrophic Gastritis. AU - Miceli, Emanuela. AU - Lenti, Marco Vincenzo. AU - Padula, Donatella. AU - Luinetti, Ombretta. AU - Vattiato, Claudia. AU - Monti, Claudio Maria. AU - Di Stefano, Michele. AU - Corazza, Gino Roberto. PY - 2012/7. Y1 - 2012/7. N2 - Background & Aims: Autoimmune atrophic gastritis (AIG) is characterized by immune-mediated chronic inflammation of the gastric body and fundus, leading to hypo-achlorhydria and vitamin B12 deficiency. We analyzed the clinical features of AIG and sought to identify factors that might be used in diagnosis. Methods: We collected and analyzed clinical data from 99 consecutive patients (age, 59 ± 17 y) who were diagnosed with AIG, based on histologic factors and the presence of autoantibodies against gastric parietal cells. Results: Clinical factors that led to a diagnosis of AIG included hematologic findings related to vitamin B12 deficiency (n = 37), incidental histologic evidence in ...

Autoimmune atrophic gastritis: current perspectives Artem Minalyan,1 Jihane N Benhammou,1 Aida Artashesyan,1 Michael S Lewis,2 Joseph R Pisegna1 1Division of Gastroenterology, Hepatology and Parenteral Nutrition, 2Department of Pathology and Laboratory Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA Abstract: At present there is no universally accepted classification for gastritis. The first successful classification (The Sydney System) that is still commonly used by medical professionals was first introduced by Misiewicz et al in Sydney in 1990. In fact, it was the first detailed classification after the discovery of Helicobacter pylori by Warren and Marshall in 1982. In 1994, the Updated Sydney System was proposed during the International Workshop on the Histopathology of Gastritis followed by the publication in The American Journal of Surgical Pathology by Dixon et al. Using the new classification, distinction between atrophic and nonatrophic gastritis was revised, and the

Author: Pfizer, J. M. et al.; Genre: Journal Article; Published in Print: 2007-06; Keywords: calpain; cathepsin B and L; peptide libraries; trans-epoxysuccinyl-peptides; primed binding subsites; inhibitors; Title: Primed-site probing of papain-like cysteine proteases

Author: Pfizer, J. M. et al.; Genre: Book Chapter; Published in Print: 2005; Title: Primed-site probing of papain-like cysteine proteases

ROZMAN PUNGERČAR, Jerica, KOPITAR-JERALA, Nataša, BOGYO, M., TURK, Dušan, VASILJEVA, Olga, KLEMENČIČ, Ivica, VANDENABEELE, P., BR MME, D., PUIZDAR, Vida, FONOVIĆ, Marko, TRSTENJAK-PREBANDA, Mojca, DOLENC, Iztok, TURK, Vito, TURK, Boris. Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors : when reaction mechanism is more important than specificity. Cell Death Differ, 2003, vol. 10, str. 881-888 ...

Complete information for CTSF gene (Protein Coding), Cathepsin F, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

Causes of Abdominal Tumor. Infection by Helicobacter pylori is believed to be the cause of most abdominal tumor while autoimmune atrophic gastritis, intestinal metaplasia and various genetic factors are associated with increased risk levels. Its also states that diet plays no role in the genesis of abdominal tumor. However, there is some research done listed down the following dietary risks, and protective factors, for abdominal tumor: smoked foods, salted fish and meat, and pickled vegetables (appear to increase the risk of stomach cancer.) Nitrates and nitrites are substances commonly found in cured meats. They can be converted by certain bacteria, such as H. pylori, into compounds that have been found to cause stomach cancer in animals. On the other hand, eating fresh fruits and vegetables that contain antioxidant vitamins (such as A and C) appears to lower the risk of abdominal tumor.. In more detail, H. pylori is the main risk factor in 65-80% of abdominal tumor, but in only 2% of such ...

Causes of Abdominal Tumor. Infection by Helicobacter pylori is believed to be the cause of most abdominal tumor while autoimmune atrophic gastritis, intestinal metaplasia and various genetic factors are associated with increased risk levels. Its also states that diet plays no role in the genesis of abdominal tumor. However, there is some research done listed down the following dietary risks, and protective factors, for abdominal tumor: smoked foods, salted fish and meat, and pickled vegetables (appear to increase the risk of stomach cancer.) Nitrates and nitrites are substances commonly found in cured meats. They can be converted by certain bacteria, such as H. pylori, into compounds that have been found to cause stomach cancer in animals. On the other hand, eating fresh fruits and vegetables that contain antioxidant vitamins (such as A and C) appears to lower the risk of abdominal tumor.. In more detail, H. pylori is the main risk factor in 65-80% of abdominal tumor, but in only 2% of such ...

As highlighted by the similarity of their fold and the superimposition of their active site, we have shown that NsPCS belongs to the papain superfamily of cysteine proteases. It is therefore expected that the peptide hydrolase activity of NsPCS, i.e., the deglycination of GSH, resembles the general and well known mechanism of papain-like cysteine proteases. By analogy with such a mechanism, Cys-70, His-183, and Asp-201 (equivalent to Cys-56, His-162, and Asp-180 in AtPCS1) correspond to the catalytic triad in NsPCS. Moreover, it is also highly probable that Cys-70 and His-183 form a thiolate-imidazolium ion pair, stabilized by Asp-201, and that the nucleophilic attack of Cys-70 on the Cys-Gly peptide bond is favored by the oxyanion hole, made up of Cys-70 and Gln-64. In a second step, the water molecule W153, whose nucleophilicity is enhanced by the proximity of His-183 and Asp-201, is then ideally placed to attack the thioester bond and liberate the γ-glutamylcysteine. We could trap the ...

Fingeravtryck Fördjupa i forskningsämnen för Papain-like cysteine proteinase zone (PCP-zone) and PCP structural catalytic core (PCP-SCC) of enzymes with cysteine proteinase fold. Tillsammans bildar de ett unikt fingeravtryck. ...

The propeptide of cruzipain--a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F