TY - JOUR. T1 - Polymeric catenanes synthesized via click chemistry and atom transfer radical coupling. AU - Bunha, Ajaykumar. AU - Cao, Peng Fei. AU - Mangadlao, Joey. AU - Shi, Fei Mo. AU - Foster, Edward. AU - Pangilinan, Katrina. AU - Advincula, Rigoberto. PY - 2015/5/1. Y1 - 2015/5/1. N2 - A novel route for the synthesis of polymeric catenanes was demonstrated by grafting an alkyne functionalized polymer onto a supramolecularly templated azide terminated ligand followed by ring closure via atom transfer radical coupling (ATRC). The polymeric catenane was characterized via GPC and AFM imaging. This journal is. AB - A novel route for the synthesis of polymeric catenanes was demonstrated by grafting an alkyne functionalized polymer onto a supramolecularly templated azide terminated ligand followed by ring closure via atom transfer radical coupling (ATRC). The polymeric catenane was characterized via GPC and AFM imaging. This journal is. UR - ...
TY - JOUR. T1 - Towards molecular scale mechano-electronic devices:. T2 - porphyrin catenanes. AU - Gunter, Maxwell J.. AU - Johnston, Martin R.. PY - 1992. Y1 - 1992. N2 - Using self-assembly strategies, catenanes consisting of zinc and free base porphyrins with hydroquinol-containing polyether straps of different lengths interlinked with a tetracationic bipyridinium cyclophane have been synthesised.. AB - Using self-assembly strategies, catenanes consisting of zinc and free base porphyrins with hydroquinol-containing polyether straps of different lengths interlinked with a tetracationic bipyridinium cyclophane have been synthesised.. UR - http://www.scopus.com/inward/record.url?scp=37049082995&partnerID=8YFLogxK. U2 - 10.1039/C39920001163. DO - 10.1039/C39920001163. M3 - Article. AN - SCOPUS:37049082995. SP - 1163. EP - 1165. JO - Journal of the Chemical Society, Chemical Communications. JF - Journal of the Chemical Society, Chemical Communications. SN - 0022-4936. IS - 17. ER - ...
A team of researchers affiliated with several institutions in Japan has developed a way to create catenanes and a molecular trefoil knot out of para-connected benzene rings. In their paper published in the journal Science, the group describes their process and possible uses of their results. Jeff Van Raden, and Ramesh Jasti with the University of Oregon, have published a Perspective piece on the work done by the team in the same journal issue. In recent years, carbon-based materials such as graphene, fullerenes and carbon nanotubes have captured the imagination of scientists-such materials have a wide range of unique physical properties that make them useful for certain applications. Graphene, for example, is a zero-gap semiconductor. Scientists have also been looking at ways in which such structures can be formed. In this new effort, the researchers have found a way to get benzene rings to form into two kinds of catenanes, and also a trefoil knot. Catenanes are a type of molecular architecture ...
TY - JOUR. T1 - Predicting knot and catenane type of products of site-specific recombination on twist knot substrates. AU - Valencia, Karin. AU - Buck, Dorothy. N1 - Copyright © 2011 Elsevier Ltd. All rights reserved.. PY - 2011/8/12. Y1 - 2011/8/12. N2 - Site-specific recombination on supercoiled circular DNA molecules can yield a variety of knots and catenanes. Twist knots are some of the most common conformations of these products, and they can act as substrates for further rounds of site-specific recombination. They are also one of the simplest families of knots and catenanes. Yet, our systematic understanding of their implication in DNA and important cellular processes such as site-specific recombination is very limited. Here, we present a topological model of site-specific recombination characterizing all possible products of this reaction on twist knot substrates, extending the previous work of Buck and Flapan. We illustrate how to use our model to examine previously uncharacterized ...
Benzylic amide catenanes are a class of synthetically-accessible interlocked molecular rings which can rotate one through the other depending on the nature of the local environment. The rings contain four phenyl units each and interlocking also affords their packing in novel, highly interacting ways that may lead to unexpected properties thus opening up the possibility of developing new materials. Third harmonic generation in benzylic amide catenane solutions was measured at a wavelength of lambda = 1064 nm, with the fundamental and the harmonic wavelengths in the region of transparency of the material. The thoroughly non resonant value of the hyperpolarisability gamma(-3 omega; omega, omega, omega) was found to be (6.5 +/- 0.7) x 10(-35) esu with a neg ligible imaginary part, in agreement with the value of (6.8 +/- 0.9)x 10(-35) esu calculated from a bond-additivity model of hyperpolarisability. The static second order hyperpolarisability predicted by a Molecular Orbital model was about a ...
The synthesis and anion binding properties of novel halogen-bonding (XB) bis-iodotriazole-pyridinium-containing acyclic and {[}2]catenane anion host systems are described. The XB acyclic receptor displays selectivity for acetate over halides with enhanced anion recognition properties compared to the analogous hydrogen-bonding (HB) acyclic receptor. A reversal in halide selectivity is observed in the XB {[}2]catenane, in comparison to the acyclic XB receptor, due to the interlocked hosts unique three-dimensional binding cavity, and no binding is observed for oxoanions. Notable halide anion association constant values determined for the {[}2]catenane in competitive organicaqueous solvent mixtures demonstrate considerable enhancement of anion recognition as compared to the HB catenane analogue. X-ray crystallographic analysis of a series of halide catenane complexes reveal strong XB interactions in the solid state. These interactions were studied using Cl and Br K-edge X-ray Absorption Spectroscopy ...
The synthesis and anion binding properties of novel halogen-bonding (XB) bis-iodotriazole-pyridinium-containing acyclic and {[}2]catenane anion host systems are described. The XB acyclic receptor displays selectivity for acetate over halides with enhanced anion recognition properties compared to the analogous hydrogen-bonding (HB) acyclic receptor. A reversal in halide selectivity is observed in the XB {[}2]catenane, in comparison to the acyclic XB receptor, due to the interlocked hosts unique three-dimensional binding cavity, and no binding is observed for oxoanions. Notable halide anion association constant values determined for the {[}2]catenane in competitive organicaqueous solvent mixtures demonstrate considerable enhancement of anion recognition as compared to the HB catenane analogue. X-ray crystallographic analysis of a series of halide catenane complexes reveal strong XB interactions in the solid state. These interactions were studied using Cl and Br K-edge X-ray Absorption Spectroscopy ...
Here is another molecule of the year, on a topic close to my heart, the catenane systems 1 and the trefoil knot 2 Such topology is closely inter-twinned with
The synthesis and photophysical properties of small gold nanoparticles (NPs, AuNP-[Ru-PFF]) surface functionalized by 5-substituted-1,10-phenanthroline-ligand based Ru(ii) complexes are described. Luminescence of the grafted and confined Ru(ii) complexes is totally quenched on the gold surface. Nonlinear opt
The discovery of the B-form structure of DNA by Watson and Crick led to an explosion of research on nucleic acids in the fields of biochemistry, biophysics, and genetics. Powerful techniques were developed to reveal a myriad of different structural conformations that change B-DNA as it is transcribed, replicated, and recombined and as sister chromosomes are moved into new daughter cell compartments during cell division. This article links the original discoveries of superhelical structure and molecular topology to non-B form DNA structure and contemporary biochemical and biophysical techniques. The emphasis is on the power of plasmids for studying DNA structure and function. The conditions that trigger the formation of alternative DNA structures such as left-handed Z-DNA, inter- and intra-molecular triplexes, triple-stranded DNA, and linked catenanes and hemicatenanes are explained. The DNA dynamics and topological issues are detailed for stalled replication forks and for torsional and structural
As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. ...
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Cell and Molecular Biology. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Cell and Molecular Biology, Structural Molecular Biology. STRUCTURAL MOLECULAR BIOLOGY. ...
This invention is concerned with removing metals and sulfur from oil, preferably from residual oil, by contact with a novel catalyst. Said catalyst comprises a Group VIII metal and a Group VI metal deposited within an amorphous porous glass support of controlled pore size distribution.
Diffusion ordered spectroscopy (DOSY) NMR experiments have been used to characterize a dynamic combinatorial library of helical strands and grid-type metallosupramolecular architectures. The technique allows the deconvolution of very similar chemical structures differing only by their hydrodynamic radius. Moreover, the occurrence of springlike, extension-contraction conformational motions in helical strands can be revealed as a function of the temperature. ...
Scientists at Nagoya University have succeeded in synthesizing molecular nanocarbons with knots and catenanes by using a novel method in which silicon atoms are used. The epoch-making product of this research will pave the way to the development of new nanocarbon materials with complex geometric structures.
20] Spruell, J. M.†; Coskun, A.†; Friedman, D. C.; Forgan, R. S.; Sarjeant, A. A.; Trabolsi, A.; Fahrenbach, A. C.; Barin, G.; Paxton, W. F.; Dey, S. K.; Olson, M. A.; Benítez, D.; Tkatchouk, E.; Colvin, M. T.; Carmielli, R.; Caldwell, S. T.; Rosair, G. M.; Hewage, S. G.; Duclairoir, F.; Seymour, J. L.; Slawin, A. M. Z.; Goddard III, W. A.; Wasielewski, M. R.; Cooke, G; Stoddart, J. F. Highly Stable TTF Radical Dimers in [3]Catenanes, Nature Chem., 2010, 2, 870-879. pdf ...
On the other hand, for both regular triangular and quadrilateral meshes, we present several examples of interpolatory ternary subdivision schemes with two-ring stencils such that the critical Hölder smoothness exponents of their basis functions do achieve the optimal smoothness upper bound ...
Mixed metallo-porphyrin cages were selected and amplified from dynamic combinatorial libraries (DCLs) by using appropriate templates. The cages are composed of two bisphosphine substituted zinc(II) porphyrins as ligand donors and two rhodium(III) or ruthenium(II) porphyrins as ligand acceptors, and are connected through metal-phosphorus coordination. Ru and Rh porphyrins that display a large structural diversity were employed. The templating was achieved by using 4,4-bpy, 3,3-dimethyl-4,4-bipyridine and benzo[lmn]-3,8-phenanthroline, and acts through zinc-nitrogen coordination. The absolute amount of amplification from the DCLs is strongly dependent on the combination of the Ru/Rh porphyrin and the template; cages with sterically demanding porphyrins can only form with smaller templates. In the case of tert-butyl-substituted TPP (TPP=tetraphenylporphyrin), cages are not formed at all. The formation of the cages is usually complete within 24 h at an ambient temperature; in the case of the cage ...
We have demonstrated that, in Escherichia coli, quinolone antimicrobial agents target topoisomerase IV (topo IV). The inhibition of topo IV becomes apparent only when gyrase is mutated to quinolone resistance. In such mutants, these antibiotics caused accumulation of replication catenanes, which is diagnostic of a loss of topo IV activity. Mutant forms of topo IV provided an additional 10-fold resistance to quinolones and prevented drug-induced catenane accumulation. Drug inhibition of topo IV differs from that of gyrase. (i) Wild-type topo IV is not dominant over the resistant allele. (ii) Inhibition of topo IV leads to only a slow stop in replication. (iii) Inhibition of topo IV is primarily bacteriostatic. These differences may result from topo IV acting behind the replication fork, allowing for repair of drug-induced lesions. We suggest that this and a slightly higher intrinsic resistance of topo IV make it secondary to gyrase as a quinolone target. Our results imply that the quinolone ...
The tyrosine family of recombinases produces two smaller DNA circles when acting on circular DNA harboring two recombination sites in head-to-tail orientation. If the substrate is supercoiled, these circles can be unlinked or form multiply linked catenanes. The topological complexity of the products varies strongly even for similar recombination systems. This dependence has been solved here. Our computer simulation of the synapsis showed that the bend angles, phi, created in isolated recombination sites by protein binding before assembly of the full complex, determine the product topology. To verify the validity of this theoretical finding we measured the values of phi for Cre/loxP and Flp/FRT systems. The measurement was based on cyclization of the protein-bound short DNA fragments in solution. Despite the striking similarity of the synapses for these recombinases, action of Cre on head-to-tail target sites produces mainly unlinked circles, while that of Flp yields multiply linked catenanes. In full
Dynamic combinatorial libraries (DCLs) are excellent benchmark models to study the stimuli-responsiveness of chemical networks. However, increasingly complex systems are difficult to analyze with simple data analysis methods, because many variables and connections must be considered for their full understanding. Here we propose the use of multivariate data analysis methods to bisect the evolution of a complex synthetic dynamic library of pseudopeptidic macrocycles, containing side chains with ch
Ethylene cross-bridged cyclam with two acetate pendant arms, ECB-TE2A, is known to form the most kinetically stable 64Cu complexes. However, its usefulness as a bifunctional chelator is limited because of its harsh radiolabeling conditions. Herein, we report new cross-bridged cyclam chelator for the development of ultrastable 64Cu-radiolabeled bioconjugates. Propylene cross-bridged TE2A (PCB-TE2A) was successfully synthesized in an efficient way. The Cu(II) complex of PCB-TE2A exhibited much higher kinetic stability than ECB-TE2A in acid decomplexation studies, and also showed high resistance to reduction-mediated demetalation. Furthermore, the quantitative radiolabeling of PCB-TE2A with 64Cu was achieved under milder conditions compared to ECB-TE2A. Biodistribution studies strongly indicate that the 64Cu complexes of PCB-TE2A cleared out rapidly from the body with minimum decomplexation. © 2012 American Chemical Society. ...
The crystal structure of the double-stranded DNA bacteriophage HK97 mature empty capsid was determined at 3.6 angstrom resolution. The 660 angstrom diameter icosahedral particle contains 420 subunits with a new fold. The final capsid maturation step is an autocatalytic reaction that creates 420 isopeptide bonds between proteins. Each subunit is joined to two of its neighbors by ligation of the side-chain lysine 169 to asparagine 356. This generates 12 pentameric and 60 hexameric rings of covalently joined subunits that loop through each other, creating protein chainmail: topologically linked protein catenanes arranged with icosahedral symmetry. Catenanes have not been previously observed in proteins and provide a stabilization mechanism for the very thin HK97 capsid. ...
Dynamic combinatorial chemistry utilises reversible reactions to set up a dynamic library of molecules, with the library composition determined by the thermodynamic stability of each library member. Upon addition of a protein template, any library members which bind to the template are stabilised and amplified. Analysis of the library composition enables the identification of molecules which bind to the template protein. The suitability of two enzyme catalysed reactions catalysed by N-acetylneuraminic acid aldolase and subtilisin® Carlsberg was investigated for use in the synthesis of a DCL. A 173 component dynamic combinatorial library was successfully synthesised using these reactions with the resulting library screened against two protein template molecules, wheat germ agglutinin and Div1B. Several methods were investigated for the simplification of DCL analysis including the immobilisation of protein template molecules and the segregation of DCL proteins using semi-permiable membranes, ...
We design and synthesise new molecular materials, and explore how their properties relate to their molecular structures. This is molecular engineering - engineering at the nano-scale. We use non-covalent self-assembly to control the behaviour of organic semiconductors and dyes, for diverse applications. Our core technique is synthesis, but we also do many other types of experiments, from biological testing to solid-state physics. We explore the conformational, electronic and recognition properties of our compounds using a wide range of spectroscopic and analytical techniques, and we collaborate closely with physicists, physical chemists and biologists.. Projects are being pursued in the following areas: (1) Light-harvesting π-conjugated porphyrin arrays; (2) Photoactive molecules as tools for biomedical research; (3) Single-molecule electronic devices; (4) Polyyne rotaxanes and catenanes; (5) Understanding cooperatively and molecular recognition; (6) Luminescent insulated molecular ...
Catenanes, rotaxanes and knots are characterized by their mechanically interlocked architectures. These molecules are of interest to scientists due to their rare and curious presence in nature, difficulty to synthesize, and potential for use in molecular machines. While synthetic organic chemists have made great strides in creating these entangled structures, very few examples exist in protein-based biological macromolecules. Lasso peptides are one of the only naturally occurring examples of a [1]rotaxane structure in protein space. These molecules are ribosomally synthesized and post-translationally modified into their unique threaded fold. Many of these peptides harbor native biological activity and impressive topological stability, and their potential use as a bioactive scaffold has motivated research in the field. While many approaches to engineer these molecules focus on genetic transformation, we show that altering the chemistry/shape of these structures in vitro offers a new route for ...
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A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner (923 aa ...
The test substance is covered by the category approach of methylenediphenyl diisocyanates (MDI). Hence, data of the category substances can be used to cover this endpoint. Yakabe et al (1994) found that for loadings of 400 - 10,000 mg/L, and under heterogeneous conditions, oligomeric MDI had a half-life of ca. 20h at 25°C when the disappearance rate was fitted to a zero-order kinetic model. However the rate constant increased approximately linearly with the nominal concentration of oligomeric MDI for all constituents. For the two-ring constituents the rate constant was found to be 0.5h-1 (i.e. half-life = 1.4 hour) for a loading of 1000 mg/L oligomeric MDI. The findings in the Yakabe et al (1994) study concur with the generally accepted chemistry of hydrolysis of an isocyanate whereby the initially produced carbamate decarboxylates to amine which then reacts very readily with more isocyanate to produce a urea. For a diisocyanate of low solubility such as MDI, the reaction system is usually ...
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TY - JOUR. T1 - Complete Double Epoxidation of Divinylbenzene Using Mn(porphyrin)-Based Porous Organic Polymers. AU - Zhang, Kainan. AU - Farha, Omar K.. AU - Hupp, Joseph T.. AU - Nguyen, Son Binh T.. PY - 2015/8/7. Y1 - 2015/8/7. N2 - A series of porphyrin-based porous organic polymers (PPOPs) were synthesized in excellent yields via the Yamamoto-Ullmann couplings of tetrabromo spirobifluorene with several brominated porphyrin monomers. After isolation and demetalation, the metal-free PPOP can be postsynthetically metalated to form a MnIII-PPOP that is catalytically active toward the selective double-epoxidation of divinylbenzene to divinylbenzene dioxide. (Chemical Equation Presented).. AB - A series of porphyrin-based porous organic polymers (PPOPs) were synthesized in excellent yields via the Yamamoto-Ullmann couplings of tetrabromo spirobifluorene with several brominated porphyrin monomers. After isolation and demetalation, the metal-free PPOP can be postsynthetically metalated to form a ...
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
NTCDI is redox-active, forming stable radical anions near -1.10 V vs. Fc/Fc+.[5] Its ability to accept electrons reflects the presence of an extended conjugated ring system and the electron withdrawing groups (carbonyl centers). NDI is used in supramolecular chemistry owing to its tendency to form charge-transfer complexes with crown ethers, e.g., to give rotaxanes and catenanes. As another consequence of their planar structure and electron-acceptor properties, NDIs intercalate into DNA. It is also suitable for fabrication of soft electronic devices.[6]. ...
Mitochondria are involved either directly or indirectly in oncogenesis and the alteration of metabolism in cancer cells. Cancer cells contain large numbers of abnormal mitochondria and produce large amounts of reactive oxygen species (ROS). Oxidative stress is caused by an imbalance between the production of ROS and the antioxidant capacity of the cell. Several cancer therapies, such as chemotherapeutic drugs and radiation, disrupt mitochondrial homeostasis and release cytochrome c, leading to apoptosome formation, which activates the intrinsic pathway. This is modulated by the extent of mitochondrial oxidative stress. The peroxiredoxin (Prx) system is a cellular defense system against oxidative stress, and mitochondria in cancer cells are known to contain high levels of Prx III. Here, we review accumulating evidence suggesting that mitochondrial oxidative stress is involved in cancer, and discuss the role of the mitochondrial Prx III antioxidant system as a potential target for cancer therapy. We hope
Get this from a library! Synthesis and reactivity of donor-acceptor substituted aminocyclopropanes and aminocyclobutanes. [Florian de Nanteuil] -- This thesis presents a general approach to accessing nitrogen-substituted hetero- and carbocycles. In short, the annulation reactions developed in the thesis make it possible to access ...
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner (897 aa ...
Aromatic donor-acceptor interactions have been utilized by the Iverson group in the development of abiotic molecules, called aedamers, that achieve new folding motifs, intermolecular association in heteroduplexes, and new material properties. These molecules exploit the interaction between the electron-rich 1,5-dialkoxynapthalene (DAN) and electron-deficient 1,4,5,8-naphthalenetetracarboxylic diimide (NDI) units in a face-centered stacking geometry in aqueous solution. This dissertation describes the use of DAN-NDI interactions in the realm of peptides and proteins to expand the scope for applications of this interaction. This work specifically focuses on three areas of aromatic donor-acceptor interactions: achieving protein behavior with abiotic molecules, introducing the interaction into natural peptides, and utilizing the interaction in the intermolecular association of an abiotic molecule and a natural peptide. Chapter 2 refines the model of aggregation of an amphiphilic aedamer, which forms ...
58. X.-H. Xu, X.-G. Fu, L.-Z. Wu, B. Chen, L.-P. Zhang, C.-H. Tung, H.-F. Ji, K. S. Schanze, R.-Q. Zhang, Intramolecular Triplet Energy Transfer in Donor-Acceptor Molecules Linked by Flexible-Rigid Block Bridge , Chem. Eur. J., 2006, 12, 5238-5245. (PDF file ...
ID LACDN_1_PE6 STANDARD; PRT; 823 AA. AC LACDN_1_PE6; E4SUM1; DT 00-JAN-0000 (Rel. 1, Created) DT 00-JAN-0000 (Rel. 2, Last sequence update) DT 00-JAN-0000 (Rel. 3, Last annotation update) DE SubName: Full=DNA gyrase subunit A; (LACDN_1.PE6). GN OrderedLocusNames=LDBND_0006; OS LACTOBACILLUS DELBRUECKII SUBSP. BULGARICUS ND02. OC Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus. OX NCBI_TaxID=767455; RN [0] RP -.; RG -.; RL -.; CC -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS LACDN_1.PE6. CC Lactobacillus delbrueckii subsp. bulgaricus ND02 chromosome, complete CC genome. CC -!- ANNOTATIONS ORIGIN:E4SUM1_LACDN CC -!- FUNCTION: DNA gyrase negatively supercoils closed circular double- CC stranded DNA in an ATP-dependent manner and also catalyzes the CC interconversion of other topological isomers of double-stranded CC DNA rings, including catenanes and knotted rings (By similarity). CC -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining CC of ...
The relationship between autoantibody status and cancer-associated scleroderma was assessed by logistic regression. Scientific evidence and mass media: Investigating the journalistic buy flomax uk intention to represent scientific uncertainty. On-surface self-organization of a robust metal-organic cluster based on copper(I) with chloride and organosulphur ligands. Catenanes: A molecular mechanics analysis of the (C13H26)2 Structure 13-13 bactrim buy online D2. and the Chapel Hill Consensus Conference (CHCC) was updated in 2012, there are currently prednisone buy online no validated diagnostic criteria for systemic vasculitides. De novo hepatitis B virus infection from anti-HBc-positive donors in pediatric living donor liver transplantation.. Risks related to the resorption dapoxetine priligy buy of a glycine-based irrigation solution. The clinical role of somatosensory evoked potential studies: a critical appraisal. We report a new atlastin mutation causing spastic paraplegia in association with ...
The transport mechanism of organic materials is still far away from being well understood and controlled although conducting polymers have been discovered since 1977. It is rare to see conducting polyers possessing high bipolar (p- and n-type) electrical conductivities within a single bulk dop...
The first part of this Lecture will introduce the concept of molecular recognition, overview major forces of molecular self-assembly and cover several important historical milestones of the field such as the recent Nobel Prize in Chemistry 2016. We will cover many textbook examples of self-assembled systems including molecular (crown ethers, cyclodextrine and calixarenes) as well as biological (proteins, DNA) systems and slowly go up in complexity talking about rotaxanes and catenanes as precursors for the topic of molecular machines. Following examples will present self-assembled systems of various dimensionalities: 0D (micelles, fullerenes), 1D (carbon nanotubes), 2D (self-assembled monolayers, Langmuir-Blodgett films, graphene) and 3D (block copolymers, liquid crystals). We will spend much time trying to classify and sort out non-covalent interactions (e.g. van der Waals forces) that are very important in the world of molecular self-assembly. At the end of this first part, we will look at the ...
Transformation of mechanically interlocked molecules (e.g., rotaxanes and catenanes) into nanoscale materials or devices is an important step towards their real applications. In our current work, an azobenzene-modified β-cyclodextrin (β-CD) derivative that can form a self-inclusion complex in aqueous solution was prepared. The self-included β-CD derivative was then functionalized onto a gold nanoparticle (AuNP) surface via a ligand-exchange reaction in aqueous solution, leading to the formation of AuNP-[1]rotaxane hybrids. Corresponding non-self-included β-CD derivative functionalized AuNPs were also developed in a DMF/H2O mixture solution for control experiments. These hybrids were fully characterized by UV-vis and circular dichroism spectroscopies, together with transmission electron microscopy (TEM). The competitive binding behavior of the hybrids with an adamantane dimer was investigated.
Title: Rationally Designed Donor-Acceptor Random Copolymers with OptimizedComplementary Light Absorption for Highly Efficient All-Polymer Solar Cells Author: Sang Woo Kim, Joonhyeong Choi, Thi Thu Trang Bui, Changyeon Lee,Changsoon Cho, Kwangmin Na,
Composed of alternating electron-rich and electron-deficient repeating units in a fused rigid backbone, donor-acceptor conjugated ladder polymers represent a class of promising material candidates possessing a host of intriguing properties. These polymers are challenging to synthesize because of the typically low r Emerging Investigators
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