Tafazzin is a protein that in humans is encoded by the TAZ gene. Tafazzin is highly expressed in cardiac and skeletal muscle. It is involved in the metabolism of cardiolipin. Tafazzin functions as a phospholipid-lysophospholipid transacylase. The mutation of the tafazzin gene is associated with a number of clinical disorders including Barth syndrome (BTHS) (type II 3-Methylglutaconic aciduria), dilated cardiomyopathy (DCM), hypertrophic DCM, endocardial fibroelastosis, and left ventricular noncompaction (LVNC). Tafazzin is responsible for remodeling of a phospholipid cardiolipin (CL), the signature lipid of the mitochondrial inner membrane. As a result, BTHS patients exhibit defects in CL metabolism, including aberrant CL fatty acyl composition, accumulation of monolysocardiolipin (MLCL) and reduced total CL levels. The protein was identified by Italian scientists Silvia Bione et al. in 1996. Owing to the complex procedure required for the identification of tafazzin, the protein was named after ...

Quantitative and qualitative alterations of mitochondrial cardiolipin have been implicated in the pathogenesis of Barth syndrome, an X-linked cardioskeletal myopathy caused by a deficiency in tafazzin, an enzyme in the cardiolipin remodeling pathway. A tafazzin-deficient Drosophila model of Barth syndrome that is characterized by low cardiolipin (CL) concentration, abnormal cardiolipin fatty acyl composition, abnormal mitochondria, and poor motor function has been generated earlier. This study shows that tafazzin deficiency in Drosophila disrupts the final stage of spermatogenesis, spermatid individualization, and causes male sterility. This phenotype can be genetically suppressed by inactivation of the gene encoding a calcium-independent phospholipase A2, iPLA2-VIA, which also prevents cardiolipin depletion/monolysocardiolipin accumulation, although in wild-type flies inactivation of the iPLA2-VIA does not affect the molecular composition of cardiolipin. Furthermore, it was shown that treatment ...

Barth syndrome (BTHS) is an X-linked genetic condition, usually transmitted from mother to son (although there is a relatively high incidence of new mutations in Barth syndrome and one confirmed case report of a female Barth syndrome patient). A mother who is a carrier of a Barth syndrome mutation (the gene is named tafazzin - also called TAZ or G4.5) shows no signs or symptoms of this disorder herself, probably due to skewed X-chromosome inactivation.. There is a 50% chance that a boy born to a female carrier will have Barth syndrome, whereas girls born to a carrier have a 50% risk of being carriers themselves. All daughters of a male with Barth syndrome will be carriers, however no sons will be affected. Because there are proven non-carrier mothers, all mothers of Barth syndrome children should be tested in order to define the genetic risk in each family.. Any male child related through the female line to a Barth syndrome individual should be tested for the disorder, as there can be great ...

Lipids are ubiquitous and serve numerous biological functions; thus lipids have been shown to have great potential as candidates for elucidating biomarkers and pathway perturbations associated with disease. Methods expanding coverage of the lipidome increase the likelihood of biomarker discovery and could lead to more comprehensive understanding of disease etiology. We introduce LipidMatch, an R-based tool for lipid identification for liquid chromatography tandem mass spectrometry workflows. LipidMatch currently has over 250,000 lipid species spanning 56 lipid types contained in in silico fragmentation libraries. Unique fragmentation libraries, compared to other open source software, include oxidized lipids, bile acids, sphingosines, and previously uncharacterized adducts, including ammoniated cardiolipins. LipidMatch uses rule-based identification. For each lipid type, the user can select which fragments must be observed for identification. Rule-based identification allows for correct annotation of

Anticardiolipin antibodies purified from serum from patients with systemic lupus erythematosus (SLE) by cardiolipin micelles were studied for their effects on lymphocytes and neutrophils. At a concentration of 160 micrograms/ml they markedly suppressed the [3H]thymidine incorporation of mononuclear cells stimulated by phytohaemagglutinin (4.9 (SEM 1.9%) of the control) and pokeweed mitogen (26.7 (10.5%) of the control). In addition, anticardiolipin antibodies changed the cell cycle of phytohaemagglutinin stimulated lymphocytes such that the S and G2+M phases were significantly diminished (G0/G1 = 64.62%, S = 20.59%, G2+M = 14.78% in the presence of normal human IgG v G0/G1 = 86.07%, S = 10.32%, G2+M = 3.59% in the presence of anticardiolipin antibodies). The suppression of lymphocyte proliferation by anticardiolipin antibodies was shown not to be caused by an alteration of T cell subpopulations. However, the interleukin 2 receptors on the cell surface and the soluble interleukin 2 receptors in ...

The results of this study show that the synthesis of the inner mitochondrial membrane phospholipid, cardiolipin, is markedly inhibited following infection of human embryonic lung or hamster embryo fibroblast cells with herpes simplex virus type 1 or 2. The synthesis of other phospholipids, i.e., phosphatidylcholine, phosphatidylethanolamine, sphingomyelin, and phosphatidylinositol, is relatively unaffected.

Tafazzin knockdown causes hypertrophy of neonatal cardiac myocytes (34), and mutation of the tafazzin gene causes dilated cardiomyopathy in Barth syndrome (64). Our work with neonatal cardiac fibroblasts (NVFs) showed that tafazzin knockdown increased ROS production, activated MAPKs including p42/44 and p38, stimulated transcriptional and translational factors, which in turn activated cell cycle regulators, and increased DNA and protein synthesis. On the other hand, tafazzin knockdown also decreased intracellular ATP, activated AMPK, and halted the energy-consuming process (i.e., cell proliferation), ultimately resulting in multinucleation, hypertrophy, and enhanced collagen secretion.. Tafazzin plays an important role in de novo cardiolipin synthesis and remodeling in the mitochondria. Tafazzin knockdown leads to reduced cardiolipin, which is consistent with previous studies involving yeast (28), Drosophila (72), and human skin fibroblasts (68). To be consistent with what is reported in mice ...

General Information. There are several laboratory tests that can be undertaken to confirm the diagnosis of Barth syndrome. Finding a tafazzin gene (TAZ, also called G4.5) mutation that clearly disables protein synthesis or function is the most definitive test for Xq28-linked Barth syndrome. In addition, the finding of a severely depressed level of tetralinoleoyl-cardiolipin [Schlame et al (2002)], [Vreken et al (2000)] in platelets, cultured cells, or muscle tissue appears to be specific for Barth syndrome caused by mutations in the tafazzin gene. However, because completion of these tests can take more time than desirable when a child has critical cardiac disease, other laboratory tests, as discussed below, in the appropriate clinical setting can be all but diagnostic of Barth syndrome. Although not all clinicians follow the regulations, it is important to recognize that diagnostic information that is given to a patient or patients family must be provided by a laboratory that has met that ...

Hydrothermal experiments were conducted at ca. 1 to 7000 bars and 700 to 1250 °C in 121 rhyolitic to basaltic systems to determine Cl solubility in silicate melts, i.e., the maximum Cl concentration in melts that are saturated in a hydrosaline liquid with or without an aqueous or aqueous-carbonic vapor. The Cl concentration of melts increases with the Cl contents of the fluid unless the melt coexists with vapor plus hydrosaline liquid at fixed pressure and temperature; this phase assemblage buffers the Cl content of each phase with increasing Cl in the system. The Cl content of fluid(s)-saturated melts is independent of the CO2 concentration of the saline liquid ± vapor with up to 21 wt% CO2 in the fluid(s). The experiments show that Cl dissolution in aluminosilicate melts increases with temperature and pressure. Chlorine solubility is also a function of melt composition; it increases with the molar ([Al1/2+Ca1/2+Mg1/2+Na]/Si) of the melt.. These experimental data have been integrated with ...

Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions ...

Translocation of ions across biological membranes is an essential process of life. It is enabled by membrane proteins and relies on tight integration of these proteins into the lipid bilayer. The tight seal is the prerequisite for the generation of electrochemical proton gradients which are the key to biological energy conversion. It is now generally accepted that specific interactions between individual lipids and proteins are crucial for function and structural integrity of membrane proteins [1,2]. Of special interest is cardiolipin (CL), the signature lipid of mitochondria. CL is essential for the function of respiratory complex III and other mitochondrial membrane proteins and also for the integrity of respiratory supercomplexes. Yet, the molecular mechanisms and underlying structure-function relationships are not understood. Disruption of CL biosynthesis leads to the Barth syndrome. This cardio-skeletal myopathy is caused by mutations in the gene of the acyl transferase tafazzin resulting ...

After obtaining a skin sample from a patient with Barth syndrome, Pu was able to make stem cells from the patients skin cells, which he then turned into heart muscle cells. What was once skin became a beating heart muscle.. Next, Pu worked with Kevin Kit Parkers bioengineering group at the Wyss Institute for Biologically Inspired Engineering to assemble the muscle cells on a tiny, flexible plastic film that instructs the cells to line up and form organized muscle fibers. When the cells are assembled into this heart-on-a-chip format, they are able to work together so their beating bends the plastic film. The amount of force the patients heart muscle generates can be measured by how much the sheet bends with each beat. Comparing a Barth syndrome patients sheet with one from a patient with a normally functioning heart further revealed that the Barth heart muscle cells were very weak compared to normal heart muscle cells. Thus, combining the stem cell and heart-on-a-chip technologies allowed ...

Barth syndrome is a rare genetic condition that mostly affects boys. Main symptoms:Heart muscle weakness (cardiomyopathy)Neutropenia (lack of white blood cells needed to fight bacterial infections).Fatigue and general muscle weakness. Growth/feeding issues Barth Syndrome UK is a well-established ...

Park, C E. and Wenner, C E., Mitochondrial lipids of eld ascites tumor cells. Abstr. (1968). Subject Strain Bibliography 1968. 223 ...

AccessGUDID - ANTI-CARDIOLIPIN IgA (04260157080133)- Anti-Cardiolipin Screen is an ELISA test system for the quantitative measurement of IgA class autoantibodies against cardiolipin in human serum or plasma. This product is intended for professional in vitro diagnostic use only.

혈액투석 환자에서 혈전형성에 의한 동정맥루 폐쇄 (vascualr access occlusion)는 가장 흔한 합병증 중의 하나로 혈관 수술 기술의 발전, 동맥경화증의 치료 및 항 혈소판 제제 사용을 포함한 약물적 치료에도 불구하고 혈액투석 환자 중 입원일수의 5-50% 정도를 차지하는 것으로 되어 있다. Anticardiolipin Antibody(ACA) 와 lupus anticoagulant(LA)는 항 인지질 항체들로 혈관 폐쇄 및 반복적인 유산의 중요한 위험인자로 알려져 있으나 혈액투석 치료를 받는 환자에서의 정확한 양성율 및 동정맥루 폐쇄와의 상관관계에 관해서는 아직 많은 이견이 있는 상태이다. 이에 저자는 이화여자대학교 부속병원에서 유지 혈액투석 중인 환자 50명, 총 68예의 동정맥루 (52 AV fistula, 16 AV grafts)를 대상으로 항 cardiolipin 항체와 루프스 항응고인자를 측정하고 병력 및 임상 기록 검토를 통해 이러한 ...

The CLSA webinar series features online lectures from new, mid-career, and established health researchers who are interested in aging. The CLSA webinars provide a forum to discuss the latest health and aging research. Some examples of lecture topics include aging research and policy development, aging and medication use, and aging in the workforce. The webinars are held monthly from September to June, run for one hour, and provide an opportunity for audience questions at the end of the talk.. Please join us for the following presentations of the 2020-2021 CLSA webinar series: Date: Wednesday, January 27, ...

1. The [32P]phosphate incorporated into the phospholipids of isolated rat hepatic cells is present in phosphatidic acid and to a smaller extent in phosphatidylinositol. 2. The ability to synthesize nitrogen-containing phospholipids is restored by adding a liver supernatant fraction, and it is suggested that the metabolic deficiency is caused by the leakage of cytoplasmic enzymes of the synthetase system from the cells. 3. Fortified cell preparations were pulse-labelled with [32P]phosphate, [Me-14C]choline, [2-14C]ethanolamine and [U-14C]inositol and the subsequent fate of the labelled microsomal and mitochondrial phospholipids followed. 4. A fall in the specific radioactivity of microsomal phospholipids and a rise in that of mitochondrial phospholipids is interpreted as providing evidence of a transfer of labelled phospholipid molecules from the synthetic site (endoplasmic reticulum) to the mitochondrial membranes in the intact cells. 5. The formation of the phospholipids of mitochondrial ...

Quality Cardiolipin ELISA kit from ELISA kits manufacturer and elisa kits supplier: Cardiolipin ELISA kit. Our kits are FDA, CE and ISO certified.

Quality Cardiolipin ELISA kit from ELISA kits manufacturer and elisa kits suppliers: Cardiolipin IgG ELISA kit. Our kits are FDA-CE and ISO certified.

A Perry, Florida mom is featured in this months edition of Readers Digest for promoting awareness of Barth Syndrome. Her son suffers from the disease that attacks young children.

MILPITAS, Calif. /ePRNews/ Cardiolipin is an important phospholipid present in the inner mitochondrial membrane and constitutes about 20% of its total lipid composition. It is essential for several mitochondrial functions such as electron…

Prinn Panitchpakdi, Country Head for Thailand at CLSA, discusses the armys decision to begin paying almost $5 billion worth of rice subsidies owed to Thai farmers.

This test helps your healthcare provider diagnose clotting disorders and autoimmune diseases. It measures the concentration of antibodies related to a fat molecule in your blood.

This test helps your healthcare provider diagnose clotting disorders and autoimmune diseases. It measures the concentration of antibodies related to a fat molecule in your blood.

The first day of racing at the 2nd edition of Les Voiles de St. Barth dawned with 25 knots of tropical tradewind breeze and showers sweeping over the picturesque French island located midway down the Caribbean chain.

The McCurdy Family (clockwise from left): Steve, Will, Kate, andEliza (photo courtesy of the McCurdy family) For more on the McCurdys and the Barth Syndrome Foundation, tune in to NBCs TODAY show onMonday, February 16. From the day he was born in 1986, Will McCurdy was a bright, engaging, and alert child. Butwhen he [...]

The intestinal epithelial cells (IECs) that line the gut form a robust line of defense against ingested pathogens. We investigated the impact of infection with the enteric pathogen Citrobacter rodentium on mouse IEC metabolism using global proteomic and targeted metabolomics and lipidomics. The major signatures of the infection were upregulation of the sugar transporter Sglt4, aerobic glycolysis, and production of phosphocreatine, which mobilizes cytosolic energy. In contrast, biogenesis of mitochondrial cardiolipins, essential for ATP production, was inhibited, which coincided with increased levels of mucosal O2 and a reduction in colon-associated anaerobic commensals. In addition, IECs responded to infection by activating Srebp2 and the cholesterol biosynthetic pathway. Unexpectedly, infected IECs also upregulated the cholesterol efflux proteins AbcA1, AbcG8, and ApoA1, resulting in higher levels of fecal cholesterol and a bloom of Proteobacteria. These results suggest that C. rodentium ...

Barth Syndrome is the only known Mendelian disorder of cardiolipin remodeling, with characteristic clinical features of cardiomyopathy, skeletal myopathy, and neutropenia. While the primary biochemical defects of reduced mature cardiolipin and increased monolysocardiolipin are well-described, much of the downstream biochemical dysregulation has not been uncovered, and biomarkers are limited. In order to further expand upon the knowledge of the biochemical abnormalities in Barth Syndrome, we analyzed metabolite profiles in plasma from a cohort of individuals with Barth Syndrome compared to age-matched controls via 1H nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry. A clear distinction between metabolite profiles of individuals with Barth Syndrome and controls was observed, and was defined by an array of metabolite classes including amino acids and lipids. Pathway analysis of these discriminating metabolites revealed involvement of mitochondrial and ...

Background: Graves disease is an autoimmune disease, characterized by the presence of antibodies directed to TSH receptor or nearby regions as well as antibodies to double strands DNA (dsDNA) anticardiolipin and nuclear antibodies. This study evaluated anticardiolipin and rheumatoid factor, such as IgA and IgM antibodies in patients with Graves disease. Patients and methods: Anticardiolipin and rheumatoid factor were measured in sera of 84 patients (29 male, 55 female) with evidence of Graves disease and 41 healthy individuals (15 male, 26 female) with negative history of hyperthyroidism and other autoimmune diseases. Results: Mean level of anti cardiolipin antibody (ACLA) in patients and control groups were 0.192±0.11 and 0.087±0.200 optical density (OD) respectively. The level of IgM-Rhematoid factor (IgM-RF) of patients and healthy control groups was the same, whereas the mean IgA-RF levels in patients was significantly lower than control group. Conclusion: Anticardiolipin level in different

Barth syndrome (BTHS), also known as 3-Methylglutaconic aciduria type 2, is an X-linked genetic disorder. The disorder, which affects multiple body systems, has so far been found exclusively in males. It is named after Dutch pediatric neurologist Peter Barth.Wikipedia Rare mutations in the TAZ gene on the X chromosome may lead to Barth syndrome. ...

Identification of cardiolipin as the membrane receptor of mitochondrial creatine kinase and determination of the transverse distribution of cardiolipin accross the inner mitochondrial ...

In patients with BTHS, we found abnormal molecular compositions of several phospholipids, including cardiolipin, phosphatidylcholine, and phosphatidylethanolamine. The data indicate a maldistribution of fatty acids (i.e., fatty acids lost their preference for specific phospholipids). For instance, the characteristic predominance of linoleic acid in cardiolipin was missing in BTHS. Conversely, the content of linoleoyl was increased in phosphatidylcholine and phosphatidylethanolamine. The notion of misdirected fatty acids was consistent with the presumed acyltransferase defect in BTHS. The most striking consequence of this defect was the absence of tetralinoleoyl-cardiolipin, a major molecular species in several control tissues (24). However, the molecular composition of cardiolipin was altered even in lymphoblasts that did not contain any tetralinoleoyl-cardiolipin, suggesting a general impairment of fatty acid trafficking from and to cardiolipin. In phosphatidylcholine and ...

Treatment of Barth Syndrome by CARDIOlipin MANipulation (CARDIOMAN): A randomised placebo controlled pilot trial conducted by the nationally commissioned Barth Syndrome Service. Sponsor: University Hospitals Bristol NHS Foundation Trust. Status: Recruiting. Funding: National Institute for Health Research (NIHR) Efficacy and Mechanism Evaluation (EME) programme and the Barth Syndrome Foundation USA.. Barth syndrome is a rare, life threatening, genetic disease which affects young males. It is caused by abnormal fats (lipids) in the powerhouses of cells (mitochondria) and those who suffer with it often develop heart failure, heart rhythm abnormalities, bacterial infections, poor growth or feeding, weak muscles, developmental delay, severe exercise intolerance, lethargy and fatigue; all of which affect their daily life. Low white blood cell counts occur frequently due to intermittent or persistent reduction in numbers of the neutrophils that are responsible for fighting bacterial infections. This ...

Stealth BioTherapeutics announced that the FDA has granted Fast Track designation for its lead candidate, elamipretide, for the treatment of Barth syndrome.

Earlier in vivo studies of the large protein family were stymied by the number of family members, and in vitro assays were inconclusive. The Newmeyer group has now successfully developed a minimal cell-free membrane model that behaves like mitochondrial outer membranes (OMMs). Adding recombinant Bid and Bax to the membranes allowed the exit of molecules over 100 times bigger than cytochrome c. With further minimalism, the authors showed that Bid and Bax also released large molecules from protein-free liposomes, as long as the liposomes contained cardiolipin, a signature mitochondrial lipid. Thus, Bax, Bid, and cardiolipin seem to be all a cell needs to induce mitochondria to spill their death-inducing guts. That we can permeabilize membranes with Bid and Bax alone means we dont need to invoke any more complicated mechanism, says Newmeyer. ...

2WW = 2-Week Wait 47XXY = Klinefelters Syndrome ACA = Anti-cardiolipin Antibodies ACTH = Adrenal Corticotropic Hormone AF = Aunt Flo (menstruation)...

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What should the goal of cyber defense be? Maybe a big part of it is convincing the opposition that it will be harder to win than they think.

The Carve Designs Womens St. Barth Reversible Bottom provides full coverage, and a shape that works for everyone | JaxGoods.com

Fatty Acids, Lipids, and IsoprenoidsPhospholipidsGlycerolipid and Glycerophospholipid Metabolism in Bacteria Cardiolipin synthetase (EC 2.7.8.-) ...

The CLSA takes great care to check the accuracy and completeness of the alphanumeric data prior to release. However, because of the size of the dataset and the large number of variables, we cannot guarantee the accuracy, completeness or fitness of the data for any particular use. If you have any questions, please contact us via [email protected].. ...

signed by Barth and numbered 145 of 500 copies. Slipcase edges a little worn/faded, o/w sturdy. C1979 GOOD+ HARDCOVER IN SLIPCASE, SPECIAL FIRST EDITION [BARTH, JOHN] {SPINE A BIT FADED/WORN, O/W CLEAN AND BRIGHT} A ...

TY - JOUR. T1 - Elevated anticardiolipin antibodies in a patient with vibration-white-finger, valvular heart disease and psoriatic arthritis. AU - McHugh, N J. AU - Elvins, D M. AU - Ring, E F. PY - 1993/3. Y1 - 1993/3. N2 - We describe a case of irreversible severe vibration-white-finger (VWF) occurring in a male who used a compression-hammer daily at work for a 20-year period. Infra-red thermography following either a cold provocation or a vibratory stress was a sensitive objective method of documenting the condition. Persistent elevation of IgG anticardiolipin antibodies (aCL) was found in his serum and may be a marker of endothelial damage associated with either VWF or the patients coincidental valvular heart disease.. AB - We describe a case of irreversible severe vibration-white-finger (VWF) occurring in a male who used a compression-hammer daily at work for a 20-year period. Infra-red thermography following either a cold provocation or a vibratory stress was a sensitive objective method ...

To the Editor: Misra and colleagues (1) reported an increased incidence of anticardiolipin antibodies in patients with infectious mononucleosis and postulated the existence of cross-reactions between infectious (viral) antigens and cardiolipin. We report here our experience concerning immunologic and biochemical similarities between Pneumocystis carinii organisms and cardiolipin. We observed that in the acquired immunodeficiency syndrome (AIDS), anticardiolipin antibodies occurred almost exclusively among those patients who had active P. carinii pneumonia (2). To test the cross-reactive hypothesis, we did several experiments.. In the first set of experiments, rabbits were immunized with an antigen from P. carinii in Freunds adjuvant prepared according ...

Dietary conditioning of juvenile trout changed the acyl chain composition of mitochondrial phospholipids and the oxidative capacities of muscle mitochondria. Trout were fed three diets differing only in fatty acid (FA) composition. The highly unsaturated 22:6 n-3 (DHA) accounted for 0.4, 14, and 30% of fatty acids in Diets 1, 2 and 3. After 10 weeks of growth, the dietary groups differed markedly in FA composition of mitochondrial phospholipids, with significant dietary effects for virtually all FA. Mean mitochondrial DHA levels were 19, 40 and 33% in trout fed Diets 1, 2 and 3. Mitochondrial oxidative capacities changed with diet, while mitochondrial concentrations of cytochromes and of the adenylate nucleotide translocase (nmol mg(1) protein) did not. Mitochondria from fish fed Diet 1 had higher non-phosphorylating (state 4) rates at 5 degrees C than those fed other diets. When phosphorylating (state 3) rates differed between dietary groups, rates at 5 and 15 degrees C were higher for fish fed the

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505). Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663). Acts as mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration (PubMed:18635542). Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086). In vitro can ...

Our data suggest that subsequent thrombo-occlusive events and death after focal cerebral ischemia may occur sooner and more frequently in patients found to have IgG aCL immunoreactivity ,40 GPL units at the time of their index focal cerebral ischemic event when compared with patients who harbor 10 to 40 GPL at the time of their index event. Therefore GPL ,40 may be an important prognostic marker for subsequent thrombo-occlusive events in patients with index focal cerebral ischemia. Patients with ,40 GPL also appear to have more features of the antiphospholipid syndrome: younger age at onset and more recurrent strokes at the time of diagnosis.21 Furthermore, being in the GPL ,40 group appears to confer a sixfold-increased risk of developing subsequent TIAs only compared with being in the GPL ≤40 group. TIAs do not generally have as equally bad an outcome as ischemic stroke, although many hemispheric TIAs are minor infarcts by persistent subtle signs or neuroimaging abnormalities, and cognitive ...

Lencel; P; Hardouin; P; Magne; D. Do cytokines induce vascular calcification by the mere stimulation of TNAP activity? Med Hypotheses. 2010 Dec;75(6):517-21. IF = 1.1. Fellah; BH; Delorme; B; Sohier; J; Magne; D; Hardouin; P; Layrolle; P. Macrophage and osteoblast responses to biphasic calcium phosphate microparticles. J Biomed Mater Res A. 2010 Jun 15;93(4):1588-95. IF = 3.4. Granjon; T; Maniti; O; Auchli; Y; Dahinden; P; Buchet; R; Marcillat; O; Dimroth; P. Structure-function relations in oxaloacetate decarboxylase complex. Fluorescence and infrared approaches to monitor oxomalonate and Na(+) binding effect. PLoS One. 2010 Jun 3;5(6):e10935. IF = 3.2. Maniti; O; Lecompte; MF; Marcillat; O; Vial; C; Granjon; T. Mitochondrial creatine kinase interaction with cardiolipin-containing biomimetic membranes is a two-step process involving adsorption and insertion. Eur Biophys J. 2010 Nov;39(12):1649-55. IF = 2.2. Gouttenoire; J; Bougault; C; Aubert-Foucher; E; Perrier; E; Ronzière; MC; Sandell; L; ...

TY - JOUR. T1 - Oxygen metabolism in human placenta mitochondria. AU - Bustamante, J.. AU - Ramírez-Vélez, R.. AU - Czerniczyniec, A.. AU - Cicerchia, D.. AU - Aguilar de Plata, A. C.. AU - Lores-Arnaiz, S.. PY - 2014/12. Y1 - 2014/12. N2 - © 2014, Springer Science+Business Media New York.Due to the high metabolic demands of the placental tissue during gestation, we decide to analyzed the mitochondrial bioenergetic functions in the human term placenta. Different mitochondrial morphological parameters, membrane potential and cardiolipin content were determined by flow cytometry. Oxygen uptake, hydrogen peroxide production and cytochrome P450 content, were also measured. Some apoptotic mitochondrial proteins were also analyzed by western blot. Two isolated mitochondrial fractions were observed: large/heavy and small/light with different functional characteristics. Oxygen uptake showed a respiratory control (RC) of 3.4 ± 0.3 for the heavy mitochondria, and 1.1 ± 0.4 for light mitochondria, ...

In the present study, we explored sexual dimorphism of doxorubicin cardiotoxicity and energetic and signaling pathways that could be involved in these differences. Two clinically relevant cumulative doses of doxorubicin, either 14 mg/kg after 7 injections or 8 mg/kg after 4 injections were administrated to investigate sex differences in the cardiotoxicity of doxorubicin. Doxorubicin treatment resulted in sex differences characterized in males by (1) important weight loss and decrease in survival rate, (2) strong alterations of myocardial function, (3) decrease in energy signaling pathways, (4) downregulation of mitochondrial biogenesis, (5) decrease in cardiolipin content, (6) decrease in mitochondrial DNA content, and (7) and alteration of mitochondrial respiration. No sex differences were found for the oxidative stress response or for death markers, whereas mitochondrial dysfunction and mitochondrial protein expression were associated with early cardiotoxicity in males.. Several clinical ...

Wang et al (Nat Med. 2014 May 11. doi: 10.1038/nm.3545.) just published a fascinating set of experiences in which they created a model of a Barth Syndrome cardiac dysfunction by using heart on chip technology. This technology involves using Barth patient derived induced pluripotent stem cell derived cardiomyocytes seeded on micropatterned fibronectin rectangles in order to recapitulate cardiac tissue structure. From these experiments, the authors were able to derive information about sarcomere organization, contractile dysfunction among other relevant parameters. This model, and the success of these experiments, holds great promise in the development of therapies for cardiomyopathy, as well as creating a system in which phenotype/genotype correlations of specific gene mutations can be better understood.. Hilary Vernon, MD PhD. ...

Welcome to The Mitochondrial Phospholipid Research Center a.k.a. The CLAYPOOL Lab in the Department of Physiology at the Johns Hopkins University School of Medicine. We are an eclectic group of scientists who recognize that phospholipids are really, really, really important. Although second in the cell with respect to its lipid synthesizing capacity, the mitochondrion is number one in our hearts. Using biochemical and cell biologic approaches, we seek to comprehensively understand any and all aspects of mitochondrial phospholipid metabolism as it relates to human health and disease. ...

Saha, N.,Kamboh, M.I.,Kelly, L.J.,Ferrell, R.E.,Tay, J.S. (1992). Apolipoprotein H (beta-2-glycoprotein I) polymorphism in Asians.. Human Biology 64 (4) : 617-621. ScholarBank@NUS Repository ...

Free resource for searching and exporting immune epitopes. Includes more than 95% of all published infectious disease, allergy, autoimmune, and transplant epitope data.

Discover Canadas largest research platform on aging and health. The first major data release from the Canadian Longitudinal Study on Aging (CLSA) is underway. Researchers interested in accessing the CLSA platform are invited to visit the DataPreview Portal on the CLSA website for detailed information about the available data and the application process. The CLSA is the most comprehensive study of aging ever undertaken in Canada. The study will follow 50,000 individuals aged 45 to 85 for 20 years, collecting information about their physical, emotional and social health through telephone interviews, in-home interviews and physical assessments. To date, more than 42,000 participants have been recruited.. The CLSA data will enable researchers to investigate the biological and psychological changes that frequently accompany aging, as well as non-medical factors such as social and economic changes. The longitudinal data will also provide opportunities for sound research that will inform decisions to ...

Fluoroquinolones are Mito-Toxic Many articles about how fluoroquinolones damage mitochondria and lead to mitochondrial dysfunction have been published. In Science Translational Medicine,

Das APOH Gen kodiert das Apolipoprotein H, welches die Brücke zwischen Lipidstoffwechsel, Koagulation und Infektabwehr schlägt. Es wurde gefunden, dass einige SNPs eine Bedeutung für die Plasmakonzentration besitzen. Damit könnten sie auch einen Effekt auf die prothombotische Wirkung insbesondere bei Patienten mit Phospholipid-Antikörpern besitzen.. ...

Explore the science and understand more clearly the Apolipoprotein H topic by reading the best articles made from Experts, Scientific and Academics!

Mitochondria do not have IF1 (all mitochondria), and unlike mammals, yeast ones do not have IF3! Also they seem to use mitochondria-specific initiation factor AEP3. Do mammals have AEP3 homologue? Worth checking... To make things more complicated, mitochondria have their own special mRNA-specific factors... and again, there is a catch. Yeast mRNA have long 5 UTRs (untranslated regions), and mammals have short, they basically have leaderless mRNAs (Id love to see a good reference for that! THIS is a little bit out of date...) - therefore I would expect that these mRNA-specific IFs work differently in yeast in mammals. So yeast and mammalian mitochondrial translation seems to have very, very different translational apparatus. Isnt is weird ...

Author: Khopade, A. J. et al.; Genre: Journal Article; Published in Print: 2004; Title: Phase structures of a hydrated anionic phospholipid composition containing cationic dendrimers and pegylated lipids

What all this meant for stock market investors, CLSA said, was that old reliable names and upcoming companies would be the ones investors should own. By sector, it said conglomerates, banks, construction and infrastructure firms would likely outperform.. CLSA has recommended a conviction buy on Ayala Corp., Metro Pacific Investments Corp., Cebu Air, Philippine National Bank, Security Bank and Robinsons Land Corp.. For specific infrastructure play, CLSA also has buy ratings on construction firms Megawide Corp. and EEI Corp. and a buy rating on Metrobank.. Bonifacio Global City was cited as a microcosm of the change afoot in the broader economy. Fifteen years ago it was a military camp most famous for the incarceration of Sen. [Benigno Ninoy] Aquino. Today, it is home to high offices, luxury residential towers and upmarket shopping centers catering to the emerging middle class, the research said.. The CLSA report also noted that total tourist arrivals hit an all-time high of 3.9 million ...

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August 15, 2012: We consulted with a fertility doctor who specializes in artificial insemination (also called IUI). He ordered a lot of blood work and procedures for me to finish out the diagnosis for my side of things. So far, I know that my estradiol and FSH are good. I also know that I am heterozygous for the MTHFR gene, which is involved with blood clots. That gene puts me at a higher risk for developing blood clots, but it turns out that another of my factors is wonky (will update when I know the name Update: It is the anticardiolipin antibody IGM that is elevated.) is a more significant risk. I also had an x-ray today (8/22) called an HSG. They injected contrast dye into my business and x-rayed to make sure that all my tubes and uterus are open and inviting. Good news--they are. We are still waiting on some of the blood work to come back (including my CF gene testing). Current medications: Prenatal with DHA, Vitamin D, Calcium, MTHFR capsule. Also, he explained why we would need to ...

Lupus circulating anticoagulants are heterogeneous autoantibodies of the IgG and IgM type directly directed against a variety of anionic phospholipids such as cardiolipin, phosphatidylserine or phosphatidylinositol or against proteins having the capacity to bind to phospholipids such as β2-glycoprotein I (β2 -GPI ...

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BSD Medical appoints William S. Barth as Chief Financial Officer and Corporate Secretary. Mr. Barth commenced employment on December 10, 2012 and wil

Our hematology staff suspect auto-immune pathology or vasculitis that is why they asked for ANCA , Anti cardiolipin IgM and IgG which give the following results +ve Anti-cardiolipin IgM and +ve Cytoplasmic ANCA , so and after consultation of DR/Amal el-beshlawy and DR/Samia salah they decide to start methy-prednisolone at low dose 5 mg/kg/day with gradual tapering but without response also…hematuria persist ...

Kit Component:- KN200329G1, HCLS1 gRNA vector 1 in pCas-Guide vector- KN200329G2, HCLS1 gRNA vector 2 in pCas-Guide vector- KN200329D, donor vector…

Among brokerages, CLSA is bullish on Emami while Credit Suisse downgraded steel companies. It downgraded Tata Steel and JSPL to neutral from outperform and JSW Steel to underperform from neutral. Heres a look at the top brokerage calls for today:

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By Espen Barth Eide, Special to CNN Editors note: Espen Barth Eide is managing director of the World Economic Forum. This is the first in a series of articles from the World Economic Forum on the key challenges facing the world in 2015 as part of their Outlook on the Global Agenda.

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TY - JOUR. T1 - On the stereospecificity of microsomal 26-hydroxylation in bile acid biosynthesis.. AU - Gustafsson, J.. AU - Sjöstedt, S.. PY - 1978/1/10. Y1 - 1978/1/10. N2 - The stereospecificity of microsomal 26 -hydroxylation in bile acid biosynthesis was studied. Cholesterol was biosynthesized from [2-14C] mevalonate by a rat liver preparation. The cholesterol was converted stepwise into 3alpha, 7alpha, 12alpha-trihydroxy-5beta-cholestan-26-oic acid by microsomal and soluble fractions of rat liver homogenate. The 3alpha, 7alpha, 12alpha-trihydroxy-5beta-cholestan-26-oic acid was decarboxylated chemically and the carbon dioxide was assayed for 14C. The amount of radioactivity in the liberated carbon dioxide was assayed for 14C. The amount of radioactivity in the liberated carbon dioxide was such as to indicate complete stereospecificity of the microsomal 26 -hydroxylase system. The system hydroxylates the methyl group in position C-26 (the 25-pro-R methyl group) and its ...