Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma Recurrent Metastatic Squamous Neck Cancer With Occult Primary Recurrent Salivary Gland Cancer Recurrent Squamous Cell Carcinoma of the Hypopharynx Recurrent Squamous Cell Carcinoma of the Larynx Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity Recurrent Squamous Cell Carcinoma of the Nasopharynx Recurrent Squamous Cell Carcinoma of the Oropharynx Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Recurrent Verrucous Carcinoma of the Larynx Recurrent Verrucous Carcinoma of the Oral Cavity Salivary Gland Squamous Cell Carcinoma Stage III Salivary Gland Cancer Stage III Squamous Cell Carcinoma of the Hypopharynx Stage III Squamous Cell Carcinoma of the Larynx Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity Stage III Squamous Cell Carcinoma of the Nasopharynx Stage III Squamous Cell Carcinoma of the Oropharynx Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal ...
Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma Recurrent Metastatic Squamous Neck Cancer With Occult Primary Recurrent Salivary Gland Cancer Recurrent Squamous Cell Carcinoma of the Hypopharynx Recurrent Squamous Cell Carcinoma of the Larynx Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity Recurrent Squamous Cell Carcinoma of the Nasopharynx Recurrent Squamous Cell Carcinoma of the Oropharynx Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Recurrent Verrucous Carcinoma of the Larynx Recurrent Verrucous Carcinoma of the Oral Cavity Salivary Gland Squamous Cell Carcinoma Stage III Salivary Gland Cancer Stage III Squamous Cell Carcinoma of the Hypopharynx Stage III Squamous Cell Carcinoma of the Larynx Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity Stage III Squamous Cell Carcinoma of the Nasopharynx Stage III Squamous Cell Carcinoma of the Oropharynx Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal ...
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Head and neck cancer, including oral squamous cell carcinoma, is the sixth most common cancer worldwide. Although cancer cell invasion and metastasis are crucial for tumor progression, detailed molecular mechanisms underlying the invasion and metastasis of oral squamous cell carcinoma are unclear. Comparison of transcriptional profiles using a cDNA microarray demonstrated that N4BP2L1, a novel oncogene expressed by neural precursor cells, is involved in oral squamous cell carcinoma. Expression of N4BP2L1 in oral squamous cell carcinoma is regulated by activation of miR-448 and is higher than in normal oral mucosa. Knockdown of N4BP2L1 and upregulation of miR-448 significantly reduced the invasive potential of oral squamous cell carcinoma cells. We studied N4BP2L1 expression in 187 cases of oral squamous cell carcinoma and found its overexpression to be significantly associated with nodal metastasis (P = 0.0155) and poor prognosis (P = 0.0136). Expression of miR-448 was found to be inversely associated
Cutaneous Squamous cell Carcinoma (CsCC) - Epidemiology Forecast To 2025 provides an overview of the epidemiology trends of Cutaneous Squamous cell Carcinoma (CsCC) in seven major markets (US, France, Germany, Italy, Spain, UK and Japan). It includes 10 years epidemiology historical and forecasted data of Cutaneous Squamous cell Carcinoma (CsCC) prevalent or incident cases segmented by age, sex and subpopulations. The Report also discusses the prevailing risk factors, disease burden with special emphasis on the unmet medical need associated with the Cutaneous Squamous cell Carcinoma (CsCC). The report is built using data and information sourced from proprietary databases, primary and secondary research and in-house Forecast model analysis by team of industry experts.. The report will help in developing business strategies by understanding the trends shaping and driving the global Cutaneous Squamous cell Carcinoma (CsCC) market. It helps in identifying prevalent patient populations as well as ...
Abstract: ABSTRACT Although many mouse models of lung adenocarcinoma exist, there is no mouse lung squamous cell carcinoma model that has been validated for use in preclinical lung cancer chemoprevention studies. Since most clinical chemoprevention trials of lung cancer are performed in subjects with bronchial dysplasia, development of a lung squamous cell carcinoma mouse model becomes one of the highest priorities. We have shown that lung squamous cell carcinomas can be induced chemically in several strains of mice (Wang et al. 2004) and that green tea polyphenols exhibit a significant efficacy against the development of lung squamous cell carcinomas (preliminary data section). In this proposal, we will use a standardized green tea preparation called Polyphenon E (PE) and its major component, EGCG. The overall objective of this proposal is to determine the efficacy of green tea polyphenols in a mouse lung squamous cell carcinoma model and to determine the molecular mechanism that underlies the ...
Pathology Department, Harvard Medical School, Boston, Massachusetts 02115-5701, USA. We have investigated the functional integrity of the retinoblastoma tumor suppressor pathway in five human squamous cell carcinoma lines. Elevated activity of cyclin-dependent kinase 6 (cdk6), a pRB kinase, was detected in all five squamous cell carcinoma lines. Overexpression of the cdk6 protein was detected in one of the five cell lines. The cdk6-specific inhibitor p18ink4C is expressed and associated with cdk6 in all five squamous cell carcinoma lines. In contrast, only very low levels of p16ink4A were detected in these cell lines. This may contribute to the elevated activity of cdk6 in these lines. Elevated activity of cdk6 may result in hyperphosphorylation of the retinoblastoma protein and, therefore, compromise its negative growth-regulatory activity ...
TY - JOUR. T1 - Primary squamous cell carcinoma of the breast in a young woman - A case report and review of literature. AU - Vidyasagar, M. S.. AU - Fernandes, D. J.. AU - Ramanujam, A. S.. AU - Suresh Rao, D.. AU - Narayan, Ram. PY - 1998/10/1. Y1 - 1998/10/1. N2 - A thirty-four years old woman presented with pure squamous cell carcinoma of the breast, a very rare occurrence in the younger age group. A simple mastectomy with axillary clearance was performed, followed by adjuvant radiotherapy & chemotherapy. The patient is doing well, with no evidence of recurrence thirty months (21/2 years after the treatment. Primary pure squamous cell carcinoma of the breast is a very rare disease. The exact histogenesis still remains obscure. There seems to be no specific prognostic correlation with the morphological characteristics of squamous cell carcinoma of the breast. The clinical behaviour of this tumor is also uncertain. Thus, further study is required to determine whether primary pure squamous cell ...
Treatment of In November 2006, first lady Laura Bush had a small squamous cell carcinoma removed from her shin. Though hers was a high-profile case, it was by no means unique. An estimated 250,000 new cases of squamous cell carcinoma are diagnosed in the United States every year. And though squamous cell carcinoma was once found mainly in older adults, its occurring with increasing frequency in people younger than 40, Mrs. Bushs cancer was caught and treated early. In such cases, squamous cell carcinoma is highly curable and rarely causes further problems. But untreated squamous cell carcinoma can destroy healthy tissue around the tumor, spread to the lymph nodes or other organs, and occasionally prove fatal, Most squamous cell carcinomas result from prolonged exposure to ultraviolet radiation, either from sunlight or from tanning beds or lamps. Avoiding UV light as much as possible is the best protection. Sunscreen is an important part of a sun-safety program, but by itself doesnt completely prevent
Cutaneous squamous cell carcinoma from the head and neck typically metastasize to the lymph nodes of the neck and parotid glands. When a primary is not identified, they are difficult to distinguish from metastases of mucosal origin and primary salivary gland squamous cell carcinoma. UV radiation causes a mutation pattern that predominantly features cytosine to thymine transitions at dipyrimidine sites and has been associated with cutaneous squamous cell carcinoma. In this study, we used whole genome sequencing data from 15 cutaneous squamous cell carcinoma metastases and show that a UV mutation signature is pervasive across the cohort and distinct from mucosal squamous cell carcinoma. The mutational burden was exceptionally high and concentrated in some regions of the genome, especially insulator elements (mean 162 mutations/megabase). We therefore evaluated the likely impact of UV-induced mutations on the dipyrimidine-rich binding site of the main human insulator protein, CCCTC-binding factor, and the
TY - JOUR. T1 - FGFR gene alterations in lung squamous cell carcinoma are potential targets for the multikinase inhibitor nintedanib. AU - Hibi, Masaaki. AU - Kaneda, Hiroyasu. AU - Tanizaki, Junko. AU - Sakai, Kazuko. AU - Togashi, Yosuke. AU - Terashima, Masato. AU - De Velasco, Marco Antonio. AU - Fujita, Yoshihiko. AU - Banno, Eri. AU - Nakamura, Yu. AU - Takeda, Masayuki. AU - Ito, Akihiko. AU - Mitsudomi, Tetsuya. AU - Nakagawa, Kazuhiko. AU - Okamoto, Isamu. AU - Nishio, Kazuto. PY - 2016/11/1. Y1 - 2016/11/1. N2 - Fibroblast growth factor receptor (FGFR) gene alterations are relatively frequent in lung squamous cell carcinoma (LSCC) and are a potential targets for therapy with FGFR inhibitors. However, little is known regarding the clinicopathologic features associated with FGFR alterations. The angiokinase inhibitor nintedanib has shown promising activity in clinical trials for non-small cell lung cancer. We have now applied next-generation sequencing (NGS) to characterize FGFR ...
Squamous cell carcinomas, also known as epidermoid carcinoma are a number of different types of cancer that result from squamous cells. These cells form the surface of the skin lining of hollow organs in the body and line the respiratory and digestive tracts. Common types include: Squamous cell skin cancer: A type of skin cancer Squamous-cell carcinoma of the lung: A type of lung cancer Squamous cell thyroid carcinoma: A type of thyroid cancer Esophageal squamous cell carcinoma: A type of esophageal cancer Despite sharing the name squamous cell carcinoma, the SCCs of different body sites can show differences in their presented symptoms, natural history, prognosis, and response to treatment. Human papillomavirus infection (HPV) has been associated with SCC of the oropharynx, lung, fingers and anogenital region. Ninety percent of cases of head and neck cancer (cancer of the mouth, nasal cavity, nasopharynx, throat and associated structures) are due to squamous cell carcinoma. Primary squamous cell ...
TY - JOUR. T1 - Unraveling the interplay between senescent dermal fibroblasts and cutaneous squamous cell carcinoma cell lines at different stages of tumorigenesis. AU - Toutfaire, Marie. AU - Dumortier, Elise. AU - Fattaccioli, Antoine. AU - Van Steenbrugge, Martine. AU - Proby, Charlotte M.. AU - Debacq-Chainiaux, Florence. PY - 2018/5/1. Y1 - 2018/5/1. N2 - Cutaneous Squamous Cell Carcinoma (cSCC) is the second most common type of non-melanoma skin cancer in white-skinned populations. cSCC is associated with sun exposure and aging, which is concomitant with an accumulation of senescent cells in the skin. The involvement of senescent cells in carcinogenesis has been highlighted in several cancer types and an interaction between cSCC cells and senescent cells is proposed, but still little explored. Tumor-associated effects are mostly attributed to the senescence-associated secretory phenotype (SASP). Here, we compared two in vitro models of senescence, namely replicative senescence and ...
Recurrent squamous cell carcinoma of the skin treated successfully with single agent cetuximab therapy Selcuk Seber,1 Aylin Gonultas,2 Ozlem Ozturk,2 Tarkan Yetisyigit1 1Department of Medical Oncology, Faculty of Medicine, Namik Kemal University, 2Pathology Department, Tekirdag State Hospital, Tekirdag, Turkey Abstract: Recurrent squamous cell carcinoma of the skin is a rare but difficult to treat condition. Frequently, the disease presents itself in elderly patients with poor performance status and bearing many comorbidities, thus the decision to administer systemic chemotherapy becomes difficult to make. In addition, current chemotherapeutic protocols response rates are far from satisfactory. Recently cetuximab, a chimeric antibody against epidermal growth factor receptor, is increasingly being reported as an alternative treatment. We therefore report this case of a recurrent squamous cell carcinoma of the skin in an elderly woman with poor performance status and who had an excellent clinical
Purpose To discuss the expression of S100A4 and E-cad in oral squamous cell carcinoma (OSCC) and their significance.Methods Expression of S100A4 and E-cad was detected by using immunohistochemical SP method in oral squamous cell carcinoma.Correlation between the expression and clinicopathological features was analyzed.Results Expression of S100A4 had positive correlation with lymph node metastasis (P0.05), and no correlation with histological grade(P0.05). Expression of E-cad had positive correlation with histological grade and negative correlation with lymph node metastasis(P0.05). Inverse relationship between S100A4 and E-cad expression was observed in oral squamous cell carcinoma(P0.05).Conclusions E-cad plays an important role in differentiation of OSCC. E-cad and S100A4 is closely related to invasion and metastasis of OSCC. Expression of S100A4 and E-cadherin is significantly associated with tumor progression in oral squamous cell carcinoma,which are valuable markers in predicting biological
Background: Squamous cell carcinoma accounts for 1% of primary thyroid malignancies and is characterized by a rapidly unfavorable outcome. Case presentation: A 64-year-old woman presented with a painless mass in the left neck, coexisting with thyroid goiter. Total thyroidectomy with lymphadenectomy was performed and a primary thyroid squamous cell cancer was confirmed histologically after excluding any other possible primary malignancies. The tumors immunohistochemical profile was explored using a large panel of antibodies. The tumor featured a positive immunoreaction to cytokeratins 7-19 and to squamous cell carcinoma antigen. Low-molecular-weight cytokeratins 5- 6 and epithelial membrane antigen were also expressed. The neoplasms proliferative index (Mib1) was 60%. No immunostaining was detected for cytokeratins 10-20, thyroglobulin, TTF-1, CD5, galectin-3 or p53. Conclusions: This case of primary thyroid squamous cell carcinoma immunohistochemically profiled using a large panel of ...
Squamous cell carcinoma is the commonest Carcinoma in mucosa. Squamous cell carcinoma is a malignant epithelial neoplasm characterized by variable clinical manifestations metastasis. It most common site in the oral cavity is the lip followed by lateral border of the tongue. Squamous cell carcinoma is radiosensitive and chemo sensitive, but surgery remains the main Modality of treatment. Here we report a successfully treated case of squamous cell carcinoma of left maxilla. Patient was a52 year male who had a swelling in the left palatal region for 6 months. Clinical examination revealed anulceroproliferative lesion involving left palate, alveolus region. Left level 1b (submandibular) lymph node was palpable and hard in consistency with no tenderness. The diagnosis of squamous cell carcinoma was made after incisional biopsy. Treatment of wide excision of tumor, associated cervical lymph node dissection by radiotherapy. The prognosis of squamous cell carcinoma maxilla is high when carcinomatous ...
Squamous cell carcinoma is the second most common skin cancer and is increasing at an alarming rate, particularly in the elderly. Squamous cell carcinoma without question is related directly to sun exposure and also to age. The more sun and sunburns you have had and the longer you live the higher your risk of developing squamous cell carcinoma. They often come from precancerous lesions called actinic or solar keratoses which fair-haired, fair-eyed patients suffer from who have had sunburns as a child and have had chronic sun exposure. These red, raw, itchy, sometimes tender scaly spots on the scalp, face, ears, back of the hands and arms can convert to squamous cell carcinoma. Squamous cell carcinoma can also develop on its own and grow rapidly often fooling patients thinking they are bug bites, boils or infected hairs. These types of squamous cell carcinomas can be dangerous; they present as a nodule that hurts, grow rapidly and have between a 5%-25% risk of spreading or becoming metastatic ...
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AIM: To investigate the putative role of human papillomavirus (HPV) infection in the carcinogenesis of esophageal squamous cell carcinoma in China.. METHODS: Twenty-three esophageal squamous cell carcinoma samples and the distal normal epithelium from Shanxi Province, and 25 more esophageal squamous cell carcinoma samples from Anyang city, two areas with a high incidence of esophageal cancer in China, were detected for the existence of HPV-16 DNA by PCR, mRNA in situ hybridization (ISH) and immunohistochemistry (IHC) targeting HPV-16 E6 gene.. RESULTS: There were approximately 64% (31/48) patients having HPV-16 DNA in tumor samples, among them nearly two-thirds (19/31) samples were detected with mRNA expression of HPV-16 E6. However, in the normal esophageal epithelium from cancer patients, the DNA and mRNA of HPV-16 were found with much less rate: 34.7% (8/23) and 26.1% (6/23) respectively. In addition, at protein level detected by IHC assay, 27.1% (13/48) tumor samples had virus oncoprotein E6 ...
TY - JOUR. T1 - p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells. AU - Kang, Sumin. AU - Elf, Shannon. AU - Lythgoe, Katherine. AU - Hitosugi, Taro. AU - Taunton, Jack. AU - Zhou, Wei. AU - Xiong, Li. AU - Wang, Dongsheng. AU - Muller, Susan. AU - Fan, Songqing. AU - Sun, Shi Yong. AU - Marcus, Adam I.. AU - Gu, Ting Lei. AU - Polakiewicz, Roberto D.. AU - Chen, Zhuo. AU - Khuri, Fadlo R.. AU - Shin, Dong M.. AU - Chen, Jing. PY - 2010/4/1. Y1 - 2010/4/1. N2 - Head and neck squamous cell carcinoma (HNSCC) is one of the most common types of human cancer and frequently metastasizes to LNs. Identifying metastasis-promoting factors is of immense clinical interest, as the prognosis for patients with even a single unilateral LN metastasis is extremely poor. Here, we report that p90 ribosomal S6 kinase 2 (RSK2) promotes human HNSCC cell invasion and metastasis. We determined that RSK2 was overexpressed and activated in highly invasive HNSCC ...
TY - JOUR. T1 - Comparison of characteristics of esophageal squamous cell carcinoma associated with head and neck cancer and those with gastric cancer. AU - Kuwano, Hiroyuki. AU - Morita, Masaru. AU - Tsutsui, Shin‐Ichi ‐I. AU - Kido, Yuichiro. AU - Mori, Masaki. AU - Sugimachi, Keizo. PY - 1991/1/1. Y1 - 1991/1/1. N2 - In ongoing reviews of 339 patients with surgically treated primary squamous cell carcinoma, there were 19 (5.6%) with concurrent gastric cancer and 11 (3.2%) with head and neck cancer. The incidences of intra‐esophageal multiple occurrence of esophageal cancer are 27.3% and 26.3% in those with associated head and neck cancer and gastric cancer, respectively, and higher than 7.1% in those without such a concurrent cancer. There was no difference in the clinicopathological characteristics of those with concurrent head and neck and gastric cancers, except for the higher incidence of metachronous occurrence in the former. These findings suggest that, in cases of esophageal ...
Pathogenetically squamous cell skin cancer presented infiltrative growth thorny layer of skin cells.Due to the malignant (uncontrolled) cell proliferation characteristic of atypia and disarray in the tissue.There are two types of squamous cell carcinoma of the skin: the stratum and neorogovevayuschy.The first is characterized by the persistence of abnormal cells have the ability to keratinization that appears horny pearls in the skin.The second type of cancer more malignant atypical cells completely lose the ability to keratinization.. characteristic localization of squamous cell carcinoma - a red border of lips (usually the lower), the vulva, the perianal region.. Squamous cell carcinoma, unlike papilloma characterized by rapid growth, but is also accompanied by inflammation of the surrounding tissue.. Squamous cell carcinoma can be represented by several morphological forms: ulcer, nodular and blyashkoobraznoy.. for ulcerative forms are characteristic saped region, the presence of bloody ...
The squamous cells make up the outer layer of the skin, nose, and mouth. The squamous cell carcinoma arises when the body?s squamous cells become tumorous. Some general presentations include: sun-induced skin cancer, nasal squamous cell carcinoma, oral squamous cell carcinoma, nasal squamous cell carcinoma.
TY - JOUR. T1 - Squamous cell carcinoma of the rectum: The treatment paradigm. AU - Balducci, Mario. AU - Valentini, Vincenzo. AU - Manfrida, Stefania. AU - Meldolesi, Elisa. AU - Musio, D.. AU - De Felice, F.. AU - Gravina, G. L.. AU - Tombolini, V.. PY - 2015. Y1 - 2015. N2 - This study was planned to clarify the optimal treatment for squamous cell carcinoma of the rectum, an histological entity extremely rare.. AB - This study was planned to clarify the optimal treatment for squamous cell carcinoma of the rectum, an histological entity extremely rare.. KW - Aged. KW - Aged, 80 and over. KW - Carcinoma, Squamous Cell. KW - Disease-Free Survival. KW - Female. KW - Follow-Up Studies. KW - Humans. KW - Italy. KW - Male. KW - Middle Aged. KW - Prognosis. KW - Radiochemotherapy. KW - Radiotherapy. KW - Rectal Neoplasms. KW - Rectal cancer. KW - Retrospective Studies. KW - Squamous cell carcinoma. KW - Survival Rate. KW - Aged. KW - Aged, 80 and over. KW - Carcinoma, Squamous Cell. KW - Disease-Free ...
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How is Head and Neck Squamous Cell Carcinoma abbreviated? H-NSCC stands for Head and Neck Squamous Cell Carcinoma. H-NSCC is defined as Head and Neck Squamous Cell Carcinoma rarely.
TY - JOUR. T1 - AIS is an oncogene amplified in squamous cell carcinoma. AU - Hibi, Kenji. AU - Trink, Barry. AU - Patturajan, Meera. AU - Westra, William H.. AU - Caballero, Otávia L.. AU - Hill, David E.. AU - Ratovitski, Edward A.. AU - Jen, Jin. AU - Sidransky, David. PY - 2000/5/9. Y1 - 2000/5/9. N2 - We and others recently isolated a human p53 homologue (p40/p51/p63/p73L) and localized the gene to the distal long arm of chromosome 3. Here we sought to examine the role of p40/p73L, two variants lacking the N-terminal transactivation domain, in cancer. Fluorescent in situ hybridization (FISH) analysis revealed frequent amplification of this gene locus in primary squamous cell carcinoma of the lung and head and neck cancer cell lines. (We named this locus AIS for amplified in squamous cell carcinoma.) Furthermore, amplification of the AIS locus was accompanied by RNA and protein overexpression of a variant p68(AIS) lacking the terminal transactivation domain. Protein overexpression in ...
Abstract: Cutaneous squamous cell carcinoma (SCC) occurs commonly and can metastasize. Identification of specific molecular aberrations and mechanisms underlying the development and progression of cutaneous SCC may lead to better prognostic and therapeutic approaches and more effective chemoprevention strategies. To identify genetic changes associated with early stages of cutaneous SCC development, we analyzed a series of 40 archived skin tissues ranging from normal skin to invasive SCC. Using high-resolution array-based comparative genomic hybridization, we identified deletions of a region on chromosome 10q harboring the INPP5A gene in 24% of examined SCC tumors. Subsequent validation by immunohistochemistry on an independent sample set of 71 SCC tissues showed reduced INPP5A protein levels in 72% of primary SCC tumors. Decrease in INPP5A protein levels seems to be an early event in SCC development, as it also is observed in 9 of 26 (35%) examined actinic keratoses, the earliest stage in SCC ...
Clinical studies indicate gender bias in cutaneous squamous cell carcinoma (cSCC) incidence with worse prognosis observed in males than in females, suggesting estrogen-mediated protection. In contrast, recent clinical population studies show risk of cSCC by use of oral contraceptives, thus raising controversy. However, animal studies indicate a protective role of estrogen and estrogen receptor (ER)s in cSCC. Currently we have a poor understanding of ERs that are expressed in human cSCC cells and their possible role in malignant transformation. The focus of current study was to determine ER subtype specific expression on cSCC A431 cells and investigate if ER agonist based activation modulates tumor markers CD55 and Cyclin D1 in the cells. ERα, ERβ and G protein-coupled receptor (GPR30) subtype expression at mRNA and protein level was determined in human cSCC A431 cells by reverse transcription-quantitative polym erase chain reaction (RT-qPCR) and Western blotting, respectively. The localization ...
Squamous cell carcinomas account for about 80% of cancers of the uterine cervix, and the majority of the remainder are adenocarcinomas. There is limited evidence on the extent to which these histological types share a common etiology. The International Collaboration of Epidemiological Studies of Cervical Cancer has brought together and combined individual data on 8,097 women with invasive squamous cell carcinoma, 1,374 women with invasive adenocarcinoma and 26,445 women without cervical cancer (controls) from 12 epidemiological studies. Compared to controls, the relative risk of each histological type of invasive cervical cancer was increased with increasing number of sexual partners, younger age at first intercourse, increasing parity, younger age at first full-term pregnancy and increasing duration of oral contraceptive use. Current smoking was associated with a significantly increased risk of squamous cell carcinoma (RR = 1.50, 95% CI: 1.35-1.66) but not of adenocarcinoma (RR = 0.86 (0.70-1.05)), and
Squamous cell carcinomas account for about 80% of cancers of the uterine cervix, and the majority of the remainder are adenocarcinomas. There is limited evidence on the extent to which these histological types share a common etiology. The International Collaboration of Epidemiological Studies of Cervical Cancer has brought together and combined individual data on 8,097 women with invasive squamous cell carcinoma, 1,374 women with invasive adenocarcinoma and 26,445 women without cervical cancer (controls) from 12 epidemiological studies. Compared to controls, the relative risk of each histological type of invasive cervical cancer was increased with increasing number of sexual partners, younger age at first intercourse, increasing parity, younger age at first full-term pregnancy and increasing duration of oral contraceptive use. Current smoking was associated with a significantly increased risk of squamous cell carcinoma (RR = 1.50, 95% CI: 1.35-1.66) but not of adenocarcinoma (RR = 0.86 (0.70-1.05)), and
Semantic Scholar extracted view of Head and neck squamous cell carcinoma cell lines as a model system for the study of oncogene expression during tumor progression and metastasis. by Gary Edward Gallick et al.
An investigation was conducted to assess the incidence and. identify the predisposing factors of bovine squamous cell carcinoma in Kenya. The incidence, breed susceptibility, sites of origin and age distribution of squamous cell carcinoma found in the four breeds of grade cattle in Kenya are reported along with the observed correlation between lack of pigmentation of the bovine vulvae and occurrence of bovine vulva carcinoma. Typical examples of the histology of bovine squamous cell carcinoma which were observed during histological diagnosis are also shown. The data of 18 cattle with vulva carcinoma and 48 cattle with ocular carcinoma on which immunotherapy trials were conducted are reported. The details of the preparation of the saline phenol extract of bovine squamous cell carcinoma used in the study are outlined. The methods by which immunotherapy trials were conducted are described. rIt was found that bovine vulva carcinoma and bovine ocular carcinoma on the eyelid skins did not respond to ...
Squamous cell carcinoma is the most common type of oral cancer, and makes up about 90% of all oral cancer diagnoses. Squamous cells are the flat cells that line the tissues inside your mouth; when these cells become abnormal, squamous cell carcinoma is the result. Heres what you need to know about this condition.. Why does this cancer develop?. Squamous cell carcinoma develops when your cells become abnormal, but why does this happen? There are many reasons. Smoking cigarettes, drinking alcohol, and having HPV infection are considered the main causes, but other things also increase the risk of your cells becoming abnormal. Excessive sun exposure and exposure to x-rays can also cause this type of cancer. You can also develop this cancer without having any of these risk factors since doctors still havent discovered every single cause of cancer. Where can it develop?. Squamous cell carcinoma can affect any of the tissues inside of your mouth. It can form on the inside of your cheeks, on your ...
Head And Neck Cancer Squamous Cell Carcinoma - Pipeline Review, H2 2014SummaryGlobal Markets Directs, Head And Neck Cancer Squamous Cell Carcinoma - Pipeline Review, H2 2014, provides an overview of the Head And Neck Cancer Squamous Cell Carcinomas therapeutic pipeline.This report provides comprehensive information on the therapeutic development for Head And Neck Cancer Squamous Cell Carcinoma, co
Mutations in the tumor suppressor gene TP53 and proto-oncogene PIK3CA and alterations of p53 and PIK3CA AKT mTOR pathways are common events in several human cancers. We focused on the analysis of TP53 and PIK3CA gene variations in adenocarcinoma, squamous cell carcinoma as well as in intraepithelial neoplasia grade 3 of the cervix. DNA samples from 28 cervical adenocarcinoma, 55 squamous cell carcinoma and 31 intraepithelial neoplasia grade 3 (CIN3), previously characterized in terms of human papillomavirus (HPV) prevalence and genotype distribution, were analyzed for TP53 and PIK3CA mutations in the exons 4-9 and exon 9, respectively. Single nucleotide substitutions in TP53 and PIK3CA genes were detected in 36% and 11% of adenocarcinoma, in 16% and in 5% of squamous cell carcinoma, and in 13% and none of CIN 3, respectively. Nucleotide changes in TP53 were significantly more frequent in adenocarcinoma cases than in squamous cell carcinoma and CIN3 (P = 0.035) and were independent from HPV infection
Tonsillar squamous cell carcinoma, which represents 10% of head and neck malignancies, rarely manifests with cutaneous metastases; to date, only three prior patients with tonsillar squamous cell carcinoma have been reported to develop cutaneous metastases. We describe the clinical features of a 59-year-old man with squamous cell carcinoma of the tonsil who developed cutaneous metastases within his prior radiation port and review the literature of prior patients with cutaneous metastases from tonsillar squamous cell carcinoma. The PubMed database was searched for the following keywords: carcinoma, cutaneous, metastasis, squamous, and tonsil. The papers generated by the search and their references were reviewed. Cutaneous metastasis from tonsillar cancer is rare but should be considered in patients with a history of a squamous cell carcinoma of the tonsil; new skin lesions, both overlying the visceral malignancy and at more distant sites, should be biopsied since prognosis in these patients is poor.
Cisplatin is widely used for chemotherapy of head and neck squamous cell carcinoma. However, details of the molecular mechanism responsible for cisplatin resistance are still unclear. The aim of this study was to identify the expression of genes related to cisplatin resistance in oral squamous cell carcinoma cells. A cisplatin-resistant cell line, Tca/cisplatin, was established from a cisplatin-sensitive cell line, Tca8113, which was derived from moderately-differentiated tongue squamous cell carcinoma. Global gene expression in this resistant cell line and its sensitive parent cell line was analyzed using Affymetrix HG-U95Av2 microarrays. Candidate genes involved in DNA repair, the MAP pathway and cell cycle regulation were chosen to validate the microarray analysis results. Cell cycle distribution and apoptosis following cisplatin exposure were also investigated. Cisplatin resistance in Tca/cisplatin cells was stable for two years in cisplatin-free culture medium. The IC50 for cisplatin in Tca
Cisplatin is widely used for chemotherapy of head and neck squamous cell carcinoma. However, details of the molecular mechanism responsible for cisplatin resistance are still unclear. The aim of this study was to identify the expression of genes related to cisplatin resistance in oral squamous cell carcinoma cells. A cisplatin-resistant cell line, Tca/cisplatin, was established from a cisplatin-sensitive cell line, Tca8113, which was derived from moderately-differentiated tongue squamous cell carcinoma. Global gene expression in this resistant cell line and its sensitive parent cell line was analyzed using Affymetrix HG-U95Av2 microarrays. Candidate genes involved in DNA repair, the MAP pathway and cell cycle regulation were chosen to validate the microarray analysis results. Cell cycle distribution and apoptosis following cisplatin exposure were also investigated. Cisplatin resistance in Tca/cisplatin cells was stable for two years in cisplatin-free culture medium. The IC50 for cisplatin in Tca
TY - JOUR. T1 - Malignant Brenner tumor mimicking a primary squamous cell carcinoma of the cervix. AU - Badve, Sunil. AU - Fehmian, C.. AU - Cass, I.. AU - Goldberg, G. L.. AU - Jones, J. G.. PY - 1999/9. Y1 - 1999/9. N2 - An 86-year-old female presented with a necrotic cervical mass that was biopsy-proven squamous cell carcinoma. She had an elevated CA-125 and a pelvic mass. At surgery, this mass was found to be of adnexal origin and contiguous with the cervix. Histology showed a malignant Brenner tumor with abundant squamous differentiation eroding the cervix and simulating a primary cervical malignancy. We describe this case and review the literature on metastatic tumors to the cervix.. AB - An 86-year-old female presented with a necrotic cervical mass that was biopsy-proven squamous cell carcinoma. She had an elevated CA-125 and a pelvic mass. At surgery, this mass was found to be of adnexal origin and contiguous with the cervix. Histology showed a malignant Brenner tumor with abundant ...
TY - JOUR. T1 - Role of Penile Doppler US in the Preoperative Assessment of Penile Squamous Cell Carcinoma Patients. T2 - Results From a Large Prospective Multicenter European Study. AU - Bozzini, Giorgio. AU - Provenzano, Marco. AU - Romero Otero, Javier. AU - Margreiter, Markus. AU - Garcia Cruz, Eduardo. AU - Osmolorskij, Boris. AU - Verze, Paolo. AU - Pavan, Nicola. AU - Sanguedolce, Francesco. AU - Buffi, Nicolò. AU - Ferrucio, Guazzoni Giorgio. AU - Taverna, Gian Luigi. PY - 2016/4/1. Y1 - 2016/4/1. N2 - Objective To determine the role of penile Doppler ultrasound (PDU) compared with magnetic resonance imaging (MRI) in preoperative diagnostic evaluation of patients with penile squamous cell carcinoma. Materials and Methods A prospective analysis on patients presenting with clinical diagnosis of penile squamous cell carcinoma from 6 different European hospitals between 2012 and 2014 was carried out. Each patient who had planned an organ sparing approach underwent an MRI and PDU both with ...
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Background The National Comprehensive Cancer Network guidelines recommend that patients with oral cavity squamous cell carcinoma (OSCC) and cT4b disease should be either included in clinical trials or...
Parikh A., Shin J. H., Faquin W., Lin D. T., Tirosh I., Sunwoo J. B. & Puram S. V. (2020). Malignant cell-specific CXCL14 promotes tumor lymphocyte infiltration in oral cavity squamous cell carcinoma. Journal for ImmunoTherapy of Cancer. 2020, 8 (2). ...
TY - JOUR. T1 - Immunohistochemical expression patterns of the HER4 receptors in normal mucosa and in laryngeal squamous cell carcinomas: Antioncogenic significance of the HER4 protein in laryngeal squamous cell carcinoma. AU - Paludetti, Gaetano. AU - Almadori, Giovanni. AU - Pitocco, Dario. AU - Bussu, Francesco. AU - Ranelletti, Franco Oreste. AU - Gessi, Marco. AU - Graziani, Cristina. AU - Lanza, Paola. AU - Lauriola, Libero. PY - 2012. Y1 - 2012. N2 - OBJECTIVES/HYPOTHESIS.: The prognosis for laryngeal squamous cell carcinoma (LSCC) has not shown any improvement in the last 30 years because of inadequate prognostic stratification. Therefore, the detection of reliable molecular markers may have a significant impact on clinical practice. As promising data regarding HER1/EGFR have been published, the purpose of the present study was to elucidate the role of the other receptors of the HER family. STUDY DESIGN: Retrospective. METHODS.: We used quantitative immunohistochemistry to evaluate the ...
Philippine General Hospital, University of the Philippines Manila. Objective. This study aims to determine the prevalence and pattern of thyroid gland involvement in advanced laryngeal squamous cell carcinoma and to identify factors associated with its development.. Method. Records of 118 patients who underwent laryngectomy with thyroidectomy for advanced laryngeal squamous cell carcinoma in a tertiary government hospital from January 2010 to August 2015 were reviewed. Demographic, clinical and histopathology data were obtained. The relationship of the laterality of primary tumor bulk and lobe involvement was analyzed using Fischers exact test. The association between thyroid gland invasion and other factors was analyzed using logistic regression.. Results. Thyroid gland involvement was found in 11% of the patients via direct spread in 92.3%. Single lobe involvement accounted for 61.5% of cases. There is a tendency for laryngeal squamous cell carcinoma to invade the thyroid lobe ipsilateral to ...
Klotho is known as an anti‑aging gene. We previously reported that the expression of Klotho is a postoperative prognostic factor for patients with lung large cell neuroendocrine carcinoma and lung small cell carcinoma. Recently, Klotho was shown to suppress the epithelial‑mesenchymal transition (EMT). In the present study, we examined the association between the expression of Klotho and the regulation of EMT in lung squamous cell carcinoma. We immunohistochemically examined the expression of Klotho in patients with lung squamous cell carcinoma who had undergone surgical resection or photodynamic therapy. The immunohistochemical analysis showed that Klotho expression was observed not only in normal bronchial epithelial cells, but also in centrally located early lung cancers, which were all carcinomas in situ and were treated using PDT. However, in lung cancer patients with invasive and or advanced squamous cell carcinoma who had undergone a complete surgical resection, Klotho expression was ...
Aggressively de-escalated adjuvant radiotherapy for patients with HPV-associated oropharynx squamous cell carcinoma produced local tumor control rates comparable to those of historical controls, according to results of a single-arm phase 2 study published in Journal of Clinical Oncology.. The de-escalated treatment also was associated with decreased toxicity and slight improvement in swallowing function.. HPV-associated oropharyngeal squamous cell carcinoma represents a demographically and biologically distinct disease compared with historical head and neck squamous cell carcinomas, Daniel J. Ma, MD, radiation oncologist at Mayo Clinic in Rochester, Minnesota, and colleagues wrote. Patients are more likely to be younger and nonsmokers and have fewer medical comorbidities. Furthermore, in vitro and in vivo experiments have demonstrated that these tumors are more sensitive to radiotherapy and chemotherapy compared with historical head and neck squamous cell carcinomas.. The current standard ...
Basaloid squamous cell carcinoma (Bas-SqCC) is an uncommon histological variant of lung cancer composed of cells exhibiting cytological and tissue architectural features of both squamous cell lung carcinoma and basal cell carcinoma. Lung cancer is a large and exceptionally heterogeneous family of malignancies. Over 50 different histological variants of lung cancer are explicitly recognized within the fourth (2004) revision of the World Health Organization Classification of Lung Tumours (WHO-2004). Many of these entities are quite rare, have only been recently described, and remain poorly understood. Basaloid forms of lung carcinoma were first described in the peer-reviewed medical literature by Dr. Elisabeth Brambilla and her colleagues in 1992. In the third revision of the World Health Organization lung tumor typing and classification scheme, published in 1999, basaloid variants of both squamous cell lung carcinoma (SqCC) and large cell lung carcinoma (LCLC) were recognized as distinct ...
TY - JOUR. T1 - Assessment of circularized E7 RNA, GLUT1, and PD-L1 in anal squamous cell carcinoma. AU - Chamseddin, Bahir H.. AU - Lee, Eunice E.. AU - Kim, Jiwoong. AU - Zhan, Xiaowei. AU - Yang, Rong. AU - Murphy, Kathleen M.. AU - Lewis, Cheryl. AU - Hosler, Gregory A.. AU - Hammer, Suntrea T.. AU - Wang, Richard C.. PY - 2019/10/1. Y1 - 2019/10/1. N2 - Anal squamous cell carcinoma (ASCC) is a rare, potentially fatal malignancy primarily caused by high-risk human papillomaviruses (HPV). The prognostic implication of programmed death-ligand 1 (PD-L1) expression remains controversial, and glucose transporter 1 (GLUT1) expression has never been examined in ASCC. Covalently closed circular RNAs have recently been shown to be widespread in cancers and are proposed to be biomarkers. We discovered HPV16 expresses a circular E7 RNA (circE7) which has not been assessed as a potential biomarker. A retrospective, translational case series at UT Southwestern was conducted to analyze PD-L1, GLUT1, ...
Conditions: Anaplastic Thyroid Cancer; Insular Thyroid Cancer; Metastatic Parathyroid Cancer; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Non-small Cell Lung Cancer; Recurrent Parathyroid Cancer; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent ...
Title: 5-Fluorouracil Buccal Tablets for Locoregional Chemotherapy of Oral Squamous Cell Carcinoma: Formulation, Drug Release and Histological Effects on Reconstituted Human Oral Epithelium and Porcine Buccal Mucosa. VOLUME: 7 ISSUE: 2. Author(s):Libero Italo Giannola, Viviana De Caro, Giulia Giandalia, Maria Gabriella Siragusa, Carlo Paderni, Giuseppina Campisi and Ada Maria Florena. Affiliation:Department of Chemistry and Pharmaceutical Technologies, University of Palermo, Via Archirafi 32,90123 Palermo, Italy.. Keywords:5-Fluorouracil, Locoregional drug delivery, Porcine buccal mucosa, Reconstituted human oral epithelium, Oral squamous cell carcinoma, Buccal tablets. Abstract: 5-Fluorouracil (5-FU) is currently used for treatment of oral squamous cell carcinoma (OSCC). 5-FU is given by i.v. although the systemic administration is associated with severe toxic effects and no topical formulations of 5-FU for buccal drug delivery have been reported. In this study we would report the development ...
TY - JOUR. T1 - Cutaneous squamous cell carcinoma metastasis to the parotid region lymph nodes. AU - Myers, Larry L. AU - Ahn, Chul. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Objective: To determine the effect on survival of periauricular region cutaneous squamous cell carcinomas (cSCC) metastasizing to parotid region and cervical lymph nodes. Methods: From May 1995 to October 2013, consecutive patients with cSCC undergoing parotidectomy/neck dissection ≥ 18 years without distant metastasis were included. Demographic, clinical, and pathologic data were analyzed. Uni- and multivariate analyses of disease-specific survival and overall survival were performed. Statistical significance was set at P , 0.05. Results: We evaluated 137 patients. Most patients were Caucasian males with an average age of 71.6 years. The median follow-up time was 29.4 months. Thirty-six percent of patients had pathological evidence of cervical metastasis (N+). Seven percent had metastasis to level I, 21.9% to level II, 14.6% to ...
Laryngeal and hypopharyngeal squamous cell carcinomas (LHSCCs) are common head and neck cancers with a high propensity for lymph node (LN) and lung metastasis. Here, we report that LHSCCs express high levels of functional CXCR4 receptors, native for chemokine stromal cell-derived factor-1 (SDF-1/CXCL12). Primary tumor immunohistochemistry from LHSCC patients has revealed significant expression of CXCR4 and CXCL12. Greater expression of CXCR4 but not that of CXCL12 is correlated with LN and distant metastasis. Reverse transcription-polymerase chain reaction and western blots have demonstrated that CXCR4 messenger RNA (mRNA) and protein were expressed in LHSCC cell lines as well, but failed to detect CXCL12 mRNA expression. CXCL12 treatment enhanced extracellular signal-regulated kinase (ERK) pathway activation and the motility/invasiveness of LHSCC cell lines, which were blocked by treatment with a CXCR4 antagonist (AMD3100) and a specific MEK inhibitor (U0126). Results show that the mRNA and ...
Tongue squamous cell carcinoma (TSCC) is one of the most common types of oral squamous cell carcinomas (OSCC). TSCC is highly invasive and
Our aim was to document the health-related quality of life (QoL) of patients with squamous cell carcinoma (SCC) of the oral cavity who were treated with chemoradiotherapy, and to compare it with that of patients treated with conventional surgery with or without adjuvant treatment. All patients who presented with SCC of the oral cavity treated with chemoradiotherapy alone at the Royal Brisbane & Womens Hospital between 2000 and 2011 and who were alive without disease were included. Health-related QoL was assessed by the University of Washington QoL questionnaire version 4, and the European Organisation for the Research and Treatment of Cancer (EORTC) QoL questionnaires C30 and HN35. The questionnaires were sent to all survivors. Those who responded to chemoradiotherapy were matched with patients who were treated by conventional surgery with or without adjuvant treatment by age, sex, subsite of tumour, and TNM stage. Sixteen patients completed the questionnaires (8 in each group). There was no ...
The aims of this study were to evaluate whether HPV infection has a prognostic role in patients with esophageal squamous cell carcinoma who underwent oncological treatment and also to compare the heat shock proteins (Hsp) 90, 27 and 16.2 and growth hormone-releasing hormone receptor (GHRH-R) expression patterns of the pre-treatment tumor biopsies with the HPV status and with the oncological response. Pre-treatment tumor biopsies of 74 patients with locally advanced esophageal squamous cell carcinoma were processed retrospectively. The presence of HPV was detected by chromogenic in situ hybridization. Hsp and GHRH-R expressions were determined using immunohistochemistry. Following neoadjuvant or definitive radiochemotherapy, the patients were restaged according to the Response Evaluation Criteria in Solid Tumors. The correlation between the HPV status, response to treatment and Hsp and GHRH-R expressions were evaluated. Fourteen (19%) patients were HPV-positive. These patients were more likely to respond
The aims of this study were to evaluate whether HPV infection has a prognostic role in patients with esophageal squamous cell carcinoma who underwent oncological treatment and also to compare the heat shock proteins (Hsp) 90, 27 and 16.2 and growth hormone-releasing hormone receptor (GHRH-R) expression patterns of the pre-treatment tumor biopsies with the HPV status and with the oncological response. Pre-treatment tumor biopsies of 74 patients with locally advanced esophageal squamous cell carcinoma were processed retrospectively. The presence of HPV was detected by chromogenic in situ hybridization. Hsp and GHRH-R expressions were determined using immunohistochemistry. Following neoadjuvant or definitive radiochemotherapy, the patients were restaged according to the Response Evaluation Criteria in Solid Tumors. The correlation between the HPV status, response to treatment and Hsp and GHRH-R expressions were evaluated. Fourteen (19%) patients were HPV-positive. These patients were more likely to respond
Telomerase is a ribonucleoprotein enzyme that maintains telomere length. Telomerase activity is primarily attributed to the expression of telomerase reverse transcriptase (TERT). It has been reported that introduction of an intact human chromosome 3 into the human oral squamous cell carcinoma cell line HSC3 suppresses the tumorigenicity of these cells. However, the mechanisms that regulate tumorigenicity have not been elucidated. To determine whether this reduction in tumorigenicity was...
TY - JOUR. T1 - PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma. AU - Kozaki, Ken Ichi. AU - Imoto, Issei. AU - Pimkhaokham, Atiphan. AU - Hasegawa, Shogo. AU - Tsuda, Hitoshi. AU - Omura, Ken. AU - Inazawa, Johji. PY - 2006/12. Y1 - 2006/12. N2 - Phosphatidylinositol 3-kinases (PI3K) are a group of heterodimeric lipid kinases that regulate many cellular processes. Gene amplification and somatic mutations mainly within the helical (exon 9) and kinase (exon 20) domains of PIK3CA, which encode the 110-kDa catalytic subunit of PI3K and are mapped to 3q26, have been reported in various human cancers. Herein, 14 human oral squamous cell carcinoma (OSCC) cell lines and 108 primary OSCC tumors were investigated for activating mutations at exons 9 and 20 as well as amplifications in PIK3CA. PIK3CA missense mutations in exons 9 and 20 were identified in 21.4% (3/14) of OSCC cell lines and 7.4% (8/108) of OSCC tumors by genomic DNA sequencing. An increase in ...
Health care professionals may find information about advanced esophageal squamous cell carcinoma (ESCC) and KEYTRUDA® (pembrolizumab).
Squamous cell carcinoma of the gallbladder is rare and constitutes only 0.5-3% of all malignancies of this organ. Most of the reported cases have had a component of adenocarcinoma. We report a 70-year-old man who presented with acute onset right upper quadrant pain. He operated on based on a presumptive diagnosis of acute cholecystitis according to clinical and ultrasonographic findings. Histopathological examination of the infiltrating mass of the gallbladder revealed well differentiated keratinized squamous cell carcinoma invading full wall thickness. Thorough evaluations revealed no other primary site for the tumor. Pure primary squamous cell carcinoma of the gallbladder is rarely reported. Clinicians and pathologists must be aware of its vague clinical presentations.
Background: Recently, associations of the human papillomavirus (HPV) with head and neck cancer have become well established. Of particular concern, the severity and pathological outcomes of squamous cell carcinomas are remarkably affected by the genotypes of HPV present in such lesions. This study was conducted to investigate the occurrence of HPV genotypes, particularly high risk 16 and 18, among oral and laryngeal squamous cell carcinomas in Jordan. Methods: During the period of May 2015 to March 2016, we evaluated a total of 108 paraffin-embedded tissue samples, histologically confirmed as SCC, of both oral and laryngeal tumors for the presence of HPV DNA. DNA was extracted using a Zymogen commercial kit. HPV genotypes were detected by nested PCR using consensus primers followed by primer-specific PCR for HPV-16 and HPV-18 genotypes. The genotypes were confirmed by DNA sequencing methods. Results: Sixteen samples were positive for HPV DNA (14.8%) with higher rates in oral tumors compared to their
Esophageal squamous cell carcinoma (ESCC) is one of the most frequently diagnosed cancers in developing countries, especially in Eastern Asia [ 1 ].
The presence of Lymph node metastasis with extranodal extension (ENE) is considered to be an important adverse prognostic factor for survival in patients with head and neck cancer. The aim of this study was to determine the prognostic significance of ENE in patients with laryngeal squamous cell carcinoma (LSCC). Three hundred and fifty-five patients with LSCC who underwent surgical resection and neck dissection were included. The status of cervical lymph node was classified into three groups: pathological negative nodal (pN-), pathological positive nodal without ENE (ENE-), and pathological positive nodal with ENE (ENE+). A total of 85 of 355 (23.9%) LSCC were pathological nodal positive, and ENE was detected in 22/355 (6.2%) patients. ENE was associated with drinking (p=0.005), T stage (p=0.000), tumor location (p=0.000), and differentiation degree (p=0.000). The number of lymph node metastasis in ENE+ group was associated with almost twice compared to ENE- group (p=0.005). The 5-year overall ...
TY - CONF. T1 - Molecular pathogenesis of human esophageal squamous cell carcinomas. AU - Tang, Cheuk On. AU - Hu, Y.C.. AU - Law, B.F.. AU - Wong, K.Y.. AU - Hu, L.. AU - Guan, X.Y.. AU - Srivastava, G.. PY - 2002. Y1 - 2002. M3 - Conference presentation (not published in journal/proceeding/book). T2 - Hong Kong International Cancer Congress. Y2 - 1 January 2002. ER - ...
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies worldwide. MicroRNA (miRNA)‑544 is an important cancer‑associated RNA that is downregulated in multiple types of cancer. However, the role of miR‑544 in ESCC progression remains unknown. In the present study, miR‑544 expression level was determined via RT‑qPCR in 30 pairs of ESCC and adjacent normal tissues and in a panel of ESCC cell lines. Cell proliferation and cell apoptosis were assessed by MTT and flow cytometry assays. Luciferase reporter assay and western blot analysis were conducted to verify E2F transcription factor 5 (E2F5), an oncogene in ESCC, as a novel target gene of miR‑544. The results illustrated that miR‑544 is frequently downregulated in ESCC tissues and cell lines. Overexpression of miR‑544 in ESCC cells resulted in decreased cell proliferation and increased cell apoptosis. Thus, E2F5 was identified as a target of miR‑544, and its expression was negatively correlated with ...
Since this squamous cell lung cancer is being considered as destructive neoplasm in lungs, additional care is paid towards incorporating the effective supportive therapy in the regular anti cancerous therapy, involving multi drug combinations. The supportive therapy may include usage of suitable corticosteroid drugs like prednisolone in a routine form and it is noteworthy to mention that in some patients, a repository form of this corticosteroid may also be used to fulfill the need of constant delivery.. Surgery is also being considered as therapy in cases of squamous cell lung cancer. But, if the spread of this is over a wide area, it becomes impossible.. The squamous cell lung cancer in many patients tends to spread to other tissues including kidney or bone. Suppose, if it spreads to bones, most of the times, mandible or skull may get affected and in such cases increased density with occurrence of periosteal new bones may be noticed.. Squamous cell lung cancer at times need confirmation from ...
Esophageal basaloid squamous cell carcinoma (EBSCC) is a rare malignant disease. Advanced EBSCC (AEBSCC) has a poorer prognosis than the more common esophageal squamous cell carcinoma, but no treatment policy has yet been established. This is the first reported case with AEBSCC treated only with radiotherapy. Thus, our long-surviving patient merits consideration. We therefore reviewed cases with the same stage of AEBSCC for further investigation. An 85-year-old man with a chief complaint of difficulty swallowing foods was diagnosed with AEBSCC, cT3N1M0, stage III, by thorough examination. The basaloid carcinoma extended from the upper thoracic esophagus to the middle thoracic esophagus based on imaging studies, endoscopy and biopsy. Morphologically, the tumor was an elevated ulcerative area. We conducted radiotherapy to relieve symptoms, as the patient and his family refused aggressive treatment. He has remained alive without recurrence for 2 years, to date, after completing radiotherapy. Basaloid
TY - JOUR. T1 - Lactate Transporter Monocarboxylate Transporter 4 Induces Bone Pain in Head and Neck Squamous Cell Carcinoma. AU - Hasegawa, Kazuaki. AU - Okui, Tatsuo. AU - Shimo, Tsuyoshi. AU - Ibaragi, Soichiro. AU - Kawai, Hotaka. AU - Ryumon, Shoji. AU - Kishimoto, Koji. AU - Okusya, Yuka. AU - Monsur Hassan, Nur Mohammad. AU - Sasaki, Akira. PY - 2018/10/25. Y1 - 2018/10/25. N2 - Head and neck squamous cell carcinoma (HNSCC) poses a significant challenge clinically, as it can invade facial bones and cause bone pain that is undertreated and poorly understood. Here we studied HNSCC bone pain (HNSCC-BP) in an intratibial mouse xenograft model that uses a human HNSCC cell line (SAS cells). These mice develop HNSCC-BP associated with an upregulation of phosphorylated ERK1/2 (pERK1/2), which is a molecular indicator of neuron excitation in the dorsal root ganglia (DRGs) of sensory nerve cell bodies. Our experiments demonstrated that the inhibition of monocarboxylate transporter 4 (MCT4) by short ...
TY - JOUR. T1 - Incidental case of metastatic squamous cell carcinoma in the posterior thoracic wall. T2 - A cadaveric finding. AU - Kumar, Naveen. AU - Aithal, Ashwini P.. AU - Bishnu, Arijit. AU - Swamy, R. Ravindra. PY - 2016. Y1 - 2016. N2 - Occurrence of secondary tumors from visceral carcinomas on the thoracic cage represent a relatively rare form of metastasis. We present in this report an extremely rare case of an incidental finding of tumor mass (squamous cell carcinoma) in the thoracic wall of an adult male cadaver. During routine dissection of thoracic cavity, we noticed this unique tumor in the posterior thoracic wall. Its gross measurements were noted and a small piece of the tumor mass was processed for histopathological examination, to confirm its nature. The H&E stained section showed presence of infiltrating tumor composed of islands of squamous cells with pleomorphic nuclei, course chromatin, scattered dyskeratotic cells and foci of keratin pearl formation, which confirmed the ...
Bupivacaine inhibits the malignant biological behavior of oral squamous cell carcinoma cells by inhibiting the activation of ERK1/2 and STAT3
Despite improvement in preoperative imaging, surgical technique, and adjuvant therapy, the prognosis of patients with tongue squamous cell carcinoma (SCC) is still unsatisfactory. The mammalian target of rapamycin (mTOR) play a key role in the regulation of tumor cell proliferation and survival. However, the significance of mTOR on the prognosis of tongue SCC remains largely undefined. In the present study, immunohistochemistry was performed to evaluate the expression of phosphorylated mTOR (p-mTOR) in 160 surgically resected tongue SCC, and correlated with survival. Univariate analysis revealed that p-mTOR overexpression (P = 0.006) was associated with inferior overall survival. In multivariate comparison, p-mTOR overexpression (P = 0.002, hazard ratio = 2.082) remained independently associated with worse overall survival. In vitro study, tongue cancer cells treated with everolimus, the specific mTOR inhibitor, or transfected with mTOR-mediated siRNAs dramatically attenuated the abilities of ...