TY - JOUR. T1 - miR-199a-5p is a marker of blood pressure in premature cardiovascular disease patients homozygous for the MTHFR C677T polymorphism.. AU - Lynch, Seodhna. AU - Ward, Mary. AU - McNulty, Helene. AU - Horigan, G. AU - Strain, JJ. AU - purvis, John. AU - tackett, Mike. AU - McKenna, Declan. PY - 2017/9/11. Y1 - 2017/9/11. N2 - Introduction: microRNAs are small, non-coding RNAs which are potentially valuable markers of cardiovascular disease (CVD) risk, including hypertension. This novel investigation aims to profile circulating serum concentrations of microRNAs in premature CVD patients to identify microRNAs that correlate best with hypertension.Methods: Serum samples from an existing cohort of 75 premature CVD patients were analysed for expression of 68 CVD-related microRNAs. Patients had been screened for the methylenetetrahydrofolate reductase (MTHFR) gene polymorphism C677T, a risk factor for hypertension. Samples had been collected at baseline and following intervention with ...
Overweight in adolescence is considered an important predictor of long-term morbidity and mortality. The impact of adolescent overweight on adult overweight and related multiple cardiovascular risk factors was examined in a biracial (black-white) cohort (N = 783) who participated in two cross-sectio …
© 2017 The Authors Health Expectations Published by John Wiley & Sons Ltd Objective: To examine the effect on cardiovascular (CVD) risk factors of interventions to alter consultations between practitioners and patients with type 2 diabetes. Search Strategy: Electronic and manual citation searching to identify relevant randomized controlled trials (RCTs). Inclusion Criteria: RCTs that compared usual care to interventions to alter consultations between practitioners and patients. The population was adults aged over 18 years with type 2 diabetes. Trials were set in primary care. Data extraction and synthesis: We recorded if explicit theory-based interventions were used, how consultations were measured to determine whether interventions had an effect on these and calculated weighted mean differences for CVD risk factors including glycated haemoglobin (HbA 1c ), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C).
Julius S, Kjeldsen SE, Weber M, Brunner HR, Ekman S, Hansson L, Hua T, Laragh J, McInnes GT, Mitchell L, Plat F, Schork A, Smith B, Zanchetti A, VALUE trial group. Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial. Lancet. 2004; 363(9426): 2022-31 ...
Background Cardiovascular disease may be the leading cause of increased mortality for adolescents with advanced kidney disease. cardiovascular mortality. Great opportunity exists to improve outcomes for children with kidney disease by improving reliability of preventive care that may include formal transition programs. Keywords: Cardiovascular disease, transition, quality, chronic kidney disease, kidney transplantation, dialysis Intro Outcomes for children with chronic kidney disease (CKD) and end-stage renal disease (ESRD) have improved with an increasing number surviving well into adulthood.[1C2] Unfortunately, many of these patients have cardiovascular disease (CVD) mortality rates over 1,000 instances that of their age-matched peers and will experience premature death due to CVD in early adulthood.[3C4] This exceedingly high CVD risk is related to a high prevalence of traditional cardiovascular risk factors (CVRFs) that predict CVD in the general population (such as hypertension, ...
Skeletal muscle mass in relation to 10 year cardiovascular disease incidence among middle aged and older adults: the ATTICA study ...
Methods and Results-In a double-blind controlled trial, we randomized 4110 stable kidney transplant recipients to a multivitamin that included either a high dose (n=2056) or low dose (n=2054) of folic acid, vitamin B6, and vitamin B12 to determine whether decreasing total homocysteine concentrations reduced the rate of the primary composite arteriosclerotic cardiovascular disease outcome (myocardial infarction, stroke, cardiovascular disease death, resuscitated sudden death, coronary artery or renal artery revascularization, lower-extremity arterial disease, carotid endarterectomy or angioplasty, or abdominal aortic aneurysm repair). Mean follow-up was 4.0 years. Treatment with the high-dose multivitamin reduced homocysteine but did not reduce the rates of the primary outcome (n=547 total events; hazards ratio [95% confidence interval]=0.99 [0.84 to 1.17]), secondary outcomes of all-cause mortality (n=431 deaths; 1.04 [0.86 to 1.26]), or dialysis-dependent kidney failure (n=343 events; 1.15 ...
Background: Mild cognitive impairment is a risk factor for dementia. Midlife cardiovascular disease risk factors such as high blood pressure and smoking have strong relationships to both cognitive impairment and dementia in late life. Intakes of several nutrients including fats and alcohol have been found to contribute to both cardiovascular disease and risk of cognitive impairment. Literature shows that cardiovascular disease risk factors at age 50, predict lifetime risk of both cardiovascular disease and dementia. The aim of this study is to investigate relationships between the intake of fats and alcohol in relation to cognitive impairment, and five-year cardiovascular disease risk (fatal and non-fatal) in 50 year old Cantabrians. The hypotheses for this study are: • That fifty year olds with higher five year cardiovascular disease risk have a higher risk of mild cognitive impairment. • Secondly that fifty year olds who consume the recommended proportions of dietary fats and recommended ...
The goal of this work was to perform an exploratory analysis to establish a framework for mt-PheWAS for investigating the relationship between mtDNA variation and a range of phenotypes. We first employed a polygenic approach to investigate the global effect of mtDNA variation on phenotypic variance for eight cardiovascular-related traits. Given the metabolic trait focus of the nuclear SNP content on the Metabochip and the nature of the selected phenotypes in this study, we expected the polygenic analysis would reveal significant proportion of trait variance explained. However, overall, we observed relatively low PVE for both nuclear and mitochondrial genetic variation. Only a single trait, total cholesterol, reached statistical significance in the polygenic analysis, although T2D approached the statistical significance threshold of p , 0.05. The low PVE may be due, in part, to the targeted nature of the Metabochip which does not contain a genome-wide distribution of SNPs that can be found on ...
TY - JOUR. T1 - Incidence of new cardiovascular events in patients with and without peripheral arterial disease seen in a vascular surgery clinic. AU - Chhabra, Amit. AU - Aronow, Wilbert S.. AU - Ahn, Chul. AU - Duncan, Kurt. AU - Patel, Jay D.. AU - Papolos, Alexander I.. AU - Sateesh, Babu. PY - 2012/1/1. Y1 - 2012/1/1. N2 - Background: To investigate the incidence of death and of new cardiovascular events at long-term follow-up of patients with and without PAD seen in a vascular surgery clinic. Material/Methods: We investigated the incidence of death, new stroke/transient ischemic attack, new myocardial infarction, new coronary revascularization, new carotid endarterectomy, new peripheral arterial disease (PAD) revascularization, or at least one of the above outcomes at long-term follow-up of patients with and without PAD followed in a vascular surgery clinic. Results: At least one of the above outcomes occurred in 259 of 414 patients (63%) with PAD at 33-month follow-up and in 21 of 89 ...
Background: It is controversial about the sex differences in the association of chronic kidney diseases (CKD) and cardiovascular disease (CVD) risk. Thus, we examined CVD risk makers of CKD and non-CKD men and women in China, especially some
Comparability of total cardiovascular disease risk estimates using laboratory and non-laboratory based assessments in urban-dwelling South Africans: The CRIBSA study
The ASPEN did not find a significant reduction in the primary composite end point comparing 10 mg of atorvastatin with placebo (13.7 and 15.0%). However, a 27% reduction in fatal and nonfatal myocardial infarction, although nonsignificant, is comparable to that found in statin cardiovascular end point trials (19). The result for the primary end point differs from the majority of recent studies showing a significant CHD benefit of treating individuals with type 2 diabetes (13-16), with or without prior CHD. The reasons for this result may relate to the overall study design, the types of subjects recruited, the nature of the primary end point, and the protocol changes required because of changing treatment guidelines.. Equivalent CVD rates in diabetic patients without prior CHD and nondiabetic patients with CHD were reported in at least three observational studies (1-4). However, at least four other studies did not report as high a rate of CHD in diabetic patients without CHD (5-8). Therefore, the ...
The ASPEN did not find a significant reduction in the primary composite end point comparing 10 mg of atorvastatin with placebo (13.7 and 15.0%). However, a 27% reduction in fatal and nonfatal myocardial infarction, although nonsignificant, is comparable to that found in statin cardiovascular end point trials (19). The result for the primary end point differs from the majority of recent studies showing a significant CHD benefit of treating individuals with type 2 diabetes (13-16), with or without prior CHD. The reasons for this result may relate to the overall study design, the types of subjects recruited, the nature of the primary end point, and the protocol changes required because of changing treatment guidelines.. Equivalent CVD rates in diabetic patients without prior CHD and nondiabetic patients with CHD were reported in at least three observational studies (1-4). However, at least four other studies did not report as high a rate of CHD in diabetic patients without CHD (5-8). Therefore, the ...
Study documents connection between increased levels of these lipids and cancer growth and metastasis; also opens door to new avenue for cancer treatment. December 19, 2011. Boston, Mass. - A group of small molecules called EETs - currently under scrutiny as possible treatment targets for a host of cardiovascular diseases - may also drive the growth and spread of cancer, according to researchers at the Dana-Farber/Childrens Hospital Cancer Center (DF/CHCC) and other institutions. Their findings also raise the possibility that drugs that block EETs could serve as a new avenue for cancer treatment.. This study, led by Dipak Panigrahy, MD, of DF/CHCC and the Vascular Biology Program at Childrens Hospital Boston, appeared online December 19 in the Journal of Clinical Investigation.. EETs (or epoxyeicosatrienoic acids) are small fatty molecules, part of a larger family of lipids normally produced by the endothelial cells that line blood vessels to control inflammation and the response to injury. ...
The aim of the study was to investigate the effects of rosiglitazone and/or exercise training on novel cardiovascular risk factors in patients with type 2 diabetes mellitus. One hundred overweight/obese type 2 diabetes mellitus patients, with inadequ
Introduction: Current calculators to estimate risk of cardiovascular (CV) disease mortality do not include cardiorespiratory fitness (CRF) or physical activity (PA) measures. This is problematic as CRF is an independent risk factor for CV mortality. To address this issue, Wickramasinghe et al. developed a calculator which includes CRF along with other traditional CV risk factors. The purpose of the present study is to determine the effect of aerobic (AER), resistance (RES) or combination (COMB) exercise training on 30-year CV mortality risk in individuals with type 2 diabetes (T2D).. Methods: The present study is an ancillary analysis of the Health Benefits of Aerobic and Resistance Training Study (HART-D). Adults with type 2 diabetes (T2D) (n=196) were randomized to 9 months of AER, RES, COMB exercise training or a control group (CON). Thirty-year CV mortality risk was evaluated by entering each participants sex, age, blood pressure, smoking status, T2D status, cholesterol, and BMI into a risk ...
The Framingham Risk Score is a gender-specific algorithm used to estimate the 10-year cardiovascular risk of an individual. The Framingham Risk Score was first developed based on data obtained from the Framingham Heart Study, to estimate the 10-year risk of developing coronary heart disease. In order to assess the 10-year cardiovascular disease risk, cerebrovascular events, peripheral artery disease and heart failure were subsequently added as disease outcomes for the 2008 Framingham Risk Score, on top of coronary heart disease. The Framingham Risk Score is one of a number of scoring systems used to determine an individuals chances of developing cardiovascular disease. A number of these scoring systems are available online. Cardiovascular risk scoring systems give an estimate of the probability that a person will develop cardiovascular disease within a specified amount of time, usually 10 to 30 years. Because they give an indication of the risk of developing cardiovascular disease, they also ...
Cardiovascular disease remains the leading cause of death in America, with well-established and identifiable risk factors. Modifiable risk factors are the primary driver for first cardiovascular event, and risk factor modification has been a significant driver for reduction of cardiovascular death in certain populations in recent decades.1,2 However, there remains significant opportunity to improve clinician and patient participation in evidence-based screening and preventative care. According to registry-based studies, 40-60% of patients with cardiovascular risk factors are non-adherent to at least one key component of primary prevention.3 Among those with established atherothrombotic disease, up to 90% are taking antiplatelet, lipid-lowering or anti-hypertensive therapy. However, fewer than 50% are fully adherent to all medications with a class 1 indication in secondary prevention, which is associated with marked increase in risk for recurrent events and death.4. The Million Hearts Initiative ...
In order to prevent cardiovascular events, it is essential to effectively manage overall risk of cardiovascular disease. However, despite guideline recommendations to this effect, current management of the major, modifiable cardiovascular risk factors such as hypertension and dyslipidemia is disconnected and patient adherence to therapy is poor. This is particularly important for patients with multiple cardiovascular risk factors, who are often prescribed multiple medications. The JEWEL study program investigated the use of single-pill amlodipine/atorvastatin as a strategy to improve management of these patients. The JEWEL program consisted of two 16-week, international, open-label, multicenter, titration-to-goal studies in patients with hypertension and dyslipidemia. The two studies differed based on country of enrollment and certain tertiary endpoints, but the overall designs were very similar. Patients were enrolled from 255 centers across Canada and 13 European countries. The study was designed to
Recent studies in the field demonstrate an increasing impact of cardiovascular disease (CVD) on morbidity and mortality in HIV relative to AIDS-related diagnoses. Studies continue to support an approximately 1.5 to two-fold increased risk of IHD conferred by HIV, with specific risk varying by sex and virologic/immunologic status. Risk factors include both traditional CVD risk factors and novel, HIV-specific factors including inflammation and immune activation. Specific antiretroviral therapy (ART) drugs may increase CVD risk, yet the net effect of ART with viral suppression is beneficial with regard to CVD risk. Management of cardiovascular risk and prevention of CVD is complex, because current general population strategies target traditional CVD risk factors only. Extensive investigation is being directed at developing tailored CVD risk prediction algorithms and interventions to reduce CVD risk in HIV.. SUMMARY ...
TY - JOUR. T1 - Nutrition and physical activity interventions to reduce cardiovascular disease risk in health care settings. T2 - A quantitative review with a focus on women. AU - Wilcox, S.. AU - Parra-Medina, D.. AU - Thompson-Robinson, M.. AU - Will, J.. PY - 2001/1/1. Y1 - 2001/1/1. N2 - The authors conducted a quantitative literature review of the impact of 32 diet and physical activity (PA) interventions delivered in health care settings on cardiovascular disease risk factors. Intervention effects were relatively modest but statistically significant for PA, body mass index or weight, dietary fat, blood pressure, and total and low-density lipoprotein serum cholesterol. Intervention effects were generally larger for samples with a mean age ,50 years and for studies with ,6 months follow-up. Type of comparison group, type of intervention, and use of a behavior theory did not have a consistent impact on intervention effects. Few studies focused on persons of color, although the results from ...
Cardiovascular disease is a major health concern affecting over 80,000,000 people in the U.S. alone. Heart failure, cardiomyopathy, heart rhythm disorders, atherosclerosis and aneurysm formation have significant heritable contribution. Supported by familial aggregation and twin studies, these cardiovascular diseases are influenced by genetic variation. Family-based linkage studies and population-based genome-wide association studies (GWAS) have each identified genes and variants important for the pathogenesis of cardiovascular disease. The advent of next generation sequencing has ushered in a new era in the genetic diagnosis of cardiovascular disease, and this is especially evident when considering cardiomyopathy, a leading cause of heart failure. Cardiomyopathy is a genetically heterogeneous disorder characterized by morphologically abnormal heart with abnormal function. Genetic testing for cardiomyopathy employs gene panels, and these panels assess more than 50 genes simultaneously. Despite the large
Results Modelbase indicated that baseline age, smoking, hypertension, high low-density lipoprotein cholesterol (LDL-C), low high-density lipoprotein cholesterol (HDL-C), and diabetes were all significantly associated with plaque progression; the summarised population attributable risk (PAR) was 28.4%. Modelbase + change indicated that status changes in age, hypertension, and high LDL-C were significant; the summarised PAR was 37.9%. Compared with Modelbase, Modelbase + change exhibited a significant increase in c-statistics (P = 0.001), from 0.668 (95% CI: 0.645-0.691) to 0.688 (95%CI: 0.665-0.710). The NRI was 2.17% (95% CI: 1.29-3.05, P = 0.073) among participants without atherosclerosis progression, and was 6.57% (95% CI: 5.04-8.11, P , 0.001) among those with progression. The summarised NRI was 8.74 (95% CI: 7.51-9.94, P , 0.001). Adverse change in hypertension and elevated LDL-C accelerated atherosclerosis progression, but favourable change in their status failed to slow progression. We ...
Our analysis demonstrates a complex relationship between 10-year total CVD and CVD mortality in the EPIC-Norfolk prospective population study, a large European cohort. Men and women showed a decreasing CVD morbidity/mortality ratio with increasing age, and with a greater ratio for women in all age groups. Thus, our results suggest that the ratios of total CVD/CVD mortality are age-dependent and sex-dependent. Furthermore, only 12.9% of first CVD events were fatal. By focusing on CVD mortality only, the overall burden of CVD is seriously underestimated, leaving large numbers of individuals untreated, despite the fact that their risk of CVD events is substantial.. The ESC prevention guidelines use the 10-year cardiovascular mortality risk predictor SCORE as a decision-making tool in primary prevention.2 ,8 Using SCORE risk charts, clinicians can identify individuals with a high risk (≥5%) of 10-year CVD mortality. Based on data from the FINRISK study, it is suggested that at the level at which ...
Learn - Unit XII: Cardiovascular Problems of the Adult Client - Saunders NCLEX-RN Review - 52 Cardiovascular Problems for Nursing RN faster and easier with Picmonics unforgettable videos, stories, and quizzes! Picmonic is research proven to increase your memory retention and test scores. Start learning today for free!
TY - JOUR. T1 - HOMA insulin sensitivity index and the risk of all-cause mortality and cardiovascular disease events in the general population: The Australian Diabetes, Obesity and Lifestyle Study (AusDiab) study. AU - Barr, Elizabeth. AU - Cameron, Adrian. AU - Balkau, Beverley. AU - Zimmet, Paul. AU - Welborn, Timothy. AU - Tonkin, Andrew. AU - Shaw, Jonathan. PY - 2010/1. Y1 - 2010/1. N2 - Aims/hypothesis: We assessed whether the relationships between insulin sensitivity and all-cause mortality as well as fatal or non-fatal cardiovascular disease (CVD) events are independent of elevated blood glucose, high blood pressure, dyslipidaemia and body composition in individuals without diagnosed diabetes. Methods: Between 1999 and 2000, baseline fasting insulin, glucose and lipids, 2 h plasma glucose, HbA1c, anthropometrics, blood pressure, medication use, smoking and history of CVD were collected from 8,533 adults aged ,35 years from the population-based Australian Diabetes, Obesity and Lifestyle ...
TY - JOUR. T1 - Polyunsaturated fatty acids (PUFAs) levels in patients with cardiovascular diseases (CVDs) with and without depression. AU - Chang, Jane Pei Chen. AU - Chang, Shih Sheng. AU - Yang, Hui Ting. AU - Palani, Mahalakshmi. AU - Chen, Chun Ping. AU - Su, Kuan Pin. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Background: Cardiovascular diseases (CVDs) are commonly comorbid with depression and vice versa. Polyunsaturated fatty acids (PUFAs) have been suggested to mediate in CVDs and depression in cross-sectional and observational studies. With the patients of CVDs, we investigated the role of depression on the effect of PUFAs. Methods: Forty-four patients with CVDs were recruited and assessed with Hamilton depression rating scale (HAMD). Patients CVDs markers were measured by electrocardiogram and their red blood cell (RBC) samples were collected for PUFAs analyses. Results: The data of 44 subjects were analyzed; where 10 participants (23%) with CVDs had moderate or severe depression, defined by ...
TY - JOUR. T1 - What is the predictive value of established risk factors for total and cardiovascular disease mortality when measured before middle age? Pooled analyses of two propsective cohort studies from Scotland. AU - Gray, L. AU - Hart, CL. AU - Smith, D. AU - Batty, GD. AU - Davey Smith, G. PY - 2010/2. Y1 - 2010/2. N2 - Aims To examine the association of physiological, behavioural and social characteristics in pre-middle age with future total and cardiovascular disease (CVD) mortality. Methods and results Risk factor data on 1503 individuals aged 16-35 years at baseline were collected in two prospective cohort studies using standard protocols. Their association with total and CVD mortality ascertained during 40 years of follow-up was summarized using Cox proportional hazards regression. A median follow-up of 39.6 years gave rise to 255 deaths (103 from CVD). In age-adjusted and sex-adjusted analyses, impaired lung function [one standard deviation increases in forced expiratory volume in ...
Altenburg, Teatske M., Rotteveel, Joost, Dunstan, David W., Salmon, Jo and Chinapaw, Mai J. M. 2013, The effect of interrupting prolonged sitting time with short, hourly, moderate-intensity cycling bouts on cardiometabolic risk factors in healthy, young adults, Journal of applied physiology, vol. 115, no. 12, pp. 1751-1756, doi: 10.1152/japplphysiol.00662.2013. ...
BACKGROUND: The relationship between macronutrients and cardiovascular disease and mortality is controversial. Most available data are from European and North American populations where nutrition excess is more likely, so their applicability to other populations is unclear.. METHODS: The Prospective Urban Rural Epidemiology (PURE) study is a large, epidemiological cohort study of individuals aged 35-70 years (enrolled between Jan 1, 2003, and March 31, 2013) in 18 countries with a median follow-up of 7·4 years (IQR 5·3-9·3). Dietary intake of 135 335 individuals was recorded using validated food frequency questionnaires. The primary outcomes were total mortality and major cardiovascular events (fatal cardiovascular disease, non-fatal myocardial infarction, stroke, and heart failure). Secondary outcomes were all myocardial infarctions, stroke, cardiovascular disease mortality, and non-cardiovascular disease mortality. Participants were categorised into quintiles of nutrient intake ...
I would suspect that the different effects of anti-oxidants in healthy and unhealthy individuals may well be attributed to different levels of pro-oxidant activity. Recent studies (e.g. Ristow et.al. 2009) have shown that a certain amount of oxidation as induced by resistant exercise is necessary to trigger the health-promoting effects of physical exercise in humans - huge amounts of anti-oxidants will prevent these efffects. If, on the other hand, the oxidation processes exceed a certain level or are induced by an unhealthy diet, the provision of appropriate amounts of anti-oxidants is obviously beneficial for overall health. It is - as always - a matter of keeping things balanced ...
Traditional cardiovascular risk factors had larger associations with cardiovascular mortality than novel risk factors in elderly persons with chronic kidney disease. Future research should investigate whether aggressive lifestyle intervention in patients with chronic kidney disease can reduce their …
Female cardiovascular patients who are depressed amass up to 53 percent higher costs in cardiovascular health care over five years, according to an article in the Journal of the American College of Cardiology. C. Noel Bairey Merz, M.D., who led the study and is a nationally recognized expert in womens heart disease, is available to provide details on the relationship between depression and cardiovascular costs.
Perk J., De Backer G., Gohlke H., Graham I., Reiner Z., Verschuren WMM., Albus C., Benlian P., Boysen G., Cifkova R., Deaton C., Ebrahim S., Fisher M., Germano G., Hobbs R., Hoes A., Karadeniz S., Mezzani A., Prescott E., Ryden L., Scherer M., Syvänne M., Scholte Op Reimer WJM., Vrints C., Wood D., Zamorano JL., Zannad F., Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice None., European Association for Cardiovascular Prevention and Rehabilitation None ...
Omega-3 oil does not reduce serious cardiovascular events for patients with diabetes mellitus (ASCEND) answers are found in the EE+ POEM Archive powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
AIMS: Body mass index (BMI) and waist circumference (WC) are both predictors of cardiovascular diseases (CVD). We compared absolute risk, hazard ratio (HR), and population attributable risk of nonfatal and fatal CVD for BMI and WC in a large prospective cohort study with an average follow-up of 10 years.. METHODS AND RESULTS: Anthropometric data were measured between 1993 and 1997 in a general population sample of over 20,000 men and women aged 20-65 years in the Netherlands. All risks were adjusted for age and sex. Absolute risk of nonfatal CVD was on average 10 times higher than that of fatal CVD. In obese respondents (BMI ,or=30 kg/m2), relative risk of fatal CVD was four-fold higher [HR=4.0 95% confidence interval (CI)=2.4-6.6], whereas risk of nonfatal CVD was two-fold higher (HR=1.8 95% CI=1.6-2.2) than in normal-weight respondents. Similar associations were observed for WC (,or=88 vs. ,80 cm in women and ,or=102 vs. 94 cm in men). In persons with overweight or obesity (BMI ,or=25 kg/m2), ...
In this issue, 2 articles (5, 6) express widely divergent views regarding the role of CRP in cardiovascular disease risk stratification. Because individuals at greatest risk for disease have the most to gain from medical interventions (7), correctly specifying level of risk is an important clinical task. Both Cook and colleagues (5) and Lloyd-Jones and coworkers (6) investigate whether adding CRP to predictive models could usefully improve the ability of clinicians to target interventions. Lloyd-Jones and coworkers (6), who review the published evidence, show that adding CRP to predictive models containing conventional cardiovascular risk factors leads to minor improvement in measures of discrimination (receiver-operator characteristic curve properties or c-statistics). This finding is in line with the findings of the most recent study on this issue (8). Cook and colleagues (5) argue that these measures of discrimination are not appropriate for evaluating the utility of adding single variables ...
TY - JOUR. T1 - Systematic review of cardiovascular disease in women. T2 - Assessing the risk. AU - Worrall-Carter, Linda. AU - Ski, Chantal. AU - Scruth, Elizabeth. AU - Campbell, Michelle. AU - Page, Karen. PY - 2011/12/1. Y1 - 2011/12/1. N2 - Cardiovascular disease is the number one cause of death for women. In an effort to reduce cardiovascular burden for women, identifying risk factors and increasing awareness of sex differences are fundamental. This systematic review examines cardiovascular disease risk for women. A search of the literature was undertaken using key health databases. Search terms used were cardiovascular disease AND women OR gender. Additional references were manually identified from this literature; 58 articles were reviewed in total. On average, cardiovascular disease presents 10years later in women compared to men. By this time, they are more likely to suffer from more comorbidities, placing them at higher risk. The complexity of cardiovascular disease identification in ...
Background-Fibroblast growth factor-23 (FGF-23) is a phosphate regulatory hormone that directly stimulates left ventricular hypertrophy in experimental models. The role of FGF-23 in cardiovascular disease development in the general population is unclear. We tested associations of FGF-23 with major subclinical and clinical cardiovascular disease outcomes in a large prospective cohort. Methods and Results-We evaluated 6,547 participants from the Multi-Ethnic Study of Atherosclerosis (MESA) who were initially free of cardiovascular disease. We measured serum FGF-23 using the Kainos immunoassay. The MESA measured left ventricular (LV) mass by magnetic resonance imaging, coronary calcium (CAC) by computed tomography, and carotid intima-medial thickness (IMT) by ultrasound. The MESA adjudicated incident heart failure, coronary heart disease, and stoke by medical record review. After adjustment, the highest FGF-23 quartile was associated with an estimated 2.4 gram greater LV mass (95% CI 0.4, 4.5 ...
Adults with late-onset asthma had a significantly increased risk of cardiovascular disease events such as MI, stroke and heart failure compared with those who did not have asthma even after adjusting for age, sex and cardiovascular disease risk factors.
Cardiovascular diseases constitute one of the major causes of disability and death all over the world. Increased mechanisation, Westernisation of lifestyle and genetic factors, coupled with an increase in life expectancy owing to control of infectious diseases, have contributed to its rise in the developing world as well.. Despite remarkable advances in the identification of various risk factors and our enhanced knowledge regarding the aetiopathogenesis of cardiovascular diseases and molecular targeting for drug development, effective drug management of cardiovascular diseases still eludes medical researchers. There continues to be an unmet need for better and safer drugs to treat as well as to prevent cardiovascular diseases. In this regard, it is important to remember that many of the cardiovascular diseases are preventable, either by lifestyle modification and/or by drugs.. The past few decades have witnessed the introduction of a remarkable number of not only new drugs, but also new classes ...
WOODBRIDGE, ON, Oct. 9, 2012/ PRNewswire/- Pivotal Therapeutics Inc., a specialty pharmaceutical company with a focus on cardiovascular disease and overall health, is pleased to announce that the company will be exhibiting at the 2012 Cardiometabolic Health Congress in Boston, MA October 10-13, 2012 Booth #513. The CMHC attracts over 1000 U.S. based practicing clinicians and provides a forum for the most current information on preventing, diagnosing and managing cardiovascular and metabolic disorders.
include being overweight, smoking, diabetes, high cholesterol, and high blood pressure. Digital health interventions include telemedicine, Web-based (Internet) strategies, e-mail, mobile phones, mobile applications, text messaging, and monitoring sensors. These methods have been used to help people monitor their health and change behaviors, reducing their risk for preventable diseases.. ...
TY - JOUR. T1 - County-level hispanic ethnic density and cardiovascular disease mortality. AU - Rodriguez, Fatima. AU - Hu, Jiaqi. AU - Kershaw, Kiarri. AU - Hastings, Katherine G.. AU - López, Lenny. AU - Cullen, Mark R.. AU - Harrington, Robert A.. AU - Palaniappan, Latha P.. N1 - Funding Information: This work was supported by the National Institute on Minority Health and Health Disparities (R01MD007012) and the National Heart, Lung, and Blood Institute (F32HL132396).. PY - 2018/10/1. Y1 - 2018/10/1. N2 - Background Hispanics are the fastest growing ethnic group in the United States, and little is known about how Hispanic ethnic population density impacts cardiovascular disease (CVD) mortality. Methods and Results We examined county-level deaths for Hispanics and non-Hispanic whites from 2003 to 2012 using data from the National Center for Health Statistics Multiple Cause of Death mortality files. Counties with more than 20 Hispanic deaths (n=715) were included in the analyses. CVD deaths ...
Cardiovascular disease- Latest news on Cardiovascular disease, health tips Cardiovascular disease and health news at thehealthsite.com. Stay tuned for latest updates on Cardiovascular disease, health guide,Cardiovascular disease health articles and news, photos, videos.
Cardiovascular diseases (CVDs) are considered to be the predominant reason behind death in the world. of AS initiation and development and find out effective realtors for AS administration recently. 1. Launch Cardiovascular illnesses (CVDs) will be the most common reason behind health loss in the home and overseas, by the actual fact that a lot more than 13 million sufferers expire from CVDs yearly [1]. It is shown that atherosclerosis (AS) is the pivotal pathological basis of CVDs. AS, characterized by formation of atherosclerotic plaques in the KW-6002 inhibition artery intima, could induce lumen stenosis or occlusion, finally leading to the event of CVDs [2]. Thus, in order to reduce the prevalence of life-threatening CVDs, especially ischemic heart disease and stroke, the prevention and treatment of AS are of vital importance. Over the past years, several medicines have been developed as therapeutic providers for While and the representative one is the statin. However, there is evidence ...
Background The presence of pets has been associated with reduction of stress and blood pressure and therefore may reduce the risk of cardiovascular diseases. Methods Relative risks (RR) of all deaths, death due to myocardial infarction (MI), cardiovascular diseases (MI or stroke), and stroke during a 20 year follow-up were determined by Cox proportional hazards analysis for categories of cat or dog ownership among participants after adjustment for potential confounding...
This research quantifies the lag effects and vulnerabilities of temperature effects on cardiovascular disease in Changsha-a subtropical climate zone of China. A Poisson regression model within a distributed lag nonlinear models framework was used to examine the lag effects of cold- and heat-related CVD mortality. The lag effect for heat-related CVD mortality was just 0-3 days. In contrast, we observed a statistically significant association with 10-25 lag days for cold-related CVD mortality. Low temperatures with 0-2 lag days increased the mortality risk for those ≥65 years and females. For all ages, the cumulative effects of cold-related CVD mortality was 6.6% (95% CI: 5.2%-8.2%) for 30 lag days while that of heat-related CVD mortality was 4.9% (95% CI: 2.0%-7.9%) for 3 lag days. We found that in Changsha city, the lag effect of hot temperatures is short while the lag effect of cold temperatures is long. Females and older people were more sensitive to extreme hot and cold temperatures than males and
Ageing exerts differential effects on arterial stiffness and wave reflections. However, the impact of cardiovascular risk factors on arterial stiffness and wave reflections and, particularly, how such effects are influenced by ageing has not been assessed within a single large population, covering a sufficiently wide age range. Therefore, we determined the extent to which age alters the impact of traditional cardiovascular risk factors on arterial stiffness and wave reflections. Aortic stiffness and wave reflections were assessed in 4421 individuals (age range 18 to 92 years). When treated as continuous variables, clinic systolic, diastolic, and pulse pressures and glucose levels were independently associated with stiffness, and, with the exception of diastolic pressure, these associations were more marked in older individuals. In contrast, clinic systolic and diastolic pressures and smoking were independently associated with wave reflections, with stronger associations observed in younger ...
TY - JOUR. T1 - A systematic review and meta-analysis of the effects of supervised exercise therapy on modifiable cardiovascular risk factors in intermittent claudication. AU - Jansen, Sandra C. P.. AU - Hoorweg, Beatrijs B. N.. AU - Hoeks, Sanne E.. AU - van den Houten, Marijn M. L.. AU - Scheltinga, Marc R. M.. AU - Teijink, Joep A. W.. AU - Rouwet, Ellen V.. PY - 2019/4. Y1 - 2019/4. KW - Intermittent claudication. KW - Peripheral artery disease. KW - Supervised exercise therapy. KW - Cardiovascular risk. KW - PERIPHERAL ARTERY-DISEASE. KW - TREADMILL EXERCISE. KW - SECONDARY PREVENTION. KW - ENDOTHELIAL FUNCTION. KW - WALKING ABILITY. KW - OLDER PATIENTS. KW - WEIGHT-LOSS. KW - HEART-RATE. KW - REHABILITATION. KW - STRENGTH. U2 - 10.1016/j.jvs.2018.10.069. DO - 10.1016/j.jvs.2018.10.069. M3 - Review article. VL - 69. SP - 1293-1308.e2. JO - Journal of Vascular Surgery. JF - Journal of Vascular Surgery. SN - 0741-5214. IS - 4. ER - ...
Cardiovascular disease (CVD) is a leading cause of death among homeless people. This study examines CVD risk factors and 30-year CVD risk in a population of homeless individuals with mental illness. CVD risks factors were assessed in 352 homeless individuals with mental illness in Toronto, Canada, at the time of their enrollment in the At Home/Chez Soi Project, a randomized trial of a Housing First intervention. The 30-year risk for CVD (coronary death, myocardial infarction, and fatal or nonfatal stroke) was calculated using published formulas and examined for association with need for mental health services, diagnosis of psychotic disorder, sex, ethnicity, access to a family physician and diagnosis of substance dependence. The 30-year CVD risk for study participants was 24.5 ± 18.4%, more than double the reference normal of 10.1 ± 7.21% (difference = −13.0% 95% CI −16.5% to −9.48%). Univariate analyses revealed 30-year CVD risk was greater among males (OR 3.99, 95% CI 2.47 to 6.56) and those
High tumour burden, delayed diagnosis and history of cardiovascular disease may be associated with carcinoid heart disease Carolina Alves1, Marcell
In this large, representative cohort of very old subjects aged 80 years and older, traditional cardiovascular risk factors did not show an association with all-cause or cardiovascular mortality. This pattern was observed both in subjects with and without cardiovascular disease. The presence of frailty, on the other hand, was able to identify patients at high risk for mortality. However, within the strata of robust and frail subjects, traditional cardiovascular risk factors were not able to further identify patients at risk of mortality. Only a history of cardiovascular disease showed a strong association with mortality in robust subjects.. The current study showed that classic cardiovascular risk factors were not associated with mortality in the oldest old. In the Leiden 85 Plus study, de Ruijter et al. [17] showed that classic risk factors included in the Framingham risk score could not identify patients at risk for cardiovascular mortality. This study was performed on a subpopulation of ...
Download The Portfolio Diet For Cardiovascular Disease Risk Reduction Full Book, Available in PDF, ePub, Tuebl, Textbook and Kindle. Read Online FREE book in a
For your information, a study entitled Adverse effects of fructose on cardiometabolic risk factors and hepatic lipid metabolism in subjects with abdominal obesity was recently published in the Journal of Internal Medicine. The purpose of this study by Taskinen et al. was to determine the effects of fructose on liver fat development, body composition, dietary intake, cardiometabolic risk markers, hepatic de novo lipogenesis, and postprandial responses to a standardized oral fat tolerance test (OFTT).. Seventy-one obese healthy men between the ages of 20 and 65 for the study at four clinical centers (Helsinki, Finland; Naples, Italy; Quebec, Canada; and Gothenburg, Sweden) completed the study. Inclusion criteria included: large waist circumference (,96 cm), body mass index (BMI) between 27 and 40 kg/m2, stable weight over the preceding 3 months, a low-density lipoprotein (LDL) ,4.5 mmol/L, and serum triglycerides (TG) ,5.5 mmol/L. Smoking, excessive alcohol consumption, and diagnoses of type 2 ...
Brittney Jackson. Introduction: Cardiovascular diseases (CVD) are the leading cause of death in the United States and consume a significant amount of healthcare expenditures8. It is well researched and known that gene expression patterns are substantially altered in cardiac hypertrophy, myocardial infarction (MI), and heart failure5. microRNAs (miRNAs) are short non-coding RNAs that can target multiple molecules to regulate proteins and are essential for normal development and physiology of the heart. Dysregulation of these miRNAs is linked to CVD and serve as biomarkers1. Methods: Mice were placed under vigorous physical aerobic exercise including swimming and running 5 days per week for 8-10 weeks following an induced MI2,6. miRNA levels were measured and evaluated in regard to increased or decreased expression and their effect on cardiovascular health. This was accomplished by taking left ventricle samples and homogenizing them in TRIZOL. RNA was isolated and specific miRNAs were analyzed ...
This study investigated the associations between circulating plasma biomarkers, which were previously identified by proteomics or immunohistochemistry experiments in human carotid plaques and adverse cardiovascular outcome in patients undergoing coronary angiography. The prognostic value of the majority of these proteins, including OGN and NGAL/MMP9 complex, for MACE had not yet been investigated. Higher circulating OGN and NGAL/MMP9 complex levels were associated with incident MACE during the first year of follow-up, independently of conventional cardiovascular risk factors. Adding OGN or NGAL/MMP9 to a model containing conventional cardiovascular risk factors improved risk classification and discriminatory ability, although the latter was not statistically significant. These associations with incident MACE and improvements in predictive ability were independent of CRP.. In previous proteomic experiments, we have identified a series of novel potential markers of vulnerable atherosclerotic ...
We use cookies to ensure that we give you the best experience on our website. If you click Continue well assume that you are happy to receive all cookies and you wont see this message again. Click Find out more for information on how to change your cookie settings ...
Background and Rationale Cardiovascular disease is highly prevalent in the kidney transplant population, accounting for approximately 40% of all deaths and significant morbidity. The morbidity and mortality experienced by kidney transplant recipients results from an excess of pre-transplant risk factors that are exacerbated by kidney transplantation along with the development of novel risk factors. Hypertension (HTN) is the most consistent cardiovascular disease risk factor in transplant recipients. The majority of patients with kidney failure have HTN and close to 30,000 individuals annually have HTN as the primary cause of kidney failure. A number of immunosuppressive medications exacerbate HTN after transplantation. Further, there is a clear effect of declining allograft function on cardiovascular disease risk.. A large number of studies have been done in the general population comparing ambulatory blood pressure monitoring (ABPM) to casual, office based and home measures of blood pressure ...
Results Carotid plaque was present in 162 (49.1%) of the Spanish patients. The SCORE and Framingham score were each strongly associated with plaque (P ,0.0001). In predicting plaque presence, the area under the curve (AUC) (SE) of the receiver operator characteristic (ROC) curve for the Framingham score was larger than for the SCORE (0.799 (0.024) versus 0.747 (0.027), P =0.003). The optimal cut-off value and corresponding sensitivity and specificity for the Framingham score and SCORE were 11.0, 64% and 81% and 0.5, 86% and 58%, respectively. Based on optimal cut-off values, a high Framingham score but not SCORE was associated with carotid plaque independent of age, sex, erythrocyte sedimentation rate and C-reactive protein concentrations. Whereas a conventional Framingham score value of ≥20 correctly classified only 25% as being at high CVD risk, this proportion increased to 64% in those with a Framingham score of ,11; the percentage of patients without plaque incorrectly classified as being ...
Background: Job strain is associated with an increased coronary heart disease risk, but few large-scale studies have examined the relationship of this psychosocial characteristic with the biological risk factors that potentially mediate the job strain - heart disease association. Methodology and Principal Findings: We pooled cross-sectional, individual-level data from eight studies comprising 47,045 participants to investigate the association between job strain and the following cardiovascular disease risk factors: diabetes, blood pressure, pulse pressure, lipid fractions, smoking, alcohol consumption, physical inactivity, obesity, and overall cardiovascular disease risk as indexed by the Framingham Risk Score. In age-, sex-, and socioeconomic status-adjusted analyses, compared to those without job strain, people with job strain were more likely to have diabetes (odds ratio 1.29; 95% CI: 1.11-1.51), to smoke (1.14; 1.08-1.20), to be physically inactive (1.34; 1.26-1.41), and to be obese (1.12; ...
Our analysis demonstrates that participants with persistent CAC = 0 had an overall lower cardiovascular risk factor profile. The healthy arterial aging group had a significantly lower level for all of the individual cardiovascular risk factors and a higher level for all of the healthy lifestyle factors, except Mediterranean diet. The absence of traditional CVD risk factors was also associated with persistent CAC = 0 when compared with participants with ≥3 CVD risk factors. However, there was no single modifiable traditional cardiovascular risk factor whose absence was strongly associated with healthy arterial aging. This is similar to a large cross-sectional cohort study of almost 17,000 participants by Boutouyrie et al. (19) in which sex, dyslipidemia, and smoking were not significantly associated with arterial aging, which was classified as an increased central arterial stiffness. In addition, Lehmann et al. (20) found a significant inverse trend between the number of cardiovascular risk ...
OBJECTIVE: Coronary artery fluorine-18-sodium fluoride (F-NaF) uptake reflects coronary artery calcification metabolism and is considered to be an early prognostic marker of coronary heart disease. This study evaluated the relationship between coronary artery F-NaF uptake and cardiovascular risk in healthy adults at low cardiovascular risk. PARTICIPANTS AND METHODS: Study participants ... read more underwent blood pressure measurements, blood analyses, and coronary artery F-NaF PET/CT imaging. In addition, the 10-year risk for the development of cardiovascular disease, on the basis of the Framingham Risk Score, was estimated. Multivariable linear regression evaluated the dependence of coronary artery F-NaF uptake on cardiovascular risk factors. RESULTS: We recruited 89 (47 men, 42 women) healthy adults aged 21-75 years. Female sex (0.34 kBq/ml; P=0.009), age (0.16 kBq/ml per SD; P=0.002), and BMI (0.42 kBq/ml per SD; P,0.001) were independent determinants of increased coronary artery F-NaF ...
All-Cause Mortality and Serious Cardiovascular Events in People with Hip and Knee Osteoarthritis: A Population Based Cohort Study. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Dive into the research topics of Projected impact of polypill use among US adults: Medication use, cardiovascular risk reduction, and side effects. Together they form a unique fingerprint. ...
TY - JOUR. T1 - Positive cardiometabolic health for adults with intellectual disability. T2 - An early intervention framework. AU - Trollor, Julian. AU - Salomon, Carmela. AU - Curtis, Jackie. AU - Watkins, Andrew. AU - Rosenbaum, Simon. AU - Samaras, Katherine. AU - Ward, Philip B.. PY - 2016. Y1 - 2016. N2 - Cardiometabolic morbidity is a significant contributor to the poorer health outcomes experienced by people with intellectual disability (ID). Tailoring cardiometabolic monitoring tools developed for the general population to better fit the altered risk profiles and extra needs of people with ID may help to improve health outcomes. This paper describes a new cardiometabolic monitoring framework designed to address the extra needs of people with ID. The framework was adapted from a generalist guideline after a process of extensive consultation with the original authors and over 30 ID and cardiometabolic experts. In addition to standard cardiometabolic monitoring practice, the framework ...
Cardiovascular disease (CVD) is the major cause of morbidity and mortality in the western world, and patients with diabetes have a 2- to 3-fold greater risk of CVD death than those without. This suggests an interaction between diabetes and other CVD risk factors such as hypertension and dyslipidaemia. The treatment of CVD risk factors in patients with diabetes reduces the incidence of CVD death but macrovascular damage is present in patients prior to the onset of overt diabetes, so the early identification and treatment of patients at risk of diabetes is essential for the primary prevention of CVD. Risk factors for diabetes and CVD are more likely to occur simultaneously than would be expected by chance, and this cluster of disorders is collectively called the metabolic syndrome. Individuals with the metabolic syndrome have an increased risk of CVD prior to the development of impaired glucose tolerance and diabetes, and patients with both the metabolic syndrome and diabetes are at greater risk ...
Neutrophil to lymphocyte ratio (NLR) has been shown to predict occurrence of cardiovascular events in the general population. The aim of our study was to evaluate the role of NLR to predict major cardiovascular disease (CVD) events in HIV-infected subjects. We performed a retrospective cohort study of HIV-infected patients residing in the Local Health Authority (LHA) of Brescia, northern Italy, from 2000 to 2012. The incidence of CVD events in HIV-positive patients was compared with that expected in the general population living in the same area, computing standardized incidence ratios (SIRs). To evaluate the predictive role of NLR, univariate and multivariate Cox regression models were applied, computing hazard ratios (HRs). A total of 3766 HIV-infected patients (mean age 38.1 years, 71.3% males) were included (person-years 28768.6). A total of 134 CVD events occurred in 119 HIV-infected patients. A 2-fold increased risk (SIR 2.02) of CVD was found in HIV-infected patients compared to the ...
Results suggest that HIIT is an effective intervention to improve cardiometabolic health in overweight/obese populations. Specifically, ST-HIIT beneficially influenced WC, VO2 max, fasting glucose and DBP, whereas LT-HIIT was found to beneficially influence WC, % body fat, VO2 max, resting HR, SBP and DBP in overweight/obese populations.. Meta-analysis of ST-HIIT revealed no significant effect on body composition in normal weight populations, whereas too few studies are currently available examining the effect of LT-HIIT in normal weight populations. ST-HIIT reduced WC in overweight/obese populations and LT-HIIT significantly improved WC and % body fat in overweight/obese populations. The average change in WC was 2.13 cm for ST-HIIT and 2.23 cm for LT-HIIT, both above the cut-off value of ,2 cm WC decrease which is suggested to confer improvements in metabolic syndrome risk factors.98 These findings suggest that HIIT is an effective stimulus for reducing body fat levels (even in the absence of ...
The simple assessment of atherosclerotic risk factors is not an accurate tool to predict the risk of cardiovascular disease (CVD) in adults without past history of atherosclerotic disease. Preclinical atherosclerotic increases the global cardiovascular risk and should be evaluated for a better risk stratification. Intima-media thickness (IMT), reduced ankle-brachial pressure index (ABI) and impaired flow mediated dilatation (FMD) are independent markers of multifocal but subclinical atherosclerosis and result associated with an increased rate of cardiovascular events. Multidetector computed tomography (MDCT) may be a useful non-invasive technique to detect silent coronary disease (CAD) in patients with peripheral preclinical atherosclerosis. This ebook outlines preclinical athersclerosis and its markers in clinical practice. The ebook gives simple but clear information for a better stratification of global cardiovascular risk. The text serves as an important guide for medical professionals ...
There were 48.7% of participants in the high risk group (SCORE≥5%), 24.3% aged 45-54 and more than half aged 55-64 years. Nearly a quarter of the sample had a total cardiovascular risk of over 10% (SCORE≥10%), whereas 10.1% of the sample had excessively high cardiovascular risk (SCORE≥15%). In the 65-75 age group, the prevalence of men with excessively high risk was 46.6%, compared with 6.0% in women (P,0.001). Most of the main cardiovascular risk factors were slightly increased or borderline in comparison with clinical thresholds ...
The Joint 2016 European Guidelines on Cardiovascular Disease Prevention in Clinical Practice are published today. In this sixth Guidelines update, experts from 10 Societies have taken into account recently published evidence and now clinicians throughout Europe will be interested to know how they need to modify the advice and treatment they give to their patients. View the Guidelines in full :: Web addenda to the Guidelines. ...
Cardiovascular disease, comprising mainly heart attack and stroke, is Australias greatest health problem. Despite great improvements in death rates in recent decades, cardiovascular disease is still the major cause of death in Australia. Cardiovascular disease also places a heavy burden on society in terms of illness, disability and economic cost. However, there are serious gaps in our knowledge about cardiovascular disease and the groups it affects. This limits our capacity to develop and evaluate cost-effective and equitable strategies for community prevention and treatment. Major health agencies have been concerned about this situation for some time. In 1993 the Cardiovascular Disease Implementation Working Group was established by the Australian Health Ministers Advisory Council to consider information on the state of knowledge and practice related to the prevention and treatment of cardiovascular disease, and to develop a set of goals, targets and strategies based on this knowledge. This ...
OBJECTIVES: The purpose of this study was to examine the association of both a low and a high ankle-brachial index (ABI) with incident cardiovascular events in a multiethnic cohort.. BACKGROUND: Abnormal ABIs, both low and high, are associated with elevated cardiovascular disease (CVD) risk. However, it is unknown whether this association is consistent across different ethnic groups, and whether it is independent of both newer biomarkers and other measures of subclinical atherosclerotic CVD.. METHODS: A total of 6,647 non-Hispanic white, African-American, Hispanic, and Chinese men and women age 45 to 84 years from free-living populations in 6 U.S. field centers and free of clinical CVD at baseline had extensive measures of traditional and newer biomarker risk factors, and measures of subclinical CVD, including the ABI. Incident CVD, defined as coronary disease, stroke, or other atherosclerotic CVD death, was determined over a mean follow-up of 5.3 years.. RESULTS: Both a low (,1.00) and a high ...
Journal of Cardiovascular Medicine is a monthly publication of the Italian Federation of Cardiology. It publishes original research articles, epidemiological studies, new methodological clinical approaches, case reports, design and goals of clinical trials, review articles, points of view, editorials and Images in cardiovascular medicine.. ...
Obesity is a leading cause of preventable death, a growing epidemic, and a major contributor to cardiovascular disease risk and mortality in the U.S. (1-6). Although obesitys adverse effect on cardiovascular disease risk is well established, it is less clear whether obesity predicts adverse outcomes after coronary artery bypass graft (CABG) surgery (7,8).. In addition to its association with traditional cardiovascular factors such as diabetes, hypertension, and dyslipidemia, obesity leads to metabolic changes that precipitate an atherogenic milieu (9). Adipose tissue is a major producer of proinflammatory cytokines and hormones and is thought to induce low-grade systemic inflammation that has been implicated in the pathogenesis of cardiovascular disease (10). Few studies have been able to examine the impact of obesity on atherogenic outcomes after CABG surgery, however. Earlier studies that examined the impact of obesity after CABG surgery have primarily focused on post-operative complications ...
Dartmouth-Hitchcock Concord | Cardiovascular Medicine is a Cardiologist at 253 Pleasant Street, Concord, NH 03301. Wellness.com provides reviews, contact information, driving directions and the phone number for Dartmouth-Hitchcock Concord | Cardiovascular Medicine in Concord, NH.
Background Cardiovascular disease risk increases when lipoprotein metabolism is dysfunctional. We have developed a computational model able to derive indicators of lipoprotein production, lipolysis, and uptake processes from a single lipoprotein profile measurement. This is the first study to investigate whether lipoprotein metabolism indicators can improve cardiovascular risk prediction and therapy management. Methods and Results We calculated lipoprotein metabolism indicators for 1981 subjects (145 cases, 1836 controls) from the Framingham Heart Study offspring cohort in which NMR lipoprotein profiles were measured. We applied a statistical learning algorithm using a support vector machine to select conventional risk factors and lipoprotein metabolism indicators that contributed to predicting risk for general cardiovascular disease. Risk prediction was quantified by the change in the Area-Under-the-ROC-Curve (ΔAUC) and by risk reclassification (Net Reclassification Improvement (NRI) and Integrated
Green spaces such as public parks are increasingly regarded as important correlates of cardiovascular health by the scientific community.1 This is based on mounting evidence not only from small-scale experiments,2 ,3 but also large observational studies.4-6 As a result, there is also rising interest among urban planning and health policy decision makers in the opportunities for constructing and targeting green spaces to make more liveable neighbourhoods that actively promote mental and cardiometabolic health, physical recreation and overall quality of life.7 ,8. A challenge with this wave of optimism, however, is the quality of the observational evidence underpinning it.9 The vast majority of studies have been cross-sectional, which means that putative interventions, such as an increase in the quantity or quality of green space available locally, cannot be rigorously evaluated for their impact on health. Even with multivariate adjustment for income and other factors which determine where a ...
CONTEXT: The value of assessing various emerging lipid-related markers for prediction of first cardiovascular events is debated. OBJECTIVE: To determine whether adding information on apolipoprotein B and apolipoprotein A-I, lipoprotein(a), or lipoprotein-associated phospholipase A2 to total cholesterol and high-density lipoprotein cholesterol (HDL-C) improves cardiovascular disease (CVD) risk prediction. DESIGN, SETTING, AND PARTICIPANTS: Individual records were available for 165,544 participants without baseline CVD in 37 prospective cohorts (calendar years of recruitment: 1968-2007) with up to 15,126 incident fatal or nonfatal CVD outcomes (10,132 CHD and 4994 stroke outcomes) during a median follow-up of 10.4 years (interquartile range, 7.6-14 years). MAIN OUTCOME MEASURES: Discrimination of CVD outcomes and reclassification of participants across predicted 10-year risk categories of low (|10%), intermediate (10%-|20%), and high (≥20%) risk. RESULTS: The addition of information on various lipid
Vegetarian diet and clinical impact on cardiovascular risk factors: a systematic literature review of randomized controlled trials ...
It is well established that hypercholesterolemia is a risk factor for coronary heart disease (CHD), and routine screening is recommended for standard lipids and other major modifiable risk factors, including blood pressure, diabetes, obesity, and lifestyle habits.1 Advances in our understanding of the pathophysiology of CHD have led to the discovery of several nonlipid risk factors that may enhance our ability to identify and manage patients who are most likely to have a future cardiovascular event. Information about a constellation of risk factors provides better predictive power than a single risk factor, but whether novel markers should be added to conventional risk factor screening is debated. Three candidate markers have potential use in practice to alter strategies for the prevention of CHD: C-reactive protein (CRP), homocysteine, and lipoprotein A.. There is increasing recognition that the underpinnings of atherosclerosis involve chronic inflammation and the deposition of cholesterol in ...
Sir, say, A (Framingham scores in type II diabetics), B [Cardiovascular Disease (CVD) risks in type II diabetics] and C (diabetic retinopathy) are three entities and if one wants to correlate B with C by measuring A, then A and B must have undoubted pre-existing correlation. But in the said study, it was admitted There is no longitudinal study from India which can suggest whether the scores underestimate or overestimate the CVD risk among subjects with type II diabetes. It was even not mentioned whether the cross-sectional data obtained in the study were in conformity with the Framingham study or not. Therefore when the standard (Framingham scores) was not standardized (validated) for CVD risks in Indian diabetic population, how can Framingham scores and/or CVD risks be correlated to diabetic retinopathy ...
Purpose of Review: Prolonged sitting (sedentary behavior) has deleterious cardiovascular and metabolic correlates; however, little is known about the associations of too much sitting with all-cause and cardiovascular mortality risk. In addition to the adverse effects of total sitting time, the manner in which it is accumulated has also been postulated to be important for cardiovascular health. Recent Findings: We describe recent evidence from several research papers published in the last 12-18 months, showing deleterious relationships of sedentary behavior with mortality outcomes. We also explore emerging findings on breaking up sedentary time and its potential beneficial impact on cardiovascular health. Summary: Consistent independent associations have been observed between sitting time/sedentary behaviors and elevated all-cause and cardiovascular disease mortality risk. Generally, these associations have persisted following adjustment for physical activity. Furthermore, total sedentary time ...
Certain biomarkers of cardiovascular disease may be risk factors for age-related macular degeneration (AMD), according to Andrew K. Vine, MD, FRCSC, who presented the results of a case-control study during the American Academy of Ophthalmology annual meeting.
Results 5638 patients with RA and no prior CVD were included (mean age: 55.3 (SD: 14.0) years, 76% women). During mean follow-up of 5.8 (SD: 4.4) years, 148 men and 241 women developed a CVD event (10-year cumulative incidence 20.9% and 11.1%, respectively). Men had a higher burden of CVD risk factors, including increased blood pressure, higher total cholesterol and smoking prevalence than women (all p,0.001). Among the traditional CVD risk factors, smoking and hypertension had the highest population attributable risk (PAR) overall and among both sexes, followed by total cholesterol. The PAR for Disease Activity Score and for seropositivity were comparable in magnitude to the PAR for lipids. A total of 70% of CVD events were attributable to all CVD risk factors and RA characteristics combined (separately 49% CVD risk factors and 30% RA characteristics). ...
Cardiovascular disease is largely preventable and is associated with inequalities. Find out our position on shared decision making in the context of cardiovascular risk assessment and management.
This is the first study on children concerning the changes of the cardiovascular risk factor profile in obesity in relation to the degree of weight reduction. In agreement with previous reports,7,8 our study showed that up to two thirds of our obese children already had one or more unfavourable cardiovascular risk factors.. In our sample, a significant improvement of cardiovascular risk factor profile associated with obesity (hypertension, increase in LDL cholesterol and triglycerides, decrease in HDL cholesterol) was shown due to a reduction of SDS-BMI of at least 0.5 over the time period of one year, while a reduction of SDS-BMI below showed no significant improvement except a lowering of LDL cholesterol in the group of children with a reduction of SDS-BMI of at least 0.25. A reduction of LDL cholesterol despite an improvement of other cardiovascular risk factors is probably caused by diet and not due to effective weight loss. Since hypertriglyceridaemia and decreased HDL cholesterol are ...
Principal Investigator: Dugald Seely ND, MS. Co-Investigator: Ryan Bradley ND, MPH. Background: Although cardiovascular disease may be partially preventable through dietary and lifestyle-based interventions, few individuals at risk receive intensive dietary and lifestyle counseling. We performed a randomized controlled trial to evaluate the effectiveness of naturopathic care in reducing the risk of cardiovascular disease.. Methods: We performed a multisite randomized controlled trial of enhanced usual care (usual care plus biometric measurement; control) compared with enhanced usual care plus naturopathic care (hereafter called naturopathic care). Postal workers aged 25-65 years in Toronto, Vancouver and Edmonton, Canada, with an increased risk of cardiovascular disease were invited to participate. Participants in both groups received care by their family physicians.. Those in the naturopathic group also received individualized care (health promotion counseling, nutritional medicine or dietary ...