© 2017 The Authors Health Expectations Published by John Wiley & Sons Ltd Objective: To examine the effect on cardiovascular (CVD) risk factors of interventions to alter consultations between practitioners and patients with type 2 diabetes. Search Strategy: Electronic and manual citation searching to identify relevant randomized controlled trials (RCTs). Inclusion Criteria: RCTs that compared usual care to interventions to alter consultations between practitioners and patients. The population was adults aged over 18 years with type 2 diabetes. Trials were set in primary care. Data extraction and synthesis: We recorded if explicit theory-based interventions were used, how consultations were measured to determine whether interventions had an effect on these and calculated weighted mean differences for CVD risk factors including glycated haemoglobin (HbA 1c ), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C).
Julius S, Kjeldsen SE, Weber M, Brunner HR, Ekman S, Hansson L, Hua T, Laragh J, McInnes GT, Mitchell L, Plat F, Schork A, Smith B, Zanchetti A, VALUE trial group. Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial. Lancet. 2004; 363(9426): 2022-31 ...
Background Cardiovascular disease may be the leading cause of increased mortality for adolescents with advanced kidney disease. cardiovascular mortality. Great opportunity exists to improve outcomes for children with kidney disease by improving reliability of preventive care that may include formal transition programs. Keywords: Cardiovascular disease, transition, quality, chronic kidney disease, kidney transplantation, dialysis Intro Outcomes for children with chronic kidney disease (CKD) and end-stage renal disease (ESRD) have improved with an increasing number surviving well into adulthood.[1C2] Unfortunately, many of these patients have cardiovascular disease (CVD) mortality rates over 1,000 instances that of their age-matched peers and will experience premature death due to CVD in early adulthood.[3C4] This exceedingly high CVD risk is related to a high prevalence of traditional cardiovascular risk factors (CVRFs) that predict CVD in the general population (such as hypertension, ...
Methods and Results-In a double-blind controlled trial, we randomized 4110 stable kidney transplant recipients to a multivitamin that included either a high dose (n=2056) or low dose (n=2054) of folic acid, vitamin B6, and vitamin B12 to determine whether decreasing total homocysteine concentrations reduced the rate of the primary composite arteriosclerotic cardiovascular disease outcome (myocardial infarction, stroke, cardiovascular disease death, resuscitated sudden death, coronary artery or renal artery revascularization, lower-extremity arterial disease, carotid endarterectomy or angioplasty, or abdominal aortic aneurysm repair). Mean follow-up was 4.0 years. Treatment with the high-dose multivitamin reduced homocysteine but did not reduce the rates of the primary outcome (n=547 total events; hazards ratio [95% confidence interval]=0.99 [0.84 to 1.17]), secondary outcomes of all-cause mortality (n=431 deaths; 1.04 [0.86 to 1.26]), or dialysis-dependent kidney failure (n=343 events; 1.15 ...
Background: Mild cognitive impairment is a risk factor for dementia. Midlife cardiovascular disease risk factors such as high blood pressure and smoking have strong relationships to both cognitive impairment and dementia in late life. Intakes of several nutrients including fats and alcohol have been found to contribute to both cardiovascular disease and risk of cognitive impairment. Literature shows that cardiovascular disease risk factors at age 50, predict lifetime risk of both cardiovascular disease and dementia. The aim of this study is to investigate relationships between the intake of fats and alcohol in relation to cognitive impairment, and five-year cardiovascular disease risk (fatal and non-fatal) in 50 year old Cantabrians. The hypotheses for this study are: • That fifty year olds with higher five year cardiovascular disease risk have a higher risk of mild cognitive impairment. • Secondly that fifty year olds who consume the recommended proportions of dietary fats and recommended ...
The goal of this work was to perform an exploratory analysis to establish a framework for mt-PheWAS for investigating the relationship between mtDNA variation and a range of phenotypes. We first employed a polygenic approach to investigate the global effect of mtDNA variation on phenotypic variance for eight cardiovascular-related traits. Given the metabolic trait focus of the nuclear SNP content on the Metabochip and the nature of the selected phenotypes in this study, we expected the polygenic analysis would reveal significant proportion of trait variance explained. However, overall, we observed relatively low PVE for both nuclear and mitochondrial genetic variation. Only a single trait, total cholesterol, reached statistical significance in the polygenic analysis, although T2D approached the statistical significance threshold of p , 0.05. The low PVE may be due, in part, to the targeted nature of the Metabochip which does not contain a genome-wide distribution of SNPs that can be found on ...
TY - JOUR. T1 - Incidence of new cardiovascular events in patients with and without peripheral arterial disease seen in a vascular surgery clinic. AU - Chhabra, Amit. AU - Aronow, Wilbert S.. AU - Ahn, Chul. AU - Duncan, Kurt. AU - Patel, Jay D.. AU - Papolos, Alexander I.. AU - Sateesh, Babu. PY - 2012/1/1. Y1 - 2012/1/1. N2 - Background: To investigate the incidence of death and of new cardiovascular events at long-term follow-up of patients with and without PAD seen in a vascular surgery clinic. Material/Methods: We investigated the incidence of death, new stroke/transient ischemic attack, new myocardial infarction, new coronary revascularization, new carotid endarterectomy, new peripheral arterial disease (PAD) revascularization, or at least one of the above outcomes at long-term follow-up of patients with and without PAD followed in a vascular surgery clinic. Results: At least one of the above outcomes occurred in 259 of 414 patients (63%) with PAD at 33-month follow-up and in 21 of 89 ...
Comparability of total cardiovascular disease risk estimates using laboratory and non-laboratory based assessments in urban-dwelling South Africans: The CRIBSA study
The ASPEN did not find a significant reduction in the primary composite end point comparing 10 mg of atorvastatin with placebo (13.7 and 15.0%). However, a 27% reduction in fatal and nonfatal myocardial infarction, although nonsignificant, is comparable to that found in statin cardiovascular end point trials (19). The result for the primary end point differs from the majority of recent studies showing a significant CHD benefit of treating individuals with type 2 diabetes (13-16), with or without prior CHD. The reasons for this result may relate to the overall study design, the types of subjects recruited, the nature of the primary end point, and the protocol changes required because of changing treatment guidelines.. Equivalent CVD rates in diabetic patients without prior CHD and nondiabetic patients with CHD were reported in at least three observational studies (1-4). However, at least four other studies did not report as high a rate of CHD in diabetic patients without CHD (5-8). Therefore, the ...
Study documents connection between increased levels of these lipids and cancer growth and metastasis; also opens door to new avenue for cancer treatment. December 19, 2011. Boston, Mass. - A group of small molecules called EETs - currently under scrutiny as possible treatment targets for a host of cardiovascular diseases - may also drive the growth and spread of cancer, according to researchers at the Dana-Farber/Childrens Hospital Cancer Center (DF/CHCC) and other institutions. Their findings also raise the possibility that drugs that block EETs could serve as a new avenue for cancer treatment.. This study, led by Dipak Panigrahy, MD, of DF/CHCC and the Vascular Biology Program at Childrens Hospital Boston, appeared online December 19 in the Journal of Clinical Investigation.. EETs (or epoxyeicosatrienoic acids) are small fatty molecules, part of a larger family of lipids normally produced by the endothelial cells that line blood vessels to control inflammation and the response to injury. ...
The aim of the study was to investigate the effects of rosiglitazone and/or exercise training on novel cardiovascular risk factors in patients with type 2 diabetes mellitus. One hundred overweight/obese type 2 diabetes mellitus patients, with inadequ
Introduction: Current calculators to estimate risk of cardiovascular (CV) disease mortality do not include cardiorespiratory fitness (CRF) or physical activity (PA) measures. This is problematic as CRF is an independent risk factor for CV mortality. To address this issue, Wickramasinghe et al. developed a calculator which includes CRF along with other traditional CV risk factors. The purpose of the present study is to determine the effect of aerobic (AER), resistance (RES) or combination (COMB) exercise training on 30-year CV mortality risk in individuals with type 2 diabetes (T2D).. Methods: The present study is an ancillary analysis of the Health Benefits of Aerobic and Resistance Training Study (HART-D). Adults with type 2 diabetes (T2D) (n=196) were randomized to 9 months of AER, RES, COMB exercise training or a control group (CON). Thirty-year CV mortality risk was evaluated by entering each participants sex, age, blood pressure, smoking status, T2D status, cholesterol, and BMI into a risk ...
The Framingham Risk Score is a gender-specific algorithm used to estimate the 10-year cardiovascular risk of an individual. The Framingham Risk Score was first developed based on data obtained from the Framingham Heart Study, to estimate the 10-year risk of developing coronary heart disease. In order to assess the 10-year cardiovascular disease risk, cerebrovascular events, peripheral artery disease and heart failure were subsequently added as disease outcomes for the 2008 Framingham Risk Score, on top of coronary heart disease. The Framingham Risk Score is one of a number of scoring systems used to determine an individuals chances of developing cardiovascular disease. A number of these scoring systems are available online. Cardiovascular risk scoring systems give an estimate of the probability that a person will develop cardiovascular disease within a specified amount of time, usually 10 to 30 years. Because they give an indication of the risk of developing cardiovascular disease, they also ...
Cardiovascular disease remains the leading cause of death in America, with well-established and identifiable risk factors. Modifiable risk factors are the primary driver for first cardiovascular event, and risk factor modification has been a significant driver for reduction of cardiovascular death in certain populations in recent decades.1,2 However, there remains significant opportunity to improve clinician and patient participation in evidence-based screening and preventative care. According to registry-based studies, 40-60% of patients with cardiovascular risk factors are non-adherent to at least one key component of primary prevention.3 Among those with established atherothrombotic disease, up to 90% are taking antiplatelet, lipid-lowering or anti-hypertensive therapy. However, fewer than 50% are fully adherent to all medications with a class 1 indication in secondary prevention, which is associated with marked increase in risk for recurrent events and death.4. The Million Hearts Initiative ...
In order to prevent cardiovascular events, it is essential to effectively manage overall risk of cardiovascular disease. However, despite guideline recommendations to this effect, current management of the major, modifiable cardiovascular risk factors such as hypertension and dyslipidemia is disconnected and patient adherence to therapy is poor. This is particularly important for patients with multiple cardiovascular risk factors, who are often prescribed multiple medications. The JEWEL study program investigated the use of single-pill amlodipine/atorvastatin as a strategy to improve management of these patients. The JEWEL program consisted of two 16-week, international, open-label, multicenter, titration-to-goal studies in patients with hypertension and dyslipidemia. The two studies differed based on country of enrollment and certain tertiary endpoints, but the overall designs were very similar. Patients were enrolled from 255 centers across Canada and 13 European countries. The study was designed to
Recent studies in the field demonstrate an increasing impact of cardiovascular disease (CVD) on morbidity and mortality in HIV relative to AIDS-related diagnoses. Studies continue to support an approximately 1.5 to two-fold increased risk of IHD conferred by HIV, with specific risk varying by sex and virologic/immunologic status. Risk factors include both traditional CVD risk factors and novel, HIV-specific factors including inflammation and immune activation. Specific antiretroviral therapy (ART) drugs may increase CVD risk, yet the net effect of ART with viral suppression is beneficial with regard to CVD risk. Management of cardiovascular risk and prevention of CVD is complex, because current general population strategies target traditional CVD risk factors only. Extensive investigation is being directed at developing tailored CVD risk prediction algorithms and interventions to reduce CVD risk in HIV.. SUMMARY ...
Cardiovascular disease is a major health concern affecting over 80,000,000 people in the U.S. alone. Heart failure, cardiomyopathy, heart rhythm disorders, atherosclerosis and aneurysm formation have significant heritable contribution. Supported by familial aggregation and twin studies, these cardiovascular diseases are influenced by genetic variation. Family-based linkage studies and population-based genome-wide association studies (GWAS) have each identified genes and variants important for the pathogenesis of cardiovascular disease. The advent of next generation sequencing has ushered in a new era in the genetic diagnosis of cardiovascular disease, and this is especially evident when considering cardiomyopathy, a leading cause of heart failure. Cardiomyopathy is a genetically heterogeneous disorder characterized by morphologically abnormal heart with abnormal function. Genetic testing for cardiomyopathy employs gene panels, and these panels assess more than 50 genes simultaneously. Despite the large
Results Modelbase indicated that baseline age, smoking, hypertension, high low-density lipoprotein cholesterol (LDL-C), low high-density lipoprotein cholesterol (HDL-C), and diabetes were all significantly associated with plaque progression; the summarised population attributable risk (PAR) was 28.4%. Modelbase + change indicated that status changes in age, hypertension, and high LDL-C were significant; the summarised PAR was 37.9%. Compared with Modelbase, Modelbase + change exhibited a significant increase in c-statistics (P = 0.001), from 0.668 (95% CI: 0.645-0.691) to 0.688 (95%CI: 0.665-0.710). The NRI was 2.17% (95% CI: 1.29-3.05, P = 0.073) among participants without atherosclerosis progression, and was 6.57% (95% CI: 5.04-8.11, P , 0.001) among those with progression. The summarised NRI was 8.74 (95% CI: 7.51-9.94, P , 0.001). Adverse change in hypertension and elevated LDL-C accelerated atherosclerosis progression, but favourable change in their status failed to slow progression. We ...
Our analysis demonstrates a complex relationship between 10-year total CVD and CVD mortality in the EPIC-Norfolk prospective population study, a large European cohort. Men and women showed a decreasing CVD morbidity/mortality ratio with increasing age, and with a greater ratio for women in all age groups. Thus, our results suggest that the ratios of total CVD/CVD mortality are age-dependent and sex-dependent. Furthermore, only 12.9% of first CVD events were fatal. By focusing on CVD mortality only, the overall burden of CVD is seriously underestimated, leaving large numbers of individuals untreated, despite the fact that their risk of CVD events is substantial.. The ESC prevention guidelines use the 10-year cardiovascular mortality risk predictor SCORE as a decision-making tool in primary prevention.2 ,8 Using SCORE risk charts, clinicians can identify individuals with a high risk (≥5%) of 10-year CVD mortality. Based on data from the FINRISK study, it is suggested that at the level at which ...
TY - JOUR. T1 - Polyunsaturated fatty acids (PUFAs) levels in patients with cardiovascular diseases (CVDs) with and without depression. AU - Chang, Jane Pei Chen. AU - Chang, Shih Sheng. AU - Yang, Hui Ting. AU - Palani, Mahalakshmi. AU - Chen, Chun Ping. AU - Su, Kuan Pin. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Background: Cardiovascular diseases (CVDs) are commonly comorbid with depression and vice versa. Polyunsaturated fatty acids (PUFAs) have been suggested to mediate in CVDs and depression in cross-sectional and observational studies. With the patients of CVDs, we investigated the role of depression on the effect of PUFAs. Methods: Forty-four patients with CVDs were recruited and assessed with Hamilton depression rating scale (HAMD). Patients CVDs markers were measured by electrocardiogram and their red blood cell (RBC) samples were collected for PUFAs analyses. Results: The data of 44 subjects were analyzed; where 10 participants (23%) with CVDs had moderate or severe depression, defined by ...
Altenburg, Teatske M., Rotteveel, Joost, Dunstan, David W., Salmon, Jo and Chinapaw, Mai J. M. 2013, The effect of interrupting prolonged sitting time with short, hourly, moderate-intensity cycling bouts on cardiometabolic risk factors in healthy, young adults, Journal of applied physiology, vol. 115, no. 12, pp. 1751-1756, doi: 10.1152/japplphysiol.00662.2013. ...
BACKGROUND: The relationship between macronutrients and cardiovascular disease and mortality is controversial. Most available data are from European and North American populations where nutrition excess is more likely, so their applicability to other populations is unclear.. METHODS: The Prospective Urban Rural Epidemiology (PURE) study is a large, epidemiological cohort study of individuals aged 35-70 years (enrolled between Jan 1, 2003, and March 31, 2013) in 18 countries with a median follow-up of 7·4 years (IQR 5·3-9·3). Dietary intake of 135 335 individuals was recorded using validated food frequency questionnaires. The primary outcomes were total mortality and major cardiovascular events (fatal cardiovascular disease, non-fatal myocardial infarction, stroke, and heart failure). Secondary outcomes were all myocardial infarctions, stroke, cardiovascular disease mortality, and non-cardiovascular disease mortality. Participants were categorised into quintiles of nutrient intake ...
I would suspect that the different effects of anti-oxidants in healthy and unhealthy individuals may well be attributed to different levels of "pro-oxidant" activity. Recent studies (e.g. Ristow et.al. 2009) have shown that a certain amount of oxidation as induced by resistant exercise is necessary to trigger the health-promoting effects of physical exercise in humans - huge amounts of anti-oxidants will prevent these efffects. If, on the other hand, the oxidation processes exceed a certain level or are induced by an unhealthy diet, the provision of appropriate amounts of anti-oxidants is obviously beneficial for overall health. It is - as always - a matter of keeping things balanced ...
In this issue, 2 articles (5, 6) express widely divergent views regarding the role of CRP in cardiovascular disease risk stratification. Because individuals at greatest risk for disease have the most to gain from medical interventions (7), correctly specifying level of risk is an important clinical task. Both Cook and colleagues (5) and Lloyd-Jones and coworkers (6) investigate whether adding CRP to predictive models could usefully improve the ability of clinicians to target interventions. Lloyd-Jones and coworkers (6), who review the published evidence, show that adding CRP to predictive models containing conventional cardiovascular risk factors leads to minor improvement in measures of discrimination (receiver-operator characteristic curve properties or c-statistics). This finding is in line with the findings of the most recent study on this issue (8). Cook and colleagues (5) argue that these measures of discrimination are not appropriate for evaluating the utility of adding single variables ...
Background-Fibroblast growth factor-23 (FGF-23) is a phosphate regulatory hormone that directly stimulates left ventricular hypertrophy in experimental models. The role of FGF-23 in cardiovascular disease development in the general population is unclear. We tested associations of FGF-23 with major subclinical and clinical cardiovascular disease outcomes in a large prospective cohort. Methods and Results-We evaluated 6,547 participants from the Multi-Ethnic Study of Atherosclerosis (MESA) who were initially free of cardiovascular disease. We measured serum FGF-23 using the Kainos immunoassay. The MESA measured left ventricular (LV) mass by magnetic resonance imaging, coronary calcium (CAC) by computed tomography, and carotid intima-medial thickness (IMT) by ultrasound. The MESA adjudicated incident heart failure, coronary heart disease, and stoke by medical record review. After adjustment, the highest FGF-23 quartile was associated with an estimated 2.4 gram greater LV mass (95% CI 0.4, 4.5 ...
Adults with late-onset asthma had a significantly increased risk of cardiovascular disease events such as MI, stroke and heart failure compared with those who did not have asthma even after adjusting for age, sex and cardiovascular disease risk factors.
Cardiovascular diseases constitute one of the major causes of disability and death all over the world. Increased mechanisation, Westernisation of lifestyle and genetic factors, coupled with an increase in life expectancy owing to control of infectious diseases, have contributed to its rise in the developing world as well.. Despite remarkable advances in the identification of various risk factors and our enhanced knowledge regarding the aetiopathogenesis of cardiovascular diseases and molecular targeting for drug development, effective drug management of cardiovascular diseases still eludes medical researchers. There continues to be an unmet need for better and safer drugs to treat as well as to prevent cardiovascular diseases. In this regard, it is important to remember that many of the cardiovascular diseases are preventable, either by lifestyle modification and/or by drugs.. The past few decades have witnessed the introduction of a remarkable number of not only new drugs, but also new classes ...
WOODBRIDGE, ON, Oct. 9, 2012/ PRNewswire/- Pivotal Therapeutics Inc., a specialty pharmaceutical company with a focus on cardiovascular disease and overall health, is pleased to announce that the company will be exhibiting at the 2012 Cardiometabolic Health Congress in Boston, MA October 10-13, 2012 Booth #513. The CMHC attracts over 1000 U.S. based practicing clinicians and provides a forum for the most current information on preventing, diagnosing and managing cardiovascular and metabolic disorders.
include being overweight, smoking, diabetes, high cholesterol, and high blood pressure. Digital health interventions include telemedicine, Web-based (Internet) strategies, e-mail, mobile phones, mobile applications, text messaging, and monitoring sensors. These methods have been used to help people monitor their health and change behaviors, reducing their risk for preventable diseases.. ...
Background The presence of pets has been associated with reduction of stress and blood pressure and therefore may reduce the risk of cardiovascular diseases. Methods Relative risks (RR) of all deaths, death due to myocardial infarction (MI), cardiovascular diseases (MI or stroke), and stroke during a 20 year follow-up were determined by Cox proportional hazards analysis for categories of cat or dog ownership among participants after adjustment for potential confounding...
Over the past few years, weve seen an increased focus on health problems associated with cardiovascular disease in people with HIV. Theres still ...
Over the past few years, weve seen an increased focus on health problems associated with cardiovascular disease in people with HIV. Theres still ...
Multiple cardiovascular-related gene sequencing tests can be performed on a single specimen after a single extraction. See Multiple Cardiovascular-Related Gene Sequencing Tests in Special Instructions for a list of tests that can be ordered together.. Container/Tube: Lavender top (EDTA). Specimen Volume: 3 mL. Collection Instructions: Send specimen in original tube.. Additional Information: Include physician name and phone number with the specimen.. ...
CARDIOVASCULAR DISEASE : THE COMPLETE INTRODUCTION (Book) : Juneau, Martin : A complete guide to the treatment and prevention of cardiovascular disease. Being diagnosed with a cardiovascular disease seems unlikely to many, yet cardiovascular diseases are actually the leading cause of mortality worldwide. The good news is that by modifying our lifestyle habits, its possible to increase both our number of healthy years and our lifespan. While modern medicine has an impressive arsenal of drugs, imaging techniques, and intervention procedures and can usually save patients in the acute phase of a heart attack, heart specialists recommend that we adopt a proactive attitude with respect to disease prevention.In a simple, easy-to-read style, Dr. Martin Juneau examines specific case studies from his own extensive clinical practice to explain new issues in heart health. From the incredible importance of exercise and diet to the unsuspected role ofstress and air pollution, Cardiovascular Health explains how the
Main results. 46% of patients with RA and 36% of those without RA had a first CV event during follow-up. Patients with RA were more likely to have been current or former smokers at baseline (52% vs 43%, P = 0.004). Absolute 10-year CV risk varied with age and was 10% to 56% in those with RA and 2% to 37% in those without RA (Table). For patients with RA and 5 traditional CV risk factors, 10-year CV risk was 2 to 5 times higher than for those with RA and no risk factors (Table). ...
TY - JOUR UR - http://lib.ugent.be/catalog/pug01:7030484 ID - pug01:7030484 LA - eng TI - Combined influence of healthy diet and active lifestyle on cardiovascular disease risk factors in adolescents PY - 2014 JO - (2014) SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS SN - 0905-7188 PB - 2014 AU - Cuenca-García, M AU - Ortega, FB AU - Ruiz, JR AU - Gónzalez-Gross, M AU - Labayen, I AU - Jago, R AU - Martínez-Gómez, D AU - Dallongeville, J AU - Bel-Serrat, S AU - Marcos, A AU - Manios, Y AU - Breidenassel, C AU - Widhalm, K AU - Gottrand, F AU - Ferrari, M AU - Kafatos, A AU - Molnár, D AU - Moreno, LA AU - De Henauw, Stefaan GE12 801000760293 0000-0003-4141-5432 AU - Castillo, MJ AU - Sjöström, M AB - To investigate the combined influence of diet quality and physical activity on cardiovascular disease (CVD) risk factors in adolescents, adolescents (n=1513; 12.5-17.5 years) participating in the Healthy Lifestyle in Europe by Nutrition in Adolescence study were studied. Dietary intake ...
Healio brings you the highlights from the Cardiometabolic Health Congress. Refer back to this page often for the latest news from CMHC, perspectives and interviews with leading researchers and clinicians, and to review archives of past meetings.
The primary findings from this large, prospective, population‐based cohort study showed that higher visit‐to‐visit variability of FPG was associated with an increased risk for CVD events and all‐cause mortality over a 4.93‐year follow‐up. These findings were obtained after adjustment for traditional CVD risk factors, including a history of diabetes mellitus, hypertension, dyslipidemia, and mean FPG levels.. In accordance with our findings, the Verona Diabetes study16 and a dynamic cohort study in China9 reported that fasting glycemic variability may be an independent predictor of mortality in patients with type 2 diabetes mellitus. In addition, multiple studies from the intensive care unit setting have shown a strong relationship between glycemic variability and mortality.17, 18, 19, 20, 21, 22, 23, 24 Critically ill patients with a wide glycemic variation appear to be at significantly higher risk for death, regardless of whether they are hospitalized in medical, surgical, pediatric, ...
BackgroundMild to moderate chronic kidney disease (CKD) is associated with increased risk for cardiovascular disease. The burden of cardiovascular disease risk
There were 3 major findings from this study (Central Illustration). First, runners had consistently lower risk of all-cause and CVD mortality compared with nonrunners. Second, running even at lower doses or slower speeds was associated with significant mortality benefits. Third, persistent running over time was more strongly associated with mortality reduction.. An earlier study found a 39% lower risk of all-cause mortality in 538 runners who were ≥50 years of age from the Runners Association database compared with 423 matched nonrunners from the Lipid Research Clinics database after adjustment for baseline age, sex, and functional ability (12). In our subsample of runners ≥50 years of age, we found 29% lower mortality risk, compared with nonrunners. The somewhat greater mortality benefits of running in the earlier study may be because runners from a running club were more likely to be health conscious, and physical activities other than running were not adjusted for in the ...
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On September 13, 2011, this report was posted as an MMWR Early Release on the MMWR website (http://www.cdc.gov/mmwr).. Cardiovascular disease (CVD) causes one in three (approximately 800,000) deaths reported each year in the United States (1). Annual direct and overall costs resulting from CVD are estimated at $273 billion and $444 billion, respectively (2). Strategies that address leading CVD risk factors, such as hypertension, high cholesterol levels, and smoking, can greatly reduce the burden of CVD (3). To estimate the U.S. prevalence of these three risk factors, CDC analyzed data from the National Health and Nutrition Examination Survey (NHANES) on uncontrolled hypertension, uncontrolled high levels of low-density lipoprotein cholesterol (LDL-C), and current smoking. This report summarizes the results of that analysis, which found that 49.7% of U.S. adults aged ≥20 years (an estimated 107.3 million persons) have at least one of the three risk factors. To reduce the prevalence of CVD risk ...
Race- and sex-specific Pooled Cohort Equations to predict 10-year risk for a first hard ASCVD (atherosclerotic cardiovascular disease) event
Results 24,989 subjects followed for a median of 2.3 years were included in these analyses. During follow-up, we observed 422 CV endpoints for an incidence rate of 9.08 (95% confidence interval, CI, 7.90 - 10.26) per 1,000 person-years. In models adjusting for age, gender, known CV disease, other traditional CV risk factors, and baseline medications, a 10-point reduction in cumulative CDAI was associated with a 26% reduction in CV risk (95% confidence interval 17-34%). These results were robust in sensitivity analyses (see Fig. 1) stratified by known CV disease, use of corticosteroids, use of non-steroidal anti-inflammatory drugs or selective COX-2 inhibitors, and change in RA treatment.. ...
Our objective was to assess the link between season of birth, neonatal 25-hydroxyvitamin D3, and adult cardiovascular disease; we report higher neonatal 25(OH)D3 associated with higher levels of cholesterol (in women), fasting insulin, and triglyceride, and with a higher risk of overweight at 35 years of age, but not with other adult cardiovascular disease risk factors ...
Information on heart disease and related cardiovascular conditions includes medications, procedures and tests, symptoms, and treatment.
Information on heart disease and related cardiovascular conditions includes medications, procedures and tests, symptoms, and treatment.
Free NCLEX-PN flashcards - Conditions and Treatments - Cardiovascular Conditions. Work through hundreds of free flashcards and see your grades and test scores i
BACKGROUND: The level of mortality from cardiovascular disease (CVD), coronary heart disease (CHD) and from all causes varies considerably within Oslo. The purpose of this study was to examine these differences according to cardiovascular risk factors and socioeconomic variables at the district level. METHODS: Total mortality rates and cardiovascular mortality rates for subjects aged 45-74 years in 1991-1995, and their relationship to cardiovascular risk factors and socioeconomic indicators in the 25 districts of Oslo were studied. Cardiovascular risk factors were based on data from 40 year olds in 1985-1988. The following variables were used as independent variables in the regression analyses to explain differences between the districts: daily smoking, cholesterol level, systolic blood pressure, education and income. RESULTS: Mortality rates were strongly related to cardiovascular risk factors and to socio-economic indicators, with correlation coefficients (Pearson) of 0.74 for smoking and CVD ...
Organized by Dr. Michael Ozner, the Cardiovascular Disease Prevention Symposium is an annual gathering of visionary cardiologists focused on conquering heart disease. Topics included PCSK9 to reduce cholesterol, benefits of fish oil and biomarkers of coronary artery disease.
Body Composition Indices and Single and Clustered Cardiovascular Disease Risk Factors in Adolescents: Providing Clinical-Based Cut- ...
CME Program sponsored by International Society for Cardiovascular Disease Prevention and Cardiovascular Center of Sarasota ABC members receive 50% discount…
Both, ADMA, and CRP predict the occurrence of cardiovascular events in patients with type 2 diabetes. Combining both parameters showed that ADMA augments the predictive value of CRP as a cardiovascular risk marker. Patients with ADMA or CRP in the highest tertile, and none of these parameters in the lowest tertile, had a 4.5-times increased risk for the occurrence of cardiovascular events compared with those with neither ADMA nor CRP in the highest tertile. This imposes an important role of ADMA for cardiovascular risk stratification, adding to determination of CRP and traditional cardiovascular risk markers. A significant additional predictive value of ADMA to CRP for all-cause and cardiovascular mortality in patients with end-stage renal disease already has been shown in a previous study (19). Our study extends these findings to patients with type 2 diabetes. Risk stratification in patients with type 2 diabetes is of particular relevance. Patients with type 2 diabetes are prone to a ...
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History of established coronary artery disease (CAD)as defined by coronary stenosis in one or more vessels greater than or equal to 70% by coronary angiography or CT angiogram OR abnormal stress test (at least medium-sized, moderate reversible defect) OR a presence of a CAD risk equivalent as defined by the National Cholesterol Education Panel (NCEP)III as: Framingham risk score ≥ 20%, diabetes, or peripheral arterial disease(4 ...
History of established coronary artery disease (CAD)as defined by coronary stenosis in one or more vessels greater than or equal to 70% by coronary angiography or CT angiogram OR abnormal stress test (at least medium-sized, moderate reversible defect) OR a presence of a CAD risk equivalent as defined by the National Cholesterol Education Panel (NCEP)III as: Framingham risk score ≥ 20%, diabetes, or peripheral arterial disease(4 ...
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Cardiovascular disease (CVD) is the number one cause of morbidity and mortality worldwide, and an estimated 17.5 million people died from CVD in 2012 representing 31% of all global deaths.1 In the UK, the total CVD mortality declined by 68% between 1980 and 2013, while the hospital admissions increased by over 46 000 between 2010/2011 and 2013/2014.2 Current statistics of premature deaths due to CVD ranges from 4% in high-income countries to an astonishing estimate of 80% of the total CVD mortality in developing countries.3 In addition, the disease burden on the individual and society comes from deaths and also from those living with CVD. The American Heart Association estimated that the total direct and indirect cost of CVD in the USA alone for 2010 was in excess of US$500 billion.4 According to the WHO,1 the major risk factors of CVD are related to lifestyles, including tobacco smoking, unhealthy diet, physical inactivity and alcohol abuse. These factors may lead to other contributing risk ...
What began as molecular switches linking cell surface receptors to the reorganization of the actin cytoskeleton has now emerged as an important mediator of cardiovascular disease. The low-molecular-weight GTPases of the Rho family have appeared with increasing frequency in the cardiovascular literature. This interest stems from two seemingly opposite disciplines. From a basic science perspective, increasing evidence suggests a central role of Rho-dependent actin cytoskeleton in mediating changes in cell shape, contractility, and motility.1 However, how these actin cytoskeletal effects of Rho translate into cardiovascular pathophysiology is not entirely evident. From a clinical perspective, large prospective trials with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors or statins suggest that these agents may have beneficial effects in cardiovascular disease in addition to their cholesterol-lowering effects.2 The realization that statins also inhibit isoprenoid synthesis,3 which is required for ...
Clinical trial for Statin Adverse Reaction | Cardiovascular Disease , Evaluation of Major Cardiovascular Events in Patients With or at High Risk for Cardiovascular Disease Who Are Statin Intolerant Treated With Bempedoic Acid (ETC-1002) or Placebo
Trials to date have found that statins reduce all-cause mortality, composite cardiovascular outcomes, and revascularization. However, most trials included large numbers of persons with known CVD. Clear evidence of the effectiveness of statins to prevent a first cardiovascular event is lacking.
Cardiovascular disease is any disease of the heart or blood vessels. It can take many forms, but in many cases, it is preventable. To learn how to keep your heart healthy and prevent development of cardiovascular disease, see a healthcare professional in Tarzana, CA.
Editors Note: This is Part I (Pros) of a two-part Expert Analysis. Go to Part II (Cons).. The Systolic Blood Pressure Intervention Trial (SPRINT) was designed to test the hypothesis that systolic blood pressure (SBP) reduction to a goal of less than 120 mm Hg had a greater impact on fatal and non-fatal cardiovascular events than reducing SBP to the goal of ,140 mm Hg,1 the current guideline recommendation in the U.S. and Europe for persons ,60 years old and those with chronic kidney disease (CKD) and diabetes mellitus (DM).2,3 Although these SBP goals were similar to those in the BP-lowering arm of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial that enrolled only patients with diabetes,4 SPRINT enrolled considerably more hypertensive patients ≥50 years old without diabetes (n = 9,361) who were at increased cardiovascular risk because of pre-existing cardiovascular disease (CVD), CKD stage II-III, age ,75 years, or a Framingham 10-year CVD risk score of ≥15%.5 At ...
Cardiovascular disease is the leading cause of death in developed countries. Despite worldwide extensive research in the past several decades, effective therapeutic interventions reducing cardiovascular mortality are limited. It is increasingly recognized by the cardiovascular community that eliminating the risk factors and preventing the development of cardiovascular disease is a much better strategy in our battle against cardiovascular disease morbidity and mortality. The central focus of our laboratory is to identify the mechanisms responsible for myocardial ischemia/reperfusion injury, for the ultimate purpose of clinical translational benefit. We currently work upon research directions attempting to identify new therapeutic targets at the molecular, cellular, organ and in vivo animal model levels that may block cardiovascular complications caused by the metabolic syndrome, the number one risk factor for cardiovascular disease.. ...
This video is available to view via Safari on iPad.. Professor Julie Lovegrove (Deputy Director, Institute for Cardiovascular and Metabolic Research, University of Reading) gives an overview of the role of dietary lipids in cardiovascular disease risk, with reference to her own research, as well as international studies.. This lecture was filmed at an event called: Nutritional approaches to cardiovascular health.. RSM event description: Despite recent improvements, cardiovascular disease (CVD) remains the leading cause of death worldwide. In England and Wales CVD currently accounts for some 37% of deaths. According to the World Health Organization (WHO) up to 80% of these cases can be avoided by changing to a healthier diet, increasing physical activity and stopping smoking. As evidence to support this, a lifestyle intervention in Finland led to a 68% reduction in premature deaths from CVD in the period 1970 to 1995.. The intention of this conference is to highlight nutritional strategies ...
The 2013 ACC/AHA Cholesterol Guidelines expand the recommendations for statin use to populations previously felt to be at lower risk. Central to risk-estimation in these guidelines is a new equation for determination of atherosclerotic cardiovascular disease (ASCVD) risk. However, this risk model has been criticized overestimating ASCVD risk in validation studies of the model. Using the Womens Health Study, Cook et al. sought to determine the reasons for risk-overestimation by the ACC/AHA model. Among 27,542 women, 632 experienced an ASCVD event, defined as any myocardial infarction, any stroke, or death from a cardiovascular cause. The average 10-year predicted risk was 3.6% in comparison to an observed risk of 2.2%. When stratified by risk, the ratio between predicted to actual rates was greater for lower risk groups (less than 7.5% risk; ratio 1.90 or higher) than higher risk groups (greater than or equal to 7.5% risk; ratio over 1.4). Statin use and revascularization rates increased over ...
Matthew D. Ritchey, DPT1, Hilary K. Wall, MPH1, Cathleen Gillespie, MS1, Mary G. George, MD1, Ahmed Jamal, MBBS2 (Author affiliations at end of text). Each year, approximately 1.5 million U.S. adults have a heart attack or stroke, resulting in approximately 30 deaths every hour and, for nonfatal events, often leading to long-term disability (1). Overall, an estimated 14 million survivors of heart attacks and strokes are living in the United States (1). In 2011, the U.S. Department of Health and Human Services, in collaboration with nonprofit and private organizations, launched Million Hearts (http://www.millionhearts.hhs.gov), an initiative focused on implementing clinical and community-level evidence-based strategies to reduce cardiovascular disease (CVD) risk factors and prevent a total of 1 million heart attacks and strokes during the 5-year period 2012-2016 (2,3). From 2005-2006 to the period with the most current data, analysis of the Million Hearts four "ABCS" clinical measures (for ...
Cardiovascular disease is actually a general term used for conditions that affect the heart or even the blood vessels. CVD is associated usually with the accumulation of fatty deposits right inside your arteries, called atherosclerosis. There would certainly be a rise in the risk of blood clotting. CVD could be related to the damage to your arteries present in the heart, brain, eyes, and kidneys. Cardiovascular disease is actually one of the major causes of disability and death in many nations today. Here are some kinds of cardiovascular diseases.. Ischemic Heart Disease. Ischemic Heart Disease is supposed to be the most common kind of CVD in many industrialized nations across the globe. It is associated with blood circulation issues to your heart muscle. A partial blockage present in one or even more of your coronary arteries could lead to a short supply of oxygenated blood (ischemia) resulting in symptoms like dyspnea or shortness of breath and angina or chest pain. A full blockage of one of ...
Background: This study was performed to evaluate periodontal status in patients with cardiovascular disease (CVD) and assessment of periodontal diseases prevalence in these patients. Materials and Methods: In this cross-sectional study, data on 100 patients were collected with mean age of 51 ± 11 years. The case group included of ...
Background: Conventional factors do not fully explain the distribution of cardiovascular outcomes. Biomarkers are known to participate in well-established pathw
Ambrosio G, Tritto I, Golino P. Reactive oxygen metabolites and arterial thrombosis. Cardiovasc. Research 34:445-452, 1997 Medline. Berenson GS, Srinivasan SR, Bao W, Newman WP III, Tracy RE, Wattigney WA. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. New England Journal of Medicine 338: 1650-1656, 1998 Medline. Breslow JL, Azrolan N, Bostom A. N-acetylcysteine and lipoprotein. Lancet 339: 126-127, 1992 Medline. Ceconi C, Curello S, Cargnoni A, et al. The role of glutathione status in the protection against ischaemic and reperfusion damage: effects of N-acetylcysteine. J. Mol. Cell. Cardiol. 20: 5-13, 1988 Medline. Cheng KM, Aggrey SE, Nichols CR, Garnett ME, Godin DV. Antioxidant enzymes and atherosclerosis in Japanese quail: Hereditability and genetic correlation estimates. Canadian Journal of Cardiology 13:669-676, 1997 Medline. Dhalla NS, Golfman L, Takeda S, et al. Evidence for the role of oxidative stress in acute ischemic heart ...
New research has found that poorer well-being or health-related quality of life (HRQoL) in adolescence could be an indicator of future cardiovascular disease risk. Researchers at The Westmead Institute for Medical Research found that adolescents with poorer scores in the social and mental well-being domains of HRQoL have structural changes in their retinal blood vessels that could be associated with an increased risk of cardiovascular disease in later life.
Today results from a new sub-analysis of the EMPHASIS-HF study showed significant reductions in death and hospitalization for five pre-defined high-risk patient sub-groups with chronic heart failure (CHF) and mild symptoms ...
Modest weight losses of 5-10% have been associated with significant improvements in cardiovascular disease risk factors (ie, decreased HbA1c levels, reduced blood pressure, increase in HDL cholesterol... more
What is associated with significantly increased risk of stroke and total cardiovascular disease? Many of us are consuming far too much salt and its taking a
En blodprop i hjertet er en alvorlig livsbegivenhed, og mange påvirkes psykisk efterfølgende. Dette studie viser, at hver anden patient, som har haft en blodprop i hjertet, og som har et svækket mentalt helbred, dør eller får et nyt tilfælde af hjertekarsygdom i løbet af de efterfølgende tre år, mens dette kun er tilfældet for hver syvende af dem med et godt mentalt helbred. Den øgede risiko hænger sammen med forskelle i sværhedsgraden af hjertesygdom, men fysisk aktivitet og depressions- og angstsymptomer synes også at spille en rolle. Selv når forskerne tager højde for disse faktorer, har hjertepatienter med et svækket mentalt helbred en over dobbelt så stor risiko for at dø eller få et nyt tilfælde af hjertekarsygdom sammenlignet med hjertepatienter med et godt mentalt helbred. Årsagerne til denne sammenhæng kendes ikke. Nogle af forklaringerne kunne være, at mennesker med et svækket mentalt helbred ikke får de samme behandlingstilbud som mere ressourcestærke ...
Good morning class You are asked to evaluate a patient pre-operatively. They have multiple cardiovascular risk factors including a significant smoking history and hypertension. 16 weeks ago they were hospitalised with central chest pain and they tell you they spent some time in the coronary care unit. You are aware that they are awaiting cancer…
Course Description:. This introductory course for fitness professionals will teach individuals how to safely work with clients with cardiovascular risk factors or diagnosed cardiovascular disease. Health professionals need to be able to identify those at risk for CVD and develop exercise programs and recommend lifestyle changes that will reduce the risk of CVD. Exercise and fitness professional also need to be able to program exercise for those with cardiovascular disease or individuals who has suffered myocardial infarctions or have had procedures, such as bypass surgery. This course introduces professionals to the fundamentals of being physically active with CVD and what types of training may be appropriate or contraindicated.. CVD is the leading cause of death in the United States and has been for many years. Most fitness professionals have a limited knowledge of the different types of CVD and the symptoms that go along with them. They need to understand which activities and exercises are ...
Nutritional exposures in early life can have a long-lasting effect on cardiovascular disease (CVD) risk in adulthood. However, few specific dietary factors have...
... are conditions that involve narrowed or blocked blood vessels that can lead to a heart attack, chest pain (angina) or stroke. Many risk factors can be treated, such as tobacco exposure, high blood pressure (hypertension), high cholesterol, obesity, physical inactivity, diabetes, unhealthy diets, and harmful use of alcohol.
Source: SeanPavonePhoto / Getty Images20. Maine | Prevalence of major cardiovascular disease: 7.5% | Adults who report healthy weight: 32.2% (22nd highest) | Adults who report fair or poor health: 16.4% (23rd lowest) | Median household income: $56,277 (20th lowest)Source: Thinkstock19. Florida | Prevalence of major cardiovascular disease: 7.6% | Adults who report healthy weight: […]
AIMS/HYPOTHESIS:. The study aimed to assess the relative importance of the control of HbA(1c) and total cholesterol/HDL-cholesterol ratio (TC/HDL) on risk of cardiovascular disease (CVD).. METHODS:. In 22,135 participants with type 2 diabetes (age 30-75 years, 15% with previous CVD) followed for 5 years, baseline and annually updated mean HbA(1c) and TC/HDL were analysed and also categorised in combinations of quartiles. Outcomes were fatal/non-fatal CHD, stroke, CVD and total mortality.. RESULTS:. In all participants, HRs per 1 SD increase in updated mean HbA(1c) or TC/HDL using Cox regression analysis were 1.13 (95% CI 1.07, 1.19) and 1.31 (1.25, 1.37) for CHD, 1.15 (1.06, 1.24) and 1.25 (1.17, 1.34) for stroke, 1.13 (1.08, 1.18) and 1.29 (1.24, 1.34) for CVD (all p , 0.001), and 1.07 (1.02, 1-13; p = 0.01) and 1.18 (1.12, 1.24; p , 0.001) for total mortality, respectively, adjusted for clinical characteristics and traditional risk factors. The p value for the interaction between HbA(1c) and ...
European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). http://www.escardio.org/guidelines-surveys/esc-guidelines/Pages/cvd-prevention.aspx The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Perk J., De Backer G., Gohlke H., Graham I., Reiner Z., Verschuren M., Albus C, Benlian P, Boysen G, Cifkova R, Deaton C, Ebrahim S, Fisher M, Germano G, Hobbs R, Hoes A, Karadeniz S, Mezzani A, Prescott E, Ryden L, Scherer M, Syvänne M, Scholte op Reimer WJ, Vrints C, Wood D, Zamorano JL, Zannad F. European Heart Journal (2012) 33, 1635- ...
With a little effort on each of our parts and a willingness to change, we can make a big difference in the incidence of this nations number one killer, cardiovascular disease (CVD). Heart and blood vessel disease are not inevitable; in fact, they are preventable in most cases.
Long standing type 2 diabetes mellitus (T2DM) is associated with cardiovascular complications, and increased morbidity and mortality outcomes. Therefore, the optimal management of T2DM should not only aim at achieving glycemic control, but should also include the management of cardiovascular risk factors and associated CVD. Unfortunately, diabetes is increasing in prevalence in the U.S., and both glycemic and CVD risk control is generally suboptimal. Furthermore, cardiovascular risk in patients with diabetes may remain underrecognized and undertreated while clinicians are unaware of recent developments in evidence-based approaches to CVD event reduction.. In this 90-minute program, the program moderator Dr. Keith Ferdinand will interview 3 faculty thought leaders, Drs. Mark Stolar, Alanna Morris and Bob Chilton, to address the multiple issues facing patients with diabetes and the risks of cardiovascular disease. This educational program will discuss the increasing burden of comorbid ...
Clinical trial for Atherosclerotic Cardiovascular Disease | Symptomatic Atherosclerosis | Type2 Diabetes | Familial Hypercholesterolemia , An Extension Trial of Inclisiran Compared to Evolocumab in Participants With Cardiovascular Disease and High Cholesterol
The focus of this journal club will continue to be the presentation of research being conducted by the CVD training grant trainees and faculty collaborating with the URL, as it relates to subclinical cardiovascular disease. This may take the form of pract...
The IDEFICS examinations program for children included measurements, among others, of weight, height, skinfolds, waist circumference, bioelectrical impedance and blood pressure, as well as questionnaires on socio-demographic factors and dietary habits, which made possible to analyse the weight status of European children. Below you find a list of articles on results from these measurements:. ...
The IDEFICS examinations program for children included measurements, among others, of weight, height, skinfolds, waist circumference, bioelectrical impedance and blood pressure, as well as questionnaires on socio-demographic factors and dietary habits, which made possible to analyse the weight status of European children. Below you find a list of articles on results from these measurements:. ...
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Identifying causes of death and related risk factors in patients with type 2 diabetes and ASCVD (cardiovascular disease) may help with prevention.
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Because diagnosis and treatments have been improving steadily over the last decades, more men than ever before are now living longer with cardiovascular disease. In the last century, heart attacks were the most common cause of death by a significant margin. Now with better drugs and lifestyle changes, deaths from cardiovascular disease have been falling. But this does not mean that these men have a satisfactory quality of life. The majority of men are now older, overweight, living in deprived areas and depressed. Many also find themselves affected by Type 2 Diabetes as the weight increases. Its difficult to prevent this development because, with limited budgets, most men cannot afford healthy food options. Cheap processed food has a high fat content and excess salt. General risks are increased significantly if the men also smoke and neglect to take any physical exercise.. As a routine, men should be encouraged to monitor their waist measurements as a simple means of judging when the risks are ...
These cardiovascular disease (CVD) profiles provide a snapshot of key issues relating to heart disease and stroke, including prevention, incidence, mortality, risk factors and treatments. These profiles have been designed to help health and well-being boards and local health services to assess the impact of these elements of cardiovascular disease on their local populations and the services provided to meet those needs. They are intended to inform commissioning and planning decisions to tackle CVD and improve the health of local communities. To view please click here: http://bit.ly/Z2FFtG. ...
The present book covers the basic principles of cardiovascular physiology, pathophysiology and advanced pharmacology with particular emphasis on cellular mechanisms of drug action. It provides an update on the progress made in several aspects of cardiovascular diseases so that it might kindle scientists and clinicians alike in furthering basic and translational research. In addition, the book is expected to fill imperative gaps in understanding and optimally treating cardiovascular disease ...
The USPSTF recommends against screening with resting or exercise electrocardiography (ECG) to prevent cardiovascular disease (CVD) events in asymptomatic adults at low risk of CVD events.
Cardiovascular disease news, research studies and CVD clinical treatment studies keeping medical professionals updated on the latest cardiovascular disease (CVD) news.
This research quantifies the lag effects and vulnerabilities of temperature effects on cardiovascular disease in Changsha-a subtropical climate zone of China. A Poisson regression model within a distributed lag nonlinear models framework was used to examine the lag effects of cold- and heat-related CVD mortality. The lag effect for heat-related CVD mortality was just 0-3 days. In contrast, we observed a statistically significant association with 10-25 lag days for cold-related CVD mortality. Low temperatures with 0-2 lag days increased the mortality risk for those ≥65 years and females. For all ages, the cumulative effects of cold-related CVD mortality was 6.6% (95% CI: 5.2%-8.2%) for 30 lag days while that of heat-related CVD mortality was 4.9% (95% CI: 2.0%-7.9%) for 3 lag days. We found that in Changsha city, the lag effect of hot temperatures is short while the lag effect of cold temperatures is long. Females and older people were more sensitive to extreme hot and cold temperatures than males and
Diets low in fruit and vegetables are reportedly responsible for 2.7 million deaths annually from cardiovascular diseases (CVD) and certain cancers. A daily fruit and vegetable intake of five 80 g portions is recommended for chronic disease prevention. However, in the UK, average adult consumption is less than three portions. It is suggested that fruit juice should only count as one portion. However, fruit juices are a beneficial source of phytochemicals. The preliminary results of two randomized, controlled, crossover, dietary intervention studies investigating the effects of chronic and acute consumption of fruit and vegetable puree and juice based drinks (FVPJ) on bioavailability, antioxidant status, vascular reactivity, and risk factors for CVD are reported. In the first study, 39 volunteers consumed 200 ml FVPJ, or fruit-flavoured control, daily for six weeks. In the second study, 24 volunteers consumed 400 mL FVPJ, or sugar-matched control, on the morning of the study day. Blood and urine ...
TY - JOUR. T1 - Gender-specific, lifestyle-related factors and 10-year cardiovascular disease risk; the ATTICA and GREECS cohort studies. AU - Kouvari, Matina. AU - Panagiotakos, Demosthenes B.. AU - Chrysohoou, Christina. AU - Georgousopoulou, Ekavi. AU - Notara, Venetia. AU - Tousoulis, Dimitrios. AU - Pitsavos, Christos. PY - 2019. Y1 - 2019. N2 - Background: Lifestyle remains a huge driving force of Cardiovascular Diseases (CVD) on-set/progression. Lifestyle-patterns are highly dependent on gender-related attitudes. Objective: To evaluate the gender-specific association of lifestyle-related factors (adherence to Mediterranean diet (MedDiet), Physical Activity (PA), smoking) with 10-year first and recurrent CVD events. Methods: Two prospective studies, the ATTICA (2002-2012, n=3,042 subjects free-of-CVD) and GREECS (2004-2014, n=2,172 subjects with Acute Coronary Syndrome (ACS)) were undertaken. Baseline adherence to MedDiet (MedDietScore ,27/≥27, range 0-55), PA (sedentary/physically ...
Aim To explore the genetic and environmental influences on cardiovascular risk factors (CVRF) and cognitive function in the worlds largest and rapidly aging Chinese population. Methods Cognitive function and CVRF, including body mass index, systolic blood pressure, diastolic blood pressure, pulse pressure, glucose, total cholesterol, triglyceride, high‐density lipoprotein cholesterol (HDLC) and low‐density lipoprotein cholesterol were measured in 379 complete twin pairs. Univariate and bivariate twin models were fitted to estimate the genetic and environmental components in the variance and covariance of CVRF and cognition. Results Mild‐to‐high heritability was estimated for CVRF and cognition (0.27-0.74). Unique environmental factors showed low‐to‐moderate contributions (0.23-0.56). Only HDLC presented significant common environmental contribution (0.50). Bivariate analysis showed significantly negative genetic correlations (rG) between cognition and systolic blood pressure (rG = ...
BACKGROUND Low plasma concentrations of high-density lipoprotein (HDL) are associated with increased risk of cardiovascular disease. However, recently several studies have questioned the protective role of high plasma HDL levels. OBJECTIVE This study was designed to evaluate HDL functions in women with high plasma HDL cholesterol and very low risk profile with relation to subclinical carotid atherosclerosis (ATS). METHODS Included were 158 middle-aged women with plasma HDL |60 mg/dL and Framingham risk score |7% who had B-mode ultrasound of the carotid arteries. Subclinical ATS was determined by the presence of plaques and/or intima-media thickness (IMT) |1.0 mm. RESULTS ATS was observed in 51 women, with the majority (n=41) having carotid plaques, some with advanced morphology. In a multivariable model analysis, each, HDL or age, were independently associated with increased prevalence of ATS. Odds ratios for ATS were 3.1 and 2.5 greater for age|60 years and HDL |70 mg/dL, respectively. None of
Background Cardiovascular disease (CVD) is a leading cause of mortality and morbidity in patients with chronic kidney disease (CKD). In Taiwan, CVD is dominated by strokes but there is no robust evidence for a causal relationship between CKD and stroke. This study aimed to explore such causal association. Methods We conducted a nationwide retrospective cohort study based on the Taiwan National Health Insurance Research Database from 2004 to 2007. Each patient identified was individually tracked for a full three years from the index admission to identify those in whom any type of stroke developed. The study cohort consisted of patients hospitalized with a principal diagnosis of CKD and no traditional cardiovascular risk factors at baseline (n = 1393) and an age-matched control cohort of patients hospitalized for appendectomies (n = 1393, a surrogate for the general population). Cox proportional hazard regression and propensity score model were used to compare the three-year stroke-free survival rate of
Abstract:. Background: Non-communicable diseases constitute about 68% of global death annually. Among NCD deaths, cardiovascular diseases (CVD) ranks first with a share of 46.2% amounting to 17.5 million deaths. First degree relatives of patients with coronary heart disease have a higher risk of getting cardiovascular events due to interplay between genetic as well as environmental factors. The aim of this research WAS to assess the prevalence of Cardiovascular Disease (CVD) risk factors and to estimate the cardiovascular risk among first degree relatives of CAD patients. Methodology: A cross-sectional study was performed in first degree relatives of coronary artery disease patients in cardiology ward of JIPMER a tertiary care hospital in Puducherry. Overall 218 first degree relatives aged ≥18 were involved in study. The desired information was obtained using a pre-tested questionnaire and participants were also subjected to anthropometric measurements and laboratory investigations. WHO/ISH ...
In the present analysis, we observed no additional value of measurement of mean common CIMT in risk classification among 17 254 individuals free from symptomatic CVD, but with elevated blood pressure levels. For those at intermediate risk, the addition of common CIMT to an existing cardiovascular risk score is small but statistically significant. However, the decision on whether or not to implement common CIMT measurements in individuals with elevated blood pressure levels at intermediate risk depends on the balance between costs of additional risk assessment by CIMT measurements and effectiveness in preventing CVD.. In asymptomatic individuals with elevated blood pressure, guidelines recommend cardiovascular risk assessment and suggest screening for subclinical vascular damage.1,5-7 It has been suggested that providing a more accurate assessment of vascular damage related to hypertension may lead to a more precise stratification of CVD risk.20 As such, the 2007 ESH/ESC hypertension guidelines ...
After controlling for age and sex, we report not only that CHD risk factors but also that CCA and ICA IMTs are elevated in individuals before the onset of clinical diabetes. Moreover, increased CCA IMT predicted diabetes. Hence, in our study population, we have established that early atherogenesis, not merely elevated cardiovascular risk factors, is present before the development of clinical diabetes, and thus, enhanced atherogenesis is not solely dependent on the clinical manifestation of diabetes.. Jarrett,15 Jarrett and Shiply,16 and later Stern17,18 hypothesized not only that diabetes and cardiovascular disease are related as cause and effect but also that both conditions originate from a "common soil." This hypothesis suggests an atherogenic state before the onset of clinical diabetes, which is consistent with the regularly reported finding that CHD risk factors are elevated in prediabetic individuals1-5 and the recently reported finding in the Nurses Health Study (NHS) of elevated ...