Medtronic has received US Food and Drug Administration (FDA) approval for the Claria MRI Quad cardiac resynchronisation therapy defibrillator (CRT-D) SureScan device for patients with heart failure.. The Claria MRI CRT-D is approved for scanning in both 1.5 and 3 Tesla (T) magnetic resonance imaging (MRI) machines, and features EffectivCRT, a new algorithm that automatically tailors the therapy to individual patients by adjusting pacing rates.. "Until now, CRT devices have shown only whether a pacing pulse was sent, but we have not been able to determine if that stimulation actually improves the hearts pumping ability," says Suneet Mittal, director, Electrophysiology Laboratory, Arrhythmia Institute of the Valley Health System, Ridgewood, USA. "With the Claria device, physicians are now able to verify the effectiveness of left ventricular pacing, which is especially beneficial for improving outcomes in patients with atrial fibrillation, who have been difficult to treat because this irregular ...
The focus of this thesis is the development and application of personalised computational models of cardiac electromechanics to understand and ultimately inform cardiac resynchronisation therapy (CRT). To achieve this goal, a semi-automatic pipeline for the generation and parameterisation of detailed biophysically based models using clinical data is presented and applied to a cohort of patients. Specifically, an anatomically based finite element model has been developed and applied to simulate cardiac electromechanics through the coupling of the monodomain and large deformation mechanics governing frameworks. Techniques have been implemented for tting high order representations of cardiac anatomy from MRI data, and myocardial conductivity, sti ness, contractility and boundary conditions from endocardial activation recordings and pressure volume loops respectively. Embedding these tting steps within a semi-automatic pipeline, this personalisation work ow has been applied to four CRT patient data ...
A method and apparatus for selection of one or more ventricular chambers to stimulate for ventricular resynchronization therapy. Intrinsic intracardia electrograms that include QRS complexes, are recorded from a left and right ventricle. A timing relationship between the intrinsic intracardia electrograms recorded from the left and right ventricle is then determined. In one embodiment, the timing relationship is determined using a delay between a left ventricular and a right ventricular sensed intrinsic ventricular depolarizations and a duration interval of one or more QRS complexes. In one embodiment, the duration of QRS complexes is determined from either intracardiac electrograms or from surface ECG recordings. One or more ventricular chambers in which to provide pacing pulses are then selected based on the timing relationship between intrinsic intracardia electrograms recorded from the right and left ventricle, and the duration of one or more QRS complexes.
This study demonstrates that FMD predicts clinical response to CRT, is lower at baseline in non-responders, but that FMD predicts response at 6 and 12 months. There were no significant clinical differences between the responders and non-responders at baseline; all met the current guidelines for CRT implantation. If FMD is used at baseline to discriminate responders from non-responders, then non-responders may not be exposed to potential harms from a device they will ultimately not benefit from.. It is uncertain why responders at baseline should have lower FMD, as while patients with ischaemic cardiomyopathy often have worse endothelial function, it is patients with non-ischaemic cardiomyopathy who typically demonstrate a greater response to CRT.3 ,8 It is possible that differences in endothelial function, are a result of altered haemodynamics, peripheral shear stress, cardiac loading conditions and neurohormonal activation.4 Indeed, there was no significant difference in HF aetiology between ...
Medtronic has treated more than 140,000 heart failure patients with CRT, an implantable heart device that may improve the hearts ability to pump blood.
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Introduction Optimal left ventricular (LV) lead placement via the coronary sinus (CS) is a critical factor in defining response to cardiac resynchronisation therapy (CRT). Using novel semi-automated ... Heart, BCS Abstracts 2011, A Shetty, S Duckett, M Ginks, Y Ma, M Sohal, P Mehta, S Hamid, J Bostock, G Carr-White, K Rhode, R Razavi, C A Rinaldi ...
Introduction Optimal left ventricular (LV) lead placement via the coronary sinus (CS) is a critical factor in defining response to cardiac resynchronisation therapy (CRT). Using novel semi-automated ... Heart, BCS Abstracts 2011, A Shetty, S Duckett, M Ginks, Y Ma, M Sohal, P Mehta, S Hamid, J Bostock, G Carr-White, K Rhode, R Razavi, C A Rinaldi ...
cardiac resynchronisation therapy and non-invasive measurement of cardiac output, heart, heart failure, chest pain, irregular heart, cardiac, cardio-vascular, cardiothoracic, aorta, heart disease, pacemaker, electrophysiology, coronary, angioplasty, stenting
The Evia HF-T and the Entovis HF-T are triple-chamber pacemakers for cardiac resynchronisation therapy (CRT-P). The objective of this study is to prove the safety and efficacy of these pacemakers. In particular, the left ventricular (LV) capture control feature is evaluated, which automatically measures the LV pacing threshold and subsequently adjusts the pacing output ...
www.heartjnl.com. These articles scored the most hits on Hearts website during November 2007. 1 JBS 2: Joint British Societies guidelines on prevention of cardiovascular disease in clinical practice. December 2005;91(suppl V):1-52. (Supplement). 2 Optimal use of echocardiography in cardiac resynchronisation therapy. GB Bleeker, C-M Yu, P Nihoyannopoulos, J de Sutter, N Van de Veire, … ...
B I V E N T R I C U L A R PAC I N G I N PAT I E N T S W I T H H E A R T FA I LU R E A N D I N T R AV E N T R I C U L A R C O N D U C T I O N D E L AY EFFECTS OF MULTISITE BIVENTRICULAR PACING IN PATIENTS WITH HEART FAILURE AND INTRAVENTRICULAR CONDUCTION DELAY SERGE CAZEAU, M.D., CHRISTOPHE LECLERCQ, M.D., THOMAS LAVERGNE, M.D., STUART WALKER, M.D., CHETAN VARMA, M ...
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Soufi, A. and Sawasdichai, A. and Shukla, A. and Noy, P. and Dafforn, T. and Smith, C. and Jayaraman, P.-S. and Gaston, K. (2010) DNA compaction by the higher-order assembly of PRH/Hex homeodomain protein oligomers. Nucleic Acids Research, 38 (21). p. 7513. ISSN 0305-1048. ...
Evidence-based recommendations on implantable cardioverter defibrillators (ICDs) and cardiac resynchronisation therapy (CRT) for arrhythmias and heart failure
Evidence-based recommendations on implantable cardioverter defibrillators (ICDs) and cardiac resynchronisation therapy (CRT) for arrhythmias and heart failure
Comparison of pharmacological treatment alone versus treatment combined with cardiac resynchronization therapy in patients over 75 years. Cruz, Elena; Cortés, Marcelino; Farré, Jerónimo; Palfy, Julia; Ávila, Paloma; Hernández, Ignacio; Romero, Angélica; Benezet, Juan; Franco, Juan; Navas, Miguel; Hernandez, Jose; Briongos, Sem; Rubio, José // Journal of Interventional Cardiac Electrophysiology;Jun2015, Vol. 43 Issue 1, p13 Background: The role of cardiac resynchronization therapy (CRT) in patients aged ≥75 years is not well established. Methods: We identified 607 patients aged ≥75 years with left ventricular ejection fraction (LVEF) of ≤35 %, of whom 78 met the guidelines for indication of CRT.... ...
In cardiac resynchronization therapy (CRT), even if patient selection is made according to Japanese adaptive criteria, there are non-responders. Its main factor is consid..
Cardiac resynchronisation therapy (CRT) with biventricular pacemakers and implantable cardiac defibrillators (ICD) has proven to be a valuable therapy in selected patients with systolic heart failure, ameliorating both morbidity and mortality. However, with current selection criteria and implant technique, about 20 to 30 % of patients remain non-responders. Non-responders might be due to failing selection criteria or methodology in casu echocardiography. However, an important number of non-responders may result of sub-optimal positioning of the left ventricular lead, remote from the site of delayed activation. Endocardial left ventricular stimulation may ameliorate the shortcomings of epicardial stimulation. The advantage of an endocardial approach is the absence of phrenic nerve stimulation which regularly complicates epicardial pacing, a more predictable pacing threshold and much less restriction to position the lead in the area of interest. Transseptal left ventricular endocardial pacing has ...
Name: Dr Munmohan Virdee, specialty: Cardiology , subspecialty: Cardiac devices ,Devices: cardiac resynchronisation therapy device (CRT) ,Devices: dual chamber pacemaker insertion ,Devices: implantable cardioverter defibrillator (ICD) ,Devices: single chamber pacemaker insertion ,Electrophysiology ,Electrophysiology complex cardiac ablation ,Electrophysiology intervention ,Electrophysiology simple cardiac ablation
Name: Dr Trevor Wistow, specialty: Cardiology ,General (internal) medicine , subspecialty: Coronary angiography ,Devices: cardiac resynchronisation therapy device (CRT) ,Devices: dual chamber pacemaker insertion ,Devices: implantable cardioverter defibrillator (ICD) ,Devices: single chamber pacemaker insertion ,Fractional flow reserve (FFR) ,Percutaneous coronary intervention with/without stenting ,Reporting of echocardiography ,Trans-oesophageal echocardiography ,Transthoracic echocardiography
A pacing system computes optimal cardiac resynchronization pacing parameters using intrinsic conduction intervals. In various embodiments, values for atrio-ventricular delay intervals are each computed as a function of an intrinsic atrio-ventricular interval and a parameter reflective of an interventricular conduction delay. Examples of the parameter reflective of the interventricular conduction delay include QRS width and interval between right and left ventricular senses.
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TY - JOUR. T1 - Evaluation of cardiac dyssynchrony with longitudinal strain analysisin 4-chamber cine MR imaging. AU - Kawakubo, Masateru. AU - Nagao, Michinobu. AU - Kumazawa, Seiji. AU - Chishaki, Akiko S.. AU - Mukai, Yasushi. AU - Nakamura, Yasuhiko. AU - Honda, Hiroshi. AU - Morishita, Junji. PY - 2013/12. Y1 - 2013/12. N2 - Purpose: We investigated the clinical performance of evaluation of cardiac mechanical dyssynchrony withlongitudinal strain analysis using four-chamber (4CH) cine magnetic resonance imaging (MRI).Materials and methods: We retrospectively enrolled 73 chronic heart failure patients (41 men, 32 women;mean age, 57 years, NYHA 2, 3, and 4) who underwent a cardiac MRI in the present study. The left ventricu-lar dyssynchrony (LVD) and interventricular dyssynchrony (IVD) indices were calculated by longitudinalstrain analysis using 4CH cine MRI. The LVD and IVD indices were compared by the Wilcoxon rank-sumtest between the patients with indication for cardiac resynchronization ...
Then matters started to get complicated. In addition to a variety of measurements of the onset, peak, and offset of contraction, many individual centers have reported a dozen or more permutations of these measurements with different imaging modalities that could be used to predict responsiveness to CRT.1 This Tower of Babel of markers of mechanical dyssynchrony was compounded by the use of a variety of definitions of procedural success, including clinical evaluation (composite scores, New York Heart Association class, and quality-of-life scores), exercise capacity (10% improvement), and indices of left ventricular (LV) function (,15% reduction of LV volumes, ,5% increase in LV ejection fraction, decrease in Tei index, and reduction of mitral regurgitation). To the astute observer, the fecundity of this field should ring alarm bells: A truly effective modality is unlikely to beget so many variants.. With the publication of the Predictors of Response to CRT (PROSPECT) trial in this issue of ...
Heart Failure clinical trial. Clinical trial for Electrical Activation Mapping Guided Tailor Made Approach for Cardiac Resynchronization Therapy.
A cardiac rhythm management device includes a dual chamber pacemaker especially designed for treating congestive heart failure. The device incorporates a programmed microcontroller which is operative to adjust the pacing mode-AV delay of the pacemaker so as to achieve optimum hemodynamic performance. Atrial cycle lengths measured during transient (immediate) time intervals following a change in the mode-AV delay are signal processed and a determination can then be made as to which particular configuration yields optimum performance.
Process for controlling a double atrial triple chamber pacemaker having a right atrial electrode and a left atrial electrode connected to one and the same atrial circuit for the detection/stimulation of the atrium, as well as a ventricular electrode connected to a ventricular circuit for the detection/stimulation of the ventricle. The control process includes receiving at the input of the atrial circuit and the ventricular circuit a succession of depolarization signals, determining a possibly premature character of the depolarization signal sensed at the input of the atrial circuit, in case of determined prematurity, examining, during the duration of a predetermined window of listening, signals sensed at the input of the ventricular circuit and, in case of a ventricular signal reception, inhibiting all correlated atrial stimulation, and in the absence of sensing a ventricular signal, proceeding to an atrial stimulation at both atria at the end of the listening window duration, and, in the case of no
Supplier: Euro-pharmacies,EuropeChemical Name:SomatropinumComes In: 40IU dual chamber(13.2 mg) / 1 ml water solutionDosage: Men 2-6IU total dailyActive time: Varies by injection methodClass:Growth Hormone Shipping from Europe
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Were back from AcadeCon again. And once again, it was a blast, and this time I didnt end up giving myself con-crud. I want to run down a handful of highlights: Highlight #1: Running a one-shot for the second time. Read More …. ...
Global Cardiac Resynchronization Therapy Device Market Professional Survey Report 2017" Purchase This Report by calling ResearchnReports.com at +1-888-631-6977.. The latest intelligence on the Cardiac Resynchronization Therapy Device market is available in the Global Cardiac Resynchronization Therapy Device Market Research report. This report is a culmination of the key events from last decade to present day, and helps to formulate the best strategy catered to both established market players and new entrants.. A birds eye view of the Cardiac Resynchronization Therapy Device industry made available in the report helps readers to understand the key drivers, restraints, challenges, and opportunities that are shaping the global Cardiac Resynchronization Therapy Device market. Furthermore, the report evaluates challenges experienced from buyers and sellers side. The report offers advice from key industry experts on how these challenges can be overcome.. A major chunk of the report talks about the ...
TY - JOUR. T1 - Association of corrected QT dispersion with symptoms improvement in patients receiving cardiac resynchronization therapy. AU - Hina, Kazuyoshi. AU - Kawamura, Hiroshi. AU - Murakami, Takashi. AU - Yamamoto, Keizo. AU - Yamaji, Hirosuke. AU - Murakami, Masaaki. AU - Hirohata, Satoshi. AU - Ogawa, Hiroko. AU - Sakane, Kohsuke. AU - Kusachi, Shozo. PY - 2008. Y1 - 2008. N2 - Cardiac resynchronization therapy (CRT) is theoretically expected to affect repolarization as well as depolarization. We studied the effects of CRT on corrected QT (QTc) dispersion in association with symptomatic improvement. QTc dispersion was analyzed in 26 consecutive patients (67 ± 6 years old, 18 men and 8 women) who underwent CRT. CRT responders and nonresponders were defined as patients showing and not showing ≥1 class New York Heart Association symptomatic improvement 3 months after CRT, respectively. QTc interval, QRS width, and QTc dispersion were measured automatically from digital data using an ...
Cardiac-resynchronization therapy (CRT) has known benefits in patients with severe left ventricular systolic dysfunction and prolonged QRS duration (,120 ms). However, up to half of patients with systolic dysfunction appear to have left ventricular dyssynchrony by echocardiographic measures, despite a QRS duration of less than 120 ms. As a result, CRT is often used for patients with echocardiographic evidence of dyssynchrony and a narrow QRS complex, despite a lack of clear benefit to this approach. The Echocardiography Guided Cardiac Resynchronization Therapy (EchoCRT) study sought to determine the effect of CRT on patient outcomes in the setting of symptomatic heart failure, echocardiographic findings of dyssynchrony, and QRS duration ,120 ms.. In this multicenter double blind trial, patients with severe symptomatic left ventricular failure (EF,35% and NYHA class III or IV) with a QRS duration of ,130ms (mean 105ms) and evidence of dyssynchrony either on tissue Doppler or speckle tracking echo ...
Considerable proportion of patients does not respond to the cardiac resynchronization therapy (CRT). This study investigated clinical relevance of left ventricular electrode local electrogram delay from the beginning of QRS (QLV). We hypothesized that longer QLV indicating more optimal lead placement in the late activated regions is associated with the higher probability of positive CRT response. We conducted a retrospective, single-centre analysis of 161 consecutive patients with heart failure and LBBB or nonspecific intraventricular conduction delay (IVCD) treated with CRT. We routinely intend to implant the LV lead in a region with long QLV. Clinical response to CRT, left ventricular (LV) reverse remodelling (i.e. decrease in LV end-systolic diameter - LVESD ≥10%) and reduction in plasma level of NT-proBNP |30% at 12-month post-implant were the study endpoints. We analyzed association between pre-implant variables and the study endpoints. Clinical CRT response rate reached 58%, 84% and 92% in the
Umme Habiba Ferdaushi abstract presented on Short term outcome of cardiac resynchronization therapy on functional recovery of patients with congestive heart failure in Bangladeshi population at Euro Heart Failure 2017 | Conferenceseries Ltd
Introduction In selecting patients that may benefit from cardiac resynchronization therapy (CRT), dyssynchrony assessment by echocardiography based only upon the timing of regional contraction is limited by being inherently independent of underlying myocardial contractility. We hypothesised that patient selection may be enhanced using a strain-based parameter based not only on the timing of myocardial segmental motion, but also on the amplitude of contraction, a potential measure of contractile reserve. We assessed a combined early and late strain index (ELSI) to predict CRT response.. Methods Speckle tracking radial strain was performed in 42 patients scheduled for CRT (age 69 +/− 9 years, ischemic 56%, QRS 154 +/− 12ms, NYHA III/IV - 38/4, ejection fraction 23 +/− 7%). The ELSI was calculated as the sum, for each of the 12 non apical segments, of the difference in peak radial strain and strain at aortic valve closure. CRT response was defined as a ,15% reduction in LV end systolic volume ...
AIMS: Cardiac resynchronization therapy (CRT) has reportedly not been effective in the absence of electrical or mechanical dyssynchrony. We present six patients with severe left ventricular (LV) dilation, mitral regurgitation (MR), and non-ischaemic
Haemodynamic and functional effects of cardiac resynchronization therapy (CRT) have been studied mostly at rest. CRT effects on left ventricular (LV) dyssynchrony and function during stress have not been evaluated in detail. We studied the elec
Heart failure patients with a condition called heart block derive significant benefit from cardiac resynchronization therapy (CRT), according to the results of the Block HF clinical trial, presented at the American Heart Association Scientific Sessions 2012 meeting in Los Angeles. Anne B. Curtis, MD, Charles and Mary Bauer Professor and Chair of Medicine in the University at Buffalo School of Medicine and Biomedical Sciences is principal investigator of Block HF.
Cardiac Resynchronization Therapy (CRT), also referred to as biventricular pacing, is often recommended for patients with severe heart dysfunction and congestive heart failure (CHF). Learn more.
The study of the Cardiac Resynchronization Therapy (CRT) Devices Market provides the market size information and market trends along with the factors an
Chalil, Shajil, Foley, Paul W X, Muyhaldeen, Sarkaw A, Patel, Kiran C R, Yousef, Zaheer R, Smith, Russell E A, Frenneaux, Michael P and Leyva, Francisco (2007) Late gadolinium enhancement-cardiovascular magnetic resonance as a predictor of response to cardiac resynchronization therapy in patients with ischaemic cardiomyopathy. EP-Europace, 9 (11). pp. 1031-7. ISSN 1099-5129 Full text not available from this repository. (Request a copy ...
|p|​Find out the key features and specifications for 13 cardiac resynchronization therapy pacemakers (CRT-Ps) from Biotronik, Boston Scientific, Medtronic, and St. Jude. View, analyze, and compare models and features using our downloadable matrix. |/p|
Care guide for Cardiac Resynchronization Therapy (Aftercare Instructions). Includes: possible causes, signs and symptoms, standard treatment options and means of care and support.
Can left bundle branch block cause chest pain? Mammen Ninan, Jonathan W Swan Exercise-induced left bundle branch block usually indicates underlying coronary artery disease or myocardial disease. Association of left bundle branch block (LBBB) with chest pain in the absence of coronary artery disease is rare. We describe the case history of a patient with chest pain associated with left bundle branch block with normal coronary arteries and review the literature on left bundle branch block associated with chest pain.. ...
We expected to see a difference, but we were struck by the magnitude of these results," said Daniel B. Kramer, M.D., M.P.H., lead author of the study and assistant professor of medicine at Harvard Medical School in Boston, Massachusetts.. "Patients functional status clearly predicts survival. Our hope would be to use activity as a factor in not just predicting outcomes but also to guide strategies that may improve outcomes. But that is much further down the line." Researchers studied the ALTITUDE registry, a nationwide database that involved 98,437 patients enrolled in a remote monitoring program. About 57 percent of the patients had received a new or replacement ICD and 43 percent had received cardiac resynchronization therapy cardiac resynchronization therapy (CRT-D) devices in 2008-12. CRT-D therapy combines an ICD with cardiac resynchronization therapy. Patients were followed for a median 2.2 years.. "What is intriguing about our results is that looking at just one piece of information ...
QRS axis -60 Interpretation: Sinus rhythm sensed by a dual chamber pacemaker with ventricular capture. A-V interval 0.19 sec. Normal pacemaker function (atrial sensing, ventricular pacing). The patient complained of dizziness and lightheadedness. Her electrocardigram showed second degree A-V block Mobitz type II, left anterior fascicular block and right bundle branch block. Dual chamber pacemaker (DDDR) has been implanted with resolution of symptoms. << back to ECG Decoder ...
The patients included in this study, who presented with a long history of apparently isolated LBBB and progressive LV dysfunction, possessed the characteristics of an original syndrome suspected from previous animal experiments, epidemiological studies, and clinical observations, though never demonstrated in individual patients. These original observations strongly support the concept of LBBB-induced cardiomyopathy treatable with CRT.. Isolated LBBB causes abnormalities of LV dysfunction, manifest by a shortening of the filling time, a decreased septal contribution to LV ejection, and a globally depressed EF, compared with normal matched controls (5). High-amplitude oscillations of the interventricular septum were also described, similar to the "septal flash," a sign of mechanical dyssynchrony (present in 4 of our 6 patients) and a putative predictor of echocardiographic response to CRT (16).. The clinical value of several techniques and measures proposed to detect and quantify LBBB-induced ...
10. The system of claim 1, wherein the processor is configured to control the electrical stimulation module to deliver the pacing stimulus to the first ventricle by at least: detecting a first atrial pace or sense event; and controlling the electrical stimulation module to deliver a first pacing stimulus after expiration of a first pacing interval from the first atrial pace or sense event, and wherein the processor is configured to determine whether the surrogate indication of intrinsic conduction from the atrium of the heart to the second ventricle of the heart of the patient is detected by at least: detecting, based on electrical cardiac activity sensed by the sensing module, a first activation of the second ventricle within the predetermined window of time immediately following delivery of the first pacing stimulus to the first ventricle; determining a first time interval between the first atrial pace or sense event and the first activation of the second ventricle and a second time interval ...